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Journal of Clinical & Cellular Immunology

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https://www.readbyqxmd.com/read/27853628/tir-domain-containing-adapter-inducing-interferon-%C3%AE-trif-regulates-cxcr5-t-helper-cells-in-the-intestine
#1
Saravana Kanagavelu, Claudia Flores, Shinichiro Hagiwara, Jose Ruiz, Jinhee Hyun, Ei E Cho, Frank Sun, Laura Romero, David Q Shih, Masayuki Fukata
OBJECTIVE: Establishing an effective humoral immunity is an important host defense mechanism in intestinal mucosa. T follicular helper (Tfh) cells are a spectrum of CXCR5 expressing T helper cells that induce antigen-specific B cell differentiation. Because the differentiation of T helper cells is largely regulated by innate immunity, we addressed whether TRIF signaling regulates Tfh cell differentiation and its ability to trigger humoral immune responses in the intestine. METHOD: CD4(+)CXCR5(+) T cells, B cells, and plasma cells in the Peyer's patches (PPs) of WT and TRIF-deficient (Trif(LPS2)) mice were analyzed by flow cytometry at the baseline, 9 days post primary infection, and 7 days post-secondary infection with Y...
October 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27895978/cytokines-and-cytokine-receptors-involved-in-the-pathogenesis-of-alzheimer-s-disease
#2
Tomone Nagae, Kiho Araki, Yuki Shimoda, Lucia I Sue, Thomas G Beach, Yoshihiro Konishi
Inflammatory mechanisms are implicated in the pathology of Alzheimer's disease (AD). However, it is unclear whether inflammatory alterations are a cause or consequence of neurodegeneration leading to dementia. Clarifying this issue would provide valuable insight into the early diagnosis and therapeutic management of AD. To address this, we compared the mRNA expression profiles of cytokines in the brains of AD patients with "non-demented individuals with AD pathology" and non-demented healthy control (ND) individuals...
August 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27747135/multiple-defects-impair-the-hla-class-ii-antigen-presentation-capacity-of-burkitt-lymphoma
#3
Jason M God, Azizul Haque
No abstract text is available yet for this article.
August 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27747134/interleukin-6-a-constitutive-modulator-of-glycoprotein-130-neuroinflammatory-and-cell-survival-signaling-in-retina
#4
Franklin D Echevarria, Abigayle E Rickman, Rebecca M Sappington
OBJECTIVE: The interleukin-6 (IL-6) family of cytokines and their signal transducer glycoprotein (gp130) are implicated in inflammatory and cell survival functions in glaucoma. There are several avenues for interdependent modulation of IL-6 family members and gp130 signaling. Here we investigated whether IL-6 modulates gp130 and related neuroinflammatory, cell survival and regulatory signaling in both healthy and glaucomatous retina. METHODS: In naïve and glaucomatous (Microbead Occlusion Model), wildtype (WT) and IL-6 knockout (IL-6-/-) mice, we examined gp130 protein expression and localization, using western blot and immunohistochemistry...
August 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27656328/development-of-incvax-in-situ-cancer-vaccine-and-its-immune-response-in-mice-with-hepatocellular-cancer
#5
Xiaoqiang Qi, Samuel Sk Lam, Dai Liu, Dae Young Kim, Lixin Ma, Lu Alleruzzo, Wei Chen, Tomas Hode, Carolyn J Henry, Jussuf Kaifi, Eric T Kimchi, Guangfu Li, Kevin F Staveley-O'Carroll
Manipulation of immune system toward the rejection of established cancers has become the standard of care in some patients. Here we propose the development of an in situ autologous cancer vaccine, inCVAX, for the treatment of hepatocellular cancer (HCC). inCVAX is based on the induction of local immunogenic cancer cell death combined with local dendritic cell stimulation by intratumoral injection of the immune-activator N-dihydro-galacto-chitosan (GC). In a first set of experiments, cellular and molecular studies were performed to investigate the effect of inCVAX on immune activation in a murine model of HCC that we previously developed...
August 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27478681/impact-of-depression-and-inflammation-on-the-progression-of-hiv-disease
#6
Yainyrette Rivera-Rivera, Fabián J Vázquez-Santiago, Elinette Albino, María Del C Sánchez, Vanessa Rivera-Amill
The human immunodeficiency virus type 1 (HIV-1) epidemic has negatively affected over 40 million people worldwide. Antiretroviral therapy (ART) has improved life expectancy and changed the outcome of HIV-1 infection, making it a chronic and manageable disease. However, AIDS and non-AIDS comorbid illnesses persist during the course of infection despite the use of ART. In addition, the development of neuropsychiatric comorbidities (including depression) by HIV-infected subjects significantly affects quality of life, medication adherence, and disease prognosis...
