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Practical Radiation Oncology

Daniel E Roos, Robert N Keys, Ian D Kirkwood
No abstract text is available yet for this article.
October 17, 2016: Practical Radiation Oncology
Jyoti Mayadev
No abstract text is available yet for this article.
October 17, 2016: Practical Radiation Oncology
Shiv P Srivastava, Chee-Wai Cheng, Indra J Das
PURPOSE: Small-volume structures usually found in the head and neck may be susceptible to dose-volume averaging, which has not been studied. Here, the impact of calculation grid size on dose distribution for tumor control probability (TCP) and normal tissue complication probability (NTCP) is investigated for head and neck (H&N) intensity modulated radiation therapy (IMRT). METHODS AND MATERIALS: IMRT plans were generated for H&N patients with different grid sizes (1-5 mm) to calculate dose and related TCP and NTCP...
October 11, 2016: Practical Radiation Oncology
Candace Correa, Eleanor E Harris, Maria Cristina Leonardi, Benjamin D Smith, Alphonse G Taghian, Alastair M Thompson, Julia White, Jay R Harris
PURPOSE: To update the accelerated partial breast irradiation Consensus Statement published in 2009 and provide guidance on use of intraoperative radiation therapy (IORT) for partial breast irradiation in early-stage breast cancer, based on published evidence complemented by expert opinion. METHODS AND MATERIALS: A systematic PubMed search using the same terms as the original Consensus Statement yielded 419 articles; 44 articles were selected. The authors synthesized the published evidence and, through a series of conference calls and e-mails, reached consensus regarding the recommendations...
September 17, 2016: Practical Radiation Oncology
William W Chance, Quynh-Nhu Nguyen, Reza Mehran, James W Welsh, Daniel R Gomez, Peter Balter, Ritsuko Komaki, Zhongxing Liao, Joe Y Chang
PURPOSE: We report our single-institution experience with stereotactic ablative radiotherapy (SABR) for adrenal metastasis and identify factors influencing outcomes, patterns of failure, and dosimetric thresholds for toxicity. METHODS AND MATERIALS: We identified patients with adrenal metastases treated with SABR from 2009 to 2015. Toxicity was evaluated with Common Terminology Criteria for Adverse Events v4.0. Local failures were categorized as in-field, marginal, or out-of-field...
September 13, 2016: Practical Radiation Oncology
Mekhail Anwar, Yao Yu, Christine M Glastonbury, Ivan H El-Sayed, Sue S Yom
PURPOSE: The ophthalmic nerve (cranial nerve V-1) runs in close proximity to the globe, optic nerve, chiasm, and brain. The purpose of this study was to provide contouring guidance using computed tomography (CT)-identifiable landmarks, based on an analysis of skin cancer patients with V-1 invasion. METHODS AND MATERIALS: Radiation oncology planning CT scans were analyzed for landmarks to guide V-1 target delineation from the skin surface to the trigeminal ganglion...
November 2016: Practical Radiation Oncology
Joel B Wolowelsky
No abstract text is available yet for this article.
November 2016: Practical Radiation Oncology
Abram Recht, Elizabeth A Comen, Richard E Fine, Gini F Fleming, Patricia H Hardenbergh, Alice Y Ho, Clifford A Hudis, E Shelley Hwang, Jeffrey J Kirshner, Monica Morrow, Kilian E Salerno, George W Sledge, Lawrence J Solin, Patricia A Spears, Timothy J Whelan, Mark R Somerfield, Stephen B Edge
: A joint American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology panel convened to develop a focused update of the American Society of Clinical Oncology guideline concerning use of postmastectomy radiotherapy (PMRT). METHODS: A recent systematic literature review by Cancer Care Ontario provided the primary evidentiary basis. The joint panel also reviewed targeted literature searches to identify new, potentially practice-changing data...
