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American Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/29755848/ct-dose-modulation-using-automatic-exposure-control-in-whole-body-pet-ct-effects-of-scout-imaging-direction-and-arm-positioning
#1
Yusuke Inoue, Kazunori Nagahara, Hiroko Kudo, Hiroyasu Itoh
Automatic exposure control (AEC) modulates tube current and consequently X-ray exposure in CT. We investigated the behavior of AEC systems in whole-body PET/CT. CT images of a whole-body phantom were acquired using AEC on two scanners from different manufactures. The effects of scout imaging direction and arm positioning on dose modulation were evaluated. Image noise was assessed in the chest and upper abdomen. On one scanner, AEC using two scout images in the posteroanterior (PA) and lateral (Lat) directions provided relatively constant image noise along the z-axis with the arms at the sides...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755847/-18-f-fdg-pet-ct-findings-in-hepatosplenic-gamma-delta-t-cell-lymphoma-case-reports-and-review-of-the-literature
#2
Michael W Cho, Bennett B Chin
Hepatosplenic Gamma Delta T cell lymphoma (γδHSTL) is a rare, highly aggressive, and rapidly lethal T cell lymphoma which manifests 18 F-FDG PET/CT findings that can mimic benign conditions. Patients with γδHSTL present with unexplained symptoms of a hematologic malignancy like the B symptoms of lymphoma including weight loss, fevers, and night sweats, as well as, splenomegaly and hepatomegaly. Thrombocytopenia, anemia, or neutropenia are also common due to spleen, liver and bone marrow involvement. The peripheral blood, however, typically does not show abnormal T cells...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755846/repeatability-of-fdg-pet-ct-metrics-assessed-in-free-breathing-and-deep-inspiration-breath-hold-in-lung-cancer-patients
#3
Lotte Nygård, Marianne C Aznar, Barbara M Fischer, Gitte F Persson, Charlotte B Christensen, Flemming L Andersen, Mirjana Josipovic, Seppo W Langer, Andreas Kjær, Ivan R Vogelius, Søren M Bentzen
We measured the repeatability of FDG PET/CT uptake metrics when acquiring scans in free breathing (FB) conditions compared with deep inspiration breath hold (DIBH) for locally advanced lung cancer. Twenty patients were enrolled in this prospective study. Two FDG PET/CT scans per patient were conducted few days apart and in two breathing conditions (FB and DIBH). This resulted in four scans per patient. Up to four FDG PET avid lesions per patient were contoured. The following FDG metrics were measured in all lesions and in all four scans: Standardized uptake value (SUV)peak , SUVmax , SUVmean , metabolic tumor volume (MTV) and total lesion glycolysis (TLG), based on an isocontur of 50% of SUVmax ...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755845/determination-of-binding-affinity-of-molecular-imaging-agents-for-steroid-hormone-receptors-in-breast-cancer
#4
Kelley Salem, Manoj Kumar, Kyle C Kloepping, Ciara J Michel, Yongjun Yan, Amy M Fowler
16α-[18 F]Fluoro-17β-estradiol ([18 F]FES) and 21-[18 F]-Fluoro-16α,17α-[(R)-(1'-α-furylmethylidene)dioxyl]-19-norpregn-4-ene-3,20-dione ([18 F]FFNP) are being investigated as imaging biomarkers for breast cancer patients. Quantitative positron emission tomography (PET) reflects both total receptor content and binding affinity. To study factors that may alter radiopharmaceutical binding and impact PET accuracy, assays that can separate receptor amount from binding affinity are needed. The study purpose was to quantify the binding parameters of [18 F]FES and [18 F]FFNP in breast cancer...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755844/standard-osem-vs-regularized-pet-image-reconstruction-qualitative-and-quantitative-comparison-using-phantom-data-and-various-clinical-radiopharmaceuticals
