journal
https://read.qxmd.com/read/37127758/expression-of-myomaker-and-myomerger-in-myofibers-causes-muscle-pathology
#21
JOURNAL ARTICLE
Phillip C Witcher, Chengyi Sun, Douglas P Millay
BACKGROUND: Skeletal muscle development and regeneration depend on cellular fusion of myogenic progenitors to generate multinucleated myofibers. These progenitors utilize two muscle-specific fusogens, Myomaker and Myomerger, which function by remodeling cell membranes to fuse to each other or to existing myofibers. Myomaker and Myomerger expression is restricted to differentiating progenitor cells as they are not detected in adult myofibers. However, Myomaker remains expressed in myofibers from mice with muscular dystrophy...
May 1, 2023: Skeletal Muscle
https://read.qxmd.com/read/37087439/new-tools-for-the-investigation-of-muscle-fiber-type-spatial-distributions-across-histological-sections
#22
REVIEW
Anna K Redmond, Tilman M Davies, Matthew R Schofield, Philip W Sheard
BACKGROUND: The functional and metabolic properties of skeletal muscles are partly a function of the spatial arrangement of fibers across the muscle belly. Many muscles feature a non-uniform spatial pattern of fiber types, and alterations to the arrangement can reflect age or disease and correlate with changes in muscle mass and strength. Despite the significance of this event, descriptions of spatial fiber-type distributions across a muscle section are mainly provided qualitatively, by eye...
April 22, 2023: Skeletal Muscle
https://read.qxmd.com/read/36895061/extracellular-vesicle-distribution-and-localization-in-skeletal-muscle-at-rest-and-following-disuse-atrophy
#23
JOURNAL ARTICLE
Ahmed Ismaeel, Douglas W Van Pelt, Zachary R Hettinger, Xu Fu, Christopher I Richards, Timothy A Butterfield, Jonathan J Petrocelli, Ivan J Vechetti, Amy L Confides, Micah J Drummond, Esther E Dupont-Versteegden
BACKGROUND: Skeletal muscle (SkM) is a large, secretory organ that produces and releases myokines that can have autocrine, paracrine, and endocrine effects. Whether extracellular vesicles (EVs) also play a role in the SkM adaptive response and ability to communicate with other tissues is not well understood. The purpose of this study was to investigate EV biogenesis factors, marker expression, and localization across cell types in the skeletal muscle. We also aimed to investigate whether EV concentrations are altered by disuse atrophy...
March 10, 2023: Skeletal Muscle
https://read.qxmd.com/read/36882853/the-double-homeodomain-protein-dux4c-is-associated-with-regenerating-muscle-fibers-and-rna-binding-proteins
#24
JOURNAL ARTICLE
Clothilde Claus, Moriya Slavin, Eugénie Ansseau, Céline Lancelot, Karimatou Bah, Saskia Lassche, Manon Fiévet, Anna Greco, Sara Tomaiuolo, Alexandra Tassin, Virginie Dudome, Benno Kusters, Anne-Emilie Declèves, Dalila Laoudj-Chenivesse, Baziel G M van Engelen, Denis Nonclercq, Alexandra Belayew, Nir Kalisman, Frédérique Coppée
BACKGROUND: We have previously demonstrated that double homeobox 4 centromeric (DUX4C) encoded for a functional DUX4c protein upregulated in dystrophic skeletal muscles. Based on gain- and loss-of-function studies we have proposed DUX4c involvement in muscle regeneration. Here, we provide further evidence for such a role in skeletal muscles from patients affected with facioscapulohumeral muscular dystrophy (FSHD). METHODS: DUX4c was studied at RNA and protein levels in FSHD muscle cell cultures and biopsies...
March 7, 2023: Skeletal Muscle
https://read.qxmd.com/read/36859305/an-updated-c-elegans-nuclear-body-muscle-transcriptome-for-studies-in-muscle-formation-and-function
#25
JOURNAL ARTICLE
Anna L Schorr, Alejandro Felix Mejia, Martina Y Miranda, Marco Mangone
The body muscle is an important tissue used in organisms for proper viability and locomotion. Although this tissue is generally well studied and characterized, and many pathways have been elucidated throughout the years, we still lack a comprehensive understanding of its transcriptome and how it controls muscle development and function. Here, we have updated a nuclear FACS sorting-based methodology to isolate and sequence a high-quality muscle transcriptome from Caenorhabditis elegans mixed-stage animals. We have identified 2848 muscle-specific protein-coding genes, including 78 transcription factors and 206 protein-coding genes containing an RNA binding domain...
