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Journal of Gastrointestinal Oncology

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https://www.readbyqxmd.com/read/29755783/erratum-to-updated-survival-outcomes-and-analysis-of-long-term-survivors-from-the-more-study-on-safety-and-efficacy-of-radioembolization-in-patients-with-unresectable-colorectal-cancer-liver-metastases
#1
Andrew Kennedy, Michael Cohn, Douglas M Coldwell, Alain Drooz, Eduardo Ehrenwald, Adeel Kaiser, Charles W Nutting, Steven C Rose, Eric A Wang, Michael A Savin
[This corrects the article DOI: 10.21037/jgo.2017.03.10.].
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755782/folfirinox-treatment-leading-to-pathologic-complete-response-of-a-locally-advanced-pancreatic-cancer
#2
Andreas Minh Luu, Torsten Herzog, Philipp Hoehn, Anke Reinacher-Schick, Johanna Munding, Waldemar Uhl, Chris Braumann
Pancreatic cancer (PC) is a lethal disease with a poor prognosis. It is typically asymptomatic and therefore most often diagnosed at an advanced stage. A primary unresectable PC can become resectable in case of tumor regression turning palliative into neoadjuvant therapy. We present a 67-year old female patient who was diagnosed with a locally advanced adenocarcinoma of the pancreatic head. After receiving palliative intended chemotherapy with the FOLFIRINOX regimen, staging computed tomography revealed local resectability of the pancreatic head tumor...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755781/prolonged-survival-of-metastatic-hepatocellular-carcinoma-a-case-report
#3
Nadiah Zainal, Harissa Husainy Hasbullah
Management of hepatocellular carcinoma (HCC) generally follows EASL-EORTC clinical practise guideline. We report a case of a 50-year-old man who had multinodular HCC with lung metastases, whose management had deviated from the standard guideline but still survive 5 years after initial diagnosis.
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755780/appendiceal-diverticulosis-a-harbinger-of-underlying-primary-appendiceal-adenocarcinoma
#4
Jia Lin Ng, Shing Lih Wong, Ronnie Mathew
Diagnosis of primary appendiceal adenocarcinoma (PAA) is hindered by its rarity and largely asymptomatic nature. Appendiceal diverticulosis (AD) is equally rare. We report an unusual case of PAA presenting with perforated appendiceal diverticulitis, and discuss a review of the literature about its association, and its surgical and pathological implications. A middle-aged man was admitted with right iliac fossa (RIF) pain and a corresponding tender abdominal mass for 5 days. Computerised tomography (CT) scan demonstrated a thickened appendix with 3 cm abscess at its base...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755779/immune-checkpoint-inhibitors-in-gastrointestinal-malignancies
#5
REVIEW
Vishal Jindal
Gastrointestinal (GIT) tumors are extremely fatal and lethal tumors with limited therapeutic options. Antitumor immunity is new line of research in management of solid tumors. Immune check points are negative regulators of immune system and control the immune response. These checkpoints are exploited by cancer cells. Cancer cells causes early activation of checkpoints and suppress the immune response, and therefore have unchecked growth and metastasis of malignant cells. Immune checkpoint inhibitors (ICIs), downregulates these checkpoints and activate the proliferation of cytotoxic T cells which helps in lysis of tumor cells...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755778/second-line-therapy-in-advanced-upper-gastrointestinal-cancers-current-status-and-new-prospects
#6
REVIEW
Piercarlo Saletti, Alberto Zaniboni
The prognosis of patients with advanced upper gastrointestinal cancers (UGC) remains poor. Current available systemic armamentarium is limited, and little progress has been made over the last decades. Main achievements have been obtained in first-line setting, however an increasingly proportion of patients are considered for second-line therapy, although data from randomized trials are scarce or even lacking. In this comprehensive review we examine the literature to summarize the efficacy and limitations of second-line systemic options in patients with advanced UGC, with a glimpse into the innovations...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755777/management-of-locally-advanced-rectal-cancer-in-the-elderly-a-critical-review-and-algorithm
#7
REVIEW
Lara Hathout, Nell Maloney-Patel, Usha Malhotra, Shang-Jui Wang, Sita Chokhavatia, Ishita Dalal, Elizabeth Poplin, Salma K Jabbour
Colorectal cancer incidence and death rates have been declining over the past 10 years. However, it remains the second leading cause of death in men ages 60-79 and the third leading cause of death in men over 80 and in women over 60 years old. However, there is little data specific to the treatment of the elder patient, since few of these patients are included in trials. With the advent of improved therapies, there are many alternative options available. Still, no definitive consensus or guidelines have been defined for this particular patient population...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755776/gastrointestinal-stromal-tumors-in-the-imatinib-era-15-years-experience-of-a-tertiary-center
