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American Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/30042872/hepato-splenic-axis-hepatic-and-splenic-metabolic-activities-are-linked
#1
Georgia Keramida, Alexander Dunford, Guven Kaya, Constantinos D Anagnostopoulos, Adrien Michael Peters
The concept of a hepato-splenic axis has recently been put forward. We aimed to investigate whether hepatic and splenic metabolic activities are linked, and if splenic metabolic activity is increased in non-alcoholic fatty liver disease (NAFLD). Blood clearance rates of phosphorylated 18 F-fluorodeoxyglucose were measured in the spleen and liver from dynamic PET using Gjedde-Patlak-Rutland graphical analysis and abdominal aorta for input function in 59 patients undergoing routine PET/CT. Plot gradient (Ki), which represents blood clearance, was divided by intercept (V(0)), which represents tissue FDG distribution volume, and multiplied by blood glucose to give glucose uptake rate per unit tracer distribution volume (MRglu)...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30042871/searching-for-novel-pet-radiotracers-imaging-cardiac-perfusion-metabolism-and-inflammation
#2
REVIEW
Caitlund Q Davidson, Christopher P Phenix, T C Tai, Neelam Khaper, Simon J Lees
Advances in medical imaging technology have led to an increased demand for radiopharmaceuticals for early and accurate diagnosis of cardiac function and diseased states. Myocardial perfusion, metabolism, and hypoxia positron emission tomography (PET) imaging radiotracers for detection of cardiac disease lack specificity for targeting inflammation that can be an early indicator of cardiac disease. Inflammation can occur at all stages of cardiac disease and currently, 18 F-fluorodeoxyglucose (FDG), a glucose analog, is the standard for detecting myocardial inflammation...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30042870/multimodal-imaging-provides-insight-into-targeted-therapy-response-in-metastatic-prostate-cancer-to-the-bone
#3
Benjamin A Hoff, Jean-Christophe Brisset, Stefanie Galbán, Marcian Van Dort, David C Smith, Zachery R Reichert, Jon A Jacobson, Gary D Luker, Thomas L Chenevert, Brian D Ross
Metastatic prostate cancer to bone remains incurable, driving efforts to develop individualized, targeted therapies to improve clinical outcomes while limiting adverse side-effects. Due to the complexity in cellular signaling pathways and the interaction between cancer and its microenvironment, multiparametric imaging approaches for treatment response may improve understanding of the biological effects of therapy. An orthotopic model of castration resistant prostate cancer (CRPC) bone metastasis was treated with the tyrosine kinase inhibitor Cabozantinib (CABO)...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30042869/x-ray-fluorescence-imaging-of-metals-and-metalloids-in-biological-systems
#4
REVIEW
Run Zhang, Li Li, Yasmina Sultanbawa, Zhi Ping Xu
Metals and metalloids play fundamental roles in many physiological processes in biological systems, but imbalance of these elements in the body may cause many diseases, such as Parkinson's disease, Alzheimer's disease, and even cancers. Thus, to better understand the metallome in health and disease, quantitative determination of their localization, concentration, speciation, and related metabolism at cellular or subcellular levels is of great importance. X-ray fluorescence (XRF) imaging, as a new generation of analytical technique, has been reported as an ideal tool to quantitatively map multiple metals and metalloids in tissues with reasonable sensitivity, specificity, and resolution...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30042868/accuracy-of-whole-body-hdp-spect-ct-fdg-pet-ct-and-their-combination-for-detecting-bone-metastases-in-breast-cancer-an-intra-personal-comparison
#5
Olivier Rager, Stephanie A Lee-Felker, Claire Tabouret-Viaud, Ely R Felker, Antoine Poncet, Gaël Amzalag, Valentina Garibotto, Habib Zaidi, Martin A Walter
