journal
https://read.qxmd.com/read/38531873/associations-between-antipsychotics-induced-weight-gain-and-brain-networks-of-impulsivity
#1
JOURNAL ARTICLE
Claire Grosu, Paul Klauser, Daniella Dwir, Ines Khadimallah, Yasser Alemán-Gómez, Nermine Laaboub, Marianna Piras, Margot Fournier, Martin Preisig, Philippe Conus, Bogdan Draganski, Chin B Eap
Given the unpredictable rapid onset and ubiquitous consequences of weight gain induced by antipsychotics, there is a pressing need to get insights into the underlying processes at the brain system level that will allow stratification of "at risk" patients. The pathophysiological hypothesis at hand is focused on brain networks governing impulsivity that are modulated by neuro-inflammatory processes. To this aim, we investigated brain anatomy and functional connectivity in patients with early psychosis (median age: 23 years, IQR = 21-27) using anthropometric data and magnetic resonance imaging acquired one month to one year after initiation of AP medication...
March 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38531865/automated-mood-disorder-symptoms-monitoring-from-multivariate-time-series-sensory-data-getting-the-full-picture-beyond-a-single-number
#2
JOURNAL ARTICLE
Filippo Corponi, Bryan M Li, Gerard Anmella, Ariadna Mas, Isabella Pacchiarotti, Marc Valentí, Iria Grande, Antoni Benabarre, Marina Garriga, Eduard Vieta, Stephen M Lawrie, Heather C Whalley, Diego Hidalgo-Mazzei, Antonio Vergari
Mood disorders (MDs) are among the leading causes of disease burden worldwide. Limited specialized care availability remains a major bottleneck thus hindering pre-emptive interventions. MDs manifest with changes in mood, sleep, and motor activity, observable in ecological physiological recordings thanks to recent advances in wearable technology. Therefore, near-continuous and passive collection of physiological data from wearables in daily life, analyzable with machine learning (ML), could mitigate this problem, bringing MDs monitoring outside the clinician's office...
March 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38531856/alterations-in-subcortical-magnetic-susceptibility-and-disease-specific-relationship-with-brain-volume-in-major-depressive-disorder-and-schizophrenia
#3
JOURNAL ARTICLE
Shuhei Shibukawa, Hirohito Kan, Shiori Honda, Masataka Wada, Ryosuke Tarumi, Sakiko Tsugawa, Yui Tobari, Norihide Maikusa, Masaru Mimura, Hiroyuki Uchida, Yuko Nakamura, Shinichiro Nakajima, Yoshihiro Noda, Shinsuke Koike
Quantitative susceptibility mapping is a magnetic resonance imaging technique that measures brain tissues' magnetic susceptibility, including iron deposition and myelination. This study examines the relationship between subcortical volume and magnetic susceptibility and determines specific differences in these measures among patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls (HCs). This was a cross-sectional study. Sex- and age- matched patients with MDD (n = 49), patients with schizophrenia (n = 24), and HCs (n = 50) were included...
March 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38531835/identifying-plasma-metabolic-characteristics-of-major-depressive-disorder-bipolar-disorder-and-schizophrenia-in-adolescents
#4
JOURNAL ARTICLE
Bangmin Yin, Yuping Cai, Teng Teng, Xiaolin Wang, Xueer Liu, Xuemei Li, Jie Wang, Hongyan Wu, Yuqian He, Fandong Ren, Tianzhang Kou, Zheng-Jiang Zhu, Xinyu Zhou
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are classified as major mental disorders and together account for the second-highest global disease burden, and half of these patients experience symptom onset in adolescence. Several studies have reported both similar and unique features regarding the risk factors and clinical symptoms of these three disorders. However, it is still unclear whether these disorders have similar or unique metabolic characteristics in adolescents. We conducted a metabolomics analysis of plasma samples from adolescent healthy controls (HCs) and patients with MDD, BD, and SCZ...
