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Dementia and Geriatric Cognitive Disorders Extra

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https://www.readbyqxmd.com/read/29118786/the-cognitive-telephone-screening-instrument-cogtel-a-brief-reliable-and-valid-tool-for-capturing-interindividual-differences-in-cognitive-functioning-in-epidemiological-and-aging-studies
#1
Andreas Ihle, Élvio R Gouveia, Bruna R Gouveia, Matthias Kliegel
Aims: The present study set out to evaluate the psychometric properties of the Cognitive Telephone Screening Instrument (COGTEL) in 2 different samples of older adults. Methods: We assessed COGTEL in 116 older adults, with retest after 7 days to evaluate the test-retest reliability. Moreover, we assessed COGTEL in 868 older adults to evaluate convergent validity to the Mini-Mental State Examination (MMSE). Results: Test-retest reliability of the COGTEL total score was good at 0...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29118785/advance-directives-as-support-of-autonomy-for-persons-with-dementia-a-pilot-study-among-persons-with-dementia-and-their-informal-caregivers
#2
Martina Schmidhuber, Sandra Haeupler, Velislava Marinova-Schmidt, Andreas Frewer, Peter L Kolominsky-Rabas
Background: Advance directives could be an important instrument to support a person's will once he/she is not able to consent anymore - if composed competently. A survey was conducted to identify the level of knowledge concerning possibilities and limits of advance directives. Methods: The study was conducted as part of the Bavarian Dementia Survey (BayDem). Data were collected from January 2014 to December 2015 by structured face-to-face interviews. Study participants were persons with dementia and their informal caregivers (n = 74)...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29118784/montreal-cognitive-assessment-in-a-63-to-65-year-old-norwegian-cohort-from-the-general-population-data-from-the-akershus-cardiac-examination-1950-study
#3
Håkon Ihle-Hansen, Thea Vigen, Trygve Berge, Gunnar Einvik, Dag Aarsland, Ole Morten Rønning, Bente Thommessen, Helge Røsjø, Arnljot Tveit, Hege Ihle-Hansen
Aims: To investigate Montreal Cognitive Assessment (MoCA) test scores in a cohort aged 63-65 years from a general population in relation to the proposed cut-off score of 26 for mild cognitive impairment (MCI) and to explore the impact of education. Methods: MoCA scores were assessed in the Akershus Cardiac Examination 1950 Study, a cross-sectional cohort study of all men and women born in 1950 living in Akershus County, Norway. The participants were aged 63-65 at the time of data collection...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29118783/cerebrospinal-fluid-phosphate-in-delirium-after-hip-fracture
#4
Ane-Victoria Idland, Torgeir Bruun Wyller, Randi Støen, Gry Torsæter Dahl, Frede Frihagen, Anne Brækhus, Bjørnar Hassel, Leiv Otto Watne
Aims: Phosphate is essential for neuronal activity. We aimed to investigate whether delirium is associated with altered phosphate concentrations in cerebrospinal fluid (CSF) and serum. Methods: Seventy-seven patients with hip fracture were assessed for delirium before and after acute surgery. Prefracture dementia was diagnosed by an expert panel. Phosphate was measured in CSF obtained immediately before spinal anesthesia (n = 77) and in serum (n = 47). CSF from 23 cognitively healthy elderly patients undergoing spinal anesthesia was also analyzed...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29118782/influence-of-mild-cognitive-impairment-depression-and-anxiety-on-the-quality-of-life-of-patients-with-parkinson-disease
#5
Daniel Wiesli, Antonia Meyer, Peter Fuhr, Ute Gschwandtner
Background: Neuropsychiatric symptoms (NPS) and mild cognitive impairment (MCI) are common in Parkinson disease (PD) and have a negative impact on the patient's quality of life (QoL). We aim to describe the effect of NPS and MCI on each other and on QoL. Methods: Sixteen MCI and 37 non-MCI PD patients completed different self-assessment questionnaires including the Parkinson's Disease Questionnaire (PDQ-39), the Beck Depression Inventory (BD), the Beck Anxiety Inventory (BAI), and the Self-Report Manic Inventory (SRMI)...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29033974/cognitive-deficits-in-chronic-stroke-patients-neuropsychological-assessment-depression-and-self-reports