November 2016: Practical Radiation Oncology
Tyler M Seibert, Nathan S White, Gwe-Ya Kim, Vitali Moiseenko, Carrie R McDonald, Nikdokht Farid, Hauke Bartsch, Joshua Kuperman, Roshan Karunamuni, Deborah Marshall, Dominic Holland, Parag Sanghvi, Daniel R Simpson, Arno J Mundt, Anders M Dale, Jona A Hattangadi-Gluth
PURPOSE: Anatomic distortion is present in all magnetic resonance imaging (MRI) data because of nonlinearity of gradient fields; it measures up to several millimeters. We evaluated the potential for uncorrected MRI to lead to geometric miss of the target volume in stereotactic radiosurgery (SRS). METHODS AND MATERIALS: Twenty-eight SRS cases were studied retrospectively. MRI scans were corrected for gradient nonlinearity distortion in 3 dimensions, and gross tumor volumes (GTVs) were contoured...
November 2016: Practical Radiation Oncology
Sean L Berry, Amanda Boczkowski, Rongtao Ma, James Mechalakos, Margie Hunt
PURPOSE: We investigated the sources of variability in radiation therapy treatment plan output between planners within a single institution. METHODS AND MATERIALS: Forty treatment planners across 5 campuses of an institution created a plan on the same thoracic esophagus patient computed tomography scan and structure set. Plans were scored and ranked based on the planner's adherence to an ordered list of target dose coverage and normal tissue evaluation criteria...
November 2016: Practical Radiation Oncology
Hania A Al-Hallaq, Steven Chmura, Joseph K Salama, Kathryn A Winter, Clifford G Robinson, Thomas M Pisansky, Virginia Borges, Jessica R Lowenstein, Susan McNulty, James M Galvin, David S Followill, Robert D Timmerman, Julia R White, Ying Xiao, Martha M Matuszak
INTRODUCTION: In 2014, the NRG Oncology Group initiated the first National Cancer Institute-sponsored, phase 1 clinical trial of stereotactic body radiation therapy (SBRT) for the treatment of multiple metastases in multiple organ sites (BR001; NCT02206334). The primary endpoint is to test the safety of SBRT for the treatment of 2 to 4 multiple lesions in several anatomic sites in a multi-institutional setting. Because of the technical challenges inherent to treating multiple lesions as their spatial separation decreases, we present the technical requirements for NRG-BR001 and the rationale for their selection...
November 2016: Practical Radiation Oncology
Eileen M Harder, Henry S Park, Zhe Jay Chen, Roy H Decker
PURPOSE: Radiation pneumonitis (RP) may be severe after stereotactic body radiation therapy. Our purpose was to identify pulmonary and cardiac dosimetric parameters that predicted for post-stereotactic body radiation therapy grade ≥2 RP. METHODS AND MATERIALS: A total of 335 patients with ≥3 months' follow-up were included. Normal pulmonary volume was total lungs minus gross tumor volume. Pulmonary maximum dose, mean lung dose (MLD), and the percent of lung receiving ≥x Gy for 5 to 50 Gy in 5-Gy increments were collected...
November 2016: Practical Radiation Oncology
Wei Liu, Samir H Patel, Jiajian Jason Shen, Yanle Hu, Daniel P Harrington, Xiaoning Ding, Michele Y Halyard, Steven E Schild, William W Wong, Gary A Ezzell, Martin Bues
BACKGROUND: To compare plan robustness of volumetric modulated arc therapy (VMAT) with intensity modulated radiation therapy (IMRT) and to compare the effectiveness of 3 plan robustness quantification methods. METHODS AND MATERIALS: The VMAT and IMRT plans were created for 9 head and neck cancer patients. For each plan, 6 new perturbed dose distributions were computed using ±3 mm setup deviations along each of the 3 orientations. Worst-case analysis (WCA), dose-volume histogram (DVH) band (DVHB), and root-mean-square dose-volume histogram (RVH) were used to quantify plan robustness...
