journal
MENU ▼
Read by QxMD icon Read
search

Frontiers in Immunology

journal
https://www.readbyqxmd.com/read/30643501/cd47-expression-in-natural-killer-cells-regulates-homeostasis-and-modulates-immune-response-to-lymphocytic-choriomeningitis-virus
#1
Pulak Ranjan Nath, Arunakumar Gangaplara, Dipasmita Pal-Nath, Ajeet Mandal, Dragan Maric, John M Sipes, Maggie Cam, Ethan M Shevach, David D Roberts
CD47 is a ubiquitous cell surface receptor that directly regulates T cell immunity by interacting with its inhibitory ligand thrombospondin-1 and limits clearance of cells by phagocytes that express its counter-receptor signal-regulatory protein-α. Murine natural killer (NK) cells express higher levels of CD47 than other lymphocytes, but the role of CD47 in regulating NK cell homeostasis and immune function remains unclear. Cd47 -/- mice exhibited depletion of NK precursors in bone marrow, consistent with the antiphagocytic function of CD47...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30631328/the-pattern-of-malignancies-in-down-syndrome-and-its-potential-context-with-the-immune-system
#2
REVIEW
Daniel Satgé, Markus G Seidel
The immune surveillance theory of cancer posits that the body's immune system detects and destroys randomly occurring malignant cells. This theory is based on the observation of the increased frequency of malignancies in primary and secondary immunodeficiencies, and is supported by the successful demonstration of immune augmentation in current oncological immune therapy approaches. We review this model in the context of Down syndrome (DS), a condition with a unique tumor profile and various immune defects. Children and adults with DS are more prone to infections due to anatomical reasons and a varying degree of T- and B-cell maturation defects, NK cell dysfunction, and chemotactic or phagocytic abnormalities...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30631327/inflammasomes-emerging-central-players-in-cancer-immunology-and-immunotherapy
#3
REVIEW
Dev Karan
Inflammation has an established role in cancer development and progression and is a key player in regulating the entry and exit of immune cells in the tumor microenvironment, mounting a significant impact on anti-tumor immunity. Recent studies have shed light on the role of inflammasomes in the regulation of inflammation with a focus on the subsequent effects on the immunobiology of tumors. To generate strong anti-tumor immunity, cross-talk between innate, and adaptive immune cells is necessary. Interestingly, inflammasome bridges both arms of the immune system representing a unique opportunity to manipulate the role of inflammation in favor of tumor suppression...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30631326/development-and-validation-of-a-multiplex-non-hla-antibody-assay-for-the-screening-of-kidney-transplant-recipients
#4
Elena G Kamburova, Tineke Kardol-Hoefnagel, Bram W Wisse, Irma Joosten, Wil A Allebes, Arnold van der Meer, Luuk B Hilbrands, Marije C Baas, Eric Spierings, Cornelis E Hack, Franka E van Reekum, Arjan D van Zuilen, Marianne C Verhaar, Michiel L Bots, Adriaan C A D Drop, Loes Plaisier, Jan Meeldijk, Niels Bovenschen, Marc A J Seelen, Jan Stephan Sanders, Bouke G Hepkema, Annechien J A Lambeck, Laura B Bungener, Caroline Roozendaal, Marcel G J Tilanus, Christina E Voorter, Lotte Wieten, Elly M van Duijnhoven, Mariëlle A C J Gelens, Maarten H L Christiaans, Frans J van Ittersum, Shaikh A Nurmohamed, Neubury M Lardy, Wendy Swelsen, Karlijn A M I van der Pant, Neelke C van der Weerd, Ineke J M Ten Berge, Frederike J Bemelman, Paul J M van der Boog, Johan W de Fijter, Michiel G H Betjes, Sebastiaan Heidt, Dave L Roelen, Frans H Claas, Henny G Otten
The best treatment for patients with end-stage renal disease is kidney transplantation. Although graft survival rates have improved in the last decades, patients still may lose their grafts partly due to the detrimental effects of donor-specific antibodies (DSA) against human leukocyte antigens (HLA) and to a lesser extent also by antibodies directed against non-HLA antigens expressed on the donor endothelium. Assays to detect anti-HLA antibodies are already in use for many years and have been proven useful for transplant risk stratification...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30631325/cytotoxic-pathways-in-allogeneic-hematopoietic-cell-transplantation
#5
REVIEW
Wei Du, Xuefang Cao
Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment for hematologic malignancies, and other hematologic and immunologic diseases. Donor-derived immune cells identify and attack cancer cells in the patient producing a unique graft-vs.-tumor (GVT) effect. This beneficial response renders allo-HCT one of the most effective forms of tumor immunotherapy. However, alloreactive donor T cells can damage normal host cells thereby causing graft-vs.-host disease (GVHD), which results in substantial morbidity and mortality...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30631324/design-of-peptide-based-nanovaccines-targeting-leading-antigens-from-gynecological-cancers-to-induce-hla-a2-1-restricted-cd8-t-cell-responses
#6
Sue D Xiang, Kirsty L Wilson, Anne Goubier, Arne Heyerick, Magdalena Plebanski
Gynecological cancers are a leading cause of mortality in women. CD8+ T cell immunity largely correlates with enhanced survival, whereas inflammation is associated with poor prognosis. Previous studies have shown polystyrene nanoparticles (PSNPs) are biocompatible, do not induce inflammation and when used as vaccine carriers for model peptides induce CD8+ T cell responses. Herein we test the immunogenicity of 24 different peptides, from three leading vaccine target proteins in gynecological cancers: the E7 protein of human papilloma virus (HPV); Wilms Tumor antigen 1 (WT1) and survivin (SV), in PSNP conjugate vaccines...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30631323/the-contribution-of-co-signaling-pathways-to-anti-malarial-t-cell-immunity
#7
REVIEW
Rebecca Faleiro, Deshapriya S Karunarathne, Joshua M Horne-Debets, Michelle Wykes
Plasmodium spp., the causative agent of malaria, caused 212 million infections in 2016 with 445,000 deaths, mostly in children. Adults acquire enough immunity to prevent clinical symptoms but never develop sterile immunity. The only vaccine for malaria, RTS,S, shows promising protection of a limited duration against clinical malaria in infants but no significant protection against severe disease. There is now abundant evidence that T cell functions are inhibited during malaria, which may explain why vaccine are not efficacious...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30631322/-mycobacterium-leprae-recombinant-antigen-induces-high-expression-of-multifunction-t-lymphocytes-and-is-promising-as-a-specific-vaccine-for-leprosy
#8
Márcio Bezerra-Santos, Marise do Vale-Simon, Aline Silva Barreto, Rodrigo Anselmo Cazzaniga, Daniela Teles de Oliveira, Mônica Rueda Barrios, Alex Ricardo Ferreira, Nanci C Santos-Bio, Steven G Reed, Roque Pacheco de Almeida, Cristiane Bani Corrêa, Malcolm S Duthie, Amélia Ribeiro de Jesus
Leprosy is a chronic disease caused by M. leprae infection that can cause severe neurological complications and physical disabilities. A leprosy-specific vaccine would be an important component within control programs but is still lacking. Given that multifunctional CD4 T cells [i.e., those capable of simultaneously secreting combinations of interferon (IFN)-γ, interleukin (IL)-2, and tumor necrosis factor (TNF)] have now been implicated in the protective response to several infections, we tested the hypothesis if a recombinant M...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30631321/more-than-just-a-removal-service-scavenger-receptors-in-leukocyte-trafficking
#9
REVIEW
Daniel A Patten, Shishir Shetty
Scavenger receptors are a highly diverse superfamily of proteins which are grouped by their inherent ability to bind and internalize a wide array of structurally diverse ligands which can be either endogenous or exogenous in nature. Consequently, scavenger receptors are known to play important roles in host homeostasis, with common endogenous ligands including apoptotic cells, and modified low density lipoproteins (LDLs); additionally, scavenger receptors are key regulators of inflammatory diseases, such as atherosclerosis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30631320/leveraging-multilayered-omics-data-for-atopic-dermatitis-a-road-map-to-precision-medicine
#10
REVIEW
Debajyoti Ghosh, Jonathan A Bernstein, Gurjit K Khurana Hershey, Marc E Rothenberg, Tesfaye B Mersha
Atopic dermatitis (AD) is a complex multifactorial inflammatory skin disease that affects ~280 million people worldwide. About 85% of AD cases begin in childhood, a significant portion of which can persist into adulthood. Moreover, a typical progression of children with AD to food allergy, asthma or allergic rhinitis has been reported ("allergic march" or "atopic march"). AD comprises highly heterogeneous sub-phenotypes/endotypes resulting from complex interplay between intrinsic and extrinsic factors, such as environmental stimuli, and genetic factors regulating cutaneous functions (impaired barrier function, epidermal lipid, and protease abnormalities), immune functions and the microbiome...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30631319/humanized-mice-are-instrumental-to-the-study-of-plasmodium-falciparum-infection
