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Pulmonary Circulation

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https://www.readbyqxmd.com/read/27683618/postural-tachycardia-syndrome-is-not-caused-by-deconditioning
#1
Svetlana Blitshteyn, David Fries
No abstract text is available yet for this article.
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683617/nadph-oxidase-4-is-not-involved-in-hypoxia-induced-pulmonary-hypertension
#2
C Veith, S Kraut, J Wilhelm, N Sommer, K Quanz, W Seeger, R P Brandes, N Weissmann, K Schröder
No abstract text is available yet for this article.
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683616/chronic-thromboembolic-pulmonary-hypertension-pregnancy-and-a-pulmonary-endarterectomy-a-rare-challenge
#3
Erika B Rosenzweig, Mauer Biscotti, Kirsten Cleary, Richard Smiley, Matthew D Bacchetta
It is well described that patients with group 1 forms of pulmonary arterial hypertension have a high risk of mortality during pregnancy and in the early postpartum period. However, to the authors' knowledge, the diagnosis and management of group 4 pulmonary hypertension due to chronic thromboembolic pulmonary hypertension (CTEPH) during pregnancy with early postpartum pulmonary endarterectomy (PEA) has not been previously reported. We report the case of a 28-year-old woman who received a diagnosis of CTEPH during her pregnancy, was managed as an inpatient by a multidisciplinary team throughout the pregnancy and early postpartum period, and underwent PEA 6 weeks after delivery...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683615/pregnancy-as-a-possible-trigger-for-heritable-pulmonary-arterial-hypertension
#4
Maude Limoges, David Langleben, Benjamin D Fox, Roberta Shear, Paul Wieczorek, Lawrence G Rudski, Andrew M Hirsch, Robert D Schlesinger, Lyda Lesenko
It is unclear whether pregnancy is a trigger or accelerant for idiopathic pulmonary arterial hypertension (PAH). Alternatively, its frequency close to the onset of symptoms and diagnosis in the idiopathic PAH population may represent a coincidence in a disease that predominates in young women. We describe a carrier of a BMPR2 gene mutation who had an uneventful first pregnancy but had aggressive PAH during her second pregnancy and now has ongoing heritable PAH. The possible role of pregnancy as a trigger in this vulnerable patient is discussed...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683614/sphingosine-1-phosphate-is-involved-in-the-occlusive-arteriopathy-of-pulmonary-arterial-hypertension
#5
Salina Gairhe, Sachindra R Joshi, Mrigendra M Bastola, Jared M McLendon, Masahiko Oka, Karen A Fagan, Ivan F McMurtry
Despite several advances in the pathobiology of pulmonary arterial hypertension (PAH), its pathogenesis is not completely understood. Current therapy improves symptoms but has disappointing effects on survival. Sphingosine-1-phosphate (S1P) is a lysophospholipid synthesized by sphingosine kinase 1 (SphK1) and SphK2. Considering the regulatory roles of S1P in several tissues leading to vasoconstriction, inflammation, proliferation, and fibrosis, we investigated whether S1P plays a role in the pathogenesis of PAH...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683613/cyp2c44-gene-disruption-exacerbated-pulmonary-hypertension-and-heart-failure-in-female-but-not-male-mice
#6
Sachindra Raj Joshi, Anand Lakhkar, Vidhi Dhagia, Ariadne L Zias, Vasiliki Soldatos, Kaori Oshima, Houli Jiang, Katherine Gotlinger, Jorge H Capdevila, Michal L Schwartzman, Ivan F McMurtry, Sachin A Gupte
Epoxyeicosatrienoicacids (EETs), synthesized from arachidonic acid by epoxygenases of the CYP2C and CYP2J gene subfamilies, contribute to hypoxic pulmonary vasoconstriction (HPV) in mice. Despite their roles in HPV, it is controversial whether EETs mediate or ameliorate pulmonary hypertension (PH). A recent study showed that deficiency of Cyp2j did not protect male and female mice from hypoxia-induced PH. Since CYP2C44 is a functionally important epoxygenase, we hypothesized that knockout of the Cyp2c44 gene would protect both sexes of mice from hypoxia-induced PH...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683612/versican-accumulates-in-vascular-lesions-in-pulmonary-arterial-hypertension
#7
Ya-Ting Chang, Christina K Chan, Inger Eriksson, Pamela Y Johnson, Xiaofang Cao, Christian Westöö, Christian Norvik, Annika Andersson-Sjöland, Gunilla Westergren-Thorsson, Staffan Johansson, Ulf Hedin, Lena Kjellén, Thomas N Wight, Karin Tran-Lundmark
Pulmonary arterial hypertension (PAH) is a lethal condition for which there is no effective curative pharmacotherapy. PAH is characterized by vasoconstriction, wall thickening of pulmonary arteries, and increased vascular resistance. Versican is a chondroitin sulfate proteoglycan in the vascular extracellular matrix that accumulates following vascular injury and promotes smooth-muscle cell proliferation in systemic arteries. Here, we investigated whether versican may play a similar role in PAH. Paraffin-embedded lung sections from patients who underwent lung transplantation to treat PAH were used for immunohistochemistry...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683611/an-international-physician-survey-of-pulmonary-arterial-hypertension-management
