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Journal of Gastrointestinal Oncology

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https://www.readbyqxmd.com/read/28890830/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-combined-with-two-stage-hepatectomy-for-multiple-and-bilobar-desmoplastic-small-round-cell-tumor-liver-metastases
#1
Alejandro Cracco, Mayank Roy, Conrad H Simpfendorfer
Desmoplastic small round cell tumor (DSRCT) is a rare mesenchymal tumor usually affecting young patients. Local dissemination is common, and liver is the most common site for extraperitoneal metastases. Multimodal management has been shown to be the most effective treatment. Some authors consider liver metastases especially bi-lobar disease as a contraindication for surgical resection. We present a case of a DSRCT with bi-lobar metastases in an adult patient who underwent multi-modal management along with hepatectomy...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890829/a-rare-case-of-primary-rectal-squamous-cell-carcinoma-diagnosed-by-endoscopic-ultrasound
#2
Amirali Kiyani, Walter J Coyle, Fei Bao
Primary squamous cell carcinoma (SCC) of the rectum is a very rare entity making up to 0.1-0.25/1,000 cases of all colorectal cancers. Here, we present the case of an otherwise healthy 63-year-old female who presented with progressive pelvic discomfort, new onset constipation and a complex mass in presacral region on imaging which was proved to be poorly differentiated SCC of the rectum. The correct diagnosis was achieved by fine needle aspiration (FNA) via endoscopic ultrasound (EUS-guided FNA) as initial conventional colonoscopy failed to establish the diagnosis...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890828/radiation-induced-gastroparesis-case-report-and-literature-review
#3
Pierre Annede, Caroline Prieux-Klotz, Thomas Dubergé, Cyrus Chargari, Olivier Gisserot, Jean-Pierre de Jaureguiberry
Radiation induced gastroparesis as well as the other autonomic nervous system radiation induced neuropathies are poorly described in the literature. A case of gastroparesis associated with phrenic and recurrent laryngeal nerves paralysis was observed in a 69-year old patient. She was already treated two times by rachis radiotherapy in a context of breast cancer with bone metastases. Anatomical and chronological correlation of lesions, concomitant nerve damage in the radiation fields and elimination of the main differential diagnoses allowed us to link this case of gastroparesis with the background of radiotherapy...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890827/primary-pancreatic-lymphoma-what-we-need-to-know
#4
REVIEW
Neda Rad, Alireza Khafaf, Amir Houshang Mohammad Alizadeh
Hodgkin's lymphoma is a group of malignant lymphoid which involve various organs including gastrointestinal tract. Stomach and small intestine are commonly involved more; however, pancreas can be primarily involved as well. The secondary involvement of pancreas caused by Hodgkin's lymphoma is more prevalent than the primarily involvement (1 .25-2.2% vs. <1%). Primary pancreatic lymphomas (PPLs) consist of 1-2% of all lymphoma outside nods. The symptoms and findings of PPL imaging can be akin to that of pancreas adenocarcinoma and differentiating them is difficult without examining the tissue sample...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890826/mutational-burden-on-circulating-cell-free-tumor-dna-testing-as-a-surrogate-marker-of-mismatch-repair-deficiency-or-microsatellite-instability-in-patients-with-colorectal-cancers
#5
Pashtoon Murtaza Kasi
No abstract text is available yet for this article.
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890825/splenectomy-is-an-independent-risk-factor-for-poorer-perioperative-outcomes-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-an-analysis-of-936-procedures
#6
Akshat Saxena, Winston Liauw, David L Morris
BACKGROUND: There is a paucity of data on the impact of splenectomy on peri-operative outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We report the largest series to date which addresses this topic. METHODS: Nine hundred and thirty six consecutive patients underwent CRS/HIPEC from 1996 to 2016 at a high-volume institution in Sydney, Australia. Of these, 418 (45%) underwent splenectomy. Peri-operative complications were graded according to the Clavien-Dindo Classification...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890824/gemcitabine-and-capecitabine-for-advanced-biliary-cancer
#7
Emmanuel Gabriel, Shipra Gandhi, Kristopher Attwood, Boris Kuvshinoff, Steven Hochwald, Renuka Iyer
BACKGROUND: Gemcitabine with capecitabine (gem-cap) is an established regimen for advanced biliary cancer (ABC) supported by our previously reported phase II trial. Here, we provide our updated experience. METHODS: Single institution, retrospective study from 2005 to 2015 of ABC treated with gem-cap. RESULTS: A total of 372 patients with ABC were identified, of whom 227 (61.0%) were treated with chemotherapy. 153 patients (67.4%) received gem-cap, of which 129 (56...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890823/does-lymphocyte-to-monocyte-ratio-before-during-or-after-definitive-chemoradiation-for-locally-advanced-pancreatic-cancer-predict-for-clinical-outcomes
#8
Irene Giacomelli, Daniele Scartoni, Homan Mohammadi, William F Regine, Michael D Chuong
