journal
MENU ▼
Read by QxMD icon Read
search

Pharmacognosy Research

journal
https://www.readbyqxmd.com/read/27695274/effects-of-curcuma-xanthorrhiza-extracts-and-their-constituents-on-phase-ii-drug-metabolizing-enzymes-activity
#1
Nurul Afifah Mohd Salleh, Sabariah Ismail, Mohd Rohaimi Ab Halim
BACKGROUND: Curcuma xanthorrhiza is a native Indonesian plant and traditionally utilized for a range of illness including liver damage, hypertension, diabetes, and cancer. OBJECTIVE: The study determined the effects of C. xanthorrhiza extracts (ethanol and aqueous) and their constituents (curcumene and xanthorrhizol) on UDP-glucuronosyltransferase (UGT) and glutathione transferase (GST) activities. MATERIALS AND METHODS: The inhibition studies were evaluated both in rat liver microsomes and in human recombinant UGT1A1 and UGT2B7 enzymes...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695273/antihyperglycemic-and-insulin-secretagogue-activities-of-abrus-precatorius-leaf-extract
#2
Balekari Umamahesh, Ciddi Veeresham
AIM: Abrus precatorius leaves methanolic extract (APME) was evaluated for in vivo antihyperglycemic activity and in vitro insulinotropic effect. MATERIALS AND METHODS: In vivo antihyperglycemic and insulin secretagogue activities were assessed in streptozotocin-induced diabetic rats by oral administration of APME (200 mg/kg body weight [bw]) for 28 days. In vitro insulin secretion mechanisms were studied using mouse insulinoma beta cells (MIN6-β). In vivo body weight and blood glucose and in vivo and in vitro insulin levels were estimated...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695272/wound-healing-activity-of-silibinin-in-mice
#3
Rojalini Samanta, Ashok K Pattnaik, Kishanta K Pradhan, Beena K Mehta, Shakti P Pattanayak, Sugato Banerjee
BACKGROUND: Silibinin is a semi-purified fraction of silymarin contained in milk thistle (Silybum marianum Asteraceae). Primarily known for its hepatoprotective actions, silymarin may also stimulate epithelialization and reduce inflammation in excision wound. Previous studies show antioxidant, anti-inflammatory, and antimicrobial actions of silibinin. However, wound healing property of silibinin is not well studied. OBJECTIVE: This study investigates wound healing activity of silibinin topical formulation...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695271/inhibition-of-human-cytochrome-p450-2c8-catalyzed-amodiaquine-n-desethylation-effect-of-five-traditionally-and-commonly-used-herbs
#4
Yasotha Devi Muthiah, Chin Eng Ong, Siti Amrah Sulaiman, Rusli Ismail
BACKGROUND: In Southeast Asia and many parts of the world, herbal products are increasingly used in parallel with modern medicine. OBJECTIVE: This study aimed to investigate the effects of herbs commonly used in Southeast Asia on activity of cytochrome P450 2C8 (CYP2C8), an important human hepatic enzyme in drug metabolism. MATERIALS AND METHODS: The selected herbs, such as Eurycoma longifolia Jack (ELJ), Labisia pumila (LP), Echinacea purpurea (EP), Andrographis paniculata (AP), and Ginkgo biloba (GB), were subjected to inhibition studies using an in vitro CYP2C8 activity marker, amodiaquine N-desethylase assay...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695270/bioactivity-of-diterpens-from-the-ethyl-acetate-extract-of-kingiodendron-pinnatum-rox-hams
#5
Komal Kumar Javarappa, Attemode Girijanna Devi Prasad, A J Mahadesh Prasad, Chetana Mane
BACKGROUND: Kingiodendron pinnatum Rox. Hams. is an endangered medicinal plant used in gonorrhoe, catarrhal conditions of genito-urinary and respiratory tracts. The scientific and pharmacological formulation of K. pinnatum has not been established so far though it is being traditionally used by tribes of the region. OBJECTIVE: P hytochemical screening and identification of the bioactive compounds from the ethyl acetate extract of Kingiodendron pinnatum Rox. Hams...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695269/elucidation-of-flavonoids-from-carissa-congesta-polyalthia-longifolia-and-benincasa-hispida-plant-extracts-by-hyphenated-technique-of-liquid-chromatography-mass-spectroscopy
