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American Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/29348983/sparse-domain-approaches-in-dynamic-spect-imaging-with-high-performance-computing
#1
Hui Pan, Haoran Chang, Debasis Mitra, Grant T Gullberg, Youngho Seo
Iterative reconstruction algorithms often have relatively large computation time affecting their clinical deployment. This is especially true for 4D reconstruction in dynamic imaging (DI). In this work, we have shown how sparse domain approaches and parallelization for static 3D image reconstruction and 4D dynamic image reconstruction (directly from sinogram) in Single Photon Emission Computed Tomography (SPECT), without any intermediate 3D reconstructions, can improve computational efficiency. DI in SPECT is one of the hardest inverse problems in medical image reconstruction area and slow reconstruction is a challenge for this promising protocol...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29348982/pictorial-atlas-of-symptomatic-accessory-ossicles-by-18f-sodium-fluoride-naf-pet-ct
#2
Sharjeel Usmani, Cherry Sit, Gopinath Gnanasegaran, Tim Van den Wyngaert, Fahad Marafi
Accessory ossicles are developmental variants which are often asymptomatic. When incidentally picked up on imaging, they are often inconsequential and rarely a cause for concern. However, they may cause pain or discomfort due to trauma, altered stress, and over-activity. Nuclear scintigraphy may play a role in the diagnosis and localizing pain generators. 18F-Sodium Fluoride (NaF) is a PET imaging agent used in bone imaging. Although commonly used in imaging patients with cancer imaging malignancy, 18F-NaF may be useful in the evaluation of benign bone and joint conditions...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29348981/development-of-a-clinically-feasible-11c-pe2i-pet-method-for-differential-diagnosis-of-parkinsonism-using-reduced-scan-duration-and-automated-reference-region-extraction
#3
My Jonasson, Lieuwe Appel, Torsten Danfors, Dag Nyholm, Håkan Askmark, Andreas Frick, Jonas Engman, Tomas Furmark, Jens Sörensen, Mark Lubberink
[11C]PE2I is a highly selective dopamine transporter PET ligand. Parametric images based on dynamic [11C]PE2I scans, showing dopamine transporter availability (BPND) and relative cerebral blood flow (R1), can be used in differential diagnosis of parkinsonism. This work aimed to investigate a shortened scan duration and automated generation of parametric images which are two prerequisites for routine clinical application. Twelve subjects with parkinsonism and seventeen healthy controls underwent 80 min dynamic [11C]PE2I PET scans...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29348980/the-value-of-fdg-pet-ct-for-follow-up-of-patients-with-melanoma-a-retrospective-analysis
#4
Philip H Vensby, Grethe Schmidt, Andreas Kjær, Barbara M Fischer
The incidence of melanoma (MM) is among the fastest rising cancers in the western countries. Positron Emission Tomography with Computed Tomography (PET/CT) is a valuable non-invasive tool for the diagnosis and staging of patients with MM. However, research on the value of PET/CT in follow-up of melanoma patients is limited. This study assesses the diagnostic value of PET/CT for follow-up after melanoma surgery. This retrospective study includes patients with MM who performed at least one PET/CT scan after initial surgery and staging...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29348979/simplified-estimation-of-binding-parameters-based-on-image-derived-reference-tissue-models-for-dopamine-transporter-bindings-in-non-human-primates-using-18f-fe-pe2i-and-pet
#5
Ikuo Odano, Andrea Varrone, Tetsuo Hosoya, Kazuya Sakaguchi, Balázs Gulyás, Parasuraman Padmanabhan, Krishna Kanta Ghosh, Chang-Tong Yang, Ilonka Guenther, Zhimin Wang, Raymond Serrano, Nevil Ghislain Chimon, Christer Halldin
The aim of this study on dopamine transporter binding by [18F]FE-PE2I and PET was to describe an image-derived approach using reference tissue models: the Logan DVR approach and simplified reference tissue model (SRTM), the features of which were simple to operate and precise in the measurements. Using the approach, the authors sought to obtain binding images and parameters. [18F]FE-PE2I and dynamic PET as well as an MRI was performed on three rhesus monkeys, and metabolite corrected arterial plasma inputs were obtained...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29181271/radium-223-in-metastatic-hormone-sensitive-high-grade-prostate-cancer-initial-experience
