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EJNMMI Research

Derrek A Heuveling, K Hakki Karagozoglu, Arthur Van Lingen, Otto S Hoekstra, Guus A M S Van Dongen, Remco De Bree
BACKGROUND: PET/CT lymphoscintigraphy using 89 Zr-nanocolloidal albumin has the potential to improve the preoperative identification of sentinel lymph nodes (SLNs), especially if located in the near proximity of the primary tumour. This study aims to demonstrate the feasibility of PET/CT lymphoscintigraphy followed by intraoperative detection of 89 Zr-nanocolloidal albumin containing SLNs with the use of a handheld high-energy gamma probe. METHODS: PET/CT lymphoscintigraphy was performed after peritumoural injection of 89 Zr-nanocolloidal albumin in five patients with oral cavity carcinoma planned for surgical resection...
February 14, 2018: EJNMMI Research
Richard Baumgartner, Aniket Joshi, Dai Feng, Francesca Zanderigo, R Todd Ogden
No abstract text is available yet for this article.
February 12, 2018: EJNMMI Research
Olivier Delcroix, Philippe Robin, Maelenn Gouillou, Alexandra Le Duc-Pennec, Zarrin Alavi, Pierre-Yves Le Roux, Ronan Abgral, Pierre-Yves Salaun, David Bourhis, Solène Querellou
BACKGROUND: xSPECT Bone® (xB) is a new reconstruction algorithm developed by Siemens® in bone hybrid imaging (SPECT/CT). A CT-based tissue segmentation is incorporated into SPECT reconstruction to provide SPECT images with bone anatomy appearance. The objectives of this study were to assess xB/CT reconstruction diagnostic reliability and accuracy in comparison with Flash 3D® (F3D)/CT in clinical routine. Two hundred thirteen consecutive patients referred to the Brest Nuclear Medicine Department for non-oncological bone diseases were evaluated retrospectively...
February 12, 2018: EJNMMI Research
Xinyu Chen, Rudolf A Werner, Constantin Lapa, Naoko Nose, Mitsuru Hirano, Mehrbod S Javadi, Simon Robinson, Takahiro Higuchi
BACKGROUND: 18F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (18F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover. RESULTS: Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies...
February 6, 2018: EJNMMI Research
Martin Mamach, Florian Wilke, Martin Durisin, Frank A Beger, Mareike Finke, Andreas Büchner, Barbara Schultz, Arthur Schultz, Lilli Geworski, Frank M Bengel, Thomas Lenarz, Anke Lesinski-Schiedat, Georg Berding
BACKGROUND: 15O-Water positron emission tomography (PET) enables functional imaging of the auditory system during stimulation via a promontory electrode or cochlear implant, which is not possible using functional magnetic resonance imaging (fMRI). Although PET has been introduced in this context decades ago, its feasibility when performed during general anesthesia has not yet been explored. However, due to a shift to earlier (and bilateral) auditory implantation, the need to study children during general anesthesia appeared, since they are not able to cooperate during scanning...
February 5, 2018: EJNMMI Research
J Soares Machado, J Tran-Gia, S Schlögl, A K Buck, M Lassmann
BACKGROUND: Renal scans are among the most frequent exams performed on infants and toddlers. Due to the young age, this patient group can be classified as a high-risk group with a higher probability for developing stochastic radiation effects compared to adults. As there are only limited data on biokinetics and dosimetry in this patient group, the aim of this study was to reassess the dosimetry and the associated radiation risk for infants undergoing 99mTc-MAG3 renal scans based on a retrospective analysis of existing patient data...
February 2, 2018: EJNMMI Research
Hojjat Ahmadzadehfar, Markus Essler
Radionuclide therapy, which until 15 years ago included only a few approved therapies, is gaining importance in the treatment of various malignancies. The future of oncology will not be limited to surgery, chemo-, antibody therapies or external radiation; it will include targeted therapy with radionuclides, which will become the standard of care for a variety of malignant diseases in combination or as an alternative to other therapies. Therefore there is a need to train Nuclear Oncologists, who are able to approach oncological diseases, promote development of radiopharmacy, understand the biology of radionuclide treatment, apply radionuclide treatments and be able to use molecular imaging such as PET/CT and SPECT/CT for treatment planning and dosimetry...
