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Laboratory Animal Research

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https://www.readbyqxmd.com/read/29628977/erratum-blood-flow-improving-activity-of-methyl-jasmonate-treated-adventitious-roots-of-mountain-ginseng
#1
Young-Hwan Ban, Yeseul Cha, Jieun Choi, Eun Suk An, Ji Young Lee, Nu Ry Han, Da Woom Seo, Gooyoung Jung, Da-Hye Jeong, Man Hee Rhee, Ehn-Kyoung Choi, Yun-Bae Kim
[This corrects the article on p. 105 in vol. 33, PMID: 28747975.].
March 2018: Laboratory Animal Research
https://www.readbyqxmd.com/read/29628976/anti-coccidial-activity-of-the-ethanol-extract-of-tribulus-terrestris-fruits-on-eimeria-tenella
#2
Sunhwa Hong, Mi-Na Moon, Eun-Kyung Im, Jum-Soon Won, Ji-Hyun Yoo, Okjin Kim
Anti-coccidial effects of the fruits of Tribulus terrestris (Tribuli fructus) ethanol extract (TTE) were studied with animal experiment following per oral administration with Eimeria ( E .) tenella . This experiment was performed on the 3-day-old chicks (n=30). The animals were divided with 3 groups; TFE 15mg per animal+infected (n=10), TTE untreated+infected (n=10) and non-infected control (n=10). Animals were administrated with or without TTE during 1 week, and then inoculated with E. tenella . The anti-coccidial activity were evaluated with oocysts shedding numbers in stools, body weights changes and food intake changes...
March 2018: Laboratory Animal Research
https://www.readbyqxmd.com/read/29628975/protective-effects-of-cultured-and-fermented-ginseng-extracts-against-scopolamine-induced-memory-loss-in-a-mouse-model
#3
Song-Hee Han, Sung-June Kim, Young Won Yun, Sang Yoon Nam, Hu-Jang Lee, Beom-Jun Lee
This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJG0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-week-old male ICR mice were used to evaluate the protective effect of HLJG0701 against the SPL-induced memory loss animal model. The Morris water maze test, which measures hippocampus-dependent learning ability, and the Y-maze test, a short-term memory assessment test, were performed and related markers were analyzed...
March 2018: Laboratory Animal Research
https://www.readbyqxmd.com/read/29628974/the-effect-of-near-infrared-fluorescence-conjugation-on-the-anti-cancer-potential-of-cetuximab
#4
Ji Young Yun, Byung-Hwa Hyun, Sang Yoon Nam, Young Won Yun, Hu-Jang Lee, Beom-Jun Lee
This study investigated the anti-cancer potential of a near-infrared fluorescence (NIRF) molecule conjugated with Cetuximab (Cetuximab-NIRF) in six-week-old female BALB/c athymic (nu+/nu+) nude mice. A431 cells were cultured and injected into the animals to induce solid tumors. Paclitaxel (30 mg/kg body weight (BW)), Cetuximab (1 mg/kg BW), and Cetuximab-NIRF (0.25, 0.5 and 1.0 mg/kg BW) were intraperitoneally injected twice a week into the A431 cell xenografts of the nude mice. Changes in BW, tumor volume and weight, fat and lean mass, and diameter of the peri-tumoral blood vessel were determined after two weeks...
March 2018: Laboratory Animal Research
https://www.readbyqxmd.com/read/29628973/higher-incidence-of-sperm-granuloma-in-the-epididymis-of-c57bl-6n-mice
#5
Do-Yong Park, Byoung-Seok Lee, Woo-Jin Kim, Wan-Jung Im, Ji-Seok Han, Heejin Park, Mi-Jin Yang, Jae-Woo Cho, Da Hee Kim, Su-Cheol Han, Yong-Bum Kim, Hwa-Young Son
C57BL/6N mice are inbred strains widely used in biomedical research. Hence, a large amount of basic data has been accumulated. However, in the field of histopathology, spontaneous data for relatively younger mice that are used more frequently are not yet abundant, in contrast to data for older mice and their neoplastic lesions. To acquire the essential background data required by various research and toxicological assessments, 120 mice of the C57BL/6N strain (10 and 13 weeks of age) were collected from two institutions (From Korea and Japan) and subjected to histopathological analyses of the major organs (liver, spleen, kidney, thymus, heart, testis, epididymis)...
March 2018: Laboratory Animal Research
https://www.readbyqxmd.com/read/29628972/ensuring-reproducibility-and-ethics-in-animal-experiments-reporting-in-korea-using-the-arrive-guideline
#6
Mi-Hyun Nam, Myung-Sun Chun, Je-Kyung Seong, Hoon-Gi Kim
The aim of this study is to evaluate the reporting quality of animal experiments in Korea using the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guideline developed in 2010 to overcome the reproducibility problem and to encourage compliance with replacement, refinement and reduction of animals in research (3R's principle). We reviewed 50 papers published by a Korean research group from 2013 to 2016 and scored the conformity with the 20-items ARRIVE guideline. The median conformity score was 39...
