journal
https://read.qxmd.com/read/23984080/detailed-analysis-of-diffuse-large-b-cell-lymphoma-patients-a-single-center-retrospective-study
#21
JOURNAL ARTICLE
Murat Ozbalak, M Cem Ar, Nukhet Tuzuner, Ayse Salihoglu, A Emre Eskazan, Seniz Ongoren Aydin, Zafer Baslar, Teoman Soysal, Yildiz Aydin, Anil Barak Dolgun, Onder Ergonul, Burhan Ferhanoglu
The aim of this single-center, retrospective study was to investigate the impact of rituximab, reconsider the validity of International Prognostic Index (IPI), and evaluate the prognostic role of the cell of origin (CoO) in a relatively young cohort. Three hundred twelve diffuse large B cell lymphoma patients (median age: 52) were included. Rituximab significantly improved the 3- and 5-year progression free survival (PFS) (70% versus 65% and 41% versus 36%, resp.; P < 0.001) but led only to a slight, insignificant increase in 3- and 5-year overall survival (OS) (71% versus 77...
2013: ISRN Hematology
https://read.qxmd.com/read/23936661/frequency-and-outcome-of-graft-versus-host-disease-after-stem-cell-transplantation-a-six-year-experience-from-a-tertiary-care-center-in-pakistan
#22
JOURNAL ARTICLE
Natasha Ali, Salman Naseem Adil, Mohammad Usman Shaikh, Nehal Masood
Objective. The objective of this study was to evaluate the frequency and outcome of graft versus host disease after stem cell transplantation for various haematological disorders in Pakistan. Materials and Methods. Pretransplant workup of the patient and donor was performed. Mobilization was done with G-CSF 300  μ g twice daily for five day. Standard GvHD prophylaxis was done with methotrexate 15 mg/m(2) on day +1 followed by 10 mg/m(2) on days +3 and +6 and cyclosporine. Grading was done according to the Glucksberg classification...
2013: ISRN Hematology
https://read.qxmd.com/read/23864957/detection-of-minimal-residual-disease-by-flow-cytometry-for-patients-with-multiple-myeloma-submitted-to-autologous-hematopoietic-stem-cell-transplantation
#23
JOURNAL ARTICLE
Suzane Dal Bó, Annelise Pezzi, Bruna Amorin, Vanessa Valim, Rosane Isabel Bittencourt, Lucia Silla
The treatment strategy in multiple myeloma (MM) is to get complete remission followed by high-dose chemotherapy and autologous Hematopoietic Stem Cell Transplantation (HSCT). Neoplastic Plasma Cells (NPCs) are CD45(-/dim), CD38(+high), CD138(+), CD19(-), and  CD56(+high) in most cases. The description of this immunophenotype is of major importance as it leads to the correct identification of minimal residual disease (MRD). Samples from 44 Patients were analyzed prospectively in this study. We analyzed if the presence of MRD at three months after HSCT was predictive of relapse or death...
2013: ISRN Hematology
https://read.qxmd.com/read/23864956/bacteriological-safety-of-blood-collected-for-transfusion-at-university-of-gondar-hospital-blood-bank-northwest-ethiopia
#24
JOURNAL ARTICLE
Hailegebriel Wondimu, Zelalem Addis, Feleke Moges, Yitayal Shiferaw
Background. Transfusion associated bacterial infection has remained more frequent with a sever risk of morbidity and mortality. This study assessed the bacteriological safety of blood collected for transfusion. Method. A cross-sectional study was conducted at University of Gondar hospital blood bank from December 2011 to June 2012. Bacterial isolation, identification, and antimicrobial susceptibility tests were done as per the standard procedure. Chi-square test and P value were used to assess associations between risk factors and the bacterial isolation rate...
2013: ISRN Hematology
https://read.qxmd.com/read/23853724/expression-level-of-il-6-secreted-by-bone-marrow-stromal-cells-in-mice-with-aplastic-anemia
#25
JOURNAL ARTICLE
Yong Feng Chen, Zhong Min Wu, Cong Xie, Shi Bai, Li Dong Zhao
Parasecretion of the hematopoietic cytokines is considered as one of the mechanisms account for bone marrow hematopoiesis disorder. In this study, the level of IL-6 secreted by bone marrow stromal cells from a mouse model of aplastic anemia was analyzed. The aplastic anemia mouse model was established with cyclophosphamide in combination with chloramphenicol and (60)Co γ radiation. The impairment of bone marrow hematopoiesis induced by irradiation and chemotherapeutic drugs was subsequently characterized by peripheral blood cell count, pathomorphological changes, and apoptosis rate...
