journal
Journals Journal of Clinical & Cellular...

Journal of Clinical & Cellular Immunology

https://read.qxmd.com/read/36742994/cytokine-deficiencies-in-patients-with-long-covid
#1
JOURNAL ARTICLE
Elizabeth Scp Williams, Thomas B Martins, Kevin S Shah, Harry R Hill, Mayte Coiras, Adam M Spivak, Vicente Planelles
Up to half of individuals who contract SARS-CoV-2 develop symptoms of long-COVID approximately three months after initial infection. These symptoms are highly variable, and the mechanisms inducing them are yet to be understood. We compared plasma cytokine levels from individuals with long-COVID to healthy individuals and found that those with long-COVID had 100% reductions in circulating levels of Interferon Gamma (IFNγ) and Interleukin-8 (IL-8). Additionally, we found significant reductions in levels of IL-6, IL-2, IL-17, IL-13, and IL-4 in individuals with long-COVID...
2022: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/34262794/combination-therapies-for-hpv-associated-malignancies
#2
JOURNAL ARTICLE
Claire Smalley Rumfield, Jeffrey Schlom, Caroline Jochems
Human papillomavirus (HPV)-associated malignancies cause almost all cases of cervical cancer in women, and a significant percentage of head and neck cancer, together totaling almost 5% of the global cancer burden, and representing an important public health issue. The approval and use of two prophylactic HPV vaccines, Gardasil® and Cervarix®, have significantly decreased infections with HPV, but unfortunately, prophylactic vaccination does not treat established infections or malignancies resulting from HPV...
2021: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/36304699/the-relative-abundance-of-monocyte-subsets-determines-susceptibility-to-perinatal-hepatic-inflammation
#3
JOURNAL ARTICLE
Sarah Mohamedaly, Anas Alkhani, Amar Nijagal
The devastating consequences of perinatal liver inflammation contribute to a pressing need to develop therapeutics for the diseases that underly this condition. Biliary atresia (BA) is a perinatal inflammatory disease of the liver that results in obliterative cholangiopathy and rapidly progresses to liver failure, requiring transplantation. The ability to develop targeted therapies requires an understanding of the immune mechanisms that mitigate perinatal liver inflammation. This article reviews our recent findings demonstrating that in a murine model of perinatal hepatic inflammation, Ly6cLo non-classical monocytes express a pro-reparative transcriptomic profile and that the relative abundance of Ly6cLo monocytes promotes resolution of perinatal liver inflammation, rendering neonatal pups resistant to disease...
2020: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/34295572/chromatin-dynamics-and-genetic-variation-combine-to-regulate-innate-immune-memory
#4
JOURNAL ARTICLE
Jennifer Kim, Annie Vogel Ciernia
Recent work by Ciernia et al. (2020) identified how genetic and epigenetic mechanisms interact to regulate innate immune memory in bone marrow derived macrophages. The authors examined the BTBR strain, a naturally occurring mouse model of Autism Spectrum Disorder (ASD) that captures the complex genetics, behavioral and immune dysregulation found in the human disorder. Immune cell cultures from the BTBR strain compared to the standard C57 showed hyper-responsive immune gene expression that was linked to altered chromatin accessibility at sites with genetic differences between the strains...
2020: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/33335790/long-non-coding-rna-hotairm1-promotes-s100a9-support-of-mdsc-expansion-during-sepsis
#5
JOURNAL ARTICLE
Tuqa Alkhateeb, Isatou Bah, Ajinkya Kumbhare, Dima Youssef, Zhi Q Yao, Charles E McCall, Mohamed El Gazzar
Myeloid-derived suppressor cells (MDSCs) expand during mouse and human sepsis, but the mechanism responsible for this is unclear. We previously reported that nuclear transport of S100A9 protein programs Gr1+ CD11b+ myeloid precursors into MDSCs in septic mice. Here, we show that long non-coding RNA Hotairm1 converts MDSCs from an activator to a repressor state. Mechanistically, increased Hotairm1 expression in MDSCs in mice converted S100A9 from a secreted proinflammatory mediator to an immune repressor by binding to and shuttling it from cytosol to nucleus during late sepsis...
2020: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/32523798/increased-plasma-cells-and-decreased-b-cells-in-tumor-infiltrating-lymphocytes-are-associated-with-worse-survival-in-lung-adenocarcinomas
#6
JOURNAL ARTICLE
Hee Eun Lee, Lei Luo, Trynda Kroneman, Marie R Passow, Kristina M Del Rosario, Michael R Christensen, Mary E Francis, John W O'Shaughnessy, Anthony J Blahnik, Ping Yang, Eunhee S Yi
Introduction: Clinical significance of tumor-infiltrating plasma cells and B-cells in lung adenocarcinoma is not well known. Methods: CD3, CD20 and MUM1 immunostains were performed on representative tumor blocks selected from 120 consecutive lung adenocarcinoma cases treated by surgical resection at Mayo Clinic Rochester. CD3+ T-cells, CD20+ B-cells, and MUM1+ plasma cells were enumerated separately in the intraepithelial (IE) compartment and the stroma (ST) by digital image analyses using whole sections...