New generation SPECT/CT scanners allow rapid whole-body imaging, and potentially facilitate significantly improved diagnostic accuracy. Thus, the aim of this study was to compare the diagnostic accuracy of whole-body Tc-99m-HDP SPECT/CT, F-18-FDG PET/CT, and their combination for detecting bone metastases in breast cancer. Women with biopsy-proven breast cancer that were referred for whole-body SPECT/CT and FDG PET/CT were consecutively included in this retrospective study. Two blinded readers independently interpreted all scans...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30042867/awake-tracheal-intubation-using-combination-of-an-airtraq-%C3%A2-optical-laryngoscope-with-smartphone-and-video-flexible-endoscope-a-case-report
#6
Zhi-Qiang Zhou, Xu Zhao, Hong-Bing Xiang
A patient with obvious difficult airway who was received awake tracheal intubation using combination of an Airtraq® optical laryngoscope with smartphone and video flexible endoscope posted for elective surgery of tonsillectomy for OSAHS was reported. Our experiences strongly indicate that fully communication with patients, detailed preoperative assessment of airways and perfect plan, appropriate endotracheal intubation approach and devices play important roles in awake tracheal intubation in difficult airway...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755848/ct-dose-modulation-using-automatic-exposure-control-in-whole-body-pet-ct-effects-of-scout-imaging-direction-and-arm-positioning
#7
Yusuke Inoue, Kazunori Nagahara, Hiroko Kudo, Hiroyasu Itoh
Automatic exposure control (AEC) modulates tube current and consequently X-ray exposure in CT. We investigated the behavior of AEC systems in whole-body PET/CT. CT images of a whole-body phantom were acquired using AEC on two scanners from different manufactures. The effects of scout imaging direction and arm positioning on dose modulation were evaluated. Image noise was assessed in the chest and upper abdomen. On one scanner, AEC using two scout images in the posteroanterior (PA) and lateral (Lat) directions provided relatively constant image noise along the z-axis with the arms at the sides...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755847/-18-f-fdg-pet-ct-findings-in-hepatosplenic-gamma-delta-t-cell-lymphoma-case-reports-and-review-of-the-literature
#8
Michael W Cho, Bennett B Chin
Hepatosplenic Gamma Delta T cell lymphoma (γδHSTL) is a rare, highly aggressive, and rapidly lethal T cell lymphoma which manifests 18 F-FDG PET/CT findings that can mimic benign conditions. Patients with γδHSTL present with unexplained symptoms of a hematologic malignancy like the B symptoms of lymphoma including weight loss, fevers, and night sweats, as well as, splenomegaly and hepatomegaly. Thrombocytopenia, anemia, or neutropenia are also common due to spleen, liver and bone marrow involvement. The peripheral blood, however, typically does not show abnormal T cells...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755846/repeatability-of-fdg-pet-ct-metrics-assessed-in-free-breathing-and-deep-inspiration-breath-hold-in-lung-cancer-patients
#9
Lotte Nygård, Marianne C Aznar, Barbara M Fischer, Gitte F Persson, Charlotte B Christensen, Flemming L Andersen, Mirjana Josipovic, Seppo W Langer, Andreas Kjær, Ivan R Vogelius, Søren M Bentzen
We measured the repeatability of FDG PET/CT uptake metrics when acquiring scans in free breathing (FB) conditions compared with deep inspiration breath hold (DIBH) for locally advanced lung cancer. Twenty patients were enrolled in this prospective study. Two FDG PET/CT scans per patient were conducted few days apart and in two breathing conditions (FB and DIBH). This resulted in four scans per patient. Up to four FDG PET avid lesions per patient were contoured. The following FDG metrics were measured in all lesions and in all four scans: Standardized uptake value (SUV)peak , SUVmax , SUVmean , metabolic tumor volume (MTV) and total lesion glycolysis (TLG), based on an isocontur of 50% of SUVmax ...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755845/determination-of-binding-affinity-of-molecular-imaging-agents-for-steroid-hormone-receptors-in-breast-cancer
#10
Kelley Salem, Manoj Kumar, Kyle C Kloepping, Ciara J Michel, Yongjun Yan, Amy M Fowler