March 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38531832/molecular-mechanisms-involved-in-alcohol-craving-irf3-and-endoplasmic-reticulum-stress-a-multi-omics-study
#5
JOURNAL ARTICLE
Ming-Fen Ho, Cheng Zhang, Irene Moon, Mustafa Tuncturk, Brandon J Coombes, Joanna Biernacka, Michelle Skime, Tyler S Oesterle, Victor M Karpyak, Hu Li, Richard Weinshilboum
Alcohol use disorder (AUD) is the most prevalent substance use disorder worldwide. Acamprosate and naltrexone are anti-craving drugs used in AUD pharmacotherapy. However, molecular mechanisms underlying their anti-craving effect remain unclear. This study utilized a patient-derived induced pluripotent stem cell (iPSC)-based model system and anti-craving drugs that are used to treat AUD as "molecular probes" to identify possible mechanisms associated with alcohol craving. We examined the pathophysiology of craving and anti-craving drugs by performing functional genomics studies using iPSC-derived astrocytes and next-generation sequencing...
March 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38521772/long-term-outcomes-of-physical-activity-counseling-in-in-patients-with-major-depressive-disorder-results-from-the-pacinpat-randomized-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Jan-Niklas Kreppke, Robyn Cody, Johannes Beck, Serge Brand, Lars Donath, Anne Eckert, Oliver Faude, Martin Hatzinger, Christian Imboden, Undine E Lang, Sebastian Ludyga, Sarah Mans, Thorsten Mikoteit, Anja Oswald, Nina Schweinfurth-Keck, Edith Holsboer-Trachsler, Lukas Zahner, Markus Gerber
Major depressive disorder (MDD) is an increasingly common psychiatric illness associated with a high risk of insufficient physical activity, which in turn is associated with negative mental and physical health outcomes. Theory-based, individually tailored, in-person and remote physical activity counseling has the potential to increase physical activity levels in various populations. Given this, the present study investigated the effect of such a physical activity intervention on the physical activity behavior of in-patients with MDD...
March 23, 2024: Translational Psychiatry
https://read.qxmd.com/read/38519470/exercise-intervention-in-middle-aged-and-elderly-individuals-with-insomnia-improves-sleep-and-restores-connectivity-in-the-motor-network
#7
JOURNAL ARTICLE
Rongrong Chen, Shilei Wang, Qinzi Hu, Ning Kang, Haijiang Xie, Meng Liu, Hongyu Shan, Yujie Long, Yizhe Hao, Bolin Qin, Hao Su, Yongchang Zhuang, Li Li, Weiju Li, Wei Sun, Dong Wu, Wentian Cao, Xiaoqin Mai, Gong Chen, Dongmin Wang, Qihong Zou
Exercise is a potential treatment to improve sleep quality in middle-aged and elderly individuals. Understanding exercise-induced changes in functional plasticity of brain circuits that underlie improvements in sleep among middle-aged and older adults can inform treatment of sleep problems. The aim of the study is to identify the effects of a 12-week exercise program on sleep quality and brain functional connectivity in middle-aged and older adults with insomnia. The trial was registered with Chinese Clinical Trial Register (ChiCTR2000033652)...
March 22, 2024: Translational Psychiatry
https://read.qxmd.com/read/38519465/interactions-between-neurotrophins-mood-and-physical-activity-under-the-conditions-of-sleep-deprivation
#8
JOURNAL ARTICLE
Marcin Sochal, Marta Ditmer, Agata Binienda, Aleksandra Tarasiuk, Piotr Białasiewicz, Szymon Turkiewicz, Filip Franciszek Karuga, Fichna Jakub, Agata Gabryelska
Sleep deprivation (DS) is the forced elimination of sleep. While brain-derived neurotrophic factor (BDNF) has been extensively studied in the context of in mood changes following DS, the role of other neurotrophins remains elusive. This study explores the impact of DS on BDNF, glial cell line-derived neurotrophic factor (GDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4) at mRNA and protein level, considering their potential links to mood disturbances. The study involved 81 participants subjected to polysomnography (PSG) and DS...
