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Laboratory Animal Research

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https://www.readbyqxmd.com/read/28053621/clinical-and-magnetic-resonance-imaging-features-of-compressive-cervical-myelopathy-with-traumatic-intervertebral-disc-herniation-in-cynomolgus-macaque-macaca-fascicularis
#1
Yun-Jung Choi, Hye-Jin Park, Chul-Ho Sohn, Kyeong Cheon Jung, Seong Hoe Park, Jae-Il Lee
Intervertebral disc herniation (IVDH) with nucleus pulposus extrusion, traumatic or not, is a devastating clinical condition accompanied by neurological problems. Here we report a cynomolgus macaque suffering from acute and progressive neurological dysfunction by a blunt trauma due to neck collar, an animal handling device. Tetraplegia, urinary incontinence, decreased proprioception, and imperception of pain were shown on physical and neurological examinations. MRI sagittal T2 weighted sequences revealed an extensive protrusion of disc material between C2 and C3 cervical vertebra, and this protrusion resulted in central stenosis of the spinal cord...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28053620/establishment-of-a-surgically-induced-cryptorchidism-canine-recipient-model-for-spermatogonial-stem-cell-transplantation
#2
Won-Young Lee, Ran Lee, Hyuk Song, Tai-Young Hur, Seunghoon Lee, Jiyun Ahn, Hyunjhung Jhun
Transplantation of spermatogonial stem cells (SSCs) in experimental animal models has been used to study germ line stem cell biology and to produce transgenic animals. The species-specific recipient model preparation is important for the characterization of SSCs and the production of offspring. Here, we investigated the effects of surgically induced cryptorchidism in dog as a new recipient model for spermatogonial stem cell transplantation. Artificially unilateral or bilateral cryptorchidism was induced in ten mature male dogs by surgically returning the testis and epididymis to the abdominal cavity...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28053619/overexpression-of-n141i-ps2-increases-%C3%AE-secretase-activity-through-up-regulation-of-presenilin-and-pen-2-in-brain-mitochondria-of-nse-hps2m-transgenic-mice
#3
Woo Bin Yun, Jin Ju Park, Ji Eun Kim, Ji Eun Sung, Hyun Ah Lee, Jae Ho Lee, Chang Jun Bae, Dae Youn Hwang
Alzheimer's disease (AD) is known to induce alterations of mitochondrial function such as elevation of oxidative stress and activation of apopotosis. The aim of this study was to investigate the effects of human Presenilin 2 mutant (hPS2m) overexpression on the γ-secretase complex in the mitochondrial fraction. To achieve this, alterations of γ-secretase complex expression and activity were detected in the mitochondrial fraction derived from brains of NSE/hPS2m Tg mice and Non-Tg mice. Herein, the following were observed: i) overexpression of the hPS2m gene significantly up-regulated the deposition of Aβ-42 peptides in the hippocampus and cortex of brain, ii) overexpression of hPS2m protein induced alterations of γ-secretase components such as main component protein and activator protein but not stabilization-related proteins, iii) changes in γ-secretase components induced by overexpression of hPS2m protein up-regulated γ-secretase activity in the mitochondrial fraction, and iv) elevation of γ-secretase activity induced production of Aβ-42 peptides in the mitochondrial fraction...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28053618/changes-of-hematological-references-depends-on-storage-period-and-temperature-conditions-in-rats-and-dogs
#4
Jung-Min Lee, Jin Seok Kang
Because changes in rat and dog hematological parameters according to storage conditions have been poorly documented, we sought to examine such changes. Blood analysis was performed using two hematology analyzers (ADVIA 2120i and Sysmex XN-V) after storage at room temperature and in cold storage for 5, 24, and 48 h, respectively. Interassay coefficients of variation for hematological parameters analyzed with the ADVIA 2120i and the XN-V showed similar. The levels of hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and platelet (PLT) showed significant variations with time in blood samples of rats and dogs...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28053617/characterization-the-response-of-korl-icr-mice-to-loperamide-induced-constipation