2013: ISRN Hematology
https://read.qxmd.com/read/23691341/hematological-and-genetic-predictors-of-daytime-hemoglobin-saturation-in-tanzanian-children-with-and-without-sickle-cell-anemia
#26
JOURNAL ARTICLE
Sharon E Cox, Julie Makani, Charles R Newton, Andrew M Prentice, Fenella J Kirkham
Low hemoglobin oxygen saturation (SpO2) is common in Sickle Cell Anemia (SCA) and associated with complications including stroke, although determinants remain unknown. We investigated potential hematological, genetic, and nutritional predictors of daytime SpO2 in Tanzanian children with SCA and compared them with non-SCA controls. Steady-state resting pulse oximetry, full blood count, transferrin saturation, and clinical chemistry were measured. Median daytime SpO2 was 97% (IQ range 94-99%) in SCA (N = 458), lower (P < 0...
2013: ISRN Hematology
https://read.qxmd.com/read/23606980/assessment-of-hepatic-and-pancreatic-iron-overload-in-pediatric-beta-thalassemic-major-patients-by-t2-weighted-gradient-echo-magnetic-resonance-imaging
#27
JOURNAL ARTICLE
Doaa Mohammed Youssef, Faten Fawzy Mohammad, Ayman Ahmed Fathy, Maha Aly Abdelbasset
Background. MRI has emerged for the noninvasive assessment of iron overload in various tissues. The aim of this paper is to evaluate hepatic and pancreatic iron overload by T2(∗) weighted gradient echo MRI in young beta-thalassemia major patients and to correlate it with glucose disturbance and postsplenectomy status. Subjects and Methods. 50 thalassemic patients, in addition to 15 healthy controls. All patients underwent clinical assessment and laboratory investigations. Out of 50 thalassemic patients, 37 patients were splenectomized...
2013: ISRN Hematology
https://read.qxmd.com/read/23577263/hemoglobin-a2-lowered-by-iron-deficiency-and-%C3%AE-thalassemia-should-screening-recommendation-for-%C3%AE-thalassemia-change
#28
JOURNAL ARTICLE
Srdjan Denic, Mukesh M Agarwal, Bayan Al Dabbagh, Awad El Essa, Mohamed Takala, Saad Showqi, Javed Yassin
Screening for β -thalassemia trait (BTT) relies on measuring hemoglobin (Hb) A2. Since multiple factors can affect HbA2 levels, the screening can become unreliable. In 1356 healthy Arabs enrolled into a federally funded premarital BTT screening program, the effects of iron deficiency (ID), α (+)-thalassemia trait, gender, smoking, and tribalism on HbA2 were studied. The complete blood count and hemoglobin fractions were determined on the entire cohort; serum ferritin (<15  μ g/L) in 391 subjects was used to determine ID...
2013: ISRN Hematology
https://read.qxmd.com/read/23431463/micrornas-and-glucocorticoid-induced-apoptosis-in-lymphoid-malignancies
#29
JOURNAL ARTICLE
Ronit Vogt Sionov
The initial response of lymphoid malignancies to glucocorticoids (GCs) is a critical parameter predicting successful treatment. Although being known as a strong inducer of apoptosis in lymphoid cells for almost a century, the signaling pathways regulating the susceptibility of the cells to GCs are only partly revealed. There is still a need to develop clinical tests that can predict the outcome of GC therapy. In this paper, I discuss important parameters modulating the pro-apoptotic effects of GCs, with a specific emphasis on the microRNA world comprised of small players with big impacts...
2013: ISRN Hematology
https://read.qxmd.com/read/23401787/cd47-a-cell-surface-glycoprotein-which-regulates-multiple-functions-of-hematopoietic-cells-in-health-and-disease
#30
JOURNAL ARTICLE
Per-Arne Oldenborg
Interactions between cells and their surroundings are important for proper function and homeostasis in a multicellular organism. These interactions can either be established between the cells and molecules in their extracellular milieu, but also involve interactions between cells. In all these situations, proteins in the plasma membranes are critically involved to relay information obtained from the exterior of the cell. The cell surface glycoprotein CD47 (integrin-associated protein (IAP)) was first identified as an important regulator of integrin function, but later also was shown to function in ways that do not necessarily involve integrins...
