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Scientific Reports

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https://www.readbyqxmd.com/read/28541303/corrigendum-the-core-pattern-analysis-on-chinese-herbal-medicine-for-sj%C3%A3-gren-s-syndrome-a-nationwide-population-based-study
#1
Ching-Mao Chang, Hsueh-Ting Chu, Yau-Huei Wei, Fang-Pey Chen, Shengwen Wang, Po-Chang Wu, Hung-Rong Yen, Tzeng-Ji Chen, Hen-Hong Chang
This corrects the article DOI: 10.1038/srep09541.
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539670/simvastatin-and-bezafibrate-ameliorate-emotional-disorder-induced-by-high-fat-diet-in-c57bl-6-mice
#2
Hui Wang, Jia Zhou, Qiong Zhen Liu, Lu Lu Wang, Jing Shang
High fat diet (HFD)-induced metabolic disorders may lead to emotional disorders. This study aimed to explore the effect of simvastatin (SMV) and bezafibrate (BZ) on improving HFD-induced emotional changes, and tried to identify their different mechanisms. The intraperitoneal glucose tolerance test (IPGTT) was used to evaluate glucose control ability; and behavior tests including open field tests (OFT), forced swimming tests (FST), tail suspension tests (TST) and sucrose preference (SPT), were then performed to evaluate emotional changes...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539669/sensorimotor-adaptation-as-a-behavioural-biomarker-of-early-spinocerebellar-ataxia-type-6
#3
Muriel T N Panouillères, Raed A Joundi, Sonia Benitez-Riveiro, Binith Cheeran, Christopher R Butler, Andrea H Németh, R Chris Miall, Ned Jenkinson
Early detection of the behavioural deficits of neurodegenerative diseases may help to describe the pathogenesis of such diseases and establish important biomarkers of disease progression. The aim of this study was to identify how sensorimotor adaptation of the upper limb, a cerebellar-dependent process restoring movement accuracy after introduction of a perturbation, is affected at the pre-clinical and clinical stages of spinocerebellar ataxia type 6 (SCA6), an inherited neurodegenerative disease. We demonstrate that initial adaptation to the perturbation was significantly impaired in the eighteen individuals with clinical motor symptoms but mostly preserved in the five pre-clinical individuals...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539668/local-surface-plasmon-enhanced-polarization-and-internal-quantum-efficiency-of-deep-ultraviolet-emissions-from-algan-based-quantum-wells
#4
Cai Zhang, Ning Tang, Liangliang Shang, Lei Fu, Weiying Wang, Fujun Xu, Xinqiang Wang, Weikun Ge, Bo Shen
We report the enhancement of the polarization and internal quantum efficiency (IQE) of deep-UV LEDs by evaporating Al nanoparticles on the device surface to induce localized surface plasmons (LSPs). The deep-UV LEDs polarization is improved due to part of TM emission turns into TE emission through LSPs coupling. The significantly enhanced IQE is attributed to LSPs coupling, which suppress the participation of delocalized and dissociated excitons to non-radiative recombination process.
