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Journal of Gastric Cancer

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https://www.readbyqxmd.com/read/29302378/potential-utility-of-fdg-pet-ct-as-a-non-invasive-tool-for-monitoring-local-immune-responses
#1
Seungho Lee, Seohee Choi, Sang Yong Kim, Mi Jin Yun, Hyoung-Il Kim
Purpose: The tumor microenvironment is known to be associated with the metabolic activity of cancer cells and local immune reactions. We hypothesized that glucose metabolism measured by 2-deoxy-2-(18F)fluoro-D-glucose (18F-FDG) positron emission tomography (PET)-computed tomography (CT) (18F-FDG PET-CT) would be associated with local immune responses evaluated according to the presence of tumor infiltrating lymphocytes (TILs). Materials and Methods: We retrospectively reviewed 56 patients who underwent 18F-FDG PET-CT prior to gastrectomy...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29302377/clinical-outcomes-of-endoscopic-hemostasis-for-bleeding-in-patients-with-unresectable-advanced-gastric-cancer
#2
In Ji Song, Hyun Ju Kim, Ji Ae Lee, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Hyunsoo Chung
Purpose: Bleeding is one of the most serious complications of advanced gastric cancer (AGC) and is associated with a poor prognosis. This study aimed to evaluate the clinical outcomes of endoscopic hemostasis for bleeding in patients with unresectable AGC. Materials and Methods: This study included 106 patients with bleeding associated with gastric cancer who had undergone endoscopic hemostasis between January 2010 and December 2013. Clinical characteristics, treatment outcomes, including rates of successful endoscopic hemostasis and rebleeding, risk factors for rebleeding, and overall survival (OS) were investigated...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29302376/clinicopathological-significance-of-large-tumor-suppressor-lats-expression-in-gastric-cancer
#3
Myoung Won Son, Geum Jong Song, Si-Hyong Jang, Soon Auck Hong, Mee-Hye Oh, Ji-Hye Lee, Moo Jun Baek, Moon Soo Lee
Purpose: The aims of this study were to evaluate the expression of the large tumor suppressor (LATS) genes LATS1 and LATS2 by immunohistochemical staining of gastric cancer, and to evaluate the clinicopathological significance of LATS expression and its correlation with overall survival (OS). Materials and Methods: LATS1 and LATS2 expression in a tissue microarray was detected by immunohistochemistry, using 264 gastric cancer specimens surgically resected between July 2006 and December 2009...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29302375/laparoscopic-reinforcement-suture-lars-on-staple-line-of-duodenal-stump-using-barbed-suture-in-laparoscopic-gastrectomy-for-gastric-cancer-a-prospective-single-arm-phase-ii-study
#4
Min Chan Kim, Sang Yun Kim, Kwan Woo Kim
Purpose: Laparoscopic gastrectomy is accepted as a standard treatment for patients with early gastric cancer in Korea, Japan, and China. However, duodenal stump leakage remains a fatal complication after gastrectomy. We conducted a prospective phase II study to evaluate the safety of the new technique of laparoscopic reinforcement suture (LARS) on the duodenal stump. Materials and Methods: The estimated number of patients required for this study was 100 for a period of 18 months...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29302374/using-quality-of-life-scales-with-nutritional-relevance-after-gastrectomy-a-challenge-for-providing-personalized-treatment
#5
Seung Soo Lee, Wansik Yu, Ho Young Chung, Oh Kyoung Kwon, Won Kee Lee
Purpose: This study evaluated the changes in nutritional status based on quality of life (QoL) item-level analysis to determine whether individual QoL responses might facilitate personal clinical impact. Materials and Methods: This study retrospectively evaluated QoL data obtained by the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 (QLQ-C30) and Quality of Life Questionnaire-Stomach (QLQ-STO22) as well as metabolic-nutritional data obtained by bioelectrical impedance analysis and blood tests...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29302373/risk-factors-of-microscopic-invasion-in-early-gastric-cancer
