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Journal of Caffeine Research

Zachary A Vesoulis, Christopher McPherson, Jeffrey J Neil, Amit M Mathur, Terrie E Inder
Background: Although evidence suggests that methylxanthines may lower the seizure threshold, the effect of high-dose caffeine on seizure burden in preterm infants is not known. This study reports a secondary post hoc analysis of a randomized controlled trial of early high-dose caffeine citrate therapy in preterm infants, evaluating the effect of caffeine on the seizure burden using amplitude-integrated electroencephalography (aEEG). Methods: Seventy-four preterm infants (≤30 weeks gestation) were randomized to receive high-dose (n = 37, 80 mg/kg over 36 hours) or standard-dose (n = 37, 30 mg/kg over 36 hours) caffeine citrate over the first 36 hours followed by standard maintenance therapy...
September 1, 2016: Journal of Caffeine Research
Caitlin K Kelly, J Roxanne Prichard
Objective: The present study investigates risk behaviors, sleep habits, and mental health factors associated with caffeinated beverage use in young adults. Materials and Methods: Students from a midsize private university (n = 159) completed a 15-minute anonymous questionnaire, including questions on risk behaviors, sleep habits, alcohol, and caffeine consumption. We compared behaviors between the top ∼15% ("high end") of energy drink users (≥3/month) and coffee users (≥16/month) to those with less frequent or no caffeine consumption...
June 1, 2016: Journal of Caffeine Research
Naomi R Marmorstein
Background: Little is known about possible links between energy drink use and psychopathology among youth. This study examined cross-sectional and longitudinal associations between energy drink consumption and psychopathology among early adolescents. In addition, associations between psychopathology and coffee consumption were examined to assess whether findings were specific to energy drinks or also applied to another commonly used caffeinated beverage. Methods: One hundred forty-four youth who participated in the Camden Youth Development Study (72 males; mean age 11...
June 1, 2016: Journal of Caffeine Research
Gareth Richards, Andrew P Smith
Background: Concerns have been expressed regarding the potential for caffeinated energy drinks to negatively affect mental health, and particularly so in young consumers at whom they are often targeted. The products are frequently marketed with declarations of increasing mental and physical energy, providing a short-term boost to mood and performance. Although a certain amount of evidence has accumulated to substantiate some of these claims, the chronic effects of energy drinks on mental health also need to be addressed...
June 1, 2016: Journal of Caffeine Research
Steven E Meredith, Mary M Sweeney, Patrick S Johnson, Matthew W Johnson, Roland R Griffiths
Background: Energy drink use is associated with increased risk behavior among adolescents and college students. This study examined this relationship in a nationwide sample of young adults and also examined relations between energy drink use and delay discounting. Methods: Participants were 874 U.S. adults 18-28 years of age with past 30-day consumption of caffeine and alcohol. Participants completed an online survey of energy drink use, drug use, sexual activity, alcohol misuse (alcohol use disorders identification test [AUDIT]), sensation seeking (four-item Brief Sensation Seeking Scale [BSSS-4]), and delay discounting of monetary rewards and condom use...
March 1, 2016: Journal of Caffeine Research
Sakina H Sojar, Lydia A Shrier, Rosemary E Ziemnik, Lon Sherritt, Allegra L Spalding, Sharon Levy
Purpose: Pediatric caffeine use has become increasingly prevalent. The American Academy of Pediatrics discourages caffeine use by children and adolescents due to its adverse impact on sleep and blood pressure. The objective of this study was to measure prevalence of physical and emotional symptoms related to caffeine consumption among adolescents receiving primary care. Methods: A convenience sample of patients (N = 179; 73% female) aged 12-17 presenting for routine primary care completed the Composite International Diagnostic Interview Substance Abuse Module questionnaire, which included questions regarding use of caffeine...
December 1, 2015: Journal of Caffeine Research
Abigail E Kennedy, L Michelle Grimes, Rachel S Labaton, Jeffrey F Hine, William J Warzak
Introduction: We present a review of the methodological aspects of caffeine research within animal tests of escape and avoidance behavior in the presence of aversive stimuli. Method: We highlight species, methods of caffeine administration, dosage, dependent measures, and research designs commonly used in this research. Results: Typical subjects were rodents and zebrafish, with species-specific vehicles of caffeine administration and dependent measures. Behavioral tests for escape and avoidance as a function of caffeine consumption were conceptually similar across species, although the arrangement of measures was necessarily adapted to the physiological contingencies of the different species...
