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Laboratory Animal Research

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https://www.readbyqxmd.com/read/29046705/super-pregnancy-in-a-balb-c-mouse-superovulated-with-pmsg
#1
Hanieh Vaseghi, Asghar Mogheiseh, Masood Sepehrimanesh, Mojtaba Kafi, Mohammad Hossein Nooranizadeh
This paper reports a case of super pregnancy in a BALB/c mouse pregnant with 30 pups following induction of superovulation using a PMSG-hCG protocol. Superovulation was induced in 10 mice by injecting 5 IU PMSG followed by 5 IU hCG 48 hours later. Immediately after injection of hCG, animals were placed with males at a ratio of 1 to 1 for 24 hours. On day 14 after mating, animals were killed by cervical dislocation and the uterus was examined for pregnancy and the number of fetuses. The mean (±SEM) number of fetuses observed in ten mice was 5...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046704/lipolytic-effect-of-novel-extracts-from-mulberry-morus-alba-leaves-fermented-with-cordyceps-militaris-in-the-primary-adipocytes-derived-from-sd-rats
#2
Mi Rim Lee, Ji Eun Kim, Woo Bin Yun, Jun Young Choi, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Young Whan Choi, Kyung Mi Kim, Dae Youn Hwang
Mulberry (Morus alba) leaves are known to have therapeutic effects on lipid metabolism including lipogenesis, lipolysis and hyperlipidemia. However, novel compounds with strong lipolytic ability among 27 extracts of the mulberry leaves fermented with Cordyceps militaris (EMfCs) have not yet been identified. Therefore, the cAMP concentration and cell viability were measured in the primary adipocytes of SD (Sprague Dawley) rats and 3T3-L1 cells after treatment of 27 EMfCs. Briefly, mulberry leaves powders amended with three different concentrations (0, 25 and 50%) of silkworm pupae (SWP) powder were fermented with 10% C...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046703/dose-dependent-effects-of-busulfan-on-dog-testes-in-preparation-for-spermatogonial-stem-cell-transplantation
#3
Tai-Young Hur, Seung-Hoon Lee, Sun-A Ock, Hyuk Song, Hyun-Jung Park, Ran Lee, Si-Heung Sung, Hyunjhung Jhun, Won-Young Lee
Successful male germ cell transplantation requires depletion of the host germ cells to allow efficient colonization of the donor spermatogonial stem cells. Although a sterilizing drug, busulfan, is commonly used for the preparation of recipient models before transplantation, the optimal dose of this drug has not yet been defined in dogs. In this study, 1-year-old mongrel dogs were intravenously injected with three different concentrations of busulfan (10, 15, or 17.5 mg/kg). Four weeks after busulfan treatment, no fully matured spermatozoa were detected in any of the busulfan-treated groups...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046702/in-vivo-validation-of-metastasis-regulating-microrna-766-in-human-triple-negative-breast-cancer-cells
#4
Keunhee Oh, Dong-Sup Lee
Breast cancer is the second most common cancer and the most frequent cancer in women worldwide. Recent improvements in early detection and effective adjuvant chemotherapies have improved the survival of breast cancer patients. Even with initial disease remission, one-third of all breast cancer patients will relapse with distant metastasis. Breast cancer metastasis is largely an incurable disease and the main cause of death among breast cancer patients. Cancer metastasis is comprised of complex processes that are usually not controllable by intervention of a single molecular target...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046701/safety-of-8-weeks-oral-administration-of-arctium-lappa-l
#5
So-Hyeon Bok, Seung Sik Cho, Chun-Sik Bae, Dae-Hun Park, Kyung-Mok Park
Recently, worldwide dietary reference intakes have been considered an important guideline for public health. Some governments and the World Health Organization (WHO) provide guidelines concerning dietary intake. Although an ingredient may have a history of use as a culinary material, changes in the environment over time suggest that the acceptable maximum intake each of food/culinary material should be regularly evaluated. Arctium lappa L. has been used as a culinary material for many centuries in Korea and Japan and some recent studies have reported related therapeutic effects...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046700/cerebral-ischemic-injury-decreases-%C3%AE-synuclein-expression-in-brain-tissue-and-glutamate-exposed-ht22-cells