#6
Jong-Ho Choi, Yun-Suhk Suh, Shin-Hoo Park, Seong-Ho Kong, Hyuk-Joon Lee, Woo Ho Kim, Han-Kwang Yang
Purpose: This study aimed to evaluate the clinical significance of microscopic invasion to determine the adequate resection margin in early gastric cancer (EGC). Materials and Methods: A retrospective review was performed that included patients who underwent gastrectomy for clinical early gastric cancer (cEGC) at Seoul National University Hospital between January 2007 and December 2010. After subtracting the microscopic resection margin from the gross resection margin for each proximal or distal resection margin, microscopic invasion was represented by the larger value...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29302372/extensive-lymph-node-dissection-improves-survival-among-american-patients-with-gastric-adenocarcinoma-treated-surgically-analysis-of-the-national-cancer-database
#7
Samer A Naffouje, George I Salti
Introduction: The extent of lymphadenectomy in the surgical treatment of gastric cancer is a topic of controversy among surgeons. This study was conducted to analyze the American National Cancer Database (NCDB) and conclude the optimal extent of lymphadenectomy for gastric adenocarcinoma. Methods: The NCDB for gastric cancer was utilized. Patients who received at least a partial gastrectomy were included. Patients with metastatic disease, unknown TNM stages, R1/R2 resection, or treated with a palliative intent were excluded...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29302371/greater-lymph-node-retrieval-improves-survival-in-node-negative-resected-gastric-cancer-in-the-united-states
#8
Katelin A Mirkin, Christopher S Hollenbeak, Joyce Wong
Purpose: Guidelines in western countries recommend retrieving ≥15 lymph nodes (LNs) during gastric cancer resection. This study sought to determine whether the number of examined lymph nodes (eLNs), a proxy for lymphadenectomy, effects survival in node-negative disease. Materials and Methods: The US National Cancer Database (2003-2011) was reviewed for node-negative gastric adenocarcinoma. Treatment was categorized by neoadjuvant therapy (NAT) vs. initial resection, and further stratified by eLN...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29302370/atm-signaling-pathway-is-implicated-in-the-smyd3-mediated-proliferation-and-migration-of-gastric-cancer-cells
#9
Lei Wang, Qiu-Tong Wang, Yu-Peng Liu, Qing-Qing Dong, Hai-Jie Hu, Zhi Miao, Shuang Li, Yong Liu, Hao Zhou, Tong-Cun Zhang, Wen-Jian Ma, Xue-Gang Luo
Purpose: We previously found that the histone methyltransferase suppressor of variegation, enhancer of zeste, trithorax and myeloid-nervy-deformed epidermal autoregulatory factor-1 domain-containing protein 3 (SMYD3) is a potential independent predictive factor or prognostic factor for overall survival in gastric cancer patients, but its roles seem to differ from those in other cancers. Therefore, in this study, the detailed functions of SMYD3 in cell proliferation and migration in gastric cancer were examined...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29302369/long-term-follow-up-for-type-2-diabetes-mellitus-after-gastrectomy-in-non-morbidly-obese-patients-with-gastric-cancer-the-legitimacy-of-onco-metabolic-surgery
#10
Tae-Hoon Lee, Chang Min Lee, Sungsoo Park, Do Hyun Jung, You Jin Jang, Jong-Han Kim, Seong-Heum Park, Young-Jae Mok
Purpose: This study primarily aimed to investigate the short- and long-term remission rates of type 2 diabetes (T2D) in patients who underwent surgical treatment for gastric cancer, especially patients who were non-obese, and secondarily to determine the potential factors associated with remission. Materials and Methods: We retrospectively reviewed the clinical records of patients with T2D who underwent radical gastrectomy for gastric cancer, from January 2008 to December 2012...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28970959/erratum-anthropometric-study-of-the-stomach
#11
Eun-Gyeong Lee, Tae-Han Kim, Yeon-Ju Huh, Yun-Suhk Suh, Hye-Sung Ahn, Seong-Ho Kong, Hyuk-Joon Lee, Woo Ho Kim, Han-Kwang Yang
[This corrects the article on p. 247 in vol. 16, PMID: 28053811.].
