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Pulmonary Circulation

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https://www.readbyqxmd.com/read/30351242/express-cardiac-arrest-and-pulmonary-hypertension-in-scurvy
#1
Terry Dean, Neeru Kaushik, Sharon Williams, Matt S Zinter, Paul Kim
No abstract text is available yet for this article.
October 23, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30351241/express-ppar%C3%AE-%C3%AE-a-potential-target-in-pulmonary-hypertension-blighted-by-cancer-risk
#2
Jane A Mitchell, David Bishop-Bailey
No abstract text is available yet for this article.
October 23, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30338725/express-pulmonary-vasodilator-therapy-as-treatment-for-patients-with-a-fontan-circulation-the-emperor-s-new-clothes
#3
Floris-Jan S Ridderbos, Quint A J Hagdorn, Rolf Mf Berger
No abstract text is available yet for this article.
October 19, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30338722/express-the-impact-of-trisomy-21-on-treatment-modalities-and-outcome-in-adults-with-congenital-heart-disease-in-switzerland
#4
Judith Karen Johannes, Matthias Greutmann, Daniel Tobler, Judith Bouchardy, Dominik Stambach, Kerstin Wustmann, Fabienne Schwitz, Markus Schwerzmann
No abstract text is available yet for this article.
October 19, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30284509/express-hypoxia-induced-pulmonary-vasoconstriction-of-intra-acinar-arteries-is-impaired-in-nadph-oxidase-4-gene-deficient-mice
#5
Ghulam Murtaza, Renate Paddenberg, Uwe Pfeil, Anna Goldenberg, Petra Mermer, Wolfgang Kummer
No abstract text is available yet for this article.
October 4, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30284507/express-gremlin1-blocks-vascular-endothelial-growth-factor-signalling-in-the-pulmonary-microvascular-endothelium
#6
Simon Coyle Rowan, Lucie Piouceau, Joanna Cornwell, Lili Li, Paul McLoughlin
No abstract text is available yet for this article.
October 4, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30260738/express-treatment-with-low-dose-tacrolimus-inhibits-bleeding-complications-in-a-patient-with-hereditary-hemorrhagic-telangiectasia-and-pulmonary-arterial-hypertension
#7
Natascha Sommer, Freya Droege, Elisabetta Gamen, Urban Geisthoff, Henning Gall, Khodr Tello, Manuel Jonas Richter, Lena Deubner, Ralf Schmiedel, Matthias Hecker, Edda Frauke Spiekerkoetter, Kornelia Wirsching, Werner Seeger, Ardeschir Ghofrani, Soni Savai Pullamsetti
No abstract text is available yet for this article.
September 27, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30204062/express-case-series-of-seven-women-with-uterine-fibroids-associated-with-venous-thromboembolism-and-chronic-thromboembolic-disease
#8
Anne-Sophie Lacharite-Roberge, Farhan Raza, Riyaz Bashir, Chandra Dass, George Moser, William R Auger, Yoshiya Toyoda, Paul Forfia, Anjali Vaidya
No abstract text is available yet for this article.
September 11, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30124138/express-a-modified-risk-assessment-score-in-the-prognostic-evaluation-of-one-year-survival-rate-of-pulmonary-arterial-hypertension
#9
Wei Xiong, Mei Xu, Yunfeng Zhao, Bigyan Pudasaini, Fengfeng Han, Xuejun Guo, Jinming Liu
No abstract text is available yet for this article.
August 20, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30124135/express-cardiopulmonary-remodeling-in-fattened-beef-cattle-a-naturally-occurring-large-animal-model-of-obesity-associated-pulmonary-hypertension-with-left-heart-disease
#10
Greta M Krafsur, Joseph Neary, Franklyn Garry, Holt Timothy, Daniel Gould, Gary Mason, Milton G Thomas, Mark R Enns, Rubin Tuder, Dale Brown, Kurt R Stenmark
No abstract text is available yet for this article.
August 20, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30351175/inhaled-medical-aerosols-by-nebulizer-delivery-in-pulmonary-hypertension
#11
Heidi M Mansour
No abstract text is available yet for this article.
