journal
MENU ▼
Read by QxMD icon Read
search

Frontiers in Genetics

journal
https://www.readbyqxmd.com/read/29230237/rna-seq-of-plant-parasitic-nematode-meloidogyne-incognita-at-various-stages-of-its-development
#1
Inchan Choi, Parthiban Subramanian, Donghwan Shim, Byung-Ju Oh, Bum-Soo Hahn
No abstract text is available yet for this article.
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29230236/post-transcriptional-regulation-of-pcsk9-by-mir-191-mir-222-and-mir-224
#2
Parisa Naeli, Fatemeh Mirzadeh Azad, Mahshid Malakootian, Nabil G Seidah, Seyed J Mowla
Since proprotein convertase subtilisin kexin 9 (PCSK9) discovery, a gene involved in LDL metabolism regulation and cardiovascular diseases (CVD), many therapeutic strategies have been introduced for direct targeting of PCSK9. The main goal of these strategies has been to reduce PCSK9 protein level either by application of antibodies or inhibition of its production. In this study, we have tried to discover microRNAs (miRNAs) which can target, and hence regulate, PCSK9 expression. Using bioinformatics tools, we selected three microRNAs with binding sites on 3'-UTR of PCSK9...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29230235/editorial-ubiquitin-and-ubiquitin-relative-sumo-in-dna-damage-response
#3
EDITORIAL
Kristijan Ramadan, Ivan Dikic
No abstract text is available yet for this article.
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29230234/the-epigenetic-cytocrin-pathway-to-the-nucleus-epigenetic-factors-epigenetic-mediators-and-epigenetic-traits-a-biochemist-perspective
#4
Gemma Navarro, Nuria Franco, Eva Martínez-Pinilla, Rafael Franco
A single word, Epigenetics, underlies one exciting subject in today's Science, with different sides and with interactions with philosophy. The apparent trivial description includes everything in between genotype and phenotype that occurs for a given unique DNA sequence/genome. This Perspective article first presents an historical overview and the reasons for the lack of consensus in the field, which derives from different interpretations of the diverse operative definitions of Epigenetics. In an attempt to reconcile the different views, we propose a novel concept, the "cytocrin system...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29225612/hidden-diversity-in-the-populations-of-the-armored-catfish-ancistrus-kner-1854-loricariidae-hypostominae-from-the-paran%C3%A3-river-basin-revealed-by-molecular-and-cytogenetic-data
#5
Ana C Prizon, Daniel P Bruschi, Luciana A Borin-Carvalho, Andréa Cius, Ligia M Barbosa, Henrique B Ruiz, Claudio H Zawadzki, Alberto S Fenocchio, Ana L de Brito Portela-Castro
Only one species of armored catfish, Ancistrus cirrhosus Valenciennes 1836, has been historically described in the basin of the Paraná River, from Misiones (Argentina). However, the ample variation found in the morphology and coloration of the populations sampled in the tributaries of the Brazilian state of Paraná makes it difficult to establish the real taxonomic status and evolutionary history of the Ancistrus specimens, suggesting that A. cirrhosus is not the only species found in this basin. By combining data on mitochondrial DNA (COI gene) and chromosomal markers from different Ancistrus populations, totaling 144 specimens, in the tributaries of the Paraná, and specimens from Misiones (type-locality of A...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29218057/lessons-from-the-human-genome-project-modesty-honesty-and-realism
#6
Frank Emmert-Streib, Matthias Dehmer, Olli Yli-Harja
No abstract text is available yet for this article.
