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Cell & Bioscience

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https://www.readbyqxmd.com/read/30651971/il-33-ameliorates-experimental-colitis-involving-regulation-of-autophagy-of-macrophages-in-mice
#1
Zhongyan Wang, Lifeng Shi, Shuyao Hua, Chang Qi, Min Fang
Background: Previously, we have demonstrated that IL-33 administration protecting TNBS-induced experimental colitis is associated with facilitation of Th2/Tregs responses in mice. However, whether IL-33 regulates autophagy to ameliorate experimental colitis is unclear. Results: IL-33 administration (2 μg/day, intraperitoneal injection), while facilitating Th2/Tregs responses, also enhances the autophagy in mice with TNBS-induced colitis as well as macrophages...
2019: Cell & Bioscience
https://www.readbyqxmd.com/read/30651970/transmembrane-protein-108-involves-in-adult-neurogenesis-in-the-hippocampal-dentate-gyrus
#2
Zheng Yu, Dong Lin, Yanzi Zhong, Bin Luo, Shengsheng Liu, Erkang Fei, Xinsheng Lai, Suqi Zou, Shunqi Wang
Background: Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown. Results: Here we investigated the pathophysiological function of Tmem108 in the hippocampal dentate gyrus by using Tmem108 mutant mice. Tmem108 highly expressed in the dentate gyrus and CA3 of the hippocampus. Dentate gyrus is a brain region where adult neurogenesis occurs, and aberrant adult neurogenesis in dentate gyrus has been implicated in major depression disorder...
2019: Cell & Bioscience
https://www.readbyqxmd.com/read/30637096/dynamics-expression-of-dmfkbp12-calstabin-during-embryonic-early-development-of-drosophila-melanogaster
#3
Rui Feng, Xin Zhou, Wei Zhang, Tao Pu, Yuting Sun, Rong Yang, Dan Wang, Xiaofei Zhang, Yingfeng Gao, Zhenlu Cai, Yu Liang, Qiuxia Yu, Yajun Wu, Xinjuan Lei, Zhijia Liang, Odell Jones, Liyang Wang, Mengmeng Xu, Yanping Sun, William B Isaacs, Jianjie Ma, Xuehong Xu
Background: Calcium signaling are conserved from invertebrates to vertebrates and plays critical roles in many molecular mechanisms of embryogenesis and postnatal development. As a critical component of the signaling pathway, the RyR medicated calcium-induced calcium release signaling system, has been well studied along with their regulator FK506-binding protein 12 (FKBP12/Calstabin). Lack of FKBP12 is known to result in lethal cardiac dysfunction in mouse. However, precisely how FKBP12 is regulated and effects calcium signaling in Drosophila melanogaster remains largely unknown...
2019: Cell & Bioscience
https://www.readbyqxmd.com/read/30627420/a-prospect-of-cell-immortalization-combined-with-matrix-microenvironmental-optimization-strategy-for-tissue-engineering-and-regeneration
#4
REVIEW
Yiming Wang, Song Chen, Zuoqin Yan, Ming Pei
Cellular senescence is a major hurdle for primary cell-based tissue engineering and regenerative medicine. Telomere erosion, oxidative stress, the expression of oncogenes and the loss of tumor suppressor genes all may account for the cellular senescence process with the involvement of various signaling pathways. To establish immortalized cell lines for research and clinical use, strategies have been applied including internal genomic or external matrix microenvironment modification. Considering the potential risks of malignant transformation and tumorigenesis of genetic manipulation, environmental modification methods, especially the decellularized cell-deposited extracellular matrix (dECM)-based preconditioning strategy, appear to be promising for tissue engineering-aimed cell immortalization...
2019: Cell & Bioscience
https://www.readbyqxmd.com/read/30627419/xpd-suppresses-cell-proliferation-and-migration-via-mir-29a-3p-mdm2-pdgf-b-axis-in-hcc
#5
Zhihua Xiao, Yijun Wang, Hao Ding
Objective: The aim of this study was to investigate the role of XPD in migration and invasion of hepatocellular carcinoma (HCC) cells. Methods: The expression of XPD and miR-29a-3p was examined by western blot and qRT-PCR, cell proliferation was detected by MTT assay, cell migration was detected by transwell assay. TargetScan was used to predict potential targets of miR-29a-3p. Results: In this study, we found that the expression of XPD and miR-29a-3p was downregulated in HCC samples and HCC cell lines...
