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EJNMMI Research

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https://www.readbyqxmd.com/read/27896673/the-clinical-safety-biodistribution-and-internal-radiation-dosimetry-of-18-f-ah113804-in-healthy-adult-volunteers
#1
E J Somer, R Owenius, A Wall, G Antoni, A Thibblin, J Sörensen
BACKGROUND: Quantitative biodistribution, venous blood and excretion data have been obtained following the intravenous bolus injection of AH113804 ((18)F) Injection in six healthy volunteers (HVs), four males and two females, up to approximately 5 h post-injection. For each subject, key organs and tissues were delineated and analytical fits were made to the image data as functions of time to yield the normalised cumulated activities. These were input to an internal radiation dosimetry calculation based upon the Medical Internal Radiation Dose (MIRD) schema for the Cristy-Eckerman adult male or female phantom...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27888500/the-effect-of-isoflurane-on-18-f-fdg-uptake-in-the-rat-brain-a-fully-conscious-dynamic-pet-study-using-motion-compensation
#2
Matthew G Spangler-Bickell, Bart de Laat, Roger Fulton, Guy Bormans, Johan Nuyts
BACKGROUND: In preclinical positron emission tomography (PET) studies an anaesthetic is used to ensure that the animal does not move during the scan. However, anaesthesia may have confounding effects on the drug or tracer kinetics under study, and the nature of these effects is usually not known. METHOD: We have implemented a protocol for tracking the rigid motion of the head of a fully conscious rat during a PET scan and performing a motion compensated list-mode reconstruction of the data...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27885618/pre-clinical-quantitative-imaging-and-mouse-specific-dosimetry-for-111-in-labelled-radiotracers
#3
Ana M Denis-Bacelar, Sarah E Cronin, Chiara Da Pieve, Rowena L Paul, Sue A Eccles, Terence J Spinks, Carol Box, Adrian Hall, Jane K Sosabowski, Gabriela Kramer-Marek, Glenn D Flux
BACKGROUND: Accurate quantification in molecular imaging is essential to improve the assessment of novel drugs and compare the radiobiological effects of therapeutic agents prior to in-human studies. The aim of this study was to investigate the challenges and feasibility of pre-clinical quantitative imaging and mouse-specific dosimetry of (111)In-labelled radiotracers. Attenuation, scatter and partial volume effects were studied using phantom experiments, and an activity calibration curve was obtained for varying sphere sizes...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27873241/predictive-factors-of-18-f-choline-pet-ct-positivity-in-patients-with-prostate-cancer-recurrence-after-radiation-therapy-is-the-impact-of-psa-nadir-underestimated
#4
Alison C Johnson, Audrey Emmanuelle Dugué, Marlon Silva, Laura Moise, Xavier Tillou, Florence Joly, Nicolas Aide
BACKGROUND: The objective of this study is to explore the impact of PSA nadirs on detection rates of prostate cancer (PCa) recurrence with (18)F-choline (CH) PET/CT after external beam radiation therapy (EBRT). METHODS: In this retrospective study, data were collected from 54 patients with suspicion of PCa biochemical recurrence after EBRT (28 patients treated initially with EBRT and 26 as salvage therapy in the absence of PSA decrease after initial treatment), who underwent (18)F-CH PET/CT between 2010 and 2015...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27873240/improved-safety-and-efficacy-of-213-bi-dotatate-targeted-alpha-therapy-of-somatostatin-receptor-expressing-neuroendocrine-tumors-in-mice-pre-treated-with-l-lysine
#5
Ho Sze Chan, Mark W Konijnenberg, Tamara Daniels, Monique Nysus, Mehran Makvandi, Erik de Blois, Wouter A Breeman, Robert W Atcher, Marion de Jong, Jeffrey P Norenberg
BACKGROUND: Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with (177)Lu-DOTATATE or (90)Y-DOTATOC has shown dose-limiting nephrotoxicity due to radiopeptide retention in the proximal tubules. Pharmacological protection can reduce renal uptake of radiopeptides, e.g., positively charged amino acids, to saturate in the proximal tubules, thereby enabling higher radioactivity to be safely administered...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27873239/effects-of-acetaminophen-on-mitochondrial-complex-i-activity-in-the-rat-liver-and-kidney-a-pet-study-with-18-f-bcpp-bf
