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Pharmacognosy Research

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https://www.readbyqxmd.com/read/28250665/erratum-bioactivity-of-diterpens-from-the-ethyl-acetate-extract-of-kingiodendron-pinnatum-rox-hams
#1
(no author information available yet)
[This corrects the article on p. 287 in vol. 8, PMID: 27695270.].
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250664/potential-of-cannabidiol-for-the-treatment-of-viral-hepatitis
#2
Henry I C Lowe, Ngeh J Toyang, Wayne McLaughlin
Viral hepatitis B (HBV) and hepatitis C (HCV) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer. While HBV has a vaccine, HCV has none at the moment. The risk of drug resistance, combined with the high cost of current therapies, makes it a necessity for cost-effective therapeutics to be discovered and developed. The recent surge in interest in Medical Cannabis has led to interest in evaluating and validating the therapeutic potentials of Cannabis and its metabolites against various diseases including viruses...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250663/modulating-effect-of-hypnea-musciformis-red-seaweed-on-lipid-peroxidation-antioxidants-and-biotransforming-enzymes-in-7-12-dimethylbenz-a-anthracene-induced-mammary-carcinogenesis-in-experimental-animals
#3
Mohan Balamurugan, Kathiresan Sivakumar, Arokia Vijaya Anand Mariadoss, Kathiresan Suresh
BACKGROUND: Breast cancer is the second most widespread diagnosed cancer and second leading cause of cancer death in women. OBJECTIVE: The present work was carried out to evaluate the chemo preventive potential of Hypnea musciformis (ethanol extract) seaweed on oxidative stress markers, bio transforming enzymes, incidence of tumors, and pathological observation in 7,12-dimethylbenzanthracene (DMBA) exposed experimental mammary carcinogenesis. MATERIALS AND METHODS: Female Sprague-Dawley rats were randomly divided into four groups...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250662/synergisms-in-alpha-glucosidase-inhibition-and-antioxidant-activity-of-camellia-sinensis-l-kuntze-and-eugenia-uniflora-l-ethanolic-extracts
#4
Juliana Vinholes, Márcia Vizzotto
BACKGROUND: Camellia sinensis, the most consumed and popular beverages worldwide, and Eugenia uniflora, a Brazilian native species, have been already confirmed to have beneficial effects in the treatment of diabetes mellitus. However, their potential acting together against an enzyme linked to this pathology has never been exploited. OBJECTIVE: The aim of this study was to evaluate the inhibitory properties of individual and combined ethanolic extracts of the leaves of C...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250661/antifungal-activity-of-hydroalcoholic-extract-of-chrysobalanus-icaco-against-oral-clinical-isolates-of-candida-species
#5
João Paulo Bastos Silva, Ana Regina Maués Noronha Peres, Thiago Portal Paixão, Andressa Santa Brígida Silva, Ana Cristina Baetas, Wagner Luiz Ramos Barbosa, Marta Chagas Monteiro, Marcieni Ataíde Andrade
BACKGROUND: Chrysobalanus icaco is a medicinal plant commonly used to treat fungal infections in Brazilian Amazonian region. OBJECTIVE: This work aimed to evaluate the antifungal activity of the hydroalcoholic extract of C. icaco (HECi) against oral clinical isolates of Candida spp. and to determine the pharmacognostic parameters of the herbal drug and the phytochemical characteristics of HECi. MATERIALS AND METHODS: The pharmacognostic characterization was performed using pharmacopoeial techniques...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250660/the-hydroalcoholic-extract-of-matricaria-chamomilla-suppresses-migration-and-invasion-of-human-breast-cancer-mda-mb-468-and-mcf-7-cell-lines
#6
Mohsen Nikseresht, Ali Mohammad Kamali, Hamid Reza Rahimi, Hamdollah Delaviz, Mehdi Akbartabar Toori, Iraj Ragerdi Kashani, Reza Mahmoudi
BACKGROUND: Matricaria chamomilla is an aromatic plant with antioxidant, anticancer, and anti-inflammatory properties. However, the inhibitory role of M. chamomilla on migration and invasion of human breast cancer cells remains unclear. OBJECTIVE: This study investigated the methods to evaluate these anticancer mechanisms of M. chamomilla on human breast cancer MCF-7 and MDA-MB-468 cell lines. MATERIALS AND METHODS: The cells were treated with hydroalcoholic extract of M...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250659/antidiabetic-effects-of-aqueous-and-dichloromethane-methanol-stem-bark-extracts-of-pterocarpus-soyauxii-taub-papilionaceae-on-streptozotocin-induced-diabetic-rats
#7
Marie Claire Tchamadeu, Paul Désiré Djomeni Dzeufiet, Nelly Blaes, Jean-Pierre Girolami, Pierre Kamtchouing, Théophile Dimo
AIM OF THE STUDY: The aim is to evaluate the hypoglycemic and antidiabetic effects of aqueous and CH2Cl2/CH3OH stem bark extracts of Pterocarpus soyauxii Taub in normal and diabetic rats. MATERIALS AND METHODS: Streptozotocin (STZ)-induced diabetic and normal adult Wistar rats were orally administered with aqueous and CH2Cl2/CH3OH plant extracts of P. soyauxii at various doses (38-300 mg/kg) in a single administration. In addition, STZ-induced diabetic rats received prolonged daily administration for 14 days...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250658/growth-inhibition-and-morphological-alteration-of-fusarium-sporotrichioides-by-mentha-piperita-essential-oil
