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Diabetes & Metabolism Journal

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https://www.readbyqxmd.com/read/28029018/exenatide-versus-insulin-lispro-added-to-basal-insulin-in-a-subgroup-of-korean-patients-with-type-2-diabetes-mellitus
#1
Kun Ho Yoon, Elise Hardy, Jenny Han
BACKGROUND: The prevalence of type 2 diabetes mellitus (T2DM) and obesity is increasing in Korea. Clinical studies in patients with T2DM have shown that combining the glucagon-like peptide-1 receptor agonist exenatide twice daily with basal insulin is an effective glucose-lowering strategy. However, these studies were predominantly conducted in non-Asian populations. METHODS: We conducted a subgroup analysis of data from a multinational, 30-week, randomized, open-label trial to compare the effects of exenatide twice daily (n=10) or three times daily mealtime insulin lispro (n=13) among Korean patients with T2DM inadequately controlled (glycosylated hemoglobin [HbA1c] >7...
December 26, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28029017/serum-calcium-and-the-risk-of-incident-metabolic-syndrome-a-4-3-year-retrospective-longitudinal-study
#2
Jong Ha Baek, Sang Man Jin, Ji Cheol Bae, Jae Hwan Jee, Tae Yang Yu, Soo Kyoung Kim, Kyu Yeon Hur, Moon Kyu Lee, Jae Hyeon Kim
BACKGROUND: An association between serum calcium level and risk of metabolic syndrome (MetS) has been suggested in cross-sectional studies. This study aimed to evaluate the association between baseline serum calcium level and risk of incident MetS in a longitudinal study. METHODS: We conducted a retrospective longitudinal study of 12,706 participants without MetS who participated in a health screening program, had normal range serum calcium level at baseline (mean age, 51 years), and were followed up for 4...
December 26, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28029016/relationship-between-regional-body-fat-distribution-and-diabetes-mellitus-2008-to-2010-korean-national-health-and-nutrition-examination-surveys
#3
Soo In Choi, Dawn Chung, Jung Soo Lim, Mi Young Lee, Jang Yel Shin, Choon Hee Chung, Ji Hye Huh
BACKGROUND: The aim of this study was to investigate the association between regional body fat distribution, especially leg fat mass, and the prevalence of diabetes mellitus (DM) in adult populations. METHODS: A total of 3,181 men and 3,827 postmenopausal women aged 50 years or older were analyzed based on Korea National Health and Nutrition Examination Surveys (2008 to 2010). Body compositions including muscle mass and regional fat mass were measured using dual-energy X-ray absorptiometry...
December 21, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28029015/association-between-blood-mercury-level-and-visceral-adiposity-in-adults
#4
Jong Suk Park, Kyoung Hwa Ha, Ka He, Dae Jung Kim
BACKGROUND: Few studies have examined the association between mercury exposure and obesity. The aim of this study is to investigate the association between blood mercury concentrations and indices of obesity in adults. METHODS: A total of 200 healthy subjects, aged 30 to 64 years, who had no history of cardiovascular or malignant disease, were examined. Anthropometric and various biochemical profiles were measured. Visceral adipose tissue (VAT) was measured using dual-energy X-ray absorptiometry (DXA)...
December 21, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28029014/regulating-hypothalamus-gene-expression-in-food-intake-dietary-composition-or-calorie-density
#5
Mi Jang, So Young Park, Yong Woon Kim, Seung Pil Jung, Jong Yeon Kim
BACKGROUND: The proportion of saturated fatty acids/unsaturated fatty acids in the diet seems to act as a physiological regulation on obesity, cardiovascular diseases, and diabetes. Differently composed fatty acid diets may induce satiety of the hypothalamus in different ways. However, the direct effect of the different fatty acid diets on satiety in the hypothalamus is not clear. METHODS: Three experiments in mice were conducted to determine whether: different compositions of fatty acids affects gene mRNA expression of the hypothalamus over time; different types of fatty acids administered into the stomach directly affect gene mRNA expression of the hypothalamus; and fat composition changes in the diet affects gene mRNA expression of the hypothalamus...
December 16, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28029013/application-of-the-2013-american-college-of-cardiology-american-heart-association-cholesterol-guideline-to-the-korean-national-health-and-nutrition-examination-surveys-from-1998-to-2012
#6
Young Shin Song, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang, Kyong Soo Park, Soo Lim
BACKGROUND: The 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline for the treatment of blood cholesterol recommends statin therapy for individuals at high risk of atherosclerotic cardiovascular disease (ASCVD). The aim of this study was to investigate serial trends in the percentages of Korean adults considered eligible for statin therapy according to the new ACC/AHA cholesterol guideline. METHODS: Data from the Korean National Health and Nutrition Examination Survey (KNHANES) I (1998, n=7,698), II (2001, n=5,654), III (2005, n=5,269), IV (2007 to 2009, n=15,727), and V (2010 to 2012, n=16,304), which used a stratified, multistage, probability sampling design, were used as representative of the entire Korean population...