#6
Arne E Nakling, Dag Aarsland, Halvor Næss, Daniel Wollschlaeger, Tormod Fladby, Håkon Hofstad, Eike Wehling
BACKGROUND: Following stroke, clinicians are challenged to detect and untangle symptoms of cognitive dysfunction and mood disorders. Additionally, they need to evaluate the informative value of self-reports to identify patients in need of further attendance. AIMS: To examine the association between neuropsychological measures, symptoms of depression, and self-reported cognitive function. METHODS: One-hundred and five chronic stroke patients underwent assessment covering 6 cognitive domains and answered the Hospital Anxiety and Depression Scale and the Memory and Thinking Scale from the Stroke Impact Scale 1 year after stroke...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29033973/comparison-of-central-ambulatory-home-and-office-blood-pressure-measurement-as-risk-markers-for-mild-cognitive-impairment-in-hypertensive-patients
#7
Teodora Yaneva-Sirakova, Latchezar Traykov, Julia Petrova, Dobrin Vassilev
AIMS: We compared the role of central blood pressure (BP), ambulatory BP monitoring (ABPM), home-measured BP (HMBP) and office BP measurement as risk markers for the development of mild cognitive impairment (MCI). METHODS: 70 hypertensive patients on combination medical therapy were studied. Their mean age was 64.97 ± 8.88 years. Eighteen (25.71%) were males and 52 (74.28%) females. All of the patients underwent full physical examination, laboratory screening, echocardiography, and office, ambulatory, home and central BP measurement...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29033972/clinical-spectrum-risk-factors-and-behavioral-abnormalities-among-dementia-subtypes-in-a-north-indian-population-a-hospital-based-study
#8
Suman Kushwaha, Puneet Talwar, Aldrin Anthony, Meena Gupta, Kiran Bala, Rachna Agarwal, Vibha Sharma, Ritushree Kukreti
BACKGROUND: As variability in the clinical profile of dementia subtypes had been reported with regional differences across the world, we conducted a retrospective hospital-based study in a North Indian population. METHODS: We retrieved patient records from 2007 to 2014 for details of clinical evaluation, diagnosis, neuroimaging, biochemical investigations, and follow-up of 1,876 patients with dementia (PwD), and the data were analyzed using descriptive statistics...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28868068/assessing-capacity-in-the-elderly-comparing-the-moca-with-a-novel-computerized-battery-of-executive-function
#9
Megan Brenkel, Kenneth Shulman, Elias Hazan, Nathan Herrmann, Adrian M Owen
BACKGROUND/AIMS: Clinicians are increasingly being asked to provide their opinion on the decision-making capacity of older adults, while validated and widely available tools are lacking. We sought to identify an online cognitive screening tool for assessing mental capacity through the measurement of executive function. METHODS: A mixed elderly sample of 45 individuals, aged 65 years and older, were screened with the Montreal Cognitive Assessment (MoCA) and the modified Cambridge Brain Sciences Battery...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28868067/cerebrospinal-fluid-apolipoprotein-e-levels-in-delirium
#10
Gideon A Caplan, JIan Tai, Fazrul Mohd Hanizan, Catherine L McVeigh, Mark A Hill, Anne Poljak
BACKGROUND/AIMS: Delirium and the apolipoprotein E ε4 allele are risk factors for late-onset Alzheimer disease (LOAD), but the connection is unclear. We looked for an association. METHODS: Inpatients with delirium (n = 18) were compared with LOAD outpatients (n = 19), assaying blood and cerebrospinal fluid (CSF) using multiplex ELISA. RESULTS: The patients with delirium had a higher Confusion Assessment Method (CAM) score (5.6 ± 1.2 vs. 0...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28868066/distinguishing-depressive-pseudodementia-from-alzheimer-disease-a-comparative-study-of-hippocampal-volumetry-and-cognitive-tests
#11