#8
P Rachitha, K Krupashree, G V Jayashree, Natarajan Gopalan, Farhath Khanum
OBJECTIVE: The aim of this study is to determine the phytochemical composition, antifungal activity of Mentha piperita essential oil (MPE) against Fusarium sporotrichioides. METHODS: The phytochemical composition was conducted by gas chromatography mass spectrometry (GC MS) analysis and mycelia growth inhibition was determined by minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), the morphological characterization was observed by scanning electron microscopy...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250657/short-term-effects-of-date-palm-extract-phoenix-dactylifera-on-ischemia-reperfusion-injury-induced-by-testicular-torsion-detorsion-in-rats
#9
Alireza Raayat Jahromi, Rokhsana Rasooli, Younes Kamali, Nasrollah Ahmadi, Ehsan Sattari
BACKGROUND: Antioxidants are potent scavengers of free radicals and have beneficial effects on human health. OBJECTIVE: The aim of this study was to investigate the potential protective antioxidant activity of the edible portion of date fruit extract in an experimental testicular torsion/detorsion (T/D) model in rats. MATERIALS AND METHODS: To investigate the potential protective effects of date palm (DP), 30 male Spraque-Dawley rats were divided into three groups: sham-operated, T/D, and T/D + DP-treated (500 mg/kg, PO) groups...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250656/new-cytotoxic-cembranoid-from-indonesian-soft-coral-sarcophyton-sp
#10
Hedi Indra Januar, Neviaty Putri Zamani, Dedi Soedharma, Ekowati Chasanah
CONTEXT: Sarcophyton is a soft coral species that contains various secondary metabolites with cytotoxic activity. The production of cytotoxic compounds in soft corals is suggested as their allelochemical to win space competition. Therefore, if a particular soft coral species dominates a reef area, it may suggest to contain interesting bioactive compounds. AIMS: This research aimed to characterize the cytotoxic compounds in dominant soft coral species (Sarcophyton sp...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250655/pharmacognostic-specifications-and-lawsone-content-of-lawsonia-inermis-leaves
#11
Rawiwan Charoensup, Thidarat Duangyod, Chanida Palanuvej, Nijsiri Ruangrungsi
BACKGROUND: Lawsonia inermis L. has been used as a traditional or folk medicine for the treatment of a wide range of skin infectious diseases. OBJECTIVE: The objective of this study was to determine the pharmacognostic specifications and lawsone contents of L. inermis leaves. MATERIALS AND METHODS: The pharmacognostic specifications of L. inermis leaves from 12 sources were evaluated according to the WHO guideline of quality control method for medicinal plant materials...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250654/insulin-plant-costus-pictus-extract-restores-thyroid-hormone-levels-in-experimental-hypothyroidism
#12
S Ashwini, Zachariah Bobby, M G Sridhar, C C Cleetus
BACKGROUND: The aim of the present study was to investigate the preventive effect of Costus pictus leaf extract in experimental hypothyroidism. MATERIALS AND METHODS: Forty male Wistar rats were randomly divided into four groups with ten rats in each group: Control (C), hypothyroid (H), control+extract (C+E), and hypothyroid+extract (H+E). Rats in C group did not receive any intervention throughout the experimental period. The rats in the C+E and H+E groups received pretreatment with C...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250653/cytotoxicity-studies-of-the-extracts-fractions-and-isolated-compound-of-pseudocedrela-kotschyi-on-cervical-cancer-hela-breast-cancer-mcf-7-and-skeletal-muscle-cancer-rd-cells
#13
Taiwo O Elufioye, Abolaji A Abdul, Jone O Moody
BACKGROUND: This study determined the cytotoxic effects of root and stem bark extracts, fractions, and isolated compounds derived from Pseudocedrela kotschyi on HeLa, MCF-7, and RD cells. MATERIALS AND METHODS: The cytotoxic activity was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay against three cell lines (RD, HeLa, and MCF 7) at concentrations ranging from 0.01 to 1000 μg/mL. Isolation of crude saponin was done from the most active ethyl acetate fraction and further purified using vacuum liquid chromatography and preparative thin layer chromatographic techniques...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250652/cosmeceutical-effects-of-galactomannan-fraction-from-arenga-pinnata-fruits-in-vitro
#14
Yanti, Madriena, Soegianto Ali
BACKGROUND: Cosmeceuticals refer to natural cosmetics with medical-like benefits due to their bioactive contents. Sugar palm fruit (Arenga pinnata) extract has been claimed for its anti-aging effect in vitro. However, its active compounds for cosmeceuticals is still unclear. OBJECTIVE: This study was aimed to extract galactomannan from A. pinnata fruits and test its efficacy for tyrosinase inhibition, antioxidant, and anti-photoaging activities in vitro. MATERIALS AND METHODS: Galactomannan from A...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250651/analysis-of-soluble-proteins-in-natural-cordyceps-sinensis-from-different-producing-areas-by-sodium-dodecyl-sulfate-polyacrylamide-gel-electrophoresis-and-two-dimensional-electrophoresis
