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Journal of Gastric Cancer

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https://www.readbyqxmd.com/read/28680724/five-year-survival-associated-with-stage-i-gastric-cancer-after-resection-of-early-recurrence-at-nodal-station-no-14v-a-case-report
#1
Iku Abe, Takahiro Kinoshita, Akio Kaito, Hideki Sunagawa, Masahiro Watanabe, Shizuki Sugita, Akiko Tonouchi, Reo Sato
The role of nodal station No. 14v (along the superior mesenteric vein) in lymphadenectomy for distal gastric cancer remains elusive. A 73-year-old woman underwent endoscopic submucosal dissection for gastric cancer, and was referred to our division for additional surgery because of pathologically non-curative resection. A laparoscopic distal gastrectomy with D1+ dissection was performed, with a final diagnosis of pT1bN1M0, Stage IB (2 nodal metastases to No. 6). Four months post-surgery, abdominal computed tomography revealed a 14-mm solitary nodule along the superior mesenteric vein...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28680723/gastric-adenocarcinoma-secondary-to-primary-gastric-diffuse-large-b-cell-lymphoma
#2
Riwa Sakr, Marcel Massoud, Georges Aftimos, Georges Chahine
Despite the decreasing incidence and mortality from gastric cancer, it remains a major health problem worldwide. Ninety percent of cases are adenocarcinomas. Here, we report a case of gastric adenocarcinoma developed after successful treatment of prior primary gastric diffuse large B-cell lymphoma (DLBCL). Our patient was an elderly man with primary gastric DLBCL in whom complete remission was achieved after R-CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone plus rituximab) chemotherapy. Helicobacter pylori infection persisted despite adequate treatment leading to sustained chronic gastritis...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28680722/botulinum-toxin-injection-for-the-treatment-of-delayed-gastric-emptying-following-pylorus-preserving-gastrectomy-an-initial-experience
#3
Jung Hwan Lee, Chan Gyoo Kim, Young-Woo Kim, Il Ju Choi, Jong Yeul Lee, Soo-Jeong Cho, Young-Il Kim, Bang Wool Eom, Hong Man Yoon, Keun Won Ryu
PURPOSE: To report our experience of endoscopic botulinum toxin injection in patients who experienced severe delayed gastric emptying after pylorus-preserving gastrectomy (PPG). MATERIALS AND METHODS: We reviewed the medical records of 6 patients who received the botulinum toxin injection. They presented with severe delayed gastric emptying in the early postoperative period. Endoscopic botulinum toxin was administered as 4 injections of 25-50 IU into each of the 4 quadrants of the prepyloric area...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28680721/clinicopathological-features-and-survival-of-patients-with-gastric-cancer-with-a-family-history-a-large-analysis-of-2-736-patients-with-gastric-cancer
#4
Oh Jeong, Mi Ran Jung, Young Kyu Park, Seong Yeob Ryu
PURPOSE: Previous studies indicated conflicting results regarding the prognosis of gastric cancer with a family history (FHX). This study aimed to determine the clinicopathological features and survival of patients with gastric cancer with a FHX. MATERIALS AND METHODS: We reviewed 2,736 patients with gastric cancer who underwent surgery between 2003 and 2009. The prognostic value of a FHX was determined in the multivariate model after adjusting for variables in the Asian and internationally validated prognostic models...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28680720/multiple-primary-malignancies-in-patients-with-multiple-early-gastric-cancer
#5
Dae Hoon Kim, Su Mi Kim, Min Gew Choi, Tae Sung Sohn, Jae Moon Bae, Sung Kim
PURPOSE: This study aimed to investigate the correlation between multiple early gastric cancer (MEGC) and multiple primary malignancies during the follow-up of patients with gastrectomy. MATERIALS AND METHODS: The number of primary tumors detected in other organs after gastrectomy for early gastric cancer (EGC) has been increasing because of improved survival and surveillance programs. A total of 3,129 patients underwent radical gastrectomy for treatment of EGC at Samsung Medical Center from January 2000 to December 2005...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28680719/real-time-vessel-navigation-using-indocyanine-green-fluorescence-during-robotic-or-laparoscopic-gastrectomy-for-gastric-cancer
#6
Mina Kim, Sang-Yong Son, Long-Hai Cui, Ho-Jung Shin, Hoon Hur, Sang-Uk Han
PURPOSE: Identification of the infrapyloric artery (IPA) type is a key component of pylorus-preserving gastrectomy. As the indocyanine green (ICG) fluorescence technique is known to help visualize blood vessels and flow during reconstruction, we speculated that this emerging technique would be helpful in identifying the IPA type. MATERIALS AND METHODS: From August 2015 to February 2016, 20 patients who underwent robotic or laparoscopic gastrectomy were prospectively enrolled...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28680718/prognostic-factor-analysis-of-overall-survival-in-gastric-cancer-from-two-phase-iii-studies-of-second-line-ramucirumab-regard-and-rainbow-using-pooled-patient-data
