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Hematology Reports

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https://www.readbyqxmd.com/read/29721255/paroxysmal-nocturnal-hemoglobinuria-when-delay-in-diagnosis-and-long-therapy-occurs
#1
Salvatrice Mancuso, Giuseppe Sucato, Melania Carlisi, Marco Santoro, Giuseppe Tarantino, Emilio Iannitto, Mariasanta Napolitano, Sergio Siragusa
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal disorder characterized by hemolytic anemia, bone marrow failure and thrombosis, caused by a somatic mutation in PIG-A gene that results in the absence of CD55 and CD59, two important complement regulatory proteins. In this paper, a case of PNH is retrospectively examined looking for clinical and laboratory features, and the entire course of the disease from the onset of the symptoms is described, together with an adequate follow- up over a 7-years treatment period...
March 2, 2018: Hematology Reports
https://www.readbyqxmd.com/read/29721254/chromosome-positioning-in-interphase-nuclei-of-hematopoietic-stem-cell-and-myeloid-precursor
#2
Mariana Lomiento, Fabiana Mammoli, Emilia Maria Cristina Mazza, Silvio Bicciato, Sergio Ferrari
Human myelopoiesis is an intriguing biological process during which multipotent stem cells limit their differentiation potential generating precursors that evolve into terminally differentiated cells. The differentiation process is correlated with differential gene expression and changes in nuclear architecture. In interphase, chromosomes are distinct entities known as chromosome territories and they show a radial localization that could result in a constrain of inter-homologous distance. This element plays a role in genome stability and gene expression...
March 2, 2018: Hematology Reports
https://www.readbyqxmd.com/read/29721253/neurofibromatosis-type-i-and-multiple-myeloma-coexistence-a-possible-link
#3
Fabrizio Accardi, Valentina Marchica, Cristina Mancini, Elena Maredi, Costantina Racano, Laura Notarfranchi, Davide Martorana, Paola Storti, Eugenia Martella, Benedetta Dalla Palma, Luisa Craviotto, Massimo De Filippo, Antonio Percesepe, Franco Aversa, Nicola Giuliani
The association between Neurofibromatosis type I (NF1) and multiple myeloma (MM), a plasma cell, dyscrasia is very rare. Here we put to the attention of the scientific community two new cases. The first one is a patient with active MM whereas the second with smoldering MM. Both patients present typical features of NF1 but skeletal alterations were present only in the second case including dysplasia, marked scoliosis and osteoporosis. MM osteolytic lesions were absent in both patients. In addition to the clinical diagnosis of NF1, a molecular testing for NF1 gene mutations has been performed finding that patient one was heterozygous for the c...
March 2, 2018: Hematology Reports
https://www.readbyqxmd.com/read/29721252/acute-monocytic-leukemia-diagnosed-by-flow-cytometry-includes-acute-myeloid-leukemias-with-weakly-or-faintly-positive-non-specific-esterase-staining
#4
Yuriko Zushi, Miho Sasaki, Ayano Mori, Toshiharu Saitoh, Takae Goka, Yumi Aoyama, Yuta Goto, Hiroko Tsunemine, Taiichi Kodaka, Takayuki Takahashi
A diagnosis of acute monocytic leukemia (AML-M5) based on α-naphthyl butyrate esterase (α-NB) staining has some problems, because AML-M5 leukemic cells often show weak or faint positivity on α-NB staining. In these situations, some cases of AML-M5 tend to be misdiagnosed as AML-M0. Therefore, we evaluated the significance of weak or faint α-NB staining in AML-M5 diagnosed by flow cytometry (FCM). Nineteen AML cases in which leukemic cells were negative for naphthol AS-D chloroacetate esterase staining were studied...