#6
García-Pérez Francisco Osvaldo, Medina-Ornelas Sevastián Salvador, Santana-Ríos Zael, Sobrevilla-Moreno Nora
Our study evaluates the feasibility of compassionate exemption of Radium-223 (223Ra) treatment in metastatic hormone-sensitive high-grade prostate cancer (mHSHGPC) patients with concomitant androgen deprivation-therapy (ADT). Seven patients with mHSHGPC, were treated with six cycles of 223Ra plus ADT. All patients had undergone to 18F-NaF-PET/CT. A qualitative analyses of the 18F-NaF-PET/CT was performed in conjunction with Alkaline Phosphatase (ALP), Lactate-dehydrogenase (LDH) and Prostatic-Specific Antigen (PSA) values...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29181270/safety-and-accuracy-of-68ga-dotatoc-pet-ct-in-children-and-young-adults-with-solid-tumors
#7
Chenue Abongwa, Sarah Mott, Blanca Schafer, Parren McNeely, Ghada Abusin, Thomas O'Dorisio, Gideon Zamba, M Sue O'Dorisio, Yusuf Menda
68Ga-DOTA-tyr3-Octreotide (68Ga-DOTATOC) PET/CT has been shown to have high accuracy in adults with neuroendocrine tumors, however has not been studied in pediatric patients. This study evaluated the safety and accuracy of 68Ga-DOTATOC PET/CT in children and young adults with solid tumors that express somatostatin receptor type 2. A series of three prospective, IRB approved, clinical trials evaluating safety and efficacy of 68Ga-DOTATOC PET/CT were conducted for subjects aged 6 months to 90 years. This study reports the results for the 26 children and young adults, aged 16 months to 29 years who participated in these trials...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29181269/diagnostic-test-accuracy-study-of-18f-sodium-fluoride-pet-ct-99mtc-labelled-diphosphonate-spect-ct-and-planar-bone-scintigraphy-for-diagnosis-of-bone-metastases-in-newly-diagnosed-high-risk-prostate-cancer
#8
Randi F Fonager, Helle D Zacho, Niels C Langkilde, Joan Fledelius, June A Ejlersen, Christian Haarmark, Helle W Hendel, Mine Benedicte Lange, Mads R Jochumsen, Jesper C Mortensen, Lars J Petersen
The aim of this study was to prospectively compare planar, bone scan (BS) versus SPECT/CT and NaF PET/CT in detecting bone metastases in prostate cancer. Thirty-seven consecutive, newly diagnosed, prostate cancer patients with prostate specific antigen (PSA) levels ≥ 50 ng/mL and who were considered eligible for androgen-deprivation therapy (ADT) were included in this study. BS, SPECT/CT, and NaF PET/CT, were performed prior to treatment and were repeated after six months of ADT. Baseline images from each index test were independently read by two experienced readers...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29181268/the-flip-flop-fungus-sign-an-fdg-pet-ct-sign-of-benignity
#9
Alex A Nagelschneider, Stephen M Broski, William P Holland, David E Midthun, Anne-Marie Sykes, Val J Lowe, Patrick J Peller, Geoffrey B Johnson
Benign granulomatous processes such as fungal infection may mimic metastatic lung cancer on FDG PET/CT. We found that these processes often have draining lymph node(s) with equal or greater FDG activity than associated lung nodule(s), a "flip-flop" of what is commonly seen in lung cancer. The aim of this study was to examine the utility of this "flip-flop fungus" (FFF) sign for diagnosing benign pulmonary disease. FDG PET/CT scans performed between 9/09-3/13 for the indications of pulmonary nodule or mass were reviewed...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29181267/variation-and-repeatability-of-measured-standardized-uptake-values-depending-on-actual-values-a-phantom-study
#10
Tomohiro Kaneta, Na Sun, Matsuyoshi Ogawa, Hitoshi Iizuka, Tetsu Arisawa, Ayako Hino-Shishikura, Keisuke Yoshida, Tomio Inoue
Standardized uptake values (SUVs) are the most widely used quantitative imaging biomarkers in positron emission tomography (PET); however, little is known about the changes in variation and repeatability of SUVs depending on the magnitude of the values. We hypothesized that low SUVs have larger variations than high SUVs, and attempted various kinds of experimental PET scans using a phantom. By adjusting the ratio of F-18 solution to tap water, a NEMA IEC body phantom was set for SUVs of 2.0, 4.0, and 8.0 inside six hot spheres...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28913158/dosimetry-and-first-human-experience-with-89-zr-panitumumab