March 2018: Laboratory Animal Research
https://www.readbyqxmd.com/read/29628971/establishment-of-a-chronic-obstructive-pulmonary-disease-mouse-model-based-on-the-elapsed-time-after-lps-intranasal-instillation
#7
Soon-Young Lee, Jin-Ho Cho, Seung Sik Cho, Chun-Sik Bae, Gye-Yeop Kim, Dae-Hun Park
Chronic obstructive pulmonary disease (COPD) was the 3rd leading cause of death in 2012 worldwide. It is particularly severe in the elderly, who are at risk of death by coughing, mucous hypersecretion, and finally breathlessness. Recently, anti-COPD drug development has increased, and many animal screening systems have been studied. Tobacco smoke animal models are the best known animal screening system, but have several preparation requirements, such as a tobacco smoke generator and a separate facility to prevent smoke release...
March 2018: Laboratory Animal Research
https://www.readbyqxmd.com/read/29399035/erratum-comparative-study-of-fertilization-rates-of-c57bl-6nkorl-and-c57bl-6n-mice-obtained-from-two-other-sources
#8
Woo Bin Yun, Hye Ryeong Kim, Ji Eun Kim, Jun Young Choi, Mi Rim Lee, Jin Ju Park, Bo Ram Song, Young Suk Jung, Hyun Keun Song, Joon Young Cho, Kil Soo Kim, Dae Youn Hwang
[This corrects the article on p. 179 in vol. 33, PMID: 28747985.].
December 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29399034/erratum-annual-tendency-of-research-papers-used-icr-mice-as-experimental-animals-in-biomedical-research-fields
#9
Ji Eun Kim, Jung Hoon Nam, Joon Young Cho, Kil Soo Kim, Dae Youn Hwang
[This corrects the article on p. 171 in vol. 33, PMID: 28747984.].
December 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29399033/erratum-comparison-of-doxorubicin-induced-cardiotoxicity-in-the-icr-mice-of-different-sources
#10
Sou Hyun Kim, Keuk-Jun Kim, Joung-Hee Kim, Jae-Hwan Kwak, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim, Young-Suk Jung
[This corrects the article on p. 165 in vol. 33, PMID: 28747983.].
December 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29399032/erratum-comparative-study-of-fatty-liver-induced-by-methionine-and-choline-deficiency-in-c57bl-6n-mice-originating-from-three-different-sources
#11
Sou Hyun Kim, Yong Lim, Ju Bin Park, Jae-Hwan Kwak, Keuk-Jun Kim, Joung-Hee Kim, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim, Young-Suk Jung
[This corrects the article on p. 157 in vol. 33, PMID: 28747982.].
December 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29399031/erratum-comparative-analysis-of-basal-locomotor-activity-related-metabolic-phenotypes-between-c57bl-6-mice-and-icr-mice-substrains-derived-from-three-different-sources
#12
Dong-Ju Hwang, Hyun-Keun Song, Kil-Soo Kim, Young-Suk Jung, Dae-Youn Hwang, Joon Young Cho
[This corrects the article on p. 140 in vol. 33, PMID: 28747980.].
December 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29399030/erratum-comparison-of-humoral-and-cell-mediated-immunity-in-three-different-c57bl-6n-mouse-substrains
#13
Hye Ryeong Kim, Jun Young Choi, Kil Soo Kim, Young-Suk Jung, Joon Young Cho, Dae Youn Hwang, Hyun Keun Song
[This corrects the article on p. 132 in vol. 33, PMID: 28747979.].
December 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29399029/erratum-comparative-study-of-the-immunological-characteristics-of-three-different-c57bl-6n-mouse-substrains
#14
Jun Young Choi, Hye Ryeong Kim, Kil Soo Kim, Young-Suk Jung, Joon Young Cho, Dae Youn Hwang, Hyun Keun Song
[This corrects the article on p. 124 in vol. 33, PMID: 28747978.].
December 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29399028/quercetin-attenuates-the-injury-induced-reduction-of-%C3%AE-enolase-expression-in-a-middle-cerebral-artery-occlusion-animal-model
#15
Seong-Jun Jeon, Myeong-Ok Kim, Fawad Ali-Shah, Phil-Ok Koh
Quercetin, a natural flavonoid, copiously exists in vegetable, fruits and tea. Quercetin is beneficial to neurodegenerative disorders via its strong anti-oxidant and anti-inflammatory activities. γ-Enolase is one of the enzymes of glycolytic pathway and is predominantly expressed in neuronal cells. The aim of the present study is to verify whether quercetin modulates the expression of γ-enolase in brain ischemic injury. Adult Sprague-Dawley male rats were subjected to middle cerebral artery occlusion (MCAO) and quercetin (50 mg/kg) or vehicle was administered by intraperitoneal injection at 1 h before MCAO onset...
