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Dementia and Geriatric Cognitive Disorders Extra

Tomaž Rus, Bogdan Lorber, Maja Trošt, Srečko Dobrecovič, Nuška Čakš Jager, Mara Popović, Milica G Kramberger
Background: Creutzfeldt-Jakob disease (CJD) is a rare fatal neurodegenerative disorder presenting with rapid cognitive decline and additional signs. The clinical characteristics of an increasing number of sporadic CJD (sCJD) patients admitted to the Ljubljana University Medical Centre are presented as well as the incidence of sCJD in Slovenia in 2015 compared to previous years. Methods: We investigated patients presenting with rapidly progressive dementia and at least one additional sign...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
Fiammetta Monacelli, Alessio Signori, Matteo Prefumo, Chiara Giannotti, Alessio Nencioni, Emanuele Romairone, Stefano Scabini, Patrizio Odetti
Background/Aims: Postoperative delirium (POD) is more frequent in elderly patients undergoing major cancer surgery. The interplay between individual clinical vulnerability and a series of perioperative factors seems to play a relevant role. Surgery is the first-line treatment option for cancer, and fast-track surgery (FTS) has been documented to decrease postoperative complications. The study sought to assess, after comprehensive geriatric assessment (CGA) and frailty stratification (Rockwood 40 items index), which perioperative parameters were predictive of POD development in elderly patients undergoing FTS for colorectal cancer...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
Makiko Abe, Ken-Ichi Tabei, Masayuki Satoh, Mari Fukuda, Hironobu Daikuhara, Mariko Shiga, Hirotaka Kida, Hidekazu Tomimoto
Background/Aims: The missing fundamental phenomenon (MFP) is a universal pitch perception illusion that occurs in animals and humans. In this study, we aimed to determine whether the MFP is impaired in patients with Alzheimer's disease (AD) using an auditory pitch perception experiment. We further examined anatomical correlates of the MFP in patients with AD by measuring gray matter volume (GMV) on magnetic resonance images via voxel-based morphometric analysis. Methods: We prospectively enrolled 29 patients with AD and 20 healthy older adults...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
Peter Bruhn, Jesper Dammeyer
Background/Aims: Individuals with dual sensory loss (DSL) are more likely to experience cognitive decline with age than individuals without sensory loss. Other studies have pointed to the challenges in assessing cognitive abilities in individuals with DSL, as most existing instruments rely on use of vision and hearing. The aim of this study was to develop and evaluate a Tactile Test Battery (TTB) for cognitive assessment in individuals with DSL. Method: Twenty elderly individuals with DSL, 20 with diagnosed dementia, and 20 without dementia or DSL (controls) completed the following tactile tests developed for the present study: Spatial learning, Spatial recall, Tactile form board, Clock reading, and Naming...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
Satoshi Hayashi, Seishi Terada, Etsuko Oshima, Shuhei Sato, Kairi Kurisu, Shintaro Takenoshita, Osamu Yokota, Norihito Yamada
Objective: Among many cognitive function deficits, memory impairment is an initial and cardinal symptom in Alzheimer disease (AD). In most cases, verbal and visual memory scores correlate highly, but in some cases the deficit of verbal or visual memory is very different from that of the other memory. In this study, we examined the neural substrates of verbal and visual memory in patients with AD. Methods: One hundred eighty-eight consecutive patients with AD were recruited from outpatient units...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
Akito Tsugawa, Yusuke Ogawa, Naoto Takenoshita, Yoshitsugu Kaneko, Hirokuni Hatanaka, Eriko Jaime, Raita Fukasawa, Haruo Hanyu
Background/Aims: Diabetes-related dementia (DrD), a dementia subgroup associated with specific diabetes mellitus (DM)-related metabolic abnormalities, is clinically and pathophysiologically different from Alzheimer disease (AD) and vascular dementia. We determined whether skeletal muscle strength, quality, and mass decrease in individuals with DrD. Methods: We evaluated grip and knee extension strength, muscle mass, and gait speed in 106 patients with probable AD and without type 2 DM (AD[-DM] group), 74 patients with probable AD and with DM (AD[+DM] group), and 36 patients with DrD (DrD group)...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
(no author information available yet)
[This corrects the article DOI: 10.1159/000468923.].
