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Scientific Reports

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https://www.readbyqxmd.com/read/30429582/activation-of-%C3%AE-7-nicotinic-acetylcholine-receptor-ameliorates-zymosan-induced-acute-kidney-injury-in-balb-c-mice
#1
Sherehan M Ibrahim, Muhammad Y Al-Shorbagy, Dalaal M Abdallah, Hanan S El-Abhar
Zymosan, a natural compound, provokes acute peritonitis and multiple organ dysfunction that affects the kidney, beside other organs via exaggerated inflammatory response. The aim of the present study is to test the role of cholinergic anti-inflammatory pathway (CAP) in alleviating acute kidney injury (AKI) induced by zymosan in BALB/c mice, using galantamine, a cholinesterase inhibitor, known to act via α7 nicotinic acetylcholine receptor (α7 nAChR) to stimulate CAP. Galantamine verified its anti-inflammatory effect by elevating acetylcholine (ACh) level, while abating the interleukin-6/ janus kinase 2 (Y1007/1008)/ signal transducer and activator of transcription 3 (Y705) (IL-6/ pY(1007/1008)-JAK2/ pY705-STAT3) inflammatory axis, with a consequent inhibition in suppressor of cytokine signaling 3 (SOCS3)...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429577/sendai-virus-infection-induces-expression-of-novel-rnas-in-human-cells
#2
Roli Mandhana, Curt M Horvath
Innate antiviral immune responses are driven by virus-induced changes in host gene expression. While much research on antiviral effectors has focused on virus-inducible mRNAs, recent genome-wide analyses have identified hundreds of novel target sites for virus-inducible transcription factors and RNA polymerase. These sites are beyond the known antiviral gene repertoire and their contribution to innate immune responses is largely unknown. In this study, RNA-sequencing of mock-infected and Sendai virus-infected cells was performed to characterize the virus-inducible transcriptome and identify novel virus-inducible RNAs (nviRNAs)...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429540/genome-wide-discovery-of-dna-polymorphisms-among-chickpea-cultivars-with-contrasting-seed-size-weight-and-their-functional-relevance
#3
Mohan Singh Rajkumar, Rohini Garg, Mukesh Jain
Seed size/weight is a major agronomic trait which determine crop productivity in legumes. To understand the genetic basis of seed size determination, we sought to identify DNA polymorphisms between two small (Himchana 1 and Pusa 362) and two large-seeded (JGK 3 and PG 0515) chickpea cultivars via whole genome resequencing. We identified a total of 75535 single nucleotide polymorphisms (SNPs), 6486 insertions and deletions (InDels), 1938 multi-nucleotide polymorphisms (MNPs) and 5025 complex variants between the two small and two large-seeded chickpea cultivars...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429539/non-mercaptalbumin-oxidized-form-of-serum-albumin-significantly-associated-with-renal-function-and-anemia-in-chronic-kidney-disease-patients
#4
Shinya Nakatani, Keiko Yasukawa, Eiji Ishimura, Ayumi Nakatani, Norikazu Toi, Hideki Uedono, Akihiro Tsuda, Shinsuke Yamada, Hitoshi Ikeda, Katsuhito Mori, Masanori Emoto, Yutaka Yatomi, Masaaki Inaba
Oxidative stress plays a major role in development of cardiovascular disease in patients with chronic kidney disease (CKD). Human mercaptalbumin (HMA), a reduced form of serum albumin, and non-mercaptalbumin (HNA), an oxidized form of serum albumin, are known as indicators for evaluating oxidative stress in systemic circulation, including end-stage renal disease cases. We investigated factors associated with fraction of HNA [f(HNA)] in 112 pre-dialysis CKD patients (63.6 ± 14.0 years old; 59 males, 53 females) using a newly established anion-exchange column packed with hydrophilic polyvinyl alcohol gel as well as high performance liquid chromatography...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429537/blocking-nuclear-export-of-hspa8-after-heat-shock-stress-severely-alters-cell-survival
#5
Fengjuan Wang, Srinivasa Reddy Bonam, Nicolas Schall, Lauriane Kuhn, Philippe Hammann, Olivier Chaloin, Jean-Baptiste Madinier, Jean-Paul Briand, Nicolas Page, Sylviane Muller