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539667/strontium-loaded-titania-nanotube-arrays-repress-osteoclast-differentiation-through-multiple-signalling-pathways-in-vitro-and-in-vivo-studies
#5
Baoguo Mi, Wei Xiong, Na Xu, Hanfeng Guan, Zhong Fang, Hui Liao, Yong Zhang, Biao Gao, Xiang Xiao, Jijiang Fu, Feng Li
The loosening of implants is an important clinical issue, particularly for patients with osteoporosis. In these patients, an implant should preferably both promote osteoblast differentiation and repress osteoclastic resorption. In the present study, we fabricated coatings containing TiO2 nanotubes (NTs) incorporated with strontium (Sr) on titanium (Ti) surfaces through hydrothermal treatment. The amount of loaded Sr was controlled by hydrothermally treating the samples in a Sr(OH)2 solution for 1 and 3 h (samples NT-Sr1h and NT-Sr3h, respectively) and found that both types of NT-Sr samples inhibited osteoclast differentiation by reducing the expression of osteoclast marker genes...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539664/mirna-29c-regulates-the-expression-of-inflammatory-cytokines-in-diabetic-nephropathy-by-targeting-tristetraprolin
#6
Jia Guo, Jing Li, Jing Zhao, Shuguang Yang, Luyao Wang, Genyang Cheng, Dong Liu, Jing Xiao, Zhangsuo Liu, Zhanzheng Zhao
Diabetic nephropathy is one of the most prevalent chronic complications of Diabetes mellitus, but its pathogenesis remains elusive. This study was designed to determine the role of tristetraprolin (TTP), inflammatory cytokines and microRNAs (miRNAs) in DN. The blood and urine samples were obtained from 32 patients with DN, 33 patients with type 2 DM, and 35 normal healthy subjects as controls. Renal tissue samples were also obtained from 10 DN patients and 10 normal controls. The miRNA microarray analyses were performed in pooled plasma and urine sediment samples of eight DN patients and eight age- and sex-matched health control subjects and three paired renal tissues from patients with DN and normal controls...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539663/modelling-farm-to-farm-disease-transmission-through-personnel-movements-from-visits-to-contacts-and-back
#7
Gianluigi Rossi, Rebecca L Smith, Stefano Pongolini, Luca Bolzoni
Infectious diseases in livestock can be transmitted through fomites: objects able to convey infectious agents. Between-farm spread of infections through fomites is mostly due to indirect contacts generated by on-farm visits of personnel that can carry pathogens on their clothes, equipment, or vehicles. However, data on farm visitors are often difficult to obtain because of the heterogeneity of their nature and privacy issues. Thus, models simulating disease spread between farms usually rely on strong assumptions about the contribution of indirect contacts on infection spread...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539662/extranodal-extension-of-lymph-node-metastasis-influences-recurrence-in-prostate-cancer-a-systematic-review-and-meta-analysis
#8
Claudio Luchini, Achim Fleischmann, Joost L Boormans, Matteo Fassan, Alessia Nottegar, Paola Lucato, Brendon Stubbs, Marco Solmi, Antonio Porcaro, Nicola Veronese, Matteo Brunelli, Aldo Scarpa, Liang Cheng
The extranodal extension (ENE) of nodal metastasis involves the extension of neoplastic cells through the lymph node capsule into the perinodal adipose tissue. This morphological feature has recently been indicated as an important prognostic factor in various cancer types, but its role in prostate cancer is still unclear. We aimed to clarify it, performing the first meta-analysis on this issue, comparing prognostic parameters in surgically treated, node-positive prostate cancer patients with (ENE+) vs. without (ENE-) ENE...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539661/the-pb2-mutation-with-lysine-at-627-enhances-the-pathogenicity-of-avian-influenza-h7n9-virus-which-belongs-to-a-non-zoonotic-lineage
#9
Weixuan Li, Horace Hok Yeung Lee, Run Feng Li, Huachen Maria Zhu, Guan Yi, Joseph Sriyal Malik Peiris, Zi Feng Yang, Chris Ka Pun Mok
A novel avian-origin influenza A (H7N9) virus emerged in China in 2013 and has caused zoonotic disease in over 1123 persons with an overall mortality around 30%. Amino acid changes at the residues 591, 627 and 701 of polymerase basic protein 2 (PB2) have been found frequently in the human H7N9 isolates but not in viruses isolated from avian species. We have recently identified a cluster of H7N9 viruses in ducks which circulated in China prior to the first recognition of zoonotic disease in 2013. These duck viruses have genetic background distinct from the zoonotic H7N9 lineage...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539660/a-soluble-starch-synthase-i-gene-ibssi-alters-the-content-composition-granule-size-and-structure-of-starch-in-transgenic-sweet-potato
