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Clinical Obesity

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https://www.readbyqxmd.com/read/28815987/health-related-quality-of-life-in-randomized-controlled-trials-of-lorcaserin-for-obesity-management-what-mediates-improvement
#1
R L Kolotkin, R D Crosby, Z Wang
Lorcaserin, plus diet and exercise, has demonstrated significant weight loss and improved cardiometabolic parameters vs. placebo in patients with overweight/obesity in three randomized, placebo-controlled trials. We examined whether lorcaserin is also associated with greater improvements in health-related quality of life (HRQOL) and whether these improvements are wholly attributable to weight loss. Pooled data from Behavioral Modification and Lorcaserin for Overweight and Obesity Management (BLOOM), Behavioral Modification and Lorcaserin Second Study for Obesity Management (BLOSSOM) and BLOOM-Diabetes Mellitus (BLOOM-DM) trials were analysed (n = 5624)...
August 17, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28801963/a-preliminary-study-of-static-and-dynamic-balance-in-sedentary-obese-young-adults-the-relationship-between-bmi-posture-and-postural-balance
#2
J A do Nascimento, C C Silva, H H Dos Santos, J J de Almeida Ferreira, P R de Andrade
The aim of this study was to evaluate the postural control of obese young adults with normal body mass index during different static (bipedic and unipedic support) and dynamic postural conditions (gait velocity and limits of stability) in order to compare the static and dynamic balance of these individuals. A cross-sectional quantitative study was carried out to evaluate static and dynamic balance in 25 sedentary individuals. The sample was divided into two groups, 10 in the normal-weight group (24.70 ± 3...
August 11, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28801940/examining-the-association-between-depression-and-obesity-during-a-weight-management-programme
#3
N R Fuller, J Burns, A Sainsbury, S Horsfield, F da Luz, S Zhang, G Denyer, T P Markovic, I D Caterson
The prevalence of depression in those with obesity is reported to be as high as double that in individuals of normal weight. There is potentially a bi-directional relationship between obesity and depression. Some research has suggested that depression results in weight gain and obesity, and other studies have suggested that those with obesity are more likely to develop depression at a later stage. The aim of this study was to investigate the association of depression symptoms with weight change over a 12-month study...
August 11, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28744976/patient-experiences-of-adjusting-to-life-in-the-first-2%C3%A2-years-after-bariatric-surgery-a-qualitative-study
#4
Y Graham, C Hayes, P K Small, K Mahawar, J Ling
There is currently little research into the experiences of those who have undergone bariatric surgery, or how surgery affects their lives and social interactions. Adopting a constructivist grounded theory methodological approach with a constant comparative analytical framework, semi-structured interviews were carried out with 18 participants (11 female, 7 male) who had undergone permanent bariatric surgical procedures 5-24 months prior to interview. Findings revealed that participants regarded social encounters after bariatric surgery as underpinned by risk...
July 26, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28707388/the-associations-of-large-for-gestational-age-and-infant-feeding-practices-with-children-s-body-mass-index-z-score-trajectories-the-early-childhood-longitudinal-study-birth-cohort
#5
M Salahuddin, A Pérez, N Ranjit, D M Hoelscher, S H Kelder
Very few studies have examined if high birth weight and infant feeding practices have implications for the trajectory of body mass index (BMI) growth across the early childhood period. The goal of this study was to assess if large-for-gestational-age (LGA) and infant feeding practices (exclusive breastfeeding for 6 months, and early introduction of complementary food prior to 4 months) are associated with BMI z-score trajectories over the early childhood period. Group-based trajectory modelling (GBTM) methods were employed to describe and classify developmental BMI z-score trajectories (the outcome of interest) in children from 9 months to 4 years of age (n = 4497) born to prenatal non-smoking mothers in the Early Childhood Longitudinal Study, Birth Cohort (2001-2005)...
July 14, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28695722/a-systematic-review-of-reviews-exploring-the-relationship-between-obesity-weight-loss-and-health-related-quality-of-life
#6
REVIEW
R L Kolotkin, J R Andersen
This is the first systematic review of reviews to assess the effect of obesity and weight loss on health-related quality of life (HRQoL). We identified 12 meta-analyses/systematic reviews published between January 2001 and July 2016. They addressed the following themes: (i) the relationship between weight/body mass index and HRQoL (baseline/pre-intervention; n = 2). (ii) HRQoL after weight loss (varied interventions and/or study design; n = 2). (iii) HRQoL after weight loss (randomized controlled trials only; n = 2)...
July 10, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28695579/exploring-the-evidence-base-for-tier-3-weight-management-interventions-for-adults-a-systematic-review
#7
REVIEW
T J Brown, C O'Malley, J Blackshaw, V Coulton, A Tedstone, C Summerbell, L J Ells
Specialist weight management services provide a treatment option for severe obesity. The objective of the study is to review the characteristics, impact and practice implications of specialist weight management services for adults in the UK. Systematic review: EMBASE, MEDLINE and PsycINFO were searched from January 2005 to March 2016 with supplementary searches. Adults with a body mass index of ≥40 kg m(-2) , or ≥35 kg m(-2) with comorbidity or ≥30 kg m(-2) with type 2 diabetes and any study of multicomponent interventions, in any UK or Ireland setting, delivered by a specialist multidisciplinary team are the inclusion criteria...