#6
Gaurav M Doshi, Vivek V Nalawade, Aaditi S Mukadam, Pratip K Chaskar, Sandeep P Zine, Rakesh R Somani, Hemant D Une
BACKGROUND: Carissa congesta (CC), Polyalthia longifolia (PL), and Benincasa hispida (BH) are economically important plants. OBJECTIVE: Current research encompasses identification of quercetin and rutin and their analogues by liquid chromatography-mass spectroscopy (LC-MS) from the selected plant species. MATERIALS AND METHODS: Fresh roots, leaves, and seeds of CC, PL, and BH plants respectively were shade-dried followed by extraction and elucidation of rutin and quercetin by LC-MS...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695268/anti-advanced-glycation-end-product-and-free-radical-scavenging-activity-of-plants-from-the-yucatecan-flora
#7
Wendy Del C Dzib-Guerra, Fabiola Escalante-Erosa, Karlina García-Sosa, Séverine Derbré, Patricia Blanchard, Pascal Richomme, Luis M Peña-Rodríguez
BACKGROUND: Formation and accumulation of advanced glycation end-products (AGE) is recognized as a major pathogenic process in diabetic complications, atherosclerosis and cardiovascular diseases. In addition, reactive oxygen species and free radicals have also been reported to participate in AGE formation and in cell damage. Natural products with antioxidant and antiAGE activity have great therapeutic potential in the treatment of diabetes, hypertension and related complications. Objective: to test ethanolic extracts and aqueous-traditional preparations of plants used to treat diabetes, hypertension and obesity in Yucatecan traditional medicine for their anti-AGE and free radical scavenging activities...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695267/influence-of-the-extractive-method-on-the-recovery-of-phenolic-compounds-in-different-parts-of-hymenaea-martiana-hayne
#8
Fernanda Granja da Silva Oliveira, Sarah Raquel Gomes de Lima-Saraiva, Ana Paula Oliveira, Suzana Vieira Rabêlo, Larissa Araújo Rolim, Jackson Roberto Guedes da Silva Almeida
BACKGROUND: Popularly known as "jatobá," Hymenaea martiana Hayne is a medicinal plant widely used in the Brazilian Northeast for the treatment of various diseases. OBJECTIVE: The aim of this study was to evaluate the influence of different extractive methods in the production of phenolic compounds from different parts of H. martiana. MATERIALS AND METHODS: The leaves, bark, fruits, and seeds were dried, pulverized, and submitted to maceration, ultrasound, and percolation extractive methods, which were evaluated for yield, visual aspects, qualitative phytochemical screening, phenolic compound content, and total flavonoids...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695266/evaluation-of-in-vitro-antiviral-activity-of-datura-metel-linn-against-rabies-virus
#9
Soumen Roy, Sandeepan Mukherjee, Sandip Pawar, Abhay Chowdhary
OBJECTIVE: The soxhlet and cold extracts of Datura metel Linn. were evaluated for in vitro antirabies activity. MATERIALS AND METHODS: Soxhlet and cold extraction method were used to extract Datura (fruit and seed) extracts. In vitro cytotoxicity assay was performed by 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide assay. Based on the CC50 range, the in vitro antirabies activity of the extracts was screened by rapid fluorescent focus inhibition test and molecular method...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695265/in-vitro-antioxidant-activities-and-polyphenol-contents-of-seven-commercially-available-fruits
#10
Paramita Basu, Camelia Maier
BACKGROUND: Fruits are considered one of the richest sources of natural antioxidants. Their consumption has been linked to the prevention of oxidative stress-induced diseases. OBJECTIVE: In this study, in vitro antioxidant activities of blueberry, jackfruit, blackberry, black raspberry, red raspberry, strawberry, and California table grape extracts were evaluated. MATERIALS AND METHODS: Antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant potential (FRAP), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), nitric oxide (NO), superoxide anion (O2(-)) scavenging assays, and ferric reducing power...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695264/chemical-characterization-and-cytoprotective-effect-of-the-hydroethanol-extract-from-annona-coriacea-mart-araticum
