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Integrated Blood Pressure Control

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https://www.readbyqxmd.com/read/27785095/consumption-of-nattokinase-is-associated-with-reduced-blood-pressure-and-von-willebrand-factor-a-cardiovascular-risk-marker-results-from-a-randomized-double-blind-placebo-controlled-multicenter-north-american-clinical-trial
#1
Gitte S Jensen, Miki Lenninger, Michael P Ero, Kathleen F Benson
OBJECTIVE: The objective of this study is to evaluate the effects of consumption of nattokinase on hypertension in a North American hypertensive population with associated genetic, dietary, and lifestyle factors. This is in extension of, and contrast to, previous studies on Asian populations. MATERIALS AND METHODS: A randomized, double-blind, placebo-controlled, parallel-arm clinical study was performed to evaluate nattokinase (NSK-SD), a fermented soy extract nattō from which vitamin K2 has been removed...
2016: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/27555797/current-best-practice-in-the-management-of-hypertensive-disorders-in-pregnancy
#2
REVIEW
Rosemary Townsend, Patrick O'Brien, Asma Khalil
Preeclampsia is a potentially serious complication of pregnancy with increasing significance worldwide. Preeclampsia is the cause of 9%-26% of global maternal mortality and a significant proportion of preterm delivery, and maternal and neonatal morbidity. Incidence is increasing in keeping with the increase in obesity, maternal age, and women with medical comorbidities entering pregnancy. Recent developments in the understanding of the pathophysiology of preeclampsia have opened new avenues for prevention, screening, and management of this condition...
2016: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/27175094/lercanidipine-enalapril-combination-in-the-management-of-obesity-related-hypertension
#3
REVIEW
Guido Grassi
Obesity-related hypertension represents a condition frequently observed in current clinical practice characterized by a complex pathophysiological background and a very high cardiovascular risk profile, particularly in severely obese individuals. This explains, on the one hand, the difficulty in reducing elevated blood pressure values in this pathological state and, on the other, the need to achieve this goal in a relatively short-time period to prevent the occurrence of fatal and nonfatal cardiovascular events...
2016: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/27103841/personalized-medicine-and-treatment-approaches-in-hypertension-current-perspectives
#4
REVIEW
James Brian Byrd
In the US, hypertension affects one in three adults. Current guideline-based treatment of hypertension involves little diagnostic testing. A more personalized approach to the treatment of hypertension might be of use. Several methods of personalized treatment have been proposed and vetted to varying degrees. The purpose of this narrative review is to discuss the rationale for personalized therapy in hypertension, barriers to its development and implementation, some influential examples of proposed personalization measures, and a view of future efforts...
2016: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/27051314/evaluation-and-treatment-of-hypertensive-crises-in-children
#5
REVIEW
Deborah R Stein, Michael A Ferguson
Hypertensive crises in children are medical emergencies that must be identified, evaluated, and treated promptly and appropriately to prevent end-organ injury and even death. Treatment in the acute setting typically includes continuous intravenous antihypertensive medications with monitoring in the intensive care unit setting. Medications commonly used to treat severe hypertension have been poorly studied in children. Dosing guidelines are available, although few pediatric-specific trials have been conducted to facilitate evidence-based therapy...
2016: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/27051313/effectiveness-of-continuous-positive-airway-pressure-in-lowering-blood-pressure-in-patients-with-obstructive-sleep-apnea-a-critical-review-of-the-literature
#6
REVIEW
Fernanda Fatureto-Borges, Geraldo Lorenzi-Filho, Luciano F Drager
Obstructive sleep apnea (OSA) is an extremely common comorbid condition in patients with hypertension, with a prevalence of ~50%. There is growing evidence suggesting that OSA is a secondary cause of hypertension, associated with both poor blood pressure (BP) control and target organ damage in patients with hypertension. The application of continuous positive airway pressure (CPAP) during sleep is the gold standard treatment of moderate- to-severe OSA and very effective in abolishing obstructive respiratory events...
2016: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/26955291/probiotics-and-blood-pressure-current-insights
#7
REVIEW
Aditya Upadrasta, Ratna Sudha Madempudi
Gut microbiota play a significant role in host metabolic processes, and recent metagenomic surveys have revealed that they are involved in host immune modulation and influence host development and physiology (organ development). Initially, probiotics are identified as potential therapeutics to treat gastrointestinal disorders and to revitalize the disturbed gut ecosystem. Currently, studies are exploring the potential for expanded uses of probiotics for improving the health conditions in metabolic disorders that increase the risk of developing cardiovascular diseases such as hypertension...
2016: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/26869812/chronic-resveratrol-reverses-a-mild-angiotensin-ii-induced-pressor-effect-in-a-rat-model
#8
Kevin L Gordish, William H Beierwaltes
Resveratrol is reported to reduce blood pressure in animal models of hypertension, but the mechanisms are unknown. We have shown that resveratrol infusion increases sodium excretion. We hypothesized that chronic ingestion of resveratrol would reduce angiotensin II (Ang II)-induced increases in blood pressure by decreasing oxidative stress and by also decreasing sodium reabsorption through a nitric oxide-dependent mechanism. We infused rats with vehicle or 80 μg Ang II/d over 4 weeks. Vehicle or Ang II-infused rats were individually housed, pair fed, and placed on a diet of normal chow or normal chow plus 146 mg resveratrol/d...