#7
Charles S Fuchs, Kei Muro, Jiri Tomasek, Eric Van Cutsem, Jae Yong Cho, Sang-Cheul Oh, Howard Safran, György Bodoky, Ian Chau, Yasuhiro Shimada, Salah-Eddin Al-Batran, Rodolfo Passalacqua, Atsushi Ohtsu, Michael Emig, David Ferry, Kumari Chandrawansa, Yanzhi Hsu, Andreas Sashegyi, Astra M Liepa, Hansjochen Wilke
PURPOSE: To identify baseline prognostic factors for survival in patients with disease progression, during or after chemotherapy for the treatment of advanced gastric or gastroesophageal junction (GEJ) cancer. MATERIALS AND METHODS: We pooled data from patients randomized between 2009 and 2012 in 2 phase III, global double-blind studies of ramucirumab for the treatment of advanced gastric or GEJ adenocarcinoma following disease progression on first-line platinum- and/or fluoropyrimidine-containing therapy (REGARD and RAINBOW)...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28680717/effect-of-a-proton-pump-inhibitor-on-tumor-bleeding-prevention-in-unresectable-gastric-cancer-patients-a-double-blind-randomized-placebo-controlled-trial
#8
Young-Il Kim, Mi-Jung Kim, Sook Ryun Park, Hark Kyun Kim, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Gwang Ha Kim, Moo In Park, Byung-Ho Nam, Young Iee Park, Il Ju Choi
PURPOSE: Tumor bleeding is a major complication in inoperable gastric cancer. The study aim was to investigate the effects of proton pump inhibitor (PPI) treatment for the prevention of gastric tumor bleeding. MATERIALS AND METHODS: This study was a prospective double-blind, randomized, placebo-controlled trial. Patients with inoperable gastric cancer were randomly assigned to receive oral lansoprazole (30 mg) or placebo daily. The primary endpoint was the occurrence of tumor bleeding, and the secondary endpoints were transfusion requirement and overall survival (OS)...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28680716/chronological-changes-in-quality-of-life-after-distal-gastrectomy-for-gastric-cancer
#9
Ki Bum Park, Seung Soo Lee, Oh Kyoung Kwon, Ho Young Chung, Wansik Yu
PURPOSE: Patient quality of life (QoL) may be severely disrupted following distal gastrectomy for gastric cancer. This issue should be addressed to improve postoperative care. MATERIALS AND METHODS: QoL data from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, and its gastric cancer-specific module, were administered to 202 patients preoperatively, and 5 years postoperatively. Patients were classified into subgroups based on their answers to each questionnaire item: group I (good), answering "not at all"; group II (fair), answering "a little"; group III (poor), answering "quite a bit" or "very much...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28680715/actual-5-year-nutritional-outcomes-of-patients-with-gastric-cancer
#10
Ki Hyun Kim, Dong Jin Park, Young Suk Park, Sang Hoon Ahn, Do Joong Park, Hyung Ho Kim
PURPOSE: In this study, we aimed to evaluate the rarely reported long-term nutritional results of patients with gastric cancer after curative gastrectomy. MATERIALS AND METHODS: We retrospectively reviewed the prospectively collected medical records of 658 patients who underwent radical gastrectomy with curative intent for gastric cancer from January 2008 to December 2009 and had no recurrences. All patients were followed for 5 years. Nutritional statuses were assessed using measurements of body weight, serum hemoglobin, total lymphocyte count (TLC), protein, albumin, cholesterol, and nutritional risk index (NRI)...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28337367/a-case-of-advanced-gastric-cancer-with-para-aortic-lymph-node-metastasis-from-co-occurring-prostate-cancer
#11
Miyeong Park, Sang-Ho Jeong, Young-Joon Lee, Ji-Ho Park, Sang-Kyung Choi, Soon-Chan Hong, Eun-Jung Jung, Young-Tae Ju, Chi-Young Jeong, Jeong-Hee Lee, Woo-Song Ha
An 84-year-old man was diagnosed with two synchronous adenocarcinomas, a Borrmann type IV advanced gastric adenocarcinoma in his antrum and a well-differentiated Borrmann type I carcinoma on the anterior wall of the higher body of his stomach. Pre-operatively, computed tomography of the abdomen revealed the presence of advanced gastric cancer with peri-gastric and para-aortic lymph node (LN) metastasis. He planned for palliative total gastrectomy owing to the risk of obstruction by the antral lesion. We performed a frozen biopsy of a para-aortic LN during surgery and found that the origin of the para-aortic LN metastasis was from undiagnosed prostate cancer...