#11
REVIEW
Rajeev K Tyagi, Nikunj Tandel, Richa Deshpande, Robert W Engelman, Satish D Patel, Priyanka Tyagi
Research using humanized mice has advanced our knowledge and understanding of human haematopoiesis, non-adaptive and adaptive immunity, autoimmunity, infectious disease, cancer biology, and regenerative medicine. Challenges posed by the human-malaria parasite Plasmodium falciparum include its complex life cycle, the evolution of drug resistance against anti-malarials, poor diagnosis, and a lack of effective vaccines. Advancements in genetically engineered and immunodeficient mouse strains, have allowed for studies of the asexual blood stage, exoerythrocytic stage and the transition from liver-to-blood stage infection, in a single vertebrate host...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30627131/vascular-targeting-to-increase-the-efficiency-of-immune-checkpoint-blockade-in-cancer
#12
REVIEW
Maria Georganaki, Luuk van Hooren, Anna Dimberg
Boosting natural immunity against malignant cells has had a major breakthrough in clinical cancer therapy. This is mainly due to the successful development of immune checkpoint blocking antibodies, which release a break on cytolytic anti-tumor-directed T-lymphocytes. However, immune checkpoint blockade is only effective for a proportion of cancer patients, and a major challenge in the field is to understand and overcome treatment resistance. Immune checkpoint blockade relies on successful trafficking of tumor-targeted T-lymphocytes from the secondary lymphoid organs, through the blood stream and into the tumor tissue...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30627130/macrophage-neisseria-gonorrhoeae-interactions-a-better-understanding-of-pathogen-mechanisms-of-immunomodulation
#13
REVIEW
Alejandro Escobar, Paula I Rodas, Claudio Acuña-Castillo
Neisseria gonorrhoeae is a significant health problem worldwide due to multi-drug resistance issues and absence of an effective vaccine. Patients infected with N. gonorrhoeae have not shown a better immune response in successive infections. This might be explained by the fact that N. gonorrhoeae possesses several mechanisms to evade the innate and adaptative immune responses at different levels. Macrophages are a key cellular component in the innate immune response against microorganisms. The current information suggests that gonococcus can hijack the host response by mechanisms that involve the control of macrophages activity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30627129/the-role-of-co-stimulatory-co-inhibitory-signals-in-graft-vs-host-disease
#14
REVIEW
Sandeep Kumar, Nicholas D Leigh, Xuefang Cao
Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective immunotherapeutic approach for various hematologic and immunologic ailments. Despite the beneficial impact of allo-HCT, its adverse effects cause severe health concerns. After transplantation, recognition of host cells as foreign entities by donor T cells induces graft-vs.-host disease (GVHD). Activation, proliferation and trafficking of donor T cells to target organs and tissues are critical steps in the pathogenesis of GVHD. T cell activation is a synergistic process of T cell receptor (TCR) recognition of major histocompatibility complex (MHC)-anchored antigen and co-stimulatory/co-inhibitory signaling in the presence of cytokines...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30627128/oral-administration-of-human-polyvalent-igg-by-mouthwash-as-an-adjunctive-treatment-of-chronic-oral-candidiasis
#15
Sigifredo Pedraza-Sánchez, Julia I Méndez-León, Yolanda Gonzalez, María Laura Ventura-Ayala, María Teresa Herrera, Jose Luis Lezana-Fernández, Joseph A Bellanti, Martha Torres
Candida albicans is a commensal fungus that can cause disease ranging in severity from moderate to severe mucosal infections to more serious life-threating disseminated infections in severely immunocompromised hosts. Chronic mucocutaneous candidiasis (CMC) occurs in patients with mutations in genes affecting IL-17-mediated immunity, such as STAT3, AIRE, RORC, CARD9, IL12B , and IL12RB1 , or gain of function (GOF) mutations in STAT1 . New strategies for the treatment of candidiasis are needed because of the increased burden of infections and the emergence of drug-resistant strains...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30622543/a-possible-reason-to-induce-acute-graft-vs-host-disease-after-hematopoietic-stem-cell-transplantation-lack-of-sirtuin-1-in-cd4-t-cells
