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Nutrition & Diabetes

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https://www.readbyqxmd.com/read/29695715/real-life-achievement-of-lipid-lowering-treatment-targets-in-the-diabetes-and-lifestyle-cohort-twente-systemic-assessment-of-pharmacological-and-nutritional-factors
#1
Christina M Gant, S Heleen Binnenmars, Manon Harmelink, Sabita S Soedamah-Muthu, Stephan J L Bakker, Gerjan Navis, Gozewijn D Laverman
BACKGROUND/OBJECTIVES: Lowering low-density lipoprotein cholesterol (LDLc) in type 2 diabetes mellitus is of paramount importance in preventing cardiovascular disease. However, treatment targets for LDLc are often not reached. We studied the prevalence of LDLc target achievement in a real-life population of type 2 diabetes mellitus patients in secondary care, and investigated whether in those not on target, there is room for intensifying pharmacological and lifestyle management according to current treatment guidelines...
April 25, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29695712/adherence-to-a-mediterranean-diet-and-long-term-changes-in-weight-and-waist-circumference-in-the-epic-italy-cohort
#2
Claudia Agnoli, Sabina Sieri, Fulvio Ricceri, Maria Teresa Giraudo, Giovanna Masala, Melania Assedi, Salvatore Panico, Amalia Mattiello, Rosario Tumino, Maria Concetta Giurdanella, Vittorio Krogh
Excessive calorie intake and physical inactivity are considered key determinants of the rapid worldwide increase in obesity prevalence, however the relationship between diet and weight gain is complex. We investigated associations between adherence to a Mediterranean diet and long-term changes in weight and waist circumference in volunteers recruited to the Italian section of the prospective European Prospective Investigation into Cancer and Nutrition (EPIC). We investigated 32,119 cohort members who provided anthropometric measures at recruitment and updated information on recall a mean of 12 years later...
April 25, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29695710/maternal-obesity-during-lactation-may-protect-offspring-from-high-fat-diet-induced-metabolic-dysfunction
#3
Jenifer Monks, David J Orlicky, Adrianne L Stefanski, Andrew E Libby, Elise S Bales, Michael C Rudolph, Ginger C Johnson, Vanessa D Sherk, Matthew R Jackman, Kayla Williamson, Nichole E Carlson, Paul S MacLean, James L McManaman
BACKGROUND/OBJECTIVES: The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother's dietary choices and health can affect both the early wellbeing and lifelong disease-risk of the offspring. SUBJECTS/METHODS: To determine if changes in the mother's diet and adiposity have long-term effects on the baby's metabolism, independently from a prenatal insult, we utilized a mouse model of diet-induced-obesity and cross-fostering...
April 25, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29695709/longitudinal-association-between-egg-consumption-and-the-risk-of-cardiovascular-disease-interaction-with-type-2-diabetes-mellitus
#4
Jiyoung Jang, Min-Jeong Shin, Oh Yoen Kim, Kyong Park
BACKGROUND/OBJECTIVES: It remains unclear if high egg consumption has beneficial or adverse effects on cardiometabolic health. The present study prospectively evaluated the longitudinal association between egg-consumption levels and incident cardiovascular disease (CVD) among Korean adults. SUBJECTS/METHODS: We conducted a prospective cohort study of 9248 Korean adults aged 40-69 years without CVD or cancer at the baseline from the Korean Genome and Epidemiology Study, Ansung-Ansan cohort, South Korea...
April 25, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29695708/angiopoietin-like-protein-3-and-4-in-obesity-type-2-diabetes-mellitus-and-malnutrition-the-effect-of-weight-reduction-and-realimentation
#5
Anna Cinkajzlová, Miloš Mráz, Zdeňka Lacinová, Jana Kloučková, Petra Kaválková, Helena Kratochvílová, Pavel Trachta, Jarmila Křížová, Denisa Haluzíková, Jan Škrha, Hana Papežová, Martin Haluzík
BACKGROUND: Angiopoietin-like proteins (ANGPTLs) 3 and 4 are circulating factors that participate in the regulation of lipid and glucose metabolism. SUBJECTS AND METHODS: We measured serum ANGPTL3 and 4 levels in 23 patients with obesity, 40 patients with obesity and type 2 diabetes mellitus (T2DM), 22 patients with anorexia nervosa (AN), 15 subjects undergoing 72-h fasting, and 12 patients with short bowel syndrome (SBS), and their changes after very-low-calorie diet (VLCD), bariatric surgery, partial realimentation, acute fasting, and parenteral nutrition in order to assess their possible role in metabolic regulations...
