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Dementia and Geriatric Cognitive Disorders Extra

Karin Hesseberg, Astrid Bergland, Elisabeth Rydwik, Therese Brovold
BACKGROUND/AIMS: There is evidence of an association between cognitive function and physical fitness. The aim of this study was to compare physical fitness in patients with cognitive impairment with a group of older people recently discharged from hospital. METHODS: A cross-sectional study with 98 patients recently diagnosed with cognitive impairment and 115 patients recently discharged from hospital. Associations between the study group variable and different components in the Senior fitness test were examined, controlling for demographic factors and comorbidity...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
Marwan Sabbagh, SeolHeui Han, SangYun Kim, Hae-Ri Na, Jae-Hong Lee, Nagaendran Kandiah, Kammant Phanthumchinda, Chuthamanee Suthisisang, Vorapun Senanarong, Ming-Chyi Pai, Diatri Narilastri, Ajit M Sowani, Encarnita Ampil, Amitabh Dash
BACKGROUND: The 'Asia-Pacific Expert Panel (APEX) for donepezil 23 mg' met in November 2015 to review evidence for the recently approved high dose of donepezil and to provide recommendations to help physicians in Asia make informed clinical decisions about using donepezil 23 mg in patients with moderate-to-severe Alzheimer's disease (AD). SUMMARY: In a global phase III study (study 326) in patients with moderate-to-severe AD, donepezil 23 mg/day demonstrated significantly greater cognitive benefits versus donepezil 10 mg/day, with a between-treatment difference in mean change in the Severe Impairment Battery score of 2...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
Yoshitaka Ouchi, Mari Kasai, Kei Nakamura, Masahiro Nakatsuka, Kenichi Meguro
BACKGROUND/AIMS: We investigated quantitative/qualitative changes of instrumental activities of daily living (IADL) in people with a Clinical Dementia Rating (CDR) of 0.5. METHODS: IADLs were evaluated in older residents: CDR of 0 (healthy) and CDR 0.5 (questionable/very mild dementia). The subjects with CDR 0.5 were divided into 2 types: the very mild Alzheimer's disease (vmAD) type and the other type including very mild subcortical vascular dementia. IADLs were evaluated quantitatively using the Lawton and the original qualitative IADL scales...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Christopher Rohde, Esben Agerbo, Philip Rising Nielsen
BACKGROUND/AIMS: Prior studies have consistently found a higher risk of dementia in individuals with schizophrenia, but whether this is due to a common etiology between the disorders remains obscure. We wanted to elucidate this association by investigating whether schizophrenia in offspring increases the risk of Alzheimer's dementia. METHODS: All individuals born between 1930 and 1953 were identified through national registers and followed from their 50th birthday until the date of Alzheimer's dementia, death or end of the study...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Yoritoshi Kobayashi, Yumi Takahashi, Takashi Seki, Tomohiro Kaneta, Kenichi Amarume, Mari Kasai, Kenichi Meguro
BACKGROUND/AIMS: No previous studies have explored the relationship between physical activity (PA) and executive dysfunction. METHODS: We retrospectively evaluated the PA for 590 older participants in the Kurihara Project; 221 participants had a Clinical Dementia Rating (CDR) of 0 (healthy), 295 CDR 0.5 (very mild dementia), and 74 CDR 1+ (dementia). RESULTS: In the complicated task, whether the motor intensity was high (e.g. farming) or low (e...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Kaori Kitamura, Yumi Watanabe, Kazutoshi Nakamura, Kazuhiro Sanpei, Minako Wakasugi, Akio Yokoseki, Osamu Onodera, Takeshi Ikeuchi, Ryozo Kuwano, Takeshi Momotsu, Ichiei Narita, Naoto Endo
BACKGROUND/AIMS: Evidence on modifiable factors associated with cognitive impairment in Japanese patients is scarce. This study aimed to determine modifiable factors for cognitive impairment in a Japanese hospital-based population. METHODS: Subjects of this cross-sectional study were 1,143 patients of Sado General Hospital (Niigata, Japan) registered in the Project in Sado for Total Health (PROST) between June 2008 and September 2014. We assessed disease history, body mass index (BMI), leisure time physical activity, walking time, smoking and drinking habits, and consumption of vegetables, fruits, and green tea as predictors, with cognitive impairment defined by the Mini-Mental State Examination (score <24) as an outcome...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Lieke H H Meeter, Holger Patzke, Gordon Loewen, Elise G P Dopper, Yolande A L Pijnenburg, Rick van Minkelen, John C van Swieten
