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Dementia and Geriatric Cognitive Disorders Extra

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https://www.readbyqxmd.com/read/28626471/early-versus-late-onset-alzheimer-disease-long-term-functional-outcomes-nursing-home-placement-and-risk-factors-for-rate-of-progression
#1
Carina Wattmo, Åsa K Wallin
BACKGROUND/AIMS: Whether age at onset influences functional deterioration in Alzheimer disease (AD) is unclear. We, therefore, investigated risk factors for progression in activities of daily living (ADL) and nursing home placement (NHP) in cholinesterase inhibitor (ChEI)-treated patients with early-onset AD (EOAD) versus late-onset AD (LOAD). METHODS: This 3-year, prospective, observational, multicenter study included 1,017 participants with mild-to-moderate AD; 143 had EOAD (onset <65 years) and 874 LOAD (onset ≥65 years)...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28626470/multi-infarct-dementia-a-historical-perspective
#2
REVIEW
Erin McKay, Scott E Counts
BACKGROUND: Multi-infarct dementia (MID), a prominent subtype of vascular dementia (VaD), has only achieved recognition in the last 4 decades. Since its original description, the characterization, etiological understanding, and therapeutic direction of MID and other VaD subtypes has progressed at an astounding rate. SUMMARY: This paper divides the landmark discoveries and emergence of new research strategies for MID into decade-defining patterns so that a condensed picture of the total history of MID and its eventual inclusion as a VaD subtype emerges...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28626469/serum-amino-acid-profiles-in-normal-subjects-and-in-patients-with-or-at-risk-of-alzheimer-dementia
#3
Gaetano Corso, Adriana Cristofano, Nadia Sapere, Giancarlo la Marca, Antonella Angiolillo, Michela Vitale, Roberto Fratangelo, Teresa Lombardi, Carola Porcile, Mariano Intrieri, Alfonso Di Costanzo
BACKGROUND/AIMS: Abnormalities in the plasma amino acid profile have been reported in Alzheimer disease (AD), but no data exist for the prodromal phase characterized by subjective memory complaint (SMC). It was our aim to understand if serum amino acid levels change along the continuum from normal to AD, and to identify possible diagnostic biomarkers. METHODS: Serum levels of 15 amino acids and 2 organic acids were determined in 4 groups of participants - 29 with probable AD, 18 with mild cognitive impairment (MCI), 24 with SMC, and 46 cognitively healthy subjects (HS) - by electrospray tandem mass spectrometry...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28626468/efficacy-and-safety-of-mlc601-in-the-treatment-of-mild-cognitive-impairment-a-pilot-randomized-double-blind-placebo-controlled-study
#4
Hossein Pakdaman, Ali Amini Harandi, Mehdi Abbasi, Hosein Delavar Kasmaei, Farzad Ashrafi, Koroush Gharagozli, Farhad Assarzadegan, Behdad Behnam, Mehran Arabahmadi
BACKGROUND AND AIM: Mild cognitive impairment (MCI) is characterized by declined cognitive function greater than that expected for a person's age. The clinical significance of this condition is its possible progression to dementia. MLC601 is a natural neuroprotective medication that has shown promising effects in Alzheimer disease. Accordingly, we conducted this randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of MLC601 in MCI patients. METHODS: Seventy-two patients with a diagnosis of MCI were recruited...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28611822/disease-progression-in-mild-dementia-due-to-alzheimer-disease-in-an-18-month-observational-study-geras-the-impact-on-costs-and-caregiver-outcomes
#5
Roy W Jones, Jeremie Lebrec, Kristin Kahle-Wrobleski, Grazia Dell'Agnello, Giuseppe Bruno, Bruno Vellas, Josep M Argimon, Richard Dodel, Josep Maria Haro, Anders Wimo, Catherine Reed
BACKGROUND/AIMS: We assessed whether cognitive and functional decline in community-dwelling patients with mild Alzheimer disease (AD) dementia were associated with increased societal costs and caregiver burden and time outcomes. METHODS: Cognitive decline was defined as a ≥3-point reduction in the Mini-Mental State Examination and functional decline as a decrease in the ability to perform one or more basic items of the Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory (ADCS-ADL) or ≥20% of instrumental ADL items...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28611821/patients-with-mild-cognitive-impairment-show-lower-visual-short-term-memory-performance-in-feature-binding-tasks