#11
Liza Lindenberg, Stephen Adler, Ismail B Turkbey, Francesca Mertan, Anita Ton, Khanh Do, Shivaani Kummar, Esther Mena Gonzalez, Sibaprasad Bhattacharyya, Paula M Jacobs, Peter Choyke
(89)Zr-panitumumab is a novel immuno-PET radiotracer. A fully humanized IgG2 antibody, panitumumab binds with high affinity to the extracellular ligand binding domain of EGFR. Immuno-PET with radiolabeled panitumumab is a non-invasive method that could characterize EGFR expression in tumors and metastatic lesions. It might also assist in selecting patients likely to benefit from targeted therapy as well as monitor response and drug biodistribution for dosing guidance. Our objective was to calculate the maximum dosing for effective imaging with minimal radiation exposure in a small subset...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28913157/non-functioning-gastroenteropancreatic-gep-tumors-a-111-in-pentetreotide-spect-ct-diagnostic-study
#12
Angela Spanu, Orazio Schillaci, Bastiana Piras, Diego F Calvisi, Antonio Falchi, Roberta Danieli, Susanna Nuvoli, Franca Dore, Giuseppe Madeddu
In a retrospective study performed in non-functioning GEP tumor patients we further investigated (111)In-Pentetreotide SPECT/CT usefulness in diagnosis, staging and follow-up also evaluating whether the procedure may give more information than conventional imaging procedures (CIP), such as CT, MRI, US. We enrolled 104 consecutive patients with non-functioning GEP tumors, 30 in initial diagnosis and staging phases (IDS) and 74 in follow-up (FU). All patients underwent somatostatin receptor scintigraphy (SRS) whole body scan at 4, 24 and, if necessary, 48 hours followed by abdominal and chest SPECT/CT after (111)In-Pentetreotide 148-222 MBq i...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28913156/head-and-neck-pet-ct-therapy-response-interpretation-criteria-hopkins-criteria-external-validation-study
#13
Ayse Tuba Kendi, David Brandon, Jeffrey Switchenko, Jeffery Trad Wadsworth, Mark W El-Deiry, Nabil F Saba, David M Schuster, Rathan M Subramaniam
Qualitative assessment of PET/CT results in post therapy is very important to provide a reproducible and systemic reporting. A recently introduced response criteria, known as the Hopkins criteria showed promising results. Our aim is to externally validate the Hopkins interpretation system to assess therapy response in head and neck squamous cell cancer (HNSCC). The study included 69 biopsy proven HNSCC patients who underwent post therapy PET/CT between 5-24 weeks after completion of therapy. PET/CT images were interpreted by one nuclear medicine physician and one nuclear radiologist, independently...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28913155/hepatic-metabolism-of-11-c-methionine-and-secretion-of-11-c-protein-measured-by-pet-in-pigs
#14
Jacob Horsager, Susanne Bach Lausten, Dirk Bender, Ole Lajord Munk, Susanne Keiding
Hepatic amino acid metabolism and protein secretion are essential liver functions that may be altered during metabolic stress, e.g. after surgery. We wished to develop a dynamic liver PET method using the radiolabeled amino acid (11)C-methionine to examine this question. Eleven 40-kg pigs were allocated to either laparotomy or pneumoperitoneum. 24 hours after surgery a 70-min dynamic PET scanning of the liver with arterial blood sampling was performed immediately after intravenous injection of (11)C-methionine...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28913154/pet-ct-imaging-of-the-diapeutic-alkylphosphocholine-analog-124-i-clr1404-in-high-and-low-grade-brain-tumors
#15
Lance T Hall, Benjamin Titz, H Ian Robins, Bryan P Bednarz, Scott B Perlman, Jamey P Weichert, John S Kuo
CLR1404 is a cancer-selective alkyl phosphocholine (APC) analog that can be radiolabeled with (124)I for PET imaging, (131)I for targeted radiotherapy and/or SPECT imaging, or (125)I for targeted radiotherapy. Studies have demonstrated avid CLR1404 uptake and prolonged retention in a broad spectrum of preclinical tumor models. The purpose of this pilot trial was to demonstrate avidity of (124)I-CLR1404 in human brain tumors and develop a framework to evaluate this uptake for use in larger studies. 12 patients (8 men and 4 women; mean age of 43...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28913153/quantitative-analysis-of-18-f-naf-dynamic-pet-ct-cannot-differentiate-malignant-from-benign-lesions-in-multiple-myeloma