#10
Yannan Wang, Yan Li, Huan Zhang, Hong Zhai, Qingchang Liu, Shaozhen He
Soluble starch synthase I (SSI) is a key enzyme in the biosynthesis of plant amylopectin. In this study, the gene named IbSSI, was cloned from sweet potato, an important starch crop. A high expression level of IbSSI was detected in the leaves and storage roots of the sweet potato. Its overexpression significantly increased the content and granule size of starch and the proportion of amylopectin by up-regulating starch biosynthetic genes in the transgenic plants compared with wild-type plants (WT) and RNA interference plants...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539659/involvement-of-the-bed-nucleus-of-the-stria-terminalis-in-l-dopa-induced-dyskinesia
#11
Matthieu F Bastide, Christelle Glangetas, Evelyne Doudnikoff, Qin Li, Mathieu Bourdenx, Pierre-Olivier Fernagut, Éric C Dumont, François Georges, Erwan Bézard
A whole brain immediate early gene mapping highlighted the dorsolateral bed nucleus of the stria terminalis (dlBST) as a structure putatively involved in L-3,4-dihydroxyphenylalanine (L-Dopa)-induced dyskinesia (LID), the debilitating side-effects of chronic dopamine replacement therapy in Parkinson's disease (PD). dlBST indeed displayed an overexpression of ∆FosB, ARC, Zif268 and FRA2 only in dyskinetic rats. We thus hypothesized that dlBST could play a role in LID hyperkinetic manifestations. To assess the causal role of the dlBST in LID, we used Daun02 inactivation to selectively inhibit the electrical activity of dlBST ΔFosB-expressing neurons...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539658/functional-compressive-mechanics-and-tissue-biocompatibility-of-an-injectable-sf-pu-hydrogel-for-nucleus-pulposus-replacement
#12
Jingen Hu, Yang Lu, Ling Cai, Kwabena Gyabaah Owusu-Ansah, Gewen Xu, Feilong Han, Junjie Bao, Xiangjin Lin, Yiping Huang
In spinal degenerative disease, an injectable liquid hydrogel can fill in defect entirely, lessen the danger of implant relocation and following loss of disc height, minimizing the operative trauma. Here, we propose an injectable in-situ chemically cross-linked hydrogel by a two-component reaction of liquid silk fibroin with liquid polyurethane at physiological temperature conditions. Confined compression tests and fatigue tests were reported to assess physical properties of the hydrogel. Impact of different diameter on the biomechanical behaviours was tested to evaluate the clinical potentiality of the hydrogel for replacing nucleus pulposus...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539657/using-bicistronic-constructs-to-evaluate-the-chaperone-activities-of-heat-shock-proteins-in-cells
#13
Rebecca San Gil, Tracey Berg, Heath Ecroyd
Heat shock proteins (Hsps) are molecular chaperones that prevent the aggregation of client proteins by facilitating their refolding, or trafficking them for degradation. The chaperone activities of Hsps are dependent on dynamic protein-protein interactions, including their oligomerisation into large multi-subunit complexes. Thus, tagging Hsps with fluorescent proteins can interfere with their chaperone activity. To overcome this limitation, we have exploited bicistronic constructs for the concurrent expression of a non-tagged Hsp and fluorescent reporter from a single mRNA in cells...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539656/pkc-%C3%AE-isoform-plays-a-crucial-role-in-tat-tlr4-signalling-pathway-to-activate-nf-%C3%AE%C2%BAb-and-cxcl8-production
#14
Manutea Serrero, Rémi Planès, Elmostafa Bahraoui
HIV-1 Tat protein induces the production of CXCL8 chemokine in a TLR4/MD2 and PKC dependent manner. The objective of this study was to understand whether these two pathways were distinct or constituted a single common pathway, and to determine the nature of the PKC isoforms involved and their interrelation with the activation of NF-κB and CXCL8 gene product expression. Here, we show that Tat-induced CXCL8 production is essentially dependent on the activation of PKC delta isoform, as shown a) by the capacity of PKC delta dominant negative (DN), and Rottlerin, a selective PKC delta pharmacological inhibitor, to inhibit Tat-induced CXCL8 production and b) by the ability of the constitutively active (CAT) isoform of PKC delta to induce CXCL8 production in a HEK cell line in the absence of Tat stimulation...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539655/angiopoietin-1-enhances-neutrophil-chemotaxis-in-vitro-and-migration-in-vivo-through-interaction-with-cd18-and-release-of-ccl4
#15