April 25, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29695707/high-orange-juice-consumption-with-or-in-between-three-meals-a-day-differently-affects-energy-balance-in-healthy-subjects
#6
Franziska A Hägele, Franziska Büsing, Alessa Nas, Julian Aschoff, Lena Gnädinger, Ralf Schweiggert, Reinhold Carle, Anja Bosy-Westphal
Sugar-containing beverages like orange juice can be a risk factor for obesity and type 2 diabetes although the underlying mechanisms are less clear. We aimed to investigate if intake of orange juice with or in-between meals differently affects energy balance or metabolic risk. Twenty-six healthy adults (24.7 ± 3.2 y; BMI 23.2 ± 3.2 kg/m2 ) participated in a 4-week cross-over intervention and consumed orange juice (20% of energy requirement) either together with 3 meals/d (WM) or in-between 3 meals/d (BM) at ad libitum energy intake...
April 25, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29695706/evaluation-of-a-12-week-lifestyle-education-intervention-with-or-without-partial-meal-replacement-in-thai-adults-with-obesity-and-metabolic-syndrome-a-randomised-trial
#7
Kusuma Chaiyasoot, Rungnapha Sarasak, Banchamaphon Pheungruang, Suwitcha Dawilai, Pornpoj Pramyothin, Adhiratha Boonyasiri, Orawan Supapueng, Friedrich C Jassil, Preyanuj Yamwong, Rachel L Batterham
BACKGROUND/OBJECTIVES: There have been no studies examining the efficacy of meal replacement (MR) on weight loss and metabolic syndrome (MS) improvement in Southeast Asians. Thus, we undertook a 12-week randomised trial to evaluate the effect of a lifestyle education intervention alone (LEI) or with partial MR (LEI + MR) in obese Thai adults with MS. SUBJECTS/METHODS: A total of 110 patients were randomised to receive either LEI or LEI + MR. Both groups received LEI to achieve weight loss...
April 25, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29695705/dietary-patterns-and-type-2-diabetes-among-ghanaian-migrants-in-europe-and-their-compatriots-in-ghana-the-rodam-study
#8
Cecilia Galbete, Mary Nicolaou, Karlijn Meeks, Kerstin Klipstein-Grobusch, Ama de-Graft Aikins, Juliet Addo, Stephen K Amoah, Liam Smeeth, Ellis Owusu-Dabo, Joachim Spranger, Charles Agyemang, Frank P Mockenhaupt, Erik Beune, Karien Stronks, Matthias B Schulze, Ina Danquah
BACKGROUND/OBJECTIVES: We aimed to study the associations of dietary patterns (DPs) with type 2 diabetes (T2D) among Ghanaian adults. SUBJECTS/METHODS: In the multi-centre, cross-sectional RODAM (Research on Obesity and Diabetes among African Migrants) study (n = 4543), three overall DPs ("mixed", "rice, pasta, meat and fish," and "roots, tubers and plantain") and two site-specific DPs per study site (rural Ghana, urban Ghana and Europe) were identified by principal component analysis...
April 25, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29695704/human-adipose-tissue-protein-analyses-using-capillary-western-blot-technology
#9
Jin Lu, Carolyn C Allred, Michael D Jensen
A capillary western blot (Wes®) technology has recently been validated for analyses of cell culture lysate proteins, but whether it is reliable for human tissue proteins is unknown. We compared traditional western blotting to the Wes® capillary western method to quantitate the relative amount of human adipose tissue CD36, the ratio of phosphorylated Erk1/2 (pErk1/2) to total Erk1/2 during insulin clamp or after niacin treatment and the fold increase in pAktS473 (Akt phosphorylation on Ser473) in response to feeding...
April 25, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29549249/geographical-variation-in-the-prevalence-of-obesity-metabolic-syndrome-and-diabetes-among-us-adults
#10
Matthew J Gurka, Stephanie L Filipp, Mark D DeBoer
Cardiovascular disease (CVD) and type 2 diabetes remain significant public health concerns. Targeting of prevention efforts by geographical location has been suggested by the Institute of Medicine to coincide with the presence of area-based risk. The metabolic syndrome (MetS) is a stronger risk factor than is obesity for the prediction of future CVD and diabetes, yet its prevalence has not previously been described geographically. Our objective is to determine geographical variation in the prevalence of obesity, MetS, and diabetes among US adults...
