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ClinicoEconomics and Outcomes Research: CEOR

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https://www.readbyqxmd.com/read/29983583/post-lumbar-discectomy-reoperations-that-are-associated-with-poor-clinical-and-socioeconomic-outcomes-can-be-reduced-through-use-of-a-novel-annular-closure-device-results-from-a-2-year-randomized-controlled-trial
#1
Peter Douglas Klassen, Wellington K Hsu, Frederic Martens, Jason A Inzana, Wimar A van den Brink, Michael W Groff, Claudius Thomé
Introduction: Lumbar discectomy patients with large annular defects are at a high risk for reherniation and reoperation, which could be mitigated through the use of an annular closure device (ACD). To identify the most effective treatment pathways for this high-risk population, it is critical to understand the clinical outcomes and socioeconomic costs among reoperated patients as well as the utility of ACD for minimizing reoperation risk. Methods: This was a post hoc analysis of a prospective, multicenter, randomized controlled trial (RCT) designed to investigate the safety and efficacy of an ACD...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29983582/evaluation-of-statin-utilization-in-the-republic-of-macedonia-during-2013-2016
#2
Zorica Naumovska, Aleksandra K Nestorovska, Aleksandra Grozdanova, Kristina Hristova, Aleksandar Dimovski, Ljubica Suturkova, Zoran Sterjev
Purpose: A rational use of statins has a major and increasing importance in public health and allocation of financial resources by the health insurance funds (HIFs). The aim of this study was to evaluate the market share and utilization trends of statins in the Republic of Macedonia (R. Macedonia) from 2013 to 2016. Materials and methods: A retrospective analysis and data comparison for the utilization of HMG-CoA inhibitors (C10AA) in R. Macedonia from 2013 to 2016 were conducted...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29950875/cost-effectiveness-analysis-of-treating-transplant-eligible-multiple-myeloma-patients-in-macedonia
#3
Vjollca Qerimi, Aleksandra Kapedanovska Nestorovska, Zoran Sterjev, Sonja Genadieva-Stavric, Ljubica Suturkova
Purpose: A decision-analytic model was developed to study the impact of induction regimens vincristine, adriamycin, dexamethasone (VAD); thalidomide, dexamethasone (TD); and bortezomib, dexamethasone (BorD), followed by autologous stem cell transplantation (ASCT) for treating multiple myeloma (MM) patients in Macedonia. Additionally, a cost-effectiveness analysis (CEA) of treatment sequences to predict health effects and costs of different treatment sequences was performed. Methods: Model strategies were based on a previously published study for treating patients with MM in Macedonia...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29922079/the-cost-of-dysphagia-in-geriatric-patients
#4
Signe Westmark, Dorte Melgaard, Line O Rethmeier, Lars Holger Ehlers
Objectives: To estimate the annual cost at the hospital and in the municipality (social care) due to dysphagia in geriatric patients. Design: Retrospective cost analysis of geriatric patients with dysphagia versus geriatric patients without dysphagia 1 year before hospitalization. Setting: North Denmark Regional Hospital, Hjørring Municipality, Frederikshavn Municipality, and Brønderslev Municipality. Subjects: A total of 258 hospitalized patients, 60 years or older, acute hospitalized in the geriatric department...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29922078/a-systematic-literature-review-of-the-clinical-and-health-economic-burden-of-schizophrenia-in-privately-insured-patients-in-the-united-states
#5
REVIEW
Wenjie Zhang, Tony B Amos, Stephen W Gutkin, Nicole Lodowski, Emma Giegerich, Kruti Joshi
Purpose: The aim of this study was to conduct a systematic literature review on the burden of schizophrenia in privately insured US patients. Materials and methods: A systematic literature review of English language peer-reviewed journal articles of observational studies published from 2006 to 2016 was conducted using EMBASE/MEDLINE databases. Abstracts covering substantial numbers of patients with schizophrenia or schizoaffective disorder (i.e., N ≥ 100) were included for full-text review...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29892201/a-comparison-between-whodas-2-0-and-modified-barthel-index-which-tool-is-more-suitable-for-assessing-the-disability-and-the-recovery-rate-in-orthopedic-rehabilitation
