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Practical Radiation Oncology

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https://www.readbyqxmd.com/read/28596092/stereotactic-body-radiation-therapy-for-early-stage-non-small-cell-lung-cancer-executive-summary-of-an-astro-evidence-based-guideline
#1
Gregory M M Videtic, Jessica Donington, Meredith Giuliani, John Heinzerling, Tomer Z Karas, Chris R Kelsey, Brian E Lally, Karen Latzka, Simon S Lo, Drew Moghanaki, Benjamin Movsas, Andreas Rimner, Michael Roach, George Rodrigues, Shervin M Shirvani, Charles B Simone, Robert Timmerman, Megan E Daly
PURPOSE: This guideline presents evidence-based recommendations for stereotactic body radiation therapy (SBRT) in challenging clinical scenarios in early-stage non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: The American Society for Radiation Oncology convened a task force to perform a systematic literature review on 4 key questions addressing: (1) application of SBRT to operable patients; (2) appropriate use of SBRT in tumors that are centrally located, large, multifocal, or unbiopsied; (3) individual tailoring of SBRT in "high-risk" clinical scenarios; and (4) SBRT as salvage therapy after recurrence...
June 5, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28551391/preoperative-vs-postoperative-radiation-therapy-in-localized-soft-tissue-sarcoma-nationwide-patterns-of-care-and-trends-in-utilization
#2
Stanislav Lazarev, Heather McGee, Erin Moshier, Meng Ru, Elizabeth G Demicco, Vishal Gupta
PURPOSE: The timing of perioperative radiation therapy (RT) in the treatment of soft tissue sarcoma (STS) varies among institutions. This study examines patterns of care, trends in utilization, and survival with preoperative versus postoperative RT for primary STS. METHODS AND MATERIALS: Using the National Cancer Data Base, we identified patients with stage I-III STS who underwent definitive surgery with either preoperative or postoperative RT between 2004 and 2012...
April 18, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28551390/potential-abscopal-response-to-dual-checkpoint-blockade-in-rcc-after-reirradiation-using-dose-painting-sbrt
#3
Quincey LaPlant, Carl Deselm, Natalie A Lockney, James Hsieh, Yoshiya Yamada
No abstract text is available yet for this article.
April 18, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28428019/radiation-therapy-for-oropharyngeal-squamous-cell-carcinoma-executive-summary-of-an-astro-evidence-based-clinical-practice-guideline
#4
David J Sher, David J Adelstein, Gopal K Bajaj, David M Brizel, Ezra E W Cohen, Aditya Halthore, Louis B Harrison, Charles Lu, Benjamin J Moeller, Harry Quon, James W Rocco, Erich M Sturgis, Roy B Tishler, Andy Trotti, John Waldron, Avraham Eisbruch
PURPOSE: To present evidence-based guidelines for the treatment of oropharyngeal squamous cell carcinoma (OPSCC) with definitive or adjuvant radiation therapy (RT). METHODS AND MATERIALS: The American Society for Radiation Oncology convened the OPSCC Guideline Panel to perform a systematic literature review investigating the following key questions: (1) When is it appropriate to add systemic therapy to definitive RT in the treatment of OPSCC? (2) When is it appropriate to deliver postoperative RT with and without systemic therapy following primary surgery for OPSCC? (3) When is it appropriate to use induction chemotherapy in the treatment of OPSCC? (4) What are the appropriate dose, fractionation, and volume regimens with and without systemic therapy in the treatment of OPSCC? RESULTS: Patients with stage IV and stage T3 N0-1 OPSCC treated with definitive RT should receive concurrent high-dose intermittent cisplatin...
April 17, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28501507/peering-over-the-chasm-diffusion-of-prostate-radiation-therapy-hypofractionation
#5
EDITORIAL
Mark K Buyyounouski
No abstract text is available yet for this article.