March 13, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29549244/effects-of-sildenafil-treatment-on-thermogenesis-and-glucose-homeostasis-in-diet-induced-obese-mice
#11
Kornelia Johann, Marlen Colleen Reis, Lisbeth Harder, Beate Herrmann, Sogol Gachkar, Jens Mittag, Rebecca Oelkrug
Stimulation of thermogenic pathways appears to be a promising approach to find new ways of tackling metabolic diseases like obesity and diabetes mellitus type 2. Thermogenic, weight reducing and insulin sensitizing effects of phosphodiesterase 5 (PDE 5) inhibitors have recently been postulated, suggesting that modulators of endogenous cGMP signaling have the therapeutic potential to treat metabolic disorders. However, most studies have been performed in vitro or in animals that were not glucose intolerant. We, thus, aimed to test the metabolic effects of the PDE 5 inhibitor sildenafil by treating diet-induced obese (DIO) mice orally for 8 days...
March 13, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29549354/the-antioxidant-potential-of-the-mediterranean-diet-in-patients-at-high-cardiovascular-risk-an-in-depth-review-of-the-predimed
#12
Hayley E Billingsley, Salvatore Carbone
Cardiovascular disease (CVD) is the leading global cause of death. Diet is known to be important in the prevention of CVD. The PREDIMED trial tested a relatively low-fat diet versus a high-fat Mediterranean diet (MedDiet) for the primary prevention of CVD. The resulting reduction of the CV composite outcome resulted in a paradigm shift in CV nutrition. Though many dietary factors likely contributed to this effect, this review focuses on the influence of the MedDiet on endogenous antioxidant systems and the effect of dietary polyphenols...
March 9, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29549246/an-audit-of-the-dietary-intake-of-australian-children-with-type-1-diabetes
#13
Heather R Gilbertson, Kristen Reed, Sarah Clark, Kate L Francis, Fergus J Cameron
To understand what children with type 1 diabetes in a representative tertiary hospital clinic are eating compared to their peers and explore dietary intake impact on HbA1c outcome. An open cross-sectional dietary audit of children and adolescents with diabetes aged 2-17 years attending the Royal Children's Hospital, Melbourne was conducted using an age-appropriate validated Food Frequency Questionnaire. Total energy, macronutrient intake and diet quality were calculated and compared to dietary advice provided and national intake data...
March 9, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29549240/vegetarian-diet-change-in-dietary-patterns-and-diabetes-risk-a-prospective-study
#14
Tina H T Chiu, Wen-Harn Pan, Ming-Nan Lin, Chin-Lon Lin
BACKGROUND/OBJECTIVES: Vegetarian diets are inversely associated with diabetes in Westerners but their impact on Asians-whose pathophysiology differ from Westerners-is unknown. We aim to investigate the association between a vegetarian diet, change in dietary patterns and diabetes risk in a Taiwanese Buddhist population. METHODS: We prospectively followed 2918 non-smoking, non-alcohol drinking Buddhists free of diabetes, cancer, and cardiovascular diseases at baseline, for a median of 5 years, with 183 incident diabetes cases confirmed...
March 9, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29549311/wheat-derived-arabinoxylan-oligosaccharides-with-bifidogenic-properties-abolishes-metabolic-disorders-induced-by-western-diet-in-mice
#15
Audrey M Neyrinck, Sophie Hiel, Caroline Bouzin, Vicenta Garcia Campayo, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne
BACKGROUND: Non-digestible carbohydrates present in cereals such as fructans and arabinoxylans represent promising prebiotic nutrients to prevent the development of obesity and related metabolic disorders. OBJECTIVE AND DESIGN:  The aim of this study was to determine the corrective effects of wheat bran-derived arabinoxylan oligosaccharides in obese mice fed a western diet (WD). WD was given for 4 weeks before wheat bran extract (WBE) supplementation (5%) for an additional 4 weeks, whereas a control group received the standard diet...
