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Cell & Bioscience

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https://www.readbyqxmd.com/read/29142737/cloning-expression-and-identification-of-ktx-sp4-a-selective-kv1-3-peptidic-blocker-from-scorpiops-pococki
#1
Yan Zou, Feng Zhang, Yaxian Li, Yuanfang Wang, Yi Li, Zhengtao Long, Shujuan Shi, Li Shuai, Jiukai Liu, Zhiyong Di, Shijin Yin
Background: Specific and selective peptidic blockers of Kv1.3 channels can serve as a valuable drug lead for treating T cell-mediated autoimmune diseases, and scorpion venom is an important source of kv1.3 channel inhibitors. Through conducting transcriptomic sequencing for the venom gland of Scorpiops pococki from Xizang province of China, this research aims to discover a novel functional gene encoding peptidic blocker of Kv1.3, and identify its function. Results: We screened out a new peptide toxin KTX-Sp4 which had 43 amino acids including six cysteine residues...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29142736/strain-differences-in-cuprizone-induced-demyelination
#2
Qili Yu, Ryan Hui, Jiyoung Park, Yangyang Huang, Alexander W Kusnecov, Cheryl F Dreyfus, Renping Zhou
Background: Multiple sclerosis (MS) is a severe neurological disorder, characterized by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people worldwide. In terms of research in MS pathology, the cuprizone toxicity model is widely used. Here we investigated the contribution of genetic differences in response to cuprizone-induced demyelination in two genetically different mouse strains: CD1 and C57BL/6. Results: We demonstrate that exposure to a diet containing 0...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29118970/14-3-3%C3%AE-loss-leads-to-neonatal-lethality-by-microrna-126-downregulation-mediated-developmental-defects-in-lung-vasculature
#3
Jun Yang, Sonali Joshi, Qingfei Wang, Ping Li, Hai Wang, Yan Xiong, Yi Xiao, Jinyang Wang, Jan Parker-Thornburg, Richard R Behringer, Dihua Yu
Background: The 14-3-3 family of proteins have been reported to play an important role in development in various mouse models, but the context specific developmental functions of 14-3-3ζ remain to be determined. In this study, we identified a context specific developmental function of 14-3-3ζ. Results: Targeted deletion of 14-3-3ζ in the C57Bl/6J murine genetic background led to neonatal lethality due to respiratory distress and could be rescued by out-breeding to the CD-1 or backcrossing to the FVB/NJ congenic background...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29118969/differential-regulation-of-ifn%C3%AE-ifn%C3%AE-and-ifn%C3%AE%C2%B5-gene-expression-in-human-cervical-epithelial-cells
#4
Jennifer Couret, Carley Tasker, Jaeha Kim, Tiina Sihvonen, Saahil Fruitwala, Alison J Quayle, Pierre Lespinasse, Debra S Heller, Theresa L Chang
Interferonε (IFNε) is a unique type I IFN that has distinct functions from IFNα/β. IFNε is constitutively expressed at mucosal tissues, including the female genital mucosa, and is reported to be modulated by estrogen and seminal plasma. However, its regulation by cytokines, including TNFα, IL-1β, IL-6, IL-8, IL-17, IL-22 and IFNα, which are commonly present in the female genital mucosa, is not well documented in freshly isolated primary cervical cells from tissues. We determined the effect of these cytokines on gene expression of type I IFNs in an immortalized endocervical epithelial cell line (A2EN) and in primary cervical epithelial cells...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29118968/combination-of-ezh2-inhibitor-and-bet-inhibitor-for-treatment-of-diffuse-intrinsic-pontine-glioma
#5
Yaqin Zhang, Weijie Dong, Junying Zhu, Lizhu Wang, Xinjian Wu, Hong Shan
Background: Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically improvement of patient's condition, however, the tumor recurs rapidly. More and more studies are focused on the genetic and epigenetic drivers of DIPGs, which may provide more and more novel therapy target for DIPG. EZH2 has been proved to be a potential therapeutic target for H3K27M-mutant pediatric gliomas recently...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29090089/sirtinol-regulates-the-balance-of-th17-treg-to-prevent-allograft-rejection
#6
Qing Ye, Mingjian Zhang, Yang Wang, Shangxi Fu, Shu Han, Liming Wang, Quanxing Wang
BACKGROUND: Current immunosuppressive medications used after transplantation induce significant toxicity , and a new medication regimen is needed. Based on recent research, Sirt1 exerts a proinflammatory effect on the immune response. Sirtinol is a Sirt1 inhibitor, but its impact on allograft rejection and its molecular mechanisms of action have not yet been reported. RESLUTS: In this study, we examined the effect of sirtinol on prolonging allograft survival in a mouse cervical heterotopic heart transplantation model...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29090088/gut-microbiota-as-a-potential-target-of-metabolic-syndrome-the-role-of-probiotics-and-prebiotics
#7
REVIEW
Mingqian He, Bingyin Shi
Metabolic syndrome (MS) comprises central obesity, increased plasma glucose levels, hyperlipidemia and hypertension, and its incidence is increasing due to changes in lifestyle and dietary structure in recent years. MS has been proven to be associated with an increased incidence of cardiovascular diseases and type 2 diabetes mellitus, leading to morbidity and mortality. In this manuscript, we review recent studies concerning the role of the gut microbiota in MS modulation. Manipulation of the gut microbiota through the administration of prebiotics or probiotics may assist in weight loss and reduce plasma glucose and serum lipid levels, decreasing the incidence of cardiovascular diseases and type 2 diabetes mellitus...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29075436/the-expanding-functions-of-thyroid-hormone
#8
EDITORIAL
Jiemin Wong, Shaochung Victor Hsia
No abstract text is available yet for this article.
