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Practical Radiation Oncology

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https://www.readbyqxmd.com/read/28089525/radiotherapeutic-management-of-vestibular-schwannomas-using-size-and-location-adapted-fractionation-regimens-to-maximize-the-therapeutic-ratio
#1
Benjamin G Slane, Uma Goyal, Joel L Grow, Christopher Morrison, Craig R Hullet, John Gordon, Abhay Sanan, Baldassarre Stea
BACKGROUND: We evaluated and compared the radiographic and clinical outcomes of patients with vestibular schwannomas treated with single fraction stereotactic radiosurgery (SRS), 5 fractions of hypofractionated stereotactic radiation therapy (hSRT), or 25 to 30 fractions of conventionally fractionated stereotactic radiation therapy (cfSRT). METHODS AND MATERIALS: Fifty-six patients treated with LINAC-based SRS (median, 12.5 Gy), hSRT (25 Gy), or cfSRT (median, 54 Gy) were retrospectively reviewed...
October 28, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28089526/a-feasibility-study-of-2-mm-bolus-for-postmastectomy-radiation-therapy
#2
Lauren C Das, Daniel W Golden, Eugenia Perevalova, Anthony C Wong, Kimberly De Nardo, Christopher Stepaniak, Daniel S Joyce, Bradley P McCabe, Yasmin Hasan, Steven J Chmura, Anne McCall
PURPOSE: The purpose of this study was to prospectively evaluate the use of daily 2-mm bolus in patients undergoing postmastectomy radiation without reconstruction using optically stimulated luminescence dosimetry and weekly assessment of skin toxicity. METHODS AND MATERIALS: We prospectively collected data from the first 49 women treated with a daily 2-mm Superflab bolus during their postmastectomy radiation therapy from 2013 to 2016 at The University of Chicago Comprehensive Cancer Center at Silver Cross...
October 24, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28029605/how-should-radiation-oncologists-interpret-the-astro-evidence-based-guideline-and-astro-choosing-wisely-campaign-for-the-treatment-of-uncomplicated-bone-metastases
#3
Srinivas Raman, Ronald Chow, Peter Hoskin, Edward Chow
No abstract text is available yet for this article.
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27889538/erratum-to-roos-de-keys-rn-kirkwood-id-the-bone-scan-as-a-biological-dosimeter-front-cover-images-with-case-history-pract-radiat-oncol-2016-6-4
#4
EDITORIAL
Daniel E Roos, Robert N Keys, Ian D Kirkwood
No abstract text is available yet for this article.
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27889537/response-to-letter-to-the-editor-regarding-the-dosimetric-impact-of-image-guided-radiation-therapy-by-intratumoral-fiducial-markers
#5
LETTER
Suhong Yu, Varun Sehgal, Muthana Al-Ghazi, Lesley Lawrenson, Randy Wei, Jeffrey Kuo, Parima Daroui, Nilam Ramsinghani
No abstract text is available yet for this article.
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27742559/management-of-independent-motion-between-multiple-targets-in-lung-cancer-radiation-therapy
#6
Feng Liu, An Tai, Ergun Ahunbay, Elizabeth Gore, Candice Johnstone, X Allen Li
PURPOSE: To quantify interfractional independent motions between multiple primary targets in radiation therapy (RT) of lung cancer and to study the dosimetric benefits of an online adaptive replanning method to account for these variations. METHODS AND MATERIALS: Ninety-five on-treatment diagnostic-quality computed tomography (CT) scans acquired for 9 lung cancer patients treated with image-guided RT (IGRT) using a CT-on-rails (CTVision, Siemens) were analyzed. On each on-treatment CT set, contours of the targets (gross tumor volume, clinical target volume, or involved nodes), and organs at risk were generated by populating the planning contours using an autosegmentation tool (ABAS, Elekta) with manual editing...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27742558/development-of-3-dimensional-transperineal-ultrasound-for-image-guided-radiation-therapy-of-the-prostate-early-evaluations-of-feasibility-and-use-for-inter-and-intrafractional-prostate-localization
#7
Apoorva Trivedi, Takamura Ashikaga, Daphne Hard, Jessica Archambault, Martin Lachaine, David T Cooper, Harold James Wallace
PURPOSE: Transperineal ultrasound (TPUS) allows for continuous imaging of the prostate gland, but the accuracy of TPUS has not been rigorously studied. We determined the feasibility of prostate imaging with TPUS and subsequently compared prostate localization with TPUS and computed tomography (CT). METHODS AND MATERIALS: We completed 2 sequential evaluations of TPUS. The feasibility study included 15 men with localized prostate cancer and tested if TPUS adequately imaged the prostate...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27742557/inherent-functional-dependence-among-cochlear-dose-surrogates-for-stereotactic-radiosurgery-of-vestibular-schwannomas
#8
Lijun Ma, Steve E Braunstein, Philip V Theodosopoulos, Michael W McDermott, Penny K Sneed
PURPOSE: Various cochlear dose surrogates have been reported as associated with hearing outcome in studies of stereotactic radiosurgery (SRS) for vestibular schwannomas. In this study, we investigated whether an inherent functional relationship exists among these reported surrogates. METHODS AND MATERIALS: A cohort of 85 serial patient cases treated with single-fraction stereotactic radiosurgery from 1997 through 2013 at our institution was analyzed. For all the cases, the mean prescription dose was 12...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27720704/8-gy-single-fraction-radiation-for-bone-metastases-do-the-data-support-a-1-size-fits-all-approach
#9
EDITORIAL
Victor J Gonzalez, Krisha Howell
No abstract text is available yet for this article.