November 2016: Practical Radiation Oncology
Talha Shaikh, Thomas M Churilla, Pooja Monpara, Walter J Scott, Steven J Cohen, Joshua E Meyer
PURPOSE: There are limited data regarding clinical and treatment factors associated with radiation pneumonitis (RP) in patients receiving taxane-based trimodality therapy for esophageal cancer. The purpose of this study was to identify predictors of RP in patients undergoing trimodality therapy. METHODS AND MATERIALS: We retrospectively reviewed patients undergoing chemoradiation followed by esophagectomy between 2006 and 2011. The association between clinical and dosimetric factors with RP was assessed using χ(2) test and Mann-Whitney U test...
November 2016: Practical Radiation Oncology
Eleanor M Osborne, Ann H Klopp, Anuja Jhingran, Larissa A Meyer, Patricia J Eifel
PURPOSE: Treatment for locoregionally advanced cervical cancer has changed dramatically since 2000. In that year, delivery of radiation therapy with concurrent chemotherapy became standard, and in the early 2000s, use of intensity modulated RT (IMRT) and positron emission tomography (PET) became more prevalent. We sought to determine the impact of these changes on disease-specific survival (DSS) and treatment-related adverse effects in patients with cervical cancer with para-aortic lymph node (PAN) metastases treated with definitive extended-field radiation therapy...
September 7, 2016: Practical Radiation Oncology
Suhong Yu, Varun Sehgal, Muthana Al-Ghazi, Lesley Lawrenson, Randy Wei, Jeffrey Kuo, Parima Daroui, Nilam Ramsinghani
No abstract text is available yet for this article.
September 2, 2016: Practical Radiation Oncology
Feng Liu, An Tai, Ergun Ahunbay, Elizabeth Gore, Candice Johnstone, X Allen Li
PURPOSE: To quantify interfractional independent motions between multiple primary targets in radiation therapy (RT) of lung cancer and to study the dosimetric benefits of an online adaptive replanning method to account for these variations. METHODS AND MATERIALS: Ninety-five on-treatment diagnostic-quality computed tomography (CT) scans acquired for 9 lung cancer patients treated with image-guided RT (IGRT) using a CT-on-rails (CTVision, Siemens) were analyzed. On each on-treatment CT set, contours of the targets (gross tumor volume, clinical target volume, or involved nodes), and organs at risk were generated by populating the planning contours using an autosegmentation tool (ABAS, Elekta) with manual editing...
September 2, 2016: Practical Radiation Oncology
Apoorva Trivedi, Takamura Ashikaga, Daphne Hard, Jessica Archambault, Martin Lachaine, David T Cooper, Harold James Wallace
PURPOSE: Transperineal ultrasound (TPUS) allows for continuous imaging of the prostate gland, but the accuracy of TPUS has not been rigorously studied. We determined the feasibility of prostate imaging with TPUS and subsequently compared prostate localization with TPUS and computed tomography (CT). METHODS AND MATERIALS: We completed 2 sequential evaluations of TPUS. The feasibility study included 15 men with localized prostate cancer and tested if TPUS adequately imaged the prostate...
September 2, 2016: Practical Radiation Oncology
Jeffrey V Siebers, J James Gordon
No abstract text is available yet for this article.
September 2, 2016: Practical Radiation Oncology
Shannon E Fogh, Christopher H Pope, Seth A Rosenthal, Patrick D Conway, Peter R Hulick, Jennifer L Johnson, Tariq A Mian, Indra J Das, Ann Lazar, Nikhil G Thaker, Brian T Monzon
PURPOSE: The American College of Radiology (ACR) Radiation Oncology Practice Accreditation (ROPA) program has accredited more than 600 sites since 2006, including practices within academic, hospital-based, and freestanding settings. The purpose of this report is to evaluate and compare patterns of change in common deficiencies over time. METHODS AND MATERIALS: The ACR database was queried to analyze the common deficiencies noted by the ACR ROPA program between 2012 and 2014...
September 2016: Practical Radiation Oncology
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