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American Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/28533939/efficacy-of-peptide-receptor-radionuclide-therapy-with-177-lu-octreotate-in-metastatic-pulmonary-neuroendocrine-tumors-a-dual-centre-analysis
#1
Amir Sabet, Alexander R Haug, Collin Eiden, Christoph J Auernhammer, Birgit Simon, Peter Bartenstein, Hans J Biersack, Samer Ezziddin
There is lack of data on the specific benefit of peptide receptor radionuclide therapy (PRRT) in neuroendocrine tumors (NET) of pulmonary origin. This dual- centre study aimed to assess outcome and toxicity of standardized PRRT with (177)Lu-octreotate in a patient population of advanced pulmonary NET of grade 1-2. We retrospectively assessed 22 consecutively patients treated with 4 intended cycles at 3 monthly intervals (mean activity per cycle 7.8±0.68 GBq). In a median follow-up period of 54 months, no significant nephrotoxicity (≥ grade 3) was observed...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28533938/radionuclide-bone-scan-spect-ct-lowering-the-dose-of-ct-significantly-reduces-radiation-dose-without-impacting-ct-image-quality
#2
Sandeep Kumar Gupta, Scott Trethewey, Bree Brooker, Natalie Rutherford, Jenny Diffey, Suresh Viswanathan, John Attia
The CT component of SPECT-CT is required for attenuation correction and anatomical localization of the uptake on SPECT but there is no guideline about the optimal CT acquisition parameters. In our department, a standard CT acquisition protocol was changed in 2013 to give lower radiation dose to the patient. In this study, we retrospectively compared the effects on patient dose as well as the CT image quality with current versus older CT protocols. Ninety nine consecutive patients [n=51 Standard dose 'old' protocol (SDP); n=48 lower dose 'new' protocol (LDP)] with lumbar spine SPECT-CT for bone scan were examined...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28533937/a-phase-one-single-dose-open-label-clinical-safety-and-pet-mr-imaging-study-of-68-ga-dotatoc-in-healthy-volunteers
#3
Shadi A Esfahani, Stephanie Salcedo, Pedram Heidari, Onofrio A Catalano, Rachel Pauplis, Jacob Hesterman, James F Kronauge, Umar Mahmood
This prospective pilot study provides a dynamic whole body PET/MR image database, clinical safety, biodistribution profile and dosimetry of (68)Ga-DOTATOC in healthy subjects, to establish a baseline and standard reference for its use in diagnosis and treatment response evaluation among patients with somatostatin receptor expressing neoplastic diseases. Dynamic whole body PET/MR imaging was performed in 12 healthy subjects (male/female: 8/4) after injection of 242.39 ± 53.38 MBq (mean ± SD) (68)Ga-DOTATOC...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28533936/synthesis-and-evaluation-of-64-cu-psma-617-targeted-for-prostate-specific-membrane-antigen-in-prostate-cancer
#4
Can Cui, Masayuki Hanyu, Akiko Hatori, Yiding Zhang, Lin Xie, Tomoya Ohya, Masami Fukada, Hisashi Suzuki, Kotaro Nagatsu, Cuiping Jiang, Rui Luo, Guoqiang Shao, Mingrong Zhang, Feng Wang
We radiolabeled a ligand, PSMA-617, of prostate-specific membrane antigen (PSMA) with copper-64 ((64)Cu), to evaluate the metabolism, biodistribution, and potential of [(64)Cu]PSMA-617 for PET imaging of prostate cancer. [(64)Cu]PSMA-617 was synthesized by heating PSMA-617 with [(64)Cu]CuCl2 in buffer solution at 90°C for 5 min. In vitro uptake was determined in two cell lines of prostate cancer. In vivo regional distributions were determined in normal and tumor-bearing mice. High radiolabeling efficiency of (64)Cu for PSMA-617 yielded [(64)Cu]PSMA-617 with >99% radiochemical purity...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28123866/-64-cucl2-pet-ct-imaging-of-mouse-muscular-injury-induced-by-electroporation
#5
Fang Xie, Huawei Cai, Fangyu Peng
Skeletal muscle injury is common in body injuries suffered in sports and car accidents. Development of new tracers is significant for assessing muscular injury with positron emission tomography/computed tomography (PET/CT) and monitoring repair of muscle injury in response to treatment. Copper is required for wound healing and increased copper ions were detected in the soft tissue of wound in rodents and human. Based on the recent finding of increased (64)Cu uptake in the traumatic brain injury, this study aimed to explore use of (64)CuCl2 as a radiotracer for molecular imaging of muscular injury using PET/CT...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28123865/automated-quantitation-of-cold-inducible-human-brown-adipose-tissue-with-fdg-pet-ct-with-application-to-fibromyalgia
