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Diabetes & Metabolism Journal

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https://www.readbyqxmd.com/read/27766795/reduction-of-sulfonylurea-with-the-initiation-of-basal-insulin-in-patients-with-inadequately-controlled-type-2-diabetes-mellitus-undergoing-long-term-sulfonylurea-based-treatment
#1
Yeoree Yang, Jeong Ah Shin, Hae Kyung Yang, Seung Hwan Lee, Seung Hyun Ko, Yu Bae Ahn, Kun Ho Yoon, Jae Hyoung Cho
BACKGROUND: There were a limited number of studies about β-cell function after insulin initiation in patients exposed to long durations of sulfonylurea treatment. In this study, we aimed to evaluate the recovery of β-cell function and the efficacy of concurrent sulfonylurea use after the start of long-acting insulin. METHODS: In this randomized controlled study, patients with type 2 diabetes mellitus (T2DM), receiving sulfonylurea for at least 2 years with glycosylated hemoglobin (HbA1c) >7%, were randomly assigned to two groups: sulfonylurea maintenance (SM) and sulfonylurea reduction (SR)...
October 11, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766794/risk-factors-and-adverse-outcomes-of-severe-hypoglycemia-in-type-2-diabetes-mellitus
#2
Jae Seung Yun, Seung Hyun Ko
Hypoglycemia has been considered as a major barrier to achieving the proper glycemic target in type 2 diabetes mellitus patients. In particular, severe hypoglycemia (SH), which is defined as a hypoglycemic episode requiring the assistance of another person to raise the patient's glucose level, is a serious complication of diabetes because of its possible fatal outcomes. Recently, the recommendations for diabetes care have emphasized a patient-centered approach, considering the individualized patient factors including hypoglycemia...
October 5, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766793/clinical-course-and-risk-factors-of-diabetic-retinopathy-in-patients-with-type-2-diabetes-mellitus-in-korea
#3
Jae Seung Yun, Tae Seok Lim, Seon Ah Cha, Yu Bae Ahn, Ki Ho Song, Jin A Choi, Jinwoo Kwon, Donghyun Jee, Yang Kyung Cho, Yong Moon Park, Seung Hyun Ko
BACKGROUND: We investigated clinical course and risk factors for diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 759 patients with T2DM without DR were included from January 2001 to December 2004. Retinopathy evaluation was performed at least annually by ophthalmologists. The severity of the DR was classified into five categories according to the International Clinical Diabetic Retinopathy Severity Scales. RESULTS: Of the 759 patients, 523 patients (68...
October 5, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766792/baseline-corrected-qt-qtc-interval-is-associated-with-prolongation-of-qtc-during-severe-hypoglycemia-in-patients-with-type-2-diabetes-mellitus
#4
Seon Ah Cha, Jae Seung Yun, Tae Seok Lim, Yoon Goo Kang, Kang Min Lee, Ki Ho Song, Ki Dong Yoo, Yong Moon Park, Seung Hyun Ko, Yu Bae Ahn
BACKGROUND: We investigated an association between baseline heart rate-corrected QT (QTc) interval before severe hypoglycemia (SH) and prolongation of QTc interval during SH in patients with type 2 diabetes mellitus (T2DM). METHODS: Between January 2004 and June 2014, 208 patients with T2DM, who visited the emergency department because of SH and underwent standard 12-lead electrocardiography within the 6-month period before SH were consecutively enrolled. The QTc interval was analyzed during the incidence of SH, and 6 months before and after SH...
October 5, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766791/factors-associated-with-participation-in-diabetes-education-the-korea-national-health-and-nutrition-examination-survey-2007-to-2009
#5
Jung Min Kim, Jae Won Hong, Jung Hyun Noh, Dong Jun Kim
BACKGROUND: A recent study revealed that the participation rate in diabetes education among diabetic patients was only about 50% in Korea. We investigated the factors associated with participation in diabetes education. METHODS: The study included 1,255 patients (≥19 years old) diagnosed with diabetes drawn from the total Korea National Health and Nutrition Examination Survey 2007 to 2009 population comprising 30,705 individuals. We compared age, sex, and age- and sex-adjusted clinical characteristics in patients who had received diabetes education versus those who had not...
September 20, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766790/risk-factors-for-the-development-and-progression-of-diabetic-kidney-disease-in-patients-with-type-2-diabetes-mellitus-and-advanced-diabetic-retinopathy
#6
Kyung Jin Yun, Hye Ji Kim, Mee Kyoung Kim, Hyuk Sang Kwon, Ki Hyun Baek, Young Jung Roh, Ki Ho Song
BACKGROUND: Some patients with type 2 diabetes mellitus (T2DM) do not develop diabetic kidney disease (DKD) despite the presence of advanced diabetic retinopathy (DR). We aimed to investigate the presence of DKD and its risk factors in patients with T2DM and advanced DR. METHODS: We conducted a cross-sectional study in 317 patients with T2DM and advanced DR. The phenotypes of DKD were divided into three groups according to the urine albumin/creatinine ratio (uACR, mg/g) and estimated glomerular filtration rate (eGFR, mL/min/1...
