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Multiple Sclerosis International

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https://www.readbyqxmd.com/read/27563466/evasep-a-noninterventional-study-describing-the-perception-of-neurologists-patients-and-caregivers-on-caregivers-role-in-the-support-of-patients-suffering-from-multiple-sclerosis-treated-with-subcutaneous-interferon-beta-1a
#1
Cécile Donzé, Bruno Lenne, Anne-Sophie Jean Deleglise, Christian Kempf, Yasmine Bellili, Patrick Hautecoeur
Background. The perception of the role of caregivers for people with multiple sclerosis (MS) is important but poorly studied, particularly in patients with low levels of disability. Objectives. To describe the perceptions of the role of caregivers from the perspective of the caregiver, the patient, and neurologists. Methods. This observational study was conducted in France on patients with relapsing remitting MS treated with subcutaneous (SC) interferon-β-1a (IFN-β-1a) for more than 24 months. Results. Caregiver, patients, and neurologists all considered providing moral support and fighting against the disease as the most important role of the care provider...
2016: Multiple Sclerosis International
https://www.readbyqxmd.com/read/27529034/retracted-consensus-guidelines-for-csf-and-blood-biobanking-for-cns-biomarker-studies
#2
Multiple Sclerosis International
[This retracts the article DOI: 10.1155/2011/246412.].
2016: Multiple Sclerosis International
https://www.readbyqxmd.com/read/27504201/healthy-aging-from-the-perspectives-of-683-older-people-with-multiple-sclerosis
#3
Elizabeth M Wallack, Hailey D Wiseman, Michelle Ploughman
Purpose. The aim of this study was to determine what factors most greatly contributed to healthy aging with multiple sclerosis (MS) from the perspective of a large sample of older people with MS. Design and Methods. Participants (n = 683; >55 years of age with symptoms >20 years) provided answers to an open-ended question regarding healthy aging and were categorized into three groups, 55-64 (young), 65-74 (middle), and 75 and over (oldest old). Sociodemographic actors were compared using ANOVA. Two independent raters used the framework method of analyzing qualitative data...
2016: Multiple Sclerosis International
https://www.readbyqxmd.com/read/27382489/the-incidence-of-euphoria-in-multiple-sclerosis-artefact-of-measure
#4
Amy Duncan, Susan Malcolm-Smith, Ozayr Ameen, Mark Solms
Background. A subgroup of MS patients present with "euphoria." Classical authors describe this symptom as the predominant mood state of these patients, while contemporary authors regard it as rare. Objective. This study aimed to address these discrepancies and investigate the contributions made by varying operational definitions and measurement instruments. Methods. One hundred MS patients and 100 matched controls completed the classical interview of Cottrell and Wilson and the modern Neuropsychiatric Inventory in a once-off interview...
2016: Multiple Sclerosis International
https://www.readbyqxmd.com/read/27200190/the-efficacy-of-functional-electrical-stimulation-of-the-abdominal-muscles-in-the-treatment-of-chronic-constipation-in-patients-with-multiple-sclerosis-a-pilot-study
#5
Christine Singleton, Abdel Magid Bakheit, Carla Peace
Chronic constipation in patients with multiple sclerosis (MS) is common and the current methods of treatment are ineffective in some patients. Anecdotal observations suggest that functional electrical stimulation (FES) of the abdominal muscles may be effective in the management of constipation in these patients. Patients and Methods. In this exploratory investigation we studied the effects of FES on the whole gut transit time (WGTT) and the colonic transit time (CTT). In addition, we evaluated the treatment effect on the patients' constipation-related quality of life and on the use of laxatives and the use of manual bowel evacuation...
2016: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26966579/management-of-multiple-sclerosis-in-the-breastfeeding-mother
#6
REVIEW
Saneea Almas, Jesse Vance, Teresa Baker, Thomas Hale
Multiple Sclerosis (MS) is an autoimmune neurological disease characterized by inflammation of the brain and spinal cord. Relapsing-Remitting MS is characterized by acute attacks followed by remission. Treatment is aimed at halting these attacks; therapy may last for months to years. Because MS disproportionately affects females and commonly begins during the childbearing years, clinicians treat pregnant or nursing MS patients. The intent of this review is to perform an in-depth analysis into the safety of drugs used in breastfeeding women with MS...
2016: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26966578/lack-of-association-between-pulse-steroid-therapy-and-bone-mineral-density-in-patients-with-multiple-sclerosis
#7
Serap Zengin Karahan, Cavit Boz, Sevgi Kilic, Nuray Can Usta, Mehmet Ozmenoglu, Vildan Altunayoglu Cakmak, Sibel Gazioglu
Multiple sclerosis (MS) has been associated with reduced bone mineral density (BMD). The purpose of this study was to determine the possible factors affecting BMD in patients with MS. We included consecutive 155 patients with MS and 90 age- and sex-matched control subjects. Patients with MS exhibited significantly lower T-scores and Z-scores in the femoral neck and trochanter compared to the controls. Ninety-four (61%) patients had reduced bone mass in either the lumbar spine or the femoral neck; of these, 64 (41...