December 16, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28029012/efficacy-of-moderate-intensity-statins-in-the-treatment-of-dyslipidemia-in-korean-patients-with-type-2-diabetes-mellitus
#7
Sung Hye Kong, Bo Kyung Koo, Min Kyong Moon
BACKGROUND: There has been evidences of ethnic differences in the low density lipoprotein cholesterol (LDL-C) lowering effect of statin. We aimed to evaluate the efficacy of moderate-intensity statins in the treatment of dyslipidemia among Korean patients with type 2 diabetes mellitus (T2DM). METHODS: We analyzed a retrospective cohort that consisted of Korean patients with T2DM aged 40 to 75 years who had been prescribed any of the moderate-intensity statins (atorvastatin 10 or 20 mg, rosuvastatin 5 or 10 mg, pitavastatin 2 mg, or pravastatin 40 mg)...
December 16, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27990790/response-investigating-susceptibility-to-diabetes-using-features-of-the-adipose-tissue-in-response-to-in-utero-polycyclic-aromatic-hydrocarbons-exposure-diabetes-metab-j-2016-40-494-508
#8
LETTER
Worlanyo E Gato, Daniel A Hunter, Shamaya L Whitby, Christopher A Mays, Wilson Yau
No abstract text is available yet for this article.
December 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27990789/letter-investigating-susceptibility-to-diabetes-using-features-of-the-adipose-tissue-in-response-to-in-utero-polycyclic-aromatic-hydrocarbons-exposure-diabetes-metab-j-2016-40-494-508
#9
LETTER
https://www.readbyqxmd.com/read/27990788/determinants-of-the-risk-of-diabetic-kidney-disease-and-diabetic-retinopathy-independent-of-glucose-exposure
#10
EDITORIAL
Bo Kyung Koo
No abstract text is available yet for this article.
December 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27990787/metabolic-surgery-for-type-2-diabetes-mellitus-experience-from-asia
#11
REVIEW
Wei Jei Lee, Lwin Aung
Type 2 diabetes mellitus (T2DM) is a current global health priority and Asia is the epicenter of this epidemic disease. Unlike in the west, where older population is most affected, the burden of diabetes in Asian countries is disproportionately high in young to middle-age adults. The incidence of diabetic nephropathy is alarmingly high in patients with early onset T2DM, especially in those with poor glycemic control. How to control this chronic and debilitating disease is currently a very important health issue in Asia...
December 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766795/reduction-of-sulfonylurea-with-the-initiation-of-basal-insulin-in-patients-with-inadequately-controlled-type-2-diabetes-mellitus-undergoing-long-term-sulfonylurea-based-treatment
#12
Yeoree Yang, Jeong Ah Shin, Hae Kyung Yang, Seung Hwan Lee, Seung Hyun Ko, Yu Bae Ahn, Kun Ho Yoon, Jae Hyoung Cho
BACKGROUND: There were a limited number of studies about β-cell function after insulin initiation in patients exposed to long durations of sulfonylurea treatment. In this study, we aimed to evaluate the recovery of β-cell function and the efficacy of concurrent sulfonylurea use after the start of long-acting insulin. METHODS: In this randomized controlled study, patients with type 2 diabetes mellitus (T2DM), receiving sulfonylurea for at least 2 years with glycosylated hemoglobin (HbA1c) >7%, were randomly assigned to two groups: sulfonylurea maintenance (SM) and sulfonylurea reduction (SR)...
December 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766794/risk-factors-and-adverse-outcomes-of-severe-hypoglycemia-in-type-2-diabetes-mellitus
#13
REVIEW
Jae Seung Yun, Seung Hyun Ko
Hypoglycemia has been considered as a major barrier to achieving the proper glycemic target in type 2 diabetes mellitus patients. In particular, severe hypoglycemia (SH), which is defined as a hypoglycemic episode requiring the assistance of another person to raise the patient's glucose level, is a serious complication of diabetes because of its possible fatal outcomes. Recently, the recommendations for diabetes care have emphasized a patient-centered approach, considering the individualized patient factors including hypoglycemia...
