journal
https://read.qxmd.com/read/38536511/repeatability-of-18-f-fdg-uptake-in-metastatic-bone-lesions-of-breast-cancer-patients-and-implications-for-accrual-to-clinical-trials
#1
JOURNAL ARTICLE
Mark Muzi, Lanell M Peterson, Jennifer M Specht, Daniel S Hippe, Alena Novakova-Jiresova, Jean H Lee, Brenda F Kurland, David A Mankoff, Nancy Obuchowski, Hannah M Linden, Paul E Kinahan
BACKGROUND: Standard measures of response such as Response Evaluation Criteria in Solid Tumors are ineffective for bone lesions, often making breast cancer patients that have bone-dominant metastases ineligible for clinical trials with potentially helpful therapies. In this study we prospectively evaluated the test-retest uptake variability of 2-deoxy-2-[18F]fluoro-D-glucose (18 F-FDG) in a cohort of breast cancer patients with bone-dominant metastases to determine response criteria. The thresholds for 95% specificity of change versus no-change were then applied to a second cohort of breast cancer patients with bone-dominant metastases...
March 27, 2024: EJNMMI Research
https://read.qxmd.com/read/38528239/increased-lesion-detectability-in-patients-with-locally-advanced-breast-cancer-a-pilot-study-using-dynamic-whole-body-18-f-fdg-pet-ct
#2
JOURNAL ARTICLE
Mette Abildgaard Pedersen, André H Dias, Karin Hjorthaug, Lars C Gormsen, Joan Fledelius, Anna Lyhne Johnsson, Signe Borgquist, Trine Tramm, Ole Lajord Munk, Mikkel Holm Vendelbo
BACKGROUND: Accurate diagnosis of axillary lymph node (ALN) metastases is essential for prognosis and treatment planning in breast cancer. Evaluation of ALN is done by ultrasound, which is limited by inter-operator variability, and by sentinel lymph node biopsy and/or ALN dissection, none of which are without risks and/or long-term complications. It is known that conventional 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) positron emission tomography/computed tomography (PET/CT) has limited sensitivity for ALN metastases...
March 25, 2024: EJNMMI Research
https://read.qxmd.com/read/38517637/biodistribution-and-dosimetry-of-177-lu-dota-iba-for-therapy-of-bone-metastases
#3
JOURNAL ARTICLE
Hongmei Li, Wenjie Pei, Xiqun Yang, Gengcuo Qu, Qingchu Hua, Lin Liu, Yudi Wang, Tingting Xu, Yue Chen
BACKGROUND: We designed and synthesized a novel bisphosphonate radiopharmaceutical (68  Ga- or 177 Lu-labeled DOTA-ibandronate [68  Ga/177 Lu-DOTA-IBA]) for the targeted diagnosis and treatment of bone metastases. The biodistribution and internal dosimetry of a single therapeutic dose of 177 Lu-DOTA-IBA were evaluated using a series of single-photon emission computerized tomography (SPECT) images and blood samples. Five patients with multiple bone metastases were included in this prospective study...
March 22, 2024: EJNMMI Research
https://read.qxmd.com/read/38498285/-89-zr-labeled-immunopet-targeting-the-cancer-stem-cell-antigen-cd133-using-fully-human-antibody-constructs
#4
JOURNAL ARTICLE
Kevin Wyszatko, Nancy Janzen, Luis Rafael Silva, Luke Kwon, Teesha Komal, Manuela Ventura, Chitra Venugopal, Sheila K Singh, John F Valliant, Saman Sadeghi
BACKGROUND: Cancer stem cells play an important role in driving tumor growth and treatment resistance, which makes them a promising therapeutic target to prevent cancer recurrence. Emerging cancer stem cell-targeted therapies would benefit from companion diagnostic imaging probes to aid in patient selection and monitoring response to therapy. To this end, zirconium-89-radiolabeled immunoPET probes that target the cancer stem cell-antigen CD133 were developed using fully human antibody and antibody scFv-Fc scaffolds...