#5
Judit Lantos, Erik S Mittra, Craig S Levin, Andrei Iagaru
We investigated the block sequential regularized expectation maximization (BSREM) algorithm. ACR phantom measurements with different count statistics and 60 PET/CT research scans from the GE Discovery 600 and 690 scanners were reconstructed using BSREM and the standard-of-care OSEM algorithm. Hot concentration recovery and cold contrast recovery were measured from the phantom data. Two experienced nuclear medicine physicians reviewed the clinical images blindly. Liver SNR liver and SUVmax of the smallest lesion detected in each patient were also measured...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755843/fdg-pet-ct-suvmax-and-iaslc-ats-ers-histologic-classification-a-new-profile-of-lung-adenocarcinoma-with-prognostic-value
#6
Marina Suárez-Piñera, José Belda-Sanchis, Alvaro Taus, Albert Sánchez-Font, Antoni Mestre-Fusco, Marcel Jiménez, Lara Pijuan
Quantitative analysis of glucose consumption measured by maximum standardized uptake value (SUVmax) in lung adenocarcinoma (LA) remains in discussion and metabolic information provided by FDG-PET is not included in cancer staging. The first aim of this work was to evaluate the correlation between SUVmax and different histologic subtypes of LA. The second aim was to establish the correlation between SUVmax and TNM, genetic mutations and prognostic. Glucose consumption of primary tumor was quantified using SUVmax in 112 patients with histologically-confirmed LA...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755842/lipopolysaccharide-endotoxemia-induces-amyloid-%C3%AE-and-p-tau-formation-in-the-rat-brain
#7
Li-Ming Wang, Qi Wu, Ryan A Kirk, Kevin P Horn, Ahmed H Ebada Salem, John M Hoffman, Jeffrey T Yap, Joshua A Sonnen, Rheal A Towner, Fernando A Bozza, Rosana S Rodrigues, Kathryn A Morton
Amyloid beta (Aβ) plaques are not specific to Alzheimer's disease and occur with aging and neurodegenerative disorders. Soluble brain Aβ may be neuroprotective and increases in response to neuroinflammation. Sepsis is associated with neurocognitive compromise. The objective was to determine, in a rat endotoxemia model of sepsis, whether neuroinflammation and soluble Aβ production are associated with Aβ plaque and hyperphosphorylated tau deposition in the brain. Male Sprague Dawley rats received a single intraperitoneal injection of 10 mg/kg of lipopolysaccharide endotoxin (LPS)...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29755841/quantitative-pet-of-liver-functions
#8
REVIEW
Susanne Keiding, Michael Sørensen, Kim Frisch, Lars C Gormsen, Ole Lajord Munk
Improved understanding of liver physiology and pathophysiology is urgently needed to assist the choice of new and upcoming therapeutic modalities for patients with liver diseases. In this review, we focus on functional PET of the liver: 1) Dynamic PET with 2-deoxy-2-[18 F]fluoro- D -galactose (18 F-FDGal) provides quantitative images of the hepatic metabolic clearance K met (mL blood/min/mL liver tissue) of regional and whole-liver hepatic metabolic function. Standard-uptake-value ( SUV ) from a static liver 18 F-FDGal PET/CT scan can replace K met and is currently used clinically...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29531863/open-letter-to-journal-editors-on-international-consensus-radiochemistry-nomenclature-guidelines
#9
Heinz H Coenen, Antony D Gee, Michael Adam, Gunnar Antoni, Cathy S Cutler, Yasuhisa Fujibayashi, Jae Min Jeong, Robert H Mach, Thomas L Mindt, Victor W Pike, Albert D Windhorst
No abstract text is available yet for this article.