December 1, 2015: Journal of Caffeine Research
Jennifer L Temple, Amanda M Ziegler, Catherine Martin, Harriet de Wit
Background: Our previous work has shown that there are sex differences in subjective responses to acute caffeine administration in adolescents. The purpose of this study was to determine if these sex differences are dependent on pubertal development. Materials and Methods: We examined subjective responses before and after administration of 0, 1, and 2 mg/kg of caffeine in pre- and postpubertal boys and girls (n = 112). In addition, we examined differences in subjective responses to acute caffeine in both the luteal and follicular phases of the menstrual cycle in postpubertal girls...
December 1, 2015: Journal of Caffeine Research
Andrew V Kuczmarski, Nancy Cotugna, Marc A Mason, Michele K Evans, Alan B Zonderman
Background: Recent research has linked caffeine consumption with a lower risk for depression and cognitive decline. However, no studies have examined the relationship in an African American compared to a white, socioeconomically diverse representative urban sample. Methods: Data from a cross-sectional study were used to determine the associations of caffeine use with depressive symptomatology and cognition in a sample of 1,724 participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study...
March 1, 2015: Journal of Caffeine Research
Naomi Yamada-Fowler, Peter Söderkvist
Studies of gene-environment interactions may help us to understand the disease mechanisms of common and complex diseases such as Parkinson's disease (PD). Sporadic PD, the common form of PD, is thought to be a multifactorial disorder caused by combinations of multiple genetic factors and environmental or life-style exposures. Since one of the most extensively studied life-style factors in PD is coffee/caffeine intake, here, the studies of genetic polymorphisms with life-style interactions of sporadic PD are reviewed, focusing on coffee/caffeine intake...
March 1, 2015: Journal of Caffeine Research
Inmaculada Iglesias, Jose Luis Albasanz, Mairena Martín
Background: Caffeine is the most widely consumed psychoactive substance in the world, even during pregnancy. Its stimulatory effects are mainly due to antagonism of adenosine actions by blocking adenosine A1 and A2A receptors. Previous studies have shown that caffeine can cross the placenta and therefore modulate these receptors not only in the fetal brain but also in the heart. Methods: In the present work, the effect of caffeine chronically consumed during pregnancy on A1 and A2A receptors in Wistar rat heart, from both mothers and their fetuses, were studied using radioligand binding, Western-blotting, and adenylyl cyclase activity assays, as well as reverse transcription polymerase chain reaction...
December 1, 2014: Journal of Caffeine Research
Patricia A Broderick, Lauren B Malave
Background: Sex differences in cocaine abuse are well established. Females have a higher sensitivity and thus higher vulnerability to cocaine abuse compared to males. There are many studies showing that sensitivity to cocaine reward varies during the estrus cycle. Methods: Vaginal smears were examined through a DIFF staining kit and viewed through a microscope to determine the estrus cycle stage. Smears were taken immediately before and after cocaine and/or caffeine injections. Furthermore, we suggest a new tool to analyze the estrus cycle by using electrical resistance of the vaginal mucosa...
December 1, 2014: Journal of Caffeine Research
Hayley R Treloar, Thomas M Piasecki, Danielle E McCarthy, Timothy B Baker
Caffeine consumption and cigarette smoking tend to occur within the same individuals and at the same time. One potential explanation for this co-use is that caffeine consumption increases subjective smoking reinforcement. Electronic diaries were used to collect momentary reports of smoking, caffeine consumption, temptation/urge to smoke, and subjective smoking reinforcement in 74 prequit smokers. Momentary reports of caffeine consumption and smoking were associated, replicating previous findings. These results remained significant when contextual factors (time of day, weekday/weekend, presence of others, presence of others smoking, location, and past hour alcohol consumption) were covaried...
September 1, 2014: Journal of Caffeine Research
Robert J Barry, Frances M De Blasio, Adele E Cave
Background: Research has reliably demonstrated that caffeine produces a general increase in physiological arousal in humans, but we previously failed to obtain the expected arousal-based changes in manually quantified event-related potential (ERP) components in response to the stimuli in a simple Go/NoGo task. Methods: A single oral dose of caffeine (250 mg) was used in a randomized double-blind placebo-controlled repeated-measures cross-over study. Adult participants (N=24) abstained from caffeine for 4 hours before each of two sessions, approximately 1 week apart...