March 2, 2023: Skeletal Muscle
https://read.qxmd.com/read/36788624/angiogenesis-precedes-myogenesis-during-regeneration-following-biopsy-injury-of-skeletal-muscle
#26
JOURNAL ARTICLE
Nicole L Jacobsen, Aaron B Morton, Steven S Segal
BACKGROUND: Acute injury to skeletal muscle damages myofibers and fragment capillaries, impairing contractile function and local perfusion. Myofibers and microvessels regenerate from satellite cells and from surviving microvessel fragments, respectively, to restore intact muscle. Established models of injury have used myotoxins and physical trauma to demonstrate the concurrence of myogenesis and angiogenesis during regeneration. In these models, efferocytosis removes cellular debris while basal laminae persist to provide guidance during myofiber and microvessel regeneration...
February 14, 2023: Skeletal Muscle
https://read.qxmd.com/read/36658632/sarcopenia-investigation-of-metabolic-changes-and-its-associated-mechanisms
#27
JOURNAL ARTICLE
Jair Marques, Engy Shokry, Olaf Uhl, Lisa Baber, Fabian Hofmeister, Stefanie Jarmusch, Martin Bidlingmaier, Uta Ferrari, Berthold Koletzko, Michael Drey
BACKGROUND: Sarcopenia is one of the most predominant musculoskeletal diseases of the elderly, defined as age-related progressive and generalized loss of muscle mass with a simultaneous reduction in muscle strength and/or function. Using metabolomics, we aimed to examine the association between sarcopenia and the plasma metabolic profile of sarcopenic patients, measured using a targeted HPLC-MS/MS platform. METHODS: Plasma samples from 22 (17 men) hip fracture patients undergoing surgery (8 sarcopenic, age 81...
January 19, 2023: Skeletal Muscle
https://read.qxmd.com/read/36609344/multi-omics-analysis-of-sarcospan-overexpression-in-mdx-skeletal-muscle-reveals-compensatory-remodeling-of-cytoskeleton-matrix-interactions-that-promote-mechanotransduction-pathways
#28
JOURNAL ARTICLE
Jackie L McCourt, Kristen M Stearns-Reider, Hafsa Mamsa, Pranav Kannan, Mohammad Hossein Afsharinia, Cynthia Shu, Elizabeth M Gibbs, Kara M Shin, Yerbol Z Kurmangaliyev, Lauren R Schmitt, Kirk C Hansen, Rachelle H Crosbie
BACKGROUND: The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of the muscle cell membrane, providing a mechanical link between the extracellular matrix (ECM) and the cortical cytoskeleton that stabilizes the sarcolemma during repeated muscle contractions. One integral component of the DGC is the transmembrane protein, sarcospan (SSPN). Overexpression of SSPN in the skeletal muscle of mdx mice (murine model of DMD) restores muscle fiber attachment to the ECM in part through an associated increase in utrophin and integrin adhesion complexes at the cell membrane, protecting the muscle from contraction-induced injury...
January 6, 2023: Skeletal Muscle
https://read.qxmd.com/read/36539856/the-prevalence-of-low-muscle-mass-associated-with-obesity-in-the-usa
#29
JOURNAL ARTICLE
Dana J Murdock, Ning Wu, Joseph S Grimsby, Roberto A Calle, Stephen Donahue, David J Glass, Mark W Sleeman, Robert J Sanchez
BACKGROUND: Sarcopenia is defined as age-related low muscle mass and function, and can also describe the loss of muscle mass in certain medical conditions, such as sarcopenic obesity. Sarcopenic obesity describes loss of muscle and function in obese individuals; however, as sarcopenia is an age-related condition and obesity can occur in any age group, a more accurate term is obesity with low lean muscle mass (OLLMM). Given limited data on OLLMM (particularly in those aged < 65 years), the purpose of this study was to estimate the prevalence of OLLMM in adults aged ≥ 20 years in the USA...
December 21, 2022: Skeletal Muscle
https://read.qxmd.com/read/36447272/limb-girdle-muscular-dystrophy-type-2b-causes-hdl-c-abnormalities-in-patients-and-statin-resistant-muscle-wasting-in-dysferlin-deficient-mice
#30
JOURNAL ARTICLE
Zoe White, Zeren Sun, Elodie Sauge, Dan Cox, Graham Donen, Dmitri Pechkovsky, Volker Straub, Gordon A Francis, Pascal Bernatchez
Limb-girdle muscular dystrophy (MD) type 2B (LGMD2B) and Duchenne MD (DMD) are caused by mutations to the Dysferlin and Dystrophin genes, respectively. We have recently demonstrated in typically mild dysferlin- and dystrophin-deficient mouse models that increased plasma cholesterol levels severely exacerbate muscle wasting, and that DMD patients display primary dyslipidemia characterized by elevated plasma cholesterol and triglycerides. Herein, we investigate lipoprotein abnormalities in LGMD2B and if statin therapy protects dysferlin-deficient mice (Dysf) from muscle damage...