2020: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/31328022/why-don-t-we-have-a-vaccine-against-autoimmune-diseases-a-review
#7
JOURNAL ARTICLE
Ken S Rosenthal, Roy Carambula, Daniel H Zimmerman
This review examines some of the reasons why we don't have a vaccine against autoimmune diseases and highlights the progress that has been made. Many autoimmune diseases, such as rheumatoid arthritis (RA), multiple sclerosis (MS) and type 1 diabetes (T1D), are driven by autoimmune T cell responses. Unlike vaccines for most infectious diseases, which elicit antibody responses, are intended for immuno-naive individuals and considered preventative, a vaccine for an autoimmune disease must be therapeutic and resolve or control the on-going autoimmune response and condition in the diseased host...
2019: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/30956892/achieving-sustained-viral-remission-in-patients-with-chronic-hcv-infection-and-cryoglobulinemic-vasculitis-does-not-always-correlate-with-normalization-of-the-serologic-markers
#8
JOURNAL ARTICLE
Aaron Stubbs, Corinne Kowal, Ali Askari, Donald D Anthony, Maya Mattar
Objective: We aim to describe the persistence of symptoms associated with HCV-associated cryoglobulinemic vasculitis following achievement of (SVR) with IFN- free direct acting antiviral (DAA) therapy. In particular, we describe the persistence of C4 hypocomplementemia and positive Rheumatoid Factor (RF). Methods: We analyzed a case series of four patients enrolled from the Cleveland VA and known to have chronic HCV infection complicated by mixed cryoglobulinemia...
October 3, 2018: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/30464859/a-missing-link-between-neuron-specific-enolase-release-and-poor-prognosis-in-aging-patients-with-b-cell-lymphoma
#9
JOURNAL ARTICLE
Rachel Polcyn, Jason God, Mollie Capone, Denise Matzelle, Naren L Banik, Azizul Haque
No abstract text is available yet for this article.
2018: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/30123671/the-emerging-roles-of-surfactant-protein-a-in-asthma
#10
JOURNAL ARTICLE
Alane Blythe C Dy, Sasipa Tanyaratsrisakul, Dennis R Voelker, Julie G Ledford
Asthma remains one of the most common respiratory diseases in both children and adults affecting up to 10% of the US population. Asthma is characterized by persistent symptoms, airway inflammation, airflow limitation and frequent exacerbations. Eosinophils are a key immune cell present in a large majority of asthmatics and their presence and dysregulation are clinically associated with more severe asthma. Surfactant protein A (SP-A) provides a first-line of defense in pulmonary innate immunity by virtue of its role in pathogen opsonization...
2018: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/29177105/investigating-molecular-connections-of-non-alcoholic-fatty-liver-disease-with-associated-pathological-conditions-in-west-virginia-for-biomarker-analysis
#11
JOURNAL ARTICLE
Dana L Sharma, Hari Vishal Lakhani, Rebecca L Klug, Brian Snoad, Rawan El-Hamdani, Joseph I Shapiro, Komal Sodhi
Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by a steatosis of the liver that may progress to more serious pathological conditions including: nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. As the prevalence of NAFLD has increased worldwide in recent years, pathophysiology and risk factors associated with disease progression of NAFLD are at the focus of many studies. NAFLD is related to and shares common serum biomarkers with cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome (MetS)...
October 2017: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/29226015/conserved-hiv-epitopes-for-an-effective-hiv-vaccine
#12
JOURNAL ARTICLE
Bikash Sahay, Cuong Q Nguyen, Janet K Yamamoto
Despite major advances in antiretroviral therapy against HIV-1, an effective HIV vaccine is urgently required to reduce the number of new cases of HIV infections in the world. Vaccines are the ultimate tool in the medical arsenal to control and prevent the spread of infectious diseases such as HIV/AIDS. Several failed phase-IIb to -III clinical vaccine trials against HIV-1 in the past generated a plethora of information that could be used for better designing of an effective HIV vaccine in the future. Most of the tested vaccine candidates produced strong humoral responses against the HIV proteins; however, failed to protect due to: 1) the low levels and the narrow breadth of the HIV-1 neutralizing antibodies and the HIV-specific antibody-dependent Fc-mediated effector activities, 2) the low levels and the poor quality of the anti-HIV T-cell responses, and 3) the excessive responses to immunodominant non-protective HIV epitopes, which in some cases blocked the protective immunity and/or enhanced HIV infection...
