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International Journal of Surgical Oncology

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https://www.readbyqxmd.com/read/27803813/preoperative-radiation-therapy-followed-by-reexcision-may-improve-local-control-and-progression-free-survival-in-unplanned-excisions-of-soft-tissue-sarcomas-of-the-extremity-and-chest-wall
#1
Hina Saeed, David M King, Candice A Johnstone, John A Charlson, Donald A Hackbarth, John C Neilson, Manpreet Bedi
Background. The management for unplanned excision (UE) of soft tissue sarcomas (STS) has not been established. In this study, we compare outcomes of UE versus planned excision (PE) and determine an optimal treatment for UE in STS. Methods. From 2000 to 2014 a review was performed on all patients treated with localized STS. Clinical outcomes including local recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS) were evaluated using the Kaplan-Meier estimate. Univariate (UVA) and multivariate (MVA) analyses were performed to determine prognostic variables...
2016: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27747102/neoadjuvant-therapy-in-differentiated-thyroid-cancer
#2
Rajan P Dang, Daniel McFarland, Valerie H Le, Nadia Camille, Brett A Miles, Marita S Teng, Eric M Genden, Krzysztof J Misiukiewicz
Objectives. Invasion of differentiated thyroid cancer (DTC) into surrounding structures can lead to morbid procedures such as laryngectomy and tracheal resection. In these patients, there is a potential role for neoadjuvant therapy. Methods. We identified three studies involving the treatment of DTC with neoadjuvant chemotherapy: two from Slovenia and one from Japan. Results. These studies demonstrate that in selected situations, neoadjuvant chemotherapy can have a good response and allow for a more complete surgical resection, the treatment of DTC...
2016: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27190644/liposarcoma-of-the-spermatic-cord-impact-of-final-surgical-intervention-an-institutional-experience
#3
R Bachmann, J Rolinger, P Girotti, H G Kopp, K Heissner, B Amend, A Königsrainer, R Ladurner
BACKGROUND: Paratesticular liposarcomas are almost always mistakenly diagnosed as inguinal hernias subsequently followed by inadequate operation. METHODS: 14 consecutive patients with paratesticular liposarcoma were retrospectively reviewed. Preoperative management was evaluated. Disease-free and overall survival were determined. RESULTS: In 11 patients primary and in 3 patients recurrent liposarcoma of the spermatic cord were diagnosed. Regarding primary treatment in primary surgical intervention resection was radical (R0) in 7 of 14 (50%) patients, marginal (R1) in 6 (43%) patients, and incomplete with macroscopic residual tumour (R2) in 1 (7%) patient...
2016: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27110398/current-practice-of-therapeutic-mammaplasty-a-survey-of-oncoplastic-breast-surgeons-in-england
#4
Shweta Aggarwal, Sekhar Marla, Donald Nyanhongo, Sita Kotecha, Narendra Nath Basu
INTRODUCTION: Therapeutic mammaplasty (TM) is a useful technique in the armamentarium of the oncoplastic breast surgeon (OBS). There is limited guidance on patient selection, technique, coding, and management of involved margins. The practices of OBS in England remain unknown. METHODS: Questionnaires were sent to all OBS involved with the Training Interface Group. We assessed the number of TM cases performed per surgeon, criteria for patient selection, pedicle preference, contralateral symmetrisation, use of routine preoperative MRI, management of involved margins, and clinical coding...
2016: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27034826/a-structured-assessment-to-decrease-the-amount-of-inconclusive-endometrial-biopsies-in-women-with-postmenopausal-bleeding
#5
M C Breijer, N C M Visser, N van Hanegem, A A van der Wurff, B C Opmeer, H C van Doorn, B W J Mol, J M A Pijnenborg, A Timmermans
OBJECTIVE: To determine whether structured assessment of outpatient endometrial biopsies decreases the number of inconclusive samples. DESIGN: Retrospective cohort study. SETTING: Single hospital pathology laboratory. POPULATION: Endometrial biopsy samples of 66 women with postmenopausal bleeding, collected during the usual diagnostic work-up and assessed as insufficient for a reliable histological diagnosis. METHODS: Endometrial biopsy samples were requested from the pathology laboratories...