September 20, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766251/response-prevalence-and-risk-factors-of-gastroesophageal-reflux-disease-in-patients-with-type-2-diabetes-mellitus-diabetes-metab-j-2016-40-297-307
#7
Jun Ouk Ha, Tae Hee Lee, Chang Won Lee
No abstract text is available yet for this article.
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766250/letter-prevalence-and-risk-factors-of-gastroesophageal-reflux-disease-in-patients-with-type-2-diabetes-mellitus-diabetes-metab-j-2016-40-297-307
#8
COMMENT
Dongwon Yi
No abstract text is available yet for this article.
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766249/a-potential-issue-with-screening-prediabetes-or-diabetes-using-serum-glucose-a-delay-in-diagnosis
#9
Jun Goo Kang, Cheol-Young Park, Sung-Hee Ihm, Sung Woo Park
The aim of this study was to compare the fasting serum glucose level with the fasting plasma glucose level for diagnosing hyperglycemic states in real-life clinical situations. Additionally, we investigated a usual delay in sample processing and how such delays can impact the diagnosis of hyperglycemic states. Among 1,254 participants who had normoglycemia or impaired fasting glucose (IFG) assessed by the fasting serum glucose level, 20.9% were newly diagnosed with diabetes based on the plasma fasting glucose level...
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766247/repeated-glucose-deprivation-reperfusion-induced-pc-12-cell-death-through-the-involvement-of-foxo-transcription-factor
#10
Na Han, You Jeong Kim, Su Min Park, Seung Man Kim, Ji Suk Lee, Hye Sook Jung, Eun Ju Lee, Tae Kyoon Kim, Tae Nyun Kim, Min Jeong Kwon, Soon Hee Lee, Mi-Kyung Kim, Byoung Doo Rhee, Jeong Hyun Park
BACKGROUND: Cognitive impairment and brain damage in diabetes is suggested to be associated with hypoglycemia. The mechanisms of hypoglycemia-induced neural death and apoptosis are not clear and reperfusion injury may be involved. Recent studies show that glucose deprivation/reperfusion induced more neuronal cell death than glucose deprivation itself. The forkhead box O (FOXO) transcription factors are implicated in the regulation of cell apoptosis and survival, but their role in neuronal cells remains unclear...
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766246/effects-of-body-weight-reduction-on-serum-irisin-and-metabolic-parameters-in-obese-subjects
#11
Yaeko Fukushima, Satoshi Kurose, Hiromi Shinno, Ha Cao Thi Thu, Nana Takao, Hiromi Tsutsumi, Takaaki Hasegawa, Toshiaki Nakajima, Yutaka Kimura
BACKGROUND: Irisin is a myokine implicated in lipid and glucose metabolism. The objective of this study is to examine the effect of a body weight reduction on the serum irisin level and physical indicators in obese Japanese patients without diabetes. METHODS: The subjects were 22 patients (male/female, 5/17; age, 46.1±16.0 years; body mass index [BMI], 36.9±5.0 kg/m(2)) who completed a 6-month body weight reduction program at our clinic. The program included diet, exercise therapy and cognitive behavioral therapy...
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766243/blood-glucose-measurement-is-serum-equal-to-plasma
#12
Hye Soon Kim
No abstract text is available yet for this article.
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766242/the-effect-of-bariatric-surgery-on-diabetic-retinopathy-good-bad-or-both
#13
Dora M Gorman, Carel W le Roux, Neil G Docherty
Bariatric surgery, initially intended as a weight-loss procedure, is superior to standard lifestyle intervention and pharmacological therapy for type 2 diabetes in obese individuals. Intensive medical management of hyperglycemia is associated with improved microvascular outcomes. Whether or not the reduction in hyperglycemia observed after bariatric surgery translates to improved microvascular outcomes is yet to be determined. There is substantial heterogeneity in the data relating to the impact of bariatric surgery on diabetic retinopathy (DR), the most common microvascular complication of diabetes...