August 2017: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/28936366/constitutive-and-stress-induced-expression-of-ccl5-machinery-in-rodent-retina
#13
JOURNAL ARTICLE
D'Anne S Duncan, William M McLaughlin, Noah Vasilakes, Franklin D Echevarria, Cathryn R Formichella, Rebecca M Sappington
Signaling by inflammatory cytokines and chemokines is associated with neurodegeneration in disease and injury. Here we examined expression of the β-chemokine CCL5 and its receptors in the mouse retina and evaluated its relevance in glaucoma, a common optic neuropathy associated with sensitivity to intraocular pressure (IOP). Using quantitative PCR, fluorescent in situ hybridization, immunohistochemistry and quantitative image analysis, we found CCL5 mRNA and protein was constitutively expressed in the inner retina and synaptic layers...
June 2017: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/28868205/moving-in-and-out-dispersion-of-cells-in-self-generated-gradients
#14
JOURNAL ARTICLE
Christina H Stuelten
Migrating cells can influence the direction of their own migration by metabolizing chemoattractants present in their environment. This is illustrated by the dispersal of melanoma cells, which break down lysophosphatidic acid and generate a gradient with increasing concentrations of lysophosphatidic acid distant from the tumor. Melanoma cells can then disperse away from the tumor as they migrate in the self-generated lysophosphatidic acid gradient. Thus, dispersal of tumor cells during invasion of the surrounding stroma might be driven by chemotaxis of cells along self-generated chemoattractant gradients...
June 2017: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/28815154/spin-trapping-a-review-for-the-study-of-obesity-related-oxidative-stress-and-na-k-atpase
#15
JOURNAL ARTICLE
Athar Nawab, Alexandra Nichols, Rebecca Klug, Joseph I Shapiro, Komal Sodhi
Reactive oxygen species (ROS) have gained attention with mounting evidence of their importance in cell signaling and various disease states. ROS is produced continuously as a natural by-product of normal oxygen metabolism. However, high levels ROS causes oxidative stress and damage to biomolecules. This results in loss of protein function, DNA cleavage, lipid peroxidation, or ultimately cell injury or death. Obesity has become a worldwide epidemic; studies show fat accumulation is associated with increased ROS and oxidative stress...
June 2017: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/28758047/the-role-of-the-ikaros-family-of-transcription-factors-in-regulatory-t-cell-development-and-function
#16
JOURNAL ARTICLE
Amara Seng, Thomas M Yankee
Regulatory T (Treg) cells are a subset of immune cells that maintain homeostasis by promoting immune tolerance and suppressing the immune response via a variety of mechanisms such as secreting cytokines, killing reactive immune cells, and inducing anergy. Dysfunction of Treg cells has been implicated in inflammatory diseases such as autoimmunity and transplant rejection. Conversely, too many or hyperresponsive Treg cells has been observed in cancer and chronic infections. Treg cells have proven to be difficult to study as there are no definitive Treg surface markers...
April 2017: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/28367355/glyceryl-tribenzoate-a-flavoring-ingredient-inhibits-the-adoptive-transfer-of-experimental-allergic-encephalomyelitis-via-tgf-%C3%AE-implications-for-multiple-sclerosis-therapy
#17
JOURNAL ARTICLE
Susanta Mondal, Sridevi Dasarathi, Kalipada Pahan
Multiple sclerosis (MS) is the most common autoimmune demyelinating disease of the central nervous system (CNS). Here, we have explored a novel use of glyceryl tribenzoate (GTB), a flavoring ingredient, in ameliorating the disease process of experimental allergic encephalomyelitis (EAE), an animal model of MS, via TGF-β. Oral feeding of GTB suppressed clinical symptoms of adoptively-transferred relapsing-remitting (RR) EAE in recipient mice and suppressed the generation of encephalitogenic T cells in donor mice...
February 2017: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/33178482/role-of-fc%C3%AE-receptor-mediated-inflammation-in-immune-neuropathies
#18
JOURNAL ARTICLE
Gang Zhang, Kazim A Sheikh
No abstract text is available yet for this article.
2017: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/29487479/islet-autoantibody-detection-by-electrochemiluminescence-ecl-assay
#19
JOURNAL ARTICLE
Yong Gu, Zhiyuan Zhao, Hilary High, Tao Yang, Liping Yu
No abstract text is available yet for this article.
2017: Journal of Clinical & Cellular Immunology
https://read.qxmd.com/read/29430334/new-treatments-for-systemic-lupus-erythematosus-on-the-horizon-targeting-plasmacytoid-dendritic-cells-to-inhibit-cytokine-production
#20
JOURNAL ARTICLE
Laura M Davison, Trine N Jorgensen
Patients with systemic lupus erythematosus (SLE) often have elevated levels of type I interferon (IFN, particularly IFNα), a cytokine that can drive many of the symptoms associated with this autoimmune disorder. Additionally, the presence of autoantibody-secreting plasma cells contributes to the systemic inflammation observed in SLE and IFNα supports the survival of these cells. Current therapies for SLE are limited to broad immunosuppression or B cell-targeting antibody-mediated depletion strategies, which do not eliminate autoantibody-secreting plasma cells...
2017: Journal of Clinical & Cellular Immunology
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