2019: Cell & Bioscience
https://www.readbyqxmd.com/read/30622699/cell-type-specific-function-of-traf2-and-traf3-in-regulating-type-i-ifn-induction
#6
Xiaoping Xie, Jin Jin, Lele Zhu, Zuliang Jie, Yanchuan Li, Baoyu Zhao, Xuhong Cheng, Pingwei Li, Shao-Cong Sun
Background: TRAF3 is known as a central mediator of type I interferon (IFN) induction by various pattern recognition receptors, but the in vivo function of TRAF3 in host defense against viral infection is poorly defined due to the lack of a viable mouse model. Results: Here we show that mice carrying conditional deletion of TRAF3 in myeloid cells or dendritic cells do not have a significant defect in host defense against vesicular stomatitis virus (VSV) infection...
2019: Cell & Bioscience
https://www.readbyqxmd.com/read/30622698/1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol-plag-attenuates-gemcitabine-induced-neutrophil-extravasation
#7
Jinseon Jeong, Yong-Jae Kim, Do Young Lee, Byoung-Gon Moon, Ki-Young Sohn, Sun Young Yoon, Jae Wha Kim
Cancer patients treated with chemotherapy often experience a rapid decline of blood neutrophils, a dose-limiting side effect called chemotherapy-induced neutropenia. This complication brings about dose reductions or cessation of chemotherapy during treatment of cancer patients because a rapid decline of neutrophil counts increases susceptibility to infection. Here, we found that 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) attenuates gemcitabine-induced neutrophil extravasation via the inhibition of neutrophil-attracting chemokine production in macrophages using in vivo and in vitro approaches...
2019: Cell & Bioscience
https://www.readbyqxmd.com/read/30622697/stat3-enhances-the-constitutive-activity-of-agc-kinases-in-melanoma-by-transactivating-pdk1
#8
María Elisa Picco, María Victoria Castro, María Josefina Quezada, Gastón Barbero, María Belén Villanueva, Natalia Brenda Fernández, Hyungsoo Kim, Pablo Lopez-Bergami
Background: The PI3K/Akt and the STAT3 pathways are functionally associated in many tumor types. Both in vitro and in vivo studies have revealed that either biochemical or genetic manipulation of the STAT3 pathway activity induce changes in the same direction in Akt activity. However, the implicated mechanism has been poorly characterized. Our goal was to characterize the precise mechanism linking STAT3 with the activity of Akt and other AGC kinases in cancer using melanoma cells as a model...
2019: Cell & Bioscience
https://www.readbyqxmd.com/read/30622696/the-first-structure-of-hiv-1-gp120-with-cd4-and-ccr5-receptors
#9
Yongjun Guan
Shaik et al. recently published online the cryo-electron microscopy structure of HIV-1 gp120 in complex with CD4 and CCR5 receptors. This is the first structure of the ternary HIV-1 gp120/CD4/CCR5 complex. This breakthrough of Env structure provides insights into HIV-1 fusion mechanism, CCR5 function, co-receptor switch, and, most importantly, the development of co-receptor-targeted therapeutic inhibitor and HIV-1 vaccine. It also shed lights on the immunogenicity of gp120 by revealing the stably exposed conserved gp41-interactive region of gp120 in the complex...
2019: Cell & Bioscience
https://www.readbyqxmd.com/read/30622695/exosomes-from-hyperglycemia-stimulated-vascular-endothelial-cells-contain-versican-that-regulate-calcification-senescence-in-vascular-smooth-muscle-cells
#10
Shuang Li, Jun-Kun Zhan, Yan-Jiao Wang, Xiao Lin, Jia-Yu Zhong, Yi Wang, Pan Tan, Jie-Yu He, Xing-Jun Cui, Yi-Yin Chen, Wu Huang, You-Shuo Liu
Background: To determine whether and how exosomes from human umbilical vein endothelial cells (HUVEC-Exos) regulates vascular smooth muscle cells (VSMCs) calcification/senescence in high glucose condition. Methods: HUVEC-Exos were isolated from normal glucose (NG) and high glucose (HG) stimulated HUVECs (NG/HG-HUVEC-Exos) by super speed centrifugation. HUVEC-Exos were identified by transmission electron microscopy and Western blot of CD63. Protein profile in HUVEC-Exos was examined to screen the candidate molecules that mediate HUVEC-Exos function...