2016: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26843986/stride-time-variability-and-fall-risk-in-persons-with-multiple-sclerosis
#8
Yaejin Moon, Douglas A Wajda, Robert W Motl, Jacob J Sosnoff
Gait variability is associated with falls in clinical populations. However, gait variability's link to falls in persons with Multiple Sclerosis (PwMS) is not well established. This investigation examined the relationship between stride-time variability, fall risk, and physiological fall risk factors in PwMS. 17 PwMS (62.8 ± 7.4 years) and 17 age-matched controls (62.8 ± 5.9 years) performed the 6-minute walk test. Stride-time was assessed with accelerometers attached to the participants' shanks. Stride-time variability was measured by interstride coefficient of variation (CV) of stride-time...
2015: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26839705/the-therapeutic-potential-of-the-ketogenic-diet-in-treating-progressive-multiple-sclerosis
#9
REVIEW
Mithu Storoni, Gordon T Plant
Until recently, multiple sclerosis has been viewed as an entirely inflammatory disease without acknowledgment of the significant neurodegenerative component responsible for disease progression and disability. This perspective is being challenged by observations of a dissociation between inflammation and neurodegeneration where the neurodegenerative component may play a more significant role in disease progression. In this review, we explore the relationship between mitochondrial dysfunction and neurodegeneration in multiple sclerosis...
2015: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26788369/the-communication-of-multiple-sclerosis-diagnosis-the-patients-perspective
#10
Maria Josè Messina, Gloria Dalla Costa, Mariaemma Rodegher, Lucia Moiola, Bruno Colombo, Giancarlo Comi, Vittorio Martinelli
Background. Multiple sclerosis (MS) is the leading cause of nontraumatic neurological disability in young adults in Europe and in the United States. The uncertainty regarding its evolution makes the diagnosis disclosure a difficult process. Objective. The aim of the study was to provide patients' global perspective towards MS diagnosis communication. Methods. 150 consecutive patients, recently diagnosed with CIS or MS, were asked to complete a 17-item questionnaire assessing factors influencing their satisfaction with the information provided...
2015: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26682069/comparing-three-dual-task-methods-and-the-relationship-to-physical-and-cognitive-impairment-in-people-with-multiple-sclerosis-and-controls
#11
Megan C Kirkland, Elizabeth M Wallack, Samantha N Rancourt, Michelle Ploughman
Dual-tasking (DT) is a measure to detect impairments in people with multiple sclerosis (MS). We compared three DT methods to determine whether cognitive (Montreal Cognitive Assessment (MoCA)) or physical disability (Expanded Disease Severity Scale; EDSS) was related to DT performance. We recruited MS participants with low disability (<3 EDSS, n = 13) and high disability (≥3 EDSS, n = 9) and matched controls (n = 13). Participants walked at self-selected (SS) speed on an instrumented walkway (Protokinetics, Havertown, USA), followed by DT walks in randomized order: DT ABC (reciting every second letter of the alphabet), DT 7 (serially subtracting 7's from 100), and DT 3 (counting upwards, leaving out multiples and numbers that include 3)...
2015: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26634156/adipsin-is-associated-with-multiple-sclerosis-a-follow-up-study-of-adipokines
#12
Renuka Natarajan, Sanna Hagman, Mari Hämälainen, Tiina Leppänen, Prasun Dastidar, Eeva Moilanen, Irina Elovaara
Background and Objective. The role of adipokines in regulation of immune responses has been recognized, but very little is known about their impact on multiple sclerosis (MS). In this study, we analysed whether the major adipokines are differentially expressed in plasma of patients with different MS subtypes and clinically isolated syndrome (CIS) and explored their association with major disease characteristics. Methods. The levels of adiponectin, adipsin, leptin, and resistin in the plasma of 80 patients with different subtypes of MS and CIS were followed up annually over the two years...
2015: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26483978/neuroimaging-of-natalizumab-complications-in-multiple-sclerosis-pml-and-other-associated-entities
#13
REVIEW
Justin M Honce, Lidia Nagae, Eric Nyberg
Natalizumab (Tysabri) is a monoclonal antibody (α4 integrin antagonist) approved for treatment of multiple sclerosis, both for patients who fail therapy with other disease modifying agents and for patients with aggressive disease. Natalizumab is highly effective, resulting in significant decreases in rates of both relapse and disability accumulation, as well as marked decrease in MRI evidence of disease activity. As such, utilization of natalizumab is increasing, and the presentation of its associated complications is increasing accordingly...
2015: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26266049/fingolimod-treatment-in-relapsing-remitting-multiple-sclerosis-patients-a-prospective-observational-multicenter-postmarketing-study
#14
Rocco Totaro, Caterina Di Carmine, Gianfranco Costantino, Roberta Fantozzi, Paolo Bellantonio, Aurora Fuiani, Ciro Mundi, Stefano Ruggieri, Carmine Marini, Antonio Carolei
Objective. The aim of this prospective observational multicenter postmarketing study was to evaluate fingolimod efficacy in a real world clinical setting. Methods. One hundred forty-two subjects with relapsing-remitting multiple sclerosis (RRMS) were enrolled in three multiple sclerosis centers throughout Central and Southern Italy between January 2011 and September 2013. After enrollment, regular visits and EDSS assessment were scheduled every 3 months, and MRI scan was obtained every 12 months. Patients were followed up from 1 to 33 months (mean 14...