March 18, 2024: EJNMMI Research
https://read.qxmd.com/read/38472569/evidence-of-brain-metabolism-redistribution-from-neocortex-to-primitive-brain-structures-in-early-acute-covid-19-respiratory-syndrome
#5
JOURNAL ARTICLE
Stephan P M Souza, Nicoli Colet, Mariana Fujiwara, Alins P Fernandes, Natalia Tobar, Sergio S J Dertkigil, Maria Emilia S Takahashi, Bárbara J Amorim, Lucas S Silva, Clarissa L Yasuda, Fernando Cendes, Thiago F de Souza, Juliano T Rodrigues, Denise E Zantut-Wittmann, Celso Dario Ramos
BACKGROUND: Neuropsychiatric sequelae of COVID-19 have been widely documented in patients with severe neurological symptoms during the chronic or subacute phase of the disease. However, it remains unclear whether subclinical changes in brain metabolism can occur early in the acute phase of the disease. The aim of this study was to identify and quantify changes in brain metabolism in patients hospitalized for acute respiratory syndrome due to COVID-19 with no or mild neurological symptoms...
March 12, 2024: EJNMMI Research
https://read.qxmd.com/read/38453813/evaluation-of-the-theranostic-potential-of-64-cu-cucl-2-in-glioblastoma-spheroids
#6
JOURNAL ARTICLE
Catarina I G Pinto, André D M Branco, Sara Bucar, Alexandra Fonseca, Antero J Abrunhosa, Cláudia L da Silva, Joana F Guerreiro, Filipa Mendes
BACKGROUND: Glioblastoma is an extremely aggressive malignant tumor with a very poor prognosis. Due to the increased proliferation rate of glioblastoma, there is the development of hypoxic regions, characterized by an increased concentration of copper (Cu). Considering this, 64 Cu has attracted attention as a possible theranostic radionuclide for glioblastoma. In particular, [64 Cu]CuCl2 accumulates in glioblastoma, being considered a suitable agent for positron emission tomography. Here, we explore further the theranostic potential of [64 Cu]CuCl2 , by studying its therapeutic effects in advanced three-dimensional glioblastoma cellular models...
March 7, 2024: EJNMMI Research
https://read.qxmd.com/read/38453724/improving-multi-pinhole-czt-myocardial-perfusion-imaging-specificity-without-changing-sensibility-by-using-adapted-filter-parameters
#7
JOURNAL ARTICLE
Fabien Vauchot, Julien Dubois, Aurélie Bourdon
BACKGROUND: Meta-analysis show the diagnostic performance of cardiac dedicated multi-pinhole cadmium-zinc-telluride myocardial perfusion imaging (MPI) with a sensibility around 0.9 and a specificity around 0.7. The aim of the present study is to explore a simple method to generate less artefact on MPI using single photon emission computed tomography (SPECT) and to enhance specificity without changing sensibility. RESULTS: From October 2018 to March 2019, 200 patients who underwent SPECT with [99m Tc]Tc-tetrofosmin were prospectively recruited: 100 patients with ischemia or necrosis diagnosis (first arm), and 100 patients with myocardial reversible SPECT artefact (second arm)...
March 7, 2024: EJNMMI Research
https://read.qxmd.com/read/38446249/glial-reactivity-in-a-mouse-model-of-beta-amyloid-deposition-assessed-by-pet-imaging-of-p2x7-receptor-and-tspo-using-11-c-smw139-and-18-f-f-dpa
#8
JOURNAL ARTICLE
Obada M Alzghool, Richard Aarnio, Jatta S Helin, Saara Wahlroos, Thomas Keller, Markus Matilainen, Junel Solis, Jonathan J Danon, Michael Kassiou, Anniina Snellman, Olof Solin, Juha O Rinne, Merja Haaparanta-Solin
BACKGROUND: P2X7 receptor has emerged as a potentially superior PET imaging marker to TSPO, the gold standard for imaging glial reactivity. [11 C]SMW139 is the most recently developed radiotracer to image P2X7 receptor. The aim of this study was to image reactive glia in the APP/PS1-21 transgenic (TG) mouse model of Aβ deposition longitudinally using [11 C]SMW139 targeting P2X7 receptor and to compare tracer uptake to that of [18 F]F-DPA targeting TSPO at the final imaging time point...