December 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766793/clinical-course-and-risk-factors-of-diabetic-retinopathy-in-patients-with-type-2-diabetes-mellitus-in-korea
#14
Jae Seung Yun, Tae Seok Lim, Seon Ah Cha, Yu Bae Ahn, Ki Ho Song, Jin A Choi, Jinwoo Kwon, Donghyun Jee, Yang Kyung Cho, Yong Moon Park, Seung Hyun Ko
BACKGROUND: We investigated clinical course and risk factors for diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 759 patients with T2DM without DR were included from January 2001 to December 2004. Retinopathy evaluation was performed at least annually by ophthalmologists. The severity of the DR was classified into five categories according to the International Clinical Diabetic Retinopathy Severity Scales. RESULTS: Of the 759 patients, 523 patients (68...
December 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766792/baseline-corrected-qt-qtc-interval-is-associated-with-prolongation-of-qtc-during-severe-hypoglycemia-in-patients-with-type-2-diabetes-mellitus
#15
Seon Ah Cha, Jae Seung Yun, Tae Seok Lim, Yoon Goo Kang, Kang Min Lee, Ki Ho Song, Ki Dong Yoo, Yong Moon Park, Seung Hyun Ko, Yu Bae Ahn
BACKGROUND: We investigated an association between baseline heart rate-corrected QT (QTc) interval before severe hypoglycemia (SH) and prolongation of QTc interval during SH in patients with type 2 diabetes mellitus (T2DM). METHODS: Between January 2004 and June 2014, 208 patients with T2DM, who visited the emergency department because of SH and underwent standard 12-lead electrocardiography within the 6-month period before SH were consecutively enrolled. The QTc interval was analyzed during the incidence of SH, and 6 months before and after SH...
December 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766791/factors-associated-with-participation-in-diabetes-education-the-korea-national-health-and-nutrition-examination-survey-2007-to-2009
#16
Jung Min Kim, Jae Won Hong, Jung Hyun Noh, Dong Jun Kim
BACKGROUND: A recent study revealed that the participation rate in diabetes education among diabetic patients was only about 50% in Korea. We investigated the factors associated with participation in diabetes education. METHODS: The study included 1,255 patients (≥19 years old) diagnosed with diabetes drawn from the total Korea National Health and Nutrition Examination Survey 2007 to 2009 population comprising 30,705 individuals. We compared age, sex, and age- and sex-adjusted clinical characteristics in patients who had received diabetes education versus those who had not...
December 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766790/risk-factors-for-the-development-and-progression-of-diabetic-kidney-disease-in-patients-with-type-2-diabetes-mellitus-and-advanced-diabetic-retinopathy
#17
Kyung Jin Yun, Hye Ji Kim, Mee Kyoung Kim, Hyuk Sang Kwon, Ki Hyun Baek, Young Jung Roh, Ki Ho Song
BACKGROUND: Some patients with type 2 diabetes mellitus (T2DM) do not develop diabetic kidney disease (DKD) despite the presence of advanced diabetic retinopathy (DR). We aimed to investigate the presence of DKD and its risk factors in patients with T2DM and advanced DR. METHODS: We conducted a cross-sectional study in 317 patients with T2DM and advanced DR. The phenotypes of DKD were divided into three groups according to the urine albumin/creatinine ratio (uACR, mg/g) and estimated glomerular filtration rate (eGFR, mL/min/1...
December 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27535646/investigating-susceptibility-to-diabetes-using-features-of-the-adipose-tissue-in-response-to-in-utero-polycyclic-aromatic-hydrocarbons-exposure
#18
Worlanyo E Gato, Daniel A Hunter, Shamaya L Whitby, Christopher A Mays, Wilson Yau
BACKGROUND: In recent times, there has been an increase in the incidence of type 2 diabetes mellitus (T2DM) particularly in children. Adipocyte dysfunction provide a critical link between obesity and insulin resistance resulting in diabetes outcome. Further, environmental chemical exposure during early years of life might be a significant contributing factor to the increase in the incidence of T2DM. This study tests the idea that exposure to environmental contaminants (2-aminoanthracene [2AA]) in utero will show effects in the adipose tissue (AT) that signify T2DM vulnerability...
December 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766251/response-prevalence-and-risk-factors-of-gastroesophageal-reflux-disease-in-patients-with-type-2-diabetes-mellitus-diabetes-metab-j-2016-40-297-307
#19
Jun Ouk Ha, Tae Hee Lee, Chang Won Lee
No abstract text is available yet for this article.
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766250/letter-prevalence-and-risk-factors-of-gastroesophageal-reflux-disease-in-patients-with-type-2-diabetes-mellitus-diabetes-metab-j-2016-40-297-307
#20
COMMENT
Dongwon Yi
No abstract text is available yet for this article.
October 2016: Diabetes & Metabolism Journal
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