2019: Cell & Bioscience
https://www.readbyqxmd.com/read/30555678/polysialic-acid-is-released-by-human-umbilical-vein-endothelial-cells-huvec-in-vitro
#11
Sebastian Strubl, Uwe Schubert, Andrea Kühnle, Alexander Rebl, Negah Ahmadvand, Silvia Fischer, Klaus T Preissner, Sebastian P Galuska
Background: Sialic acids represent common terminal residues on numerous mammalian glycoconjugates, thereby influencing e.g. lumen formation in developing blood vessels. Interestingly, besides monosialylated also polysialylated glycoconjugates are produced by endothelial cells. Polysialic acid (polySia) is formed in several organs during embryonal and postnatal development influencing, for instance, cell migration processes. Furthermore, the function of cytokines like basic fibroblast growth factor (bFGF) is modulated by polySia...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/30534359/the-roles-of-lncrna-in-hepatic-fibrosis
#12
REVIEW
Hu Peng, Lin-Yan Wan, Jia-Jie Liang, Yan-Qiong Zhang, Wen-Bing Ai, Jiang-Feng Wu
Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate gene or protein expression; however, their function in the progression of hepatic fibrosis remains unclear. Hepatic fibrosis is a continuous wound-healing process caused by numerous chronic hepatic diseases, and the activation of hepatic stellate cells (HSCs) is generally considered to be a pivotal step in hepatic fibrosis. In the process of hepatic fibrosis, some lncRNAs regulates diverse cellular processes. Here are several examples: the lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and liver fibrosis-associated lncRNA1 (lnc-LFAR1) promote HSC activation in the progression of hepatic fibrosis via the transforming growth factor-β signaling pathway; the lncRNA HIF 1 alpha-antisense RNA 1 (HIF1A-AS1) and Maternally expressed gene 3 reduce HSC activation which are associated with DNA methylation; the lncRNA plasmacytoma variant translocation 1, Homeobox (HOX) transcript antisense RNA and MALAT1 promote HSC activation as competing endogenous RNAs (ceRNAs); the long intergenic non-coding RNA-p21 (lncRNA-p21) and Growth arrest-specific transcript 5 reduce HSC activation as ceRNAs...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/30534358/tipe2-acts-as-a-biomarker-for-gist-risk-category-and-suppresses-the-viability-and-invasiveness-of-gist-cells
#13
Zequn Li, Wei Zhang, Yi Li, Shougen Cao, Shanglong Liu, Liang Ning, Xuelong Jiao, Zimin Liu, Xiaoming Xing, Yujun Li, Yanbing Zhou
Evaluating the risk category of gastrointestinal stromal tumors (GISTs) is crucial for predicting prognosis and choosing treatment strategies, and tumor metastasis usually represent poor prognosis. Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) is a novel described tumor suppressor. In the present study, TIPE2 expression was detected using a total of 96 human GIST specimens by immunohistochemistry. The effect of TIPE2 on proliferation and invasiveness of GIST cells and its related mechanisms were explored in vitro...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/30519392/tug1-confers-cisplatin-resistance-in-esophageal-squamous-cell-carcinoma-by-epigenetically-suppressing-pdcd4-expression-via-ezh2
#14
Caihui Xu, Yinmou Guo, Haiyan Liu, Gongbin Chen, Yanju Yan, Teng Liu
Background: Increasing evidence has suggested the involvement of long non-coding RNA taurine upregulated gene 1 (TUG1) in chemoresistance of cancer treatment. However, its function and molecular mechanisms in esophageal squamous cell carcinoma (ESCC) chemoresistance are still not well elucidated. In the present study, we investigate the functional role of TUG1 in cisplatin (DDP) resistance of ESCC and discover the underlying molecular mechanism. Results: Our study revealed that TUG1 was up-regulated in DDP-resistant ESCC tissues and cells...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/30479742/-jq1-attenuated-lps-induced-microglial-inflammation-via-mapk-nf%C3%AE%C2%BAb-signaling
#15
Huanhuan Wang, Wenhai Huang, Meihao Liang, Yingying Shi, Chixiao Zhang, Qin Li, Meng Liu, Yikai Shou, Hongping Yin, Xiaozheng Zhu, Xiaoyan Sun, Yu Hu, Zhengrong Shen
Background: Microglia activation is a crucial event in neurodegenerative disease. The depression of microglial inflammatory response is considered a promising therapeutic strategy. NFκB signaling, including IKK/IκB phosphotylation, p65 nucelus relocalization and NFκB-related genes transcription are prevalent accepted to play important role in microglial activation. (+)-JQ1, a BRD4 inhibitor firstly discovered as an anti-tumor agent, was later confirmed to be an anti-inflammatory compound...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/30459943/class-2-crispr-cas-an-expanding-biotechnology-toolbox-for-and-beyond-genome-editing