2016: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/26869811/the-effect-of-aged-garlic-extract-on-blood-pressure-and-other-cardiovascular-risk-factors-in-uncontrolled-hypertensives-the-age-at-heart-trial
#9
Karin Ried, Nikolaj Travica, Avni Sali
BACKGROUND: Hypertension affects 30% of adults worldwide. Garlic supplements have shown promise in the treatment of uncontrolled hypertension, and the mechanism of action is biologically plausible. Our trial is the first to assess the effect of aged garlic extract on central blood pressure and arterial stiffness, regarded as important risk factors for cardiovascular morbidity. SUBJECTS AND METHODS: A total of 88 general practice patients and community members with uncontrolled hypertension completed a double-blind randomized placebo-controlled trial of 12 weeks investigating the effect of daily intake of aged garlic extract (1...
2016: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/26869810/clinical-use-of-extended-release-oral-treprostinil-in-the-treatment-of-pulmonary-arterial-hypertension
#10
REVIEW
Steven C Pugliese, Todd M Bull
The development of parenteral prostacyclin therapy marked a dramatic breakthrough in the treatment of pulmonary arterial hypertension (PAH). Intravenous (IV) epoprostenol was the first PAH specific therapy and to date, remains the only treatment to demonstrate a mortality benefit. Because of the inherent complexities and risks of treating patients with continuous infusion IV therapy, there is great interest in the development of an oral prostacyclin analog that could mimic the benefits of IV therapy. Herein, we highlight the development of oral prostacyclin therapy, focusing on oral treprostinil, the only US Food and Drug Administration approved oral prostacyclin...
2016: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/26672761/renal-denervation-for-the-management-of-resistant-hypertension
#11
REVIEW
Hitesh C Patel, Carl Hayward, Vassilis Vassiliou, Ketna Patel, James P Howard, Carlo Di Mario
Renal sympathetic denervation (RSD) as a therapy for patients with resistant hypertension has attracted great interest. The majority of studies in this field have demonstrated impressive reductions in blood pressure (BP). However, these trials were not randomized or sham-controlled and hence, the findings may have been overinflated due to trial biases. SYMPLICITY HTN-3 was the first randomized controlled trial to use a blinded sham-control and ambulatory BP monitoring. A surprise to many was that this study was neutral...
2015: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/26316811/comparison-between-treadmill-and-bicycle-ergometer-exercise-tests-in-mild-to-moderate-hypertensive-nigerians
#12
Olugbenga O Abiodun, Michael O Balogun, Anthony O Akintomide, Rasaaq A Adebayo, Olufemi E Ajayi, Suraj A Ogunyemi, Valentine N Amadi, Victor O Adeyeye
BACKGROUND: Comparative cardiovascular responses to treadmill and bicycle ergometer (bike) exercise tests in hypertensive Nigerians are not known. This study compared cardiovascular responses to the two modes of exercise testing in hypertensives using maximal exercise protocols. METHODS: One hundred and ten male subjects with mild-to-moderate hypertension underwent maximal treadmill and bike test one after the other at a single visit in a simple random manner. Paired-sampled t-test was used to compare responses to both exercise tests while chi-squared test was used to compare categorical variables...
2015: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/26170715/does-home-blood-pressure-monitoring-improve-patient-outcomes-a-systematic-review-comparing-home-and-ambulatory-blood-pressure-monitoring-on-blood-pressure-control-and-patient-outcomes
#13
REVIEW
Tonya L Breaux-Shropshire, Eric Judd, Lee A Vucovich, Toneyell S Shropshire, Sonal Singh
OBJECTIVE: Our objective was to compare the clinical effectiveness of home blood pressure monitoring (HBPM) and 24-hour ambulatory blood pressure monitoring (ABPM) on blood pressure (BP) control and patient outcomes. DESIGN: A systematic review was conducted. We also appraised the methodological quality of studies. DATA SOURCES: PubMed, Scopus, CINAHL, and the Cochrane Central Register of Control Trials (CENTRAL). INCLUSION CRITERIA: Randomized control trials, prospective and retrospective cohort studies, observational studies, and case-control studies published in English from any year to present that describe HBPM and 24-hour ABPM and report on systolic and/or diastolic BP and/or heart attack, stroke, kidney failure and/or all-cause mortality for adult patients...
