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Dementia and Geriatric Cognitive Disorders Extra

journal
https://www.readbyqxmd.com/read/28868068/assessing-capacity-in-the-elderly-comparing-the-moca-with-a-novel-computerized-battery-of-executive-function
#1
Megan Brenkel, Kenneth Shulman, Elias Hazan, Nathan Herrmann, Adrian M Owen
BACKGROUND/AIMS: Clinicians are increasingly being asked to provide their opinion on the decision-making capacity of older adults, while validated and widely available tools are lacking. We sought to identify an online cognitive screening tool for assessing mental capacity through the measurement of executive function. METHODS: A mixed elderly sample of 45 individuals, aged 65 years and older, were screened with the Montreal Cognitive Assessment (MoCA) and the modified Cambridge Brain Sciences Battery...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28868067/cerebrospinal-fluid-apolipoprotein-e-levels-in-delirium
#2
Gideon A Caplan, JIan Tai, Fazrul Mohd Hanizan, Catherine L McVeigh, Mark A Hill, Anne Poljak
BACKGROUND/AIMS: Delirium and the apolipoprotein E ε4 allele are risk factors for late-onset Alzheimer disease (LOAD), but the connection is unclear. We looked for an association. METHODS: Inpatients with delirium (n = 18) were compared with LOAD outpatients (n = 19), assaying blood and cerebrospinal fluid (CSF) using multiplex ELISA. RESULTS: The patients with delirium had a higher Confusion Assessment Method (CAM) score (5.6 ± 1.2 vs. 0...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28868066/distinguishing-depressive-pseudodementia-from-alzheimer-disease-a-comparative-study-of-hippocampal-volumetry-and-cognitive-tests
#3
Sevki Sahin, Tugba Okluoglu Önal, Nilgun Cinar, Meral Bozdemir, Rahmi Çubuk, Sibel Karsidag
BACKGROUND AND AIM: Depressive pseudodementia (DPD) is a condition which may develop secondary to depression. The aim of this study was to contribute to the differential diagnosis between Alzheimer disease (AD) and DPD by comparing the neurocognitive tests and hippocampal volume. MATERIALS AND METHODS: Patients who met criteria of AD/DPD were enrolled in the study. All patients were assessed using the Wechsler Memory Scale (WMS), clock-drawing test, Stroop test, Benton Facial Recognition Test (BFRT), Boston Naming Test, Mini-Mental State Examination (MMSE), and Geriatric Depression Scale (GDS)...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28690635/the-development-of-the-dementia-screening-battery-100-instrument-presentation-reliability-and-construct-validity
#4
Tarek Bellaj, Sonia Ben Jemaa, Maher Khelifa, Mona Ben Djebara, Riadh Gouider, Didier Le Gall
BACKGROUND/AIM: The screening of dementia in non-Westerners has so far relied on translations and adaptations of reputed instruments. Other efforts focused on developing culturally appropriate tests or tests in touch with new developments in the field. This study presents the rationale behind the construction of a new dementia screening test: the Dementia Screening Battery-100 (DSB-100). METHODS: The DSB-100 was administered to 46 demented individuals and 159 healthy matched controls...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28690634/preventive-effect-of-rifampicin-on-alzheimer-disease-needs-at-least-450-mg-daily-for-1-year-an-fdg-pet-follow-up-study
#5
Tomomichi Iizuka, Kozo Morimoto, Yuka Sasaki, Masashi Kameyama, Atsuyuki Kurashima, Kazumasa Hayasaka, Hideo Ogata, Hajime Goto
BACKGROUND: Rifampicin was reported to inhibit amyloid-β oligomerization and tau hyperphosphorylation in mouse models and could serve as a promising available medicine for the prevention of Alzheimer disease (AD). To examine whether rifampicin has such preventive effects in humans, we retrospectively reviewed (18)F-FDG-PET findings of elderly patients with mycobacterium infection treated with rifampicin. METHODS: Forty nondemented elderly patients treated with rifampicin for mycobacterium infections who showed AD-type hypometabolism were enrolled...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28690633/how-do-community-dwelling-persons-with-alzheimer-disease-fall-falls-in-the-finalex-study
#6