#16
Ya-Jing Xu, Fang-Ping Chen, Yan Chen, Bin Fu, En-Yi Liu, Lang Zou, Lin-Xin Liu
Sirtuin 1 (SIRT1) is a critical suppressor of T cell immunity. However, whether SIRT1 is involved in the progression of acute graft-vs.-host disease (aGVHD) has still remained unclear. PI3K/Akt/mTOR pathway is a crucial element involved in the activation and functions of T cells. Over-activation of PI3K/Akt/mTOR signaling may be related to the occurrence of aGVHD. STAT3 activation requires phosphorylation and acetylation. A recent study showed that STAT3 hyperphosphorylation in CD4+ T cells may be a trigger of aGVHD...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30622542/human-plasmacytoid-and-monocyte-derived-dendritic-cells-display-distinct-metabolic-profile-upon-rig-i-activation
#17
Tünde Fekete, Mate I Sütö, Dora Bencze, Anett Mázló, Attila Szabo, Tamas Biro, Attila Bacsi, Kitti Pazmandi
Recent advances reveal that metabolic reprogramming is required for adequate antiviral responses of dendritic cells (DCs) that possess the capacity to initiate innate and adaptive immune responses. Several reports indicate that Toll-like receptor (TLR) stimulation of DCs is accompanied by a rapid induction of glycolysis; however, the metabolic requirements of retinoic-acid inducible gene I (RIG-I)-like receptor (RLR) activation have not defined either in conventional DCs (cDCs) or in plasmacytoid DCs (pDCs) that are the major producers of type I interferons (IFN) upon viral infections...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30622541/regulation-of-gvhd-and-gvl-activity-via-pd-l1-interaction-with-pd-1-and-cd80
#18
REVIEW
Kaniel Cassady, Paul J Martin, Defu Zeng
Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for hematological malignancies (i.e. leukemia and lymphoma), because graft-versus-leukemia (GVL) activity mediated by alloreactive T cells can eliminate residual malignant cells and prevent relapse. However, the same alloreactive T cells also mediate a severe side effect, graft-versus-host disease (GVHD), and prevention of GVHD while preserving GVL activity remains an elusive goal. The immune checkpoint molecule PD-L1 and its interaction with PD-1 receptor in regulating cancer immunity is under intensive and wide-spread study, but knowledge about this interaction in regulating GVHD and GVL activity is very limited...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30622540/inos-activity-is-required-for-the-therapeutic-effect-of-mesenchymal-stem-cells-in-experimental-systemic-sclerosis
#19
Alexandre T J Maria, Pauline Rozier, Guillaume Fonteneau, Thibault Sutra, Marie Maumus, Karine Toupet, Jean-Paul Cristol, Christian Jorgensen, Philippe Guilpain, Danièle Noël
Objectives: Fibrosis is a hallmark of systemic sclerosis (SSc), an intractable disease where innovative strategies are still being sought. Among novel anti-fibrotic approaches, mesenchymal stromal/stem cell (MSC)-based therapy appears promising. Previously, we reported anti-fibrotic effects of MSC in an experimental model of SSc, through various mechanisms (tissue remodeling, immunomodulation, anti-oxidant defense). Since immunomodulation is a pivotal mechanism for MSC therapeutic effects, we investigated the specific role of critical molecules associated with MSC immunosuppressive properties and hypothesized that MSC defective for these molecules would be less effective in reducing fibrosis in SSc...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30622539/mesenchymal-stromal-cell-derived-exosomes-affect-mrna-expression-and-function-of-b-lymphocytes
#20
Drirh Khare, Reuven Or, Igor Resnick, Claudine Barkatz, Osnat Almogi-Hazan, Batia Avni
Background: Bone marrow mesenchymal stem cells (bmMSC) may play a role in the regulation of maturation, proliferation, and functional activation of lymphocytes, though the exact mechanisms are unknown. MSC-derived exosomes induce a regulatory response in the function of B, T, and monocyte-derived dendritic cells. Here, we evaluated the specific inhibition of human lymphocytes by bmMSC-derived exosomes and the effects on B-cell function. Methods: Exosomes were isolated from culture media of bmMSC obtained from several healthy donors...
2018: Frontiers in Immunology
journal
journal
43587
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"