December 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29399027/correlation-between-laxative-effects-of-uridine-and-suppression-of-er-stress-in-loperamide-induced-constipated-sd-rats
#16
Ji Eun Kim, Bo Ram Song, Woo Bin Yun, Jun Young Choi, Jin Ju Park, Mi Rim Lee, Dae Youn Hwang
A correlation between endoplasmic reticulum (ER) stress and laxative effects was first reported in a constipation model treated with an aqueous extract of Liriope platyphylla (AEtLP) roots. To investigate the correlation between the laxative effect of uridine (Urd) and ER stress response, alterations in the key parameters for ER stress were measured in loperamide (Lop) induced constipation Sprague Dawley (SD) rats treated with Urd. The efficacy of the laxative effect of Urd was notable on the symptoms of chronic constipation, including alteration of stool parameters and structure of the transverse colon, in Lop induced constipated SD rats...
December 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29399026/gold-thread-implantation-promotes-hair-growth-in-human-and-mice
#17
Jong-Hwan Kim, Eun-Young Cho, Euna Kwon, Woo-Ho Kim, Jin-Sung Park, Yong-Soon Lee, Jun-Won Yun, Byeong-Cheol Kang
Thread-embedding therapy has been widely applied for cosmetic purposes such as wrinkle reduction and skin tightening. Particularly, gold thread was reported to support connective tissue regeneration, but, its role in hair biology remains largely unknown due to lack of investigation. When we implanted gold thread and Happy Lift™ in human patient for facial lifting, we unexpectedly found an increase of hair regrowth in spite of no use of hair growth medications. When embedded into the depilated dorsal skin of mice, gold thread or polyglycolic acid (PGA) thread, similarly to 5% minoxidil, significantly increased the number of hair follicles on day 14 after implantation...
December 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29399025/-dendropanax-morbifera-l%C3%A3-veille-extract-ameliorates-d-galactose-induced-memory-deficits-by-decreasing-inflammatory-responses-in-the-hippocampus
#18
Kwon Young Lee, Hyo Young Jung, Dae Young Yoo, Woosuk Kim, Jong Whi Kim, Hyun Jung Kwon, Dae Won Kim, Yeo Sung Yoon, In Koo Hwang, Jung Hoon Choi
In the present study, we examined the effects of Dendropanax morbifera Léveille leaf extract (DML) on D-galactose-induced morphological changes in microglia and cytokines, including pro-inflammatory cytokines (interleukin [IL]-1β, IL-6, and tumor necrosis factor [TNF]-α) and anti-inflammatory cytokines (IL-4 and IL-10) in the hippocampus. Administration of DML to D-galactose-treated mice significantly improved D-galactose-induced reduction in escape latency, swimming speed, and spatial preference for the target quadrant...
December 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046705/super-pregnancy-in-a-balb-c-mouse-superovulated-with-pmsg
#19
Hanieh Vaseghi, Asghar Mogheiseh, Masood Sepehrimanesh, Mojtaba Kafi, Mohammad Hossein Nooranizadeh
This paper reports a case of super pregnancy in a BALB/c mouse pregnant with 30 pups following induction of superovulation using a PMSG-hCG protocol. Superovulation was induced in 10 mice by injecting 5 IU PMSG followed by 5 IU hCG 48 hours later. Immediately after injection of hCG, animals were placed with males at a ratio of 1 to 1 for 24 hours. On day 14 after mating, animals were killed by cervical dislocation and the uterus was examined for pregnancy and the number of fetuses. The mean (±SEM) number of fetuses observed in ten mice was 5...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046704/lipolytic-effect-of-novel-extracts-from-mulberry-morus-alba-leaves-fermented-with-cordyceps-militaris-in-the-primary-adipocytes-derived-from-sd-rats
#20
Mi Rim Lee, Ji Eun Kim, Woo Bin Yun, Jun Young Choi, Jin Ju Park, Hye Ryeong Kim, Bo Ram Song, Young Whan Choi, Kyung Mi Kim, Dae Youn Hwang
Mulberry ( Morus alba ) leaves are known to have therapeutic effects on lipid metabolism including lipogenesis, lipolysis and hyperlipidemia. However, novel compounds with strong lipolytic ability among 27 extracts of the mulberry leaves fermented with Cordyceps militaris (EMfCs) have not yet been identified. Therefore, the cAMP concentration and cell viability were measured in the primary adipocytes of SD (Sprague Dawley) rats and 3T3-L1 cells after treatment of 27 EMfCs. Briefly, mulberry leaves powders amended with three different concentrations (0, 25 and 50%) of silkworm pupae (SWP) powder were fermented with 10% C...
September 2017: Laboratory Animal Research
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