September 1, 2014: Journal of Caffeine Research
Cecile A Marczinski, Amy L Stamates, Julianne Ossege, Sarah F Maloney, Mark E Bardgett, Clifford J Brown
Background: Energy drinks and energy shots are popular consumer beverages that are advertised to increase feelings of alertness. Typically, these products include high levels of caffeine, a mild psychostimulant drug. The scientific evidence demonstrating the specific benefits of energy products to users in terms of subjective state and objective performance is surprisingly lacking. Moreover, there are rising health concerns associated with the use of these products. Therefore, the purpose of this study was to investigate the acute effects of a popular energy shot (5-Hour Energy(®)) on subjective and objective measures that were assessed hourly for 6 hours following consumption...
June 1, 2014: Journal of Caffeine Research
Lauren B Malave, Patricia A Broderick
Background: It is well known that the reinforcing properties of cocaine addiction are caused by the sharp increase of dopamine (DA) in the reward areas of the brain. However, other mechanisms have been speculated to contribute to the increase. Adenosine is one system that is associated with the sleep-wake cycle and is most important in regulating neuronal activity. Thus, more and more evidence is pointing to its involvement in regulating DA release. The current study set out to examine the role of adenosine in cocaine-induced DA release...
June 1, 2014: Journal of Caffeine Research
Anjalene Whittier, Sixto Sanchez, Benjamín Castañeda, Elena Sanchez, Bizu Gelaye, David Yanez, Michelle A Williams
Objectives: The aims of this study were to evaluate patterns of circadian preferences and daytime sleepiness, and to examine the extent to which the consumption of stimulant beverages is associated with daytime sleepiness and evening chronotype among Peruvian college-age students. Methods: A total of 2,581 undergraduate students completed a self-administered comprehensive questionnaire that gathered information about sleep habits, sociodemographic and lifestyle characteristics, and the use of caffeinated beverages...
March 1, 2014: Journal of Caffeine Research
Emma K Keenan, Brian Tiplady, Caroline M Priestley, Peter J Rogers
Background: Disruptive effects of caffeine on sleep have previously been reported, although measures of next-day mood and performance have rarely been included. The present study aims to evaluate the effects of caffeine on sleep and associated next-day effects in a naturalistic field setting. Methods: Nineteen participants (daily caffeine intake 0-141 mg), assessed as good sleepers, took part in a randomized, placebo-controlled, double-blind, 2-week crossover study to assess the effects of bedtime caffeine use (250 mg) on sleep and next-day cognitive performance and mood, which were assessed on a mobile phone in the morning and afternoon...
March 1, 2014: Journal of Caffeine Research
Ryan D White, Brett B Holdaway, Joshua D Moody, Yingzi Chang
Background: Inflammation is considered to be a major initiator to angioplasty-induced vascular restenosis. Proinflammatory cytokines stimulate vascular smooth muscle cell (VSMC) migration and proliferation leading to neointimal hyperplasia. It has been reported that chronic caffeine use suppresses the production of proinflammatory cytokine TNF-α (tumor necrosis factor Alpha) and alters adenosine receptor expression in human neutrophils, indicating that caffeine may attenuate vascular injury-induced inflammation and subsequent neointimal hyperplasia...
December 1, 2013: Journal of Caffeine Research
Ari O Moré, Francisco J Cidral-Filho, Leidiane Mazzardo-Martins, Daniel F Martins, Francisney P Nascimento, Shin Min Li, Adair R S Santos
BACKGROUND: The use of acupuncture in the treatment of pain conditions has been extensively investigated. However, the influence of dietary ingredients on acupuncture-induced analgesia (AA) remains unexplored. Recently, the role of adenosine receptors in AA has been shown, and caffeine, one of the world's most commonly consumed dietary ingredients, is an antagonist of these receptors. In this study, the postincisional pain model was used to investigate caffeine's influence on AA. METHOD: Mice submitted to plantar incision surgery were treated with acupuncture needling after administration of acute or chronic caffeine...
September 2013: Journal of Caffeine Research
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