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Medical Mycology Journal

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https://www.readbyqxmd.com/read/28566668/term-14
#1
(no author information available yet)
No abstract text is available yet for this article.
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28566667/dermatophyte-antigen-kit
#2
Yuichiro Tsunemi
The dermatophyte antigen kit uses monoclonal antibodies that react with polysaccharides present in the dermatophyte cell wall to detect dermatophyte antigens in specimens based on the principle of immunochromatography. Clinical studies showed that the kit was very useful in the diagnosis of tinea unguium but not tinea pedis. The kit was therefore further developed as an in vitro diagnostic tool for tinea unguium and was approved by the Pharmaceuticals and Medical Devices Agency of Japan. The kit's extraction solution can extract antigens from nail specimens quickly and efficiently...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28566666/treatment-and-prevention-of-oral-candidiasis-in-elderly-patients
#3
Hideo Sakaguchi
The incidence of oral candidiasis has increased in the elderly in recent years. Although the increase of the elderly population plays a big role in this rise of oral candidiasis, the broader recognition that elderly people have higher infection rates for oral candidiasis is considered to be also an important factor. Oral candidiasis can be categorized into three types. Pseudomembranous oral candidiasis is characterized by the appearance of white moss, erythematous oral candidiasis by the eruption of erythema, and hyperplastic oral candidiasis by mucosal hyperplasia...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28566665/treatment-of-tinea-pedis-in-elderly-patients-using-external-preparations
#4
Michiteru Otani
Infection rate of tinea pedis is high in the elderly, wherein treatment by a dermatologist should be considered to prevent infecting their family members. About 90 percent of cases with tinea pedis is treated only using external preparations. In treating the elderly with tinea pedis using external preparation, we should take into consideration that the elderly have thinner and weaker skin compared to younger people. There are many kinds of dosage form (cream, ointments, lotion, spray, and so on) for external preparations to treat tinea pedis...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28566664/remarkable-works-and-cases-in-the-history-of-medical-mycology-in-japan
#5
Katsutaro Nishimoto
Several pathogenic fungi and cases related to Japanese medical mycologists were reviewed. Trichosporon inkin (as Sarcinomyces inkin) was reported as a pathogen of scrotal lesion by Oho in 1921, and Trichosporon asahii was isolated from generalized keratotic lesions in 1922 by Akagi in Japan. They were once included in Trichophyton beigelii, but then based on revision using DNA molecular technology, were returned to their original names.Microsporum ferrugineum was reported by Ota as a causative dermatophyte of tinea capitis in Japan and surrounding areas...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28566663/promising-therapies-for-fungal-infection-based-on-the-study-to-elucidate-mechanisms-to-cope-with-stress-in-candida-species-translated-article
#6
Kazuyuki Hirai, Tatsuya Inukai, Hironobu Nakayama
In recent years, the incidence of fungal infections has been increasing, particularly among patients with immune systems compromised by human immunodeficiency virus infection, organ transplantation, and/or chemotherapy for cancer. Current therapies for treating systemic fungal infection have limited effectiveness and have created problems of adverse reactions and drug resistance. These issues therefore motivate us to develop novel antifungals. Elucidation of stress response mechanisms and virulence factors in pathogenic fungi is required in developing an effective antifungal strategy...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28566662/practical-management-of-deep-cutaneous-fungal-infections
#7
Tomotaka Sato
Understanding deep cutaneous fungal infection requires not only reading many case reports and checking the typical clinical images of skin lesions, but also managing the patients properly to prevent misdiagnosis. Herein, I review my recent experiences with eight typical cases of deep cutaneous infections (including protothecosis and nocardiosis) in Japan. It is very important to do the four management processes; namely, KOH direct microscopic examination, skin biopsy, fungal culture, and microscopic examination of the histopathological specimen of PAS and Grocott staining...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28566661/azole-resistant-aspergillus-fumigatus-containing-a-34-bp-tandem-repeat-in-cyp51a-promoter-is-isolated-from-the-environment-in-japan
