journal
MENU ▼
Read by QxMD icon Read
search

Cell & Bioscience

journal
https://www.readbyqxmd.com/read/29760876/rinck-mediated-monoubiquitination-of-cgas-promotes-antiviral-innate-immune-responses
#1
Zhao-Shan Liu, Zi-Yu Zhang, Hong Cai, Ming Zhao, Jie Mao, Jiang Dai, Tian Xia, Xue-Min Zhang, Tao Li
Background: As an important danger signal, the presence of DNA in cytoplasm triggers potent immune responses. Cyclic GMP-AMP synthase (cGAS) is a recently characterized key sensor for cytoplasmic DNA. The engagement of cGAS with DNA leads to the synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which binds and activates the downstream adaptor protein STING to promote type I interferon production. Although cGAS has been shown to play a pivotal role in innate immunity, the exact regulation of cGAS activation is not fully understood...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29744030/tumor-cells-versus-host-immune-cells-whose-pd-l1-contributes-to-pd-1-pd-l1-blockade-mediated-cancer-immunotherapy
#2
Fei Tang, Pan Zheng
Antibody blockade of the PD-1/PD-L1 pathway has elicited durable antitumor responses in the therapy of a broad spectrum of cancers. PD-L1 is constitutively expressed in certain tumors and host immune cells, and its expression can be induced or maintained by many factors. The expression of PD-L1 on tumor tissues has been reported to be positively correlated with the efficacy of anti-PD-1/PD-L1 therapy in patients. However, multiple clinical trials indicate that patients with PD-L1-negative tumors also respond to this blockade therapy, which suggests the potential contribution of PD-L1 from host immune cells...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29736233/nos2-deficiency-has-no-influence-on-the-radiosensitivity-of-the-hematopoietic-system
#3
Chengcheng Li, Yi Luo, Lijian Shao, Aimin Meng, Daohong Zhou
Objective: Previous studies have shown that inhibition of inducible NO synthase (NOS2 or iNOS) with an inhibitor can selectively protect several normal tissues against radiation during radiotherapy. However, the role of NOS2 in ionizing radiation (IR)-induced bone marrow (BM) suppression is unknown and thus was investigated in the present study using NOS2- /- and wild-type mice 14 days after they were exposed to a sublethal dose of total body irradiation (TBI). Methods: The effects of different doses of IR (1, 2 and 4 Gy) on the apoptosis and colony-forming ability of bone marrow cells from wild-type (WT) and NOS2- /- mice were investigated in vitro...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29713455/cardiac-regeneration-in-xenopus-tropicalis-and-xenopus-laevis-discrepancies-and-problems
#4
Souqi Liao, Wenyan Dong, Hui Zhao, Ruijin Huang, Xufeng Qi, Dongqing Cai
Two studies have recently focused on adult heart regeneration in Xenopus . While we reported on cardiac myogenic regeneration in Xenopus tropicalis after injury, Marshall and colleagues found no regeneration in an injured heart in Xenopus laevis. Here, we would like to join the discussion initiated by Marshall et al. who debated the methods and species differences in both studies. We agree with their view that the species difference in cardiac regenerative capacity could lead to different results in both of these studies...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29713454/is-adult-cardiac-regeneration-absent-in-xenopus-laevis-yet-present-in-xenopus-tropicalis
#5
Lindsey Marshall, Fabrice Girardot, Barbara A Demeneix, Laurent Coen
We recently used an endoscopy-based resection method to explore the consequences of cardiac injury in adult Xenopus laevis , obtaining the result that the adult Xenopus heart is unable to regenerate. At 11 months post-amputation, cellular and biological marks of scarring persisted. We thus concluded that, contrary to urodeles and teleosts, adult anurans share a cardiac injury outcome similar to adult mammals. However, in their work published in this journal on the 13 December 2017, Liao et al. showed that the adult Xenopus tropicalis heart is capable of efficient, almost scar free regeneration, a result at odds with our previous observation...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29713453/anti-ctla-4-antibodies-in-cancer-immunotherapy-selective-depletion-of-intratumoral-regulatory-t-cells-or-checkpoint-blockade
#6
Fei Tang, Xuexiang Du, Mingyue Liu, Pan Zheng, Yang Liu
Antibodies to human CTLA-4 have been shown to induce long-lasting protection against melanoma. It is assumed that these antibodies cause tumor rejection by blocking negative signaling from the B7-CTLA-4 interactions to enhance priming of naïve T cells in the lymphoid organs. Recently, we reported that anti-CTLA-4 antibody Ipilimumab effectively induces tumor rejection in vivo although it blocks neither B7 transendocytosis by CTLA-4 nor CTLA-4 binding to immobilized or cell-associated B7. Using genetic model in which the anti-CTLA-4 antibodies are unable to engage more than 50% of CTLA-4, we demonstrated that saturating binding of CTLA-4 is not necessary for tumor rejection...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29682276/characterization-and-potential-role-of-microrna-in-the-chinese-dominant-malaria-mosquito-anopheles-sinensis-diptera-culicidae-throughout-four-different-life-stages
#7