#5
Ji Eun Kim, Woo Bin Yun, Ji Eun Sung, Hyun Ah Lee, Jun Young Choi, Yeon Shik Choi, Young Suk Jung, Kil Soo Kim, Dae Youn Hwang
Animal models of constipation induced with drugs and diet have been widely employed to investigate therapeutic effects and the action mechanism of drugs against this disease. ICR mice were selected to produce this disease model through oral administration of loperamide (Lop), even though SD rats are commonly utilized in studies of constipation. To compare the responses of ICR mice obtained from three different sources to constipation inducers, alterations in stool number, histopathological structure, mucin secretion and opioid-receptor downstream signaling pathway were measured in Korl:ICR (Korea FDA source), A:ICR (USA source) and B:ICR (Japan source) injected with low and high concentrations of Lop (LoLop and HiLop)...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28053616/sirtuin-2-inhibition-affects-hippocampal-functions-and-sodium-butyrate-ameliorates-the-reduction-in-novel-object-memory-cell-proliferation-and-neuroblast-differentiation
#6
Hyo Young Jung, Dae Young Yoo, Jong Whi Kim, Dae Won Kim, Jung Hoon Choi, Jin Young Chung, Moo-Ho Won, Yeo Sung Yoon, In Koo Hwang
We investigated the effects of the sirtuin-2 (SIRT2) inhibitor AK-7 on novel object memory, cell proliferation, and neuroblast differentiation in the dentate gyrus. In addition, we also observed the relationships with sodium butyrate, a histone deacetylase inhibitor, on the hippocampal functions. To investigate the effects of AK-7 on hippocampal functions, 10-week-old C57BL/6 mice were daily injected intraperitoneally with 20 mg/kg AK-7 alone or in combination with subcutaneous administration of 300 mg/kg sodium butyrate, a histone deacetylase inhibitor, for 21 days...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28053615/antioxidant-and-hepatoprotective-effects-of-fermented-red-ginseng-against-high-fat-diet-induced-hyperlipidemia-in-rats
#7
Myeong-Hwan Kim, Eun-Jin Lee, Jeong-Mu Cheon, Ki-Jun Nam, Tae-Ho Oh, Kil-Soo Kim
This study was performed to investigate the antioxidant and hepatoprotective effects of fermented red ginseng (Panax ginseng C.A. Meyer; FRG) on high-fat diet-induced hyperlipidemia in rats. Sprague-Dawley rats were divided into four groups of seven: normal control, NC; high-fat diet control, HFC; high-fat diet-0.5% FRG, HF-FRGL; and high-fat diet-1% FRG, HF-FRGH. All rats were fed a high-fat diet for eight weeks, except those in the NC group, while rats in the FRG treatment groups received drinking water containing 0...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28053614/multilocus-sequence-typing-analysis-of-pseudomonas-aeruginosa-isolated-from-pet-chinese-stripe-necked-turtles-ocadia-sinensis
#8
Mitchell Wendt, Gang-Joon Heo
Our research sought to characterize the phylogeny of Pseudomonas aeruginosa isolated from pet Chinese stripe-necked turtles (Ocadia sinensis) to better understand its evolutionary relation to other isolates and increase understanding of a potential zoonotic pathogen transmitted through direct contact with pet turtles. Thirty-one Pseudomonas aeruginosa isolates were obtained from both immature and adult turtles sold in pet shops in Korea. To characterize the phylogenic position of Chinese stripe-necked turtle-borne P...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28053613/diallyl-disulfide-attenuates-acetaminophen-induced-renal-injury-in-rats
#9
Jin-Young Shin, Ji-Hee Han, Je-Won Ko, Sung-Hyeuk Park, Na-Rae Shin, Tae-Yang Jung, Hyun-A Kim, Sung-Hwan Kim, In-Sik Shin, Jong-Choon Kim
This study investigated the protective effects of diallyl disulfide (DADS) against acetaminophen (AAP)-induced acute renal injury in male rats. We also investigated the effects of DADS on kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL), which are novel biomarkers of nephrotoxicity in renal tissues, in response to AAP treatment. The following four experimental groups were evaluated: (1) vehicle control, (2) AAP (1,000 mg/kg), (3) AAP&DADS, and (4) DADS (50 mg/kg/day). AAP treatment caused acute kidney injury evidenced by increased serum blood urea nitrogen (BUN) levels and histopathological alterations...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28053612/ischemic-brain-injury-decreases-dynamin-like-protein-1-expression-in-a-middle-cerebral-artery-occlusion-animal-model-and-glutamate-exposed-ht22-cells