#6
Tiziana Galli, Paolo Mirata, Emanuela Foglia, Davide Croce, Emanuele Porazzi, Lucrezia Ferrario, Elena Ricci, Elisabetta Garagiola, Roberta Pagani, Giuseppe Banfi
Purpose: The aim of the present study was to compare 2 clinical assessment tools, the Modified Barthel Index (currently administered to patients admitted into inpatient rehabilitation units after elective hip or knee arthroplasty) with the World Health Organization Disability Assessment Schedule (WHODAS) 2.0 scale, in order to identify which tool is more suitable for assessing the disability and the "recovery rate". Patients and methods: A perspective multicenter observational study was developed, involving 2 hospital authorities in Italy...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29892200/early-introduction-of-a-semi-elemental-formula-may-be-cost-saving-compared-to-a-polymeric-formula-among-critically-ill-patients-requiring-enteral-nutrition-a-cohort-cost-consequence-model
#7
Alistair S Curry, Shkun Chadda, Aurélie Danel, Douglas L Nguyen
Objectives: Gastrointestinal (GI) intolerance is associated with adverse outcomes in critically ill patients receiving enteral nutrition (EN). The objective of this analysis is to quantify the cost of GI intolerance and the cost implications of starting with semi-elemental EN in intensive care units (ICUs). Study design: A US-based cost-consequence model was developed to compare the costs for patients with and without GI intolerance and the costs with semi-elemental or standard EN while varying the proportion of GI intolerance cases avoided...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29881300/cost-effectiveness-of-pulse-echo-ultrasonometry-in-osteoporosis-management
#8
Erkki Soini, Ossi Riekkinen, Heikki Kröger, Petri Mankinen, Taru Hallinen, Janne P Karjalainen
Purpose: Osteoporosis is asymptomatic morbidity of the elderly which develops slowly over several years. Osteoporosis diagnosis has typically involved Fracture Risk Assessment (FRAX) followed by dual energy X-ray absorptiometry (DXA) in specialist care. Point-of-care pulse-echo ultrasound (PEUS) was developed to overcome DXA-related access issues and to enable faster fracture prevention treatment (FPT) initiation. The objective of this study was to evaluate the cost-effectiveness of two proposed osteoporosis management (POMs: FRAX→PEUS-if-needed→DXA-if-needed→FPT-if-needed) pathways including PEUS compared with the current osteoporosis management (FRAX→DXA-if-needed→FPT-if-needed)...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29881299/economic-evaluation-of-point-of-care-testing-in-the-remote-primary-health-care-setting-of-australia-s-northern-territory
#9
Brooke A Spaeth, Billingsley Kaambwa, Mark Ds Shephard, Rodney Omond
Aim: To determine the cost-effectiveness of utilizing point-of-care testing (POCT) on the Abbott i-STAT device as a support tool to aid decisions regarding the emergency medical retrievals of patients at remote health centers in the Northern Territory (NT) of Australia. Methods: A decision analytic simulation model-based economic evaluation was conducted using data from patients presenting with three common acute conditions (chest pain, chronic renal failure due to missed dialysis session(s), and acute diarrhea) at six remote NT health centers from July to December 2015...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29765242/claims-based-proxies-of-patient-instability-among-commercially-insured-adults-with-schizophrenia
#10
Charles Ruetsch, Hyong Un, Heidi C Waters
Objective: Schizophrenia (Sz) patients are among the highest utilizers of hospital-based services. Prevention of relapse is in part a treatment goal in order to reduce hospital admissions. However, predicting relapse is a challenge, particularly for payers and disease management firms with only access to claims data. Understandably, such organizations have had little success predicting relapse. A tool that allows payers to identify patients at elevated risk of relapse could facilitate targeted interventions prior to relapse and avoid rehospitalization...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29765241/prevalence-of-antibiotic-prescription-in-southern-italian-outpatients-real-world-data-analysis-of-socioeconomic-and-sociodemographic-variables-at-a-municipality-level
#11