#8
Ioana R Preston, Barbara Hinzmann, Sabina Heinz, Henning Gall, David Jenkins, Nick H Kim, Irene Lang
We conducted an international study to evaluate practices in the diagnosis and management of pulmonary arterial hypertension (PAH) globally across different geographic regions. Between July and October 2012, PAH-treating physicians completed a 15-minute online questionnaire and provided patient record data for their 3 or 5 most recent patients with PAH. Overall, 560 physicians (Europe: 278; United States: 160; Argentina: 53; Japan: 69) completed the questionnaire and provided data for 2,618 patients. The proportion of physicians who described themselves as working in or affiliated with a specialized pulmonary hypertension center ranged from 13% in Argentina to 74% in the United States...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683610/an-observational-study-of-inhaled-treprostinil-respiratory-related-safety-in-patients-with-pulmonary-arterial-hypertension
#9
R T Zamanian, D J Levine, R C Bourge, S A De Souza, E B Rosenzweig, H Alnuaimat, C Burger, S C Mathai, N Leedom, K DeAngelis, A Lim, T De Marco
Inhaled treprostinil (Tyvaso) has been shown to be a safe and effective addition to pulmonary arterial hypertension (PAH) oral therapies; however, the respiratory-related safety profile of inhaled treprostinil required further elucidation in the setting of routine clinical care. The objectives of this study were to characterize respiratory-related adverse events (AEs) associated with current or recent treatment with inhaled treprostinil and to compare the incidence of respiratory-related AEs in PAH patients treated with inhaled treprostinil with that in patients treated with other Food and Drug Administration (FDA)-approved PAH therapies...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683609/assessment-of-the-physiologic-contribution-of-right-atrial-function-to-total-right-heart-function-in-patients-with-and-without-pulmonary-arterial-hypertension
#10
Joseph A Sivak, Amresh Raina, Paul R Forfia
Total right heart function requires normal function of both the right ventricle and the right atrium. However, the degree to which right atrial (RA) function and right ventricular (RV) function each contribute to total right heart function has not been quantified. In this study, we aimed to quantify the contribution of RA function to total right heart function in a group of pulmonary arterial hypertension (PAH) patients compared to a cohort of normal controls without cardiovascular disease. The normal cohort comprised 35 subjects with normal clinical echocardiograms, while the PAH cohort included 37 patients, of whom 31 had echocardiograms before and after initiation of PAH-specific therapy...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683608/hemodynamic-evidence-of-vascular-remodeling-in-combined-post-and-precapillary-pulmonary-hypertension
#11
Tufik R Assad, Evan L Brittain, Quinn S Wells, Eric H Farber-Eger, Stephen J Halliday, Laura N Doss, Meng Xu, Li Wang, Frank E Harrell, Chang Yu, Ivan M Robbins, John H Newman, Anna R Hemnes
Although commonly encountered, patients with combined postcapillary and precapillary pulmonary hypertension (Cpc-PH) have poorly understood pulmonary vascular properties. The product of pulmonary vascular resistance and compliance, resistance-compliance (RC) time, is a measure of pulmonary vascular physiology. While RC time is lower in postcapillary PH than in precapillary PH, the RC time in Cpc-PH and the effect of pulmonary wedge pressure (PWP) on RC time are unknown. We tested the hypothesis that Cpc-PH has an RC time that resembles that in pulmonary arterial hypertension (PAH) more than that in isolated postcapillary PH (Ipc-PH)...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683607/clinical-classification-in-pediatric-pulmonary-arterial-hypertension-associated-with-congenital-heart-disease
#12
Willemijn M H Zijlstra, Johannes M Douwes, Mark-Jan Ploegstra, Usha Krishnan, Marcus T R Roofthooft, Hans L Hillege, D Dunbar Ivy, Erika B Rosenzweig, Rolf M F Berger
Congenital heart disease (CHD) is a frequent cause of pediatric pulmonary arterial hypertension (PAH), with diverse etiology and outcome. We aimed to describe phenotypic heterogeneity in pediatric PAH associated with CHD (PAH-CHD), assess the applicability of the Nice CHD classification, and explore whether this classification accurately reflects patient/disease characteristics and survival. All children with CHD from a contemporary cohort of consecutive pediatric PAH patients followed in three major referral centers (Denver, New York, the Netherlands) were characterized and classified on the basis of the latest proposed clinical classification for PAH-CHD (World Symposium on Pulmonary Hypertension, Nice, 2013)...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683606/a-systematic-review-and-meta-analysis-of-trials-using-statins-in-pulmonary-arterial-hypertension
#13
Vidhu Anand, Sushil Garg, Sue Duval, Thenappan Thenappan