March 7, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29549245/serum-trans-fatty-acids-level-are-positively-associated-with-lower-food-security-among-american-adults
#16
Mohsen Mazidi, Hassan Vatanparast
OBJECTIVES: In the current study we aimed to assess whether the food security is associated with serum trans-fatty acids (TFAs) and dietary fat. METHODS: Analyses were restricted to participants (from the US National Health and Nutrition Examination Survey) with data available on serum and diet TFAs and food security status from 2009 to 2010. All statistical analyses (analysis of covariance and linear regression) accounted for the survey design and sample weights...
March 7, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29549243/effects-of-supplemented-isoenergetic-diets-varying-in-cereal-fiber-and-protein-content-on-the-bile-acid-metabolic-signature-and-relation-to-insulin-resistance
#17
Martin O Weickert, John G Hattersley, Ioannis Kyrou, Ayman M Arafat, Natalia Rudovich, Michael Roden, Peter Nowotny, Christian von Loeffelholz, Silke Matysik, Gerd Schmitz, Andreas F H Pfeiffer
Bile acids (BA) are potent metabolic regulators influenced by diet. We studied effects of isoenergetic increases in the dietary protein and cereal-fiber contents on circulating BA and insulin resistance (IR) in overweight and obese adults. Randomized controlled nutritional intervention (18 weeks) in 72 non-diabetic participants (overweight/obese: 29/43) with at least one further metabolic risk factor. Participants were group-matched and allocated to four isoenergetic supplemented diets: control; high cereal fiber (HCF); high-protein (HP); or moderately increased cereal fiber and protein (MIX)...
March 7, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29549241/role-of-carnitine-and-its-derivatives-in-the-development-and-management-of-type-2-diabetes
#18
REVIEW
Judit Bene, Kinga Hadzsiev, Bela Melegh
Type 2 diabetes is a highly prevalent chronic metabolic disorder characterized by hyperglycemia and associated with several complications such as retinopathy, hyperlipidemia and polyneuropathy. The dysregulated fatty acid metabolism along with tissue lipid accumulation is generally assumed to be associated in the development of insulin resistance and T2D. Moreover, several studies suggest a central role for oxidative stress in the pathogenesis of the disease. Since L-carnitine (LC) has an indispensable role in lipid metabolism via its involvement in the β-oxidation of long-chain fatty acids and it has antioxidant properties as well, carnitine supplementation may prove to be an effective tool in the management of the clinical course of T2D...
March 7, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29549238/differential-effect-of-body-mass-index-on-the-incidence-of-diabetes-and-diabetic-retinopathy-in-two-asian-populations
#19
Joel Chee Yee Chan, Miao Li Chee, Nicholas Yi Qiang Tan, Ching-Yu Cheng, Tien Yin Wong, Charumathi Sabanayagam
AIMS: To examine the association of body mass index (BMI) with the incidence of diabetes mellitus (DM) and diabetic retinopathy (DR) in Asians. METHODS: We analysed data from 4101 adults (Malay, n = 1901 and Indian, n = 2200) who participated in the baseline (2004-2009) and 6-year follow-up (2011-2015) of two independent population-based studies with similar methodology in Singapore. BMI was categorised into normal (<25 kg/m2 ), overweight (25-29.9 kg/m2 ) and obese (≥30 kg/m2 )...
March 7, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29343817/associations-between-body-mass-index-and-the-risk-of-renal-events-in-patients-with-type-2-diabetes
#20
Kamel Mohammedi, John Chalmers, William Herrington, Qiang Li, Giuseppe Mancia, Michel Marre, Neil Poulter, Anthony Rodgers, Bryan Williams, Vlado Perkovic, Josef Coresh, Mark Woodward
BACKGROUND/OBJECTIVES: We aimed to evaluate the relationship between BMI and the risk of renal disease in patients with type 2 diabetes in the Action in Diabetes and Vascular Disease: PreterAx and DiamicroN Modified-Release Controlled Evaluation (ADVANCE) study. SUBJECTS/METHODS: Participants were divided into six baseline BMI categories: <18.5 (underweight, n = 58); ≥18.5 to <25 (normal, n = 2894); ≥25 to <30 (overweight, n = 4340); ≥30 to <35 (obesity grade 1, n = 2265); ≥35 to <40 (obesity grade 2, n = 744); and ≥40 kg/m2 (obesity grade 3, n = 294); those underweight were excluded...
January 17, 2018: Nutrition & Diabetes
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