#6
Raju P Sapkota, Ian van der Linde, Nirmal Lamichhane, Tirthalal Upadhyaya, Shahina Pardhan
BACKGROUND: Early cognitive changes in people at risk of developing dementia may be detected using behavioral tests that examine the performance of typically affected brain areas, such as the hippocampi. An important cognitive function supported by the hippocampi is memory binding, in which object features are associated to create a unified percept. AIM: To compare visual short-term memory (VSTM) binding performance for object names, locations, and identities between a participant group known to be at higher risk of developing dementia (mild cognitive impairment [MCI]) and healthily aging controls...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28611820/white-matter-disruption-and-connected-speech-in-non-fluent-and-semantic-variants-of-primary-progressive-aphasia
#7
Karine Marcotte, Naida L Graham, Kathleen C Fraser, Jed A Meltzer, David F Tang-Wai, Tiffany W Chow, Morris Freedman, Carol Leonard, Sandra E Black, Elizabeth Rochon
Differential patterns of white matter disruption have recently been reported in the non-fluent (nfvPPA) and semantic (svPPA) variants of primary progressive aphasia (PPA). No single measure is sufficient to distinguish between the PPA variants, but connected speech allows for the quantification of multiple measures. The aim of the present study was to further investigate the white matter correlates associated with connected speech features in PPA. We examined the relationship between white matter metrics and connected speech deficits using an automated analysis of transcriptions of connected speech and diffusion tensor imaging in language-related tracts...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28553314/effect-of-the-sonas-programme-on-communication-in-people-with-dementia-a-randomized-controlled-trial
#8
Benedicte Sørensen Strøm, Knut Engedal, Jurate Saltyte Benth, Ellen-Karine Grov
BACKGROUND: Strategies to improve communication in people with dementia are warranted. We examined the effect of the Sonas programme on communication ability in persons with moderate to severe dementia. METHODS: A 24-week 3-armed (Sonas, reading, and control group) randomized controlled trial including 120 nursing home residents with dementia was conducted; 105 completed the follow-up assessments. The main outcome was change in communication abilities measured by the Holden Communication Scale (HCS)...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28553313/associations-between-pain-and-quality-of-life-in-severe-dementia-a-norwegian-cross-sectional-study
#9
Hanne Marie Rostad, Martine T E Puts, Milada Cvancarova Småstuen, Ellen Karine Grov, Inger Utne, Liv Halvorsrud
BACKGROUND/AIMS: Many variables influence the quality of life in older adults with dementia. We aim to quantify how the relationship between pain and quality of life in nursing home residents with severe dementia can be explained by neuropsychiatric symptoms, depressive symptoms, and activities of daily living. METHODS: This article presents cross-sectional baseline data from a cluster randomised controlled trial. RESULTS: The total and direct effects of pain on quality of life were statistically significant...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28553312/gender-differences-in-verbal-and-visuospatial-working-memory-tasks-in-patients-with-mild-cognitive-impairment-and-alzheimer-disease
#10
M Rosa Elosúa, María José Ciudad, María José Contreras