Veronica Russo, Valeria Marina Monetti, Francesca Guerriero, Ugo Trama, Antonella Guida, Enrica Menditto, Valentina Orlando
Purpose: The aim of this study was to analyze the geographic variation in systemic antibiotic prescription at a regional level and to explore the influence of socioeconomic and sociodemographic variables. Methods: This study was a retrospective analysis of reimbursement pharmacy records in the outpatient settings of Italy's Campania Region in 2016. Standardized antibiotic prescription rates were calculated at municipality and Local Health Unit (LHU) level. Antibiotic consumption was analyzed as defined daily doses (DDD)/1000 inhabitants per day (DID)...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29719414/cost-effectiveness-comparison-of-cabozantinib-with-everolimus-axitinib-and-nivolumab-in-the-treatment-of-advanced-renal-cell-carcinoma-following-the-failure-of-prior-therapy-in-england
#12
Jie Meng, Johanna Lister, Anne-Lise Vataire, Roman Casciano, Jerome Dinet
Purpose: The aim of this study was to compare the cost-effectiveness of cabozantinib with the standard of care in England in adult patients with advanced renal cell carcinoma (aRCC), following prior vascular endothelial growth factor receptor (VEGFR)-targeted therapy. Methods: We developed a partitioned-survival model with three health states to assess the cost-effectiveness of cabozantinib and its comparators. The model time horizon was 30 years. Efficacy and safety data were derived from pivotal clinical trials (METEOR: NCT01865747, CheckMate025: NCT01668784, and AXIS: NCT00678392)...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29719413/intermittent-pneumatic-compression-is-a-cost-effective-method-of-orthopedic-postsurgical-venous-thromboembolism-prophylaxis
#13
Rhodri Saunders, Anthony J Comerota, Audrey Ozols, Rafael Torrejon Torres, Kwok Ming Ho
Background: Venous thromboembolism (VTE) is a major complication after lower-limb arthroplasty that increases costs and reduces patient's quality of life. Using anticoagulants for 10-35 days following arthroplasty is the standard prophylaxis, but its cost-effectiveness after accounting for bleeding complications remains unproven. Methods: A comprehensive, clinical model of VTE was created using the incidences, clinical effects (including bleeding), and costs of VTE and prophylaxis from randomized controlled trials, meta-analyses, and large observational studies...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29692618/an-evaluation-of-the-budget-impact-of-a-new-20-subcutaneous-immunoglobulin-ig20gly-for-the-management-of-primary-immunodeficiency-diseases-in-switzerland
#14
Richard F Pollock, Lisa M Meckley
Introduction: While most individual primary immunodeficiency diseases (PID) are rare, the collective prevalence of PID results in a substantial economic and clinical burden. The aim of this study was to evaluate the budgetary implications of Ig20Gly (Immune Globulin Subcutaneous [human] 20% solution; CUVITRU ® , Baxalta US Inc, now part of Shire Plc, Westlake Village, CA, USA) as a treatment for PID relative to intravenous immunoglobulin (IVIG) and other subcutaneous immunoglobulin (SCIG) formulations in the Swiss health care setting...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29670383/the-economic-and-clinical-burden-of-early-versus-late-initiation-of-celecoxib-among-patients-with-osteoarthritis
#15
Ahmed Shelbaya, Caitlyn T Solem, Chris Walker, Yin Wan, Courtney Johnson, Joseph C Cappelleri
Objective: This study aimed to evaluate the characteristics associated with early versus late initiation of celecoxib treatment after osteoarthritis (OA) diagnosis and whether economic and safety outcomes differ between patients with early versus late initiation of celecoxib. Methods: Adults (≥18 years) with a confirmed OA diagnosis (International Classification of Diseases, 9th Edition, Clinical Modifications code: 715.XX), ≥12 months of continuous pre- and post-index enrollment, and ≥1 post-index claim for celecoxib were included from the MarketScan® Commercial Claims and Encounter Database (2009-2013)...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29670382/clinical-outcomes-and-health-care-utilization-pre-and-post-laparoscopic-radiofrequency-ablation-of-symptomatic-fibroids-and-laparoscopic-myomectomy-a-randomized-trial-of-uterine-sparing-techniques-trust-in-canada
#16
Darrien D Rattray, Laura Weins, Lexy C Regush, James M Bowen, Daria O'Reilly, John A Thiel