16α-[18 F]Fluoro-17β-estradiol ([18 F]FES) and 21-[18 F]-Fluoro-16α,17α-[(R)-(1'-α-furylmethylidene)dioxyl]-19-norpregn-4-ene-3,20-dione ([18 F]FFNP) are being investigated as imaging biomarkers for breast cancer patients. Quantitative positron emission tomography (PET) reflects both total receptor content and binding affinity. To study factors that may alter radiopharmaceutical binding and impact PET accuracy, assays that can separate receptor amount from binding affinity are needed. The study purpose was to quantify the binding parameters of [18 F]FES and [18 F]FFNP in breast cancer...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755844/standard-osem-vs-regularized-pet-image-reconstruction-qualitative-and-quantitative-comparison-using-phantom-data-and-various-clinical-radiopharmaceuticals
#11
Judit Lantos, Erik S Mittra, Craig S Levin, Andrei Iagaru
We investigated the block sequential regularized expectation maximization (BSREM) algorithm. ACR phantom measurements with different count statistics and 60 PET/CT research scans from the GE Discovery 600 and 690 scanners were reconstructed using BSREM and the standard-of-care OSEM algorithm. Hot concentration recovery and cold contrast recovery were measured from the phantom data. Two experienced nuclear medicine physicians reviewed the clinical images blindly. Liver SNR liver and SUVmax of the smallest lesion detected in each patient were also measured...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755843/fdg-pet-ct-suvmax-and-iaslc-ats-ers-histologic-classification-a-new-profile-of-lung-adenocarcinoma-with-prognostic-value
#12
Marina Suárez-Piñera, José Belda-Sanchis, Alvaro Taus, Albert Sánchez-Font, Antoni Mestre-Fusco, Marcel Jiménez, Lara Pijuan
Quantitative analysis of glucose consumption measured by maximum standardized uptake value (SUVmax) in lung adenocarcinoma (LA) remains in discussion and metabolic information provided by FDG-PET is not included in cancer staging. The first aim of this work was to evaluate the correlation between SUVmax and different histologic subtypes of LA. The second aim was to establish the correlation between SUVmax and TNM, genetic mutations and prognostic. Glucose consumption of primary tumor was quantified using SUVmax in 112 patients with histologically-confirmed LA...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755842/lipopolysaccharide-endotoxemia-induces-amyloid-%C3%AE-and-p-tau-formation-in-the-rat-brain
#13
Li-Ming Wang, Qi Wu, Ryan A Kirk, Kevin P Horn, Ahmed H Ebada Salem, John M Hoffman, Jeffrey T Yap, Joshua A Sonnen, Rheal A Towner, Fernando A Bozza, Rosana S Rodrigues, Kathryn A Morton
Amyloid beta (Aβ) plaques are not specific to Alzheimer's disease and occur with aging and neurodegenerative disorders. Soluble brain Aβ may be neuroprotective and increases in response to neuroinflammation. Sepsis is associated with neurocognitive compromise. The objective was to determine, in a rat endotoxemia model of sepsis, whether neuroinflammation and soluble Aβ production are associated with Aβ plaque and hyperphosphorylated tau deposition in the brain. Male Sprague Dawley rats received a single intraperitoneal injection of 10 mg/kg of lipopolysaccharide endotoxin (LPS)...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755841/quantitative-pet-of-liver-functions
#14
REVIEW
Susanne Keiding, Michael Sørensen, Kim Frisch, Lars C Gormsen, Ole Lajord Munk
Improved understanding of liver physiology and pathophysiology is urgently needed to assist the choice of new and upcoming therapeutic modalities for patients with liver diseases. In this review, we focus on functional PET of the liver: 1) Dynamic PET with 2-deoxy-2-[18 F]fluoro- D -galactose (18 F-FDGal) provides quantitative images of the hepatic metabolic clearance K met (mL blood/min/mL liver tissue) of regional and whole-liver hepatic metabolic function. Standard-uptake-value ( SUV ) from a static liver 18 F-FDGal PET/CT scan can replace K met and is currently used clinically...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29531863/open-letter-to-journal-editors-on-international-consensus-radiochemistry-nomenclature-guidelines
#15
Heinz H Coenen, Antony D Gee, Michael Adam, Gunnar Antoni, Cathy S Cutler, Yasuhisa Fujibayashi, Jae Min Jeong, Robert H Mach, Thomas L Mindt, Victor W Pike, Albert D Windhorst
No abstract text is available yet for this article.