March 6, 2024: EJNMMI Research
https://read.qxmd.com/read/38436824/dynamic-whole-body-18-f-fes-pet-ct-increases-lesion-visibility-in-patients-with-metastatic-breast-cancer
#9
JOURNAL ARTICLE
Mette A Pedersen, Ole L Munk, André H Dias, Johanne H Steffensen, Anders L Møller, Anna Lyhne Johnsson, Kim Vang Hansen, Dirk Bender, Steen Jakobsen, Morten Busk, Lars C Gormsen, Trine Tramm, Signe Borgquist, Mikkel H Vendelbo
BACKGROUND: Correct classification of estrogen receptor (ER) status is essential for prognosis and treatment planning in patients with breast cancer (BC). Therefore, it is recommended to sample tumor tissue from an accessible metastasis. However, ER expression can show intra- and intertumoral heterogeneity. 16α-[18 F]fluoroestradiol ([18 F]FES) Positron Emission Tomography/Computed Tomography (PET/CT) allows noninvasive whole-body (WB) identification of ER distribution and is usually performed as a single static image 60 min after radiotracer injection...
March 4, 2024: EJNMMI Research
https://read.qxmd.com/read/38429609/significant-reduction-of-activity-retention-in-the-kidneys-via-optimized-linker-sequences-in-radiohybrid-based-minigastrin-analogs
#10
JOURNAL ARTICLE
Nadine Holzleitner, Sebastian Fischer, Isabel Maniyankerikalam, Roswitha Beck, Constantin Lapa, Hans-Jürgen Wester, Thomas Günther
BACKGROUND: We recently introduced radiohybrid (rh)-based minigastrin analogs e.g., DOTA-rhCCK-18 (DOTA-D-Dap(p-SiFA)-(D-γ-Glu)8 -Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH2 ), that revealed substantially increased activity retention in the tumor. However, one major drawback of these first generation rh-based cholecystokinin-2 receptor (CCK-2R) ligands is their elevated activity levels in the kidneys, especially at later time points (24 h p.i.). Therefore, this study aimed to reduce kidney retention with regard to a therapeutic use via substitution of negatively charged D-glutamic acid moieties by hydrophilic uncharged polyethylene glycol (PEG) linkers of various length ((PEG)4 to (PEG)11 )...
March 2, 2024: EJNMMI Research
https://read.qxmd.com/read/38424294/pharmacodynamics-and-biodistribution-of-195mpt-cisplatin-cisspect%C3%A2-in-head-and-neck-squamous-cell-carcinoma
#11
JOURNAL ARTICLE
Reinout H de Roest, Marijke Stigter van Walsum, Karlijn van der Schilden, Ruud H Brakenhoff
BACKGROUND: Cisplatin- based chemoradiotherapy is a crucial pillar in the treatment of HNSCC. The use of cisplatin comes with high toxicity rates as 35% of patients cannot sustain the planned dose while response is unpredictable. Unfortunately, there are no clinically applicable biomarkers to predict response. Based on the association of response with the number of DNA adducts and the involved molecular pathway to resolve cisplatin-induced DNA crosslinks in HNSCC, [195mPt]cisplatin (CISSPECT®) might have potential to monitor drug uptake and retention before treatment, and predict cisplatin response...
March 1, 2024: EJNMMI Research
https://read.qxmd.com/read/38409511/the-efficacy-of-short-acquisition-time-using-18-f-fdg-total-body-pet-ct-for-the-identification-of-pediatric-epileptic-foci
#12
JOURNAL ARTICLE
Min Li, Xiao Cui, Huixin Yue, Chao Ma, Kun Li, Leiying Chai, Min Ge, Hui Li, Yee Ling Ng, Yun Zhou, Jianguo Shi, Yanhua Duan, Zhaoping Cheng
BACKGROUND: 18 F-FDG positron emission tomography (PET) plays a crucial part in the evaluation for pediatric epileptic patients prior to therapy. Short-term scanning holds significant importance, especially for pediatrics epileptic individuals who exhibited involuntary movements. The aim was to evaluate the effects of short acquisition time on image quality and lesion detectability in pediatric epileptic patients using total-body (TB) PET/CT. A total of 25 pediatric patients who underwent TB PET/CT using uEXPLORER scanner with an 18 F-FDG administered dose of 3...