2015: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26240760/prevalence-of-depression-and-anxiety-among-patients-with-multiple-sclerosis-attending-the-ms-clinic-at-sheikh-khalifa-medical-city-uae-cross-sectional-study
#15
Taoufik Alsaadi, Khadija El Hammasi, Tarek M Shahrour, Mustafa Shakra, Lamya Turkawi, Abdulla Mudhafar, Lina Diab, Mufeed Raoof
Depression and anxiety are reported to be prevalent in patients with MS, with prevalence rates ranging from 20% to 50%. Unfortunately, the rates, patterns, and risk factors are not well studied in our Middle East region, and, to our knowledge, not at all in UAE. Using standardized screening tools, we observed that 17% and 20% of 80 patients seen in MS clinic had scores consistent with major depression and anxiety disorders, respectively, at a rate that was not statistically different when compared to age and sex matched controls...
2015: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26236506/edss-change-relates-to-physical-hrqol-while-relapse-occurrence-relates-to-overall-hrqol-in-patients-with-multiple-sclerosis-receiving-subcutaneous-interferon-%C3%AE-1a
#16
Barbara G Vickrey, Liesly Lee, Fraser Moore, Patrick Moriarty
Objective. To compare patterns of associations of changes in mental and physical health dimensions of health-related quality of life (HRQoL) over time with relapse occurrence and changes in Expanded Disability Status Scale (EDSS) scores in patients with relapsing multiple sclerosis (RMS). Methods. This 24-month, phase IV, observational study enrolled 334 patients with RMS who received interferon β-1a 44 μg or 22 μg subcutaneously three times weekly. At each 6-month visit, patients completed the Multiple Sclerosis Quality of Life-54 (MSQOL-54) and site investigators assessed EDSS and recorded relapse occurrence...
2015: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26221541/antiepileptic-and-antidepressive-polypharmacy-in-patients-with-multiple-sclerosis
#17
Georg Anton Giæver Beiske, Trygve Holmøy, Antonie Giæver Beiske, Svein I Johannessen, Cecilie Johannessen Landmark
Objective. Patients with multiple sclerosis (MS) are often suffering from neuropathic pain. Antiepileptic drugs (AEDs) and tricyclic antidepressants (TCAs) are commonly used and are susceptible to be involved in drug interactions. The aim of this retrospective study was to investigate the prevalence of use of antiepileptic and antidepressive drugs in MS patients and to discuss the theoretical potential for interactions. Methods. Review of the medical records from all patients treated at a dedicated MS rehabilitation centre in Norway between 2009 and 2012...
2015: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26090229/development-of-activity-related-muscle-fatigue-during-robot-mediated-upper-limb-rehabilitation-training-in-persons-with-multiple-sclerosis-a-pilot-trial
#18
Johanna Renny Octavia, Peter Feys, Karin Coninx
Robot-assisted rehabilitation facilitates high-intensity training of the impaired upper limb in neurological rehabilitation. It has been clinically observed that persons with Multiple Sclerosis (MS) have difficulties in sustaining the training intensity during a session due to the development of activity-related muscle fatigue. An experimental observational pilot study was conducted to examine whether or not the muscle fatigue develops in MS patients during one session of robot-assisted training within a virtual learning environment...
2015: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26090228/applying-an-open-source-segmentation-algorithm-to-different-oct-devices-in-multiple-sclerosis-patients-and-healthy-controls-implications-for-clinical-trials
#19
Pavan Bhargava, Andrew Lang, Omar Al-Louzi, Aaron Carass, Jerry Prince, Peter A Calabresi, Shiv Saidha
Background. The lack of segmentation algorithms operative across optical coherence tomography (OCT) platforms hinders utility of retinal layer measures in MS trials. Objective. To determine cross-sectional and longitudinal agreement of retinal layer thicknesses derived from an open-source, fully-automated, segmentation algorithm, applied to two spectral-domain OCT devices. Methods. Cirrus HD-OCT and Spectralis OCT macular scans from 68 MS patients and 22 healthy controls were segmented. A longitudinal cohort comprising 51 subjects (mean follow-up: 1...
2015: Multiple Sclerosis International
https://www.readbyqxmd.com/read/26075095/the-lived-experience-of-multiple-sclerosis-relapse-how-adults-with-multiple-sclerosis-processed-their-relapse-experience-and-evaluated-their-need-for-postrelapse-care
#20
Miho Asano, Karli Hawken, Merrill Turpin, Abby Eitzen, Marcia Finlayson
Background. Multiple sclerosis (MS) relapses can take a toll on individuals' health and quality of life. Given such consequences of relapses, postrelapse care beyond pharmacological approaches may play an important role in recovery. Nevertheless, how individuals with MS process their relapse experience and manage the consequences is still uncertain. Purpose. We conducted a qualitative study to understand relapse experiences and postrelapse care need from perspectives of adults with MS and identify relapse management patterns...
2015: Multiple Sclerosis International
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