September 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28970958/plexiform-angiomyxoid-myofibroblastic-tumor-of-the-stomach-a-rare-case
#12
Su Mi Kim, Ji Yeong An, Min-Gew Choi, Jun Ho Lee, Tae Sung Sohn, Kyung-Mee Kim, Sung Kim, Jae Moon Bae
Plexiform angiomyxoid myofibroblastic tumor (PAMT) of the stomach is a very rare mesenchymal tumor of the gastrointestinal tract. We report a case of asymptomatic gastric PAMT that was pathologically confirmed after surgical resection. The tumor had a multinodular plexiform growth pattern, bland-looking spindle cells, and an Alcian blue-positive myxoid stromal matrix rich in small blood vessels. Immunohistochemistry analysis revealed that the tumor cells of the PAMT were positive for smooth muscle actin (SMA) and negative for c-kit, CD34, S-100 protein, epithelial membrane antigen (EMA), and desmin...
September 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28970957/two-layer-hand-sewn-esophagojejunostomy-in-totally-laparoscopic-total-gastrectomy-for-gastric-cancer
#13
Enrique Norero, Rodrigo Muñoz, Marco Ceroni, Manuel Manzor, Fernando Crovari, Mauricio Gabrielli
PURPOSE: Different esophagojejunostomy (EJ) reconstruction methods are used after totally laparoscopic total gastrectomy (TLTG), and none is considered a standard technique. This report describes a 2-layer hand-sewn EJ technique during TLTG; we also evaluated postoperative morbidity associated with this technique. MATERIALS AND METHODS: This retrospective cohort study included all consecutive patients who underwent TLTG for gastric cancer (GC) from 2012 to 2016 at 2 affiliated teaching hospitals...
September 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28970956/a-novel-roux-en-y-reconstruction-involving-the-use-of-two-circular-staplers-after-distal-subtotal-gastrectomy-for-gastric-cancer
#14
Hoon Hur, Chang Wook Ahn, Cheul Su Byun, Ho Jung Shin, Young Bae Kim, Sang-Yong Son, Sang-Uk Han
PURPOSE: Although Roux-en-Y (R-Y) reconstruction after distal gastrectomy has several advantages, such as prevention of bile reflux into the remnant stomach, it is rarely used because of the technical difficulty. This prospective randomized clinical trial aimed to show the efficacy of a novel method of R-Y reconstruction involving the use of 2 circular staplers by comparing this novel method to Billroth-I (B-I) reconstruction. MATERIALS AND METHODS: A total of 118 patients were randomly allocated into the R-Y (59 patients) and B-I reconstruction (59 patients) groups...
September 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28970955/does-hospital-volume-really-affect-the-surgical-and-oncological-outcomes-of-gastric-cancer-in-korea
#15
Eun Young Kim, Kyo Young Song, Junhyun Lee
PURPOSE: The significance of hospital volume remains inconsistent and controversial. In particular, few studies have examined whether hospital volume is associated with the outcome of gastrectomy for gastric cancer in East Asia. This study examined the effect of hospital volume on the short-term surgical and long-term oncological outcomes of patients undergoing curative gastrectomy for gastric cancer. MATERIALS AND METHODS: Between 2009 and 2011, 1,561 patients underwent curative gastrectomy for gastric cancer at Seoul St...