Xinyu Feng, Jiatong Wu, Shuisen Zhou, Jingwen Wang, Wei Hu
Background: microRNAs (miRNAs) are one kind of small non-coding RNAs widely distributed in insects. Many studies have shown that miRNAs play critical roles in development, differentiation, apoptosis, and innate immunity. However, there are a few reports describing miRNAs in Anopheles sinensis , the most common, and one of the dominant malaria mosquito in China. Here, we investigated the global miRNA expression profile across four different developmental stages including embryo, larval, pupal, and adult stages using Illumina Hiseq 2500 sequencing...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29651333/a-novel-organ-preservation-solution-with-efficient-clearance-of-red-blood-cells-improves-kidney-transplantation-in-a-canine-model
#8
Sheng Wang, Kristyn Gumpper, Tao Tan, Xianzhang Luo, Hui Guo, Changsheng Ming, Hanying Jiang, Jiangguo Fang, Guang Du, Hua Zhu, Jianjie Ma, Zhishui Chen, Nianqiao Gong
Organ preservation solutions are designed to minimize organ damage during transplantation. A novel preservation solution, WMO-II, was developed to have a low viscosity and to improve microvasculature perfusion for kidneys. In an autologous canine transplantation model, kidney function and recovery were evaluated after organs were flushed and cold-stored with WMO-II or HTK solution, a perfusate currently approved for clinical use. The average number of red blood cells remaining in a single glomerulus after flushing with WMO-II was significantly reduced when compared with HTK solution...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29636894/a-temporal-examination-of-calcium-signaling-in-cancer-from-tumorigenesis-to-immune-evasion-and-metastasis
#9
REVIEW
MengMeng Xu, Andreas Seas, Musa Kiyani, Keven S Y Ji, Hannah N Bell
Background: Although the study of calcium (Ca2+ ) is classically associated with excitable cells such as myocytes or neurons, the ubiquity of this essential element in all cellular processes has led to interest in other cell types. The importance of Ca2+ to apoptosis, cell signaling, and immune activation is of special import in cancer. Main: Here we review the current understanding of Ca2+ in each of these processes vital to the initiation, spread, and drug resistance of malignancies...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29632660/ghrelin-therapy-mitigates-bone-marrow-injury-and-splenocytopenia-by-sustaining-circulating-g-csf-and-kc-increases-after-irradiation-combined-with-wound
#10
Juliann G Kiang, Marsha N Anderson, Joan T Smith
Background: Radiation injury combined wound (CI) enhances acute radiation syndrome and subsequently mortality as compared to radiation injury alone (RI). We previously reported that ghrelin (a 28-amino-acid-peptide secreted from the stomach) treatment significantly increased a 30-day survival, mitigated hematopoietic death, circulating white blood cell (WBC) depletion and splenocytopenia and accelerated skin-wound healing on day 30 after CI. Herein, we aimed to study the ghrelin efficacy at early time points after CI...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29632659/inava-promotes-aggressiveness-of-papillary-thyroid-cancer-by-upregulating-mmp9-expression
#11
Hongyu Guan, Yan Guo, Liehua Liu, Runyi Ye, Weiwei Liang, Hai Li, Haipeng Xiao, Yanbing Li
Background: Innate immunity activator (INAVA) has been shown to be elevated in lung adenocarcinoma. However, its expression pattern and function in papillary thyroid cancer (PTC) are unknown. This study aimed to identify the clinical, biological, and mechanistic impacts of INAVA on PTC. Methods: Using The Cancer Genome Atlas dataset, real time PCR, and immunohistochemistry, the expression of INAVA in PTC was analyzed. Gain- and loss-of-function assays were performed to investigate the role of INAVA in PTC cell invasion, migration, and metastasis...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29599964/syncytium-calcium-signaling-and-macrophage-function-in-the-heart
#12
REVIEW
Xin Zhou, Zhongguang Li, Zefan Wang, Eda Chen, Juan Wang, Frederic Chen, Odell Jones, Tao Tan, Shawn Chen, Hiroshi Takeshima, Joseph Bryant, Jianjie Ma, Xuehong Xu
Macrophages are traditionally viewed as a key component of the immunity defense system. Recent studies have identified resident macrophages in multiple organs including the heart, in which the cells perform their crucial role on tissue repair after myocardial infarction (MI). The cardiac-specific macrophages interdigitate with cardiomyocytes particularly at the atrioventricular node region. The integrative communication between macrophage and cardiomyocytes can modulate the contractile function of the heart...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29588850/tp53tg1-enhances-cisplatin-sensitivity-of-non-small-cell-lung-cancer-cells-through-regulating-mir-18a-pten-axis
#13
Huijuan Xiao, Yihe Liu, Pan Liang, Bo Wang, Hongna Tan, Yonggao Zhang, Xianzheng Gao, Jianbo Gao
Background: The acquisition of drug resistance has been considered as a main obstacle for cancer chemotherapy. Tumor protein 53 target gene 1 (TP53TG1), a p53-induced lncRNA, plays a vital role in the progression of human cancers. However, little is known about the detailed function and molecular mechanism of TP53TG1 in cisplatin resistance of NSCLC. Methods: qRT-PCR analysis was used to detect the expression of TP53TG1, miR-18a and PTEN mRNA in NSCLC tissues and cells...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29588849/enhanced-calcium-ion-mobilization-in-osteoblasts-on-amino-group-containing-plasma-polymer-nanolayer