Niko M Perttila, Hannareeta Öhman, Timo E Strandberg, Hannu Kautiainen, Minna Raivio, Marja-Liisa Laakkonen, Niina Savikko, Reijo S Tilvis, Kaisu H Pitkala
BACKGROUND: People with dementia are at high risk for falls. However, little is known of the features causing falls in Alzheimer disease (AD). Our aim was to investigate how participants with AD fall. METHODS: In the FINALEX (Finnish Alzheimer Disease Exercise Trial) study, participants' (n = 194) falls were followed up for 1 year by diaries kept by their spouses. RESULTS: The most common reason for falls (n = 355) was stumbling (n = 61). Of the falls, 123 led to injuries, 50 to emergency department visits, and 13 to fractures...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28690632/neuropsychological-differences-related-to-age-in-dementia-with-lewy-bodies
#7
Yasuhiro Nagahama, Tomoko Okina, Norio Suzuki
BACKGROUND/AIMS: To examine the influence of age on neuropsychological performances in dementia with Lewy bodies (DLB) and Alzheimer disease (AD) patients. METHODS: We examined memory, executive, and visuo-constructional performances in 202 DLB patients and 236 AD patients. We divided the subjects into three age groups (65-74, 75-84, and 85-95 years old), and evaluated the differences in neuropsychological performances. RESULTS: Recent memory in the DLB group was significantly better than that in the age-matched AD group when comparing the age groups 65-74 years and 75-84 years; however, memory impairment in the DLB patients in the age group 85-95 years was comparable with that in the age-matched AD patients...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28626471/early-versus-late-onset-alzheimer-disease-long-term-functional-outcomes-nursing-home-placement-and-risk-factors-for-rate-of-progression
#8
Carina Wattmo, Åsa K Wallin
BACKGROUND/AIMS: Whether age at onset influences functional deterioration in Alzheimer disease (AD) is unclear. We, therefore, investigated risk factors for progression in activities of daily living (ADL) and nursing home placement (NHP) in cholinesterase inhibitor (ChEI)-treated patients with early-onset AD (EOAD) versus late-onset AD (LOAD). METHODS: This 3-year, prospective, observational, multicenter study included 1,017 participants with mild-to-moderate AD; 143 had EOAD (onset <65 years) and 874 LOAD (onset ≥65 years)...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28626470/multi-infarct-dementia-a-historical-perspective
#9
REVIEW
Erin McKay, Scott E Counts
BACKGROUND: Multi-infarct dementia (MID), a prominent subtype of vascular dementia (VaD), has only achieved recognition in the last 4 decades. Since its original description, the characterization, etiological understanding, and therapeutic direction of MID and other VaD subtypes has progressed at an astounding rate. SUMMARY: This paper divides the landmark discoveries and emergence of new research strategies for MID into decade-defining patterns so that a condensed picture of the total history of MID and its eventual inclusion as a VaD subtype emerges...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28626469/serum-amino-acid-profiles-in-normal-subjects-and-in-patients-with-or-at-risk-of-alzheimer-dementia
#10
Gaetano Corso, Adriana Cristofano, Nadia Sapere, Giancarlo la Marca, Antonella Angiolillo, Michela Vitale, Roberto Fratangelo, Teresa Lombardi, Carola Porcile, Mariano Intrieri, Alfonso Di Costanzo
BACKGROUND/AIMS: Abnormalities in the plasma amino acid profile have been reported in Alzheimer disease (AD), but no data exist for the prodromal phase characterized by subjective memory complaint (SMC). It was our aim to understand if serum amino acid levels change along the continuum from normal to AD, and to identify possible diagnostic biomarkers. METHODS: Serum levels of 15 amino acids and 2 organic acids were determined in 4 groups of participants - 29 with probable AD, 18 with mild cognitive impairment (MCI), 24 with SMC, and 46 cognitively healthy subjects (HS) - by electrospray tandem mass spectrometry...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28626468/efficacy-and-safety-of-mlc601-in-the-treatment-of-mild-cognitive-impairment-a-pilot-randomized-double-blind-placebo-controlled-study