April 8, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28433523/association-of-preresidency-peer-reviewed-publications-with-radiation-oncology-resident-choice-of-academic-versus-private-practice-career
#6
Shearwood McClelland, Charles R Thomas, Lynn D Wilson, Emma B Holliday, Jerry J Jaboin
INTRODUCTION: The decision of radiation oncology residents to pursue academic versus private practice careers plays a central role in shaping the present and future of the field, but factors that are potentially predictive of this decision are lacking. This study was performed to examine the role of several factors publicly available before residency on postresidency career choice, including preresidency peer-reviewed publications (PRPs), which have been associated with resident career choice in comparably competitive subspecialties such as neurosurgery...
April 5, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28477798/hippocampal-sparing-and-target-volume-coverage-in-treating-3-to-10-brain-metastases-a-comparison-of-gamma-knife-single-isocenter-vmat-cyberknife-and-tomotherapy-stereotactic-radiosurgery
#7
Isabella Zhang, Jeff Antone, Jenny Li, Shyamali Saha, Adam C Riegel, Lili Vijeh, Joe Lauritano, Mihaela Marrero, Sussan Salas, Michael Schulder, Heather Zinkin, Anuj Goenka, Jonathan Knisely
PURPOSE: Our purpose was to evaluate hippocampal doses and target volume coverage with and without hippocampal sparing when treating multiple brain metastases using various stereotactic radiosurgery (SRS) platforms. METHODS AND MATERIALS: We selected 10 consecutive patients with 14 separate treatments who had been treated in our department for 3 to 10 brain metastases and added hippocampal avoidance contours. All 14 treatments were planned with GammaPlan for Gamma Knife, Eclipse for single isocenter volumetric modulated arc therapy (VMAT), TomoTherapy Treatment Planning System (TPS) for TomoTherapy, and MultiPlan for CyberKnife...
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28395915/local-failure-and-acute-radiodermatological-toxicity-in-patients-undergoing-radiation-therapy-with-and-without-postmastectomy-chest-wall-bolus-is-bolus-ever-necessary
#8
Stephen Abel, Paul Renz, Mark Trombetta, Michael Cowher, E Day Werts, Thomas B Julian, Rodney Wegner
PURPOSE: Postmastectomy chest wall radiation therapy has historically used bolus to increase dose at the skin surface. Despite the theoretical benefits of bolus, the clinical implications of locoregional tumor control, cosmesis, and the incidence of radiodermatitis are less well characterized. We hypothesized that treatment in the presence or absence of bolus results in equivalent chest wall recurrence rates, but its presence results in more severe acute dermatologic toxicity. METHODS AND MATERIALS: Locally advanced breast cancer patients undergoing chest wall radiation therapy were retrospectively reviewed from 2005 to 2015 (n = 106; 53 with bolus, 53 without)...
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28363492/commentary-on-accelerated-partial-breast-irradiation-consensus-statement-update-of-an-astro-evidence-based-consensus-statement
#9
LETTER
William Small, Tarita O Thomas, Michael Alvarado, Michael Baum, Max Bulsara, Roberto Diaz, Eric Donnelly, Sheldon Feldman, Stephen Grobmyer, Richard Hoefer, David Joseph, Song Kang, Christine Laronga, Andrea McKee, Barry Rosen, Jeffrey Tobias, Valery Uhl, Jayant S Vaidya, Frederik Wenz, Dennis Holmes
No abstract text is available yet for this article.
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28343896/assessment-of-hepatic-function-decline-after-stereotactic-body-radiation-therapy-for-primary-liver-cancer
#10
Diego A S Toesca, Evan C Osmundson, Rie von Eyben, Jenny L Shaffer, Albert C Koong, Daniel T Chang
PURPOSE: This study aims to determine how the albumin-bilirubin (ALBI) score compares with the Child-Pugh (CP) score for assessing liver function following stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: In total, 60 patients, 40 with hepatocellular carcinoma (HCC) and 20 with cholangiocarcinoma (CCA), were treated with SBRT. Liver function panels were obtained before and at 1, 3, 6, and 12 months after SBRT. Laboratory values were censored after locoregional recurrence, further liver-directed therapies, or liver transplant...