March 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28337366/natural-history-of-early-gastric-cancer-a-case-report-and-literature-review
#12
Tomohiro Iwai, Masao Yoshida, Hiroyuki Ono, Naomi Kakushima, Kohei Takizawa, Masaki Tanaka, Noboru Kawata, Sayo Ito, Kenichiro Imai, Kinichi Hotta, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi
Early detection and treatment decrease the mortality rate associated with gastric cancer (GC). However, the natural history of GC remains unclear. An 85-year-old woman was referred to our hospital for evaluation of a gastric tumor. Esophagogastroduodenoscopy identified a 6 mm, flat-elevated lesion at the lesser curvature of the antrum. A biopsy specimen showed a well-differentiated tubular adenocarcinoma. The depth of the lesion was estimated to be intramucosal. Although the lesion met the indications for endoscopic resection, periodic endoscopic follow-up was performed due to the patient's advanced age and comorbidities...
March 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28337365/body-composition-as-a-prognostic-factor-of-neoadjuvant-chemotherapy-toxicity-and-outcome-in-patients-with-locally-advanced-gastric-cancer
#13
Carolina Palmela, Sónia Velho, Lisa Agostinho, Francisco Branco, Marta Santos, Maria Pia Costa Santos, Maria Helena Oliveira, João Strecht, Rui Maio, Marília Cravo, Vickie E Baracos
PURPOSE: Neoadjuvant chemotherapy has been shown to improve survival in locally advanced gastric cancer, but it is associated with significant toxicity. Sarcopenia and sarcopenic obesity have been studied in several types of cancers and have been reported to be associated with higher chemotherapy toxicity and morbi-mortality. The aim of this study was to assess the prevalence of sarcopenia/sarcopenic obesity in patients with gastric cancer, as well as its association with chemotherapy toxicity and long-term outcomes...
March 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28337364/surgical-outcomes-associated-with-operable-gastric-cancer-in-a-tertiary-care-indian-hospital
#14
Joshua Franklyn, Sam V George, Myla Yacob, Vijay Abraham, Sudhakar Chandran, Tunny Sebastian, Inian Samarasam
PURPOSE: Data on operable gastric cancer from India is sparse. The purpose of this study was to investigate the clinical details, histopathological demographics, and 5-year overall survival (OS) and disease free survival (DFS) associated with operable, non-metastatic gastric cancer in a dedicated upper gastrointestinal (GI) surgical unit in India. MATERIALS AND METHODS: Data for patients diagnosed with operable gastric cancer between January 2006 and December 2014 were retrospectively analyzed...
March 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28337363/epidemiologic-study-of-human-epidermal-growth-factor-receptor-2-expression-in-advanced-metastatic-gastric-cancer-an-assessment-of-human-epidermal-growth-factor-receptor-2-status-in-tumor-tissue-samples-of-gastric-and-gastro-esophageal-junction-cancer
#15
Kyung Won Seo, Taeyong Jeon, Sewon Kim, Sung Soo Kim, Kwanghee Kim, Byoung-Jo Suh, Sunhwi Hwang, SeongHee Choi, Seungwan Ryu, Jae Seok Min, Young-Joon Lee, Ye Seob Jee, Hyeondong Chae, Doo Hyun Yang, Sang Ho Lee
PURPOSE: The Trastuzumab for gastric cancer (GC) trial identified human epidermal growth factor receptor 2 (HER2) as a predictor of successful treatment with trastuzumab (HER2 receptor targeting agent) among patients with advanced/metastatic GC. To date, the prevalence of HER2 overexpression in the Korean population is unknown. The present study aimed to assess the incidence of HER2 positivity among GC and gastroesophageal (GE) junction cancer samples and the relationship between HER2 overexpression and clinicopathological characteristics in Korean patients...