September 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28970954/laparoscopic-gastrectomy-performed-by-an-expert-in-open-gastrectomy
#16
Kyong-Choun Chi, Joong-Min Park
PURPOSE: Senior surgeons prefer open gastrectomy (OG), while young surgeons prefer laparoscopic gastrectomy (LG). The purpose of this study was to evaluate the surgical outcomes of LG performed by a senior surgeon who was an expert in OG during his learning period, by comparing them with LGs performed by a young surgeon. MATERIALS AND METHODS: A senior surgeon performed 50 curative gastrectomies with laparoscopy (LG-S group) from March 2015 to August 2016. A young surgeon's initial 50 LGs comprised the LG-Y group...
September 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28970953/overexpression-of-neuron-specific-enolase-as-a-prognostic-factor-in-patients-with-gastric-cancer
#17
Taejin Park, Young-Joon Lee, Sang-Ho Jeong, Sang-Kyung Choi, Eun-Jung Jung, Young-Tae Ju, Chi-Young Jeong, Miyeong Park, Young-Sool Hah, Jiyun Yoo, Woo-Song Ha, Soon-Chan Hong, Gyung Hyuck Ko
PURPOSE: Enolase is a cytoplasmic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway. The aim of this study was to investigate whether the overexpression of neuron-specific enolase (NSE) can serve as a prognostic factor in patients with gastric cancer (GC). MATERIALS AND METHODS: To assess its prognostic value in GC, NSE expression was measured by immunohistochemistry in a clinically annotated tissue microarray comprising of 327 human GC specimens...
September 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28970952/a-promising-method-for-tumor-localization-during-total-laparoscopic-distal-gastrectomy-preoperative-endoscopic-clipping-based-on-negative-biopsy-and-selective-intraoperative-radiography-findings
#18
Joo Weon Chung, Kyung Won Seo, Kyoungwon Jung, Moo In Park, Sung Eun Kim, Seun Ja Park, Sang Ho Lee, Yeon Myung Shin
PURPOSE: Precise localization of tumors and creation of sufficient proximal resection margins are complicated processes during total laparoscopic distal gastrectomy (TLDG) for clinical T1/T2 gastric cancers. Various solutions to this problem have also yielded many disadvantages. In this study, we reviewed a preoperative endoscopic clipping method based on the results of negative biopsy and selective intraoperative radiography. MATERIALS AND METHODS: A retrospective review of 345 consecutive patients who underwent TLDG and preoperative endoscopic clipping for tumor localization was conducted...
September 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28970951/comparison-of-the-differences-in-survival-rates-between-the-7th-and-8th-editions-of-the-ajcc-tnm-staging-system-for-gastric-adenocarcinoma-a-single-institution-study-of-5-507-patients-in-korea
#19
Sung Geun Kim, Ho Seok Seo, Han Hong Lee, Kyo Yong Song, Cho Hyun Park
PURPOSE: The aims of this study were to compare the 7th and 8th editions of the American Joint Committee on Cancer (AJCC) staging manuals on tumor, node, and metastasis (TNM) staging systems and to evaluate whether the 8th edition represents a better refinement of the 7th staging system, when applied for the classification of gastric cancers. MATERIALS AND METHODS: A total of 5,507 gastric cancer patients, who underwent treatment from January 1989 to December 2013 at a single institute, were included...
September 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28970950/external-validation-of-a-gastric-cancer-nomogram-derived-from-a-large-volume-center-using-dataset-from-a-medium-volume-center
#20
Pyeong Su Kim, Kyung-Muk Lee, Dong-Seok Han, Moon-Won Yoo, Hye Seung Han, Han-Kwang Yang, Ho Yoon Bang
PURPOSE: Recently, a nomogram predicting overall survival after gastric resection was developed and externally validated in Korea and Japan. However, this gastric cancer nomogram is derived from large-volume centers, and the applicability of the nomogram in smaller centers must be proven. The purpose of this study is to externally validate the gastric cancer nomogram using a dataset from a medium-volume center in Korea. MATERIALS AND METHODS: We retrospectively analyzed 610 patients who underwent radical gastrectomy for gastric cancer from August 1, 2005 to December 31, 2011...
September 2017: Journal of Gastric Cancer
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