Sevki Sahin, Tugba Okluoglu Önal, Nilgun Cinar, Meral Bozdemir, Rahmi Çubuk, Sibel Karsidag
BACKGROUND AND AIM: Depressive pseudodementia (DPD) is a condition which may develop secondary to depression. The aim of this study was to contribute to the differential diagnosis between Alzheimer disease (AD) and DPD by comparing the neurocognitive tests and hippocampal volume. MATERIALS AND METHODS: Patients who met criteria of AD/DPD were enrolled in the study. All patients were assessed using the Wechsler Memory Scale (WMS), clock-drawing test, Stroop test, Benton Facial Recognition Test (BFRT), Boston Naming Test, Mini-Mental State Examination (MMSE), and Geriatric Depression Scale (GDS)...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28690635/the-development-of-the-dementia-screening-battery-100-instrument-presentation-reliability-and-construct-validity
#12
Tarek Bellaj, Sonia Ben Jemaa, Maher Khelifa, Mona Ben Djebara, Riadh Gouider, Didier Le Gall
BACKGROUND/AIM: The screening of dementia in non-Westerners has so far relied on translations and adaptations of reputed instruments. Other efforts focused on developing culturally appropriate tests or tests in touch with new developments in the field. This study presents the rationale behind the construction of a new dementia screening test: the Dementia Screening Battery-100 (DSB-100). METHODS: The DSB-100 was administered to 46 demented individuals and 159 healthy matched controls...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28690634/preventive-effect-of-rifampicin-on-alzheimer-disease-needs-at-least-450-mg-daily-for-1-year-an-fdg-pet-follow-up-study
#13
Tomomichi Iizuka, Kozo Morimoto, Yuka Sasaki, Masashi Kameyama, Atsuyuki Kurashima, Kazumasa Hayasaka, Hideo Ogata, Hajime Goto
BACKGROUND: Rifampicin was reported to inhibit amyloid-β oligomerization and tau hyperphosphorylation in mouse models and could serve as a promising available medicine for the prevention of Alzheimer disease (AD). To examine whether rifampicin has such preventive effects in humans, we retrospectively reviewed (18)F-FDG-PET findings of elderly patients with mycobacterium infection treated with rifampicin. METHODS: Forty nondemented elderly patients treated with rifampicin for mycobacterium infections who showed AD-type hypometabolism were enrolled...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28690633/how-do-community-dwelling-persons-with-alzheimer-disease-fall-falls-in-the-finalex-study
#14
Niko M Perttila, Hannareeta Öhman, Timo E Strandberg, Hannu Kautiainen, Minna Raivio, Marja-Liisa Laakkonen, Niina Savikko, Reijo S Tilvis, Kaisu H Pitkala
BACKGROUND: People with dementia are at high risk for falls. However, little is known of the features causing falls in Alzheimer disease (AD). Our aim was to investigate how participants with AD fall. METHODS: In the FINALEX (Finnish Alzheimer Disease Exercise Trial) study, participants' (n = 194) falls were followed up for 1 year by diaries kept by their spouses. RESULTS: The most common reason for falls (n = 355) was stumbling (n = 61). Of the falls, 123 led to injuries, 50 to emergency department visits, and 13 to fractures...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28690632/neuropsychological-differences-related-to-age-in-dementia-with-lewy-bodies
#15
Yasuhiro Nagahama, Tomoko Okina, Norio Suzuki
BACKGROUND/AIMS: To examine the influence of age on neuropsychological performances in dementia with Lewy bodies (DLB) and Alzheimer disease (AD) patients. METHODS: We examined memory, executive, and visuo-constructional performances in 202 DLB patients and 236 AD patients. We divided the subjects into three age groups (65-74, 75-84, and 85-95 years old), and evaluated the differences in neuropsychological performances. RESULTS: Recent memory in the DLB group was significantly better than that in the age-matched AD group when comparing the age groups 65-74 years and 75-84 years; however, memory impairment in the DLB patients in the age group 85-95 years was comparable with that in the age-matched AD patients...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28626471/early-versus-late-onset-alzheimer-disease-long-term-functional-outcomes-nursing-home-placement-and-risk-factors-for-rate-of-progression