The nuclear translocation of endogenous heat shock cognate protein HSPA8 is a requisite for cell survival during oxidative and heat shock stress. Upon these events, cytoplasmic HSPA8 is thought to concentrate within the nucleus and nucleolus. When the situation returns to normal, HSPA8 is released from its nuclear/nucleolar anchors and redistributes into the cytoplasm. By using different stress conditions and a 21-mer phosphopeptide tool called P140, which binds HSPA8 and hampers its chaperone properties, we deciphered the cellular and molecular effects arising during this vital cytoplasmic-nuclear-cytoplasmic shuttling process...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429536/trpv2-is-required-for-mechanical-nociception-and-the-stretch-evoked-response-of-primary-sensory-neurons
#6
Kimiaki Katanosaka, Satomi Takatsu, Kazue Mizumura, Keiji Naruse, Yuki Katanosaka
Mechanotransduction plays important roles in many sensory processes, including touch, pain, hearing, and proprioception. However, the molecular mechanisms of mechanical nociception have remained unclear. Here, we showed that elimination of transient receptor potential vanilloid 2 (TRPV2) in mice resulted in the deficit of mechanical nociception due to the lack of mechanosensitivity in a subclass of adult primary sensory neurons (PSNs). The PSN-specific TRPV2-deficient mice showed behavioural impairment of mechanical nociception in tail-pressure and von Frey hair tests, without defects in axonal growth and neuronal composition...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429535/cerebral-motor-functional-connectivity-at-the-acute-stage-an-outcome-predictor-of-ischemic-stroke
#7
Nai-Fang Chi, Hsiao-Lun Ku, David Yen-Ting Chen, Ying-Chi Tseng, Chi-Jen Chen, Ying-Chin Lin, Yi-Chen Hsieh, Lung Chan, Hung-Yi Chiou, Chung Y Hsu, Chaur-Jong Hu
Sixty-seven patients with first acute ischemic stroke onset between 3 to 7 days and 25 age- and sex- matched controls were analyzed for the performance of a resting-state functional MRI to investigate whether the functional connectivity (FC) of the motor network in acute ischemic stroke is independently associated with functional outcomes. The FC of cortical motor network and default mode network was analyzed. The FC was compared between controls, patients with favorable outcomes (modified Rankin Scale, mRS ≤1), and patients with unfavorable outcomes (mRS ≥2) at 3 months...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429534/publisher-correction-environment-spectrum-and-coherence-behaviours-in-a-rare-earth-doped-crystal-for-quantum-memory
#8
Bo Gong, Tao Tu, Zhong-Quan Zhou, Xing-Yu Zhu, Chuan-Feng Li, Guang-Can Guo
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429533/correlative-light-electron-microscopy-detects-lipopolysaccharide-and-its-association-with-fibrin-fibres-in-parkinson-s-disease-alzheimer-s-disease-and-type-2-diabetes-mellitus
#9
Greta M de Waal, Lize Engelbrecht, Tanja Davis, Willem J S de Villiers, Douglas B Kell, Etheresia Pretorius
Many chronic diseases, including those classified as cardiovascular, neurodegenerative, or autoimmune, are characterized by persistent inflammation. The origin of this inflammation is mostly unclear, but it is typically mediated by inflammatory biomarkers, such as cytokines, and affected by both environmental and genetic factors. Recently circulating bacterial inflammagens such as lipopolysaccharide (LPS) have been implicated. We used a highly selective mouse monoclonal antibody to detect bacterial LPS in whole blood and/or platelet poor plasma of individuals with Parkinson's Disease, Alzheimer's type dementia, or Type 2 Diabetes Mellitus...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429528/two-contrasting-patterns-and-underlying-genes-for-coadaptation-of-seed-dormancy-and-flowering-time-in-rice
#10
Xing-You Gu, Wirat Pipatpongpinyo, Lihua Zhang, Yuliang Zhou, Heng Ye, Jiuhuan Feng