February 26, 2024: EJNMMI Research
https://read.qxmd.com/read/38372908/evaluation-of-therapeutic-effect-and-prognostic-value-of-18-f-fdg-pet-ct-in-different-treatment-nodes-of-dlbcl-patients
#13
JOURNAL ARTICLE
Wenyu Zhao, Xiaodong Wu, Shuo Huang, Hui Wang, Hongliang Fu
BACKGROUND: In the present study, we aimed to investigate the role of baseline (B), interim (I) and end-of-treatment (Eot) 18 F-FDG PET/CT in assessing the prognosis of diffuse large B cell lymphoma (DLBCL), so as to identify patients who need intensive treatment at an early stage. METHODS: A total of 127 DLBCL patients (62 men; 65 women; median age 62 years) were retrospectively analyzed in this study. Baseline (n = 127), interim (n = 127, after 3-4 cycles) and end-of-treatment (n = 53, after 6-8 cycles) PET/CT images were re-evaluated; semi-quantitative parameters such as maximum standardized uptake value of lesion-to-liver ratio (SUVmax(LLR) ) and lesion-to-mediastinum ratio (SUVmax(LMR) ), total metabolic tumor volume (TMTV) and total metabolic tumor volume (TLG) were recorded...
February 19, 2024: EJNMMI Research
https://read.qxmd.com/read/38363422/synthesis-and-preclinical-evaluation-of-11-c-eai045-as-a-pet-tracer-for-imaging-tumors-expressing-mutated-epidermal-growth-factor-receptor
#14
JOURNAL ARTICLE
Antonia A Högnäsbacka, Alex J Poot, Christophe Plisson, Jonas Bergare, David R Bonsall, Stuart P McCluskey, Lisa A Wells, Esther Kooijman, Robert C Schuit, Mariska Verlaan, Wissam Beaino, Guus A M S van Dongen, Danielle J Vugts, Charles S Elmore, Jan Passchier, Albert D Windhorst
BACKGROUND: Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding pocket, thereby inhibiting the receptor's function. However, subsequent treatment resistance mutations in the ATP binding site are common. The EGFR allosteric inhibitor, EAI045, is proposed to have an alternative mechanism of action, disrupting receptor signaling independent of the ATP-binding site...
February 16, 2024: EJNMMI Research
https://read.qxmd.com/read/38358425/non-specific-irreversible-89-zr-mab-uptake-in-tumours-evidence-from-biopsy-proven-target-negative-tumours-using-89-zr-immuno-pet
#15
JOURNAL ARTICLE
Jessica E Wijngaarden, Yvonne W S Jauw, Gerben J C Zwezerijnen, Berlinda J de Wit-van der Veen, Daniëlle J Vugts, Josée M Zijlstra, Guus A M S van Dongen, Ronald Boellaard, C Willemien Menke-van der Houven van Oordt, Marc C Huisman
BACKGROUND: Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89 Zr-mAb uptake on PET. Target-specific binding in tumours is of main interest; however, non-specific irreversible uptake may also be present, which influences quantification. The aim was to investigate the presence of non-specific irreversible uptake in tumour tissue using Patlak linearization on 89 Zr-immuno-PET data of biopsy-proven target-negative tumours. Data of two studies, including target status obtained from biopsies, were retrospectively analysed, and Patlak linearization provided the net rate of irreversible uptake (Ki )...
February 15, 2024: EJNMMI Research
https://read.qxmd.com/read/38340184/relaxed-fibronectin-a-potential-novel-target-for-imaging-endometriotic-lesions
#16
JOURNAL ARTICLE
Belinda Trachsel, Stefan Imobersteg, Giulia Valpreda, Gad Singer, Regula Grabherr, Mark Ormos, Irene A Burger, Rahel A Kubik-Huch, Roger Schibli, Viola Vogel, Martin Béhé
BACKGROUND: Endometriosis is characterized by the ectopic occurrence of endometrial tissue. Though considered benign, endometriotic lesions possess tumor-like properties such as tissue invasion and remodeling of the extracellular matrix. One major clinical hurdle concerning endometriosis is its diagnosis. The diagnostic modalities ultrasound and MRI are often unable to detect all lesions, and a clear correlation between imaging and clinical symptoms is still controversial. Therefore, it was our aim to identify a potential target to image active endometriotic lesions...