BACKGROUND: Pathogenic mutations in the granulin gene (GRN) are causative in 5-10% of patients with frontotemporal dementia (FTD), mostly leading to reduced progranulin protein (PGRN) levels. Upcoming therapeutic trials focus on enhancing PGRN levels. METHODS: Fluctuations in plasma PGRN (n = 41) and its relationship with cerebrospinal fluid (CSF, n = 32) and specific single nucleotide polymorphisms were investigated in pre- and symptomatic GRN mutation carriers and controls...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Miguel Ángel Muñoz-Ruiz, Anette Hall, Jussi Mattila, Juha Koikkalainen, Sanna-Kaisa Herukka, Minna Husso, Tuomo Hänninen, Ritva Vanninen, Yawu Liu, Merja Hallikainen, Jyrki Lötjönen, Anne M Remes, Irina Alafuzoff, Hilkka Soininen, Päivi Hartikainen
BACKGROUND: Disease State Index (DSI) and its visualization, Disease State Fingerprint (DSF), form a computer-assisted clinical decision making tool that combines patient data and compares them with cases with known outcomes. AIMS: To investigate the ability of the DSI to diagnose frontotemporal dementia (FTD) and Alzheimer's disease (AD). METHODS: The study cohort consisted of 38 patients with FTD, 57 with AD and 22 controls. Autopsy verification of FTD with TDP-43 positive pathology was available for 14 and AD pathology for 12 cases...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Fanni Haapalinna, Teemu Paajanen, Janne Penttinen, Hannu Kokki, Merja Kokki, Anne M Koivisto, Päivi Hartikainen, Eino Solje, Tuomo Hänninen, Anne Marja Remes, Sanna-Kaisa Herukka
BACKGROUND: Data on the association of memory performance with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are inconsistent. The Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery (CERAD-NB) is a commonly used validated cognitive tool; however, only few studies have examined its relationship with CSF biomarkers for AD. We studied the correlation of pathological changes in CSF biomarkers with various CERAD-NB subtests and total scores...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Cecilia Albala, Barbara Angel, Lydia Lera, Hugo Sanchez, Carlos Marquez, Patricio Fuentes
OBJECTIVE: The aim was to study the role of leptin in the development of dementia. METHODS: Follow-up of the ALEXANDROS cohorts, with baseline measurements in 2000. From 1,136 available subjects free of dementia at baseline, 667 subjects had frozen baseline blood samples for measuring leptin and soluble leptin receptor (sOB-R). The free leptin index (FLI) was calculated as the ratio of leptin to sOB-R. Dementia was defined as an MMSE score <22 and a score >5 in the Pfeffer Activities Questionnaire...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Annika Öhrfelt, Per Johansson, Anders Wallin, Ulf Andreasson, Henrik Zetterberg, Kaj Blennow, Johan Svensson
BACKGROUND: Dysfunctions of the ubiquitin proteasome system (UPS), including the highly abundant neuronal enzyme ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), and autophagy-related changes (lysosomal degradation) are implicated in several neurodegenerative disorders including Alzheimer's disease (AD). METHOD: This study evaluated cerebrospinal fluid (CSF) levels of UCH-L1, protein deglycase (DJ-1), neuron-specific enolase (NSE), and tau phosphorylated at threonine 231 (P-tau231) in two independent patient and control cohorts...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Xin Xu, Qun Lin Chan, Saima Hilal, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Boon Yeow Tan, Yanhong Dong, Christopher Li-Hsian Chen, Simon L Collinson
AIMS: To examine the diagnostic utility of the National Institute of Neurological Disorders and Stroke and the Canadian Stroke Network (NINDS-CSN) neuropsychological battery in memory clinics comparing controls with patients with no cognitive impairment (NCI), patients with cognitive impairment-no dementia (CIND) at varying severity levels (mild/moderate), and patients with dementia. METHODS: A total of 405 participants with NCI, CIND or dementia were assessed with the NINDS-CSN battery...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Chin Yee Cheong, Jane An Qi Tan, Yi-Lin Foong, Hui Mien Koh, Denise Zhen Yue Chen, Jessie Joon Chen Tan, Chong Jin Ng, Philip Yap
BACKGROUND/AIMS: The acute hospital ward can be unfamiliar and stressful for older patients with impaired cognition, rendering them prone to agitation and resistive to care. Extant literature shows that music therapy can enhance engagement and mood, thereby ameliorating agitated behaviours. This pilot study evaluates the impact of a creative music therapy (CMT) programme on mood and engagement in older patients with delirium and/or dementia (PtDD) in an acute care setting. We hypothesize that CMT improves engagement and pleasure in these patients...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Miguel F Gago, Darya Yelshyna, Estela Bicho, Hélder David Silva, Luís Rocha, Maria Lurdes Rodrigues, Nuno Sousa