#8
Armando Peixoto, Pedro Costa-Moreira, Marco Silva, Ana Luísa Santos, Susana Lopes, Filipe Vilas-Boas, Pedro Moutinho-Ribeiro, Guilherme Macedo
Gastrointestinal stromal tumors (GISTs) were associated with a disease free survival rate of disease of 50% at 5 years, but the actual natural history since the advent of imatinib is poorly described. Our objective was to evaluate the evolution in the treatment and prognosis of patients with GISTs since the start of imatinib. Retrospective analysis of GISTs diagnosed between January 2000 and June 2015 in a Portuguese large volume center. We included 131 patients, 55% female, with a mean age of 64±14 years, followed for a median of 30 months; 64% of cases had gastric involvement; 92% of the tumors were c-Kit positive; 95% of patients were operated...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755775/rectal-and-anal-canal-neuroendocrine-tumours
#9
Teresa Raposo André, Margarida Brito, João Geraldes Freire, António Moreira
Neuroendocrine tumors (NETs) are rare, representing 0.5% of all newly diagnosed malignancies. Rectal and anal canal (AC) NETs account for less than 1% of all rectal and AC cancers. Review our institutional experience on NET of the rectum and AC, with emphasis on demographic, histological and treatment features and oncologic outcomes. The study group was identified from the Portuguese Regional South Oncological Registry. From 2000 to 2014, 22 patients with rectal or AC NETs were treated at our institution. Medical records were retrospectively reviewed...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755774/racial-ethnic-disparities-in-gallbladder-cancer-receipt-of-treatments
#10
Veeravich Jaruvongvanich, Buravej Assavapongpaiboon, Linda Wong
Background: Gallbladder cancer is a rare malignancy, yet it has a dismal prognosis. Overall survival has improved in all races/ethnicities except Hispanics and blacks. Despite improvements in gallbladder cancer management, it is not clear whether racial/ethnic disparities in stage at diagnosis and treatments exist that could potentially be the source of survival disparities. The purpose of this study was to examine race/ethnicity-specific trends in the stage of disease and receipt of treatments among adult gallbladder cancer patients in the US...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755773/early-experience-with-cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy-at-a-newly-developed-center-for-peritoneal-malignancy
#11
Whitney L Guerrero, Gitonga Munene, Paxton V Dickson, Dina Darby, Andrew M Davidoff, Michael G Martin, Evan S Glazer, David Shibata, Jeremiah L Deneve
Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has improved outcomes for patients with peritoneal carcinomatosis (PC). We present our experience from a newly developed peritoneal surface malignancy program. Methods: An IRB approved retrospective review was performed for the first 50 patients treated with CRS/HIPEC with clinicopathologic data described. Results: Patients treated with CRS/HIPEC were Caucasian (64%), female (66%) with a median age of 53 years (range, 11-73 years)...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755772/histological-and-immunohistochemical-study-of-hepatoblastoma-correlation-with-tumour-behaviour-and-survival
#12
Kala Gnanasekaran Kiruthiga, Banumathi Ramakrishna, Soumitra Saha, Sudipta Sen
Background: Hepatoblastoma (HB) has different histological subtypes, with varying prognosis. Though the survival has drastically improved, subsets of patients are not responsive to therapy. Therefore, it becomes important to determine the factors which affect the behaviour of the tumour. This study was aimed to look at the histopathological subtypes and compare with immunohistochemical (IHC) expression of CK19, beta-catenin and EpCAM and survival. Methods: This study included 55 cases of HB...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755771/preoperative-survival-calculator-for-resectable-hepatocellular-carcinoma
#13
Emmanuel Gabriel, Jin Kim, Katherine T Ostapoff, Kristopher Attwood, Sergei Kurenov, Boris Kuvshinoff, Steven N Hochwald, Steven J Nurkin
Background: Estimation of preoperative overall survival (OS) of hepatocellular carcinoma (HCC) may guide surgical decision-making. Methods: OS was analyzed using the National Cancer Data Base from 1998-2012. Patients with HCC who underwent wedge resection, lobectomy or extended lobectomy were selected. Patients who had metastatic disease or previous treatment prior to surgery were excluded. Data was randomly allocated to model building (nb =4,364) and validation cohorts (nv =1,091)...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755770/safety-and-initial-efficacy-of-radiation-segmentectomy-for-the-treatment-of-hepatic-metastases%C3%A2
#14
Craig Meiers, Amy Taylor, Brian Geller, Beau Toskich