July 10, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28557382/parental-pre-pregnancy-obesity-and-the-risk-of-offspring-weight-and-body-mass-index-change-from-childhood-to-adulthood
#8
N Zalbahar, J Najman, H D McIntyre, A Mamun
The purpose of this study was to examine the association of parental pre-pregnancy weight and body mass index (BMI) on offspring weight and BMI change from childhood to adulthood. We analysed BMI data from a subsample of parents (n = 1494) from the Mater-University of Queensland Study of Pregnancy cohort that started in the early 1980s in Brisbane, Australia: data were collected at pre-pregnancy and then also for offspring at 5, 14 and 21-year follow-ups. Multiple regression for continuous outcomes and multinomial regression for categorical outcomes were performed...
May 30, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28557355/screening-methods-for-obstructive-sleep-apnoea-in-severely-obese-pregnant-women
#9
H Longworth, K McCallin, R P Narayanan, M A Turner, S Quenby, D Rycroft, M Charnley, J Abayomi, J Topping, A D Weeks, J P H Wilding
Obstructive sleep apnoea (OSA) is an often-overlooked diagnosis, more prevalent in the obese population. Screening method accuracy, uptake and hence diagnosis is variable. There is limited data available regarding the obese pregnant population; however, many studies highlight potential risks of apnoeic episodes to mother and foetus, including hypertension, diabetes and preeclampsia. A total of 162 women with a body mass index (BMI) ≥ 35 were recruited from a tertiary referral hospital in the northwest of England...
May 29, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28557240/selective-outcome-reporting-in-obesity-clinical-trials-a-cross-sectional-review
#10
J Rankin, A Ross, J Baker, M O'Brien, C Scheckel, M Vassar
Selective outcome reporting is a form of bias resulting from discrepancies between outcomes presented in a trial's registration and the published report. We investigate this selective bias in obesity clinical trials. A PubMed search was conducted to identify randomized controlled trials (RCTs) published in four obesity journals from 2013 to 2015. Primary, secondary and tertiary outcomes were recorded for each trial and compared to pre-specified outcomes in each trial's registration. Of the 392 identified articles, 142 were included in the final analysis; 22 (15%) RCTs demonstrated major outcome discrepancies between registration and publication: No primary outcomes were demoted to a secondary or tertiary outcome; 14 (36...
August 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28508579/childhood-obesity-treatment-telephone-coaching-is-as-good-as-usual-care-in-maintaining-weight-loss-a-randomized-controlled-trial
#11
A Bohlin, E Hagman, S Klaesson, P Danielsson
There is a need for more flexible treatment strategies to help patients reach relevant treatment outcomes and adhere better to treatment. The aim of this study was to evaluate the long-term efficacy, in terms of patients' weight status, of replacing usual care (UC) physical visits with more frequent but shorter telephone coaching (TC) sessions as part of a structured childhood obesity treatment. In this controlled study, patients aged 5-14 years from the Södertälje outpatient clinic, Sweden were randomized to either UC or TC over an 18-month period after participating in an initial standard obesity treatment programme...
August 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28320073/a-model-linking-video-gaming-sleep-quality-sweet-drinks-consumption-and-obesity-among-children-and-youth
#12
O Turel, A Romashkin, K M Morrison
There is a growing need to curb paediatric obesity. The aim of this study is to untangle associations between video-game-use attributes and obesity as a first step towards identifying and examining possible interventions. Cross-sectional time-lagged cohort study was employed using parent-child surveys (t1) and objective physical activity and physiological measures (t2) from 125 children/adolescents (mean age = 13.06, 9-17-year-olds) who play video games, recruited from two clinics at a Canadian academic children's hospital...
August 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28340516/markers-of-dietary-protein-intake-are-associated-with-successful-weight-loss-in-the-pounds-lost-trial
#13
G A Bray, D H Ryan, W Johnson, C M Champagne, C M Johnson, J Rood, D A Williamson, F M Sacks
To assess the association of markers for dietary protein intake, measures of dietary adherence and demographic variables with weight loss in the POUNDS Lost study over the first 6 months and again between 6 and 24 months using data from those who completed each period. This is a secondary analysis of pooled data on completers assigned to one of four diets: 65%C/15%P/20%F (AP/LF), 55%C/25%P/20%F (HP/LF), 45%C/15%P/40%F (AP/HF) or 35%C/25%P40%F (HP/HF) in the POUNDS Lost study. Urinary nitrogen excretion, dietary adherence measured by 24-h recall and attendance at sessions, age (above and below 50 years), gender, race/ethnicity and activity by pedometry were analysed...