#14
Susanne Staehlke, Henrike Rebl, Birgit Finke, Petra Mueller, Martina Gruening, J Barbara Nebe
Background: Biomaterial modifications-chemical and topographical-are of particular importance for the integration of materials in biosystems. Cells are known to sense these biomaterial characteristics, but it has remained unclear which physiological processes bio modifications trigger. Hence, the question arises of whether the dynamic of intracellular calcium ions is important for the characterization of the cell-material interaction. In our prior research we could demonstrate that a defined geometrical surface topography affects the cell physiology; this was finally detectable in a reduced intracellular calcium mobilization after the addition of adenosine triphosphate (ATP)...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29568483/transplantation-of-endothelial-progenitor-cells-attenuated-paraquat-induced-acute-lung-injury-via-mir-141-3p-notch-nrf2-axis
#15
Yan Jin, Wei Liu, Xiaowei Liu, Tao Ma, Chen Yang, Quan Cai, Zhi Liu
Background: Paraquat (PQ) presents with high toxicity for humans and animals, and the lungs become the main target organ by the poisoning of PQ leading to acute lung injury. Endothelial progenitor cells (EPCs) were proved to have the repair function on acute lung injury (ALI). We aimed to invatigate the underlying mechanism of EPCs in PQ-induced ALI involving miR-141-3p. Methods: Endothelial progenitor cells were isolated from peripheral blood of C57BL/6J mice and identified by flow cytometry...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29541444/the-development-of-salt-sensitive-hypertension-regulated-by-psgl-1-gene-in-mice
#16
Yuhui Yang, Xue Liu, Yunpeng Liu, Hui Fu, Ying Gao, Xing Liu, Xiaoliang Jiang
Background and objective: Chronic inflammatory is involved in the development of salt-sensitive hypertension and other cardiovascular diseases. PSGL-1 plays an important role in the inflammatory response. Methods and results: In this study, we used PSGL-1-/- and PSGL-1+/+ mice fed with high salt diet to measure the blood pressure, inflammatory response and vascular injury. We found that, in PSGL-1+/+ mice, high salt diet resulted in high blood pressure with the increased expression of serum inflammatory cytokines IL-6, IL-1β and TNFɑ, vascular injury markers MCP-1, ET-1, and VWF, and renal macrophages and T cells infiltration, and endothelium-dependent acetylcholine vasodilation dysfunction...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29541443/lncrna-kcnq1ot1-promotes-osteogenic-differentiation-to-relieve-osteolysis-via-wnt-%C3%AE-catenin-activation
#17
Xuren Gao, Jian Ge, Weiyi Li, Wangchen Zhou, Lei Xu
Background: Resveratrol (RSV) has been reported to stimulate osteoblast differentiation in which Wnt/β-catenin signaling pathway played a crucial role. However, whether and how RSV activated Wnt/β-catenin pathway in osteogenic differentiation still remained elusive. Methods: In vivo polymethylmethacrylate (PMMA) particle-induced osteolysis (PIO) mouse model and in vitro PMMA particle-stimulated mouse mesenchymal stem cells (mMSCs) experiments were established...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29528047/correction-to-pml-regulation-and-multifaceted-function-beyond-tumor-suppression
#18
Kuo-Sheng Hsu, Hung-Ying Kao
[This corrects the article DOI: 10.1186/s13578-018-0204-8.].
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29507713/the-suppressing-role-of-mir-622-in-renal-cell-carcinoma-progression-by-down-regulation-of-ccl18-mapk-signal-pathway
#19
Tian Li, Xiangzhou Sun, Kewei Xu
Background: MicroRNAs have emerged as critical modulators of carcinogenesis and tumor progression including renal cell carcinoma (RCC). MiR-622 plays as a tumor inhibitor in some types of cancer, however, its role in kidney cancer is unknown. The purpose of the present work is to investigate the functional behaviors and regulatory mechanism of miR-622 in RCC. Results: We examined the expression of miR-622 in RCC and adjacent normal tissues and then explored the roles of miR-622...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29492259/long-non-coding-rna-casc2-improved-acute-lung-injury-by-regulating-mir-144-3p-aqp1-axis-to-reduce-lung-epithelial-cell-apoptosis
#20
Hongbin Li, Huijuan Shi, Min Gao, Ning Ma, Rongqing Sun
Background and objective: Apoptosis of lung epithelial cell is implicated in the pathogenesis of acute lung injury (ALI). To study the protective effect and mechanism of cancer susceptibility candidate 2 (CASC2) on reducing lung epithelial cell apoptosis after LPS inducing acute lung injury in mice. Methods and results: The ALI mice model was performed by intratracheally instilling with lipopolysaccharide (LPS). The CASC2 expression detected by quantitative real-time polymerase chain reaction was significantly decreased in LPS-induced A549 cell and ALI mice model...
2018: Cell & Bioscience
journal
journal
43593
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"