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29051813/differential-impact-of-various-reactive-oxygen-species-ros-on-hif-1%C3%AE-p53-direct-interaction-in-sk-n-mc-neuroblastoma-cells
#9
Elham Parandavar, Razieh Yazdanparast
BACKGROUND: A vital property of eukaryotic cells physiology is their rather quick response to variation of oxygen tension, mainly by a transcription factor known as hypoxia-inducible factor-1 (HIF-1). Aside from its transcriptional regulation, other mechanisms, such as post translational modifications and protein-protein interactions, the interaction between HIF-1α and p53 has attracted more attention mainly due to simultaneous enhancement in the protein levels of these two anti- and pro-apoptotic vital transcriptional factors within the ROS-stressed cells...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29043013/mir-125a-suppresses-viability-and-glycolysis-and-induces-apoptosis-by-targeting-hexokinase-2-in-laryngeal-squamous-cell-carcinoma
#10
Zhanwei Sun, Wenqi Zhang, Qian Li
BACKGROUND: miR-125a usually functions as a tumor suppressor in cancers. However, the role of miR-125a in laryngeal squamous cell carcinoma (LSCC) has not been determined. METHODS: qRT-PCR was applied to measure the expression of miR-125a and HK2 mRNA in LSCC tissues and cells. CCK-8 kit and flow cytometry analysis were performed to detect cell viability and apoptosis. Luciferase reporter assay and RNA immunoprecipitation (RIP) were conducted to confirm the relationship between miR-125a and HK2...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29034071/apigenin-in-cancer-therapy-anti-cancer-effects-and-mechanisms-of-action
#11
REVIEW
Xiaohui Yan, Miao Qi, Pengfei Li, Yihong Zhan, Huanjie Shao
Apigenin is a common dietary flavonoid that is abundantly present in many fruits, vegetables and Chinese medicinal herbs and serves multiple physiological functions, such as strong anti-inflammatory, antioxidant, antibacterial and antiviral activities and blood pressure reduction. Therefore, apigenin has been used as a traditional medicine for centuries. Recently, apigenin has been widely investigated for its anti-cancer activities and low toxicity. Apigenin was reported to suppress various human cancers in vitro and in vivo by multiple biological effects, such as triggering cell apoptosis and autophagy, inducing cell cycle arrest, suppressing cell migration and invasion, and stimulating an immune response...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29021892/catching-global-interactions-in-vivo
#12
Yi Qiu, Suming Huang
Histone proteins and transcription factors (TFs) play critical roles in gene transcription and development of multicellular organisms. Although antibody mediated protein isolation couple with mass spectrometry approach has been a standard method to identify TF interacting partners and characterize their functional molecular complexes, it becomes urge to develop a robust method to functional characterize how these transcription factors act during biological process in the post-human genome project era. Here, Dr...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29021891/a-good-sugar-d-mannose-suppresses-autoimmune-diabetes
#13
Yun-Bo Shi, Deling Yin
It is well known that too much sugar uptake causes many health problems, including diabetes and obesity (Lustig et al. in Nature 482:27-29, 2012). However, a team of researchers led by Dr. Wanjun Chen of the National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), USA, have recently shown that d-mannose, a naturally occurring C-2 epimer of glucose is likely beneficial to human health. Their studies have revealed that supraphysiological levels of d-mannose that are safely achievable via drinking-water supplementation can be preventive and therapeutic to experimental autoimmune diabetes and asthmatic lung inflammation (Zhang et al...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28904745/genome-editing-of-the-hiv-co-receptors-ccr5-and-cxcr4-by-crispr-cas9-protects-cd4-t-cells-from-hiv-1-infection
#14
Zhepeng Liu, Shuliang Chen, Xu Jin, Qiankun Wang, Kongxiang Yang, Chenlin Li, Qiaoqiao Xiao, Panpan Hou, Shuai Liu, Shaoshuai Wu, Wei Hou, Yong Xiong, Chunyan Kong, Xixian Zhao, Li Wu, Chunmei Li, Guihong Sun, Deyin Guo
BACKGROUND: The main approach to treat HIV-1 infection is combination antiretroviral therapy (cART). Although cART is effective in reducing HIV-1 viral load and controlling disease progression, it has many side effects, and is expensive for HIV-1 infected patients who must remain on lifetime treatment. HIV-1 gene therapy has drawn much attention as studies of genome editing tools have progressed. For example, zinc finger nucleases (ZFN), transcription activator like effector nucleases (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 have been utilized to successfully disrupt the HIV-1 co-receptors CCR5 or CXCR4, thereby restricting HIV-1 infection...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28852471/enhancing-antitumor-immunogenicity-of-hpv16-e7-dna-vaccine-by-fusing-dna-encoding-e7-antigenic-peptide-to-dna-encoding-capsid-protein-l1-of-bovine-papillomavirus