BACKGROUND: Elevated pre-treatment lymphocyte (L) to monocyte (M) ratio (LMR) in peripheral blood has been suggested to correlate with improved survival in some malignancies, but data in the context of pancreatic cancer (PC) is limited. The aim of this study was to evaluate the prognostic significance of LMR before, during and after definitive chemoradiotherapy (CRT) for locally advanced pancreatic cancer (LAPC). METHODS: We retrospectively reviewed 57 patients with LAPC treated with definitive CRT at a single institution from 2005 to 2013...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890822/utilization-and-trends-in-palliative-therapy-for-stage-iv-pancreatic-adenocarcinoma-patients-a-u-s-population-based-study
#9
Audrey S Kulaylat, Katelin A Mirkin, Christopher S Hollenbeak, Joyce Wong
BACKGROUND: Pancreatic adenocarcinoma is an aggressive malignancy, with most patients diagnosed with advanced or metastatic disease. Palliative therapies comprise an important, but underutilized, aspect of care. This aim of this study was to characterize the trends, factors, and outcomes associated with utilization of palliative therapies. METHODS: Patients with stage IV pancreatic adenocarcinoma from the 2003-2011 U.S. National Cancer Database were identified and stratified by receipt of palliative therapy...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890821/feasibility-and-reproducibility-of-substituting-oral-contrast-with-water-for-duodenal-volume-delineation-in-patients-undergoing-pancreatic-stereotactic-body-radiotherapy
#10
Guangyin Wu, Vivek Verma, Matthias F Haefner, Sicong Li, Chi Lin
BACKGROUND: This is the first known report evaluating the feasibility of substituting oral contrast with water in efforts to delineate the duodenum for pancreatic stereotactic body radiotherapy (SBRT). METHODS: From January 2015 to August 2016, 13 patients were simulated after ingestion of 8 ounces of water approximately 15-20 min prior to their simulation scan. We examined the feasibility of contouring the duodenum thereafter, and measured the duodenal volume as well as its variation...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890820/a-margin-distance-analysis-of-the-impact-of-adjuvant-chemoradiation-on-survival-after-pancreatoduodenectomy-for-pancreatic-adenocarcinoma
#11
Lee M Ocuin, Jennifer L Miller-Ocuin, Mazen S Zenati, John A Vargo, Aatur D Singhi, Steven A Burton, Nathan Bahary, Melissa E Hogg, Herbert J Zeh, Amer H Zureikat
BACKGROUND: The role of adjuvant chemoradiotherapy (CRT) following pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma (PDA) remains controversial. Recent data suggest that increased margin clearance (MC: distance between tumor and cut surface) is associated with improved survival after PD, but the role of adjuvant CRT in patients with known MC is undefined. We sought to delineate the impact of adjuvant CRT on survival based on MC following PD. METHODS: Patients who underwent PD for PDA between 2002 and 2014 were retrospectively stratified into three groups based on MC: 0 mm, ≤1 mm, and >1 mm...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890819/the-role-of-induction-chemotherapy-chemoradiotherapy-in-localised-pancreatic-cancer-initial-experience-in-scotland
#12
Derek Grose, David McIntosh, Nigel Jamieson, Ross Carter, Euan Dickson, David Chang, Husam Marashi, Christina Wilson, Mohammed Alfayez, Ashleigh Kerr, Roisin O'Donoghue, Lea Haskins, Fraser Duthie, Colin J McKay, Janet Graham
BACKGROUND: Despite being relatively rare pancreatic cancer is one of the highest causes of death. Even within the potentially resectable group outcomes are poor. We present our initial experiences utilising a neoadjuvant approach to localised pancreatic cancer, evaluating survival, response rates and tolerability. METHODS: This was a retrospective analysis of a prospectively maintained database. Patients from 2012 to 2015 referred to a busy regional Hepato-Pancreatic Biliary (HPB) MDT were included...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890818/individualized-4-dimensional-computed-tomography-proton-treatment-for-pancreatic-tumors
#13
Matthew L Knecht, Ning Wang, April Vassantachart, Rachel Mifflin, Jerry D Slater, Gary Y Yang
BACKGROUND: The goal of this study is to determine whether a phase or reconstruction of a 10-phase 4 dimensional computed tomography (4D CT) scan can be used as the primary planning scan for proton treatment of the pancreas, thus eliminating the need for second a slow CT or free breathing CT. METHODS: Ten patients with pancreatic adenocarcinoma were simulated with 4D CT and a proton treatment plan generated based upon one of three primary planning scans, the T0 phase, T50 phase or average reconstruction...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890817/proton-beam-reirradiation-for-locally-recurrent-pancreatic-adenocarcinoma
#14
Pamela J Boimel, Abigail T Berman, Jonathan Li, Smith Apisarnthanarax, Stefan Both, Kristi Lelionis, Gary L Larson, Ursina Teitelbaum, John N Lukens, Edgar Ben-Josef, James M Metz, John P Plastaras
BACKGROUND: Local recurrence following definitive treatment for pancreatic adenocarcinoma is common and can be associated with significant morbidity and mortality. Retreatment options for these patients are limited. Proton beam reirradiation (PRT) may limit dose and toxicity to previously irradiated normal tissues in patients without evidence of metastatic disease. METHODS: Between 8/2010-2/2015, 15 patients with isolated, locally-recurrent pancreatic cancer were treated with PRT...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890816/epidemiological-profile-of-gastric-cancer-in-the-northwestern-region-of-algeria-about-116-cases