2015: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/26060413/vasomotor-sympathetic-outflow-in-the-muscle-metaboreflex-in-low-birth-weight-young-adults
#14
Jephat Chifamba, Brilliant Mbangani, Casper Chimhete, Lenon Gwaunza, Larry A Allen, Herbert Mapfumo Chinyanga
A growing body of evidence suggests that low birth weight (LBW) offspring are associated with long-term structural and functional changes in cardiovascular and neuroendocrine systems. We tested the hypothesis that muscle metaboreflex activation produces exaggerated responses in cardiac autonomic tone (represented by heart rate variability ratio) and cutaneous vascular sympathetic tone (represented by plethysmography pulse wave amplitude) in LBW compared to normal birth weight (NBW) young adults. We recruited 23 LBW (18 females and five males) and 23 NBW (14 females and nine males) University of Zimbabwe students with neonatal clinical cards as proof of birth weight at term...
2015: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/25897260/vitamin-d-status-and-hypertension-a-review
#15
REVIEW
Liang Ke, Rebecca S Mason, Maina Kariuki, Elias Mpofu, Kaye E Brock
Vitamin D is a steroid prohormone synthesized in the skin following ultraviolet exposure and also achieved through supplemental or dietary intake. While there is strong evidence for its role in maintaining bone and muscle health, there has been recent debate regarding the role of vitamin D deficiency in hypertension based on conflicting epidemiological evidence. Thus, we conducted a scoping systematic literature review and meta-analysis of all observational studies published up to early 2014 in order to map trends in the evidence of this association...
2015: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/25767405/risk-factors-and-effective-management-of-preeclampsia
#16
REVIEW
Fred A English, Louise C Kenny, Fergus P McCarthy
Preeclampsia, a hypertensive disorder of pregnancy is estimated to complicate 2%-8% of pregnancies and remains a principal cause of maternal and fetal morbidity and mortality. Preeclampsia may present at any gestation but is more commonly encountered in the third trimester. Multiple risk factors have been documented, including: family history, nulliparity, egg donation, diabetes, and obesity. Significant progress has been made in developing tests to predict risk of preeclampsia in pregnancy, but these remain confined to clinical trial settings and center around measuring angiogenic profiles, including placental growth factor or newer tests involving metabolomics...
2015: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/25733925/nitric-oxide-dysregulation-in-the-pathogenesis-of-preeclampsia-among-ghanaian-women
#17
Kwame Adu-Bonsaffoh, Daniel Ansong Antwi, Samuel Amenyi Obed, Ben Gyan
BACKGROUND: Preeclampsia (PE) is still a disease of theories as the exact cause remains uncertain. Widespread vascular endothelial cell dysfunction is thought to mediate the generalized vasospasm and hypertension characteristic of PE. Altered nitric oxide (NO) production has been associated with the endothelial dysfunction in the pathogenesis of PE but conflicting results have emerged from previous studies. OBJECTIVES: To determine maternal serum levels of NO, a biomarker of endothelial function, in nonpregnant, normal pregnant, and preeclamptic women...
2015: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/25525386/potential-of-garlic-allium-sativum-in-lowering-high-blood-pressure-mechanisms-of-action-and-clinical-relevance
#18
REVIEW
Karin Ried, Peter Fakler
Garlic supplements have shown promise in the treatment of uncontrolled hypertension, lowering blood pressure (BP) by about 10 mmHg systolic and 8 mmHg diastolic, similar to standard BP medication. Aged garlic extract, which contains S-allylcysteine as the bioactive sulfur compound, in particular is standardizable and highly tolerable, with little or no known harmful interaction when taken with other BP-reducing or blood-thinning medication. Here we describe biologically plausible mechanisms of garlic's BP-lowering effect...
2014: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/25473311/clinical-utility-of-fixed-dose-combinations-in-hypertension-evidence-for-the-potential-of-nebivolol-valsartan
#19
REVIEW
Jasmina Varagic, Henry Punzi, Carlos M Ferrario
Despite significant advances in pharmacologic approaches to treat hypertension during the last decades, hypertension- and hypertension-related organ damage are still a high health and economic burden because a large proportion of patients with hypertension do not achieve optimal blood pressure control. There is now general agreement that combination therapy with two or more antihypertensive drugs is required for targeted blood pressure accomplishment and reduction of global cardiovascular risk. The goals of combination therapies are to reduce long-term cardiovascular events by targeting different mechanism underlying hypertension and target organ disease, to block the counterregulatory pathways activated by monotherapies, to improve tolerability and decrease the adverse effects of up-titrated single agents, and to increase persistence and adherence with antihypertensive therapy...
2014: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/25278775/optimal-perioperative-management-of-arterial-blood-pressure
#20
REVIEW
Laurent Lonjaret, Olivier Lairez, Vincent Minville, Thomas Geeraerts
Perioperative blood pressure management is a key factor of patient care for anesthetists, as perioperative hemodynamic instability is associated with cardiovascular complications. Hypertension is an independent predictive factor of cardiac adverse events in noncardiac surgery. Intraoperative hypotension is one of the most encountered factors associated with death related to anesthesia. In the preoperative setting, the majority of antihypertensive medications should be continued until surgery. Only renin-angiotensin system antagonists may be stopped...
2014: Integrated Blood Pressure Control
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