2016: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27006828/prognostic-relevance-of-the-peritoneal-surface-disease-severity-score-compared-to-the-peritoneal-cancer-index-for-colorectal-peritoneal-carcinomatosis
#6
Jia Lin Ng, Whee Sze Ong, Claramae Shulyn Chia, Grace Hwei Ching Tan, Khee-Chee Soo, Melissa Ching Ching Teo
BACKGROUND: Peritoneal Carcinomatosis Index (PCI) is a widely established scoring system that describes disease burden in isolated colorectal peritoneal carcinomatosis (CPC). Its significance may be diminished with complete cytoreduction. We explore the utility of the recently described Peritoneal Surface Disease Severity Score (PSDSS) and compare its prognostic value against PCI. METHODS: The endpoints were overall survival (OS), progression-free survival (PFS), and survival less than 18 months (18 MS)...
2016: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26989509/a-review-of-the-literature-on-extrarenal-retroperitoneal-angiomyolipoma
#7
REVIEW
Anthony Kodzo-Grey Venyo
BACKGROUND: Extrarenal retroperitoneal angiomyolipomas are rare. AIM: To review the literature. RESULTS: Angiomyolipomas, previously classified as hamartomas, are now classified as benign tumours. Thirty cases of primary retroperitoneal angiomyolipomas have been reported. Diagnosis of the disease upon is based radiological and pathological findings of triphasic features of (a) fat and (b) blood vessels and myoid tissue. Immunohistochemistry tends to be positive for HMB45, MART1, HHF35, calponin, NKI-C3, and CD117...
2016: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26955484/neoadjuvant-chemotherapy-in-locally-advanced-and-borderline-resectable-nonsquamous-sinonasal-tumors-esthesioneuroblastoma-and-sinonasal-tumor-with-neuroendocrine-differentiation
#8
Vijay M Patil, Amit Joshi, Vanita Noronha, Vibhor Sharma, Saurabh Zanwar, Sachin Dhumal, Shubhada Kane, Prathamesh Pai, Anil D'Cruz, Pankaj Chaturvedi, Atanu Bhattacharjee, Kumar Prabhash
INTRODUCTION: Sinonasal tumors are chemotherapy responsive which frequently present in advanced stages making NACT a promising option for improving resection and local control in borderline resectable and locally advanced tumours. Here we reviewed the results of 25 such cases treated with NACT. MATERIALS AND METHODS: Sinonasal tumor patients treated with NACT were selected for this analysis. These patients received NACT with platinum and etoposide for 2 cycles. Patients who responded and were amenable for gross total resection underwent surgical resection and adjuvant CTRT...
2016: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26425367/influence-of-individual-surgeon-volume-on-oncological-outcome-of-colorectal-cancer-surgery
#9
Marleen Buurma, Hidde M Kroon, Marlies S Reimers, Peter A Neijenhuis
BACKGROUND: Surgery performed by a high-volume surgeon improves short-term outcomes. However, not much is known about long-term effects. Therefore we performed the current study to evaluate the impact of high-volume colorectal surgeons on survival. METHODS: We conducted a retrospective analysis of our prospectively collected colorectal cancer database between 2004 and 2011. Patients were divided into two groups: operated on by a high-volume surgeon (>25 cases/year) or by a low-volume surgeon (<25 cases/year)...
2015: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26167298/a-single-centre-analysis-of-clinical-characteristics-and-treatment-of-endocrine-pancreatic-tumours
#10
M T Adil, R Nagaraja, V Varma, N Mehta, V Kumaran, S Nundy
Background. Endocrine Pancreatic Tumours (PENs) are rare and can be nonfunctioning or functioning. They carry a good prognosis overall though high grade lesions show a relatively shorter survival. The aim of the current study is to describe a single centre analysis of the clinical characteristics and surgical treatment of PENs. Patients and Methods. This is a cohort analysis of 40 patients of PENs who underwent surgery at Sir Ganga Ram Hospital, New Delhi, India, from 1995 to 2013. Patient particulars, clinical features, surgical interventions, postoperative outcome, and followup were done and reviewed...
