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Medical Mycology Journal

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https://www.readbyqxmd.com/read/30175815/-term-19
#1
(no author information available yet)
No abstract text is available yet for this article.
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/30175814/-lactosylceramide-enriched-lipid-raft-mediated-infection-immunity
#2
Kazuhisa Iwabuchi
More than 100 years have passed since Elie Metchnikoff discovered phagocytes. As molecular biological techniques have been developed and improved, we have gained deeper knowledge about the molecular mechanisms of immunological responses to invasion. The innate immune system is the inborn defense mechanism and the first line of defense against all kinds of pathogenic organisms, including bacteria, fungi, viruses, etc. Innate immunity was originally considered to comprise non-specific reactions. However, we now know that innate immune systems develop molecular mechanisms specific to pathogenic microorganisms...
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/30175813/-laser-therapies-for-onychomycosis-in-japan
#3
Utako Kimura, Yasushi Suga
Various treatment methods other than oral and topical antifungal medications have been employed to treat onychomycosis. Treatment methods include mechanical removal of the affected part of the nail plate by using a toenail cutter or grinder and chemical removal by using occlusive dressing therapy with salicylic acid plaster or urea cream. In recent years, laser therapies have received attention as modalities for treatment of onychomycosis. Favorable outcomes in patients with onychomycosis have been reported in Japan from treatment combining carbon dioxide laser and topical antifungal drug, treatment with photodynamic therapy, and treatment with Nd:YAG laser...
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/30175812/-identification-of-heparin-binding-proteins-on-the-cell-surface-of-cryptococcus-neoformans
#4
Reiko Ikeda, Tomoe Ichikawa, Yu-Ki Tsukiji, Kohei Kawamura, Ayano Kikuchi, Yo-Ichi Ishida, Yuki Ogasawara
Interactions between virulence factors of pathogens and host responses play an important role in the establishment of infection by microbes. We focused on interactions between Cryptococcus neoformans proteins and heparin, which is abundant on host epithelial cells. Surface proteins were extracted and analyzed. Fractions from anion-exchange column chromatography interacted with heparin in surface plasmon resonance analyses. Heparin-binding proteins were purified and then separated by gel electrophoresis; and were identified as transaldolase, glutathione-disulfide reductase, and glyoxal oxidase...
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/30175811/-next-generation-sequencing-analysis-of-bacterial-flora-in-bovine-prototheca-mastitic-milk
#5
Rui Kano, Yuki Kobayashi, Akitoyo Nishikawa, Ryo Murata, Takuya Itou, Takaaki Ito, Kazuyuki Suzuki, Hiroshi Kamata
Prototheca zopfii is an achlorophyllic algae that causes bovine mastitis, resulting in a reduction in milk production and the secretion of thin, watery milk with white flakes. The aim of the present study was to evaluate the bacterial flora in the udder environment in protothecal mastitis. We used metagenomic next-generation sequencing (NGS) analysis to identify 16S rRNA genes from bacterial flora present in milk samples from protothecal mastitic dairy cows.Seven clinical strains of P. zopfii genotype 2 were isolated from 7 milk samples from 7 cases (Holstein cow) of protothecal mastitis; another 9 milk samples were obtained from 9 normal Holstein cows...
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29848912/-erratum
#6
(no author information available yet)
No abstract text is available yet for this article.
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29848911/-term-18
#7
(no author information available yet)
No abstract text is available yet for this article.
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29848910/-investigation-of-virulence-factors-by-omics-approaches
#8
REVIEW
Azusa Takahashi-Nakaguchi, Daisuke Hagiwara, Hiroki Takahashi, Kanae Sakai, Takahito Toyotome, Akira Watanabe, Katsuhiko Kamei, Tohru Gonoi
 Aspergillus fumigatus is the predominant fungal pathogen responsible for life-threatening systemic infections in humans. Recently developed high-throughput whole genome sequencing (WGS) and RNA-Seq technologies have proven to be powerful tools for systematically investigating pathogenic organisms. In this review, we present new virulence factors obtained through our "omics" researches on A. fumigatus. We first sequenced genomes of A. fumigatus stains isolated from one infected patient at different time points, and made an important finding that although the genome (microsatellites) type of the infected strain remained unchanged, the strain exhibited several genetic changes, including acquiring therapeutic drug resistance, during patient treatment for 1...
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29848909/role-of-fks-gene-in-the-susceptibility-of-pathogenic-fungi-to-echinocandins
#9
Yasuhiro Hori, Kazutoshi Shibuya
Echinocandins are antifungal agents that specifically inhibit the biosynthesis of 1,3-β-D-glucan, a major structural component of fungal cell walls. Echinocandins are recommended as first-line or alternative/salvage therapy for candidiasis and aspergillosis in antifungal guidelines of various countries. Resistance to echinocandins has been reported in recent years. The mechanism of echinocandin resistance involves amino acid substitutions in hot spot regions of the FKS gene product, the catalytic subunit of 1,3-β-D-glucan synthase...