#10
Ah-Ram Jang, Phil-Ok Koh
Dynamin-like protein I (DLP-1) is an important mitochondrial fission and fusion protein that is associated with apoptotic cell death in neurodegenerative diseases. In this study, we investigated DLP-1 expression in a focal cerebral ischemia animal model and glutamate-exposed hippocampal-derived cell line. Middle cerebral artery occlusion (MCAO) was surgically induced in adult male rats to induce focal cerebral ischemic injury. Brain tissues were collected 24 hours after the onset of MCAO. MCAO induces an increase in infarct volume and histopathological changes in the cerebral cortex...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28053611/retrospective-growth-kinetics-and-radiosensitivity-analysis-of-various-human-xenograft-models
#11
Ji Young Lee, Mi-Sook Kim, Eun Ho Kim, Namhyun Chung, Youn Kyoung Jeong
The purpose of this study was to delineate the various factors that affect the growth characteristics of human cancer xenografts in nude mice and to reveal the relationship between the growth characteristics and radiosensitivity. We retrospectively analyzed 390 xenografts comprising nine different human cancer lines grown in nude mice used in our institute between 2009 and 2015. Tumor growth rate (TGR) was calculated using exponential growth equations. The relationship between the TGR of xenografts and the proliferation of the cells in vitro was examined...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28053610/evaluation-of-stability-and-biocompatibility-of-phema-pmma-keratoprosthesis-by-penetrating-keratoplasty-in-rabbits
#12
Yawon Hwang, Gonhyung Kim
Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMA-PMMA [poly (2-hydroxyl methacrylate)-poly (methyl methacrylate)] keratoprostheses in rabbits following penetrating keratoplasty. Sixteen male New Zealand White rabbits aged 16 weeks were divided into three groups. Group I and group II contained six rabbits each, while the control group had four rabbits. Experimental surgery was conducted under general anesthesia...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/27729934/anti-atherosclerotic-effects-of-perilla-oil-in-rabbits-fed-a-high-cholesterol-diet
#13
Yeseul Cha, Ja Young Jang, Young-Hwan Ban, Haiyu Guo, Kyungha Shin, Tae-Su Kim, Sung-Pyo Lee, Jieun Choi, Eun-Suk An, Da-Woom Seo, Jung-Min Yon, Ehn-Kyoung Choi, Yun-Bae Kim
Anti-atherosclerosis effects of perilla oil were investigated, in comparison with lovastatin, in rabbits fed a high-cholesterol diet (HCD). Hypercholesterolemia was induced in rabbits by feeding the HCD containing 0.5% cholesterol and 1% corn oil, and perilla oil (0.1 or 0.3%) was added to the diet containing 0.5% cholesterol for 10 weeks. HCD greatly increased blood total cholesterol and low-density lipoproteins, and caused thick atheromatous plaques, covering 74% of the aortic wall. Hyper-cholesterolemia also induced lipid accumulation in the liver and kidneys, leading to lipid peroxidation...
September 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/27729933/prevalence-of-salmonella-spp-in-pet-turtles-and-their-environment
#14
Du-San Back, Gee-Wook Shin, Mitchell Wendt, Gang-Joon Heo
Pet turtles are known as a source of Salmonella infection to humans when handled in captivity. Thirty four turtles purchased from pet shops and online markets in Korea were examined to determine whether the turtles and their environment were contaminated with Salmonella spp. Salmonella spp. were isolated from fecal samples of 17 turtles. These isolates were identified as S. enterica through 16S rRNA gene sequencing. The isolation rate of Salmonella spp. from the soil and water samples increased over time. We concluded that a high percentage of turtles being sold in pet shops were infected with Salmonella spp...