November 29, 2022: Skeletal Muscle
https://read.qxmd.com/read/36258243/macroglossia-and-less-advanced-dystrophic-change-in-the-tongue-muscle-of-the-duchenne-muscular-dystrophy-rat
#31
JOURNAL ARTICLE
Keitaro Yamanouchi, Yukie Tanaka, Masanari Ikeda, Shizuka Kato, Ryosuke Okino, Hiroki Nishi, Fumihiko Hakuno, Shin-Ichiro Takahashi, James Chambers, Takashi Matsuwaki, Kazuyuki Uchida
BACKGROUND: Duchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by a complete lack of dystrophin, which stabilizes the plasma membrane of myofibers. The orofacial function is affected in an advanced stage of DMD and this often leads to an eating disorder such as dysphagia. Dysphagia is caused by multiple etiologies including decreased mastication and swallowing. Therefore, preventing the functional declines of mastication and swallowing in DMD is important to improve the patient's quality of life...
October 19, 2022: Skeletal Muscle
https://read.qxmd.com/read/36175989/megaconial-congenital-muscular-dystrophy-due-to-novel-chkb-variants-a-case-report-and-literature-review
#32
REVIEW
Francesca Magri, Sara Antognozzi, Michela Ripolone, Simona Zanotti, Laura Napoli, Patrizia Ciscato, Daniele Velardo, Giulietta Scuvera, Valeria Nicotra, Antonella Giacobbe, Donatella Milani, Francesco Fortunato, Manuela Garbellini, Monica Sciacco, Stefania Corti, Giacomo Pietro Comi, Dario Ronchi
BACKGROUND: Choline kinase beta (CHKB) catalyzes the first step in the de novo biosynthesis of phosphatidyl choline and phosphatidylethanolamine via the Kennedy pathway. Derangement of this pathway might also influence the homeostasis of mitochondrial membranes. Autosomal recessive CHKB mutations cause a rare form of congenital muscular dystrophy known as megaconial congenital muscular dystrophy (MCMD). CASE PRESENTATION: We describe a novel proband presenting MCMD due to unpublished CHKB mutations...
September 29, 2022: Skeletal Muscle
https://read.qxmd.com/read/36089582/mouse-models-of-sma-show-divergent-patterns-of-neuronal-vulnerability-and-resilience
#33
JOURNAL ARTICLE
Victoria Woschitz, Irene Mei, Eva Hedlund, Lyndsay M Murray
BACKGROUND: Spinal muscular atrophy (SMA) is a form of motor neuron disease affecting primarily children characterised by the loss of lower motor neurons (MNs). Breakdown of the neuromuscular junctions (NMJs) is an early pathological event in SMA. However, not all motor neurons are equally vulnerable, with some populations being lost early in the disease while others remain intact at the disease end-stage. A thorough understanding of the basis of this selective vulnerability will give critical insight into the factors which prohibit pathology in certain motor neuron populations and consequently help identify novel neuroprotective strategies...
September 12, 2022: Skeletal Muscle
https://read.qxmd.com/read/36085166/identification-of-the-co-differentially-expressed-hub-genes-involved-in-the-endogenous-protective-mechanism-against-ventilator-induced-diaphragm-dysfunction
#34
JOURNAL ARTICLE
Dong Zhang, Wenyan Hao, Qi Niu, Dongdong Xu, Xuejiao Duan
BACKGROUND: In intensive care units (ICU), mechanical ventilation (MV) is commonly applied to save patients' lives. However, ventilator-induced diaphragm dysfunction (VIDD) can complicate treatment by hindering weaning in critically ill patients and worsening outcomes. The goal of this study was to identify potential genes involved in the endogenous protective mechanism against VIDD. METHODS: Twelve adult male rabbits were assigned to either an MV group or a control group under the same anesthetic conditions...
September 9, 2022: Skeletal Muscle
https://read.qxmd.com/read/35971133/prolonged-fos-activity-disrupts-a-global-myogenic-transcriptional-program-by-altering-3d-chromatin-architecture-in-primary-muscle-progenitor-cells
#35
JOURNAL ARTICLE
A Rasim Barutcu, Gabriel Elizalde, Alfredo E Gonzalez, Kartik Soni, John L Rinn, Amy J Wagers, Albert E Almada
BACKGROUND: The AP-1 transcription factor, FBJ osteosarcoma oncogene (FOS), is induced in adult muscle satellite cells (SCs) within hours following muscle damage and is required for effective stem cell activation and muscle repair. However, why FOS is rapidly downregulated before SCs enter cell cycle as progenitor cells (i.e., transiently expressed) remains unclear. Further, whether boosting FOS levels in the proliferating progeny of SCs can enhance their myogenic properties needs further evaluation...