January 30, 2018: EJNMMI Research
Linn C Dobrowolski, Daan W Eeftinck Schattenkerk, C T Paul Krediet, Peter M Van Brussel, Liffert Vogt, Frederike J Bemelman, Jim A Reekers, Bert-Jan H Van Den Born, Hein J Verberne
BACKGROUND: Catheter-based renal sympathetic denervation (RDN) has been considered a potential treatment for therapy resistant hypertension (RHT). However, in a randomized placebo-controlled trial, RDN did not lead to a substantial blood pressure (BP) reduction. We hypothesized that variation in the reported RDN efficacy might be explained by incomplete nerve disruption as assessed by renal 123I-meta-iodobenzylguanidine (123I-mIBG) scintigraphy. METHODS: In 21 RHT patients (median age 60 years), we performed 123I-mIBG scintigraphy before and 6 weeks after RDN...
January 26, 2018: EJNMMI Research
K Binzel, A Adelaja, C L Wright, D Scharre, J Zhang, M V Knopp, E J Teoh, D Bottomley, A Scarsbrook, H Payne, A Afaq, J Bomanji, N van As, S Chua, P Hoskin, A Chambers, G J Cook, V S Warbey, A Chau, P Ward, M P Miller, D J Stevens, L Wilson, F V Gleeson, K Scheidhauer, C Seidl, M Autenrieth, F Bruchertseifer, C Apostolidis, F Kurtz, T Horn, C Pfob, M Schwaiger, J Gschwend, C D'Alessandria, A Morgenstern, C Uprimny, A Kroiss, C Decristoforo, E von Guggenberg, B Nilica, W Horninger, I Virgolini, S Rasul, N Poetsch, A Woehrer, M Preusser, M Mitterhauser, W Wadsak, G Widhalm, M Mischkulnig, M Hacker, T Traub-Weidinger, C L Wright, K Binzel, E J Wuthrick, E D Miller, P Maniawski, J Zhang, M V Knopp, Sebastijan Rep, Marko Hocevar, Janja Vaupotic, Urban Zdesar, Katja Zaletel, Luka Lezaic, S Mairinger, Thomas Filip, M Sauberer, S Flunkert, T Wanek, J Stanek, N Okamura, O Langer, C Kuntner, M C Fornito, R Balzano, V Di Martino, S Cacciaguerra, G Russo, D Seifert, M Kleinova, A Cepa, J Ralis, P Hanc, O Lebeda, M Mosa, S Vandenberghe, E Mikhaylova, D Borys, V Viswanath, M Stockhoff, N Efthimiou, P Caribe, R Van Holen, J S Karp, K Binzel, J Zhang, C L Wright, P Maniawski, M V Knopp, P M Haller, C Farhan, E Piackova, B Jäger, P Knoll, A Kiss, B K Podesser, J Wojta, K Huber, S Mirzaei, A Traxl, K Komposch, Elisabeth Glitzner, T Wanek, S Mairinger, M Sibilia, O Langer, M C Fornito, M Russello, G Russo, R Balzano, S Sorko, H J Gallowitsch, S Kohlfuerst, S Matschnig, M Rieser, M Sorschag, P Lind, L Ležaič, S Rep, J Žibert, N Frelih, S Šuštar, K Binzel, A Adelaja, C L Wright, D Scharre, J Zhang, M V Knopp, R P Baum, T Langbein, A Singh, M Shahinfar, C Schuchardt, G F Volk, H R Kulkarni, M C Fornito, S Cacciaguerra, R Balzano, G V Di Martino, G Russo, W H Thomson, M Kudlacek, M Karik, C Farhan, H Rieger, W Pokieser, K Glaser, S Mirzaei, V Petz, C Tugendsam, W Buchinger, B Schmoll-Hauer, I P Schenk, K Rudolph, M Krebs, G Zettinig, V Zoufal, T Wanek, M Krohn, S Mairinger, J Stanek, M Sauberer, T Filip, J Pahnke, O Langer, F Weitzer, B Pernthaler, S Salamon, R Aigner, P Koranda, L Henzlová, M Kamínek, Mo Váchalová, P Bachleda, D Summer, J Garousi, M Oroujeni, B Mitran, K G Andersson, A Vorobyeva, J N Löfblom, A Orlova, V Tolmachev, C Decristoforo, P Kaeopookum, D Summer, T Orasch, B Lechner, M Petrik, Z Novy, C Rangger, H Haas, C Decristoforo
No abstract text is available yet for this article.
