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Scientific Reports

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https://www.readbyqxmd.com/read/29789675/publisher-correction-structural-implications-of-mutations-conferring-rifampin-resistance-in-mycobacterium-leprae
#1
Sundeep Chaitanya Vedithi, Sony Malhotra, Madhusmita Das, Sheela Daniel, Nanda Kishore, Anuja George, Shantha Arumugam, Lakshmi Rajan, Mannam Ebenezer, David B Ascher, Eddy Arnold, Tom L Blundell
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
May 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789753/hydrogen-protects-lung-from-hypoxia-re-oxygenation-injury-by-reducing-hydroxyl-radical-production-and-inhibiting-inflammatory-responses
#2
Meihong Chen, Jie Zhang, Yun Chen, Yan Qiu, Zi Luo, Sixia Zhao, Lei Du, Dongbo Tian
Here we investigated whether hydrogen can protect the lung from chronic injury induced by hypoxia/re-oxygenation (H/R). We developed a mouse model in which H/R exposure triggered clinically typical lung injury, involving increased alveolar wall thickening, infiltration by neutrophils, consolidation, alveolar hemorrhage, increased levels of inflammatory factors and recruitment of M1 macrophages. All these processes were attenuated in the presence of H2 . We found that H/R-induced injury in our mouse model was associated with production of hydroxyl radicals as well as increased levels of colony-stimulating factors and circulating leukocytes...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789708/combined-genotyping-microbial-diversity-and-metabolite-profiling-studies-on-farmed-mytilus-spp-from-kiel-fjord
#3
Caroline Utermann, Delphine Parrot, Corinna Breusing, Heiko Stuckas, Tim Staufenberger, Martina Blümel, Antje Labes, Deniz Tasdemir
The blue mussel Mytilus is a popular food source with high economical value. Species of the M. edulis complex (M. edulis, M. galloprovincialis and M. trossulus) hybridise whenever their geographic ranges overlap posing difficulties to species discrimination, which is important for blue mussel aquaculture. The aim of this study was to determine the genetic structure of farmed blue mussels in Kiel Fjord. Microbial and metabolic profile patterns were studied to investigate a possible dependency on the genotype of the bivalves...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789702/parallel-descending-dopaminergic-connectivity-of-a13-cells-to-the-brainstem-locomotor-centers
#4
Sandeep Sharma, Linda H Kim, Kyle A Mayr, David A Elliott, Patrick J Whelan
The mesencephalic locomotor region (MLR) is an important integrative area for the initiation and modulation of locomotion. Recently it has been realized that dopamine (DA) projections from the substantia nigra pars compacta project to the MLR. Here we explore DA projections from an area of the medial zona incerta (ZI) known for its role in motor control onto the MLR. We provide evidence that dopaminergic (DAergic) A13 neurons have connectivity to the cuneiform nucleus (CnF) and pedunculopontine tegmental nucleus (PPTg) of the MLR...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789688/rapid-authentication-of-ginkgo-biloba-herbal-products-using-the-recombinase-polymerase-amplification-assay
#5
Yang Liu, Xiao-Yue Wang, Xue-Min Wei, Zi-Tong Gao, Jian-Ping Han
Species adulteration in herbal products (HPs) exposes consumers to health risks. Chemical and morphological methods have their own deficiencies when dealing with the detection of species containing the same active compounds in HPs. In this study, we developed a rapid identification method using the recombinase polymerase amplification (RPA) assay to detect two species, Ginkgo biloba and Sophora japonica (as adulteration), in Ginkgo biloba HPs. Among 36 Ginkgo biloba HP samples, 34 were found to have Ginkgo biloba sequences, and 9 were found to have Sophora japonica sequences...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789681/genomic-and-ecological-study-of-two-distinctive-freshwater-bacteriophages-infecting-a-comamonadaceae-bacterium
#6
Kira Moon, Ilnam Kang, Suhyun Kim, Sang-Jong Kim, Jang-Cheon Cho
Bacteriophages of freshwater environments have not been well studied despite their numerical dominance and ecological importance. Currently, very few phages have been isolated for many abundant freshwater bacterial groups, especially for the family Comamonadaceae that is found ubiquitously in freshwater habitats. In this study, we report two novel phages, P26059A and P26059B, that were isolated from Lake Soyang in South Korea, and lytically infected bacterial strain IMCC26059, a member of the family Comamonadaceae...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789674/tuning-alginate-gelatin-bioink-properties-by-varying-solvent-and-their-impact-on-stem-cell-behavior
#7
Zhao Li, Sha Huang, Yufan Liu, Bin Yao, Tian Hu, Haigang Shi, Jiangfan Xie, Xiaobing Fu
Bioink optimization is considered as one of main challenges in cell-laden 3D bioprinting. Alginate-Gelatin (Alg-Gel) hydrogel have been extensively used as bioink. However, its properties could be influenced by various parameters, and little is known about the evidence featuring the impact of solvent. Here we investigated four Alg-Gel bioink by varying solvent ionic strength (named B-1, B-2, B-3 and B-4). Mechanical properties and printability of bioink samples and their impacts on behaviors of encapsulated epidermal stem cells (ESCs) were tested...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789673/peatland-vegetation-composition-and-phenology-drive-the-seasonal-trajectory-of-maximum-gross-primary-production