August 15, 2022: Skeletal Muscle
https://read.qxmd.com/read/35906707/oxidative-stress-induced-premature-senescence-and-aggravated-denervated-skeletal-muscular-atrophy-by-regulating-progerin-p53-interaction
#36
JOURNAL ARTICLE
Yaoxian Xiang, Zongqi You, Xinying Huang, Junxi Dai, Junpeng Zhang, Shuqi Nie, Lei Xu, Junjian Jiang, Jianguang Xu
BACKGROUND: Progerin elevates atrophic gene expression and helps modify the nuclear membrane to cause severe muscle pathology, which is similar to muscle weakness in the elderly, to alter the development and function of the skeletal muscles. Stress-induced premature senescence (SIPS), a state of cell growth arrest owing to such stimuli as oxidation, can be caused by progerin. However, evidence for whether SIPS-induced progerin accumulation is connected to denervation-induced muscle atrophy is not sufficient...
July 29, 2022: Skeletal Muscle
https://read.qxmd.com/read/35902978/dysregulation-of-tweak-and-fn14-in-skeletal-muscle-of-spinal-muscular-atrophy-mice
#37
JOURNAL ARTICLE
Katharina E Meijboom, Emma R Sutton, Eve McCallion, Emily McFall, Daniel Anthony, Benjamin Edwards, Sabrina Kubinski, Ines Tapken, Ines Bünermann, Gareth Hazell, Nina Ahlskog, Peter Claus, Kay E Davies, Rashmi Kothary, Matthew J A Wood, Melissa Bowerman
BACKGROUND: Spinal muscular atrophy (SMA) is a childhood neuromuscular disorder caused by depletion of the survival motor neuron (SMN) protein. SMA is characterized by the selective death of spinal cord motor neurons, leading to progressive muscle wasting. Loss of skeletal muscle in SMA is a combination of denervation-induced muscle atrophy and intrinsic muscle pathologies. Elucidation of the pathways involved is essential to identify the key molecules that contribute to and sustain muscle pathology...
July 28, 2022: Skeletal Muscle
https://read.qxmd.com/read/35794679/differences-in-muscle-satellite-cell-dynamics-during-muscle-hypertrophy-and-regeneration
#38
REVIEW
So-Ichiro Fukada, Tatsuyoshi Higashimoto, Akihiro Kaneshige
Skeletal muscle homeostasis and function are ensured by orchestrated cellular interactions among several types of cells. A noticeable aspect of skeletal muscle biology is the drastic cell-cell communication changes that occur in multiple scenarios. The process of recovering from an injury, which is known as regeneration, has been relatively well investigated. However, the cellular interplay that occurs in response to mechanical loading, such as during resistance training, is poorly understood compared to regeneration...
July 6, 2022: Skeletal Muscle
https://read.qxmd.com/read/35780170/high-throughput-muscle-fiber-typing-from-rna-sequencing-data
#39
JOURNAL ARTICLE
Nikolay Oskolkov, Malgorzata Santel, Hemang M Parikh, Ola Ekström, Gray J Camp, Eri Miyamoto-Mikami, Kristoffer Ström, Bilal Ahmad Mir, Dmytro Kryvokhyzha, Mikko Lehtovirta, Hiroyuki Kobayashi, Ryo Kakigi, Hisashi Naito, Karl-Fredrik Eriksson, Björn Nystedt, Noriyuki Fuku, Barbara Treutlein, Svante Pääbo, Ola Hansson
BACKGROUND: Skeletal muscle fiber type distribution has implications for human health, muscle function, and performance. This knowledge has been gathered using labor-intensive and costly methodology that limited these studies. Here, we present a method based on muscle tissue RNA sequencing data (totRNAseq) to estimate the distribution of skeletal muscle fiber types from frozen human samples, allowing for a larger number of individuals to be tested. METHODS: By using single-nuclei RNA sequencing (snRNAseq) data as a reference, cluster expression signatures were produced by averaging gene expression of cluster gene markers and then applying these to totRNAseq data and inferring muscle fiber nuclei type via linear matrix decomposition...
July 2, 2022: Skeletal Muscle
https://read.qxmd.com/read/35751105/correction-estrogen-signaling-effects-on-muscle-specific-immune-responses-through-controlling-the-recruitment-and-function-of-macrophages-and-t-cells
#40
Zhao Hong Liao, Tao Huang, Jiang Wei Xiao, Rui Cai Gu, Jun Ouyang, Gang Wu, Hua Liao
No abstract text is available yet for this article.
June 24, 2022: Skeletal Muscle
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