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Annals of Intensive Care

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https://www.readbyqxmd.com/read/29445887/lung-volumes-and-lung-volume-recruitment-in-ards-a-comparison-between-supine-and-prone-position
#1
Hernan Aguirre-Bermeo, Marta Turella, Maddalena Bitondo, Juan Grandjean, Stefano Italiano, Olimpia Festa, Indalecio Morán, Jordi Mancebo
BACKGROUND: The use of positive end-expiratory pressure (PEEP) and prone position (PP) is common in the management of severe acute respiratory distress syndrome patients (ARDS). We conducted this study to analyze the variation in lung volumes and PEEP-induced lung volume recruitment with the change from supine position (SP) to PP in ARDS patients. METHODS: The investigation was conducted in a multidisciplinary intensive care unit. Patients who met the clinical criteria of the Berlin definition for ARDS were included...
February 14, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29445884/acute-kidney-injury-epidemiology-risk-factors-and-outcomes-in-critically-ill-patients-16-25-years-of-age-treated-in-an-adult-intensive-care-unit
#2
Dana Y Fuhrman, Sandra Kane-Gill, Stuart L Goldstein, Priyanka Priyanka, John A Kellum
BACKGROUND: Most studies of acute kidney injury (AKI) have focused on older adults, and little is known about AKI in young adults (16-25 years) that are cared for in an adult intensive care unit (ICU). We analyzed data from a large single-center ICU database and defined AKI using the Kidney Disease Improving Global Outcomes criteria. We stratified patients 16-55 years of age into four age groups for comparison and used multivariable logistic regression to identify associations of potential susceptibilities and exposures with AKI and mortality...
February 14, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29445877/sodium-lactate-improves-renal-microvascular-thrombosis-compared-to-sodium-bicarbonate-and-0-9-nacl-in-a-porcine-model-of-endotoxic-shock-an-experimental-randomized-open-label-controlled-study
#3
Thibault Duburcq, Arthur Durand, Antoine Tournoys, Viviane Gnemmi, Valery Gmyr, François Pattou, Mercedes Jourdain, Fabienne Tamion, Emmanuel Besnier, Sebastien Préau, Erika Parmentier-Decrucq, Daniel Mathieu, Julien Poissy, Raphaël Favory
BACKGROUND: Sodium lactate seemed to improve fluid balance and avoid fluid overload. The objective of this study was to determine if these beneficial effects can be at least partly explained by an improvement in disseminated intravascular coagulation (DIC)-associated renal microvascular thrombosis. METHODS: Ancillary work of an interventional randomized open label controlled experimental study. Fifteen female "Large White" pigs (2 months old) were challenged with intravenous infusion of E...
February 14, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29442256/plasma-micrornas-levels-are-different-between-pulmonary-and-extrapulmonary-ards-patients-a-clinical-observational-study
#4
Yi Zheng, Song-Qiao Liu, Qin Sun, Jian-Feng Xie, Jing-Yuan Xu, Qing Li, Chun Pan, Ling Liu, Ying-Zi Huang
BACKGROUND: Mesenchymal stem cells (MSC) obviously alleviate the damage of the structure and function of pulmonary vascular endothelial cells (VEC). The therapeutic effects of MSC are significantly different between pulmonary ARDS (ARDSp) and extrapulmonary ARDS (ARDSexp). MicroRNAs (miRNAs), as important media of MSC regulating VEC, are not studied between ARDSp and ARDSexp. We aimed to explore the plasma levels difference of miRNAs that regulate VEC function and are associated with MSC (MSC-VEC-miRNAs) between ARDSp and ARDSexp patients...
February 13, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29427134/acute-kidney-injury-in-major-abdominal-surgery-incidence-risk-factors-pathogenesis-and-outcomes
#5
REVIEW
Joana Gameiro, José Agapito Fonseca, Marta Neves, Sofia Jorge, José António Lopes
Acute kidney injury (AKI) is a common complication in patients undergoing major abdominal surgery. Various recent studies using modern standardized classifications for AKI reported a variable incidence of AKI after major abdominal surgery ranging from 3 to 35%. Several patient-related, procedure-related factors and postoperative complications were identified as risk factors for AKI in this setting. AKI following major abdominal surgery has been shown to be associated with poor short- and long-term outcomes...