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29848908/infection-of-chick-chorioallantoic-membrane-cam-as-a-model-for-the-pathogenesis-of-cryptococcus-gattii
#10
Emmanuel Nnaemeka Nnadi, Ifeoma Bessie Enweani, Grace Mebi Ayanbimpe
The use of embryonated egg as an alternative in the study of the pathogenesis of fungi is evolving. Although murine models are the "gold standard," embryonated egg models are also used to screen determinants of virulence among fungi species. This study was aimed at determining the virulence potential of Cryptococcus gattii strains R265, R272, and EJB18, and Malassezia sympodialis using chorioallantoic membrane (CAM) of embryonated egg. At a concentration of 107 cfu/ml, C. gattii R272 was more virulent than R265 in the egg model, while EJB18 had low virulence...
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29491343/-term-17
#11
(no author information available yet)
No abstract text is available yet for this article.
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29491342/-reply-to-comments-on-my-article
#12
Yuichiro Tsunemi
No abstract text is available yet for this article.
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29491341/-erratum
#13
(no author information available yet)
No abstract text is available yet for this article.
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29491340/-inquiry-about-the-dermatopyte-test-strip
#14
Shinichi Watanabe
No abstract text is available yet for this article.
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29491339/-histopathological-diagnosis-of-invasive-fungal-infections-in-formalin-fixed-and-paraffin-embedded-tissues-in-conjunction-with-molecular-methods
#15
COMPARATIVE STUDY
Minoru Shinozaki, Naobumi Tochigi, Sota Sadamoto, Somay Yamagata Murayama, Megumi Wakayama, Tetsuo Nemoto
The main objective of this study was to evaluate the relationship between histopathology, polymerase chain reaction (PCR), and in situ hybridization (ISH) for the identification of causative fungi in formalin-fixed and paraffin-embedded (FFPE) tissue specimens. Since pathogenic fungi in tissue specimens can be difficult to identify morphologically, PCR and ISH have been usually employed as auxiliary procedures. However, little comparison has been made on the sensitivity and specificity of PCR and ISH using FFPE specimens...
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29491338/-national-trends-in-the-distribution-of-candida-species-causing-candidemia-in-japan-from-2003-to-2014
#16
Hiroshi Kakeya, Koichi Yamada, Yukihiro Kaneko, Katsunori Yanagihara, Kazuhiro Tateda, Shigefumi Maesaki, Yoshio Takesue, Kazunori Tomono, Jun-Ichi Kadota, Mitsuo Kaku, Yoshitsugu Miyazaki, Katsuhiko Kamei, Kazutoshi Shibuya, Yoshitiho Niki, Minoru Yoshida, Yoshihiro Sei
The Epidemiological Investigation Committee for Human Mycoses in Japan performed a retrospective epidemiological survey of candidemia and causative Candida species. Data from 2003 to 2014 were collected from 10 Japanese university hospitals. A total of 328,318 blood cultures were included. The prevalence of fungi in all cultures and in positive cultures were 0.58±0.09% and 4.46±0.66%, respectively. Among the results that were positive for Candida species (N=1,921), Candida albicans was the most common species (39...
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29491337/-ultrastructural-patterns-of-interactions-between-murine-lung-macrophages-and-yeast-cells-of-cryptococcus-neoformans-strains-with-different-virulence
#17
Amaliya Stepanova, Natalia Vasilyeva, Masashi Yamaguchi, Hiroji Chibana, Iliya Bosak, Larisa Filippova
This article presents the ultrastructural patterns of interactions between the murine lung macrophages and cells of low- (RKPGY-881, -1165, -1178) and high-virulence (RKPGY-1090, -1095, -1106) strains of Cryptococcus neoformans at the seventh post-experimental day. It was found that if macrophages ingest living yeast cells, the latter can: 1) become completely free from polysaccharide capsules, after that their contents undergo lysis, and cell wall debris are extruded from the macrophage (first scenario); 2) become partly free from their capsules, destroy the phagosomal plasma membrane and induce destructive processes inside the macrophage causing their death (second scenario); or 3) not lose their capsules and localize inside macrophage in latent state (third scenario)...
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29187723/-term-16
#18
(no author information available yet)
No abstract text is available yet for this article.
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/29187722/-the-plasma-1%C3%A2-3-%C3%AE-d-glucan-assay-a-japanese-contribution-to-the-diagnosis-of-invasive-fungal-infection
#19
REVIEW
Taminori Obayashi
 In 1985, a (1→3)-β-D-glucan assay based on the discovery of a (1→3)-β-D-glucan-sensitive coagulation factor in the horseshoe crab amebocytes was developed in Japan, as a test aid in the diagnosis of invasive fungal infections. After many clinical trials, it has now been incorporated in practice guidelines both in Japan and abroad for the diagnosis and management of invasive fungal infection, and is now available worldwide. In Japan, however, two commercial kits that differ widely in sensitivity to (1→3)-β-D-glucan are used; namely, the colorimetric and the turbidimetric assays...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/29187721/-survival-strategies-of-aspergillus-in-the-human-body
#20
REVIEW
Masato Tashiro, Koichi Izumikawa
 The human body is a hostile environment for Aspergillus species, which originally live outside the human body. There are lots of elimination mechanisms against Aspergillus inhaled into the human body, such as high body temperature, soluble lung components, mucociliary clearance mechanism, or responses of phagocytes. Aspergillus fumigatus, which is the primary causative agent of human infections among the human pathogenic species of Aspergillus, defend itself from the hostile human body environment by various mechanisms, such as thermotolerance, mycotoxin production, and characteristic morphological features...
2017: Medical Mycology Journal
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