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Pain Management

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https://www.readbyqxmd.com/read/28434283/considering-tapentadol-as-a-first-line-analgesic-14-questions
#1
Joseph V Pergolizzi, Frank Breve, Robert Taylor, Robert B Raffa, Stephani E Strasburger, Jo Ann LeQuang
Tapentadol is the newest centrally acting analgesic to be approved by the US FDA and regulatory bodies in other countries. It has been called the first-in-class of a novel-acting analgesic mechanism of action that combines µ-opioid receptor agonist activity with neuronal norepinephrine-reuptake inhibition in a single molecule. This duality of action should combine inhibition of ascending (afferent) pain-transmitting signals with activation of descending (efferent) pain-attenuating systems (e.g., diffuse noxious inhibitory controls)...
April 24, 2017: Pain Management
https://www.readbyqxmd.com/read/28421874/pharmacokinetics-safety-and-tolerability-of-a-novel-tocopheryl-phosphate-mixture-oxycodone-transdermal-patch-system-a-phase-i-study
#2
Paul D Gavin, Lee S Simon, Thomas Schlagheck, Alisha J Smith, Sepehr Shakib
AIM: To characterize the pharmacokinetic profile and evaluate the safety and tolerability of a transdermal oxycodone patch containing tocopheryl phosphate mixture (TPM). PATIENTS & METHODS: Eleven healthy subjects received a single application of three TPM/oxycodone patches applied to the torso for 72 h. RESULTS: Oxycodone was detected 8.0 ± 2.7-h postpatch administration, reaching a mean maximum plasma concentration of 3.41 ± 1.34 ng/ml at 49...
April 19, 2017: Pain Management
https://www.readbyqxmd.com/read/28415907/transdermal-oxycodone-patch-for-the-treatment-of-postherpetic-neuralgia-a-randomized-double-blind-controlled-trial
#3
Paul D Gavin, Louise Tremper, Alisha Smith, Gemma Williams, Charles Brooker
AIM: To evaluate the efficacy, systemic exposure, safety and tolerability of a transdermal oxycodone patch containing tocopheryl phosphate mixture (TPM) in patients with postherpetic neuralgia (PHN). PATIENTS & METHODS: The study was a Phase IIa, multicenter, randomized, double-blind, vehicle-controlled crossover study. RESULTS: While the TPM/oxycodone patch did not significantly improve 'average' Numeric Pain Rating Scale scores versus vehicle patch, patients reporting high levels of paresthesia (n = 9) showed a trend toward improved pain reduction...
April 18, 2017: Pain Management
https://www.readbyqxmd.com/read/28326952/latin-american-guidelines-for-cancer-pain-management
#4
Argelia Lara-Solares, Marisol Ahumada Olea, Amparito de Los Ángeles Basantes Pinos, Sara Bistre Cohén, Patricia Bonilla Sierra, Eva Rossina Duarte Juárez, Omar A Símon Escudero, Juan Guillermo Santacruz Escudero, José Alberto Flores Cantisani
Cancer is a major public health issue. Poor pain management has devastating consequences that seriously affect quality of life, diminish functionality and place a huge emotional burden on patients and their relatives. A group of Latin American opinion leaders were invited to participate in a meeting to discuss areas associated with cancer pain. The expert panel reviewed the latest literature to draft region-specific guidelines for effective pain management. The guidelines make recommendations on tailoring treatment to the specific type of pain and provide local physicians with the state-of-the art findings in the field...
March 13, 2017: Pain Management
https://www.readbyqxmd.com/read/28326951/pain-in-children-with-intellectual-disabilities-a-randomized-controlled-trial-evaluating-caregiver-knowledge-measures
#5
Lara M Genik, Chantale A Pomerleau, C Meghan McMurtry, Lynn M Breau
Inadequate knowledge has contributed to inaccurate pain assessment and treatment for children with intellectual disabilities. AIM: Develop and evaluate pain knowledge measures and accompanying self-report ratings; determine their sensitivity to change. MATERIALS & METHODS: Young adults (n = 77; Mage = 18.89; standard deviation = 2.29; 67 females) were randomly assigned to one of two 'caring for children with intellectual disabilities' training programs (pain and visual supports)...
March 7, 2017: Pain Management
https://www.readbyqxmd.com/read/28326950/efficacy-of-the-topical-5-lidocaine-medicated-plaster-in-the-treatment-of-chronic-post-thoracotomy-neuropathic-pain
#6
Pasquale Sansone, Maria Beatrice Passavanti, Alfonso Fiorelli, Caterina Aurilio, Umberto Colella, Lorenzo De Nardis, Valerio Donatiello, Vincenzo Pota, Maria Caterina Pace
AIM: To assess the efficacy of the topical 5% lidocaine medicated plaster (Versatis(®), Grünenthal GmbH, Aachen, Germany) in patients with post-thoracotomy neuropathic pain. PATIENTS & METHODS: Patients were randomized to receive the topical 5% lidocaine medicated plaster (n = 33) or non-medicated placebo plasters (n = 30) for 12 h every day for 8 weeks. Laser-evoked potentials (LEPs) were measured, and various questionnaires/scales completed. RESULTS: Numeric Rating Scale pain scores improved significantly (p < 0...