#11
José G A S Júnior, Henrique D M Coutinho, Ticiana C C Boris, Janyketchuly S Cristo, Nara L F Pereira, Fernando G Figueiredo, Francisco A B Cunha, Pedro E A Aquino, Polyana A C Nascimento, Francisco J C Mesquita, Paulo H F Moreira, Sáskia T B Coutinho, Ivon T Souza, Gabriela C Teixeira, Najla M N Ferreira, Eleonora O Farina, Cícero M G Torres, Vanderlan N Holanda, Vandbergue S Pereira, Maria I F Guedes
INTRODUCTION: Annona coriacea Mart. (araticum) is a widely distributed tree in the cerrado. Its value is attributed principally to the consumption of its fruit which possesses a large nutritive potential. The objective was to identify the chemical profile and evaluate the antimicrobial and cytoprotective activity of the hydroethanol extract of A. coriacea Mart. (HEAC) leaves against the toxicity of mercury chloride. MATERIALS AND METHODS: The characterization of components was carried out using high-performance liquid chromatography (HPLC)...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695263/effect-of-musa-sapientum-stem-extract-on-animal-models-of-depression
#12
Aditya J Reddy, Shailendra S Handu, Ashok Kumar Dubey, Pramod Kumari Mediratta, Rimi Shukla, Qazi Mushtaq Ahmed
BACKGROUND: Musa sapientum, the banana plant, has shown to possess antioxidant activity in previous studies. Oxidative stress has been linked to the pathogenesis of major depressive disorder (MDD) with evidence of increased serum levels of oxidative stress biomarkers in MDD patients. OBJECTIVE: The present study aimed to evaluate the antidepressant activity of M. sapientum stem extract (MSSE) in experimental models in mice. MATERIALS AND METHODS: Forced swim test (FST) and tail suspension test (TST) were carried out in five different groups (n = 6/group) of mice...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695262/kayeassamin-a-isolated-from-the-flower-of-mammea-siamensis-triggers-apoptosis-by-activating-caspase-3-8-in-hl-60-human-leukemia-cells
#13
Takuhiro Uto, Nguyen Huu Tung, Pinjutha Thongjankaew, Sorasak Lhieochaiphant, Yukihiro Shoyama
BACKGROUND: Mammea siamensis (Miq.) T. Anders. is used as a medicinal plant in Thailand and has several traditional therapeutic properties. In a previous study, we isolated eight compounds from the flower of M. siamensis and demonstrated that kayeassamin A (KA) exhibited potent antiproliferative activity against human leukemia and stomach cancer cell lines. OBJECTIVE: In this study, we investigated the effect of KA on cell viability and apoptotic mechanisms in HL-60 human leukemia cells...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695261/high-performance-thin-layer-chromatography-method-development-validation-and-simultaneous-quantification-of-four-compounds-identified-in-standardized-extracts-of-orthosiphon-stamineus
#14
Suzana Hashim, Hooi Kheng Beh, Mohamad Shahrul Ridzuan Hamil, Zhari Ismail, Amin Malik Shah Abdul Majid
CONTEXT: Orthosiphon stamineus is a medicinal herb widely grown in Southeast Asia and tropical countries. It has been used traditionally as a diuretic, abdominal pain, kidney and bladder inflammation, gout, and hypertension. AIMS: This study aims to develop and validate the high-performance thin layer chromatography (HPTLC) method for quantification of rosmarinic acid (RA), 3'-hydroxy-5,6,7,4'-tetramethoxyflavone (TMF), sinensitin (SIN) and eupatorin (EUP) found in ethanol, 50% ethanol and water extract of O...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695260/probing-regenerative-potential-of-moringa-oleifera-aqueous-extracts-using-in-vitro-cellular-assays
#15
Evangeline E Fernandes, Anubha V Pulwale, Gauri A Patil, Alpana S Moghe