January 23, 2018: EJNMMI Research
Charlotte A Porter, Kevin M Bradley, Eero T Hippeläinen, Matthew D Walker, Daniel R McGowan
BACKGROUND: Post-therapy SPECT/CT imaging of 90Y microspheres delivered to hepatic malignancies is difficult, owing to the continuous, high-energy Bremsstrahlung spectrum emitted by 90Y. This study aimed to evaluate the utility of a commercially available software package (HybridRecon, Hermes Medical Solutions AB) which incorporates full Monte Carlo collimator modelling. Analysis of image quality was performed on both phantom and clinical images in order to ultimately provide a recommendation of an optimum reconstruction for post-therapy 90Y microsphere SPECT/CT imaging...
January 22, 2018: EJNMMI Research
Yvonne W S Jauw, Marc C Huisman, Tapan K Nayak, Danielle J Vugts, Randolph Christen, Valerie Meresse Naegelen, Dominik Ruettinger, Florian Heil, Adriaan A Lammertsma, Henk M W Verheul, Otto S Hoekstra, Guus A M S van Dongen, C Willemien Menke-van der Houven van Oordt
BACKGROUND: Ideally, monoclonal antibodies provide selective treatment by targeting the tumour, without affecting normal tissues. Therefore, antibody imaging is of interest, preferably in early stages of drug development. However, the imaging signal consists of specific, as well as non-specific, uptake. The aim of this study was to assess specific, target-mediated uptake in normal tissues, with immuno-PET in a phase I dose escalation study, using the anti-CD44 antibody RG7356 as example...
January 22, 2018: EJNMMI Research
Aurora Crespo-Jara, Maria Carmen Redal-Peña, Elena Maria Martinez-Navarro, Manuel Sureda, Francisco Jose Fernandez-Morejon, Francisco J Garcia-Cases, Ramon Gonzalez Manzano, Antonio Brugarolas
BACKGROUND: Building a universal genomic signature predicting the intensity of FDG uptake in diverse metastatic tumors may allow us to understand better the biological processes underlying this phenomenon and their requirements of glucose uptake. METHODS: A balanced training set (n = 71) of metastatic tumors including some of the most frequent histologies, with matched PET/CT quantification measurements and whole human genome gene expression microarrays, was used to build the signature...
January 18, 2018: EJNMMI Research
Daniëlle Koopman, Jorn A van Dalen, Hester Arkies, Ad H J Oostdijk, Anne Brecht Francken, Jos Bart, Cornelis H Slump, Siert Knollema, Pieter L Jager
BACKGROUND: We evaluated the diagnostic implications of a small-voxel reconstruction for lymph node characterization in breast cancer patients, using state-of-the-art FDG-PET/CT. We included 69 FDG-PET/CT scans from breast cancer patients. PET data were reconstructed using standard 4 × 4 × 4 mm3 and small 2 × 2 × 2 mm3 voxels. Two hundred thirty loco-regional lymph nodes were included, of which 209 nodes were visualised on PET/CT. All nodes were visually scored as benign or malignant, and SUVmax and TBratio(=SUVmax/SUVbackground) were measured...
January 16, 2018: EJNMMI Research
Yong-Il Kim, Gi Jeong Cheon, Seo Young Kang, Jin Chul Paeng, Keon Wook Kang, Dong Soo Lee, June-Key Chung
BACKGROUND: The aim of this study was to determine the usefulness of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) parameters provided by simultaneous 18F-fluorodeoxyglucose (FDG) PET/MRI for the prediction of treatment failure in surgically resected head and neck cancer. We hypothesized that PET parameters corrected by tumor cellularity (combined PET/MRI parameters) could predict the prognosis. On regional PET, maximum standardized uptake value (SUVmax) was measured as metabolic parameters...