September 2017: Dementia and Geriatric Cognitive Disorders Extra
Jingkai Wei, Yirui Hu, Li Zhang, Qiang Hao, Ruowei Yang, Haidong Lu, Xuan Zhang, Eeshwar K Chandrasekar
Background: To estimate a pooled association between hearing impairment and risk of mild cognitive impairment and dementia. Methods: PubMed, Embase, and Web of Science were searched for prospective cohort studies that examined the association between hearing impairment and risk of mild cognitive impairment and/or dementia. Random-effects models were fitted to estimate the summary risk ratios (RRs) and 95% confidence interval (CIs), which represents the pooled association between hearing impairment with risk of mild cognitive impairment and dementia, compared to subjects free of hearing impairment...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
Catharina Melander, Jesper Martinsson, Silje Gustafsson
Background: Understanding and interpreting the complexity of agitation in people with dementia is challenging. Objective: To explore whether a sensor measuring electrodermal activity (EDA) can improve the identification of agitation in individuals with dementia. Methods: Nine individuals with dementia wore a sensor that measured EDA. During the same time, assistant nurses annotated the observed behavior of the person with dementia. A binary logistic regression model was applied to assess the relationship between the sensor and the assistant nurses' structured observations of agitation...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
Masoome Salehi, Mohsen Reisi, Leila Ghasisin
Background: The purpose of the study was to analyze naming errors in patients with Alz-heimer's disease in comparison to healthy subjects and determine the underlying cause of naming errors in these patients. Method: In this study, we included 35 healthy elderly subjects, 23 patients with mild Alzheimer's disease, and 23 with moderate Alzheimer's disease. Forty-five images were used to determine the type of naming errors, and to identify the underlying cause of errors, matching an image with a written word was used...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
Masayuki Satoh, Keisuke Okamoto, Ken-Ichi Tabei, Hirotaka Kida, Hidekazu Tomimoto, Hideo Eda
Aims: The aims of this study were (1) to investigate the influence of physical movement on near-infrared spectroscopy (NIRS) data, (2) to establish a video-NIRS system which simultaneously records NIRS data and the subject's movement, and (3) to measure the oxygenated hemoglobin (oxy-Hb) concentration change (Δoxy-Hb) during a word fluency (WF) task. Experiment 1: In 5 healthy volunteers, we measured the oxy-Hb and deoxygenated hemoglobin (deoxy-Hb) concentrations during 11 kinds of facial, head, and extremity movements...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
Mariko Sakai, Hiroaki Kazui, Kazue Shigenobu, Kenjiro Komori, Manabu Ikeda, Takashi Nishikawa
Objective: To investigate the gustatory function in patients with semantic dementia (SD). Methods: Detection and recognition thresholds of the 4 basic tastes (sweet, salty, sour, and bitter), taste discrimination, and taste identification were evaluated in 18 patients with SD, 18 patients with Alzheimer disease (AD), and 22 healthy controls. Results: Total detection and recognition threshold values were significantly higher in the SD and AD groups than in the control group...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
Mari Kasai, Kenichi Meguro, Hiroshi Ozawa, Keiichi Kumai, Hideki Imaizumi, Hanae Minegishi, Hideki Oi, Akira Oizumi, Masahiro Yamashiro, Michimasa Matsuda, Masahiko Tanaka, Eiji Itoi
Background/Aim: The purpose of this study was to investigate the estimated prevalence of dementia and the relationship between cognitive impairment and fear of falling in patients with hip fractures. Methods: Analysis 1 included 100 patients with hip fractures. Analysis 2 included a subgroup of subjects with ≥75 years of functional independence: 46 patients with hip fractures and 46 control subjects without hip fractures, and presence or absence of dementia. We used an informant-rated questionnaire including the AD8 for screening for dementia, the Barthel Index for assessing activities of daily living, and the Short Falls Efficacy Scale-International (FES-I) for assessing fear of falling...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
Karen Roksund Hov, Nils Bolstad, Ane-Victoria Idland, Henrik Zetterberg, Kaj Blennow, Farrukh A Chaudhry, Frede Frihagen, Johan Ræder, Torgeir Bruun Wyller, Leiv Otto Watne