#16
Christos Sachpekidis, Jens Hillengass, Hartmut Goldschmidt, Hoda Anwar, Uwe Haberkorn, Antonia Dimitrakopoulou-Strauss
A renewed interest has been recently developed for the highly sensitive bone-seeking radiopharmaceutical (18)F-NaF. Aim of the present study is to evaluate the potential utility of quantitative analysis of (18)F-NaF dynamic PET/CT data in differentiating malignant from benign degenerative lesions in multiple myeloma (MM). 80 MM patients underwent whole-body PET/CT and dynamic PET/CT scanning of the pelvis with (18)F-NaF. PET/CT data evaluation was based on visual (qualitative) assessment, semi-quantitative (SUV) calculations, and absolute quantitative estimations after application of a 2-tissue compartment model and a non-compartmental approach leading to the extraction of fractal dimension (FD)...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28721307/multispectral-fluorescence-guided-surgery-a-feasibility-study-in-a-phantom-using-a-clinical-grade-laparoscopic-camera-system
#17
Danny M van Willigen, Nynke S van den Berg, Tessa Buckle, Gijs H KleinJan, James C Hardwick, Henk G van der Poel, Fijs Wb van Leeuwen
Although the possibilities in image guided surgery are advancing rapidly, complex surgical procedures such as nerve sparing prostatectomy still lack precision regarding differentiation between diseased and delicate anatomical structures. Here, the use of complementary fluorescent tracers in combination with a dedicated multispectral fluorescence camera system could support differentiation between healthy and diseased tissue. In this study, we provide proof of concept data indicating how a modified clinical-grade fluorescence laparoscope can be used to sensitively detect white light and three fluorescent dyes (fluorescein, Cy5, and ICG) in a sequential fashion...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28721306/role-of-conventional-magnetic-resonance-imaging-in-the-screening-of-epilepsy-with-structural-abnormalities-a-pictorial-essay
#18
REVIEW
Xu Zhao, Zhiqiang Zhou, Wenzhen Zhu, Hongbing Xiang
Epilepsy is a chronic neurological disease with serious impact on patients and society. The causes of epilepsy comprise a heterogeneous group of disorders, rendering epilepsy diagnoses rather difficult and challenging. The primary role of MRI is to locate and define the probable anatomic epileptogenic lesions. In the developing countries, where functional MRI (fMRI) is not popular, conventional MRI (cMRI) becomes especially important in epilepsy diagnoses. Apart from that, an experienced radiologist can increase the diagnostic yield of MRI to epileptogenic lesions...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28721305/fully-automated-gmp-production-of-68-ga-ga-do3a-vs-cys-40-exendin-4-for-clinical-use
#19
Irina Velikyan, Ulrika Rosenstrom, Olof Eriksson
[(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4/PET-CT targeting glucagon like peptide-1 receptor (GLP-1R) has previously demonstrated its potential clinical value for the detection of insulinomas. The production and accessibility of this radiopharmaceutical is one of the critical factors in realization of clinical trials and routine clinical examinations. Previously, the radiopharmaceutical was prepared manually, however larger scale of clinical trials and healthcare requires automation of the production process in order to limit the operator radiation dose as well as improve tracer manufacturing robustness and on-line documentation for enhanced good manufacturing practice (GMP) compliance...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28721304/imaging-features-of-paget-s-disease-on-11-c-choline-pet-ct
#20
Cameron E Leitch, Ajit H Goenka, Benjamin M Howe, Stephen M Broski
The purpose of this study was to investigate the appearance of Paget's disease (PD) on (11)C choline PET/CT and correlate these findings to serum alkaline phosphatase (ALP) level and skeletal scintigraphy. With IRB approval, our institutional (11)C choline PET/CT database (9/2005-6/2015) was searched for patients with PD. Site of osseous involvement, CT appearance, and multiple semi-quantitative measures were measured and correlated with ALP and degree of uptake on bone scan. Our search identified 10 males (mean age 79...
2017: American Journal of Nuclear Medicine and Molecular Imaging
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