#6
Phil-Ok Koh
α-Synuclein is abundantly expressed in neuronal tissue, plays an essential role in the pathogenesis of neurodegenerative disorders, and exerts a neuroprotective effect against oxidative stress. Cerebral ischemia causes severe neurological disorders and neuronal dysfunction. In this study, we examined α-synuclein expression in middle cerebral artery occlusion (MCAO)-induced cerebral ischemic injury and neuronal cells damaged by glutamate treatment. MCAO surgical operation was performed on male Sprague-Dawley rats, and brain samples were isolated 24 hours after MCAO...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046699/age-dependent-differences-in-myelin-basic-protein-expression-in-the-hippocampus-of-young-adult-and-aged-gerbils
#7
Ji Hyeon Ahn, Tae-Kyeong Lee, Joon Ha Park, Jeong Hwi Cho, In Hye Kim, Jae Chul Lee, Seongkweon Hong, Yong Hwan Jeon, Il Jun Kang, Young Joo Lee, Moo-Ho Won, Choong-Hyun Lee
Myelin degeneration is one of the characteristics of aging and degenerative diseases. This study investigated age-related alterations in expression of myelin basic protein (MBP) in the hippocampal subregions (dentate gyrus, CA2/3 and CA1 areas) of gerbils of various ages; young (1 month), adult (6 months) and aged (24 months), using western blot and immunohistochemistry. Western blot results showed tendencies of age-related reductions of MBP levels. MBP immunoreactivity was significantly decreased with age in synaptic sites of trisynaptic loops, perforant paths, mossy fibers, and Schaffer collaterals...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046698/evaluation-of-in-vitro-and-in-vivo-genotoxicity-of-angelica-acutiloba-in-a-standard-battery-of-assays
#8
Jun-Won Yun, Yun-Soon Kim, Euna Kwon, Seung-Hyun Kim, Ji-Ran You, Hyeon Hoe Kim, Jeong-Hwan Che, Byeong-Cheol Kang
Among three representative species of Angelica found in Asian countries, including Korea, China, and Japan, Angelica acutiloba (AA) has been used as traditional herbal medicine with antitumor, anti-inflammatory, anti-obesity, and anti-diabetes activities. In this study, the potential genotoxicity and mutagenicity of the AA extract were examined in a battery of in vitro and in vivo tests (bacterial reverse mutation assay, in vitro chromosomal aberrations assay, and in vivo micronucleus assay) in accordance with the test guidelines for toxicity testing developed by the Organization for Economic Cooperation and Development...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046697/preclinical-safety-assessment-of-angelica-acutiloba-using-a-13-week-repeated-dose-oral-toxicity-study-in-rats
#9
Jun-Won Yun, Euna Kwon, Seung-Hyun Kim, Ji-Ran You, Yun-Soon Kim, In Ae Park, Hyeon Hoe Kim, Jeong-Hwan Che, Byeong-Cheol Kang
Angelica acutiloba (AA), a Japanese species of Danggui, has been used worldwide as a traditional herbal medicine with several bioactivities including anti-diabetic, anti-allergic, anti-inflammatory, anti-tumor, and anti-obesity. However, there is lack of toxicological data available to evaluate potential long-term toxicity and the no-observed-adverse-effect level (NOAEL) of AA extract in accordance with the test guidelines published by the Organization for Economic Cooperation and Development. In the 14-day repeat-dose toxicity study, no adverse effects on mortality, body weight change, clinical signs, and organ weights was found following repeat oral administration to rats for 14 days (125, 250, 500, 1000, and 2000 mg/kg body weight), leading that 2000 mg/kg is the highest recommended dose of AA extract for the 13-week repeat-dose oral toxicity study...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046696/early-changes-in-retinal-structure-and-bmp2-expression-in-the-retina-and-crystalline-lens-of-streptozotocin-induced-diabetic-pigs
#10
Jae Seung Jeong, Woon-Kyu Lee, Yeon Sung Moon, Na Rae Kim
PURPOSE: This study aims to evaluate early changes in retinal structure and BMP2 expression in the retina and crystalline lens by comparing streptozotocin-induced diabetic pigs and normal control group pigs. METHODS: Five eye samples from five diabetic Micro-pigs (Medikinetics, Pyeongtaek, Korea) and five eye samples from five control pigs bred in a specific pathogen-free area were used. Diabetes was developed through intravenous injection of nicotinamide and streptozotocin, and the average fasting glucose level was maintained at 250 mg/dL or higher for 16 weeks...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046695/artemisia-argyi-attenuates-airway-inflammation-in-lipopolysaccharide-induced-acute-lung-injury-model