February 9, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29427117/delayed-cerebral-thrombosis-complicating-pneumococcal-meningitis-an-autopsy-study
#6
Joo-Yeon Engelen-Lee, Matthijs C Brouwer, Eleonora Aronica, Diederik van de Beek
BACKGROUND: Delayed cerebral thrombosis (DCT) is a devastating cerebrovascular complication in patients with excellent initial recovery of pneumococcal meningitis. The aetiology is unknown, but direct bacterial invasion, activation of coagulation or post-infectious immunoglobulin deposition has been suggested. METHODS: We studied histopathology of 4 patients with pneumococcal meningitis complicated by DCT. Results were compared with 8 patients who died of pneumococcal meningitis without DCT and 3 non-meningitis control cases...
February 9, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29427013/assessment-of-fluid-responsiveness-in-spontaneously-breathing-patients-a-systematic-review-of-literature
#7
REVIEW
Renato Carneiro de Freitas Chaves, Thiago Domingos Corrêa, Ary Serpa Neto, Bruno de Arruda Bravim, Ricardo Luiz Cordioli, Fabio Tanzillo Moreira, Karina Tavares Timenetsky, Murillo Santucci Cesar de Assunção
Patients who increase stoke volume or cardiac index more than 10 or 15% after a fluid challenge are usually considered fluid responders. Assessment of fluid responsiveness prior to volume expansion is critical to avoid fluid overload, which has been associated with poor outcomes. Maneuvers to assess fluid responsiveness are well established in mechanically ventilated patients; however, few studies evaluated maneuvers to predict fluid responsiveness in spontaneously breathing patients. Our objective was to perform a systematic review of literature addressing the available methods to assess fluid responsiveness in spontaneously breathing patients...
February 9, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29417295/the-effect-of-a-medication-reconciliation-program-in-two-intensive-care-units-in-the-netherlands-a-prospective-intervention-study-with-a-before-and-after-design
#8
Liesbeth B E Bosma, Nicole G M Hunfeld, Rogier A M Quax, Edmé Meuwese, Piet H G J Melief, Jasper van Bommel, SiokSwan Tan, Maaike J van Kranenburg, Patricia M L A van den Bemt
BACKGROUND: Medication errors occur frequently in the intensive care unit (ICU) and during care transitions. Chronic medication is often temporarily stopped at the ICU. Unfortunately, when the patient improves, the restart of this medication is easily forgotten. Moreover, temporal ICU medication is often unintentionally continued after ICU discharge. Medication reconciliation could be useful to prevent such errors. Therefore, the aim of this study was to determine the effect of medication reconciliation at the ICU...
February 7, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29404789/proceedings-of-r%C3%A3-animation-2018-the-french-intensive-care-society-international-congress
#9
(no author information available yet)
No abstract text is available yet for this article.
February 5, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29404723/physiological-predictors-of-respiratory-and-cough-assistance-needs-after-extubation
#10
Nicolas Terzi, Frédéric Lofaso, Romain Masson, Pascal Beuret, Hervé Normand, Edith Dumanowski, Line Falaize, Bertrand Sauneuf, Cédric Daubin, Jennifer Brunet, Djillali Annane, Jean-Jacques Parienti, David Orlikowski
BACKGROUND: Identifying patients at high risk of post-extubation acute respiratory failure requiring respiratory or mechanical cough assistance remains challenging. Here, our primary aim was to evaluate the accuracy of easily collected parameters obtained before or just after extubation in predicting the risk of post-extubation acute respiratory failure requiring, at best, noninvasive mechanical ventilation (NIV) and/or mechanical cough assistance and, at worst, reintubation after extubation...
February 5, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29396755/new-perspectives-to-improve-critical-care-benchmarking
#11
REVIEW
Jorge I F Salluh, Jean Daniel Chiche, Carlos Eduardo Reis, Marcio Soares
No abstract text is available yet for this article.