2015: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26075090/gastrectomy-and-d2-lymphadenectomy-for-gastric-cancer-a-meta-analysis-comparing-the-harmonic-scalpel-to-conventional-techniques
#11
REVIEW
Hang Cheng, Chia-Wen Hsiao, Jeffrey W Clymer, Michael L Schwiers, Bryanna N Tibensky, Leena Patel, Nicole C Ferko, Edward Chekan
The ultrasonic Harmonic scalpel has demonstrated clinical and surgical benefits in dissection and coagulation. To evaluate its use in gastrectomy, we conducted a systematic review and meta-analysis of randomized controlled trials comparing the Harmonic scalpel to conventional techniques in gastrectomy for patients with gastric cancer. International databases were searched without language restrictions for comparisons in open or laparoscopic gastrectomy and lymphadenectomy. The meta-analysis used a random-effects model for all outcomes; continuous variables were analyzed for mean differences and dichotomous variables were analyzed for risk ratios...
2015: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25977821/now-later-of-never-multicenter-randomized-controlled-trial-call-is-surgery-necessary-after-atypical-breast-core-biopsy-results-in-mammographic-screening-settings
#12
RANDOMIZED CONTROLLED TRIAL
Nikita Makretsov
Breast cancer mammographic screening leads to detection of premalignant and preinvasive lesions with an increasing frequency. Nevertheless, current epidemiologic evidence indicates that the screening reduces breast cancer specific mortality, but not overall mortality in breast cancer patients. The evidence is lacking whether aggressive eradication of DCIS (preinvasive form of breast carcinoma) by surgery and radiation is of survival benefit, as long-term breast cancer specific mortality in a cohort of patients with DCIS is already in a single digit percent range...
2015: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25878899/mucus-containing-cystic-lesions-mucocele-of-the-appendix-the-unresolved-issues
#13
Mohammad Ezzedien Rabie, Mubarak Al Shraim, Mohammad Saad Al Skaini, Saad Alqahtani, Ismail El Hakeem, Abdulla Saad Al Qahtani, Tarek Malatani, Abduelah Hummadi
BACKGROUND: Mucocele of the appendix is a rare condition, the pathological classification and management strategy of which have not been standardized yet. AIM: To report on our management of appendiceal mucocele, highlighting the pitfalls and possible means for avoiding them. MATERIALS AND METHODS: Our registries were reviewed to retrieve cases of appendiceal mucocele, encountered in the period from July 2008 to May 2013. RESULTS: We had 9 cases, three males and sex females, with a median age of 62 years...
2015: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25785195/implementation-of-a-robotic-surgical-program-in-gynaecological-oncology-and-comparison-with-prior-laparoscopic-series
#14
COMPARATIVE STUDY
Natalia Povolotskaya, Robert Woolas, Dirk Brinkmann
BACKGROUND: Robotic surgery in gynaecological oncology is a rapidly developing field as it offers several technical advantages over conventional laparoscopy. An audit was performed on the outcome of robotic surgery during our learning curve and compared with recent well-established laparoscopic procedure data. METHOD: Following acquisition of the da Vinci Surgical System (Intuitive Surgical, Inc., Sunnyvale, California, USA), we prospectively analysed all cases performed over the first six months by one experienced gynaecologist who had been appropriately trained and mentored...