#11
Hossein Pakdaman, Ali Amini Harandi, Mehdi Abbasi, Hosein Delavar Kasmaei, Farzad Ashrafi, Koroush Gharagozli, Farhad Assarzadegan, Behdad Behnam, Mehran Arabahmadi
BACKGROUND AND AIM: Mild cognitive impairment (MCI) is characterized by declined cognitive function greater than that expected for a person's age. The clinical significance of this condition is its possible progression to dementia. MLC601 is a natural neuroprotective medication that has shown promising effects in Alzheimer disease. Accordingly, we conducted this randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of MLC601 in MCI patients. METHODS: Seventy-two patients with a diagnosis of MCI were recruited...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28611822/disease-progression-in-mild-dementia-due-to-alzheimer-disease-in-an-18-month-observational-study-geras-the-impact-on-costs-and-caregiver-outcomes
#12
Roy W Jones, Jeremie Lebrec, Kristin Kahle-Wrobleski, Grazia Dell'Agnello, Giuseppe Bruno, Bruno Vellas, Josep M Argimon, Richard Dodel, Josep Maria Haro, Anders Wimo, Catherine Reed
BACKGROUND/AIMS: We assessed whether cognitive and functional decline in community-dwelling patients with mild Alzheimer disease (AD) dementia were associated with increased societal costs and caregiver burden and time outcomes. METHODS: Cognitive decline was defined as a ≥3-point reduction in the Mini-Mental State Examination and functional decline as a decrease in the ability to perform one or more basic items of the Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory (ADCS-ADL) or ≥20% of instrumental ADL items...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28611821/patients-with-mild-cognitive-impairment-show-lower-visual-short-term-memory-performance-in-feature-binding-tasks
#13
Raju P Sapkota, Ian van der Linde, Nirmal Lamichhane, Tirthalal Upadhyaya, Shahina Pardhan
BACKGROUND: Early cognitive changes in people at risk of developing dementia may be detected using behavioral tests that examine the performance of typically affected brain areas, such as the hippocampi. An important cognitive function supported by the hippocampi is memory binding, in which object features are associated to create a unified percept. AIM: To compare visual short-term memory (VSTM) binding performance for object names, locations, and identities between a participant group known to be at higher risk of developing dementia (mild cognitive impairment [MCI]) and healthily aging controls...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28611820/white-matter-disruption-and-connected-speech-in-non-fluent-and-semantic-variants-of-primary-progressive-aphasia
#14
Karine Marcotte, Naida L Graham, Kathleen C Fraser, Jed A Meltzer, David F Tang-Wai, Tiffany W Chow, Morris Freedman, Carol Leonard, Sandra E Black, Elizabeth Rochon
Differential patterns of white matter disruption have recently been reported in the non-fluent (nfvPPA) and semantic (svPPA) variants of primary progressive aphasia (PPA). No single measure is sufficient to distinguish between the PPA variants, but connected speech allows for the quantification of multiple measures. The aim of the present study was to further investigate the white matter correlates associated with connected speech features in PPA. We examined the relationship between white matter metrics and connected speech deficits using an automated analysis of transcriptions of connected speech and diffusion tensor imaging in language-related tracts...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28553314/effect-of-the-sonas-programme-on-communication-in-people-with-dementia-a-randomized-controlled-trial
#15
Benedicte Sørensen Strøm, Knut Engedal, Jurate Saltyte Benth, Ellen-Karine Grov
BACKGROUND: Strategies to improve communication in people with dementia are warranted. We examined the effect of the Sonas programme on communication ability in persons with moderate to severe dementia. METHODS: A 24-week 3-armed (Sonas, reading, and control group) randomized controlled trial including 120 nursing home residents with dementia was conducted; 105 completed the follow-up assessments. The main outcome was change in communication abilities measured by the Holden Communication Scale (HCS)...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28553313/associations-between-pain-and-quality-of-life-in-severe-dementia-a-norwegian-cross-sectional-study