February 2, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29388048/pharmacogenomic-biomarkers-do-not-predict-response-to-drotrecogin-alfa-in-patients-with-severe-sepsis
#12
Djillali Annane, Jean-Paul Mira, Lorraine B Ware, Anthony C Gordon, Charles J Hinds, David C Christiani, Jonathan Sevransky, Kathleen Barnes, Timothy G Buchman, Patrick J Heagerty, Robert Balshaw, Nadia Lesnikova, Karen de Nobrega, Hugh F Wellman, Mauricio Neira, Alexandra D J Mancini, Keith R Walley, James A Russell
PURPOSE: To explore potential design for pharmacogenomics trials in sepsis, we investigate the interaction between pharmacogenomic biomarkers and response to drotrecogin alfa (activated) (DrotAA). This trial was designed to validate whether previously identified improved response polymorphisms (IRPs A and B) were associated with an improved response to DrotAA in severe sepsis. METHODS: Patients with severe sepsis at high risk of death, who received DrotAA or not, with DNA available were included and matched to controls adjusting for age, APACHE II or SAPS II, organ dysfunction, ventilation, medical/surgical status, infection site, and propensity score (probability that a patient would have received DrotAA given their baseline characteristics)...
January 31, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29383510/epidemiology-causes-evolution-and-outcome-in-a-single-center-cohort-of-1116-critically-ill-patients-with-hypoxic-hepatitis
#13
Astrid Van den Broecke, Laura Van Coile, Alexander Decruyenaere, Kirsten Colpaert, Dominique Benoit, Hans Van Vlierberghe, Johan Decruyenaere
BACKGROUND: Hypoxic hepatitis (HH) is a type of acute hepatic injury that is histologically characterized by centrilobular liver cell necrosis and that is caused by insufficient oxygen delivery to the hepatocytes. Typical for HH is the sudden and significant increase of aspartate aminotransferase (AST) in response to cardiac, circulatory or respiratory failure. The aim of this study is to investigate its epidemiology, causes, evolution and outcome. METHODS: The screened population consisted of all adults admitted to the intensive care unit (ICU) at the Ghent University Hospital between January 1, 2007 and September 21, 2015...
January 30, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29380080/reliability-of-respiratory-pressure-measurements-in-ventilated-and-non-ventilated-patients-in-icu-an-observational-study
#14
Clément Medrinal, Guillaume Prieur, Yann Combret, Aurora Robledo Quesada, Tristan Bonnevie, Francis Edouard Gravier, Eric Frenoy, Olivier Contal, Bouchra Lamia
BACKGROUND: Assessment of maximum respiratory pressures is a common practice in intensive care because it can predict the success of weaning from ventilation. However, the reliability of measurements through an intubation catheter has not been compared with standard measurements. The aim of this study was to compare maximum respiratory pressures measured through an intubation catheter with the same measurements using a standard mouthpiece in extubated patients. METHODS: A prospective observational study was carried out in adults who had been under ventilation for at least 24 h and for whom extubation was planned...
January 30, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29362986/transcutaneous-electromyographic-respiratory-muscle-recordings-to-quantify-patient-ventilator-interaction-in-mechanically-ventilated-children
#15
Alette A Koopman, Robert G T Blokpoel, Leo A van Eykern, Frans H C de Jongh, Johannes G M Burgerhof, Martin C J Kneyber
BACKGROUND: To explore the feasibility of transcutaneous electromyographic respiratory muscle recordings to automatically quantify the synchronicity of patient-ventilator interaction in the pediatric intensive care unit. METHODS: Prospective observational study in a tertiary paediatric intensive care unit in an university hospital. Spontaneous breathing mechanically ventilated children < 18 years of age were eligible for inclusion. Patients underwent a 5-min continuous recording of ventilator pressure waveforms and transcutaneous electromyographic signal of the diaphragm...