March 3, 2017: Pain Management
https://www.readbyqxmd.com/read/28326949/the-need-for-an-ethics-framework-for-the-use-of-opioids-in-the-treatment-of-chronic-nonmalignant-pain
#7
Michael A Erdek, Peter J Pronovost
No abstract text is available yet for this article.
March 3, 2017: Pain Management
https://www.readbyqxmd.com/read/28142335/complex-regional-pain-syndrome-in-children-a-systematic-review-of-clinical-features-and-movement-disorders
#8
REVIEW
Hashem Abu-Arafeh, Ishaq Abu-Arafeh
AIM: To ascertain clinical features of complex regional pain syndrome (CRPS) in children with a focus on movement disorders. METHODS: all publications with original data on children with CRPS were assessed. Data were tabulated and descriptive statistics were applied. RESULTS: One population-based study and nine clinic-based studies provided data on demographic and clinical characteristics of childhood CRPS. Mean age of onset was 12.5 years and 85% of patients were females (risk ratio: 1...
March 2017: Pain Management
https://www.readbyqxmd.com/read/27910725/an-over-the-counter-central-sensitization-therapy-a-chronic-back-pain-registry-study-of-pain-relief-medication-use-and-their-adverse-effects
#9
Richard Staelin, Sree N Koneru, Ian M Rawe
AIM: Back pain, the most prevalent musculoskeletal chronic pain condition, is usually treated with analgesic medications of questionable efficacy and frequent occurrence of adverse side effects. OBJECTIVE: The objective was to determine the effectiveness of the ActiPatch medical devices in reducing chronic back pain, document medication related adverse side effects and establish their impact on quality of life. METHODS: Upon completing a 7-day trial, subjects were contacted via email with an assessment form using the Constant Contact email program...
March 2017: Pain Management
https://www.readbyqxmd.com/read/27901408/four-steps-to-eliminate-or-reduce-pain-in-children-caused-by-needles-part-1
#10
Stefan J Friedrichsdorf
Dr Stefan Friedrichsdorf speaks to Jade Parker, Commissioning Editor: Stefan J Friedrichsdorf, MD, is medical director of the Department of Pain Medicine, Palliative Care and Integrative Medicine at Children's Hospitals and Clinics of Minnesota, Minneapolis/St Paul, MN, USA, home to one of the largest and most comprehensive programs of its kind in the country. The interdisciplinary pain team is devoted to prevent and treat acute, procedural, neuropathic, psycho-social-spiritual, visceral, and chronic/complex pain for all inpatients and outpatients in close collaboration with all pediatric subspecialties at Children's Minnesota...
March 2017: Pain Management
https://www.readbyqxmd.com/read/27883293/psychological-mislabeling-of-chronic-pain-lessons-from-migraine-in-the-20th-century
#11
Howard B Pikoff
Starting with Freud, psychoanalytically oriented practitioners described a complex of unconscious conflicts, desires and personality traits they believed to be the primary cause of a wide range of medical disorders. This was the psychogenic model. With the advance of basic research and pharmacotherapy, the psychogenic model was gradually replaced by a biopsychobehavioral model. This model treats chronic pain as a biologically based disorder that can be influenced by psychological factors and lifestyle. The present paper argues that many patients with chronic pain may not be significantly impacted by psychological factors, and that for those who are, cognitive-behavioral therapy is the treatment of choice...
March 2017: Pain Management
https://www.readbyqxmd.com/read/27882818/comparison-of-lumbosacral-transforaminal-epidural-steroid-injection-techniques-in-terms-of-radiation-safety
#12
COMPARATIVE STUDY
Duygu Tecer, Evren Yasar, Emre Adiguzel, Mehmet Ali Taskaynatan, Birol Balaban, Arif Kenan Tan
AIM: To investigate the difference in radiation exposure to the patients between oblique and posteroanterior view, initial approach techniques in fluoroscopy-guided lumbosacral transforaminal epidural steroid injections. PATIENTS & METHODS: Total amount of Kerma area product, elapsed time of the procedure and fluoroscopy time were obtained from medical records retrospectively. RESULTS: 28 patients were included in each group. Fluoroscopy time was significantly lower in group 1, but there was no statistically significant difference in terms of procedure time and Kerma area product...