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29531862/diagnostic-performance-of-pet-mr-in-the-evaluation-of-active-inflammation-in-crohn-disease
#10
Onofrio Antonio Catalano, Vincent Wu, Umar Mahmood, Alberto Signore, Mark Vangel, Andrea Soricelli, Marco Salvatore, Debra Gervais, Bruce R Rosen
This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Specificity for active inflammation was 74% for PET, 87% for MR, and 93% for PET/MR. Diagnostic accuracy was 84% for PET, 83% for MR, and 91% for PET/MR. In conclusion, PET/MR is significantly more accurate than either sub-modality alone and more specific than PET alone in the detection of active inflammation in patients with Crohn disease...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29531861/assessment-of-very-early-response-evaluation-with-18-f-fdg-pet-ct-predicts-survival-in-erlotinib-treated-nsclc-patients-a-comparison-of-methods
#11
Joan Fledelius, Anne Winther-Larsen, Azza A Khalil, Karin Hjorthaug, Jørgen Frøkiær, Peter Meldgaard
We evaluated whether changes in 18 F-Fluoro-D-Glucose (18 F-FDG)-uptake evaluated early during erlotinib treatment predict survival in non-small cell lung cancer (NSCLC) patients. Positron emission tomography (PET)/CT scans from 56 NSCLC patients before and after 7-10 days of erlotinib treatment were analyzed with four different methods: Visual evaluation and percentage change in lean body mass corrected standardized uptake values (SULs): SULpeak , SULmax and total lesion glycolysis (TLG). The semi-quantitative parameters abilities to predict progression free survival (PFS) and overall survival (OS) were compared and we found that percentage change in SULpeak , SULmax and TLG all correlated with PFS and OS with the strongest correlation found for TLG (R=0...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29531860/thalamic-and-basal-ganglia-metabolism-on-interictal-18-f-fdg-pet-in-temporal-lobe-epilepsy-an-suv-based-analysis
#12
Aditya Jain, Aaron F Struck, Kaitlin M Woo, Christine J Jaskowiak, Lance T Hall
The aim of this study was to investigate thalamic and basal ganglia (BG) metabolism in temporal lobe epilepsy (TLE) on interictal 18 F-FDG PET using standardized uptake value (SUV). Retrospective review of data was undertaken for patients who were surgically treated for medically intractable TLE. All patients underwent 18 F-FDG PET, MRI brain and EEG as preoperative workup, and subsequently underwent temporal lobe resection. Postoperative outcomes were analyzed as without or with residual disabling seizures...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29531859/synthesis-radiolabelling-and-evaluation-of-11-c-pb212-as-a-radioligand-for-imaging-sigma-1-receptors-using-pet
#13
Francesco Spinelli, Ahmed Haider, Annamaria Toscano, Maria Laura Pati, Claudia Keller, Francesco Berardi, Nicola Antonio Colabufo, Carmen Abate, Simon M Ametamey
The Sigma-1 receptor (Sig-1R) has been described as a pluripotent modulator of distinct physiological functions and its involvement in various central and peripheral pathological disorders has been demonstrated. However, further investigations are required to understand the complex role of the Sig-1R as a molecular chaperon. A specific PET radioligand would provide a powerful tool in Sig-1R related studies. As part of our efforts to develop a Sig-1R PET radioligand that shows antagonistic properties, we investigated the suitability of 1-(4-(6-methoxynaphthalen-1-yl)butyl)-4-methylpiperidine (designated PB212) for imaging Sig-1R...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29531858/preparation-and-evaluation-of-a-68-ga-labeled-rgd-containing-octapeptide-for-noninvasive-imaging-of-angiogenesis-biodistribution-in-non-human-primate
#14
Irina Velikyan, Örjan Lindhe
Monitoring general disease marker such as angiogenesis may contribute to the development of personalized medicine and improve therapy outcome. Readily availability of positron emitter based imaging agents providing quantification would expand clinical positron emission tomography (PET) applications. Generator produced 68 Ga provides PET images of high resolution and the half-life time frame is compatible with the pharmacokinetics of small peptides comprising arginine-glycine-aspartic acid (RGD) sequence specific to αv β3 integrin receptors...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29531857/adenoid-cystic-carcinoma-focus-on-heavy-ion-therapy-and-molecular-imaging
#15
REVIEW
Angelo Castello, Laura Olivari, Egesta Lopci