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29213278/translating-measures-of-biological-aging-to-test-effectiveness-of-geroprotective-interventions-what-can-we-learn-from-research-on-telomeres
#7
Waylon J Hastings, Idan Shalev, Daniel W Belsky
Intervention studies in animals suggest molecular changes underlying age-related disease and disability can be slowed or reversed. To speed translation of these so-called "geroprotective" therapies to prevent age-related disease and disability in humans, biomarkers are needed that can track changes in the rate of human aging over the course of intervention trials. Algorithm methods that measure biological processes of aging from combinations of DNA methylation marks or clinical biomarkers show promise. To identify next steps for establishing utility of these algorithm-based measures of biological aging for geroprotector trials, we considered the history a candidate biomarker of aging that has received substantial research attention, telomere length...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29209360/assortative-mating-by-ethnicity-in-longevous-families
#8
Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Stacy L Andersen, Thomas T Perls
Recent work shows strong evidence of ancestry-based assortative mating in spouse pairs of the older generation of the Framingham Heart Study. Here, we extend this analysis to two studies of human longevity: the Long Life Family Study (LLFS), and the New England Centenarian Study (NECS). In the LLFS, we identified 890 spouse pairs spanning two generations, while in the NECS we used data from 102 spouse pairs including offspring of centenarians. We used principal components of genome-wide genotype data to demonstrate strong evidence of ancestry-based assortative mating in spouse pairs of the older generation and also confirm the decreasing trend of endogamy in more recent generations...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29209359/wnt-%C3%AE-catenin-signaling-pathway-regulates-specific-lncrnas-that-impact-dermal-fibroblasts-and-skin-fibrosis
#9
Nathaniel K Mullin, Nikhil V Mallipeddi, Emily Hamburg-Shields, Beatriz Ibarra, Ahmad M Khalil, Radhika P Atit
Wnt/β-catenin signaling is required for embryonic dermal fibroblast cell fate, and dysregulation of this pathway is sufficient to promote fibrosis in adult tissue. The downstream modulators of Wnt/β-catenin signaling required for controlling cell fate and dermal fibrosis remain poorly understood. The discovery of regulatory long non-coding RNAs (lncRNAs) and their pivotal roles as key modulators of gene expression downstream of signaling cascades in various contexts prompted us to investigate their roles in Wnt/β-catenin signaling...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29209358/draft-of-zucchini-cucurbita-pepo-l-proteome-a-resource-for-genetic-and-genomic-studies
#10
Giuseppe Andolfo, Antimo Di Donato, Reza Darrudi, Angela Errico, Riccardo Aiese Cigliano, Maria R Ercolano
No abstract text is available yet for this article.
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29209357/hotair-a-promising-long-non-coding-rna-with-potential-role-in-breast-invasive-carcinoma
#11
Niloofar Avazpour, Mohammadreza Hajjari, Maryam Tahmasebi Birgani
No abstract text is available yet for this article.
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29204154/mitochondria-a-common-target-for-genetic-mutations-and-environmental-toxicants-in-parkinson-s-disease
#12
REVIEW
Martin P Helley, Jennifer Pinnell, Carolina Sportelli, Kim Tieu
Parkinson's disease (PD) is a devastating neurological movement disorder. Since its first discovery 200 years ago, genetic and environmental factors have been identified to play a role in PD development and progression. Although genetic studies have been the predominant driving force in PD research over the last few decades, currently only a small fraction of PD cases can be directly linked to monogenic mutations. The remaining cases have been attributed to other risk associated genes, environmental exposures and gene-environment interactions, making PD a multifactorial disorder with a complex etiology...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29187864/editorial-cancer-diagnostic-and-therapeutic-target-identification-and-verification-based-on-the-regulatory-functions-of-micrornas
#13
EDITORIAL
Lawrence W C Chan, S C C Wong
No abstract text is available yet for this article.