Amanda Burnett, Ingrid Gomez, David Davila De Leon, Mark Ariaans, Pavlos Progias, Richard A Kammerer, Guillermo Velasco, Marie Marron, Paul Hellewell, Victoria Ridger
Angiopoietins are a family of growth factors that are ligands for the tyrosine kinase receptor, Tie2. Angiopoietin 1 (Ang-1) is agonistic for Tie2, plays a key role in blood vessel maturation and stability and has been shown to possess anti-inflammatory properties. However, Tie2 expression has been demonstrated on human neutrophils and the observation that neutrophils migrate in response to Ang-1 in vitro has confounded research into its exact role in inflammation as well as its potential use as a therapeutic agent...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539654/quasispecies-composition-and-evolution-of-a-typical-zika-virus-clinical-isolate-from-suriname
#16
Sander van Boheemen, Ali Tas, S Yahya Anvar, Rebecca van Grootveld, Irina C Albulescu, Martijn P Bauer, Mariet C Feltkamp, Peter J Bredenbeek, Martijn J van Hemert
The arthropod-borne Zika virus (ZIKV) is currently causing a major international public health threat in the Americas. This study describes the isolation of ZIKV from the plasma of a 29-year-old female traveler that developed typical symptoms, like rash, fever and headache upon return from Suriname. The complete genome sequence including the 5' and 3' untranslated regions was determined and phylogenetic analysis showed the isolate clustering within the Asian lineage, close to other viruses that have recently been isolated in the Americas...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539653/a-second-mortuary-hiatus-on-lake-baikal-in-siberia-and-the-arrival-of-small-scale-pastoralism
#17
Robert J Losey, Andrea L Waters-Rist, Tatiana Nomokonova, Artur A Kharinskii
The spread of pastoralism in Asia is poorly understood, including how such processes affected northern forager populations. Lake Baikal's western shore has a rich Holocene archaeological record that tracks these processes. The Early Bronze Age here is evidenced by numerous forager burials. The Early Iron Age (EIA) is thought to mark the arrival of pastoralists, but archaeological remains from this period have received little analysis. New radiocarbon dates for EIA human remains from 23 cemeteries indicate that no burials were created along this shore for ~900 years...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539652/ano1-inhibits-cardiac-fibrosis-after-myocardial-infraction-via-tgf-%C3%AE-smad3-pathway
#18
Yao Gao, Yan Mei Zhang, Li Jun Qian, Ming Chu, Jian Hong, Di Xu
As a newly identified factor in calcium-activated chloride channel, ANO1 participates in various physiological processes like proliferation and differentiation, and expresses in human cardiac fibroblasts. In this experiment, we investigated the function of ANO1 in cardiac fibrosis after myocardial infraction (MI) with methods of Western blotting, Quantitative real-time PCR (qRT-PCR), metabolic reduction of 3-(4,5-dimethylthiozol-2-yl)-2, 5-diphenyltetrazo-lium bromide (MTT), immunofluorescence and confocal imaging, and Masson's trichrome staining...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539650/the-effect-of-two-amino-acid-residue-substitutions-via-rna-editing-on-dark-operative-protochlorophyllide-oxidoreductase-in-the-black-pine-chloroplasts
#19
Haruki Yamamoto, Junko Kusumi, Hisanori Yamakawa, Yuichi Fujita
Dark-operative protochlorophyllide oxidoreductase (DPOR) is a key enzyme to produce chlorophyll in the dark. Among photosynthetic eukaryotes, all three subunits chlL, chlN, and chlB are encoded by plastid genomes. In some gymnosperms, two codons of chlB mRNA are changed by RNA editing to codons encoding evolutionarily conserved amino acid residues. However, the effect of these substitutions on DPOR activity remains unknown. We first prepared cyanobacterial ChlB variants with amino acid substitution(s) to mimic ChlB translated from pre-edited mRNA...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539649/interspecies-interactions-reverse-the-hazard-of-antibiotics-exposure-a-plankton-community-study-on-responses-to-ciprofloxacin-hydrochloride
#20
Changyou Wang, Ziyang Wang, Yong Zhang, Rongguo Su
The ecotoxicological effects of Ciprofloxacin hydrochloride (CIP) were tested on population densities of plankton assemblages consisting of two algae (Isochrysis galbana and Platymonas subcordiformis) and a rotifer (Brachionus plicatilis). The I. galbana showed a significant decrease in densities when concentrations of CIP were above 2.0 mg L(-1) in single-species tests, while P. subcordiformis and B. plicatilis were stable in densities when CIP were less than10.0 mg L(-1). The equilibrium densities of I...
May 24, 2017: Scientific Reports
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