#11
Na-Rae Shin, Sung-Hyeuk Park, Je-Won Ko, Hyung-Won Ryu, Seong-Hun Jeong, Jong-Choon Kim, Dong-Ho Shin, Hoon-Sang Lee, In-Sik Shin
Artemisia argyi is used as a health supplement, tea, and food source in Korea. This study aimed to evaluate the effect of Artemisia argyi (AA) and its active compound, dehydromatricarin A (DA), on the attenuation of airway inflammation in a murine model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). The C57BL/6 mice were administered AA (50 mg/kg or 100 mg/kg) and DA (10 mg/kg or 20 mg/kg) by oral gavage from day 0 to 7 days and LPS treated by intranasal instillation 48 hours before the sacrifice...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046694/hyperglycemia-exacerbates-downregulation-of-dynamin-like-protein-1-in-ischemic-cerebral-injury
#12
Dong-Ju Park, Myeong-Ok Kim, Phil-Ok Koh
Ischemic stroke is one of the leading causes of adult disability and death. Hyperglycemia is associated with an increased risk of stroke and poor outcomes after brain injury. Dynamin-like protein I (DLP-1) regulates mitochondrial fission and promotes mitochondrial dynamics. Neurodegenerative diseases are associated with mitochondrial dysfunction, and the downregulation of DLP-1 has been previously identified in a stroke animal model. Here, we investigated the changes in DLP-1 protein expression in an animal model of focal cerebral ischemia with induced hyperglycemia...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046693/antibacterial-activity-of-essential-oil-from-lavender-lavandula-angustifolia-against-pet-turtle-borne-pathogenic-bacteria
#13
Sabrina Hossain, Honghoi Heo, B C J De Silva, S H M P Wimalasena, H N K S Pathirana, Gang-Joon Heo
Pet turtles are well-known to harbor an array of bacterial pathogens which can cause zoonotic infections in humans as well as opportunistic infections in the turtles itself. Essential oils are the natural plant extracts which have been traditionally used for disease treatment. In the present study, the essential oil of lavender (EOL) was examined for its antibacterial activity against thirty-eight strains of turtle-borne pathogenic bacteria belonging to seven species; Aeromonas hydrophila, A. caviae, A. dhakensis, Citrobacter freundii, Proteus mirabilis, Salmonella enterica and Pseudomonas aeruginosa...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747986/comparison-of-therapeutic-responses-to-an-anticancer-drug-in-three-stocks-of-icr-mice-derived-from-three-different-sources
#14
Ji Eun Sung, Ji Eun Kim, Hyun Ah Lee, Woo Bin Yun, Jun Young Choi, Mi Rim Lee, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Young Suk Jung, Kil Soo Kim, Dae Youn Hwang
Korl:ICR mice, established by the Korean National Institute of Food and Drug Safety Evaluation (NIFDS), are characterized based on their genetic variation, response to gastric injury, and response to constipation inducers. To compare the inhibitory responses of ICR stocks obtained from three different sources to the anticancer drug cisplatin (Cis), alterations in tumor volume, histopathological structure, and toxicity were examined in Sarcoma 180 tumor-bearing Korl:ICR, A:ICR (USA source), and B:ICR (Japan source) mice treated with low and high concentrations of Cis (L-Cis and H-Cis, respectively)...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747985/comparative-study-of-fertilization-rates-of-c57bl-6nkorl-and-c57bl-6n-mice-obtained-from-two-other-sources
#15
Woo Bin Yun, Hye Ryeong Kim, Ji Eun Kim, Jun Young Choi, Mi Rim Lee, Jin Ju Park, Bo Ram Song, Young Suk Jung, Hyun Keun Song, Joon Young Cho, Kil Soo Kim, Dae Youn Hwang
C57BL/6N is the most widely used inbred mouse strain applied in a wide variety of research areas including cancer, cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. To compare the fertilization rates of C57BL/6NKorl mice with two commercial C57BL/6N stocks, differences in reproductive organ structures, sperm and egg numbers, fertilization rates, and embryo development rates among C57BL/6NKorl (Korea FDA source), C57BL/6NA (USA source), and C57BL/6NB (Japan source) mice were determined...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747984/annual-tendency-of-research-papers-used-icr-mice-as-experimental-animals-in-biomedical-research-fields