October 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30284508/are-anticoagulants-still-indicated-in-pulmonary-arterial-hypertension
#12
Horst Olschewski, Stuart Rich
Pulmonary arterial hypertension (PAH) is a type of pulmonary hypertension that is a progressive, fatal disease. Multiple underlying mechanisms for PAH have been identified, including vasoconstriction, intimal proliferation, medial hypertrophy, inflammation, mitochondrial dysfunction, and in situ thrombosis. Because it is an uncommon disease, it has been challenging to identify a specific treatment that targets the dominant disease mechanism in a given patient. Early success demonstrating that some patients (approximately 10%) possess pulmonary vasoreactivity at diagnosis has driven the development of pulmonary vasodilators as the mainstay of treatment...
October 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30187824/high-levels-of-healthcare-utilization-prior-to-diagnosis-in-idiopathic-pulmonary-arterial-hypertension-support-the-feasibility-of-an-early-diagnosis-algorithm-the-sphinx-project
#13
Rito Bergemann, James Allsopp, Harvey Jenner, Flora Ashley Daniels, Edmund Drage, Yevgeniy Samyshkin, Claude Schmitt, Steven Wood, David G Kiely, Allan Lawrie
Idiopathic pulmonary arterial hypertension (iPAH) is a rare progressive, life-shortening disease, usually diagnosed at an advanced stage. We hypothesize that patients with iPAH exhibit patterns of health-seeking behavior before diagnosis that will allow the development of earlier identification tools. The Sheffield Pulmonary Hypertension IndeX (SPHInX) project aims to develop a predictive algorithm based on routinely collected healthcare resource utilization (HCRU) data. This report focuses on the initial feasibility of the project, examining whether Hospital Episode Statistics (HES) data from the National Health Service in England have sufficient richness to support the development of an early diagnosis algorithm...
October 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30175690/compensated-right-ventricular-function-of-the-onset-of-pulmonary-hypertension-in-a-rat-model-depends-on-chamber-remodeling-and-contractile-augmentation
#14
Daniela Vélez-Rendón, Xiaoyan Zhang, Jesse Gerringer, Daniela Valdez-Jasso
Right-ventricular function is a good indicator of pulmonary arterial hypertension (PAH) prognosis; however, how the right ventricle (RV) adapts to the pressure overload is not well understood. Here, we aimed at characterizing the time course of RV early remodeling and discriminate the contribution of ventricular geometric remodeling and intrinsic changes in myocardial mechanical properties in a monocrotaline (MCT) animal model. In a longitudinal study of PAH, ventricular morphology and function were assessed weekly during the first four weeks after MCT exposure...
October 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30160595/sevoflurane-inhibits-cardiac-function-in-pulmonary-fibrosis-mice-through-the-tlr4-signaling-pathway
#15
Yanan Cao, Zhenghua He, Maoen Zhu, Xiaowei Gao, Yue Yang, Junjie Zhang, Yundan Pan, Qulian Guo, Yonggang Peng, E Wang
Pulmonary fibrosis is often concomitant with myocardial injury. We studied sevoflurane's effects on cardiac function and the expression of the TLR4/inducible nitric oxide synthase (iNOS) signaling pathway on a pulmonary fibrosis model. C57BL/6J wild-type (WT) and TLR4-deficient (TLR4-/- ) mice were randomly divided into a control group and a pulmonary fibrosis group. The model of pulmonary fibrosis was induced by treatment with paraquat (PQ; 20 mg/kg). Four weeks after PQ administration, mice were tested for body weight changes, and histopathology and hydroxyproline in lung...