#8
Kenji Onishi, Bolu Muhammad Sarumoh, Daisuke Hagiwara, Akira Watanabe, Katsuhiko Kamei, Takahito Toyotome
Azole-resistant strains of Aspergillus fumigatus containing a tandem repeat in the cyp51A promoter and amino acid substitution(s) have been isolated in the environment worldwide; however, this type of resistant strain had never been isolated from the environment in Japan. Our previous study indicated that an azole-resistant A. fumigatus strain OKH50 containing a 34-bp tandem repeat in cyp51A promoter with L98H substitution in Cyp51A was isolated from a patient in Obihiro of Hokkaido, Japan. In this study, we collected azole-resistant Aspergillus spp...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28566660/a-giant-dermatophyte-abscess-caused-by-trichophyton-rubrum-in-an-immunocompromised-patient
#9
Maiko Toyoki, Midori Hase, Yusuke Hirasawa, Takashi Umeyama, Yoshitsugu Miyazaki, Rui Kano, Takashi Sugita, Masataro Hiruma, Yuzo Kodama, Shigaku Ikeda
A 73-year-old male who had been receiving immunosuppressive drugs for 15 years developed a nodule on the left buttock region. The nodule slowly grew into a 15-cm fluctuant multilocular subcutaneous cyst. Serum beta-D-glucan levels were high, and the yellow purulent fluid obtained from the cyst was positive for Trichophyton rubrum. Granuloma formation in the cyst wall and large abscesses in the central cystic area were found, and septated hyphae were observed in both tissues. The cyst was surgically removed, and followed by itraconazole treatment...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28566659/effects-of-natural-and-chemically-defined-nutrients-on-candida-albicans-water-soluble-fraction-caws-vasculitis-in-mice
#10
Wataru Sato, Ken-Ichi Ishibashi, Daisuke Yamanaka, Yoshiyuki Adachi, Naohito Ohno
Kawasaki disease (KD) is an inflammatory disease that was identified by Professor Tomisaku Kawasaki in 1961. Candida albicans-derived substances, such as C. albicans water-soluble fraction (CAWS) , induce coronary arteritis similar to KD in mice. CAWS functions as a pathogen-associated molecular pattern (PAMP) by acting as a ligand for dectin-2. A gut-associated immunological system has developed specifically to segregate advantageous and detrimental stimuli, and the microbial flora has been found to markedly affect the development and severity of diseases...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28566658/erratum
#11
(no author information available yet)
No abstract text is available yet for this article.
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28250365/term-13
#12
(no author information available yet)
No abstract text is available yet for this article.
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28250364/epidemiological-study-of-fusarium-species-causing-invasive-and-superficial-fusariosis-in-japan
#13
Yasunori Muraosa, Misato Oguchi, Maki Yahiro, Akira Watanabe, Takashi Yaguchi, Katsuhiko Kamei
In Japan, Fusarium species are known etiological agents of human fungal infection; however, there has been no report of a large-scale epidemiological study on the etiological agents of fusariosis. A total of 73 Fusarium isolates from patients with invasive fusariosis (IF, n= 36) or superficial fusariosis (SF, n= 37), which were obtained at hospitals located in 28 prefectures in Japan between 1998 and 2015, were used for this study. Fusarium isolates were identified using Fusarium- and Fusarium solani species complex (FSSC) -specific real-time PCR and partial DNA sequences of the elongation factor-1 alpha (EF-1α) gene and the nuclear ribosomal internal transcribed spacer (ITS) region...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28250363/resistance-of-aspergillus-fumigatus-to-micafungin-is-increased-by-exogenous-%C3%AE-glucan
#14
Takashi Toyoshima, Ken-Ichi Ishibashi, Daisuke Yamanaka, Yoshiyuki Adachi, Naohito Ohno
Aspergillus species are ubiquitous in the environment and Aspergillus fumigatus can cause life-threatening infections in immunocompromised patients. β-1,3-/1,6-glucan is a major fungal cell wall polysaccharide that has various biological effects on the infected host, but little is known about the influence of β-glucan on the fungus itself. In a previous study, we demonstrated that the cell wall β-glucan content could be increased in Aspergillus spp. by addition of β-glucan to the culture medium. In this study, we investigated the influence of β-glucan on the susceptibility of A...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28250362/technical-aspects-and-applications-for-developing-in-situ-hybridization-procedures-for-formalin-fixed-and-paraffin-embedded-ffpe-tissues-for-diagnosis-of-fungal-infections
#15
Minoru Shinozaki, Naobumi Tochigi, Sota Sadamoto, Somay Yamagata Murayama, Megumi Wakayama, Tetsuo Nemoto, Kazutoshi Shibuya