June 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27453801/th17-cells-in-protection-from-tumor-or-promotion-of-tumor-progression
#7
M Rita I Young
The roles of inflammation and inflammatory cells such as Th17 cells in the development and progression of cancer have been extensively studied. However, the results have been varied, with conflicting conclusions. Most studies have focused on changes in inflammatory phenotypes once cancers have developed and disease is progressing. Far fewer studies have looked at the immune phenotypic changes that occur during progression of premalignant lesions to cancer. The impact of inflammation and, in particular, Th17 cells on tumor biology is summarized in this review, with a focus on the differences in the outcomes of studies...
June 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27446638/fc-receptor-like-proteins-in-pathophysiology-of-b-cell-disorder
#8
Mollie Capone, John Matthew Bryant, Natalie Sutkowski, Azizul Haque
Members of the family of Fc receptor-like (FcRL) proteins, homologous to FcγRI, have been identified by multiple research groups. Consequently, they have been described using multiple nomenclatures including Fc receptor homologs (FcRH), immunoglobulin superfamily receptor translocation-associated genes (IRTA), immunoglobulin-Fc-gp42-related genes (IFGP), Src homology 2 domain-containing phosphatase anchor proteins (SPAP), and B cell cross-linked by anti-immunoglobulin M-activating sequences (BXMAS). They are now referred to under a unified nomenclature as FCRL...
June 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27441095/mycobacterium-tuberculosis-induces-expansion-of-foxp3-positive-cd4-t-cells-with-a-regulatory-profile-in-tuberculin-non-sensitized-healthy-subjects-implications-for-effective-immunization-against-tb
#9
Christina S Hirsch, Roxana Rojas, Mianda Wu, Zahra Toossi
OBJECTIVE: Infection by MTB or exposure to MTB constituents is associated with intense microbial stimulation of the immune system, through both antigenic and TLR components, and induction of a milieu that is rich in pro-inflammatory/anti-inflammatory cytokines. Here, we addressed the basis of induced regulatory T-cell (iT-reg) expansion in response to MTB stimulation, in the absence of prior T cell antigen responsiveness. METHODS: PBMC from HIV-1 un-infected TST negative and TST positive control subjects were stimulated by virulent MTB H37Rv lysate (L), a French press preparation of MTB that includes all bacterial components...
June 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27398263/matrix-metalloproteinase-9-production-by-immortalized-human-chondrocyte-lines
#10
Charles J Malemud, Evan C Meszaros, Meredith A Wylie, Wissam Dahoud, Yelenna Skomorovska-Prokvolit, Sam Mesiano
We reported at the Keynote Forum of Immunology Summit-2015 that recombinant human (rh) TNF-α or rhIL-6 stimulated production of matrix metalloproteinase-9 (MMP-9) in the T/C28a2 and C-28/I2 human immortalized chondrocyte cell lines. Furthermore, we reported that tocilizumab (TCZ), a fully humanized monoclonal antibody which neutralizes IL-6-mediated signaling, inhibited the rhIL-6-mediated increase in the production of MMP-9. IL-6 is also a known activator of the JAK/STAT signaling pathway. In that regard, we evaluated the effect of rhIL-6 on total and phosphorylated Signal Transducer and Activator of Transcription by these chondrocyte lines which showed that whereas STAT3 was constitutively phosphorylated in T/C28a2 chondrocytes, rhIL-6 activated STAT3 in C-28/I2 chondrocytes...
June 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27313973/genetically-modified-t-cell-therapy-for-the-treatment-of-osteosarcoma-an-update
#11
Christopher DeRenzo, Stephen Gottschalk
No abstract text is available yet for this article.
April 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27308096/il-10-modulates-th17-pathogenicity-during-autoimmune-diseases
#12
Beichu Guo
The immune system is essential for host defense against pathogen infections; however dysregulated immune response may lead to inflammatory or autoimmune diseases. Elevated activation of both innate immune cells and T cells such as Th17 cells are linked to many autoimmune diseases, including Multiple Sclerosis (MS), arthritis and inflammatory bowel disease (IBD). To keep immune homeostasis, the immune system develops a number of negative feedback mechanisms, such as the production of anti-inflammatory cytokine IL-10, to dampen excessive production of inflammatory cytokines and uncontrolled activation of immune cells...
April 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27274907/restoration-of-retarded-influenza-virus-specific-immunoglobulin-class-switch-in-aged-mice
#13
Yongxin Zhang, Ying Wang, Monica Zhang, Lin Liu, Innocent N Mbawuike
OBJECTIVE: The declined immune response to infection causes significant higher morbidity and mortality in aging in spite of the coexisted hyperimmunoglobulinemia (HIG). This study is to reveal the cellular basis of HIG and mechanism of weakened HA-specific IgG response in aged mice and to test cell therapy in the treatment of age-related IgG antibody production deficiency with immunocyte adoptive transfer. METHODS: BALB/c mice was immunized with Influenza A/Taiwan vaccine and challenged with the same strain of virus...