#15
Chun-Hong Li, Hua-Li Zuo, Qian Zhang, Feng-Qin Wang, Yuan-Jia Hu, Zheng-Ming Qian, Wen-Jia Li, Zhi-Ning Xia, Feng-Qing Yang
BACKGROUND: As one of the bioactive components in Cordyceps sinensis (CS), proteins were rarely used as index components to study the correlation between the protein components and producing areas of natural CS. OBJECTIVE: Protein components of 26 natural CS samples produced in Qinghai, Tibet, and Sichuan provinces were analyzed and compared to investigate the relationship among 26 different producing areas. MATERIALS AND METHODS: Proteins from 26 different producing areas were extracted by Tris-HCl buffer with Triton X-100, and separated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and two-dimensional electrophoresis (2-DE)...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250650/chronic-intake-of-green-propolis-negatively-affecting-the-rat-testis
#16
Grasiela Dias de Campos Severi-Aguiar, Suellen Josine Pinto, Cristina Capucho, Camila Andrea Oliveira, Maria Aparecida Diamante, Renata Barbieri, Fabrícia Souza Predes, Heidi Dolder
BACKGROUND: Human and animal evidence suggests that environmental toxicants may have an adverse impact on male reproductive health, reducing the population's reproductive output. Owing to the renewed attraction for natural products, some of them constitute effective alternatives to mitigate these effects. Propolis is a candidate for this use because of its intrinsic properties. In many situations, it improved the testicular damage and alleviated the toxic effects induced by environmental contaminant exposure...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250649/evaluation-of-cholesterol-lowering-activity-of-standardized-extract-of-mangifera-indica-in-albino-wistar-rats
#17
G M Gururaja, Deepak Mundkinajeddu, A Senthil Kumar, Shekhar Michael Dethe, J Joshua Allan, Amit Agarwal
INTRODUCTION: Cholesterol lowering activity of Mangifera indica L. has been determined by earlier researchers and kernel, leaf and bark have shown significant activity. However, the specific cholesterol lowering activity of leaf methanol extract has not been determined. MATERIALS AND METHODS: The present study involved evaluation of cholesterol lowering potential of methanol extract of M. indica leaves using high cholesterol diet model in albino Wistar rats. The acute oral toxicity at a dose of 5000 mg/ kg body weight was also determined in female albino Wistar rats...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250648/the-influence-of-pluronic-f68-and-f127-nanocarrier-on-physicochemical-properties-in-vitro-release-and-antiproliferative-activity-of-thymoquinone-drug
#18
Salwa Shaarani, Shahrul Sahul Hamid, Noor Haida Mohd Kaus
BACKGROUND: This study reports on hydrophobic drug thymoquinone (TQ), an active compound found in the volatile oil of Nigella sativa that exhibits anticancer activities. Nanoformulation of this drug could potentially increase its bioavailability to specific target cells. OBJECTIVE: The aim of this study was to formulate TQ into polymer micelle, Pluronic F127 (5.0 wt %) and Pluronic F68 (0.1 wt %), as a drug carrier to enhance its solubility and instability in aqueous media...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250647/methanol-extract-of-adansonia-digitata-leaf-protects-against-sodium-arsenite-induced-toxicities-in-male-wistar-rats
#19
Ayodeji Mathias Adegoke, Michael Adedapo Gbadegesin, Oyeronke Adunni Odunola
BACKGROUND: Human and animal population exposure to arsenic through the consumption of arsenic contaminated water is rampant in many parts of the world. Protective agents of medicinal plants origin could provide maximum protection against toxicities of various kinds. OBJECTIVE: The protective role of orally administered methanol extract of the leaves of Adansonia digitata (MELAD) on sodium arsenite (SA) - induced clastogenicity and hepatotoxicity in male Wistar rats was evaluated...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28250646/antihyperglycemic-activity-of-the-leaves-from-annona-cherimola-miller-and-rutin-on-alloxan-induced-diabetic-rats
#20
Fernando Calzada, Jesús Iván Solares-Pascasio, R M Ordoñez-Razo, Claudia Velazquez, Elizabeth Barbosa, Normand García-Hernández, David Mendez-Luna, José Correa-Basurto
BACKGROUND: Annona cherimola, known as "chirimoya" has been reported in Mexican traditional medicine for the treatment of diabetes. OBJECTIVE: The aims of the present study were to validate and assess the traditional use of A. cherimola as an antidiabetic agent. MATERIALS AND METHODS: The ethanol extract from A. cherimola (300 mg/kg, EEAc), subsequent fractions (100 mg/kg), and rutin (30 mg/kg) were studied on alloxan-induced type 2 diabetic (AITD) and normoglycemic rats...
January 2017: Pharmacognosy Research
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