Although histopathology is required for definitive diagnosis of fungal infections, conclusive identification and discrimination of fungi in tissue sections and cytological preparations remain technically difficult. Therefore, new diagnostic tools are needed for the routine diagnosis of pathogenic fungi. In situ hybridization (ISH) is a non-culture based procedure that has many advantages over traditional diagnostics for identification of pathogenic fungi in histological specimens. This review highlights the basic ISH technique, with particular emphasis on using pretreatment of tissue sections prior to hybridization to solve problems associated with formalin fixation...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28250361/a-patient-with-cystic-granuloma-trichophyticum-who-required-surgical-resection
#16
Takehiko Kaneko, Michiyo Kaneko
A 62-year-old male with numerous subcutaneous nodules in the lower extremities was referred to The University of Tokyo Hospital. The patient suffered from systemic lupus erythematosus (SLE), diabetes mellitus, and persisting hepatic dysfunction, and had been treated for SLE with oral prednisolone 20 mg/day and oral cyclosporine 3 mg/kg/day. The culture of scales collected from the patient's skin surface on Sabouraud's dextrose agar medium showed features of Trichophyton rubrum. Topically applied bifonazole cream was effective for tinea corporis, but oral griseofulvin 500 mg/day was discontinued after 2-month administration because of deteriorated liver function...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28250360/a-new-amino-acid-substitution-at-g150s-in-lanosterol-14-%C3%AE-demethylase-erg11-protein-in-multi-azole-resistant-trichosporon-asahii
#17
Hisako Kushima, Issei Tokimatsu, Hiroshi Ishii, Rie Kawano, Kentaro Watanabe, Jun-Ichi Kadota
The mechanisms of azole resistance in Trichosporon asahii have not yet been fully clarified. We previously showed that T. asahii has the ERG11 gene, coding lanosterol 14-α-demethylase (Erg11 protein; Erg11p), which is the primary target of azoles. A single amino acid substitution at G453R in Erg11p was found to induce changes in the affinity of this enzyme for azoles, especially fluconazole, in vitro. In the present study, we investigated the DNA sequences of the ERG11 gene using six different strains of clinically isolated T...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28250359/candida-albicans-adheres-to-chitin-by-recognizing-n-acetylglucosamine-glcnac
#18
Sanae A Ishijima, Tsuyoshi Yamada, Naho Maruyama, Shigeru Abe
The binding of Candida albicans cells to chitin was examined in a cell-binding assay. Microscopic observations indicated that both living and heat-killed Candida cells bound to chitin-coated substrates. C. albicans preferentially bound to chitin-coated plastic plates over chitosan-coated and uncoated plates. We prepared (125)I-labeled Candida cells for quantitative analysis of their binding to chitin. Heat-killed (125)I-labeled Candida cells bound to chitin-coated plates in a time-dependent manner until 1.5 hours after start of incubation at 4℃...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28250358/comprehensive-analysis-of-the-fungal-microbiota-of-the-human-external-auditory-canal-using-pyrosequencing
#19
Otomi Cho, Takashi Sugita
We previously reported that the Malassezia microbiota of the external auditory canal were composed principally of Malassezia slooffiae and Malassezia restricta. In the present study, the fungal microbiota of the external auditory canal were comprehensively analyzed by pyrosequencing on an FLX-454 platform. Of 17 samples tested, the fungal microbiota of 14 samples were composed of > 90% Malassezia species; either M. slooffiae or M. restricta was abundant in individual samples. The external auditory canal exhibits a lower fungal diversity than do other bodily sites...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/27904074/prophylactic-effect-of-lactobacillus-pentosus-strain-s-pt84-on-candida-infection-and-gastric-inflammation-in-a-murine-gastrointestinal-candidiasis-model-errata
#20
Toshihiro Maekawa, A Sanae Ishijima, Masayuki Ida, Takayuki Izumo, Yoshiko Ono, Hiroshi Shibata, Shigeru Abe
We previously showed a prophylactic effect of Lactobacillus pentosus strain S-PT84 against oral candidiasis in mice. In the present study, we evaluated the protective effect of S-PT84 against Candida infection of the gastrointestinal tract. As the first step, we used an in vitro assay to compare the inhibitory effects of several lactobacilli (S-PT84 and Lactobacillus pentosus type strain JCM1558(T), Lactobacillus gasseri type strain JCM1131(T) and Lactobacillus casei type strain JCM1134(T)) on mycelial growth of Candida albicans...
2016: Medical Mycology Journal
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