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27720702/preoperative-short-course-radiation-therapy-for-rectal-cancer-provides-excellent-disease-control-and-toxicity-results-from-a-single-us-institution
#10
Amit Roy, Pawinee Mahasittiwat, Ashley A Weiner, Steven R Hunt, Matthew G Mutch, Elisa H Birnbaum, Ira J Kodner, Thomas E Read, James W Fleshman, Jeffrey R Olsen, Robert J Myerson, Parag J Parikh
PURPOSE: Preoperative short-course radiation therapy (SCRT) has rarely been used for rectal cancer in the United States, although 2 randomized phase 3 trials demonstrate equivalence to conventional chemoradiation (CRT), and recent updates to national guidelines include this regimen as a treatment option. We sought to evaluate the efficacy and safety of preoperative SCRT followed by immediate surgery within 1 week to treat rectal cancer in the US setting. METHODS AND MATERIALS: All patients treated with preoperative SCRT (4 Gy × 5 fractions for total 20 Gy) followed by planned surgery within 1 week at our institution were retrospectively evaluated...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27720701/detailed-prospective-peer-review-in-a-community-radiation-oncology-clinic
#11
James D Mitchell, Thomas J Chesnut, David V Eastham, Carlo N Demandante, David J Hoopes
PURPOSE: In 2012, we instituted detailed prospective peer review of new cases. We present the outcomes of peer review on patient management and time required for peer review. METHODS AND MATERIALS: Peer review rounds were held 3 to 4 days weekly and required 2 physicians to review pertinent information from the electronic medical record and treatment planning system. Eight aspects were reviewed for each case: 1) workup and staging; 2) treatment intent and prescription; 3) position, immobilization, and simulation; 4) motion assessment and management; 5) target contours; 6) normal tissue contours; 7) target dosimetry; and 8) normal tissue dosimetry...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27665054/regarding-the-dosimetric-impact-of-image-guided-radiation-therapy-by-intratumoral-fiducial-markers
#12
LETTER
Jeffrey V Siebers, J James Gordon
No abstract text is available yet for this article.
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27663933/palliative-radiation-therapy-for-bone-metastases-update-of-an-astro-evidence-based-guideline
#13
Stephen Lutz, Tracy Balboni, Joshua Jones, Simon Lo, Joshua Petit, Shayna E Rich, Rebecca Wong, Carol Hahn
PURPOSE: The purpose is to provide an update the Bone Metastases Guideline published in 2011 based on evidence complemented by expert opinion. The update will discuss new high-quality literature for the 8 key questions from the original guideline and implications for practice. METHODS AND MATERIALS: A systematic PubMed search from the last date included in the original Guideline yielded 414 relevant articles. Ultimately, 20 randomized controlled trials, 32 prospective nonrandomized studies, and 4 meta-analyses/pooled analyses were selected and abstracted into evidence tables...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27663932/online-patient-information-from-radiation-oncology-departments-is-too-complex-for-the-general-population
#14
Stephen A Rosenberg, David M Francis, Craig R Hullet, Zachary S Morris, Jeffrey V Brower, Bethany M Anderson, Kristin A Bradley, Michael F Bassetti, Randall J Kimple
PURPOSE: Nearly two-thirds of cancer patients seek information about their diagnosis online. We assessed the readability of online patient education materials found on academic radiation oncology department Web sites to determine whether they adhered to guidelines suggesting that information be presented at a sixth-grade reading level. METHODS AND MATERIALS: The Association of American Medical Colleges Web site was used to identify all academic radiation oncology departments in the United States...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27663931/long-term-results-on-the-efficacy-of-argon-plasma-coagulation-for-patients-with-chronic-radiation-proctitis-after-conventionally-fractionated-dose-escalated-radiation-therapy-for-prostate-cancer
#15
Joseph Weiner, David Schwartz, Manuel Martinez, Joseph Safdieh, Ayse Aytaman, David Schreiber
PURPOSE: This study was designed to assess the efficacy and outcomes of argon plasma coagulation (APC) in the management of chronic radiation proctitis after conventionally fractionated, dose-escalated radiation therapy (≥7560 cGy). METHODS AND MATERIALS: We retrospectively reviewed the charts on all patients treated with external beam radiation therapy (minimum dose, 7560 cGy) for histologically confirmed prostate cancer at our institution from 2003 to 2011. Five hundred patients met these criteria; of these, 35 patients (7...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27663930/estimating-the-excess-lifetime-risk-of-radiation-induced-secondary-malignancy-smn-in-pediatric-patients-treated-with-craniospinal-irradiation-csi-conventional-radiation-therapy-versus-helical-intensity-modulated-radiation-therapy
