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Medical Gas Research

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https://www.readbyqxmd.com/read/29152217/anesthetic-induced-developmental-neurotoxicity-causes-prospective-studies-and-possible-interventions
#1
Abhijit S Nair, Kaushik Pulipaka, Basanth Kumar Rayani
No abstract text is available yet for this article.
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29152216/macrophage-polarization-is-related-to-the-pathogenesis-of-decompression-induced-lung-injury
#2
REVIEW
Cui-Hong Han, Pei-Xi Zhang, Wen-Wu Liu
Studies have shown that blood bubbles may be detectable and there is ultrasonic evidence of acute interstitial lung edema even after diving without protocol violation. Macrophages play a central role in the inflammation, and macrophage polarization is closely related to the pathogenesis some lung diseases. Available findings indicate that decompression may induce the production of pro-inflammatory cytokines, chemokines, and adhesion molecules in the blood and tissues, which are associated with the macrophage polarization, and hyperbaric treatment may exert therapeutic effects on decompression related diseases via regulating these factors...
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29152215/ozone-therapy-an-overview-of-pharmacodynamics-current-research-and-clinical-utility
#3
REVIEW
Noel L Smith, Anthony L Wilson, Jason Gandhi, Sohrab Vatsia, Sardar Ali Khan
The use of ozone (O3) gas as a therapy in alternative medicine has attracted skepticism due to its unstable molecular structure. However, copious volumes of research have provided evidence that O3's dynamic resonance structures facilitate physiological interactions useful in treating a myriad of pathologies. Specifically, O3 therapy induces moderate oxidative stress when interacting with lipids. This interaction increases endogenous production of antioxidants, local perfusion, and oxygen delivery, as well as enhances immune responses...
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29152214/anesthetic-effects-on-autophagy
#4
REVIEW
Fan Ye, Zhi-Yi Zuo
Anesthetic agents provide patient comfort and optimize conditions for surgical and procedural interventions. These agents have been shown to modulate autophagy, which is a cellular mechanism that maintains tissue homeostasis by degrading and recycling excess, aged, or dysfunctional proteins. However, it is not always clear if upregulated autophagy is beneficial or harmful. This review assesses the anesthetic effects on autophagy. In the vast majority of studies, anesthetic modulation of autophagy is beneficial for cell survival...
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29152213/the-role-of-nitric-oxide-in-stroke
#5
REVIEW
Zhou-Qing Chen, Ru-Tao Mou, Dong-Xia Feng, Zhong Wang, Gang Chen
Stroke is considered to be an acute cerebrovascular disease, including ischemic stroke and hemorrhagic stroke. The high incidence and poor prognosis of stroke suggest that it is a highly disabling and highly lethal disease which can pose a serious threat to human health. Nitric oxide (NO), a common gas in nature, which is often thought as a toxic gas, because of its intimate relationship with the pathological processes of many diseases, especially in the regulation of blood flow and cell inflammation. However, recent years have witnessed an increased interest that NO plays a significant and positive role in stroke as an essential gas signal molecule...
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29152212/sevoflurane-and-renal-function-a-meta-analysis-of-randomized-trials
#6
Lady Christine L Ong Sio, Richard Glenn C Dela Cruz, Alexander F Bautista
Objective: This study aims to describe the overall cumulative effect of sevoflurane on kidney function in healthy patients in terms of mean plasma creatinine, blood urea nitrogen (BUN), creatinine clearance, urinary protein, and glucose excretion at 24 and 72 hours post-anesthesia. Data retrieval: A systematic literature search using MEDLINE and EMBASE as primary search engines was conducted. Articles, relevant abstracts, and citations dated January 1, 1995 to June 30, 2016 were retrieved...
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29152211/xenon-helium-gas-mixture-at-equimolar-concentration-of-37-5-protects-against-oxygen-and-glucose-deprivation-induced-injury-and-inhibits-tissue-plasminogen-activator
#7
Hélène N David, Benoit Haelewyn, Jean-Éric Blatteau, Jean-Jacques Risso, Nicolas Vallée, Jacques H Abraini
Xenon (Xe) is considered to be the golden standard neuroprotective gas. However, Xe has a higher molecular weight and lower thermal conductivity and specific heat than those of nitrogen, the main diluent of oxygen in air. These physical characteristics could impair or at least reduce the intrinsic neuroprotective action of Xe by increasing the patient's respiratory workload and body temperature. In contrast, helium (He) is a cost-efficient gas with a lower molecular weight and higher thermal conductivity and specific heat than those of nitrogen, but is far less potent than Xe...