#16
Carina Wattmo, Åsa K Wallin
BACKGROUND/AIMS: Whether age at onset influences functional deterioration in Alzheimer disease (AD) is unclear. We, therefore, investigated risk factors for progression in activities of daily living (ADL) and nursing home placement (NHP) in cholinesterase inhibitor (ChEI)-treated patients with early-onset AD (EOAD) versus late-onset AD (LOAD). METHODS: This 3-year, prospective, observational, multicenter study included 1,017 participants with mild-to-moderate AD; 143 had EOAD (onset <65 years) and 874 LOAD (onset ≥65 years)...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28626470/multi-infarct-dementia-a-historical-perspective
#17
REVIEW
Erin McKay, Scott E Counts
BACKGROUND: Multi-infarct dementia (MID), a prominent subtype of vascular dementia (VaD), has only achieved recognition in the last 4 decades. Since its original description, the characterization, etiological understanding, and therapeutic direction of MID and other VaD subtypes has progressed at an astounding rate. SUMMARY: This paper divides the landmark discoveries and emergence of new research strategies for MID into decade-defining patterns so that a condensed picture of the total history of MID and its eventual inclusion as a VaD subtype emerges...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28626469/serum-amino-acid-profiles-in-normal-subjects-and-in-patients-with-or-at-risk-of-alzheimer-dementia
#18
Gaetano Corso, Adriana Cristofano, Nadia Sapere, Giancarlo la Marca, Antonella Angiolillo, Michela Vitale, Roberto Fratangelo, Teresa Lombardi, Carola Porcile, Mariano Intrieri, Alfonso Di Costanzo
BACKGROUND/AIMS: Abnormalities in the plasma amino acid profile have been reported in Alzheimer disease (AD), but no data exist for the prodromal phase characterized by subjective memory complaint (SMC). It was our aim to understand if serum amino acid levels change along the continuum from normal to AD, and to identify possible diagnostic biomarkers. METHODS: Serum levels of 15 amino acids and 2 organic acids were determined in 4 groups of participants - 29 with probable AD, 18 with mild cognitive impairment (MCI), 24 with SMC, and 46 cognitively healthy subjects (HS) - by electrospray tandem mass spectrometry...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28626468/efficacy-and-safety-of-mlc601-in-the-treatment-of-mild-cognitive-impairment-a-pilot-randomized-double-blind-placebo-controlled-study
#19
Hossein Pakdaman, Ali Amini Harandi, Mehdi Abbasi, Hosein Delavar Kasmaei, Farzad Ashrafi, Koroush Gharagozli, Farhad Assarzadegan, Behdad Behnam, Mehran Arabahmadi
BACKGROUND AND AIM: Mild cognitive impairment (MCI) is characterized by declined cognitive function greater than that expected for a person's age. The clinical significance of this condition is its possible progression to dementia. MLC601 is a natural neuroprotective medication that has shown promising effects in Alzheimer disease. Accordingly, we conducted this randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of MLC601 in MCI patients. METHODS: Seventy-two patients with a diagnosis of MCI were recruited...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28611822/disease-progression-in-mild-dementia-due-to-alzheimer-disease-in-an-18-month-observational-study-geras-the-impact-on-costs-and-caregiver-outcomes
#20
Roy W Jones, Jeremie Lebrec, Kristin Kahle-Wrobleski, Grazia Dell'Agnello, Giuseppe Bruno, Bruno Vellas, Josep M Argimon, Richard Dodel, Josep Maria Haro, Anders Wimo, Catherine Reed
BACKGROUND/AIMS: We assessed whether cognitive and functional decline in community-dwelling patients with mild Alzheimer disease (AD) dementia were associated with increased societal costs and caregiver burden and time outcomes. METHODS: Cognitive decline was defined as a ≥3-point reduction in the Mini-Mental State Examination and functional decline as a decrease in the ability to perform one or more basic items of the Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory (ADCS-ADL) or ≥20% of instrumental ADL items...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
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