#6
José V Pardo, Joel T Lee, Robert C Larson, Paul Thuras, Alice A Larson
Increasing recognition of the importance of brown adipose tissue (BAT) motivates the development of reproducible and quantitative methods for measuring it. Positron emission tomography (PET)/computerized tomography (CT) with (18)F-fluorodeoxyglucose (FDG) has become the principal method to non-invasively detect brown adipose tissue (BAT) in humans. Improvements in quantitation and standardization will drive further clinical application. One disorder hypothesized to involve dysregulation in thermoregulation and the processing of pain involving BAT is fibromyalgia syndrome (FMS)...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28123864/diagnostic-performance-of-an-automated-analysis-software-for-the-diagnosis-of-alzheimer-s-dementia-with-18-f-fdg-pet
#7
Sasan Partovi, Roger Yuh, Sara Pirozzi, Ziang Lu, Spencer Couturier, Ulrich Grosse, Mark D Schluchter, Aaron Nelson, Robert Jones, James K O'Donnell, Peter Faulhaber
The objective of this study was to assess the ability of a quantitative software-aided approach to improve the diagnostic accuracy of (18)F FDG PET for Alzheimer's dementia over visual analysis alone. Twenty normal subjects (M:F-12:8; mean age 80.6 years) and twenty mild AD subjects (M:F-12:8; mean age 70.6 years) with (18)F FDG PET scans were obtained from the ADNI database. Three blinded readers interpreted these PET images first using a visual qualitative approach and then using a quantitative software-aided approach...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28123863/performance-characteristics-and-relationship-of-psa-value-kinetics-on-carbon-11-acetate-pet-ct-imaging-in-biochemical-relapse-of-prostate-cancer
#8
Fabio D Almeida, Chi-Kwan Yen, Mark C Scholz, Richard Y Lam, Jeffrey Turner, Larry L Bans, Robert Lipson
An elevated serum prostate-specific antigen (PSA) level alone cannot distinguish between local-regional recurrences and distant metastases after treatment with curative intent. With available salvage treatments, it has become important to localize the site of recurrence. (11)C-Acetate PET/CT was performed in patients with rising PSA, with statistical analysis of detection rates, sites/location of detection, PSA kinetics and comparison with other tracers (FDG and Choline). Correlation to biopsy, subsequent imaging and PSA response to focal treatment was also performed...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28078184/precision-medicine-and-molecular-imaging-new-targeted-approaches-toward-cancer-therapeutic-and-diagnosis
#9
Mojtaba Ghasemi, Iraj Nabipour, Abdolmajid Omrani, Zeinab Alipour, Majid Assadi
This paper presents a review of the importance and role of precision medicine and molecular imaging technologies in cancer diagnosis with therapeutics and diagnostics purposes. Precision medicine is progressively becoming a hot topic in all disciplines related to biomedical investigation and has the capacity to become the paradigm for clinical practice. The future of medicine lies in early diagnosis and individually appropriate treatments, a concept that has been named precision medicine, i.e. delivering the right treatment to the right patient at the right time...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28078183/absorbed-radiation-dosimetry-of-the-d3-specific-pet-radioligand-18-f-fluortriopride-estimated-using-rodent-and-nonhuman-primate
#10
Richard Laforest, Morvarid Karimi, Stephen M Moerlein, Jinbin Xu, Hubert P Flores, Christopher Bognar, Aixiao Li, Robert H Mach, Joel S Perlmutter, Zhude Tu
[(18)F]FluorTriopride ([(18)F]FTP) is a dopamine D3-receptor preferring radioligand with potential for investigation of neuropsychiatric disorders including Parkinson disease, dystonia and schizophrenia. Here we estimate human radiation dosimetry for [(18)F]FTP based on the ex-vivo biodistribution in rodents and in vivo distribution in nonhuman primates. Biodistribution data were generated using male and female Sprague-Dawley rats injected with ~370 KBq of [(18)F]FTP and euthanized at 5, 30, 60, 120, and 240 min...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28078182/utility-of-11-c-methionine-and-11-c-donepezil-for-imaging-of-staphylococcus-aureus-induced-osteomyelitis-in-a-juvenile-porcine-model-comparison-to-autologous-111-in-labelled-leukocytes-99m-tc-dpd-and-18-f-fdg