Surgery, radiation therapy and chemotherapy are the oldest modalities for cancer treatment. However, as part of a continuous research in medicine, in order to improve therapeutic precision and biological effectiveness, there is an increasing interest into the use of heavy particle (e.g. protons or heavy ions) in the treatment of solid tumors. However, the restricted availability of the technology has concentrated the expertise in highly specialized centers that take care and treat extreme cases and rare pathologies...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29348983/sparse-domain-approaches-in-dynamic-spect-imaging-with-high-performance-computing
#16
Hui Pan, Haoran Chang, Debasis Mitra, Grant T Gullberg, Youngho Seo
Iterative reconstruction algorithms often have relatively large computation time affecting their clinical deployment. This is especially true for 4D reconstruction in dynamic imaging (DI). In this work, we have shown how sparse domain approaches and parallelization for static 3D image reconstruction and 4D dynamic image reconstruction (directly from sinogram) in Single Photon Emission Computed Tomography (SPECT), without any intermediate 3D reconstructions, can improve computational efficiency. DI in SPECT is one of the hardest inverse problems in medical image reconstruction area and slow reconstruction is a challenge for this promising protocol...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29348982/pictorial-atlas-of-symptomatic-accessory-ossicles-by-18-f-sodium-fluoride-naf-pet-ct
#17
Sharjeel Usmani, Cherry Sit, Gopinath Gnanasegaran, Tim Van den Wyngaert, Fahad Marafi
Accessory ossicles are developmental variants which are often asymptomatic. When incidentally picked up on imaging, they are often inconsequential and rarely a cause for concern. However, they may cause pain or discomfort due to trauma, altered stress, and over-activity. Nuclear scintigraphy may play a role in the diagnosis and localizing pain generators. 18 F-Sodium Fluoride (NaF) is a PET imaging agent used in bone imaging. Although commonly used in imaging patients with cancer imaging malignancy, 18 F-NaF may be useful in the evaluation of benign bone and joint conditions...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29348981/development-of-a-clinically-feasible-11-c-pe2i-pet-method-for-differential-diagnosis-of-parkinsonism-using-reduced-scan-duration-and-automated-reference-region-extraction
#18
My Jonasson, Lieuwe Appel, Torsten Danfors, Dag Nyholm, Håkan Askmark, Andreas Frick, Jonas Engman, Tomas Furmark, Jens Sörensen, Mark Lubberink
[11 C]PE2I is a highly selective dopamine transporter PET ligand. Parametric images based on dynamic [11 C]PE2I scans, showing dopamine transporter availability (BPND ) and relative cerebral blood flow (R1 ), can be used in differential diagnosis of parkinsonism. This work aimed to investigate a shortened scan duration and automated generation of parametric images which are two prerequisites for routine clinical application. Twelve subjects with parkinsonism and seventeen healthy controls underwent 80 min dynamic [11 C]PE2I PET scans...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29348980/the-value-of-fdg-pet-ct-for-follow-up-of-patients-with-melanoma-a-retrospective-analysis
#19
Philip H Vensby, Grethe Schmidt, Andreas Kjær, Barbara M Fischer
The incidence of melanoma (MM) is among the fastest rising cancers in the western countries. Positron Emission Tomography with Computed Tomography (PET/CT) is a valuable non-invasive tool for the diagnosis and staging of patients with MM. However, research on the value of PET/CT in follow-up of melanoma patients is limited. This study assesses the diagnostic value of PET/CT for follow-up after melanoma surgery. This retrospective study includes patients with MM who performed at least one PET/CT scan after initial surgery and staging...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29348979/simplified-estimation-of-binding-parameters-based-on-image-derived-reference-tissue-models-for-dopamine-transporter-bindings-in-non-human-primates-using-18-f-fe-pe2i-and-pet
#20
Ikuo Odano, Andrea Varrone, Tetsuo Hosoya, Kazuya Sakaguchi, Balázs Gulyás, Parasuraman Padmanabhan, Krishna Kanta Ghosh, Chang-Tong Yang, Ilonka Guenther, Zhimin Wang, Raymond Serrano, Nevil Ghislain Chimon, Christer Halldin
The aim of this study on dopamine transporter binding by [18 F]FE-PE2I and PET was to describe an image-derived approach using reference tissue models: the Logan DVR approach and simplified reference tissue model (SRTM), the features of which were simple to operate and precise in the measurements. Using the approach, the authors sought to obtain binding images and parameters. [18 F]FE-PE2I and dynamic PET as well as an MRI was performed on three rhesus monkeys, and metabolite corrected arterial plasma inputs were obtained...
2017: American Journal of Nuclear Medicine and Molecular Imaging
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