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28277261/building-a-palliative-radiation-oncology-program-from-bedside-to-b-e-d
#11
Mark J Stavas, Jonathan D Pagan, Sumeeta Varma, Benjamin Li, Lisa A Kachnic
A growing body of evidence supports the integration of palliative care with standard cancer treatments. In these situations, patients often experience a better quality of life, better quality of care, decreased cost, and, in some cases, improved survival with the addition of palliative care services to traditional treatment pathways. In this manuscript, we explore the integration of radiation oncology at palliative care. First, we discuss the impetus for change at Vanderbilt University and the inception of Vanderbilt's inpatient Palliative Radiation Oncology Service at Vanderbilt...
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28196607/development-of-a-model-web-based-system-to-support-a-statewide-quality-consortium-in-radiation-oncology
#12
Jean M Moran, Mary Feng, Lisa A Benedetti, Robin Marsh, Kent A Griffith, Martha M Matuszak, Michael Hess, Matthew McMullen, Jennifer H Fisher, Teamour Nurushev, Margaret Grubb, Stephen Gardner, Daniel Nielsen, Reshma Jagsi, James A Hayman, Lori J Pierce
PURPOSE: A database in which patient data are compiled allows analytic opportunities for continuous improvements in treatment quality and comparative effectiveness research. We describe the development of a novel, web-based system that supports the collection of complex radiation treatment planning information from centers that use diverse techniques, software, and hardware for radiation oncology care in a statewide quality collaborative, the Michigan Radiation Oncology Quality Consortium (MROQC)...
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28110939/data-driven-management-using-quantitative-metric-and-automatic-auditing-program-qmap-improves-consistency-of-radiation-oncology-processes
#13
Naichang Yu, Ping Xia, Anthony Mastroianni, Matthew D Kolar, Samuel T Chao, John F Greskovich, John H Suh
PURPOSE: Process consistency in planning and delivery of radiation therapy is essential to maintain patient safety and treatment quality and efficiency. Ensuring the timely completion of each critical clinical task is one aspect of process consistency. The purpose of this work is to report our experience in implementing a quantitative metric and automatic auditing program (QMAP) with a goal of improving the timely completion of critical clinical tasks. METHODS AND MATERIALS: Based on our clinical electronic medical records system, we developed a software program to automatically capture the completion timestamp of each critical clinical task while providing frequent alerts of potential delinquency...
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28094211/likelihood-of-unacceptable-normal-tissue-doses-in-breast-cancer-patients-undergoing-regional-nodal-irradiation-in-routine-clinical-practice
#14
Jose Bazan, Dominic DiCostanzo, Karla Kuhn, Lonika Majithia, Allison Quick, Nilendu Gupta, Julia White
PURPOSE: As indications for regional nodal irradiation (RNI) for breast cancer have expanded, so too has scrutiny over potential late toxicity from radiotherapy. This emphasizes the need for careful radiation treatment planning to maximize the therapeutic ratio. We sought to evaluate how often unacceptable doses (UDs) to organs at risk (OARs) occur and the associated factors for patients receiving RNI in daily practice. METHODS AND MATERIALS: Treatment records of patients who received RNI from February 2012 to May 2015 were studied...
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28094210/benefits-of-omitting-primary-site-radiation-therapy-after-transoral-robotic-surgery-only-time-will-tell
#15
LETTER
Eric Ojerholm, J Nicholas Lukens, Peter H Ahn, Geoffrey Geiger, Samuel Swisher-McClure, Jason Newman, Ara Chalian, Gregory Weinstein, Bert W O'Malley, Roger Cohen, Alexander Lin
No abstract text is available yet for this article.