Statins improve pulmonary vascular remodeling and right ventricular hypertrophy in animal models of pulmonary arterial hypertension (PAH). However, clinical trials assessing the efficacy of statins in patients with PAH have reported mixed results. In this systematic review and meta-analysis, we assess the efficacy of statins in patients with PAH. We included randomized controlled clinical trials (RCTs) that evaluated the efficacy of statins in patients with PAH. Primary outcomes were mortality and change in 6-minute walk distance (6MWD)...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683605/novel-signaling-pathways-in-pulmonary-arterial-hypertension-2015-grover-conference-series
#14
REVIEW
Keytam S Awad, James D West, Vinicio de Jesus Perez, Margaret MacLean
The proliferative endothelial and smooth muscle cell phenotype, inflammation, and pulmonary vascular remodeling are prominent features of pulmonary arterial hypertension (PAH). Mutations in bone morphogenetic protein type 2 receptor (BMPR2) have been identified as the most common genetic cause of PAH and females with BMPR2 mutations are 2.5 times as likely to develop heritable forms of PAH than males. Higher levels of estrogen have also been observed in males with PAH, implicating sex hormones in PAH pathogenesis...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683604/the-emerging-role-of-epigenetics-in-pulmonary-arterial-hypertension-an-important-avenue-for-clinical-trials-2015-grover-conference-series
#15
REVIEW
Jessica H Huston, John J Ryan
Epigenetics is an emerging field of research and clinical trials in cancer therapy that also has applications for pulmonary arterial hypertension (PAH), as there is evidence that epigenetic control of gene expression plays a significant role in PAH. The three types of epigenetic modification include DNA methylation, histone modification, and RNA interference. All three have been shown to be involved in the development of PAH. Currently, the enzymes that perform these modifications are the primary targets of neoplastic therapy...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683603/role-of-oxidized-lipids-in-pulmonary-arterial-hypertension
#16
REVIEW
Salil Sharma, Grégoire Ruffenach, Soban Umar, Negar Motayagheni, Srinivasa T Reddy, Mansoureh Eghbali
Pulmonary arterial hypertension (PAH) is a multifactorial disease characterized by interplay of many cellular, molecular, and genetic events that lead to excessive proliferation of pulmonary cells, including smooth muscle and endothelial cells; inflammation; and extracellular matrix remodeling. Abnormal vascular changes and structural remodeling associated with PAH culminate in vasoconstriction and obstruction of pulmonary arteries, contributing to increased pulmonary vascular resistance, pulmonary hypertension, and right ventricular failure...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683602/integration-of-complex-data-sources-to-provide-biologic-insight-into-pulmonary-vascular-disease-2015-grover-conference-series
#17
REVIEW
Evan L Brittain, Stephen Y Chan
The application of complex data sources to pulmonary vascular diseases is an emerging and promising area of investigation. The use of -omics platforms, in silico modeling of gene networks, and linkage of large human cohorts with DNA biobanks are beginning to bear biologic insight into pulmonary hypertension. These approaches to high-throughput molecular phenotyping offer the possibility of discovering new therapeutic targets and identifying variability in response to therapy that can be leveraged to improve clinical care...
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27683601/why-we-should-care-about-the-mysteries-of-pulmonary-hypertension
#18
EDITORIAL
Horst Olschewski
No abstract text is available yet for this article.
September 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27252852/pulmonary-arterial-hypertension-in-primary-amyloidosis
#19
Meghan M Cirulis, Lyska L Emerson, David A Bull, Nathan Hatton, Jose Nativi-Nicolai, Gerhard C Hildebrandt, John J Ryan
Amyloidosis involves extravascular deposition of fibrillar proteins within tissues and organs. Primary light chain amyloidosis represents the most common form of systemic amyloidosis involving deposition of monoclonal immunoglobulin light chains. Although pulmonary amyloid deposition is common in primary amyloidosis, clinically significant pulmonary amyloidosis is uncommon, and elevated pulmonary artery pressures are rarely observed in the absence of other underlying etiologies for pulmonary hypertension, such as elevated filling pressures secondary to cardiac amyloid...
June 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27252851/pulmonary-artery-denervation-for-treatment-of-a-patient-with-pulmonary-hypertension-secondary-to-left-heart-disease
#20
Hang Zhang, Juan Zhang, Du-Jiang Xie, Xiaoming Jiang, Feng-Fu Zhang, Shao-Liang Chen
Pulmonary hypertension (PH) predicts poor outcome in patients with left heart disease. A 62-year-old man was referred for heart failure associated with ischemic cardiomyopathy. He received a diagnosis of combined postcapillary and precapillary PH secondary to left heart disease on the basis of hemodynamic parameters. After the pulmonary artery denervation procedure was performed, hemodynamic parameters were markedly improved, which resulted in a significant increase in functional capacity.
June 2016: Pulmonary Circulation
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