BACKGROUND/AIMS: To date, there are few studies on gender differences in patients with mild cognitive impairment (MCI) and Alzheimer disease (AD). In the present study, the existence of differences between sexes in verbal and visuospatial working memory tasks in the evolution of cognitive and pathological aging was examined. METHOD: Ninety participants took part in this study: 30 AD, 30 MCI, and 30 healthy elderly participants (50% men and 50% women). RESULTS: There were no significant differences between men and women with AD in visuospatial tasks, whereas these differences were found within the MCI group, with the average of men achieving significantly higher results than women...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28413415/effects-of-nursing-home-residency-on-diabetes-care-in-individuals-with-dementia-an-explorative-analysis-based-on-german-claims-data
#11
Larissa Schwarzkopf, Rolf Holle, Michaela Schunk
AIMS: This claims data-based study compares the intensity of diabetes care in community dwellers and nursing home residents with dementia. METHODS: Delivery of diabetes-related medical examinations (DRMEs) was compared via logistic regression in 1,604 community dwellers and 1,010 nursing home residents with dementia. The intra-individual effect of nursing home transfer was evaluated within mixed models. RESULTS: Delivery of DRMEs decreases with increasing care dependency, with more community-living individuals receiving DRMEs...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28413414/comedication-and-treatment-length-in-users-of-acetylcholinesterase-inhibitors
#12
Anne Sverdrup Efjestad, Hege Ihle-Hansen, Vidar Hjellvik, Hege Salvesen Blix
BACKGROUND/AIMS: Reduced clinical effect on cognitive decline in dementia by acetylcholinesterase inhibitors (AChEIs) may be due to concurrent use of drugs with anticholinergic properties. The aim was to analyze the incidence of AChEI use and comedication with drugs with anticholinergic properties and other potential unfavorable effects. METHODS: A prospective study applying drug use data from the Norwegian Prescription Database. Anticholinergic Drug Scale (ADS) scores were used as a measure of overall anticholinergic burden...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28413413/the-risk-of-incident-mild-cognitive-impairment-and-progression-to-dementia-considering-mild-cognitive-impairment-subtypes
#13
Tzeyu L Michaud, Dejun Su, Mohammad Siahpush, Daniel L Murman
BACKGROUND: It remains unclear how demographic and clinical characteristics are related to the risk of incident mild cognitive impairment (MCI) by its subtypes. Moreover, the contribution of the subtypes of incident MCI to the progression to dementia remains puzzling. METHODS: We used data collected by the National Alzheimer Coordinating Center. Our analysis sample included cognitively normal subjects at baseline. The associations were examined using competing-risks survival regression models and Cox proportional hazards models...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28413412/subjective-cognitive-impairment-is-a-predominantly-benign-condition-in-memory-clinic-patients-followed-for-6-years-the-gothenburg-oslo-mci-study
#14
Erik Hessen, Marie Eckerström, Arto Nordlund, Ina Selseth Almdahl, Jacob Stålhammar, Maria Bjerke, Carl Eckerström, Mattias Göthlin, Tormod Fladby, Ivar Reinvang, Anders Wallin
BACKGROUND/AIMS: In the quest for prevention or treatment, there is a need to find early markers for preclinical dementia. This study observed memory clinic patients with subjective cognitive impairment (SCI) and normal cognitive function at baseline. The primary aim was to address SCI as a potential risk factor for cognitive decline. The secondary aim was to address a potential relation between (1) baseline cerebrospinal fluid biomarkers and (2) a decline in memory performance over the first 2 years of follow-up, with a possible cognitive decline after 6 years...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28203247/elevated-serum-uric-acid-levels-are-related-to-cognitive-deterioration-in-an-elderly-japanese-population
#15
Kazushi Suzuki, Daisuke Koide, Kurumi Fujii, Tsutomu Yamazaki, Shoji Tsuji, Atsushi Iwata
AIMS: The association between serum uric acid (UA) levels and cognitive function is controversial since UA can be a risk factor for cerebral ischemia as well as acting as a neuroprotective antioxidant. METHODS: We conducted a cross-sectional analysis of 228 elderly participants and examined neuropsychological test results, clinical data as well as brain magnetic resonance imaging data. PATIENTS: Overall, 64 participants were diagnosed with cognitive deterioration...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28203246/generalization-of-context-specific-training-in-individuals-with-mild-cognitive-impairment-an-event-related-potential-study