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28094209/simplified-low-dose-rate-infant-total-body-irradiation
#16
Nels Knutson, Y James Rao, Sridhar Yaddanapudi, Stephanie M Perkins, H Harold Li
PURPOSE: Low-dose-rate total body irradiation (LDR TBI) in infants possesses unique challenges because of the setup limitations imposed by anesthesia. We present an LDR TBI method with an anteroposterior/posteroanterior arrangement and dose rate < 10 cGy/minute for infants (thickness <14 cm) without the use of a beam attenuator. MATERIALS AND METHODS: The delivery used a 6 MV TrueBeam linear accelerator (Varian Medical Systems, Palo Alto, CA) with adjustable meterset rates below 100 MU/minute...
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28089528/hydrogel-spacer-distribution-within-the-perirectal-space-in-patients-undergoing-radiotherapy-for-prostate-cancer-impact-of-spacer-symmetry-on-rectal-dose-reduction-and-the-clinical-consequences-of-hydrogel-infiltration-into-the-rectal-wall
#17
Benjamin W Fischer-Valuck, Anupama Chundury, Hiram Gay, Walter Bosch, Jeff Michalski
PURPOSE: Hydrogel prostate-rectum spacers, biomaterials placed between the prostate and rectum, continue to gain interest as a method to reduce or limit rectal dose during dose escalated prostate cancer radiation therapy. Because the spacer is initially injected into the perirectal space as a liquid, the final distribution can vary. The purpose of this study was to evaluate hydrogel spacer (SpaceOAR system) implantation and distribution from a recent prospective randomized control trial and correlate spacer symmetry with rectal dose reduction as well as rectal wall infiltration (RWI) to acute and late toxicity...
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28089527/mri-in-radiotherapy-for-lung-cancer-a-free-breathing-protocol-at-3t
#18
Shivani Kumar, Robba Rai, Daniel Moses, Callie Choong, Lois Holloway, Shalini Kavita Vinod, Gary Liney
Imaging plays a significant role in radiation therapy. Improvements in treatment delivery require sophisticated imaging technologies to define tumor volume accurately. Magnetic resonance imaging scans can provide morphological and functional information and are increasingly being used in imaging for radiation therapy; however, for lung cancer, most protocols are based on breath-hold imaging and noncompliance to breath-hold maneuver can lead to significant artifacts. For patients presenting for lung cancer radiation therapy, maintaining a breath hold can be impossible...
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28089526/a-feasibility-study-of-2-mm-bolus-for-postmastectomy-radiation-therapy
#19
Lauren C Das, Daniel W Golden, Eugenia Perevalova, Anthony C Wong, Kimberly De Nardo, Christopher Stepaniak, Daniel S Joyce, Bradley P McCabe, Yasmin Hasan, Steven J Chmura, Anne McCall
PURPOSE: The purpose of this study was to prospectively evaluate the use of daily 2-mm bolus in patients undergoing postmastectomy radiation without reconstruction using optically stimulated luminescence dosimetry and weekly assessment of skin toxicity. METHODS AND MATERIALS: We prospectively collected data from the first 49 women treated with a daily 2-mm Superflab bolus during their postmastectomy radiation therapy from 2013 to 2016 at The University of Chicago Comprehensive Cancer Center at Silver Cross...
May 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28089525/radiotherapeutic-management-of-vestibular-schwannomas-using-size-and-location-adapted-fractionation-regimens-to-maximize-the-therapeutic-ratio
#20
Benjamin G Slane, Uma Goyal, Joel L Grow, Christopher Morrison, Craig R Hullett, John Gordon, Abhay Sanan, Baldassarre Stea
BACKGROUND: We evaluated and compared the radiographic and clinical outcomes of patients with vestibular schwannomas treated with single fraction stereotactic radiosurgery (SRS), 5 fractions of hypofractionated stereotactic radiation therapy (hSRT), or 25 to 30 fractions of conventionally fractionated stereotactic radiation therapy (cfSRT). METHODS AND MATERIALS: Fifty-six patients treated with LINAC-based SRS (median, 12.5 Gy), hSRT (25 Gy), or cfSRT (median, 54 Gy) were retrospectively reviewed...
May 2017: Practical Radiation Oncology
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