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27766241/gemigliptin-an-update-of-its-clinical-use-in-the-management-of-type-2-diabetes-mellitus
#14
REVIEW
Sung-Ho Kim, Jung-Hwa Yoo, Woo Je Lee, Cheol-Young Park
Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of oral antidiabetic agent for the treatment of type 2 diabetes mellitus. They increase endogenous levels of incretin hormones, which stimulate glucose-dependent insulin secretion, decrease glucagon secretion, and contribute to reducing postprandial hyperglycemia. Although DPP-4 inhibitors have similar benefits, they can be differentiated in terms of their chemical structure, pharmacology, efficacy and safety profiles, and clinical considerations. Gemigliptin (brand name: Zemiglo), developed by LG Life Sciences, is a potent, selective, competitive, and long acting DPP-4 inhibitor...
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27535645/rg3-improves-mitochondrial-function-and-the-expression-of-key-genes-involved-in-mitochondrial-biogenesis-in-c2c12-myotubes
#15
Min Joo Kim, Young Do Koo, Min Kim, Soo Lim, Young Joo Park, Sung Soo Chung, Hak C Jang, Kyong Soo Park
BACKGROUND: Panax ginseng has glucose-lowering effects, some of which are associated with the improvement in insulin resistance in skeletal muscle. Because mitochondria play a pivotal role in the insulin resistance of skeletal muscle, we investigated the effects of the ginsenoside Rg3, one of the active components of P. ginseng, on mitochondrial function and biogenesis in C2C12 myotubes. METHODS: C2C12 myotubes were treated with Rg3 for 24 hours. Insulin signaling pathway proteins were examined by Western blot...
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27535642/serum-25-hydroxyvitamin-d-concentration-is-independently-inversely-associated-with-insulin-resistance-in-the-healthy-non-obese-korean-population
#16
So Young Ock, Kyoung Hwa Ha, Bu Kyung Kim, Hyeon Chang Kim, Jee Seon Shim, Myung Ha Lee, Young Me Yoon, Dae Jung Kim
BACKGROUND: We evaluated the associations between 25-hydroxyvitamin D (25(OH)D) concentrations in serum and insulin resistance in the healthy Korean population. METHODS: We conducted this cross-sectional analysis in 1,807 healthy Korean people (628 men and 1,179 women) aged 30 to 64 years in the Cardiovascular and Metabolic Disease Etiologic Research Center study. All participants were assessed for 25(OH)D, fasting glucose, and insulin levels, and completed a health examination and lifestyle questionnaire according to standard procedures...
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27098507/statins-increase-mitochondrial-and-peroxisomal-fatty-acid-oxidation-in-the-liver-and-prevent-non-alcoholic-steatohepatitis-in-mice
#17
Han Sol Park, Jung Eun Jang, Myoung Seok Ko, Sung Hoon Woo, Bum Joong Kim, Hyun Sik Kim, Hye Sun Park, In Sun Park, Eun Hee Koh, Ki Up Lee
BACKGROUND: Non-alcoholic fatty liver disease is the most common form of chronic liver disease in industrialized countries. Recent studies have highlighted the association between peroxisomal dysfunction and hepatic steatosis. Peroxisomes are intracellular organelles that contribute to several crucial metabolic processes, such as facilitation of mitochondrial fatty acid oxidation (FAO) and removal of reactive oxygen species through catalase or plasmalogen synthesis. Statins are known to prevent hepatic steatosis and non-alcoholic steatohepatitis (NASH), but underlying mechanisms of this prevention are largely unknown...
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27535646/investigating-susceptibility-to-diabetes-using-features-of-the-adipose-tissue-in-response-to-in-utero-polycyclic-aromatic-hydrocarbons-exposure
#18
Worlanyo E Gato, Daniel A Hunter, Shamaya L Whitby, Christopher A Mays, Wilson Yau
BACKGROUND: In recent times, there has been an increase in the incidence of type 2 diabetes mellitus (T2DM) particularly in children. Adipocyte dysfunction provide a critical link between obesity and insulin resistance resulting in diabetes outcome. Further, environmental chemical exposure during early years of life might be a significant contributing factor to the increase in the incidence of T2DM. This study tests the idea that exposure to environmental contaminants (2-aminoanthracene [2AA]) in utero will show effects in the adipose tissue (AT) that signify T2DM vulnerability...
August 12, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27550211/response-effects-of-rebamipide-on-gastrointestinal-symptoms-in-patients-with-type-2-diabetes-mellitus-diabetes-metab-j-2016-40-240-7
#19
LETTER
Sejeong Park, So Young Park, Sang Youl Rhee
No abstract text is available yet for this article.
August 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27550210/letter-effects-of-rebamipide-on-gastrointestinal-symptoms-in-patients-with-type-2-diabetes-mellitus-diabetes-metab-j-2016-40-240-7
#20
LETTER
Jin Hwa Kim
No abstract text is available yet for this article.
August 2016: Diabetes & Metabolism Journal
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