March 22, 2024: Translational Psychiatry
https://read.qxmd.com/read/38514652/depressive-symptoms-and-antidepressant-use-in-relation-to-white-blood-cell-count-among-postmenopausal-women-from-the-women-s-health-initiative
#9
JOURNAL ARTICLE
Hind A Beydoun, May A Beydoun, Sylvia Wassertheil-Smoller, Nazmus Saquib, JoAnn E Manson, Linda Snetselaar, Jordan Weiss, Alan B Zonderman, Robert Brunner
Inflammation can play a role in the pathophysiology of depression, and specific types of antidepressants may have inflammatory or anti-inflammatory properties. Furthermore, depression and antidepressant use has been linked to white blood cell (WBC) count, a routinely measured inflammatory marker. We examined the cross-sectional and longitudinal relationships of depressive symptoms and/or antidepressant use with WBC count among postmenopausal women. Analyses of cross-sectional data at enrollment were performed on 125,307 participants, 50-79 years of age, from the Women's Health Initiative Clinical Trials and Observational Studies who met eligibility criteria, and a subset of those with 3-year follow-up data were examined for longitudinal relationships...
March 21, 2024: Translational Psychiatry
https://read.qxmd.com/read/38509087/towards-a-scalable-approach-to-assess-speech-organization-across-the-psychosis-spectrum-online-assessment-in-conjunction-with-automated-transcription-and-extraction-of-speech-measures
#10
JOURNAL ARTICLE
Julianna Olah, Nicholas Cummins, Maite Arribas, Toni Gibbs-Dean, Elena Molina, Divina Sethi, Matthew J Kempton, Sarah Morgan, Tom Spencer, Kelly Diederen
Automatically extracted measures of speech constitute a promising marker of psychosis as disorganized speech is associated with psychotic symptoms and predictive of psychosis-onset. The potential of speech markers is, however, hampered by (i) lengthy assessments in laboratory settings and (ii) manual transcriptions. We investigated whether a short, scalable data collection (online) and processing (automated transcription) procedure would provide data of sufficient quality to extract previously validated speech measures...
March 21, 2024: Translational Psychiatry
https://read.qxmd.com/read/38509093/intranasal-delivery-of-shrna-to-knockdown-the-5ht-2a-receptor-enhances-memory-and-alleviates-anxiety
#11
JOURNAL ARTICLE
Troy T Rohn, Dean Radin, Tracy Brandmeyer, Peter G Seidler, Barry J Linder, Tom Lytle, John L Mee, Fabio Macciardi
Short-hairpin RNAs (shRNA), targeting knockdown of specific genes, hold enormous promise for precision-based therapeutics to treat numerous neurodegenerative disorders. However, whether shRNA constructed molecules can modify neuronal circuits underlying certain behaviors has not been explored. We designed shRNA to knockdown the human HTR2A gene in vitro using iPSC-differentiated neurons. Multi-electrode array (MEA) results showed that the knockdown of the 5HT-2A mRNA and receptor protein led to a decrease in spontaneous electrical activity...
March 20, 2024: Translational Psychiatry
https://read.qxmd.com/read/38509086/delay-of-punishment-highlights-differential-vulnerability-to-developing-addiction-like-behavior-toward-sweet-food
#12
JOURNAL ARTICLE
Marcello Solinas, Virginie Lardeux, Pierre-Marie Leblanc, Jean-Emmanuel Longueville, Nathalie Thiriet, Youna Vandaele, Leigh V Panlilio, Nematollah Jaafari
Resistance to punishment is commonly used to measure the difficulty in refraining from rewarding activities when negative consequences ensue, which is a hallmark of addictive behavior. We recently developed a progressive shock strength (PSS) procedure in which individual rats can titrate the amount of punishment that they are willing to tolerate to obtain food rewards. Here, we investigated the effects of a range of delays (0-12 s) on resistance to punishment measured by PSS break points. As expected from delay discounting principles, we found that delayed shock was less effective as a punisher, as revealed by higher PSS breakpoints...