Association between seed dormancy (SD) and flowering time (FT) may generate a synergy in plant adaptation. This research aimed to identify patterns and underlying genes of the association in rice (Oryza sativa). Four F2 and two BC1 F1 populations from crosses of weedy/cultivated rice, and two families of progeny lines from backcrosses were evaluated for variations in time to flowering and germination ability. The two measurements were correlated negatively in the F2 and BC1 F1 populations, but positively in advanced generations of the progeny lines...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429526/anomalously-high-geothermal-flux-near-the-south-pole
#11
T A Jordan, C Martin, F Ferraccioli, K Matsuoka, H Corr, R Forsberg, A Olesen, M Siegert
Melting at the base of the Antarctic Ice Sheet influences ice dynamics and our ability to recover ancient climatic records from deep ice cores. Basal melt rates are affected by geothermal flux, one of the least constrained properties of the Antarctic continent. Estimates of Antarctic geothermal flux are typically regional in nature, derived from geological, magnetic or seismic data, or from sparse point measurements at ice core sites. We analyse ice-penetrating radar data upstream of South Pole revealing a ~100 km long and 50 km wide area where internal ice sheet layers converge with the bed...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429525/evidence-for-mitigation-of-coral-bleaching-by-manganese
#12
Tom Biscéré, Christine Ferrier-Pagès, Antoine Gilbert, Thomas Pichler, Fanny Houlbrèque
Unprecedented mass coral bleaching events due to global warming and overall seawater pollution have been observed worldwide over the last decades. Although metals are often considered as toxic substances for corals, some are essential at nanomolar concentrations for physiological processes such as photosynthesis and antioxidant defenses. This study was designed to elucidate, the individual and combined effects of nanomolar seawater enrichment in manganese (Mn) and iron (Fe), on the main physiological traits of Stylophora pistillata, maintained under normal growth and thermal stress conditions...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429524/administration-of-hydrogen-rich-water-prevents-vascular-aging-of-the-aorta-in-ldl-receptor-deficient-mice
#13
Masumi Iketani, Kanako Sekimoto, Tsutomu Igarashi, Mayumi Takahashi, Masaki Komatsu, Iwao Sakane, Hiroshi Takahashi, Hideo Kawaguchi, Ritsuko Ohtani-Kaneko, Ikuroh Ohsawa
The main cause of arteriosclerosis is atherosclerosis in the aorta. Atherosclerosis is recognized as a chronic inflammatory condition that begins with the dysfunction or activation of arterial endothelium. Low-density lipoprotein (LDL) and especially its oxidized form play a key role in endothelial dysfunction and atherogenesis. Recent studies showed that senescent cells are involved in the development and progression of atherosclerosis, and eliminating senescent cells suppresses the senescence-associated secretory phenotype...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429523/achieving-acoustic-topological-valley-hall-states-by-modulating-the-subwavelength-honeycomb-lattice
#14
Zhiwang Zhang, Ying Cheng, Xiaojun Liu
Topological valley-contrasting physics is attracting increasing attention because of its potentials as a promising information carrier in electrics and classical systems. In this work, we reveal the valley-Hall effect and the valley projected edge states in two-dimensional sonic crystals with modulated acoustic honeycomb lattice. The sonic crystals are arranged by soft-material rods and thereby in a sub-wavelength scale, of which the lattice constant is only 0.267 times the wavelength and can be modulated to almost 0...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429522/polythermal-structure-of-a-himalayan-debris-covered-glacier-revealed-by-borehole-thermometry
#15
Katie E Miles, Bryn Hubbard, Duncan J Quincey, Evan S Miles, Tenzing C Sherpa, Ann V Rowan, Samuel H Doyle
Runoff from high-elevation debris-covered glaciers represents a crucial water supply for millions of people in the Hindu Kush-Himalaya region, where peak water has already passed in places. Knowledge of glacier thermal regime is essential for predicting dynamic and geometric responses to mass balance change and determining subsurface drainage pathways, which ultimately influence proglacial discharge and hence downstream water availability. Yet, deep internal ice temperatures of these glaciers are unknown, making projections of their future response to climate change highly uncertain...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429521/source-evaluation-of-137-cs-in-foodstuffs-based-on-trace-134-cs-radioactivity-measurements-following-the-fukushima-nuclear-accident