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29152210/a-method-for-calculating-the-gas-volume-proportions-and-inhalation-temperature-of-inert-gas-mixtures-allowing-reaching-normothermic-or-hypothermic-target-body-temperature-in-the-awake-rat
#8
Jacques H Abraini, Hélène N David, Jean-Éric Blatteau, Jean Jacques Risso, Nicolas Vallée
The noble gases xenon (Xe) and helium (He) are known to possess neuroprotective properties. Xe is considered the golden standard neuroprotective gas. However, Xe has a higher molecular weight and lower thermal conductivity and specific heat than those of nitrogen, the main diluent of oxygen (O2) in air, conditions that could impair or at least reduce the intrinsic neuroprotective properties of Xe by increasing the critical care patient's respiratory workload and body temperature. In contrast, He has a lower molecular weight and higher thermal conductivity and specific heat than those of nitrogen, but is unfortunately far less potent than Xe at providing neuroprotection...
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29152209/case-control-study-hyperbaric-oxygen-treatment-of-mild-traumatic-brain-injury-persistent-post-concussion-syndrome-and-post-traumatic-stress-disorder
#9
Paul G Harch, Susan R Andrews, Edward F Fogarty, Juliette Lucarini, Keith W Van Meter
Mild traumatic brain injury (TBI) persistent post-concussion syndrome (PPCS) and post-traumatic stress disorder (PTSD) are epidemic in United States Iraq and Afghanistan War veterans. Treatment of the combined diagnoses is limited. The aim of this study is to assess safety, feasibility, and effectiveness of hyperbaric oxygen treatments (HBOT) for mild TBI PPCS and PTSD. Thirty military subjects aged 18-65 with PPCS with or without PTSD and from one or more blast-induced mild-moderate traumatic brain injuries that were a minimum of 1 year old and occurred after 9/11/2001 were studied...
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29152208/correction-argon-attenuates-the-emergence-of-secondary-injury-after-traumatic-brain-injury-within-a-2-hour-incubation-period-compared-to-desflurane-an-in-vitro-study
#10
(no author information available yet)
[This corrects the article on p. 93 in vol. 7, PMID: 28744361.].
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29152207/endotracheal-intubation-in-patients-with-difficult-airway-using-laryngeal-mask-airway-with-bougie-versus-video-laryngoscopy
#11
Hesameddin Modir, Esmail Moshiri, Bita Malekianzadeh, Gholamreza Noori, Abolfazl Mohammadbeigi
Airway management is essential for safe anesthesia and endotracheal intubation is the most important procedure by which critically ill patients can be better managed, especially if done quickly and successfully. This study aimed to compare the techniques of intubation through laryngeal mask airway (LMA) using a bougie versus video laryngoscopy (VL) regarding to intubation success and the quality of intubation indices in patients with difficult airways. This randomized clinical trial was performed on 96 patients aged 16-76 years with Mallampati class 3 or 4 who underwent elective surgery...
July 2017: Medical Gas Research
https://www.readbyqxmd.com/read/28744361/argon-attenuates-the-emergence-of-secondary-injury-after-traumatic-brain-injury-within-a-2-hour-incubation-period-compared-to-desflurane-an-in-vitro-study
#12
Linda Grüßer, Rosmarie Blaumeiser-Debarry, Matthias Krings, Benedikt Kremer, Anke Höllig, Rolf Rossaint, Mark Coburn
Despite years of research, treatment of traumatic brain injury (TBI) remains challenging. Considerable data exists that some volatile anesthetics might be neuroprotective. However, several studies have also revealed a rather neurotoxic profile of anesthetics. In this study, we investigated the effects of argon 50%, desflurane 6% and their combination in an in vitro TBI model with incubation times similar to narcotic time slots in a daily clinical routine. Organotypic hippocampal brain slices of 5- to 7-day-old mice were cultivated for 14 days before TBI was performed...
April 2017: Medical Gas Research
https://www.readbyqxmd.com/read/28480035/meeting-report-6-th-negative-hydrogen-ions-international-academic-forum
#13
He Li, Ning Zhang, Ou-Yang Chen
No abstract text is available yet for this article.
January 2017: Medical Gas Research
https://www.readbyqxmd.com/read/28480034/co-administration-of-tissue-plasminogen-activator-and-hyperbaric-oxygen-in-ischemic-stroke-a-continued-promise-for-neuroprotection
#14
REVIEW
Ze-Song Yang, Jun Mu
Intravenous recombinant tissue-type plasminogen activator (r-tPA, alteplase) remains the recommended therapy for acute ischemic stroke. However, several factors are limiting its practical use. It makes it urgent for us to search more efficient strategies that can save the ischemic neurons, and safely extend the time window, while in the mean time reducing the detrimental effects for stroke thrombolysis. Hyperbaric oxygen therapy (HBOT) is considered to be potentially neuroprotective. Co-administration of r-tPA and HBOT has already been proved to be effective, safe and feasible in myocardial infarction...