June 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28320077/marginal-ulcers-after-one-anastomosis-mini-gastric-bypass-a-survey-of-surgeons
#14
K K Mahawar, A N Reed, Y N H Graham
Many surgeons believe that one anastomosis (mini) gastric bypass (OAGB/MGB) is associated with a high marginal ulcer (MU) rate and that this is associated with complications in a significant number of patients. The purpose of this survey was to find out the participant-reported incidence of MU after OAGB/MGB and its complications. We also aimed to understand practices in this cohort concerning prophylaxis, diagnosis, treatment and management of complications. Bariatric surgeons who perform OAGB/MGB procedures were invited to participate in a confidential, online survey using SurveyMonkey®...
June 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28296261/determinants-of-adherence-to-lifestyle-intervention-in-adults-with-obesity-a-systematic-review
#15
REVIEW
E Burgess, P Hassmén, K L Pumpa
Lifestyle intervention programmes are efficacious in the management of obesity but often report poor attendance and adherence rates that hinder treatment effectiveness and health outcomes. The aim of this systematic review is to identify (i) barriers to behaviour change and (ii) predictors of adherence to lifestyle intervention programmes in adults with obesity. Studies were identified by systematically reviewing the literature within Medline, PsycINFO, CINAHL, SPORTDiscus and Web of Science from inception to August 2016...
June 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28294570/how-does-obesity-affect-the-endocrine-system-a-narrative-review
#16
REVIEW
M Poddar, Y Chetty, V T Chetty
Obesity is a chronic, relapsing medical condition that results from an imbalance of energy expenditure and consumption. It is a leading cause of preventable illness, disability and premature death. The causes of obesity are multifactorial and include behavioural, socioeconomic, genetic, environmental and psychosocial factors. Rarely are endocrine diseases, e.g., hypothyroidism or Cushing's syndrome, the cause of obesity. What is less understood is how obesity affects the endocrine system. In this review, we will discuss the impact of obesity on multiple endocrine systems, including the hypothalamic-pituitary axis, changes in vitamin D homeostasis, gender steroids and thyroid hormones...
June 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28544443/development-of-a-clinical-trials-version-of-the-impact-of-weight-on-quality-of-life-lite-questionnaire-iwqol-lite-clinical-trials-version-results-from-two-qualitative-studies
#17
R L Kolotkin, C M Ervin, H H Meincke, L Højbjerre, S E Fehnel
Existing measures of health-related quality of life and patient functioning in obesity, such as the Impact of Weight on Quality of Life-Lite (IWQOL-Lite) questionnaire, lack the developmental rigour required by the Food and Drug Administration (FDA) to support product labelling. Two iterative qualitative studies informed development of a version of the IWQOL-Lite questionnaire optimized for use in obesity clinical trials: the IWQOL-Lite Clinical Trials Version. Study 1 included 42 patients with body mass index (BMI) ≥ 30 kg m(-2) (obesity); and Study 2 included 29 patients with type 2 diabetes and BMI ≥ 27 kg m(-2) (overweight)...
May 22, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28429583/a-qualitative-study-of-the-role-of-australian-general-practitioners-in-the-surgical-management-of-obesity
#18
K Jose, A Venn, M Nelson, F Howes, S Wilkinson, D Ezzy
General practitioners (GPs) are increasingly managing patients with class 2 and 3 obesity (body mass index [BMI] > 35 and 40 kg/m(2) , respectively). Bariatric surgery is considered for patients with class 2 obesity and comorbidities or class 3 obesity where sustained weight loss using non-surgical interventions has not been achieved. In Australia, GPs facilitate access to surgery through referral processes, but the nature of GP involvement in bariatric pre- and post-surgery care is currently unclear...
April 20, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28429577/investigating-general-medication-prescription-by-general-practitioners-during-a-12-month-randomized-controlled-weight-loss-trial
#19
N R Fuller, N S Lau, T P Markovic, I D Caterson
Much healthcare expenditure is on pharmaceutical drugs. Expenditure on medications has increased both in absolute terms, and as a proportion of total health expenditure. No previous studies have investigated the prescribing costs by general practitioners when managing patients during a weight loss intervention. This study evaluated the medication costs by individual class during a 1-year study in which 268 participants were randomized to one of two weight loss programmes, either standard care (SC) as defined by national guidelines, or a commercial provider (Weight Watchers) (CP)...
April 20, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28397375/elevation-of-circulating-microrna-levels-in-obese-children-compared-to-healthy-controls
#20
M D Thompson, M J Cismowski, M Serpico, A Pusateri, D R Brigstock
As childhood obesity increases, it is becoming important to understand the complications of obesity in children and develop novel biomarkers. Evidence indicates that microRNAs (miRNA) are dys-regulated in obesity and may serve as sensitive and specific circulating biomarkers. Non-alcoholic fatty liver disease (NAFLD) is a complication of obesity that ultimately requires a liver biopsy to determine disease severity. While studies have been conducted in adults, no study to date has examined circulating miRNAs in children with obesity and NAFLD...
April 10, 2017: Clinical Obesity
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