A V Aleshkin, E O Rubalskii, N V Volozhantsev, V V Verevkin, E A Svetoch, I A Kiseleva, S S Bochkareva, O Yu Borisova, A V Popova, A G Bogun, S S Afanas'ev
Traveler's diarrhea (TD) is caused by Escherichia coli in 30% of cases. We have developed a phage cocktail for prophylaxis of TD caused by E.coli, Shigella flexneri, Shigella sonnei, Salmonella enterica, Listeria monocytogenes or Staphylococcus aureus, and investigated its effectiveness against infection caused by the non-pathogenic Lac (-) strain of E.coli K12 C600 in animal and human trials. On the 6th day of both animal and human trials E. coli K12 C600 strain was detected in titer of 10(4) CFU/g of mice feces and 10(6) CFU/g of human feces in the control (untreated) groups, while it was not detected in the samples of either of the study (phage-treated) groups...
July 2015: Bacteriophage