#6
Hiroyuki Ohba, Masakatsu Kanazawa, Takeharu Kakiuchi, Hideo Tsukada
BACKGROUND: In the present study, 2-tert-butyl-4-chloro-5-[6-(4-(18)F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one ((18)F-BCPP-BF), a PET probe for mitochondrial complex I (MC-I), was used to validate whether MC-I is a useful biomarker for detecting acetaminophen-induced dysfunctions in the liver and kidney. The kinetic and distribution of (18)F-BCPP-BF were assessed in rats using high-resolution animal PET in vivo. The binding specificity of (18)F-BCPP-BF to MC-I in the liver and kidney was confirmed by the pre-administration of rotenone, a specific MC-I inhibitor...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27854031/evaluation-of-18-f-fluorothymidine-positron-emission-tomography-18-f-flt-pet-ct-methodology-in-assessing-early-response-to-chemotherapy-in-patients-with-gastro-oesophageal-cancer
#7
R Sharma, P Mapelli, G B Hanna, R Goldin, D Power, A Al-Nahhas, S Merchant, R Ramaswami, A Challapalli, T Barwick, E O Aboagye
BACKGROUND: 3'-Deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) PET has limited utility in abdominal imaging due to high physiological hepatic uptake of a tracer. We evaluated [(18)F]FLT-PET/CT combined with a temporal-intensity information-based voxel-clustering approach termed kinetic spatial filtering (KSF) to improve tumour visualisation in patients with locally advanced and metastatic gastro-oesophageal cancer and as a marker of early response to chemotherapy. Dynamic [(18)F]FLT-PET/CT data were collected before and 3 weeks post first cycle of chemotherapy...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27826950/effects-of-common-anesthetic-agents-on-18-f-flumazenil-binding-to-the-gabaa-receptor
#8
Mikael Palner, Corinne Beinat, Sam Banister, Francesca Zanderigo, Jun Hyung Park, Bin Shen, Trine Hjoernevik, Jae Ho Jung, Byung Chul Lee, Sang Eun Kim, Lawrence Fung, Frederick T Chin
BACKGROUND: The availability of GABAA receptor binding sites in the brain can be assessed by positron emission tomography (PET) using the radioligand, [(18)F]flumazenil. However, the brain uptake and binding of this PET radioligand are influenced by anesthetic drugs, which are typically needed in preclinical imaging studies and clinical imaging studies involving patient populations that do not tolerate relatively longer scan times. The objective of this study was to examine the effects of anesthesia on the binding of [(18)F]flumazenil to GABAA receptors in mice...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27822900/reproducibility-of-18-f-fluoromisonidazole-intratumour-distribution-in-non-small-cell-lung-cancer
#9
Milan Grkovski, Jazmin Schwartz, Andreas Rimner, Heiko Schöder, Sean D Carlin, Pat B Zanzonico, John L Humm, Sadek A Nehmeh
BACKGROUND: Hypoxic tumours exhibit increased resistance to radiation, chemical, and immune therapies. (18)F-fluoromisonidazole (FMISO) positron emission tomography (PET) is a non-invasive, quantitative imaging technique used to evaluate the presence and spatial distribution of tumour hypoxia. To facilitate the use of FMISO PET for identification of individuals likely to benefit from hypoxia-targeted treatments, we investigated the reproducibility of FMISO PET spatiotemporal intratumour distribution in patients with non-small cell lung cancer (NSCLC)...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27785766/impact-of-68-ga-psma-pet-ct-on-salvage-radiotherapy-planning-in-patients-with-prostate-cancer-and-persisting-psa-values-or-biochemical-relapse-after-prostatectomy
#10
Christina Bluemel, Fraenze Linke, Ken Herrmann, Iva Simunovic, Matthias Eiber, Christian Kestler, Andreas K Buck, Andreas Schirbel, Thorsten A Bley, Hans-Juergen Wester, Daniel Vergho, Axel Becker