BACKGROUND: Molecules stimulating regeneration and proliferation of cells are of significance in combating ailments caused due to tissue injury, inflammation, and degenerative disorders. Moringa oleifera is one of the most valued food plants having the profile of important nutrients and impressive range of medicinal uses. OBJECTIVE: To evaluate the potential of M. oleifera aqueous leaf and flower extracts to promote the proliferation of cells and explore their effect on cancer cell lines for assessment of safety...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695259/evaluation-of-antiulcer-and-antioxidant-activity-of-barleria-gibsonidalz-leaves
#16
Firoj A Tamboli, Harinath N More
BACKGROUND: Peptic ulcer is a digestive disorder most commonly found in clinical practice. Given the many side effects of modern medicine, the initial acquisition of fewer side effects, and medication of indigenous drugs, it should be considered as a better alternative for the treatment of peptic ulcer. OBJECTIVE: To assess antiulcer and antioxidant activity of ethanol extract of Barleria gibsoni (EBG) Dalz. leaves in ulcer-induced rats and in vitro antioxidants method, respectively...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27695258/in-vivo-study-on-depressant-effects-and-muscle-coordination-activity-of-galphimia-glauca-stem-methanol-extract
#17
Baba Shankar Rao Garige, Srisailam Keshetti, Uma Maheshwara Rao Vattikuti
BACKGROUND: Galphimia glauca is an evergreen shrub found across peninsular India, belonging to family Malpighiaceae. OBJECTIVE: The objective of this study was to assess the in vivo depressant effects and muscle coordination activity of G. glauca stem methanol extract (GGSME). MATERIALS AND METHODS: The stem methanol extract was administered in Swiss albino mice in 1 day to study the central nervous system (CNS) depressant and muscle coordination activity employing animal models such as sodium pentobarbital-induced sleep test, hole-board test, open field test, pentylenetetrazole (PTZ)-induced convulsions, picrotoxin-induced convulsions, grip strengthening test in mice, and Rota-rod test...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27365994/homeopathy-in-dentistry-is-there-a-role
#18
Ujwala Rohan Newadkar, Lalit Chaudhari, Yogita K Khalekar
No abstract text is available yet for this article.
July 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27365993/inhibition-of-group-iia-secretory-phospholipase-a2-and-its-inflammatory-reactions-in-mice-by-ethanolic-extract-of-andrographis-paniculata-a-well-known-medicinal-food
#19
V Kishore, N S Yarla, F Zameer, M N Nagendra Prasad, M S Santosh, S S More, D G Rao, Bhadrapura Lakkappa Dhananjaya
UNLABELLED: Andrographis paniculata Nees is an important medicinal plant found in the tropical regions of the world, which has been traditionally used in Indian and Chinese medicinal systems. It is also used as medicinal food. A. paniculata is found to exhibit anti-inflammatory activities; however, its inhibitory potential on inflammatory Group IIA phospholipases A2 (PLA2) and its associated inflammatory reactions are not clearly understood. The aim of the present study is to evaluate the inhibitory/neutralizing potential of ethanolic extract of A...
July 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27365992/evaluating-the-anticancer-potential-of-ethanolic-gall-extract-of-terminalia-chebula-gaertn-retz-combretaceae
#20
B E Ravi Shankara, Y L Ramachandra, S Sundara Rajan, P S Sujan Ganapathy, Nagendra Sastry Yarla, S A Richard, Bhadrapura Lakkappa Dhananjaya
UNLABELLED: Plants have been an important source for discovery of anticancer compounds. With the current decline in the number of new molecular entities from the pharmaceutical industry, novel anticancer agents are being sought from traditional medicines; therefore the anticancer efficacy of many plants that are used in traditional medicine is yet to be verified. The objective of the study was to evaluate the cytotoxic potential of ethanolic leaf gall extract of Terminalia chebula are evaluated against buffalo rat liver 3A, MCF-7 (Human mammary gland adenocarcinoma) and A-549 (Human lung cancer) cell lines...
July 2016: Pharmacognosy Research
journal
journal
43549
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"