#8
Matthias Peichl, Michal Gažovič, Ilse Vermeij, Eefje de Goede, Oliver Sonnentag, Juul Limpens, Mats B Nilsson
Gross primary production (GPP) is a key driver of the peatland carbon cycle. Although many studies have explored the apparent GPP under natural light conditions, knowledge of the maximum GPP at light-saturation (GPPmax ) and its spatio-temporal variation is limited. This information, however, is crucial since GPPmax essentially constrains the upper boundary for apparent GPP. Using chamber measurements combined with an external light source across experimental plots where vegetation composition was altered through long-term (20-year) nitrogen addition and artificial warming, we could quantify GPPmax in-situ and disentangle its biotic and abiotic controls in a boreal peatland...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789672/comparison-of-fast-track-versus-conventional-surgery-protocol-for-patients-undergoing-robot-assisted-laparoscopic-radical-prostatectomy-a-chinese-experience
#9
Zhichao Huang, Lu Yi, Zhaohui Zhong, Liang Zhu, Hongqing Zhao, Yijian Li, Yeqi Nian, Peng Xu, Yinhuai Wang
Fast-track surgery (FTS), which includes a series of evidence-based adjustments, is expected to reduce complications, relieve surgical stress reaction, accelerate recovery, and shorten hospitalization, as well as improve safety. The aim of this study was to critically evaluate the safety and effectiveness of FTS in Chinese prostate cancer (Pca) patients who underwent robot-assisted laparoscopic prostatectomy (RALP). A retrospective analysis was performed on 73 consecutive Chinese Pca patients who underwent RALP and who were divided into two groups: conventional surgery (CS) and FTS...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789671/wild-and-domesticated-moringa-oleifera-differ-in-taste-glucosinolate-composition-and-antioxidant-potential-but-not-myrosinase-activity-or-protein-content
#10
Gwen M Chodur, Mark E Olson, Kristina L Wade, Katherine K Stephenson, Wasif Nouman, Garima, Jed W Fahey
Taste drives consumption of foods. The tropical tree Moringa oleifera is grown worldwide as a protein-rich leafy vegetable and for the medicinal value of its phytochemicals, in particular its glucosinolates, which can lead to a pronounced harsh taste. All studies to date have examined only cultivated, domestic variants, meaning that potentially useful variation in wild type plants has been overlooked. We examine whether domesticated and wild type M. oleifera differ in myrosinase or glucosinolate levels, and whether these different levels impact taste in ways that could affect consumption...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789662/spraying-dynamics-in-continuous-wave-laser-printing-of-conductive-inks
#11
Pol Sopeña, Sergio González-Torres, Juan Marcos Fernández-Pradas, Pere Serra
Laser-induced forward transfer (LIFT), though usually associated with pulsed lasers, has been recently shown to be feasible for printing liquid inks with continuous wave (CW) lasers. This is remarkable not only because of the advantages that the new approach presents in terms of cost, but also because of the surprising transfer dynamics associated with it. In this work we carry out a study of CW-LIFT aimed at understanding the new transfer dynamics and its correlation with the printing outcomes. The CW-LIFT of lines of Ag ink at different laser powers and scan speeds revealed a range of conditions that allowed printing conductive lines with good electrical properties...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789661/a-correlative-and-quantitative-imaging-approach-enabling-characterization-of-primary-cell-cell-communication-case-of-human-cd4-t-cell-macrophage-immunological-synapses
#12
Richard Kasprowicz, Emma Rand, Peter J O'Toole, Nathalie Signoret
Cell-to-cell communication engages signaling and spatiotemporal reorganization events driven by highly context-dependent and dynamic intercellular interactions, which are difficult to capture within heterogeneous primary cell cultures. Here, we present a straightforward correlative imaging approach utilizing commonly available instrumentation to sample large numbers of cell-cell interaction events, allowing qualitative and quantitative characterization of rare functioning cell-conjugates based on calcium signals...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789657/the-cooh-terminal-domain-of-huntingtin-interacts-with-rhogef-kalirin-and-modulates-cell-survival
#13
Hollis McClory, Xiaolong Wang, Ellen Sapp, Leah W Gatune, Maria Iuliano, Chiu-Yi Wu, Gina Nathwani, Kimberly B Kegel-Gleason, Marian DiFiglia, Xueyi Li
Human huntingtin (Htt) contains 3144 amino acids and has an expanded polyglutamine region near the NH2 -terminus in patients with Huntington's disease. While numerous binding partners have been identified to NH2 -terminal Htt, fewer proteins are known to interact with C-terminal domains of Htt. Here we report that kalirin, a Rac1 activator, is a binding partner to C-terminal Htt. Kalirin and Htt co-precipitated from mouse brain endosomes and co-localized at puncta in NRK and immortalized striatal cells and primary cortical neurons...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789656/distribution-of-different-surface-modified-carbon-dots-in-pumpkin-seedlings
