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Pain Management

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https://www.readbyqxmd.com/read/29125423/management-of-chronic-neuropathic-pain-with-single-and-compounded-topical-analgesics
#1
Nebojsa Nick Knezevic, Tatiana Tverdohleb, Farid Nikibin, Ivana Knezevic, Kenneth D Candido
The goal of our review was to emphasize important aspects that physicians should take into consideration when prescribing topical analgesics as part of chronic neuropathic pain treatment. We discuss the dermatopharmacokinetics and microstructural components of the skin, differences between topical and transdermal drug delivery, and topical medication effects on peripheral neuropathy and central sensitization. Even though the US FDA approved topical analgesics are 8%-capsaicin and 5%-lidocaine patches for treating postherpetic neuralgia, there are many other studies conducted on the efficacy of topical ketamine cream, clonidine gel, topical gabapentin, topical baclofen and topical phenytoin for peripheral neuropathic pain, either alone or in combination with other formulations...
November 10, 2017: Pain Management
https://www.readbyqxmd.com/read/29125398/the-management-of-peri-and-postprocedural-pain-in-interventional-radiology-a-narrative-review
#2
Jeremy N Cashman, Lenny Ng
Interventional radiology encompasses a wide range of procedures and the degree of associated pain depends predominantly on the procedure being undertaken. Procedures may be painful during but not after the procedure, relatively painless during but painful after the procedure, or relatively painless during and after the procedure. However, there is a lack of good quality publications in interventional radiology that specifically address the subject of peri- and postprocedural pain management. Nevertheless, a variety of more or less complex protocols exist for intraprocedural sedation and for peri- and postprocedural analgesia...
November 10, 2017: Pain Management
https://www.readbyqxmd.com/read/29125396/therapies-and-mechanisms-of-opioid-withdrawal
#3
Nicole E Burma, Charlie Ht Kwok, Tuan Trang
No abstract text is available yet for this article.
November 10, 2017: Pain Management
https://www.readbyqxmd.com/read/28936907/acupuncture-for-the-management-of-cancer-related-pain
#4
Carole A Paley, Mark I Johnson
No abstract text is available yet for this article.
September 22, 2017: Pain Management
https://www.readbyqxmd.com/read/28936903/models-of-care-for-musculoskeletal-pain-conditions-driving-change-to-improve-outcomes
#5
Helen Slater, Andrew M Briggs
No abstract text is available yet for this article.
September 22, 2017: Pain Management
https://www.readbyqxmd.com/read/28937312/different-pain-responses-to-chronic-and-acute-pain-in-various-ethnic-racial-groups
#6
Behnoosh B Rahavard, Kenneth D Candido, Nebojsa Nick Knezevic
AIM: Our goal in this study was to review the similarities and differences among ethnic groups and their respective responses to acute and chronic clinically related and experimentally induced pain. METHOD: In this review, the PUBMED and Google-Scholar databases were searched to analyze articles that have assessed the variations in both acute and chronic pain responses among different ethnic/racial groups. RESULTS: According to the results from 42 reviewed articles, significant differences exist among ethnic-racial groups for pain prevalence as well as responses to acute and chronic pain...
September 2017: Pain Management
https://www.readbyqxmd.com/read/28936915/review-of-the-evidence-best-analgesic-regimen-for-shoulder-surgery
#7
Yolanda Huang, Felicia Chiu, Christopher Aj Webb, Paul David Weyker
Multimodal pain management has been advocated in patients experiencing acute pain after surgical procedures due to tissue damage and the subsequent inflammatory response. For patients undergoing shoulder surgeries, studies have definitively shown that interscalene blocks (ISBs) via single-injection or continuous infusion can reduce the total opioid consumption and can lower pain scores after surgery. In some cases, ISBs can be used as the sole anesthetic during shoulder surgeries and spare patients of receiving general anesthesia...