#16
Jordan A Holmes, Bhishamjit S Chera, David J Brenner, Igor Shuryak, Adam K Wilson, Misty Lehman-Davis, David V Fried, Vivek Somasundaram, Jun Lian, Tim Cullip, Lawrence B Marks
PURPOSE: To quantify the risk of radiation-induced second malignancies (SMN) in pediatric patients receiving craniospinal irradiation (CSI) either with 3-dimensional conformal radiation therapy (Conv CSI) or tomotherapy helical intensity modulated radiation therapy (Tomo CSI). METHODS AND MATERIALS: A novel predictive model that accounts for short- and long-term carcinogenesis was incorporated into our institutional treatment planning system to quantify the lifetime risk of SMN in incidentally irradiated organs...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27637138/the-world-s-first-single-room-proton-therapy-facility-two-year-experience
#17
Jessika Contreras, Tianyu Zhao, Stephanie Perkins, Baozhou Sun, Sreekrishna Goddu, Sasa Mutic, Beth Bottani, Sharon Endicott, Jeff Michalski, Clifford Robinson, Christina Tsien, Jiayi Huang, Benjamin W Fischer-Valuck, Dennis Hallahan, Eric Klein, Jeffrey Bradley
PURPOSE: This is a review of our 2-year experience with the first single-gantry proton therapy (PT) system. METHODS AND MATERIALS: All patients were consented to participate on an institutional review board-approved prospective patient registry between December 2013 and December 2015. PT was delivered in a single-room facility using a synchrocyclotron with proton beam energy of 250 MeV. The dataset was interrogated for demographics, diagnosis, treatment modality, and clinical trial involvement...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27637137/early-and-multiple-psa-bounces-can-occur-following-high-dose-prostate-stereotactic-body-radiation-therapy-subset-analysis-of-a-phase-1-2-trial
#18
D Nathan Kim, Christopher Straka, L Chinsoo Cho, Yair Lotan, Jingsheng Yan, Brian Kavanagh, David Raben, Susan Cooley, Jeffrey Brindle, Xian Jin Xie, David Pistenmaa, Robert Timmerman
PURPOSE: We hypothesized that high-dose stereotactic body radiation therapy (SBRT) would lead to faster time to nadir and lower nadir values compared with conventional radiation therapy experiences. We now report prostate-specific antigen (PSA) kinetics following high-dose SBRT in patients treated with radiation alone. METHODS AND MATERIALS: Ninety-one patients were enrolled on the phase 1/2 dose escalation study of SBRT for localized prostate cancer. All patients with at least 36 months of follow-up and without hormone therapy were included in this analysis (n = 47)...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27637136/incidence-and-predictors-of-chest-wall-toxicity-after-high-dose-radiation-therapy-in-15-fractions
#19
Cameron W Swanick, Pamela K Allen, Randa Tao, Adenike M Olanrewaju, Jordan R Sutton, Steven H Lin, James Welsh, Prajnan Das, Joe Y Chang, Christopher H Crane, Daniel R Gomez
PURPOSE: Fifteen fraction treatment schedules are increasingly used to deliver high doses of radiation therapy (RT) to both lung and hepatobiliary malignancies. The purpose of our study was to examine the incidence and predictors of chest wall (CW) toxicity in patients treated with this regimen. METHODS AND MATERIALS: We evaluated 135 patients treated with RT to doses ≥52.5 Gy in 15 fractions for thoracic and hepatobiliary malignancies between January 2009 and December 2012...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27637135/factors-associated-with-increased-academic-productivity-among-us-academic-radiation-oncology-faculty
#20
Catherine Zhang, Stephen Murata, Mark Murata, Clifton David Fuller, Charles R Thomas, Mehee Choi, Emma B Holliday
OBJECTIVES: Publication productivity metrics can help evaluate academic faculty for hiring, promotion, grants, and awards; however, limited benchmarking data exist, which makes intra- and interdepartmental comparisons difficult. Therefore, we sought to evaluate the scholarly activity of physician faculty at academic radiation oncology (RO) departments and establish factors associated with increased academic productivity. METHODS AND MATERIALS: Citation database searches were performed for all physician-faculty in US residency-affiliated academic RO departments...
January 2017: Practical Radiation Oncology
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