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29187863/smooth-an-hnrnp-l-homolog-might-decrease-mitochondrial-metabolism-by-post-transcriptional-regulation-of-isocitrate-dehydrogenase-idh-and-other-metabolic-genes-in-the-sub-acute-phase-of-traumatic-brain-injury
#14
Arko Sen, Katherine Gurdziel, Jenney Liu, Wen Qu, Oluwademi O Nuga, Rayanne B Burl, Maik Hüttemann, Roger Pique-Regi, Douglas M Ruden
Traumatic brain injury (TBI) can cause persistent pathological alteration of neurons. This may lead to cognitive dysfunction, depression and increased susceptibility to life threatening diseases, such as epilepsy and Alzheimer's disease. To investigate the underlying genetic and molecular basis of TBI, we subjected w1118Drosophila melanogaster to mild closed head trauma and found that mitochondrial activity is reduced in the brains of these flies 24 h after inflicting trauma. To determine the transcriptomic changes after mild TBI, we collected fly heads 24 h after inflicting trauma, and performed RNA-seq analyses...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29170679/frontiers-in-toxicogenomics-in-the-twenty-first-century-the-grand-challenge-to-understand-how-the-genome-and-epigenome-interact-with-the-toxic-environment-at-the-single-cell-whole-organism-and-multi-generational-level
#15
EDITORIAL
https://www.readbyqxmd.com/read/29163640/a-review-of-pathway-based-analysis-tools-that-visualize-genetic-variants
#16
REVIEW
Elisa Cirillo, Laurence D Parnell, Chris T Evelo
Pathway analysis is a powerful method for data analysis in genomics, most often applied to gene expression analysis. It is also promising for single-nucleotide polymorphism (SNP) data analysis, such as genome-wide association study data, because it allows the interpretation of variants with respect to the biological processes in which the affected genes and proteins are involved. Such analyses support an interactive evaluation of the possible effects of variations on function, regulation or interaction of gene products...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29163639/genetic-diversity-in-insect-metal-tolerance
#17
REVIEW
Thomas J S Merritt, Adam J Bewick
Insects encounter a variety of metals in their environment, many of which are required at some concentration for normal organismal homeostasis, but essentially all of which are toxic at higher concentrations. Insects have evolved a variety of genetic, and likely epigenetic, mechanisms to deal with metal stress. A recurring theme in all these systems is complexity and diversity; even simple, single gene, cases are complex. Of the known gene families, the metallothioneins are perhaps the best understood and provide good examples of how diverse metal response is...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29163638/network-analysis-reveals-putative-genes-affecting-meat-quality-in-angus-cattle
#18
Raluca G Mateescu, Dorian J Garrick, James M Reecy
Improvements in eating satisfaction will benefit consumers and should increase beef demand which is of interest to the beef industry. Tenderness, juiciness, and flavor are major determinants of the palatability of beef and are often used to reflect eating satisfaction. Carcass qualities are used as indicator traits for meat quality, with higher quality grade carcasses expected to relate to more tender and palatable meat. However, meat quality is a complex concept determined by many component traits making interpretation of genome-wide association studies (GWAS) on any one component challenging to interpret...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29163637/association-between-tgf-%C3%AE-1-polymorphisms-and-head-and-neck-cancer-risk-a-meta-analysis
#19
Quan Shi, Xing Wang, Chuan Cai, Shuo Yang, Na Huo, Hongchen Liu
Background and Objective: Studies have been conducted to explore the association between the single nucleotide polymorphisms (SNPs) in transforming growth factor beta 1 (TGF-β1) and head and neck cancer (HNC) susceptibility, however the findings are still inconclusive. Therefore, we conduct this meta-analysis to quantitatively assess the association. Methods: Embase and PubMed were searched for all eligible clinical studies. The odds ratio (OR) and 95% confidence interval (CI) of each study were pooled to estimate the association between SNPs in the TGF-β1 and the HNC risk...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29163636/a-pipeline-for-high-throughput-concentration-response-modeling-of-gene-expression-for-toxicogenomics
#20
John S House, Fabian A Grimm, Dereje D Jima, Yi-Hui Zhou, Ivan Rusyn, Fred A Wright
Cell-based assays are an attractive option to measure gene expression response to exposure, but the cost of whole-transcriptome RNA sequencing has been a barrier to the use of gene expression profiling for in vitro toxicity screening. In addition, standard RNA sequencing adds variability due to variable transcript length and amplification. Targeted probe-sequencing technologies such as TempO-Seq, with transcriptomic representation that can vary from hundreds of genes to the entire transcriptome, may reduce some components of variation...
2017: Frontiers in Genetics
journal
journal
43579
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"