#11
Pia Afzelius, Aage Ko Alstrup, Henrik C Schønheyder, Per Borghammer, Svend B Jensen, Dirk Bender, Ole L Nielsen
The aim of this study was to compare (11)C-methionine and (11)C-donepezil positron emission tomography (PET) with (111)In-labeled leukocyte and (99m) Tc-DPD (Tc-99m 3,3-diphosphono-1,2-propanedicarboxylic acid) single-photon emission computed tomography (SPECT), and (18)F-fluorodeoxyglucose ((18)F-FDG) PET to improve detection of osteomyelitis. The tracers' diagnostic utility where tested in a juvenile porcine hematogenously induced osteomyelitis model comparable to osteomyelitis in children. Five 8-9 weeks old female domestic pigs were scanned seven days after intra-arterial inoculation in the right femoral artery with a porcine strain of Staphylococcus aureus...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27766186/prediction-of-positron-emission-tomography-computed-tomography-pet-ct-positivity-in-patients-with-high-risk-primary-melanoma
#12
Maria Danielsen, Andreas Kjaer, Max Wu, Lea Martineau, Mehdi Nosrati, Stanley Pl Leong, Richard W Sagebiel, James R Miller Iii, Mohammed Kashani-Sabet
Positron emission tomography/computed tomography (PET/CT) is an important tool to identify occult melanoma metastasis. To date, it is controversial which patients with primary cutaneous melanoma should have staging PET/CT. In this retrospective analysis of more than 800 consecutive patients with cutaneous melanoma, we sought to identify factors predictive of PET/CT positivity in the setting of newly-diagnosed high-risk primary melanoma to determine those patients most appropriate to undergo a PET/CT scan as part of their diagnostic work up...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27766185/validation-of-true-low-dose-18-f-fdg-pet-of-the-brain
#13
David Fällmar, Johan Lilja, Lena Kilander, Torsten Danfors, Mark Lubberink, Elna-Marie Larsson, Jens Sörensen
The dosage of (18)F-FDG must be sufficient to ensure adequate PET image quality. For younger patients and research controls, the lowest possible radiation dose should be used. The purpose of this study was to find a protocol for FDG-PET of the brain with reduced radiation dose and preserved quantitative characteristics. Eight patients with neurodegenerative disorders and nine controls (n=17) underwent FDG-PET/CT twice on separate occasions, first with normal-dose (3 MBq/kg), and second with low-dose (0.75 MBq/kg, 25% of the original)...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27766184/suv-measurement-of-normal-vertebrae-using-spect-ct-with-tc-99m-methylene-diphosphonate
#14
Tomohiro Kaneta, Matsuyoshi Ogawa, Hiromitsu Daisaki, Shintaro Nawata, Keisuke Yoshida, Tomio Inoue
The purpose of this study is to perform quantitative measurement based on the standardized uptake value (SUV) of the uptake of Tc-99m methylene diphosphonate (MDP) in the normal vertebrae using a single photon emission tomography (SPECT)/computed tomography (CT) scanner. A retrospective study of patients with cancer or joint disorders was performed. We acquired data for a group of 29 patients (8 women and 21 men; mean age, 68.2 ± 6.7 years; age range, 44-87 years) undergoing bone SPECT/CT scans with Tc-99m MDP between September and October 2015...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27766183/genetic-engineered-molecular-imaging-probes-for-applications-in-cell-therapy-emphasis-on-mri-approach
#15
REVIEW
In K Cho, Silun Wang, Hui Mao, Anthony Ws Chan
Recent advances in stem cell-based regenerative medicine, cell replacement therapy, and genome editing technologies (i.e. CRISPR-Cas 9) have sparked great interest in in vivo cell monitoring. Molecular imaging promises a unique approach to noninvasively monitor cellular and molecular phenomena, including cell survival, migration, proliferation, and even differentiation at the whole organismal level. Several imaging modalities and strategies have been explored for monitoring cell grafts in vivo. We begin this review with an introduction describing the progress in stem cell technology, with a perspective toward cell replacement therapy...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27648374/feasibility-of-carotid-artery-pet-mri-in-psoriasis-patients