March 2, 2018: Hematology Reports
https://www.readbyqxmd.com/read/29721251/bone-targeted-agents-in-multiple-myeloma
#5
Hiroko Nishida
Osteolytic bone disease, characterized by bone pain, increased risk of pathologic fractures, tumor-induced hypercalcemia known as skeletal-related events (SREs), is a frequent complication of patients with multiple myeloma (MM) and persists even in the absence of active disease, resulting in a major cause of morbidity and mortality. The interaction between myeloma cells and their surrounding cells in the bone marrow (BM) microenvironment promotes both myeloma cell growth and bone destruction and forms the vicious cycle of MM bone disease...
March 2, 2018: Hematology Reports
https://www.readbyqxmd.com/read/29721250/congenital-methemoglobinemia-misdiagnosed-as-polycythemia-vera-case-report-and-review-of-literature
#6
Dina Sameh Soliman, Mohamed Yassin
Methemoglobinemia is a rare overlooked differential diagnosis in patients presented with cyanosis and dyspnea unrelated to cardiopulmonary causes. Our patient is 29 year old Indian non-smoker male, his story started 6 months prior to presentation to our center when he had generalized fatigue and discoloration of hands. He presented with persistent polycythemia with elevated hemoglobin level. The patient was misdiagnosed in another center as polycythemia and treated with Imatinib. The diagnosis of PV was revisited and ruled out in view of negative JAK2, normal erythropoietin level and absence of features of panmyelosis...
March 2, 2018: Hematology Reports
https://www.readbyqxmd.com/read/29721249/extranodal-diffuse-large-b-cell-lymphomas-a-retrospective-case-series-and-review-of-the-literature
#7
Stergios Boussios, Ioannis Zerdes, Amalia Vassou, Eleni Bareta, Esmeralda Seraj, Alexandra Papoudou-Bai, Nicholas Pavlidis, Anna Batistatou, George Pentheroudakis
Non-Hodgkin lymphomas commonly show extranodal involvement (25-30%) but primary diffuse large B-cell lymphomas (DLBCL) with extranodal localization represent clinically and molecularly distinct entities. The present study involved retrospective analysis of case records of 4 patients who were diagnosed with extranodal DLBCL between 2010 and 2016 at the Medical Oncology and Hematology Departments of the Ioannina University Hospital, Greece. Median age of presentation was 69 years (range 60-77 years). There were 2 males and 2 females...
March 2, 2018: Hematology Reports
https://www.readbyqxmd.com/read/29383226/double-heterozygocity-for-hemoglobin-c-and-beta-thalassemia-dominant-a-rare-case-of-thalassemia-intermedia
#8
Alexandra Agapidou, Paul King, Cecilia Ng, Dimitris A Tsitsikas
No abstract text is available yet for this article.
December 22, 2017: Hematology Reports
https://www.readbyqxmd.com/read/29383225/a-rare-case-of-de-novo-cd5-diffuse-large-b-cell-lymphoma-in-leukemic-phase-and-positive-for-cd13
#9
Giovanni Carulli, Eugenio Mario Ciancia, Francesco Caracciolo, Paola Sammuri, Cristiana Domenichini, Maria Immacolata Ferreri, Alessia Di Vita, Virginia Ottaviano, Martina Rousseau, Mario Petrini
No abstract text is available yet for this article.
December 22, 2017: Hematology Reports
https://www.readbyqxmd.com/read/29383224/haploidentical-hematopoietic-stem-cell-transplantation-in-a-myelofibrosis-patient-with-primary-graft-failure
#10
Cristina Tecchio, Angelo Andreini, Claudio Costantini, Alberto Zamò, Donata de Sabata, Fiorenza Aprili, Roberta Galavotti, Emanuele Guardalben, Fabio Benedetti
No abstract text is available yet for this article.
December 22, 2017: Hematology Reports
https://www.readbyqxmd.com/read/29333227/dasatinib-induced-hemorrhagic-colitis-complicated-with-cytomegalovirus-infection
#11
Aya Nakaya, Yoshiko Azuma, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yukie Tsubokura, Akiko Konishi, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Tomoki Ito, Shosaku Nomura
No abstract text is available yet for this article.