BACKGROUND: Salvage radiotherapy (SRT) is clinically established in prostate cancer (PC) patients with PSA persistence or biochemical relapse (BCR) after prior radical surgery. PET/CT imaging prior to SRT may be performed to localize disease recurrence. The recently introduced (68)Ga-PSMA outperforms other PET tracers for detection of recurrence and is therefore expected also to impact radiation planning. Forty-five patients with PSA persistence (16 pts) or BCR (29 pts) after prior prostatectomy, scheduled to undergo SRT of the prostate bed, underwent (68)Ga-PSMA PET/CT...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27778311/cryopreservation-of-primary-human-monocytes-does-not-negatively-affect-their-functionality-or-their-ability-to-be-labelled-with-radionuclides-basis-for-molecular-imaging-and-cell-therapy
#11
Evangelia Pardali, Timo Schmitz, Andreas Borgscheiper, Janette Iking, Lars Stegger, Johannes Waltenberger
BACKGROUND: Circulating white blood cells crucially contribute to maintenance and repair of solid organs. Therefore, certain cell populations such as monocytes are attractive targets for use in molecular imaging and cell imaging, e.g. after labelling with radionuclides, as well as for cell therapies. However, the preparation of monocytes may require freezing and thawing to preserve cells for timely and standardised applications. Additional modifications of these cells such as radioisotope labelling are necessary prior to their application in vivo...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27771904/pilot-study-use-of-gallium-68-psma-pet-for-detection-of-metastatic-lesions-in-patients-with-renal-tumour
#12
Handoo Rhee, John Blazak, Chui Ming Tham, Keng Lim Ng, Benjamin Shepherd, Malcolm Lawson, John Preston, Ian Vela, Paul Thomas, Simon Wood
BACKGROUND: In this study, we prospectively evaluate the diagnostic potential of a gallium-68 (68Ga) prostate-specific membrane antigen (PSMA)-binding ligand and positron emission tomography (PET) in detecting metastatic lesions in patients with renal tumour. The secondary aim was to determine whether the findings would result in the alteration of patient management. RESULTS: Ten patients with renal lesion and potential metastatic disease on conventional imaging were recruited...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27757932/comparison-of-the-image-derived-radioactivity-and-blood-sample-radioactivity-for-estimating-the-clinical-indicators-of-the-efficacy-of-boron-neutron-capture-therapy-bnct-4-borono-2-18-f-fluoro-phenylalanine-fbpa-pet-study
#13
Kayako Isohashi, Eku Shimosegawa, Sadahiro Naka, Yasukazu Kanai, Genki Horitsugi, Ikuko Mochida, Keiko Matsunaga, Tadashi Watabe, Hiroki Kato, Mitsuaki Tatsumi, Jun Hatazawa
BACKGROUND: In boron neutron capture therapy (BNCT), positron emission tomography (PET) with 4-borono-2-(18)F-fluoro-phenylalanine (FBPA) is the only method to estimate an accumulation of (10)B to target tumor and surrounding normal tissue after administering (10)B carrier of L-paraboronophenylalanine and to search the indication of BNCT for individual patient. Absolute concentration of (10)B in tumor has been estimated by multiplying (10)B concentration in blood during BNCT by tumor to blood radioactivity (T/B) ratio derived from FBPA PET...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27726115/early-18-f-fdg-uptake-as-a-reliable-imaging-biomarker-of-t790m-mediated-resistance-but-not-met-amplification-in-non-small-cell-lung-cancer-treated-with-egfr-tyrosine-kinase-inhibitors
#14
Viviana De Rosa, Francesca Iommelli, Marcello Monti, Ciro Gabriele Mainolfi, Rosa Fonti, Silvana Del Vecchio
BACKGROUND: The two main mechanisms of resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) are the occurrence of T790M secondary mutation in the kinase domain of EGFR and MET amplification. The aim of the present study was to test whether early changes of (18)F-fluorodeoxyglucose ((18)F-FDG) uptake in animal models bearing erlotinib-resistant NSCLC may have different imaging patterns of response to erlotinib depending on the molecular mechanisms underlying resistance...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27709489/the-role-of-fdg-pet-ct-in-preoperative-staging-of-sentinel-lymph-node-biopsy-positive-melanoma-patients
#15
Evan C Frary, Dorte Gad, Lars Bastholt, Søren Hess