2013: ISRN Hematology
https://read.qxmd.com/read/23316379/transfusion-practices-in-the-management-of-sickle-cell-disease-a-survey-of-florida-hematologists-oncologists
#31
JOURNAL ARTICLE
Levette N Dunbar, Larae Coleman Brown, Donna R Rivera, Abraham G Hartzema, Richard Lottenberg
The purpose of this study was to characterize transfusion practices in the management of sickle cell disease and to identify factors attributing to differences in prescribing practices among Florida hematologists/oncologists. A cross-sectional study was performed in 2005-2006 utilizing a mail survey. The survey instrument addressed practice characteristics, sickle cell patient populations, transfusion settings, indications and techniques, red blood cell phenotype specifications/modifications, use of practice guidelines, and educational resource utilization...
2012: ISRN Hematology
https://read.qxmd.com/read/23316378/comparative-effects-of-three-iron-chelation-therapies-on-the-quality-of-life-of-greek-patients-with-homozygous-transfusion-dependent-beta-thalassemia
#32
JOURNAL ARTICLE
Vasilis Goulas, Alexandra Kourakli-Symeonidis, Charalambos Camoutsis
This prospective study assessed the quality of life of patients with homozygous transfusion-dependent beta-thalassemia in Greece receiving three different iron chelation treatments. Patients enrolled were receiving one of the following chelation therapies: deferoxamine (n = 21), deferasirox (n = 75), or deferoxamine in combination with deferiprone (n = 39). The three groups were compared in terms of their quality of life, satisfaction and adherence to treatment, control of their health, and self-esteem through the completion of five questionnaires...
2012: ISRN Hematology
https://read.qxmd.com/read/23209921/implications-of-weight-and-body-mass-index-for-plasma-donation-and-health
#33
JOURNAL ARTICLE
Genna A Jerrard, Jing Liu, Rosemary C Case, Mahnaz Motevalli, Stephen G Bolton, Karen E King, John Beigel, J Brooks Jackson
This study determined the percentage of potential plasma donors who could donate plasma in the 3 allowable plasma volume limit categories as specified by the Food and Drug Administration (FDA), as well as the association of the body mass index (BMI) of these individuals with age, blood pressure, oral temperature, and pulse. Of 315 plasma donors analyzed, 107 (34.0%) weighed between 110 and 149 lbs (50.0-67.7 kg), 89 (28.2%) weighed between 150 and174 lbs (68.2-79.1 kg), and 119 (37.8%) weighed >175 lbs (79...
2012: ISRN Hematology
https://read.qxmd.com/read/23209920/rhc-phenotyping-adsorption-elution-test-and-ssp-pcr-the-combined-test-for-d-elute-phenotype-screening-in-thai-rhd-negative-blood-donors
#34
JOURNAL ARTICLE
Songsak Srijinda, Chamaiporn Suwanasophon, Unchalee Visawapoka, Malinee Pongsavee
The Rhesus (Rh) blood group is the most polymorphic human blood group and it is clinically significant in transfusion medicine. Especially, D antigen is the most important and highly immunogenic antigen. Due to anti-D, it is the cause of the hemolytic disease of the newborn and transfusion reaction. About 0.1%-0.5% of Asian people are RhD-negative, whereas in the Thai population, the RhD-negative blood type only occurs in 0.3%. Approximately 10%-30% of RhD-negative in Eastern Asian people actually were D-elute (DEL) phenotype, the very weak D antigen that cannot be detected by indirect antiglobulin test (IAT)...
2012: ISRN Hematology
https://read.qxmd.com/read/23150832/evaluation-of-x-chromosome-inactivation-patterns-in-patients-with-acute-myeloid-leukemia-during-remission
#35
JOURNAL ARTICLE
Yousef Mortazavi, Saeid Kaviani, Fatemeh Mirzamohammadi, Kamran Alimoghaddam, Ali Akbar Pourfathollah, Oveis Salehi
The aim of this study was to evaluate the patterns of X-chromosome inactivation during the remission in acute myeloid leukemia (AML) at the RNA level. Two hundred normal females and 45 female patients with AML entered the study. The frequency of heterozygosity was 48.5% (119/245) for P55, 40% (93/245) for IDS, and only 28.9% (71/245) for G6PD. Some individuals were heterozygous for more than one gene polymorphism. Overall, one hundred normal individuals proved showed to be heterozygous for at least one of the above polymorphisms...