September 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/27729932/the-effects-of-dosage-and-the-routes-of-administrations-of-streptozotocin-and-alloxan-on-induction-rate-of-type1-diabetes-mellitus-and-mortality-rate-in-rats
#15
Ataroalsadat Mostafavinia, Abdodlah Amini, Seyed Kamran Ghorishi, Ramin Pouriran, Mohammad Bayat
The approach and novelty of this scientific work was to formulate the appropriate Streptozotocin (STZ) and Alloxan dosage in different routes of administration to imply minimum mortality rate and high incidence of diabetes mellitus (DM) in the rat experiment model. Rats were randomly divided into STZ, Alloxan and control groups. 1-Alloxan group was divided into two subgroups: intraperitoneal (ip) subgroups which received a single dose of, 140, 120, 100 and 80 mg/kg; and the subcutaneous (sc) subgroups which received a single dose of, 120, 110, 100, 90, and 80 mg/kg...
September 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/27729931/fermented-pueraria-lobata-extract-ameliorates-dextran-sulfate-sodium-induced-colitis-by-reducing-pro-inflammatory-cytokines-and-recovering-intestinal-barrier-function
#16
Seungho Choi, Jong-Kyu Woo, Yeong-Su Jang, Ju-Hee Kang, Jung-Eun Jang, Tae-Hoo Yi, Sang-Yong Park, Sun-Yeou Kim, Yeo-Sung Yoon, Seung Hyun Oh
Inflammatory bowel disease is a chronic inflammatory disorder occurring in the gastrointestinal track. However, the efficacy of current therapeutic strategies has been limited and accompanied by side effects. In order to eliminate the limitations, herbal medicines have recently been developed for treatment of IBD. Peuraria Lobata (Peuraria L.) is one of the traditional herbal medicines that have anti-inflammatory effects. Bioavailability of Peuraria L., which is rich in isoflavones, is lower than that of their fermented forms...
September 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/27729930/acute-toxicity-and-cytotoxicity-evaluation-of-dendrobium-moniliforme-aqueous-extract-in-vivo-and-in-vitro
#17
Mu-Jin Lee, Ho-Kyung Jung, Min-Suk Kim, Ji-Hun Jang, Mi-Ok Sim, Tea-Mook Kim, Ho Park, Byung-Kwan Ahn, Hyun-Woo Cho, Jung-Hee Cho, Won-Seok Jung, Jong-Choon Kim
Dendrobium moniliforme (L.) Sw., an herb of the Orchidaceae family, has long been used in traditional medicine to strengthen bones, nourish the stomach, and promote the production of bodily fluid. Recently, polysaccharides isolated from Dendrobium have been used in functional foods and nutraceutical products. A traditional method to process Dendrobium is to soak fresh stems in an ethanol solution, which is the most important factor to ensure high yields of aqueous-extractable polysaccharides. The present study was carried out to investigate the potential acute toxicity of D...
September 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/27729929/assessment-of-collagen-antibody-induced-arthritis-in-balb-c-mice-using-bioimaging-analysis-and-histopathological-examination
#18
Joo Hye Sim, Won Kil Lee, Yun Seok Lee, Jin Seok Kang
The aim of this study was to examine the therapeutic potential of sulfasalazine and prednisolone in a mouse collagen antibody-induced arthritis (CAIA) model. Twenty-five male BALB/c mice were randomly divided into five groups: group 1 (G1): control, group 2 (G2): probe control, group 3 (G3): CAIA, group 4 (G4): CAIA+sulfasalazine (10 mg/kg, oral), and group 5 (G5): CAIA+prednisolone (100 mg/kg, oral). Fluorescence bioimaging was performed in vivo 24 and 48 h after treatment with a fluorescence probe (OsteoSense® 680 EX), and all mice were sacrificed...
September 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/27382384/withdrawal-specific-nephrotoxicity-and-cardiotoxicity-of-bt-cal%C3%A2-sigma-anti-bonding-molecule-calcium-carbonate-in-mice
#19
Ja-Young Jang, Jingmei Cai, Jihyun Kim, Jangbeen Kyung, Dajeong Kim, Ehn-Kyoung Choi, Youngeun Kim, Kwang-Sei Kim, Dongsun Park, Hyun-Gu Kang, Yun-Bae Kim
[This retracts the article on p. 7 in vol. 29, PMID: 23573102.].
June 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/27382383/erratum-rapid-and-efficient-identification-of-the-mouse-leptin-receptor-mutation-c57blks-j-lepr-db-by-tetra-primer-amplification-refractory-mutation-system-polymerase-chain-reaction-arms-pcr-analysis
#20
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