Objectives: This study aimed to investigate the relationship between cerebrospinal fluid (CSF) S100B astrocyte-derived protein and delirium and to perform stratified analyses according to clinical and CSF markers of dementia. Methods: We performed a prospective cohort study in a university hospital setting. The participants were patients admitted for hip fracture (n = 98) or for elective surgery (n = 50). Delirium was assessed daily perioperatively in hip fracture patients using the Confusion Assessment Method...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
Fangzhou Li, Hajime Takechi, Atsuko Kokuryu, Ryosuke Takahashi
Background: Neuropsychological tests that can track changes in cognitive functions after diagnosis of Alzheimer disease (AD) and mild cognitive impairment (MCI), including episodic memory, should be further developed. Methods: The participants of our study consisted of 22 mild AD patients and 11 MCI patients. They were followed up for 2 years. Brief cognitive screening tests were administered to the participants. Longitudinal changes in test performance were evaluated and analyzed...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
Adreesh Mukherjee, Atanu Biswas, Arijit Roy, Samar Biswas, Goutam Gangopadhyay, Shyamal Kumar Das
Aims: To evaluate the behavioural and psychological symptoms of dementia (BPSD), to determine their correlation with types and stages of dementia and patient demographics, and to assess the impact on caregiver distress. Methods: This cross-sectional study recruited consecutive dementia patients and caregivers who attended our cognitive clinic. Standard criteria were used to classify types of dementia. BPSD were assessed with the Neuropsychiatric Inventory, and its distress scale was used for caregiver distress...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
Sabrina Pickens, Aanand D Naik, Angela Catic, Mark E Kunik
Background: Although community-dwelling persons with dementia have an increased risk of hospital readmission, no systematic review has examined the contribution of dementia to readmissions. Summary: We examined articles in English, with no restrictions on publication dates, from Medline, PubMed, PsycINFO, CINAHL, and EMBASE. Keywords used were dementia , Alzheimer disease , frontotemporal lobar degeneration , elderly , frontotemporal dementia , executive function , brain atrophy , frontal lobe atrophy , cognitive impairment , readmission , readmit , rehospitalization , patient discharge , and return visit ...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
Andreas Ihle, Élvio R Gouveia, Bruna R Gouveia, Matthias Kliegel
Aims: The present study set out to evaluate the psychometric properties of the Cognitive Telephone Screening Instrument (COGTEL) in 2 different samples of older adults. Methods: We assessed COGTEL in 116 older adults, with retest after 7 days to evaluate the test-retest reliability. Moreover, we assessed COGTEL in 868 older adults to evaluate convergent validity to the Mini-Mental State Examination (MMSE). Results: Test-retest reliability of the COGTEL total score was good at 0...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
Martina Schmidhuber, Sandra Haeupler, Velislava Marinova-Schmidt, Andreas Frewer, Peter L Kolominsky-Rabas
Background: Advance directives could be an important instrument to support a person's will once he/she is not able to consent anymore - if composed competently. A survey was conducted to identify the level of knowledge concerning possibilities and limits of advance directives. Methods: The study was conducted as part of the Bavarian Dementia Survey (BayDem). Data were collected from January 2014 to December 2015 by structured face-to-face interviews. Study participants were persons with dementia and their informal caregivers (n = 74)...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
Håkon Ihle-Hansen, Thea Vigen, Trygve Berge, Gunnar Einvik, Dag Aarsland, Ole Morten Rønning, Bente Thommessen, Helge Røsjø, Arnljot Tveit, Hege Ihle-Hansen
Aims: To investigate Montreal Cognitive Assessment (MoCA) test scores in a cohort aged 63-65 years from a general population in relation to the proposed cut-off score of 26 for mild cognitive impairment (MCI) and to explore the impact of education. Methods: MoCA scores were assessed in the Akershus Cardiac Examination 1950 Study, a cross-sectional cohort study of all men and women born in 1950 living in Akershus County, Norway. The participants were aged 63-65 at the time of data collection...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
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