October 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30160594/hematopoietic-stem-cell-transplantation-alters-susceptibility-to-pulmonary-hypertension-in-bmpr2-deficient-mice
#16
Alexi Crosby, Mark R Toshner, Mark R Southwood, Elaine Soon, Benjamin J Dunmore, Emily Groves, Stephen Moore, Penny Wright, Katrin Ottersbach, Cavan Bennett, Jose Guerrero, Cedric Ghevaert, Nicholas W Morrell
Increasing evidence suggests that patients with pulmonary arterial hypertension (PAH) demonstrate abnormalities in the bone marrow (BM) and hematopoietic progenitor cells. In addition, PAH is associated with myeloproliferative diseases. We have previously demonstrated that low-dose lipopolysaccharide (LPS) is a potent stimulus for the development of PAH in the context of a genetic PAH mouse model of BMPR2 dysfunction. We hypothesized that the hematopoietic progenitor cells might be driving disease in this model...
October 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30142026/clinical-and-genetic-associations-with-prostacyclin-response-in-pulmonary-arterial-hypertension
#17
Stephen J Halliday, Meng Xu, Timothy E Thayer, Jonathan D Mosley, Quanhu Sheng, Fei Ye, Eric H Farber-Eger, Meredith E Pugh, Ivan R Robbins, Tufik R Assad, James D West, Evan L Brittain, Anna R Hemnes
Parenteral prostacyclin therapy is the most efficacious pharmacologic treatment for pulmonary arterial hypertension (PAH), but clinical response is variable. We sought to identify clinical, hemodynamic, and genetic associations with response to prostacyclin therapy. We performed a retrospective analysis of patients within a de-identified electronic health record and associated DNA biobank. Patients with PAH and a right heart catheterization (RHC) in the six months before initiation of a parenteral prostacyclin were included...
October 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30142025/ultrasound-assisted-catheter-directed-thrombolysis-compared-with-anticoagulation-alone-for-treatment-of-intermediate-risk-pulmonary-embolism
#18
Andrew J Schissler, Robert J Gylnn, Piotr S Sobieszczyk, Aaron B Waxman
It is unclear if ultrasound-assisted catheter-directed thrombolysis (UACDT) confers benefit over anticoagulation (AC) alone in the management of intermediate-risk ("submassive") pulmonary embolism (PE), defined by evidence of right ventricular (RV) dysfunction in hemodynamically stable patients. This study sought to evaluate any lasting advantage of UACDT on mortality and resolution of RV dysfunction in intermediate-risk PE at a large academic medical center. Adults aged ≤ 86 years admitted with intermediate-risk PE from 2011 to 2016 were retrospectively identified...
October 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30129881/safety-and-long-term-efficacy-of-aav1-serca2a-using-nebulizer-delivery-in-a-pig-model-of-pulmonary-hypertension
#19
Shin Watanabe, Kiyotake Ishikawa, Maria Plataki, Olympia Bikou, Erik Kohlbrenner, Jaume Aguero, Lahouaria Hadri, Iratxe Zarragoikoetxea, Kenneth Fish, Jane A Leopold, Roger J Hajjar
Nebulization delivery of adeno-associated virus serotype 1 encoding sarcoplasmic reticulum Ca2+ -ATPase2a (AAV1.SERCA2a) gene was examined in a Yukatan miniature swine model of chronic pulmonary hypertension (n = 13). Nebulization of AAV1.SERCA2a resulted in homogenous distribution of vectors, lower pulmonary vascular resistance, and a trend towards better long-term survival compared to control animals.
October 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/30124140/switching-inhaled-iloprost-formulations-in-patients-with-pulmonary-arterial-hypertension-the-ventaswitch-trial
#20
Manuel J Richter, Barbara Stollfuß, Alexander Roitenberg, Frank Kleinjung, Valentin Graeff, Sabine Berghaus, Christian Müller, Hossein-Ardeschir Ghofrani
Inhaled iloprost is an effective therapy for patients with pulmonary arterial hypertension (PAH); however, some patients experience extended inhalation times when using the V10 formulation (10.0 µg/mL) to deliver a 5 -µg dose (at mouthpiece) and are at risk of incomplete inhalations and reduced inhalation frequency. VENTASWITCH was an observational, case-crossover study to evaluate inhalation behavior in patients with PAH switched from iloprost V10 to V20 (20.0 µg/mL) formulation for delivering a 5 -µg dose using the I-Neb® AAD® device...
October 2018: Pulmonary Circulation
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