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29531862/diagnostic-performance-of-pet-mr-in-the-evaluation-of-active-inflammation-in-crohn-disease
#16
Onofrio Antonio Catalano, Vincent Wu, Umar Mahmood, Alberto Signore, Mark Vangel, Andrea Soricelli, Marco Salvatore, Debra Gervais, Bruce R Rosen
This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Specificity for active inflammation was 74% for PET, 87% for MR, and 93% for PET/MR. Diagnostic accuracy was 84% for PET, 83% for MR, and 91% for PET/MR. In conclusion, PET/MR is significantly more accurate than either sub-modality alone and more specific than PET alone in the detection of active inflammation in patients with Crohn disease...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29531861/assessment-of-very-early-response-evaluation-with-18-f-fdg-pet-ct-predicts-survival-in-erlotinib-treated-nsclc-patients-a-comparison-of-methods
#17
Joan Fledelius, Anne Winther-Larsen, Azza A Khalil, Karin Hjorthaug, Jørgen Frøkiær, Peter Meldgaard
We evaluated whether changes in 18 F-Fluoro-D-Glucose (18 F-FDG)-uptake evaluated early during erlotinib treatment predict survival in non-small cell lung cancer (NSCLC) patients. Positron emission tomography (PET)/CT scans from 56 NSCLC patients before and after 7-10 days of erlotinib treatment were analyzed with four different methods: Visual evaluation and percentage change in lean body mass corrected standardized uptake values (SULs): SULpeak , SULmax and total lesion glycolysis (TLG). The semi-quantitative parameters abilities to predict progression free survival (PFS) and overall survival (OS) were compared and we found that percentage change in SULpeak , SULmax and TLG all correlated with PFS and OS with the strongest correlation found for TLG (R=0...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29531860/thalamic-and-basal-ganglia-metabolism-on-interictal-18-f-fdg-pet-in-temporal-lobe-epilepsy-an-suv-based-analysis
#18
Aditya Jain, Aaron F Struck, Kaitlin M Woo, Christine J Jaskowiak, Lance T Hall
The aim of this study was to investigate thalamic and basal ganglia (BG) metabolism in temporal lobe epilepsy (TLE) on interictal 18 F-FDG PET using standardized uptake value (SUV). Retrospective review of data was undertaken for patients who were surgically treated for medically intractable TLE. All patients underwent 18 F-FDG PET, MRI brain and EEG as preoperative workup, and subsequently underwent temporal lobe resection. Postoperative outcomes were analyzed as without or with residual disabling seizures...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29531859/synthesis-radiolabelling-and-evaluation-of-11-c-pb212-as-a-radioligand-for-imaging-sigma-1-receptors-using-pet
#19
Francesco Spinelli, Ahmed Haider, Annamaria Toscano, Maria Laura Pati, Claudia Keller, Francesco Berardi, Nicola Antonio Colabufo, Carmen Abate, Simon M Ametamey
The Sigma-1 receptor (Sig-1R) has been described as a pluripotent modulator of distinct physiological functions and its involvement in various central and peripheral pathological disorders has been demonstrated. However, further investigations are required to understand the complex role of the Sig-1R as a molecular chaperon. A specific PET radioligand would provide a powerful tool in Sig-1R related studies. As part of our efforts to develop a Sig-1R PET radioligand that shows antagonistic properties, we investigated the suitability of 1-(4-(6-methoxynaphthalen-1-yl)butyl)-4-methylpiperidine (designated PB212) for imaging Sig-1R...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29531858/preparation-and-evaluation-of-a-68-ga-labeled-rgd-containing-octapeptide-for-noninvasive-imaging-of-angiogenesis-biodistribution-in-non-human-primate
#20
Irina Velikyan, Örjan Lindhe
Monitoring general disease marker such as angiogenesis may contribute to the development of personalized medicine and improve therapy outcome. Readily availability of positron emitter based imaging agents providing quantification would expand clinical positron emission tomography (PET) applications. Generator produced 68 Ga provides PET images of high resolution and the half-life time frame is compatible with the pharmacokinetics of small peptides comprising arginine-glycine-aspartic acid (RGD) sequence specific to αv β3 integrin receptors...
2018: American Journal of Nuclear Medicine and Molecular Imaging
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