#16
Sam C C Chan, Tommy L H Lam, Kenneth N K Fong, Marco Y C Pang, Chetwyn C H Chan
BACKGROUND: This study examined the neural processes associated with the generalization of the effect of context-specific (CS) training to noncontextual situations among individuals with mild cognitive impairment (MCI). METHODS: Fourteen and 16 participants with MCI were randomly allocated to a Chinese calligraphy writing (CW) training or a control group, respectively. The CW participants learned how to write Chinese strokes in a semicursive style to construct characters, tapping on working memory functions...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28101102/brain-derived-neurotrophic-factor-serum-levels-and-hippocampal-volume-in-mild-cognitive-impairment-and-dementia-due-to-alzheimer-disease
#17
Ericksen Mielle Borba, Juliana Avila Duarte, Giovana Bristot, Ellen Scotton, Ana Luiza Camozzato, Márcia Lorena Fagundes Chaves
BACKGROUND/AIMS: Hippocampal atrophy is a recognized biomarker of Alzheimer disease (AD) pathology. Serum brain-derived neurotrophic factor (BDNF) reduction has been associated with neurodegeneration. We aimed to evaluate BDNF serum levels and hippocampal volume in clinical AD (dementia and mild cognitive impairment [MCI]). METHODS: Participants were 10 patients with MCI and 13 with dementia due to AD as well as 10 healthy controls. BDNF serum levels were determined by ELISA and volumetric measures with NeuroQuant®...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28101101/predictive-factors-of-rapid-cognitive-decline-in-patients-with-alzheimer-disease
#18
Coralie Barbe, Isabella Morrone, J L Novella, Moustapha Dramé, Aurore Wolak-Thierry, Jean-Pierre Aquino, Joël Ankri, Damien Jolly, Rachid Mahmoudi
AIM: To determine predictive factors associated with rapid cognitive decline (RCD) in elderly patients suffering from Alzheimer disease (AD). METHODS: Patients suffering from mild to moderate AD were included. RCD was defined as the loss of at least 3 points on the Mini-Mental State Examination (MMSE) over 12 months. Factors associated with RCD were identified by logistic regression. RESULTS: Among 123 patients included, 61 were followed up until 12 months...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28101100/the-utility-of-the-mini-addenbrooke-s-cognitive-examination-as-a-screen-for-cognitive-impairment-in-elderly-patients-with-chronic-kidney-disease-and-diabetes
#19
Peter Hobson, Kamel H Rohoma, Stephen P Wong, Mick J Kumwenda
BACKGROUND/AIMS: We tested the utility of the Mini-Addenbrooke's Cognitive Examination (M-ACE) in a cohort of older adults with chronic kidney disease (CKD) and diabetes. METHOD: The M-ACE was administered to 112 CKD and diabetes patients attending a nephrology clinic. Cognitive impairment was based upon patient, informant, and case review, neuropsychological assessment, and application of criteria for mild cognitive impairment (MCI) and the Diagnostic and Statistical Manual of Mental Disorders, fifth edition for dementia...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28101099/magnetic-resonance-volumetry-prediction-of-subjective-memory-complaints-and-mild-cognitive-impairment-and-associations-with-genetic-and-cardiovascular-risk-factors
#20
Sigbjørn Rogne, Torgil Vangberg, Petter Eldevik, Gry Wikran, Ellisiv B Mathiesen, Henrik Schirmer
BACKGROUND/AIMS: Subjective memory complaints (SMC) are strong predictors of mild cognitive impairment (MCI) and subsequent Alzheimer's disease. Our aims were to see if fully automated cerebral MR volume measurements could distinguish subjects with SMC and MCI from controls, and if probable parental late-onset Alzheimer's disease (LOAD), apolipoprotein E ε4 genotype, total plasma homocysteine, and cardiovascular risk factors were associated with MR volumetric findings. METHODS: 198 stroke-free subjects comprised the control (n = 58), the SMC (n = 25) and the MCI (n = 115) groups...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
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