February 10, 2024: EJNMMI Research
https://read.qxmd.com/read/38324108/spherization-indices-measured-by-resting-spect-improve-risk-stratification-in-patients-with-ischemia-with-non-obstructive-coronary-artery-disease-inoca
#17
JOURNAL ARTICLE
Yuting Zhao, Yingqi Hu, Yuanyuan Li, Yanhui Wang, Yuxin Xiao, Li Xu, Tailin Ren, Qiuyan Wu, Ruonan Wang, Zhifang Wu, Sijin Li, Ping Wu
BACKGROUND: The prevalence of ischemia with non-obstructive coronary artery disease (INOCA) is substantial, but its risk stratification has been suboptimal. Resting SPECT myocardial perfusion imaging (MPI) could provide useful heart information including spherical indices. We aimed to evaluate the prognostic value of spherical indices in individuals with INOCA. RESULTS: During a median follow-up of 47.2 ± 20.8 months, 49 (17.2%) patients experienced major adverse cardiac events (MACE)...
February 7, 2024: EJNMMI Research
https://read.qxmd.com/read/38324095/exploring-the-impact-of-pegylation-on-pharmacokinetics-a-size-dependent-effect-of-polyethylene-glycol-on-prostate-specific-membrane-antigen-inhibitors
#18
JOURNAL ARTICLE
Yang Liu, Li Xia, Haiyang Li, Ping Cai, Sufan Tang, Yue Feng, Guangfu Liu, Yue Chen, Nan Liu, Wei Zhang, Zhijun Zhou
BACKGROUND: Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer-related deaths in men. Prostate-specific membrane antigen (PSMA) as a target has gained increasing attention. This research aims to investigate and understand how altering size of PEG impacts the in vitro and in vivo behavior and performance of PSMA inhibitors, with a specific focus on their pharmacokinetic characteristics and targeting properties. RESULTS: Two 68 Ga-labeled PSMA-targeted radiotracers were developed, namely [68 Ga]Ga-PP4-WD and [68 Ga]Ga-PP8-WD, with varying sizes of polyethylene glycol (PEG)...
February 7, 2024: EJNMMI Research
https://read.qxmd.com/read/38319478/risk-of-treatment-altering-haematological-toxicity-and-its-dependence-on-bone-marrow-doses-in-peptide-receptor-radionuclide-therapy
#19
JOURNAL ARTICLE
Märta Persson, Cecilia Hindorf, Oscar Ardenfors, Martin Larsson, Joachim N Nilsson
BACKGROUND: Peptide receptor radionuclide therapy is effective in treating neuroendocrine tumours, but treatment may be limited by kidney and bone marrow toxicity. In this work, the absorbed dose burden to the bone marrow was estimated using image-based dosimetry and its potential use for predicting treatment-altering toxicity was studied. Peripheral blood samples taken before and after 229 treatments with 177 Lu-DOTATATE in 59 patients were studied. In connection to the treatments, a total of 940 blood sample occasions provided data on white blood cell, neutrophil granulocyte, platelet, erythrocyte and haemoglobin concentrations...
February 6, 2024: EJNMMI Research
https://read.qxmd.com/read/38319452/the-image-quality-and-feasibility-of-solitary-delayed-68-%C3%A2-ga-ga-psma-11-pet-ct-using-long-field-of-view-scanning-in-patients-with-prostate-cancer
#20
JOURNAL ARTICLE
Xiaofeng Yu, Lian Xu, Gang Huang, Jianjun Liu, Ruohua Chen, Yumei Chen
BACKGROUND: Previous studies have demonstrated that delayed [68  Ga]Ga-PSMA PET/CT imaging improves lesion detection compared to early [68  Ga]Ga-PSMA PET/CT in patients with prostate cancer. However, the sole use of delayed [68  Ga]Ga-PSMA PET/CT has been limited due to the insufficient number of photons obtained with standard PET/CT scanners. The combination of early and delayed [68  Ga]Ga-PSMA standard PET/CT may be considered, and it is challenging to incorporate into a high-demand clinical setting...
February 6, 2024: EJNMMI Research
journal
journal
43586
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.