Background: Hepatic metastatectomy and ablation are associated with prolonged survival, but not all lesions are anatomically amenable to these therapies. We evaluated safety and initial efficacy of segmental ablative transarterial radioembolization, or radiation segmentectomy (RS), as a treatment for hepatic metastases. Methods: A single institution retrospective analysis was performed of patients with hepatic metastases, determined unamenable to resection by a multidisciplinary tumor board, treated with RS from 2015-2017...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755769/an-assessment-of-candidate-genes-to-assist-prognosis-in-gastric-cancer
#15
Michael McFarlane, Julia Brettschneider, Adrian Gelsthorpe, Sean James, David Snead, Kishore Gopalakrishnan, Hisham Mehenna, Janusz Jankowski, Ramesh Arasaradnam, Chuka Nwokolo
Background: Gastric cancer (GC) is the fourth commonest cancer worldwide, with the second highest mortality rate. Its poor mortality is linked to delayed presentation. There is a drive towards non-invasive biomarker screening and monitoring of many different types of cancer, although with limited success so far. We aimed to determine if any genes from a 32-gene panel could be used to determine GC prognosis. Methods: We carried out a retrospective study on the expression of 32 genes, selected for their proven or potential links to GC, on historic formalin fixed paraffin-embedded (FFPE) GC specimens from our unit...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755768/detecting-promoter-methylation-pattern-of-apoptotic-genes-apaf1-and-caspase8-in-gastric-carcinoma-patients-undergoing-chemotherapy
#16
Fatemeh Azarkhazin, Golnaz Asaadi Tehrani
Background: DNA methylation patterns in cells dysregulation CpG island methylation of genes involved in cancer leads to increased levels of the cancer. Restoration of the apoptotic route in tumor cells of stomach in order for placing Casp8 and Apaf1 genes is a proper approach for new treatments of gastric cancer. The objective of the present study was to investigate the relationship between the pattern of methylation promoter in apoptotic genes of Casp8 and Apaf1 and gastric carcinoma in patients receiving chemotherapy...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755767/utilization-of-neoadjuvant-intensity-modulated-radiation-therapy-and-proton-beam-therapy-for-esophageal-cancer-in-the-united-states
#17
Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
Background: Randomized esophageal cancer (EC) trials have utilized two- or three-dimensional conformal radiotherapy (3DCRT). Advanced radiotherapy (RT) techniques [(ARTs): intensity-modulated radiotherapy (IMRT) and proton beam therapy (PBT)] may have benefits, but are relatively unproven. This is the first study to date evaluating utilization of ARTs versus 3DCRT in the trimodality setting in the United States. Methods: The National Cancer Data Base (NCDB) was queried (2004-2013) for newly-diagnosed cT1b-T4bN0/N+M0 EC receiving neoadjuvant CRT followed by esophagectomy...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755766/percutaneous-irreversible-electroporation-with-systemic-treatment-for-locally-advanced-pancreatic-adenocarcinoma
#18
Edward Leen, John Picard, Justin Stebbing, Mark Abel, Tony Dhillon, Harpreet Wasan
Background: The prognosis for unresectable locally advanced pancreatic adenocarcinoma (LAPC) remains poor. There is increasing interest in modern ablative techniques to improve outcomes. We report on the potential value of integrating percutaneous irreversible electroporation (IRE) in patients undergoing systemic chemotherapy. Methods: Seventy-five patients with unresectable pancreatic carcinoma underwent percutaneous IRE after chemotherapy using computerised tomography guidance under general anaesthesia...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755765/travel-distance-and-use-of-salvage-palliative-chemotherapy-in-patients-with-metastatic-colorectal-cancer
#19
Shahid Ahmed, Mahjabeen Iqbal, Duc Le, Nayyer Iqbal, Punam Pahwa
Background: Salvage palliative chemotherapy in metastatic colorectal cancer has been associated with significant improvement in survival. However, not all patients receive all available therapies. Travel burden can affect patient access and use of future therapy. The present study aims to determine relationship between travel distance (TD) and salvage palliative chemotherapy in patients with metastatic colorectal cancer. Method: A patient cohort diagnosed with metastatic colorectal cancer during 2006-2010 in the province of Saskatchewan, Canada was studied...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755764/tumor-location-impact-in-stage-ii-and-iii-colon-cancer-epidemiological-and-outcome-evaluation
#20
Nesrine Mejri, Manel Dridi, Houda El Benna, Soumaya Labidi, Nouha Daoud, Hamouda Boussen
Background: We aimed to describe clinico-pathological characteristics and differences between right-sided (RCC) and left-sided colon cancer (LCC) in Tunisian population. We also analyzed outcome to determine whether location is of prognostic significance. Methods: Clinico-pathological characteristics and Kaplan Meier survival were compared between two groups of LCC [150] and RCC [53] patients with stage II and III adenocarcinoma treated with curative intent between 2003-2014...
April 2018: Journal of Gastrointestinal Oncology
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