December 22, 2017: Hematology Reports
https://www.readbyqxmd.com/read/29333226/expression-of-some-atp-binding-cassette-transporters-in-acute-myeloid-leukemia
#12
Antonella Maria Salvia, Flavia Cuviello, Sabrina Coluzzi, Roberta Nuccorini, Immacolata Attolico, Sara Pasquina Pascale, Faustino Bisaccia, Michele Pizzuti, Angela Ostuni
No abstract text is available yet for this article.
December 22, 2017: Hematology Reports
https://www.readbyqxmd.com/read/29333225/a-rare-cause-of-pericardial-effusion-and-ascites-poems-syndrome
#13
Bilal Katipoglu, Zeynep Katipoğlu, Ihsan Ates, Gokhan Yirgin, Burak Furkan Demir, Fatih Acehan
No abstract text is available yet for this article.
December 22, 2017: Hematology Reports
https://www.readbyqxmd.com/read/29333224/prdi-bf1-and-prdi-bf1p-isoform-expressions-correlate-with-disease-status-in-multiple-myeloma-patients
#14
Gabriele Buda, Francesca Guerrini, Sara Galimberti, Enrico Orciuolo, Simone Pacini, Elisa Mazzantini, Mario Petrini
No abstract text is available yet for this article.
December 22, 2017: Hematology Reports
https://www.readbyqxmd.com/read/29071056/therapy-related-myeloid-neoplasms-as-a-concerning-complication-in-acute-promyelocytic-leukemia
#15
EDITORIAL
María Del Carmen Vicente-Ayuso, María García-Roa, Ataúlfo González-Fernández, Ana María Álvarez-Carmona, Celina Benavente-Cuesta, Marta Mateo-Morales, Cristina Pérez-López, Ascensión Peña-Cortijo, Marta Polo Zarzuela, Laura Gutiérrez, Rafael Martínez-Martínez
No abstract text is available yet for this article.
September 26, 2017: Hematology Reports
https://www.readbyqxmd.com/read/29071055/gluteal-artery-injuries-including-pseudoaneurysm-associated-with-powered-bone-marrow-biopsies
#16
Aditi P Singh, Gopichand Pendurti, Shashi Singh, Alexander Shestopalov, Thomas Pacello, Louis J Reed
No abstract text is available yet for this article.
September 26, 2017: Hematology Reports
https://www.readbyqxmd.com/read/29071054/enterococcus-raffinosus-infection-with-atypical-hemolytic-uremic-syndrome-in-a-multiple-myeloma-patient-after-autologous-stem-cell-transplant
#17
Pankaj Mathur, Blake Hollowoa, Nupur Lala, Sharmilan Thanendrarajan, Aasiya Matin, Atul Kothari, Carolina Schinke
No abstract text is available yet for this article.
September 26, 2017: Hematology Reports
https://www.readbyqxmd.com/read/29071053/two-cases-of-angioimmunoblastic-t-cell-lymphoma-with-concomitant-positive-serology-for-acute-epstein-barr-virus-infection
#18
Davide Facchinelli, Angela Polino, Francesco Dima, Alice Parisi, Achille Ambrosetti, Dino Veneri
No abstract text is available yet for this article.
September 26, 2017: Hematology Reports
https://www.readbyqxmd.com/read/29071052/managing-acute-promyelocytic-leukemia-in-patients-belonging-to-the-jehovah-s-witness-congregation
#19
Anand P Jillella, Martha L Arellano, Leonard T Heffner, Manila Gaddh, Amelia A Langston, Hanna J Khoury, Abhishek Mangoankar, Vamsi K Kota
No abstract text is available yet for this article.
September 26, 2017: Hematology Reports
https://www.readbyqxmd.com/read/29071051/safety-and-efficacy-of-ibrutinib-in-a-patient-with-severe-renal-impairment
#20
EDITORIAL
Kalman Filanovsky, Lev Shvidel
No abstract text is available yet for this article.
September 26, 2017: Hematology Reports
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