January 10, 2018: EJNMMI Research
J E Mongula, F C H Bakers, S Vöö, L Lutgens, T van Gorp, R F P M Kruitwagen, B F M Slangen
BACKGROUND: Advanced stage cervical cancer is primarily treated by radiotherapy. Local tumor control is a prerequisite for cure. Imaging after treatment is controversial. Positron emission tomography (PET) combined with computer tomography (PET-CT) shows great promise for detecting metastases. On the other hand, magnetic resonance imaging (MRI) is superior in depicting anatomical details. The combination of PET-MRI could result in more accurate evaluation of cervical cancer treatment outcome...
January 2, 2018: EJNMMI Research
Tunc Ones, Emel Eryuksel, Feyyaz Baltacioglu, Berrin Ceyhan, Tanju Yusuf Erdil
BACKGROUND: Selective internal radiation therapy (SIRT) with embolization of branches of the hepatic artery is a valuable therapeutic tool for patients with hepatic malignancies; however, it is also associated with lung injury risk due to shunting. Diffusion capacity of the lungs for carbon monoxide (DLCO) is a clinically significant lung function test, and worsening in DLCO is suggested to reflect a limited gas exchange reserve caused by the potential toxicity of chemoradiotherapy or it may be a marker of related lung injury...
December 29, 2017: EJNMMI Research
Keiko Matsunaga, Masahiro Yanagawa, Tomoyuki Otsuka, Haruhiko Hirata, Takashi Kijima, Atsushi Kumanogoh, Noriyuki Tomiyama, Eku Shimosegawa, Jun Hatazawa
BACKGROUND: Physiological measures per lung parenchyma, rather than per lung volume, sometimes reflect the disease status. PET images of the lung, which are usually expressed per lung volume, could confound the interpretation of the disease status, especially in cases with a prominent heterogeneity in aeration. The aim of the present study was to develop a method for measuring pulmonary blood flow (PBF) with aeration correction using 15O-H2O PET and to compare the results with those obtained using a conventional method...
December 22, 2017: EJNMMI Research
Edward Taylor, Jennifer Gottwald, Ivan Yeung, Harald Keller, Michael Milosevic, Neesha C Dhani, Iram Siddiqui, David W Hedley, David A Jaffray
BACKGROUND: The clinical impact of hypoxia in solid tumours is indisputable and yet questions about the sensitivity of hypoxia-PET imaging have impeded its uptake into routine clinical practice. Notably, the binding rate of hypoxia-sensitive PET tracers is slow, comparable to the rate of diffusive equilibration in some tissue types, including mucinous and necrotic tissue. This means that tracer uptake on the scale of a PET imaging voxel-large enough to include such tissue and hypoxic cells-can be as much determined by tissue transport properties as it is by hypoxia...
December 22, 2017: EJNMMI Research
Michael K O'Connor, Thuy D Tran, Tiffinee N Swanson, Lacey R Ellingson, Katie N Hunt, Dana H Whaley
BACKGROUND: Breast lesions closer than 2 cm to the chest wall are difficult to position in the field of view of dedicated breast PET (db-PET) systems. This inability to detect such lesions is a significant limitation of these systems. The primary objective of this study was to determine if modifications to the design of the imaging table and detector used for a db-PET system would enable improved visualization of breast tissue close to the chest wall. All studies were performed on a commercially available db-PET system (Mammi-PET)...
December 19, 2017: EJNMMI Research
Kathrin Heinzmann, Davina Jean Honess, David Yestin Lewis, Donna-Michelle Smith, Christopher Cawthorne, Heather Keen, Sandra Heskamp, Sonja Schelhaas, Timothy Howard Witney, Dmitry Soloviev, Kaye Janine Williams, Andreas Hans Jacobs, Eric Ofori Aboagye, John Richard Griffiths, Kevin Michael Brindle
Unfortunately, the original version of Figs. 4, 5 and 6b in the article [1] contained errors in the n numbers as indicated on the columns. Please note that column heights and error bars in the original figures and data in the ESM tables are correct and statistical tests are valid. These corrections do not affect any results or conclusions in this article.
December 15, 2017: EJNMMI Research
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