#15
Andrew Yang, Shiwen Peng, Emily Farmer, Qi Zeng, Max A Cheng, Xiaowu Pang, T-C Wu, Chien-Fu Hung
BACKGROUND: Human papillomavirus (HPV) has been identified as the primary etiologic factor of cervical cancer, the fourth leading cause of cancer death in females worldwide. We have previously shown that coadministration of DNA encoding L1 capsid protein of Bovine papillomavirus (BPV) can enhance the antigen-specific immune response elicited by a therapeutic HPV16-E7 DNA vaccination. In this study, we sought to generate and evaluate the immunogenicity of a therapeutic HPV16-E7 DNA vaccine that encodes the fusion construct of HPV16-E7 and BPV-L1...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28852470/investigation-of-host-pathogen-interaction-between-burkholderia-pseudomallei-and-autophagy-related-protein-lc3-using-hydrophobic-chromatography-based-technique
#16
Pattamaporn Joompa, Saranyoo Ponnikorn, Sittiruk Roytrakul, Sumalee Tungpradabkul
BACKGROUND: Burkholderia pseudomallei is an intracellular bacteria causing Melioidosis, the disease widely disseminates in Southeast Asia and Northern Australia. B. pseudomallei has ability to invade various types of host cell and to interfere with host defense mechanisms, such as nitric oxide (NO). Due to the cross-talk among alternative killing mechanisms in host immune response against invading microbes, autophagy is the molecular mechanism belonging to intracellular elimination of eukaryotic cells that has been widely discussed...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28852469/ginkgetin-aglycone-ameliorates-lps-induced-acute-kidney-injury-by-activating-sirt1-via-inhibiting-the-nf-%C3%AE%C2%BAb-signaling-pathway
#17
Junwei Zhang, Suxia Yang, Fang Chen, Huicong Li, Baoping Chen
BACKGROUND: Ginkgetin aglycone (GA), a novel Ginkgo biloba extract (GBE) by acid hydrolysis and recrystallization, is characterized by higher liposolubility and antioxidation than classical GBEs. There is no study depicting the functional role of GA in acute kidney injury (AKI). Here, we firstly reported the protective effect of GA on lipopolysaccharide (LPS)-induced AKI and its underlying mechanism. METHODS: ELISA analysis was applied to measure plasma level of TNF-α and IL-6, and NF-κB activity in kidney homogenate...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28852468/phosphorylation-of-astrocytic-connexin43-by-erk1-2-impairs-blood-brain-barrier-in-acute-cerebral-ischemia
#18
Wei Chen, Jiugeng Feng, Wusong Tong
BACKGROUND: Connexins are a family of transmembrane proteins that form gap junctions, which are important for diffusion of cytosolic factors such as ions and second messenger signaling molecules. Our previous study has shown that Connexin40 (Cx40), one dominant connexin expressed in brain, was involved in brain injury. In this study, Cx43, another dominant connexin in brain, was investigated. Using bilateral common carotid artery occlusion-induced ischemia rat model, we tested the expression and phosphorylation level of Cx43 as well as heteromeric Cx40/Cx43 complex formation in brain after ischemia induction...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28815013/diabetic-retinopathy-reversibility-of-epigenetic-modifications-and-new-therapeutic-targets
#19
REVIEW
Xinyuan Zhang, Lin Zhao, Brett Hambly, Shisan Bao, Kaiyue Wang
In recent years, considerable progress has been made in the molecular mechanisms of epigenetics in disease development and progression, the reversible characteristics of epigenetic modification provide new insights for the treatment of such diseases. The pathogenesis of diabetic retinopathy (DR) has not yet been fully understood, treatment of refractory and recurrent diabetic macular edema remains a big change in clinical practice. This review emphasizes that reversibility of epigenetic modification could provide a new strategy for the prevention and treatment of diseases...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28815012/the-2016-ming-k-jeang-award-for-excellence-in-cell-bioscience
#20
EDITORIAL
Yun-Bo Shi
Two research groups led by Dr. Jim Hu of University of Toronto, Canada and Dr. Renping Zhou of Rutgers University, USA, respectively, won the 2016 Ming K Jeang Award for Excellence in Cell & Bioscience.
2017: Cell & Bioscience
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