BACKGROUND: On April 1, 2015, Odense University Hospital (OUH) began a new diagnostic strategy, wherein all malignant melanoma (MM) patients in the Region of Southern Denmark with a positive sentinel lymph node biopsy (SLNB) underwent FDG-PET/CT preoperatively prior to lymph node dissection (LND). The purpose of this study is to determine FDG-PET/CT's efficacy in finding distant metastasis in the first year after the implementation of this new strategy, and to what extent these findings influence subsequent diagnostic testing and treatment in this patient group...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27678494/test-retest-analysis-of-a-non-invasive-method-of-quantifying-11-c-pbr28-binding-in-alzheimer-s-disease
#16
Akshay Nair, Mattia Veronese, Xiaohui Xu, Charles Curtis, Federico Turkheimer, Robert Howard, Suzanne Reeves
PURPOSE: In order to maximise the utility of [(11)C]-PBR28 for use in longitudinal studies and clinical trials in Alzheimer's disease (AD), there is a need to develop non-invasive metrics of tracer binding that do not require arterial cannulation. Recent work has suggested that standardised uptake value (SUV)-based methods may be sensitive to changes in translocator protein (TSPO) levels associated with neurodegeneration. However, the test-retest reliability of these approaches in AD over a time period relevant for clinical trials is unknown...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27655428/inter-observer-agreement-improves-with-percist-1-0-as-opposed-to-qualitative-evaluation-in-non-small-cell-lung-cancer-patients-evaluated-with-f-18-fdg-pet-ct-early-in-the-course-of-chemo-radiotherapy
#17
Joan Fledelius, Azza Khalil, Karin Hjorthaug, Jørgen Frøkiær
BACKGROUND: The purpose of this study is to determine whether a qualitative approach or a semi-quantitative approach provides the most robust method for early response evaluation with 2'-deoxy-2'-[(18)F]fluoro-D-glucose (F-18-FDG) positron emission tomography combined with whole body computed tomography (PET/CT) in non-small cell lung cancer (NSCLC). In this study eight Nuclear Medicine consultants analyzed F-18-FDG PET/CT scans from 35 patients with locally advanced NSCLC. Scans were performed at baseline and after 2 cycles of chemotherapy...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27655427/preclinical-evaluation-of-68-ga-nota-pentixafor-for-pet-imaging-of-cxcr4-expression-in-vivo%C3%A2-%C3%A2-a-comparison-to-68-ga-pentixafor
#18
Andreas Poschenrieder, Margret Schottelius, Markus Schwaiger, Hans-Jürgen Wester
BACKGROUND: Due to its overexpression in a variety of tumor types, the chemokine receptor 4 (CXCR4) represents a highly relevant diagnostic and therapeutic target in nuclear oncology. Recently, [(68)Ga]pentixafor has emerged as an excellent imaging agent for positron emission tomography (PET) of CXCR4 expression in vivo. In this study, the corresponding [(68)Ga]-1,4,7-triazacyclononane-triacetic acid (NOTA) analog was preclinically evaluated and compared to the 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) parent compound [(68)Ga]pentixafor...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27650281/-82-rb-pet-imaging-of-myocardial-blood-flow-have-we-achieved-the-4-r-s-to-support-routine-use
#19
EDITORIAL
Robert A deKemp, Ran Klein, Rob S B Beanlands
No abstract text is available yet for this article.
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27650280/quantification-of-myocardial-blood-flow-with-82-rb-validation-with-15-o-water-using-time-of-flight-and-point-spread-function-modeling
#20
Mary Germino, Jim Ropchan, Tim Mulnix, Kathryn Fontaine, Nabeel Nabulsi, Eric Ackah, Herman Feringa, Albert J Sinusas, Chi Liu, Richard E Carson
BACKGROUND: We quantified myocardial blood flow with (82)Rb PET using parameters of the generalized Renkin-Crone model estimated from (82)Rb and (15)O-water images reconstructed with time-of-flight and point spread function modeling. Previous estimates of rubidium extraction have used older-generation scanners without time-of-flight or point spread function modeling. We validated image-derived input functions with continuously collected arterial samples. METHODS: Nine healthy subjects were scanned at rest and under pharmacological stress on the Siemens Biograph mCT with (82)Rb and (15)O-water PET, undergoing arterial blood sampling with each scan...
December 2016: EJNMMI Research
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