April 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27274906/adoptive-transfer-of-dendritic-cells-expressing-fas-ligand-modulates-intestinal-inflammation-in-a-model-of-inflammatory-bowel-disease
#14
Edelmarie Rivera de Jesus, Raymond A Isidro, Myrella L Cruz, Harry Marty, Caroline B Appleyard
BACKGROUND: Inflammatory bowel diseases (IBD) are chronic relapsing inflammatory conditions of unknown cause and likely result from the loss of immunological tolerance, which leads to over-activation of the gut immune system. Gut macrophages and dendritic cells (DCs) are essential for maintaining tolerance, but can also contribute to the inflammatory response in conditions such as IBD. Current therapies for IBD are limited by high costs and unwanted toxicities and side effects. The possibility of reducing intestinal inflammation with DCs genetically engineered to over-express the apoptosis-inducing FasL (FasL-DCs) has not yet been explored...
April 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27213115/tolerance-of-tumor-specific-t-cells-in-melanoma-metastases
#15
Katherine A Waugh, Sonia M Leach, Jill E Slansky
No abstract text is available yet for this article.
April 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27182456/role-of-serum-biomarkers-in-early-detection-of-non-alcoholic-steatohepatitis-and-fibrosis-in-west-virginian-children
#16
Komal Sodhi, Lucas Bracero, Andrew Feyh, Alexandra Nichols, Krithika Srikanthan, Tariq Latif, Deborah Preston, Joseph I Shapiro, Yoram Elitsur
BACKGROUND: Obesity, an epidemic among West Virginia children, as well as insulin resistance (IR), is well-established contributors to nonalcoholic steatohepatitis (NASH). Progression of NASH can lead to hepatic fibrosis and cirrhosis, making early detection imperative. The standard for diagnosing NASH is histologically via liver biopsy, which is highly invasive and generally contraindicated in children. By studying serum biomarkers associated with NASH, we aim to identify high risk children who can benefit from a less invasive, alternative approach to the early detection of NASH...
February 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27066297/the-nacht-lrr-and-pyd-domains-containing-protein-3-nlrp3-inflammasome-mediates-inflammation-and-voiding-dysfunction-in-a-lipopolysaccharide-induced-rat-model-of-cystitis
#17
Francis M Hughes, James G Kennis, Melissa N Youssef, Danielle W Lowe, Brooke E Shaner, J Todd Purves
OBJECTIVE: NOD-like receptors (NLRs) sense sterile and non-sterile signals and form inflammasomes which trigger an inflammatory response through the activation of caspase-1 and release of IL-1β. Recently we have shown the presence of several NLRs in the bladder urothelia and demonstrated the importance of NLRP3 in bladder outlet obstruction and cyclophosphamide-induced cystitis, both models of sterile inflammation. In this study we explore a role for NLRP3 in mediating the response to LPS, a key antigen of uropathogenic bacteria...
February 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/27375925/antibodies-to-the-rna-binding-protein-heterogeneous-nuclear-ribonucleoprotein-a1-colocalize-to-stress-granules-resulting-in-altered-rna-and-protein-levels-in-a-model-of-neurodegeneration-in-multiple-sclerosis
#18
Joshua N Douglas, Lidia A Gardner, Hannah E Salapa, Michael C Levin
OBJECTIVE: Multiple sclerosis (MS) is the most common demyelinating disorder of the central nervous system (CNS). Data suggest that antibodies to CNS targets contribute to the pathogenesis of MS. MS patients produce autoantibodies to heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1). hnRNP A1 is an RNA binding protein (RBP) overexpressed in neurons that functions in pre-mRNA splicing, mRNA trafficking, and translation. Previously, we showed that anti-hnRNP A1 antibodies entered neuronal cells (in vitro) via clathrin-mediated endocytosis, caused mislocalization of endogenous hnRNP A1 protein and increased markers of neurodegeneration including decreased ATP concentration and apoptosis...
2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/26962470/the-metabolic-prospective-and-redox-regulation-of-macrophage-polarization
#19
Chao He, A Brent Carter
Macrophage plasticity is an important feature of these innate immune cells. Macrophage phenotypes are divided into two categories, the classically activated macrophages (CAM, M1 phenotype) and the alternatively activated macrophages (AAM, M2 phenotype). M1 macrophages are commonly associated with the generation of proinflammatory cytokines, whereas M2 macrophages are anti-inflammatory and often associated with tumor progression and fibrosis development. Macrophages produce high levels of reactive oxygen species (ROS)...
December 2015: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/26877890/immune-based-therapy-clinical-trials-in-hepatocellular-carcinoma
#20
Dai Liu, Kevin F Staveley-O'Carroll, Guangfu Li
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality and continues to increase. Current standard of care for patients with HCC only provides limited therapeutic benefit. Development of innovative strategies is urgently needed. Experience with immunotherapy in HCC is quite early, but rapidly rise in the recent 15 years. Multifaceted immune-based approaches have shown efficacy in achieving disease regression, representing the most promising new treatment approach. Here, we classify the ongoing or completed clinical trials in HCC in terms of the immune strategies to be used and assess their clinical outcomes...
December 2015: Journal of Clinical & Cellular Immunology
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