#15
Safia Fehim, Racheda Bouhaous, Mustapha Diaf, Amine Mokhtar Drici, Meghit Boumediene Khaled
BACKGROUND: Gastric cancer (GC) remains a public health issue despite the global incidence decrease over the last decades. GC is the third leading cause of cancer-related death worldwide and stills of poor prognosis due to its late detection. The overall objective of our study was to describe the epidemiological, clinical, and histopathological aspects of stomach cancer. However, the specific purpose was to determine the gastric precancerous lesions among patients with histologically confirmed GC admitted at the gastroenterology department of the University Hospital of Sidi-Bel-Abbes city, Algeria...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890815/the-role-of-neoadjuvant-radiotherapy-for-locally-advanced-rectal-cancer-with-resectable-synchronous-metastasis
#16
Croix C Fossum, Jasim Y Alabbad, Lindsay B Romak, Christopher L Hallemeier, Michael G Haddock, Marianne Huebner, Eric J Dozois, David W Larson
BACKGROUND: Although neoadjuvant radiotherapy is typically administered for locally-advanced rectal cancer to reduce local recurrence (LR), its role for patients who present with synchronous resectable liver and/or lung metastasis is not well defined. The aim of this study was to evaluate the role of neoadjuvant radiotherapy for patients with stage IV rectal cancer undergoing curative-intent surgery. METHODS: This study is a retrospective review of a prospectively maintained surgical registry of all consecutive adult patients who underwent curative-intent resection at Mayo Clinic in Rochester, MN, from January 1990 until December 2014 with a median follow-up time of 43 (IQR 16-67) months...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890814/outcomes-and-complications-of-radiation-therapy-in-patients-with-familial-adenomatous-polyposis
#17
Meng Gan, Dustin Boothe, Deborah W Neklason, N Jewel Samadder, Jonathan Frandsen, Megan B Keener, Shane Lloyd
BACKGROUND: The outcomes, complications, and rates of secondary malignancies from radiation therapy (RT) are not known for patients with familial adenomatous polyposis (FAP). METHODS: We queried the Hereditary Gastrointestinal Cancer Registry (HGCR) for patients with FAP who received RT. Outcomes assessed included acute and late treatment toxicity and secondary malignancies. RESULTS: We identified 15 patients undergoing 18 treatment courses...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890813/endocuff-assisted-colonoscopy-significantly-increases-sessile-serrated-adenoma-detection-in-veterans
#18
Michael D Baek, Christian S Jackson, John Lunn, Chris Nguyen, Nicole K Shah, Steve Serrao, David Juma, Richard M Strong
BACKGROUND: Colorectal cancer (CRC) is the second most common cause of cancer related deaths in the United States. Colonoscopy is the gold standard for the detection of CRC. There are many colonoscopy quality measures and among these the adenoma detection rate (ADR) has demonstrated a significant impact in reducing mortality from CRC. The primary aim of our study was to compare ADR and distribution of polyp type in patients undergoing Endocuff-assisted colonoscopy (EAC) versus standard colonoscopy (SC) in a VA system...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890812/cyclooxygenase-2-gene-polymorphisms-and-susceptibility-to-colorectal-cancer-in-a-brazilian-population
#19
Michele Tatiana Pereira Tomitão, Sergio Carlos Nahas, Marcia Saldanha Kubrusly, Tatiane Katsue Furuya, Marcio Augusto Diniz, Suely Kazue Nagahashi Marie, Adriana Vaz Safatle-Ribeiro, José Eluf-Neto, Ivan Cecconello, Ulysses Ribeiro Junior
BACKGROUND: Multi-ethnicity of Brazilian population displays high levels of genomic diversity. Polymorphism may detect people at higher risk of developing cancer, distinctive response to treatment, and prognosis. Cyclooxygenase-2 (COX-2) is induced in response to growth factors and cytokines, and is expressed in inflammatory diseases, precancerous lesions and colorectal cancer (CRC). The aim of this study was to evaluate the influence of COX-2 -1195A > G and 8473T > C polymorphisms as a risk factor of developing CRC...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890811/tumor-stage-in-patients-operated-for-rectal-cancer-a-comparison-of-the-pre-operative-mr-and-the-resection-specimen-with-specific-attention-to-the-effect-of-neo-adjuvant-radiotherapy
#20
Elmer E van Eeghen, Sandra D Bakker, Gerwin Fransen, Marcel J Flens, Ruud J L F Loffeld
BACKGROUND: Evaluate the preoperative TN stage with MR and the postoperative stage with histology. METHODS: Patients diagnosed with rectal cancer (2002-2015) and a pre-operative MR were included. A chart review was done. Pathology reports were evaluated for the post-operative tumor stage. Down staging was defined as a lower disease stage in the resection specimen compared with the pre-operative MR. Upgrading ("progression") was defined as a higher disease stage in the resection specimen...
August 2017: Journal of Gastrointestinal Oncology
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