2015: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25785194/peritoneal-carcinomatosis-intraoperative-parameters-in-open-coliseum-versus-closed-abdomen-hipec
#15
E Halkia, A Tsochrinis, D T Vassiliadou, A Pavlakou, A Vaxevanidou, A Datsis, E Efstathiou, J Spiliotis
BACKGROUND: Peritoneal carcinomatosis (PC) is associated with a poor prognosis. Cytoreductive surgery (CRS) and HIPEC play an important role in well-selected patients with PC. The aim of the study is to present the differences in the intraoperative parameters in patients who received HIPEC in two different manners, open versus closed abdomen. PATIENTS AND METHODS: The population includes 105 patients with peritoneal carcinomatosis from colorectal, gastric, and ovarian cancer, sarcoma, mesothelioma, and pseudomyxoma peritonei...
2015: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25741445/pelvic-exenteration-experience-from-a-rural-cancer-center-in-developing-world
#16
Sampada B Dessai, Satheesan Balasubramanian, Vijay M Patil, Santam Chakraborty, Atanu Bhattacharjee, Syam Vikram
BACKGROUND: Pelvic exenteration (PE) is a morbid procedure. Ours is a rural based cancer center limited trained surgical oncology staff. Hence, this audit was planned to evaluate morbidity and outcomes of all patients undergoing PE at our center. METHODS: This is a IRB approved retrospective audit of all patients who underwent PE at our center from January 2010 to August 2013. The toxicity grades were retrospectively assigned according to the CTCAE version 4.02 criteria...
2015: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25692038/contralateral-risk-reducing-mastectomy-review-of-risk-factors-and-risk-reducing-strategies
#17
REVIEW
N N Basu, L Barr, G L Ross, D G Evans
Rates of contralateral risk-reducing mastectomy have increased substantially over the last decade. Surgical oncologists are often in the frontline, dealing with requests for this procedure. This paper reviews the current evidence base regarding contralateral breast cancer, assesses the various risk-reducing strategies, and evaluates the cost-effectiveness of contralateral risk-reducing mastectomy.
2015: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25692037/minimising-unnecessary-mastectomies-in-a-predominantly-chinese-community
#18
Mona P Tan, Nadya Y Sitoh, Yih Y Sitoh
BACKGROUND: Recent data shows that the use of breast conservation treatment (BCT) for breast cancer may result in superior outcomes when compared with mastectomy. However, reported rates of BCT in predominantly Chinese populations are significantly lower than those reported in Western countries. Low BCT rates may now be a concern as they may translate into suboptimal outcomes. A study was undertaken to evaluate BCT rates in a cohort of predominantly Chinese women. METHODS: All patients who underwent surgery on the breast at the authors' healthcare facility between October 2008 and December 2011 were included in the study and outcomes of treatment were evaluated...
2015: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25685552/clear-cell-adenocarcinoma-of-the-urethra-review-of-the-literature
#19
REVIEW
Anthony Kodzo-Grey Venyo
BACKGROUND: Clear cell adenocarcinoma of the urethra (CCAU) is extremely rare and a number of clinicians may be unfamiliar with its diagnosis and biological behaviour. AIMS: To review the literature on CCAU. METHODS: Various internet databases were used. RESULTS/LITERATURE REVIEW: (i) CCAU occurs in adults and in women in the great majority of cases. (ii) It has a particular association with urethral diverticulum, which has been present in 56% of the patients; is indistinguishable from clear cell adenocarcinoma of the female genital tract but is not associated with endometriosis; and probably does not arise by malignant transformation of nephrogenic adenoma...
2015: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25685551/evaluating-the-feasibility-of-performing-window-of-opportunity-trials-in-breast-cancer
#20
Angel Arnaout, Susan Robertson, Iryna Kuchuk, Demetrios Simos, Gregory R Pond, Christina L Addison, Mehrzad Namazi, Mark Clemons
BACKGROUND: The waiting period to surgery represents a valuable "window of opportunity" to evaluate novel therapeutic strategies. Interventional studies performed during this period require significant multidisciplinary collaboration to overcome logistical hurdles. We undertook a one-year prospective window of opportunity study to assess feasibility. METHODS: Eligible newly diagnosed postmenopausal, estrogen receptor positive breast cancer patients awaiting primary surgery received anastrozole daily until surgery...
2015: International Journal of Surgical Oncology
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