#16
Mayumi Hori, Takuya Saito, Katsumi Shozugawa
We performed gamma-ray analysis to determine the amount of radioactive cesium-134 (134 Cs) and cesium-137 (137 Cs) in 259 foodstuffs five years after the Fukushima nuclear accident of 2011. Using measurements of trace 134 Cs radioactivity, we investigated the contribution ratio of 137 Cs derived from the Fukushima accident on 2011 and pre-Fukushima. The median detected concentration of radiocesium (134 Cs + 137 Cs) in foodstuffs was 0.33 Bq/kg-raw, a much lower radioactivity than the Japanese regulatory limit...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429520/revised-role-for-hfq-bacterial-regulator-on-dna-topology
#17
Antoine Malabirade, David Partouche, Omar El Hamoui, Florian Turbant, Frédéric Geinguenaud, Pierre Recouvreux, Thomas Bizien, Florent Busi, Frank Wien, Véronique Arluison
Hfq is a pleiotropic regulator that mediates several aspects of bacterial RNA metabolism. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, usually via its interaction with small regulatory RNA. Besides these RNA-related functions, Hfq has also been described as one of the nucleoid associated proteins shaping the bacterial chromosome. Therefore, Hfq appears as a versatile nucleic acid-binding protein, which functions are probably even more numerous than those initially suggested...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429519/nucleation-and-growth-of-tial-3-intermetallic-phase-in-diffusion-bonded-ti-al-metal-intermetallic-laminate
#18
N Thiyaneshwaran, K Sivaprasad, B Ravisankar
A novel nucleation and growth phenomenon for TiAl3 intermetallic phase in Ti/Al diffusion couple is proposed based on diffusion kinetics. The interdiffusion and intrinsic diffusion co-efficients are calculated to make evident of dominant diffusion of Al towards Ti in Ti/Al diffusion couple obtained by solid state diffusion bonding. It was surprising to observe that the diffusion rate of Al was around 20 times higher than Ti with the formation of Kirkendall pores near the Al/TiAl3 interface. With such dominant diffusion of Al towards Ti, the nucleation and growth of TiAl3 intermetallic phase in Ti/Al couple happens mainly at the Ti/TiAl3 interface rather than Al/TiAl3 interface which is evident by the presence of very fine nearly nano-sized TiAl3 nuclei/grains near the Ti/TiAl3 interface...
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429517/publisher-correction-a-functional-variant-in-the-oas1-gene-is-associated-with-sj%C3%A3-gren-s-syndrome-complicated-with-hbv-infection
#19
Xianjun Liu, Hongcun Xing, Wenjing Gao, Di Yu, Yuming Zhao, Xiaoju Shi, Kun Zhang, Pingya Li, Jiaao Yu, Wei Xu, Hongli Shan, Kaiyu Zhang, Wanguo Bao, Xueqi Fu, Sirui Yang, Shaofeng Wang
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
November 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30429516/the-development-of-a-new-parameter-for-tracking-post-transcriptional-regulation-allows-the-detailed-map-of-the-pseudomonas-aeruginosa-crc-regulon
#20
Fernando Corona, Jose Antonio Reales-Calderón, Concha Gil, José Luis Martínez
Bacterial physiology is regulated at different levels, from mRNA synthesis to translational regulation and protein modification. Herein, we propose a parameter, dubbed post-transcriptional variation (PTV), that allows extracting information on post-transcriptional regulation from the combined analysis of transcriptomic and proteomic data. We have applied this parameter for getting a deeper insight in the regulon of the Pseudomonas aeruginosa post-transcriptional regulator Crc. P. aeruginosa is a free-living microorganism, and part of its ecological success relies on its capability of using a large number of carbon sources...
November 14, 2018: Scientific Reports
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