#16
Prabhakar Rajiah, Mojgan Hojjati, Ziang Lu, Vijaya Kosaraju, Sasan Partovi, James K O'Donnell, Christopher Longenecker, Grace A McComsey, Jackelyn B Golden, Fuad Muakkassa, Scott Santilli, Thomas S McCormick, Kevin D Cooper, Neil J Korman
We report our initial experience of performing integrated PET/MR imaging of the carotid arteries in psoriatic patients. Eleven patients with psoriasis and ten controls underwent carotid PET/MRI. Following injection of the FDG tracer, 3d T1w gradient echo sequence (atMR) was obtained for attenuation correction of PET data. High resolution images of carotid artery were then obtained, including pre-and post-contrast T1-w, T2-w and proton-density images as well as TOF images followed by PET imaging of the torso...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27648373/the-benefit-of-personalized-hybrid-spect-ct-pulmonary-imaging
#17
Milan Simanek, Pavel Koranda
Hybrid pulmonary imaging in the present day has seen a fusion of various uses of CT scans, including angiography (CTAG), diagnostic CT, low dose CT (LDCT), and perfusion or ventilation scintigraphy in tomographic or planar imaging. Determining the most effective individualized test for the complete diagnostics of patients with pulmonary symptoms for various groups of patients is a major issue. The aim of the present study was to assess the effectiveness of the implementation of hybrid imaging in current methods of nuclear medicine in differential diagnostics of pulmonary embolism (PE)...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27648372/pet-imaging-reveals-sex-differences-in-kappa-opioid-receptor-availability-in-humans-in-vivo
#18
Aishwarya Vijay, Shuo Wang, Patrick Worhunsky, Ming-Qiang Zheng, Nabeel Nabulsi, Jim Ropchan, Suchitra Krishnan-Sarin, Yiyun Huang, Evan D Morris
Opioid receptors may play critical roles in alcoholism and other addictions, addiction withdrawal, and depression and are considered pharmacological targets for treatment of these conditions. Sex differences have been demonstrated in mu (MOR) and delta (DOR) opioid receptors in humans, in vivo. In addition, sex differences have been observed in efficacy of treatment targeting kappa opioid receptors (KOR). Our goal in the present study was to compare the availability of KOR (1) between healthy control (HC) men and women...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27508106/development-of-a-novel-linearly-filled-derenzo-micropet-phantom
#19
Benjamin L Cox, Stephen A Graves, Mohammed Farhoud, Todd E Barnhart, Justin J Jeffery, Kevin W Eliceiri, Robert J Nickles
Positron emission tomography (PET) phantoms are used to calibrate PET scanners so that inter-scanner and inter-isotope comparison can be made between PET datasets. Hot rod style phantoms have a hole pattern, which is filled with a positron-emitting isotope and typically involves using two radioisotope reservoirs with the pattern created with channels in between. However, this configuration is difficult to fill and requires an excess of activity and volume. Here we present an alternative design, a phantom that is linearly filled-one channel at a time...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27508105/synthesis-and-pre-clinical-evaluation-of-an-18-f-labeled-single-chain-antibody-fragment-for-pet-imaging-of-epithelial-ovarian-cancer
#20
Sai Kiran Sharma, Melinda Wuest, Jenilee D Way, Vincent R Bouvet, Monica Wang, Frank R Wuest
Anti-CA125 antibodies have been used in immunoassays to quantify levels of shed antigen in the serum of patients who are under surveillance for epithelial ovarian cancer (EOC). However, there is currently no molecular imaging probe in the clinic for the assessment of CA125 expression in vivo. The present study describes the development of an (18)F-labeled single-chain variable fragment (scFv) for PET imaging of CA125 in preclinical EOC models. Anti-CA125 scFv was derived from MAb-B43.13 by recombinant expression of the fragment in E...
2016: American Journal of Nuclear Medicine and Molecular Imaging
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