March 2017: Pain Management
https://www.readbyqxmd.com/read/27882803/parental-cardiac-response-in-the-context-of-pediatric-acute-pain-current-knowledge-and-future-directions
#13
Kaytlin Constantin, C Meghan McMurtry, Heidi N Bailey
No abstract text is available yet for this article.
March 2017: Pain Management
https://www.readbyqxmd.com/read/27866449/effect-of-magnesium-sulfate-on-morphine-activity-retention-to-control-pain-after-herniorrhaphy
#14
RANDOMIZED CONTROLLED TRIAL
Sedigheh Nadri, Hormoz Mahmoudvand, Sepideh Vahabi
AIM: This research was carried out to compare magnesium sulfate (MgSO4) with isotonic saline in terms of pain control after herniorrhaphy. PATIENTS & METHODS: A randomized double-blind study, in which the patients were blind to all. A total of 100 patients who were candidates of herniorrhaphy were randomized into two groups: experimental and control (50 patients in each). Anesthesia was induced with 20% of 4 cc of morphine. The experimental and control group received postoperative 20% of 2 cc MgSO4 in 2 cc of isotonic saline and 4 cc of isotonic saline, respectively...
March 2017: Pain Management
https://www.readbyqxmd.com/read/27809657/biofeedback-as-a-psychological-treatment-option-for-chronic-back-pain
#15
Robert Sielski, Julia Anna Glombiewski
No abstract text is available yet for this article.
March 2017: Pain Management
https://www.readbyqxmd.com/read/27776454/shedding-light-on-photo-switchable-analgesics-for-pain
#16
EDITORIAL
Parisa Gazerani
No abstract text is available yet for this article.
March 2017: Pain Management
https://www.readbyqxmd.com/read/28326948/rare-presentation-of-intrathecal-morphine-withdrawal-psychosis
#17
Rohit Aiyer, Vivek Jain, Anurag Bhatia, Boris Mekinulov, Semih Gungor
We report a case of a 57-year-old male patient with intrathecal morphine pump failure who presented with psychosis as part of a clinical presentation of opioid withdrawal. The patient was being treated for chronic back pain with an intrathecal morphine pump for several years. The patient spontaneously started to experience psychotic symptoms which included disorganized thinking, delusional thoughts, paranoia, auditory and visual hallucinations. Upon interrogation of intrathecal pump, it was found not to be functioning, thereby not delivering intrathecal morphine...
February 28, 2017: Pain Management
https://www.readbyqxmd.com/read/28166710/latin-american-guidelines-for-opioid-use-in-chronic-nononcologic-pain
#18
Argelia Lara-Solares, Carlos Aguayo Zamora, César Amescua García, João Batista Santos Garcia, María Del Rosario Berenguel Cook, Patricia Bonilla Sierra, Durval Campos Kraychete, José Alberto Flores Cantisani, Carlos Guerrero, María Del Rocío Guillén Núñez, John Jairo Hernández Castro, Andrés Hernández Ortíz, Aziza Jreige Iskandar, Osvandré Lech, Jacqueline Macías Guerra, Gerardo Ramírez Samayoa, Edwin Rangel Morillo, María Antonieta Rico Pazos, Manuel Sempértegui Gallegos
AIM: Latin-American experts in the use of opioids in patients with chronic nononcologic pain (CNOP) have updated existing recommendations to current Latin-American reality. METHODS: Several key opinion leaders from Latin America participated in a face-to-face meeting in Guatemala (April 2015) to discuss the use of opioids in CNOP. Subgroups of experts worked on specific topics, reviewed the literature and shaped the final manuscript. RESULTS: The expert panel developed guidelines taking into consideration the utility of both opioid and nonopioid analgesics and factors pertaining to their efficacy, safety, adherence, administration and risks for abuse/addiction...
February 7, 2017: Pain Management
https://www.readbyqxmd.com/read/28166700/an-industry-perspective-on-pain-treatment-in-the-uk
#19
Jan-Uwe Claas, Mark Suett
Jan-Uwe Claas and Mark Suett speak to Henry Ireland, Senior Drug Evaluations Editor: Dr Jan-Uwe Claas, General Manager, Grϋnenthal UK Ltd, and Dr Mark Suett, Interim Medical Director, discuss Grϋnenthal's role in pain management, the current barriers to improving treatment in the UK and the supporting role the company plays in advancing this field. Grünenthal UK Ltd is a subsidiary of Grünenthal GmbH, based in Aachen, Germany.
February 7, 2017: Pain Management
https://www.readbyqxmd.com/read/28152647/exercise-interventions-for-juvenile-fibromyalgia-current-state-and-recent-advancements
#20
William R Black, Susmita Kashikar-Zuck
No abstract text is available yet for this article.
February 3, 2017: Pain Management
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