January 2017: Medical Gas Research
https://www.readbyqxmd.com/read/28480033/in-vivo-electron-paramagnetic-resonance-oximetry-and-applications-in-the-brain
#15
REVIEW
John M Weaver, Ke Jian Liu
Molecular oxygen (O2) is essential to brain function and mechanisms necessary to regulate variations in delivery or utilization of O2 are crucial to support normal brain homeostasis, physiology and energy metabolism. Any imbalance in cerebral tissue partial pressure of O2 (pO2) levels may lead to pathophysiological complications including increased reactive O2 species generation leading to oxidative stress when tissue O2 level is too high or too low. Accordingly, the need for oximetry methods, which assess cerebral pO2in vivo and in real time, is imperative to understand the role of O2 in various metabolic and disease states, including the effects of treatment and therapy options...
January 2017: Medical Gas Research
https://www.readbyqxmd.com/read/28480032/neuroprotection-provided-by-isoflurane-pre-conditioning-and-post-conditioning
#16
REVIEW
Ming Jiang, Liang Sun, Dong-Xia Feng, Zheng-Quan Yu, Rong Gao, Yuan-Zhao Sun, Gang Chen
Isoflurane, a volatile and inhalational anesthetic, has been extensively used in perioperative period for several decades. A large amount of experimental studies have indicated that isoflurane exhibits neuroprotective properties when it is administrated before or after (pre-conditioning and post-conditioning) neurodegenerative diseases (e.g., hypoxic ischemia, stroke and trauma). Multiple mechanisms are involved in isoflurane induced neuroprotection, including activation of glycine and γ-aminobutyric acid receptors, antagonism of ionic channels and alteration of the function and activity of other cellular proteins...
January 2017: Medical Gas Research
https://www.readbyqxmd.com/read/28480031/carbon-monoxide-as-a-promising-molecule-to-promote-nerve-regeneration-after-traumatic-brain-injury
#17
REVIEW
Liang Qiao, Ning Zhang, Jun-Long Huang, Xiang-Qun Yang
Carbon monoxide (CO) is known as a toxic gas. Although there have been many studies on both toxic and protective effects of CO, most of these studies lack novelty, except for Eng H Lo team's study on the therapeutic effect of CO on brain injuries. In this commentary, we summarize the potential application value of CO in the treatment of some clinical diseases, especially its protective effect and nerve regeneration in brain injuries, hoping that our interest in CO could promote related clinical application studies...
January 2017: Medical Gas Research
https://www.readbyqxmd.com/read/28480030/drug-enhanced-carbon-monoxide-production-from-heme-by-cytochrome-p450-reductase
#18
Dragic Vukomanovic, Mona N Rahman, Zongchao Jia, Kanji Nakatsu
Carbon monoxide (CO) formed endogenously is considered to be cytoprotective, and the vast majority of CO formation is attributed to the degradation of heme by heme oxygenases-1 and -2 (HO-1, HO-2). Previously, we observed that brain microsomes containing HO-2 produced many-fold more CO in the presence of menadione and its congeners; herein we explored these observations further. We determined the effects of various drugs on CO production of rat brain microsomes and recombinant human cytochrome P450 reductase (CPR); CO was measured by gas chromatography with reductive detection...
January 2017: Medical Gas Research
https://www.readbyqxmd.com/read/28480029/a-porcine-ex-vivo-lung-perfusion-model-with-maximal-argon-exposure-to-attenuate-ischemia-reperfusion-injury
#19
An Martens, Sofie Ordies, Bart M Vanaudenaerde, Stijn E Verleden, Robin Vos, Geert M Verleden, Eric K Verbeken, Dirk E Van Raemdonck, Sandra Claes, Dominique Schols, Matthieu Chalopin, Ira Katz, Geraldine Farjot, Arne P Neyrinck
Argon (Ar) is a noble gas with known organoprotective effects in rodents and in vitro models. In a previous study we failed to find a postconditioning effect of Ar during ex vivo lung perfusion (EVLP) on warm-ischemic injury in a porcine model. In this study, we further investigated a prolonged exposure to Ar to decrease cold ischemia-reperfusion injury after lung transplantation in a porcine model with EVLP assessment. Domestic pigs (n = 6/group) were pre-conditioned for 6 hours with 21% O2 and 79% N2 (CONTR) or 79% Ar (ARG)...
January 2017: Medical Gas Research
https://www.readbyqxmd.com/read/28480028/a-comparison-of-renal-responses-to-sevoflurane-and-isoflurane-in-patients-undergoing-donor-nephrectomy-a-randomized-controlled-trial
#20
Lady Christine L Ong Sio, Richard Glenn C Dela Cruz, Alexander F Bautista
Sevoflurane and isoflurane are volatile halogenated ether widely used in anesthesia. Both have comparable potency and easy titratability but sevoflurane has lower pungency and results in faster patient recovery. Isoflurane, however, is more affordable. The nephrotoxicity of sevoflurane is undisputed but studies on isoflurane nephrotoxicity are lacking. The objective of this paper is to determine the overall nephrotoxicity profile of sevoflurane and isoflurane in donor nephrectomy patients using the renal function markers - nuclear glomerular filtration rate (GFR), serum creatinine, urine protein-to-creatinine ratio, proteinuria, and glucosuria...
January 2017: Medical Gas Research
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