#14
Kun Qian, Huiyuan Guo, Guangcai Chen, Chuanxin Ma, Baoshan Xing
The distribution of surface modified carbon dots (CDs) in the pumpkin seedlings was studied by visualization techniques and their potential phytotoxicity was investigated at both the physiological and biochemical levels. The average size of carbon dots was approximately 4 nm. The fluorescent peaks of bared CDs, CD-PEI and CD-PAA were between 420 nm and 500 nm, indicating CDs could emit blue and green fluorescence. Fluorescent images showed that all three types of CDs could accumulate in the pumpkin roots and translocate to the shoots, although the distribution pattern of each CDs was obviously different...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789655/cigarette-smoke-promotes-hiv-infection-of-primary-bronchial-epithelium-and-additively-suppresses-cftr-function
#15
S Chinnapaiyan, R Dutta, J Bala, T Parira, M Agudelo, M Nair, H J Unwalla
Recurrent lung infections are a common cause of morbidity and mortality in people living with HIV and this is exacerbated in smokers even when administered combination antiretroviral therapy (cART). The incidence of pneumonia is increased with smoking and treatment interruption and is directly dependent on viral load in patients when adjusted for CD4 counts. CFTR dysfunction plays an important role in aberrant airway innate immunity as it is pivotal in regulating mucociliary clearance (MCC) rates and other antibacterial mechanisms of the airway...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789654/direct-observation-of-pitting-corrosion-evolutions-on-carbon-steel-surfaces-at-the-nano-to-micro-scales
#16
Peng Guo, Erika Callagon La Plante, Bu Wang, Xin Chen, Magdalena Balonis, Mathieu Bauchy, Gaurav Sant
The Cl- -induced corrosion of metals and alloys is of relevance to a wide range of engineered materials, structures, and systems. Because of the challenges in studying pitting corrosion in a quantitative and statistically significant manner, its kinetics remain poorly understood. Herein, by direct, nano- to micro-scale observations using vertical scanning interferometry (VSI), we examine the temporal evolution of pitting corrosion on AISI 1045 carbon steel over large surface areas in Cl- -free, and Cl- -enriched solutions...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789653/ring-quantum-cascade-lasers-with-twisted-wavefronts
#17
Rolf Szedlak, Thomas Hisch, Benedikt Schwarz, Martin Holzbauer, Donald MacFarland, Tobias Zederbauer, Hermann Detz, Aaron Maxwell Andrews, Werner Schrenk, Stefan Rotter, Gottfried Strasser
We demonstrate the on-chip generation of twisted light beams from ring quantum cascade lasers. A monolithic gradient index metamaterial is fabricated directly into the substrate side of the semiconductor chip and induces a twist of the light's wavefront. This significantly influences the obtained beam pattern, which changes from a central intensity minimum to a maximum depending on the discontinuity count of the metamaterial. Our design principle provides an interesting alternative to recent implementations of microlasers operating at an exceptional point...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789647/microbial-production-of-novel-sulphated-alkaloids-for-drug-discovery
#18
Eitaro Matsumura, Akira Nakagawa, Yusuke Tomabechi, Shinichi Ikushiro, Toshiyuki Sakaki, Takane Katayama, Kenji Yamamoto, Hidehiko Kumagai, Fumihiko Sato, Hiromichi Minami
Natural products from plants are useful as lead compounds in drug discovery. Plant benzylisoquinoline alkaloids (BIAs) exhibit various pharmaceutical activities. Although unidentified BIAs are expected to be of medicinal value, sufficient quantities of such BIAs, for biological assays, are sometimes difficult to obtain due to their low content in natural sources. Here, we showed that high productivity of BIAs in engineered Escherichia coli could be exploited for drug discovery. First, we improved upon the previous microbial production system producing (S)-reticuline, an important BIA intermediate, to obtain yields of around 160 mg/L, which was 4-fold higher than those of the previously reported highest production system...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789646/age-related-differences-in-limb-fat-free-mass-and-fat-mass-in-healthy-chinese-adults
#19
Mei Bai, Rui Wang, Linhao Zhu, Guixin Li, Dongya Yuan, Li Wang, Tianbo Jin
Fat mass (FM) and fat-free mass (FFM) are important elements to evaluate nutritional status. The aims of this study were to establish reference values for FM and FFM of limbs, develop percentile distributions and assess age-related regional differences in body composition by multifrequency bioelectrical impedance analyzer (BIA) in healthy adults. A cross-sectional study was conducted on 3419 healthy subjects, 1595 men and 1824 women. Regional FM and FFM were measured by BIA. FM in men remained stable in both upper and lower limbs, with reference values (25-75th percentile) of 1-1...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789645/author-correction-balance-between-estrogens-and-proinflammatory-cytokines-regulates-chemokine-production-involved-in-thymic-germinal-center-formation
#20
Nadine Dragin, Patrice Nancy, José Villegas, Régine Roussin, Rozen Le Panse, Sonia Berrih-Aknin
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
May 22, 2018: Scientific Reports
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