BACKGROUND/AIMS: Alzheimer's disease (AD) patients have an impaired ability to quickly reweight central sensory dependence in response to unexpected body perturbations. Herein, we aim to study provoked compensatory postural adjustments (CPAs) in a conflicting sensory paradigm with unpredictable visual displacements using virtual reality goggles. METHODS: We used kinematic time-frequency analyses of two frequency bands: a low-frequency band (LB; 0.3-1.5 Hz; mechanical strategy) and a high-frequency band (HB; 1...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Leo Boelaarts, Philip Scheltens, Jos de Jonghe
BACKGROUND AND AIM: Data showing the usefulness of MRI to improve the accuracy of the diagnostic process in cognitive disorders were derived from studies in tertiary referral centers. MRI is widely used as a diagnostic tool in everyday practice, but it is unknown what the actual added value of MRI is. We studied the usefulness of MRI in the diagnostic process by measuring the change of confidence of the physician. METHODS: Physicians indicated confidence in their diagnosis before and after presentation of MR images using a visual analogue scale from 0-100%...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
William Reginold, Angela C Luedke, Justine Itorralba, Juan Fernandez-Ruiz, Omar Islam, Angeles Garcia
BACKGROUND/AIMS: Superficial white matter provides extensive cortico-cortical connections. This tractography study aimed to assess the diffusion characteristics of superficial white matter tracts in Alzheimer's disease. METHODS: Diffusion tensor 3T magnetic resonance imaging scans were acquired in 24 controls and 16 participants with Alzheimer's disease. Neuropsychological test scores were available in some participants. Tractography was performed by the Fiber Assignment by Continuous Tracking (FACT) method...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Min-Ji Kim, Chang-Wan Han, Kyoung-Youn Min, Chae-Yoon Cho, Chae-Won Lee, Yoshiko Ogawa, Etsuro Mori, Masahiro Kohzuki
AIMS: This study aimed to investigate the effect of 6-month physical exercise with a multicomponent cognitive program (MCP) on the cognitive function of older adults with moderate to severe Alzheimer's disease (AD). METHODS: We included 33 participants with AD in a 6-month randomized controlled trial. The intervention group participated in physical exercise and received a MCP. The control group received only the MCP. Before and after the intervention, cognitive outcomes were assessed using the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog), Mini-Mental State Examination, and the Clock Drawing Test...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Hee-Jin Kim, Kyoung Hue Choi, Seung H Kim, Jeffrey L Cummings, Dong-Won Yang
AIM: This study aims to provide a brief questionnaire form of the Neuropsychiatric Inventory (NPI-Q) in Korean translated from the original NPI-Q that is intended for the evaluation of behavioral and psychological symptoms of dementia in routine clinical practice. PATIENTS AND METHODS: We developed a Korean version of the NPI-Q (KNPI-Q) and compared subitems with those of the Korean version of the NPI (KNPI) in 63 dementia patients; 47 patients had been diagnosed with Alzheimer's disease with dementia, 8 with vascular dementia, and 8 with dementia with Lewy body disease...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Jennifer M Harris, Matthew Jones, Claire Gall, Anna M T Richardson, David Neary, Daniel du Plessis, Piyali Pal, David M A Mann, Julie S Snowden, Jennifer C Thompson
BACKGROUND/OBJECTIVES: We aimed to evaluate the co-occurrence of language and behavioural impairment in patients with frontotemporal lobar degeneration (FTLD) spectrum pathology. METHODS: Eighty-one dementia patients with pathological confirmation of FTLD were identified. Anonymized clinical records from patients' first assessment were rated for language and behavioural features from frontotemporal dementia consensus criteria, primary progressive aphasia (PPA) criteria and 1998 FTLD criteria...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
Kiyotaka Nakamagoe, Kotarou Kadono, Tadachika Koganezawa, Mao Takiguchi, Makoto Terada, Fumiko Yamamoto, Tetsuya Moriyama, Kumi Yanagiha, Seitaro Nohara, Naoki Tozaka, Zenshi Miyake, Satoshi Aizawa, Kentaro Furusho, Akira Tamaoka
BACKGROUND: No studies to date have attempted to evaluate frontotemporal lobar degeneration from the perspective of the vestibular system. OBJECTIVE: The present study examined vestibular function in patients with frontotemporal dementia (FTD) clinical syndrome and evaluated whether vestibular disorders are involved in the clinical symptoms due to FTD. METHODS: Fourteen patients with FTD syndrome, as well as healthy elderly controls without dementia, were included in the present study...
May 2016: Dementia and Geriatric Cognitive Disorders Extra
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