March 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28337362/analysis-of-g3bp1-and-vezt-expression-in-gastric-cancer-and-their-possible-correlation-with-tumor-clinicopathological-factors
#16
Mohammadreza Beheshtizadeh, Elham Moslemi
PURPOSE: This study aimed to analyze G3BP1 and VEZT expression profiles in patients with gastric cancer, and examine the possible relationship between the expressions of each gene and clinicopathological factors. MATERIALS AND METHODS: Expression of these genes in formalin-fixed paraffin embedded (FFPE) tissues, collected from 40 patients with gastric cancer and 40 healthy controls, was analyzed. Differences in gene expression among patient and normal samples were identified using the GraphPad Prism 5 software...
March 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28337361/the-effect-of-endoscopic-resection-on-short-term-surgical-outcomes-in-patients-with-additional-laparoscopic-gastrectomy-after-non-curative-resection-for-gastric-cancer
#17
Eun-Gyeong Lee, Keun-Won Ryu, Bang-Wool Eom, Hong-Man Yoon, Yong-Il Kim, Soo-Jeong Cho, Jong-Yeul Lee, Chan-Gyoo Kim, Il-Ju Choi, Young-Woo Kim
PURPOSE: Endoscopic submucosal dissection (ESD) in early gastric cancer causes an artificial gastric ulcer and local inflammation that has a negative intraprocedural impact on additional laparoscopic gastrectomy in patients with noncurative ESD. In this study, we analyzed the effect of ESD on short-term surgical outcomes and evaluated the risk factors. MATERIALS AND METHODS: From January 2003 to January 2013, 1,704 patients of the National Cancer Center underwent laparoscopic gastrectomy with lymph node dissection because of preoperative stage Ia or Ib gastric cancer...
March 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28337360/perioperative-epirubicin-oxaliplatin-and-capecitabine-chemotherapy-in-locally-advanced-gastric-cancer-safety-and-feasibility-in-an-interim-survival-analysis
#18
Vikas Ostwal, Arvind Sahu, Anant Ramaswamy, Bhawna Sirohi, Subhadeep Bose, Vikas Talreja, Mahesh Goel, Shraddha Patkar, Ashwin Desouza, Shailesh V Shrikhande
PURPOSE: Perioperative chemotherapy improves survival outcomes in locally advanced (LA) gastric cancer. MATERIALS AND METHODS: We retrospectively analyzed patients with LA gastric cancer who were offered perioperative chemotherapy consisting of epirubicin, oxaliplatin, and capecitabine (EOX) from May 2013 to December 2015 at Tata Memorial Hospital in Mumbai. RESULTS: Among the 268 consecutive patients in our study, 260 patients (97.0%) completed neoadjuvant chemotherapy, 200 patients (74...
March 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28337359/effect-of-acupuncture-on-postoperative-ileus-after-distal-gastrectomy-for-gastric-cancer
#19
Se Yun Jung, Hyun Dong Chae, Ung Rae Kang, Min Ah Kwak, In Hwan Kim
PURPOSE: Acupuncture has recently been accepted as a treatment option for managing postoperative ileus (POI) and various functional gastrointestinal disorders. Therefore, we conducted a prospective randomized study to evaluate the effect of acupuncture on POI and other surgical outcomes in patients who underwent gastric surgery. MATERIALS AND METHODS: Thirty-six patients who underwent distal gastrectomy for gastric cancer from March to December 2015 were randomly assigned to acupuncture or non-acupuncture (NA) groups at 1:1 ratio...
March 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28337358/gastric-cancer-and-angiogenesis-is-vegf-a-useful-biomarker-to-assess-progression-and-remission
#20
REVIEW
Filipa Macedo, Kátia Ladeira, Adhemar Longatto-Filho, Sandra F Martins
Gastric cancer (GC) has high mortality owing to its aggressive nature. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of GC. The aim of this work was to review the angiogenic biomarkers related to the behavior of GC, documented in the literature. A search of the PubMed database was conducted with the MeSH terms: "Stomach neoplasms/blood [MeSH] or stomach neoplasms/blood supply [MeSH] and angiogenic proteins/blood [Major]". A total of 30 articles were initially collected, and 4 were subsequently excluded...
March 2017: Journal of Gastric Cancer
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