January 24, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29356958/comparison-between-a-nurse-led-weaning-protocol-and-weaning-based-on-physician-s-clinical-judgment-in-tracheostomized-critically-ill-patients-a-pilot-randomized-controlled-clinical-trial
#16
Nazzareno Fagoni, Simone Piva, Elena Peli, Fabio Turla, Elisabetta Pecci, Livio Gualdoni, Bertilla Fiorese, Frank Rasulo, Nicola Latronico
BACKGROUND: Weaning protocols expedite extubation in mechanically ventilated patients, yet the literature investigating the application in tracheostomized patients remains scarce. The primary objective of this parallel randomized controlled pilot trial (RCT) was to assess the feasibility and safety of a nurse-led weaning protocol (protocol) compared to weaning based on physician's clinical judgment (control) in tracheostomized critically ill patients. RESULTS: We enrolled 65 patients, 27 were in the protocol group and 38 in the control group...
January 22, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29349709/the-host-response-in-critically-ill-sepsis-patients-on-statin-therapy-a-prospective-observational-study
#17
Maryse A Wiewel, Brendon P Scicluna, Lonneke A van Vught, Arie J Hoogendijk, Aeilko H Zwinderman, René Lutter, Janneke Horn, Olaf L Cremer, Marc J Bonten, Marcus J Schultz, Tom van der Poll
BACKGROUND: Statins can exert pleiotropic anti-inflammatory, vascular protective and anticoagulant effects, which in theory could improve the dysregulated host response during sepsis. We aimed to determine the association between prior statin use and host response characteristics in critically ill patients with sepsis. METHODS: We performed a prospective observational study in 1060 patients admitted with sepsis to the mixed intensive care units (ICUs) of two hospitals in the Netherlands between January 2011 and July 2013...
January 18, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29349705/stool-cultures-at-the-icu-get-rid-of-it
#18
Carolin F Manthey, Darja Dranova, Martin Christner, Laura Berneking, Stefan Kluge, Ansgar W Lohse, Valentin Fuhrmann
BACKGROUND: Stool cultures for Campylobacter, Salmonella and Shigella and/or Yersinia spp. are frequently ordered in critically ill patients with diarrhea. The aim of this study is to analyze the diagnostic yield in a large cohort of critically ill patients. Therefore, we performed a cohort study at the Department of Intensive Care Medicine of a University Hospital (11 ICUs). RESULTS: From all patients who were admitted to the ICU between 2010 and 2015, stool cultures were taken from 2...
January 18, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29344743/response-to-different-furosemide-doses-predicts-aki-progression-in-icu-patients-with-elevated-plasma-ngal-levels
#19
Ryo Matsuura, Yohei Komaru, Yoshihisa Miyamoto, Teruhiko Yoshida, Kohei Yoshimoto, Rei Isshiki, Kengo Mayumi, Tetsushi Yamashita, Yoshifumi Hamasaki, Masaomi Nangaku, Eisei Noiri, Naoto Morimura, Kent Doi
BACKGROUND: Furosemide responsiveness (FR) is determined by urine output after furosemide administration and has recently been evaluated as a furosemide stress test (FST) for predicting severe acute kidney injury (AKI) progression. Although a standardized furosemide dose is required for FST, variable dosing is typically employed based on illness severity, including renal dysfunction in the clinical setting. This study aimed to evaluate whether FR with different furosemide doses can predict AKI progression...
January 17, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29340875/thromboelastography-based-anticoagulation-management-during-extracorporeal-membrane-oxygenation-a-safety-and-feasibility-pilot-study
#20
Mauro Panigada, Giacomo E Iapichino, Matteo Brioni, Giovanna Panarello, Alessandro Protti, Giacomo Grasselli, Giovanna Occhipinti, Cristina Novembrino, Dario Consonni, Antonio Arcadipane, Luciano Gattinoni, Antonio Pesenti
BACKGROUND: There is no consensus on the management of anticoagulation during extracorporeal membrane oxygenation (ECMO). ECMO is currently burdened by a high rate of hemostatic complications, possibly associated with inadequate monitoring of heparin anticoagulation. This study aims to assess the safety and feasibility of an anticoagulation protocol for patients undergoing ECMO based on thromboelastography (TEG) as opposed to an activated partial thromboplastin time (aPTT)-based protocol...
January 16, 2018: Annals of Intensive Care
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