2012: ISRN Hematology
https://read.qxmd.com/read/23119174/evaluation-of-transfusion-pyrexia-a-review-of-differential-diagnosis-and-management
#36
JOURNAL ARTICLE
Oladimeji P Arewa
Background/purpose. Transfusion pyrexia (fever) is an important clinical sign/symptom occurring either as an isolated event or as part of a constellation of signs and symptoms in relation to blood transfusion. It is an important cause of morbidity and may be an important sign of life-threatening complications of blood transfusion. Pyrexia is often a reason for the discontinuation of a blood transfusion episode, and adequate evaluation remains a challenge for clinicians. The decision to stop a blood transfusion episode on account of fever is often a difficult one...
2012: ISRN Hematology
https://read.qxmd.com/read/23056956/the-effects-of-continuous-blood-purification-for-sirs-mods-patients-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#37
JOURNAL ARTICLE
Tian Hongliang, Zeng Rong, Wang Xiaojing, Sun Rao, Li Lun, Tian Jinhui, Cao Nong, Yang Kehu
Background. Continuous veno-venous hemofiltration (CVVH) has aroused great concern in recent years because its effect on clearing inflammatory mediators and its mechanism of clinical effects in the treatment of critical illness has also become a research direction. Objective. To evaluate the efficacy of continuous blood purification for systemic inflammatory response syndrome (SIRS)/multiple organ dysfunction syndrome (MODS) patients. Methods. A systematic review of the literature was undertaken to assess randomized controlled trials on CVVH...
2012: ISRN Hematology
https://read.qxmd.com/read/23008779/need-for-nucleic-acid-testing-in-countries-with-high-prevalence-of-transfusion-transmitted-infections
#38
JOURNAL ARTICLE
Rohit Jain, Pankaj Aggarwal, Gajendra Nath Gupta
Introduction. In India, family/replacement donors still provide more than 45% of the collected blood. With increasing voluntary blood donation and the still-prevalent infectious diseases in donors, we need to augment transfusion-transmitted infections (TTIs) testing before use. Our study was aimed to know the seroprevalence of TTIs among the donors of Rajasthan and the need for newer technologies like nucleic acid testing (NAT). Materials and Methods. Enhanced chemiluminescence immunoassay (ECi) was used for detection of HBsAg, anti-HIV, and anti-HCV in donor serum...
2012: ISRN Hematology
https://read.qxmd.com/read/22928115/the-platelet-function-analyzer-pfa-100-as-a-screening-tool-in-neurosurgery
#39
JOURNAL ARTICLE
Ralf Karger, Karoline Reuter, Jochen Rohlfs, Christopher Nimsky, Ulrich Sure, Volker Kretschmer
We investigated whether the inclusion of the PFA-100 in the preoperative screening of neurosurgical patients might reduce perioperative bleeding complications. Patients with intracranial space-occupying lesions who were scheduled for neurosurgery underwent routine preoperative PFA-100 testing. In case of an abnormal PFA test, patients received prophylactic treatment with desmopressin. 93 consecutive patients were compared to 102 consecutive patients with comparable characteristics operated before introduction of the PFA-100 testing...
2012: ISRN Hematology
https://read.qxmd.com/read/22919508/intermittent-iron-folate-supplementation-impact-on-hematinic-status-and-growth-of-school-girls
#40
JOURNAL ARTICLE
Aditi Sen, Shubhada Kanani
UNLABELLED: In view of high iron needs for adolescent growth, this paper studied the impact of daily vs. intermittent (once and twice weekly) iron folic acid (IFA) supplementation on hemoglobin levels and pubertal growth among primary school girls in early adolescence (9-13 years) of Vadodara, India. Methods. Hemoglobin (Hb), height and weight of the girls were assessed using standard methods. In three experimental schools (ES) IFA tablets in a dose of 100 mg Fe + 0.5 mg folic acid was given either daily, once weekly or twice weekly for one year...
2012: ISRN Hematology
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