#16
Ji Eun Kim, Jung Hoon Nam, Joon Young Cho, Kil Soo Kim, Dae Youn Hwang
Institute of Cancer Research (ICR) mice have been widely used in various research fields including toxicology, oncology, pharmacology, and pharmaceutical product safety testing for decades. However, annual tendency of research papers involving ICR mice in various biomedical fields has not been previously analyzed. In this study, we examined the numbers of papers that used ICR mice as experimental animals in the social science, natural science, engineering, medicine-pharmacy, marine agriculture-fishery, and art-kinesiology fields by analyzing big data...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747983/comparision-of-doxorubicin-induced-cardiotoxicity-in-the-icr-mice-of-different-sources
#17
Sou Hyun Kim, Keuk-Jun Kim, Joung-Hee Kim, Jae-Hwan Kwak, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim, Young-Suk Jung
Doxorubicin is a widely used chemotherapeutic agents and is now part of standard therapeutic regimens for a variety of cancers (eg, hematopoietic malignancies and advanced solid tumors of the breast, ovary, thyroid, and bone). However, a potentially lethal and dose-dependent cardiotoxicity that appears within a short time after treatment limits the usage of doxorubicin in cancer patients. Although the mechanism of doxorubicin-induced cardiotoxicity is not completely understood, it is thought that free radical-induced oxidative stress and excessive production of reactive oxygen species are primary drivers of its toxicity...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747982/comparative-study-of-fatty-liver-induced-by-methionine-and-choline-deficiency-in-c57bl-6n-mice-originating-from-three-different-sources
#18
Sou Hyun Kim, Yong Lim, Ju Bin Park, Jae-Hwan Kwak, Keuk-Jun Kim, Joung-Hee Kim, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim, Young-Suk Jung
Non-alcoholic fatty liver disease (NAFLD) is believed to be the most prevalent liver disease worldwide and a major cause of chronic liver injury. It is characterized by lipid accumulation in the absence of significant alcohol consumption and frequently progresses to steatohepatitis, liver fibrosis, and hepatocellular carcinoma. Although many studies have been conducted to better understand NAFLD since it was first recognized, there are still many gaps in knowledge of etiology, prognosis, prevention and treatment...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747981/comparison-of-the-response-using-icr-mice-derived-from-three-different-sources-to-multiple-low-dose-streptozotocin-induced-diabetes-mellitus
#19
Do Yeon Lee, Myeong Hwan Kim, Hye Rin Suh, Young Suk Jung, Dae Youn Hwang, Kil Soo Kim
This study was conducted to compare the multiple low-dose streptozotocin (MLDS)-induced diabetic patterns of Korl:ICR, A:ICR, and B:ICR mice obtained from three different sources. Six-week-old male ICR mice were obtained from three difference sources. Korl:ICR mice were kindly provided by the National Institute of Food and Drug Safety Evaluation (NIFDS). The other two groups of ICR mice were purchased from different vendors located in the United States (A:ICR) and Japan (B:ICR). All ICR mice that received MLDS exhibited overt diabetic symptoms throughout the study, and the incidence and development of diabetes mellitus were similar among the three ICR groups...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747980/comparative-analysis-of-basal-locomotor-activity-related-metabolic-phenotypes-between-c57bl-6-mice-and-icr-mice-substrains-derived-from-three-different-sources
#20
Dong-Ju Hwang, Hyun-Keun Song, Kil-Soo Kim, Young-Suk Jung, Dae-Youn Hwang, Joon Young Cho
Animal model, as an indispensable tool for scientific purposes of biomedical researches and clinical application, is a commonly used in various researches. Regarding to this, it is necessary to establish the metabolic phenotype of animal model to minimize spurious interpretations and ensure a level of accuracy and reliability adequate for experimental research. However, the metabolic phenotype-related analysis within rodent strains derived from different source is nonexistent, especially in C57BL/6Korl mice and Korl:ICR mice (a domestic mouse strain)...
June 2017: Laboratory Animal Research
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