#16
REVIEW
Yuyi Tang, Yan Fu
Artificial nuclease-dependent DNA cleavage systems (zinc-finger nuclease, ZFN; transcription activator like effectors, TALENs) and exogenous nucleic acid defense systems (CRISPR/Cas) have been used in the new era for genome modification. The most widely used toolbox for genome editing, modulation and detection contains Types II, V and VI of CRISPR/Cas Class 2 systems, categorized and characterized by Cas9, Cas12a and Cas13 respectively. In this review, we (1) elaborate on the definition, classification, structures of CRISPR/Cas Class 2 systems; (2) advance our understanding of new molecular mechanisms and recent progress in their applications, especially beyond genome-editing applications; (3) provide the insights on the specificity, efficiency and versatility of each tool; (4) elaborate the enhancement on specificity and efficiency of the CRISPR/Cas toolbox...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/30450190/cited1-promotes-proliferation-of-papillary-thyroid-cancer-cells-via-the-regulation-of-p21-and-p27
#17
Hai Li, Hongyu Guan, Yan Guo, Weiwei Liang, Liehua Liu, Xiaoying He, Weijian Ke, Xiaopei Cao, Haipeng Xiao, Yanbing Li
Background: It has been reported that CBP/p300-Interacting Transactivator with glutamic acid [E]/aspartic acid [D]-rich C-terminal domain 1 (CITED1) is overexpressed in papillary thyroid cancer (PTC). However, the functional significance and underlying mechanisms of CITED1 in PTC are largely unknown. Methods: The Cancer Genome Atlas dataset and real-time PCR were used to determine the expression of CITED1 in PTC. The role of CITED1 in PTC cell proliferation was determined conducted using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), colony formation, 5-ethynyl-2'-deoxyuridine (EdU) incorporation, and flow cytometry assays in vitro, and a subcutaneous xenotransplantation tumor model in nude mice was established to analyze tumor growth in vivo...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/30410722/circ_0027599-phdla1-suppresses-gastric-cancer-progression-by-sponging-mir-101-3p-1
#18
Liang Wang, Jingyan Shen, Yushan Jiang
Background: Pleckstrin homology-like domain family A member 1 (PHLDA1) is a tumor suppressor gene in gastric cancer, but its role regulated by circular RNAs (circRNAs) is not known. CircRNAs are important regulators in cancer growth and progression, however, the molecular roles of circRNAs in gastric cancer are rarely known. The study was aimed to investigate the role of circRNAs in regulating PHLDA1 expression in gastric cancer. Results: The circRNA expression profile in the gastric cancer tissues by circRNA microarray showed that hsa_circ_0027599 (circ_0027599) was significantly down-regulated in gastric cancer patients and cells when comparing with the controls...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/30410721/essential-roles-of-mitochondrial-and-heme-function-in-lung-cancer-bioenergetics-and-tumorigenesis
#19
REVIEW
Sarada Preeta Kalainayakan, Keely E FitzGerald, Purna Chaitanya Konduri, Chantal Vidal, Li Zhang
Contrary to Warburg's hypothesis, mitochondrial oxidative phosphorylation (OXPHOS) contributes significantly to fueling cancer cells. Several recent studies have demonstrated that radiotherapy-resistant and chemotherapy-resistant cancer cells depend on OXPHOS for survival and progression. Several cancers exhibit an increased risk in association with heme intake. Mitochondria are widely known to carry out oxidative phosphorylation. In addition, mitochondria are also involved in heme synthesis. Heme serves as a prosthetic group for several proteins that constitute the complexes of mitochondrial electron transport chain...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/30386554/microrna-29a-3p-enhances-dental-implant-osseointegration-of-hyperlipidemic-rats-via-suppressing-dishevelled-2-and-frizzled-4
#20
Fei Liu, Zhifeng Wang, Fangfang Liu, Jinzhao Xu, Qibo Liu, Kaifeng Yin, Jing Lan
Background: Fine osseointegration is the basis of long-term survival of implant. In our previous study, we observed a strong correlation between hyperlipidemia and compromised osseointegration. MicroRNA-29a-3p (miR-29a-3p) has been discovered to participate in bone marrow mesenchymal stem cells (BMSCs) differentiation. However, the role and the underlying mechanisms of hyperlipidemia and miR-29a-3p in osseointegration still remain obscure. Results: In peri-implant bone tissues of hyperlipidemia rats, bone mass, mineralization and bone trabecula formation were weakened...
2018: Cell & Bioscience
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