March 20, 2024: Translational Psychiatry
https://read.qxmd.com/read/38504095/individualized-atomoxetine-response-and-tolerability-in-children-with-adhd-receiving-different-dosage-regimens-the-need-for-cyp2d6-genotyping-and-therapeutic-drug-monitoring-to-dance-together
#13
JOURNAL ARTICLE
Hong-Li Guo, Dan-Dan Wu, Di Fu, Yue Li, Jie Wang, Yuan-Yuan Zhang, Wei-Jun Wang, Jian Huang, Wei-Rong Fang, Jing Xu, Ya-Hui Hu, Qian-Qi Liu, Feng Chen
Integrating CYP2D6 genotyping and therapeutic drug monitoring (TDM) is crucial for guiding individualized atomoxetine therapy in children with attention-deficit/hyperactivity disorder (ADHD). The aim of this retrospective study was (1) to investigate the link between the efficacy and tolerability of atomoxetine in children with ADHD and plasma atomoxetine concentrations based on their CYP2D6 genotypes; (2) to offer TDM reference range recommendations for atomoxetine based on the CYP2D6 genotypes of children receiving different dosage regimens...
March 19, 2024: Translational Psychiatry
https://read.qxmd.com/read/38503761/post-traumatic-stress-disorder-in-a-national-sample-of-preadolescent-children-9-to-10-years-old-prevalence-correlates-clinical-sequelae-and-treatment-utilization
#14
JOURNAL ARTICLE
Rachel Y Levin, Richard T Liu
Although posttraumatic stress disorder (PTSD) has been well characterized in adults, its epidemiology in children is unclear. The current study provides the first population-based examination of the prevalence of PTSD, sociodemographic and psychiatric correlates, clinical sequelae, and associations with psychiatric treatment in preadolescents 9-10 years old in the United States. Data from the Adolescent Brain and Cognitive Development (ABCD) Study (release 5.0) was analyzed. Participants (unweighted n = 11,875) were recruited from 21 sites across the United States...
March 19, 2024: Translational Psychiatry
https://read.qxmd.com/read/38503740/cognitive-function-based-on-theta-gamma-coupling-vs-clinical-diagnosis-in-older-adults-with-mild-cognitive-impairment-with-or-without-major-depressive-disorder
#15
JOURNAL ARTICLE
Heather Brooks, Wei Wang, Reza Zomorrodi, Daniel M Blumberger, Christopher R Bowie, Zafiris J Daskalakis, Corinne E Fischer, Alastair J Flint, Nathan Herrmann, Sanjeev Kumar, Krista L Lanctôt, Linda Mah, Benoit H Mulsant, Bruce G Pollock, Aristotle N Voineskos, Tarek K Rajji
Whether individuals with mild cognitive impairment (MCI) and a history of major depressive disorder (MDD) are at a higher risk for cognitive decline than those with MCI alone is still not clear. Previous work suggests that a reduction in prefrontal cortical theta phase-gamma amplitude coupling (TGC) is an early marker of cognitive impairment. This study aimed to determine whether using a TGC cutoff is better at separating individuals with MCI or MCI with remitted MDD (MCI+rMDD) on cognitive performance than their clinical diagnosis...
March 19, 2024: Translational Psychiatry
https://read.qxmd.com/read/38499546/multimodal-digital-assessment-of-depression-with-actigraphy-and-app-in-hong-kong-chinese
#16
JOURNAL ARTICLE
Jie Chen, Ngan Yin Chan, Chun-Tung Li, Joey W Y Chan, Yaping Liu, Shirley Xin Li, Steven W H Chau, Kwong Sak Leung, Pheng-Ann Heng, Tatia M C Lee, Tim M H Li, Yun-Kwok Wing
There is an emerging potential for digital assessment of depression. In this study, Chinese patients with major depressive disorder (MDD) and controls underwent a week of multimodal measurement including actigraphy and app-based measures (D-MOMO) to record rest-activity, facial expression, voice, and mood states. Seven machine-learning models (Random Forest [RF], Logistic regression [LR], Support vector machine [SVM], K-Nearest Neighbors [KNN], Decision tree [DT], Naive Bayes [NB], and Artificial Neural Networks [ANN]) with leave-one-out cross-validation were applied to detect lifetime diagnosis of MDD and non-remission status...