#16
Hanne Marie Rostad, Martine T E Puts, Milada Cvancarova Småstuen, Ellen Karine Grov, Inger Utne, Liv Halvorsrud
BACKGROUND/AIMS: Many variables influence the quality of life in older adults with dementia. We aim to quantify how the relationship between pain and quality of life in nursing home residents with severe dementia can be explained by neuropsychiatric symptoms, depressive symptoms, and activities of daily living. METHODS: This article presents cross-sectional baseline data from a cluster randomised controlled trial. RESULTS: The total and direct effects of pain on quality of life were statistically significant...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28553312/gender-differences-in-verbal-and-visuospatial-working-memory-tasks-in-patients-with-mild-cognitive-impairment-and-alzheimer-disease
#17
M Rosa Elosúa, María José Ciudad, María José Contreras
BACKGROUND/AIMS: To date, there are few studies on gender differences in patients with mild cognitive impairment (MCI) and Alzheimer disease (AD). In the present study, the existence of differences between sexes in verbal and visuospatial working memory tasks in the evolution of cognitive and pathological aging was examined. METHOD: Ninety participants took part in this study: 30 AD, 30 MCI, and 30 healthy elderly participants (50% men and 50% women). RESULTS: There were no significant differences between men and women with AD in visuospatial tasks, whereas these differences were found within the MCI group, with the average of men achieving significantly higher results than women...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28413415/effects-of-nursing-home-residency-on-diabetes-care-in-individuals-with-dementia-an-explorative-analysis-based-on-german-claims-data
#18
Larissa Schwarzkopf, Rolf Holle, Michaela Schunk
AIMS: This claims data-based study compares the intensity of diabetes care in community dwellers and nursing home residents with dementia. METHODS: Delivery of diabetes-related medical examinations (DRMEs) was compared via logistic regression in 1,604 community dwellers and 1,010 nursing home residents with dementia. The intra-individual effect of nursing home transfer was evaluated within mixed models. RESULTS: Delivery of DRMEs decreases with increasing care dependency, with more community-living individuals receiving DRMEs...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28413414/comedication-and-treatment-length-in-users-of-acetylcholinesterase-inhibitors
#19
Anne Sverdrup Efjestad, Hege Ihle-Hansen, Vidar Hjellvik, Hege Salvesen Blix
BACKGROUND/AIMS: Reduced clinical effect on cognitive decline in dementia by acetylcholinesterase inhibitors (AChEIs) may be due to concurrent use of drugs with anticholinergic properties. The aim was to analyze the incidence of AChEI use and comedication with drugs with anticholinergic properties and other potential unfavorable effects. METHODS: A prospective study applying drug use data from the Norwegian Prescription Database. Anticholinergic Drug Scale (ADS) scores were used as a measure of overall anticholinergic burden...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28413413/the-risk-of-incident-mild-cognitive-impairment-and-progression-to-dementia-considering-mild-cognitive-impairment-subtypes
#20
Tzeyu L Michaud, Dejun Su, Mohammad Siahpush, Daniel L Murman
BACKGROUND: It remains unclear how demographic and clinical characteristics are related to the risk of incident mild cognitive impairment (MCI) by its subtypes. Moreover, the contribution of the subtypes of incident MCI to the progression to dementia remains puzzling. METHODS: We used data collected by the National Alzheimer Coordinating Center. Our analysis sample included cognitively normal subjects at baseline. The associations were examined using competing-risks survival regression models and Cox proportional hazards models...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
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