Objective: The objective of this study was to compare laparoscopic ultrasound-guided radiofrequency ablation of fibroids (Lap-RFA) and laparoscopic myomectomy in terms of 1) health care utilization and 2) serious complication rates. The secondary objectives were comparison of subject responses to validated symptom and quality-of-life questionnaires. We hypothesized that Lap-RFA health care utilization and clinical outcomes would not be worse than those of laparoscopic myomectomy in the aggregate...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29618934/analysis-of-utilization-patterns-and-associated-costs-of-the-breast-imaging-and-diagnostic-procedures-after-screening-mammography
#17
Anna Vlahiotis, Brian Griffin, A Thomas Stavros, Jay Margolis
Background: Little data exist on real-world patterns and associated costs of downstream breast diagnostic procedures following an abnormal screening mammography or clinical exam. Objectives: To analyze the utilization patterns in real-world clinical settings for breast imaging and diagnostic procedures, including the frequency and volume of patients and procedures, procedure sequencing, and associated health care expenditures. Materials and methods: Using medical claims from 2011 to 2015 MarketScan Commercial and Medicare Databases, adult females with breast imaging/diagnostic procedures (diagnostic mammography, ultrasound, molecular breast imaging, tomosynthesis, magnetic resonance imaging, or biopsy) other than screening mammography were selected...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29593426/clinical-and-economic-impact-of-the-21-gene-recurrence-score-assay-in-adjuvant-therapy-decision-making-in-patients-with-early-stage-breast-cancer-pooled-analysis-in-4-basque-country-university-hospitals
#18
Purificación Martínez Del Prado, Isabel Alvarez-López, Severina Domínguez-Fernández, Arrate Plazaola, Oliver Ibarrondo, Elena Galve-Calvo, Nerea Ancizar-Lizarraga, María Gutierrez-Toribio, Ainhara Lahuerta-Martínez, Javier Mar
Purpose: The 21-gene recurrence score (RS) is a genomic test developed as a prognostic and predictive tool to improve the treatment decision making in cases of estrogen receptor-positive and human epidermal growth factor receptor 2-negative early-stage breast cancer. This study examined the clinical and economic impact of its use in 4 Basque Country university hospitals. Methods: Taking into consideration the RS result, we recorded the recommended initial systemic adjuvant therapy (endocrine therapy with or without chemotherapy) according to standard clinicopathologic factors and the final decision about chemotherapy...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29588607/cost-analysis-of-a-growth-guidance-system-compared-with-traditional-and-magnetically-controlled-growing-rods-for-early-onset-scoliosis-a-us-based-integrated-health-care-delivery-system-perspective
#19
Scott J Luhmann, Eoin M McAughey, Stacey J Ackerman, David B Bumpass, Richard E McCarthy
Purpose: Treating early-onset scoliosis (EOS) with traditional growing rods (TGR) is effective but requires periodic surgical lengthening, risking complications. Alternatives include magnetically controlled growing rods (MCGR) that lengthen noninvasively and the growth guidance system (GGS), which obviate the need for active, distractive lengthenings. Previous studies have reported promising clinical effectiveness for GGS; however the direct medical costs of GGS compared to TGR and MCGR have not yet been explored...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29588606/cost-utility-budget-impact-and-scenario-analysis-of-racecadotril-in-addition-to-oral-rehydration-for-acute-diarrhea-in-children-in-malaysia
#20
Tamlyn Anne Rautenberg, Ute Zerwes, Way Seah Lee
Objective: To perform cost utility (CU) and budget impact (BI) analyses augmented by scenario analyses of critical model structure components to evaluate racecadotril as adjuvant to oral rehydration solution (ORS) for children under 5 years with acute diarrhea in Malaysia. Methods: A CU model was adapted to evaluate racecadotril plus ORS vs ORS alone for acute diarrhea in children younger than 5 years from a Malaysian public payer's perspective. A bespoke BI analysis was undertaken in addition to detailed scenario analyses with respect to critical model structure components...
2018: ClinicoEconomics and Outcomes Research: CEOR
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