March 18, 2024: Translational Psychiatry
https://read.qxmd.com/read/38493173/lateral-hypothalamus-orexinergic-projection-to-the-medial-prefrontal-cortex-modulates-chronic-stress-induced-anhedonia-but-not-anxiety-and-despair
#17
JOURNAL ARTICLE
Danlei Liu, Xuefeng Zheng, Yuqing Hui, Yuanyuan Xu, Jinjiang Du, Zean Du, Yichen Che, Fengming Wu, Guangyin Yu, Jifeng Zhang, Xiaobing Gong, Guoqing Guo
Chronic stress-induced anxiodepression is a common health problem, however its potential neurocircuitry mechanism remains unclear. We used behavioral, patch-clamp electrophysiology, chemogenetic, and optogenetic approaches to clarify the response of the lateral hypothalamus (LH) and the medial prefrontal cortex (mPFC) to stress, confirmed the structural connections between the LH and mPFC, and investigated the role of the LH-mPFC pathway in chronic stress-induced anxiodepression symptoms. Unpredictable chronic mild stress (UCMS) caused anxiodepression-like behaviors, including anxiety, anhedonia, and despair behaviors...
March 16, 2024: Translational Psychiatry
https://read.qxmd.com/read/38490997/rhesus-infant-nervous-temperament-predicts-peri-adolescent-central-amygdala-metabolism-behavioral-inhibition-measured-by-a-machine-learning-approach
#18
JOURNAL ARTICLE
D Holley, L J Campos, C M Drzewiecki, Y Zhang, J P Capitanio, A S Fox
Anxiety disorders affect millions of people worldwide and impair health, happiness, and productivity on a massive scale. Developmental research points to a connection between early-life behavioral inhibition and the eventual development of these disorders. Our group has previously shown that measures of behavioral inhibition in young rhesus monkeys (Macaca mulatta) predict anxiety-like behavior later in life. In recent years, clinical and basic researchers have implicated the central extended amygdala (EAc)-a neuroanatomical concept that includes the central nucleus of the amygdala (Ce) and the bed nucleus of the stria terminalis (BST)-as a key neural substrate for the expression of anxious and inhibited behavior...
March 15, 2024: Translational Psychiatry
https://read.qxmd.com/read/38485934/preliminary-evidence-for-preserved-synaptic-density-in-late-life-depression
#19
JOURNAL ARTICLE
Thomas Vande Casteele, Maarten Laroy, Margot Van Cauwenberge, Michel Koole, Patrick Dupont, Stefan Sunaert, Jan Van den Stock, Filip Bouckaert, Koen Van Laere, Louise Emsell, Mathieu Vandenbulcke
Late-life depression has been consistently associated with lower gray matter volume, the origin of which remains largely unexplained. Recent in-vivo PET findings in early-onset depression and Alzheimer's Disease suggest that synaptic deficits contribute to the pathophysiology of these disorders and may therefore contribute to lower gray matter volume in late-life depression. Here, we investigate synaptic density in vivo for the first time in late-life depression using the synaptic vesicle glycoprotein 2A receptor radioligand 11 C-UCB-J...
March 14, 2024: Translational Psychiatry
https://read.qxmd.com/read/38485930/resting-state-amygdala-subregion-and-precuneus-connectivity-provide-evidence-for-a-dimensional-approach-to-studying-social-anxiety-disorder
#20
JOURNAL ARTICLE
Simone Mizzi, Mangor Pedersen, Susan L Rossell, Peter Rendell, Gill Terrett, Markus Heinrichs, Izelle Labuschagne
Social anxiety disorder (SAD) is a prevalent and disabling mental health condition, characterized by excessive fear and anxiety in social situations. Resting-state functional magnetic resonance imaging (fMRI) paradigms have been increasingly used to understand the neurobiological underpinnings of SAD in the absence of threat-related stimuli. Previous studies have primarily focused on the role of the amygdala in SAD. However, the amygdala consists of functionally and structurally distinct subregions, and recent studies have highlighted the importance of investigating the role of these subregions independently...
March 14, 2024: Translational Psychiatry
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