September 2017: Pain Management
https://www.readbyqxmd.com/read/28936912/epidural-hematoma-development-contralateral-to-dura-after-lumbar-transforaminal-epidural-steroid-injection
#8
Semih Gungor, Rohit Aiyer
AIM: To illustrate the anatomical and pathophysiological risks of epidural hematoma formation, other than direct needle trauma, after lumbar transforaminal epidural steroid injection in the setting of severe central canal stenosis. CASE REPORT: This case report presents the development of an epidural hematoma after lumbar transforaminal epidural steroid injection in a patient who has anatomical risk factor of severe lumbar spinal stenosis. The anatomic location of epidural hematoma was at the injected level, but on the contralateral side of the dura at a distance from the needle path...
September 2017: Pain Management
https://www.readbyqxmd.com/read/28936911/postoperative-transient-blindness-after-general-anesthesia-and-surgery-case-report-of-conversion-disorder
#9
Semih Gungor, Rohit Aiyer
Postoperative acute visual loss due to organic pathology has been described after spinal surgery in the prone position. This report describes a case of transient postoperative blindness in a patient after general anesthesia and surgery in the prone position. Postoperative workup did not reveal any organic pathology. Unbeknown to the treating physicians, the patient had a comorbid untreated psychiatric history. Upon psychiatric consultation, the patient was diagnosed with conversion disorder as a cause of postoperative blindness...
September 2017: Pain Management
https://www.readbyqxmd.com/read/28936909/predictors-of-chronic-pain-following-total-knee-replacement-in-females-and-males-an-exploratory-study
#10
Tanja Bossmann, Torsten Brauner, Scott Wearing, Thomas Horstmann
AIM: This study explored whether nociceptive (NS) and autonomic nervous system (ANS) dysregulation and psychological distress were predictive of pain 6 months after primary total knee replacement. PATIENTS & METHODS: ANS and NS regulation, psychological distress and self-reported pain, stiffness and function were evaluated preoperatively in 56 patients. Pain severity measured 6 months after surgery was used as the primary outcome in an analysis of covariance model...
September 2017: Pain Management
https://www.readbyqxmd.com/read/28936908/central-neuraxial-analgesia-for-labor-an-update-of-the-literature
#11
Serena Sodha, Alexandra Reeve, Roshan Fernando
Numerous techniques are in use to provide analgesia for labor, of which central neuraxial block is widely considered superior to non-neuraxial options. Central neuraxial techniques have evolved over many years to provide greater efficacy, safety and maternal satisfaction. This narrative review focuses on the literature relating to central neuraxial labor analgesia from the past 5 years, from November 2010 to October 2015. We discuss the evidence related to the various central neuraxial techniques used, the increasingly widespread use of ultrasound guidance and the evidence surrounding other novel methods of central neuraxial block insertion...
September 2017: Pain Management
https://www.readbyqxmd.com/read/28936905/microwave-diathermy-and-transcutaneous-electrical-nerve-stimulation-effects-in-primary-dysmenorrhea-clinical-trial-protocol
#12
Aline Fernanda Perez Machado, Monica Rodrigues Perracini, Ariane da Cruz Saraiva de Morais, Bruna Oliveira da Silva, Patricia Driusso, Richard Eloin Liebano
The aim of this study will be to analyze the effects of microwave diathermy (MWD) and transcutaneous electrical nerve stimulation (TENS) on primary dysmenorrhea. Eighty eight women, age range 18-44 years, with no previous pregnancy, no practice physical activities, a BMI of ≤29.9 kg/m(2), a regular menstrual cycle and a diagnosis of primary dysmenorrhea, with menstrual pain ranging from mild to severe, will be selected. The participants will be randomized into four groups: MWD and TENS, MWD and placebo TENS, placebo MWD and TENS, and placebo MWD and placebo TENS...
September 2017: Pain Management
https://www.readbyqxmd.com/read/28936904/pharmacophobia-and-pharmacophilia-in-analgesic-use
#13
Parisa Gazerani
No abstract text is available yet for this article.
September 2017: Pain Management
https://www.readbyqxmd.com/read/28589749/safety-of-parecoxib-when-used-for-more-than-3-days-for-the-management-of-postoperative-pain
#14
Margaret Noyes Essex, Raymond Cheung, Chunming Li, Li Xie
AIM: To assess parecoxib safety when used for >3 days for postoperative pain management. METHODS: Treatment-emergent adverse event (TEAE) occurrence after day 3 was examined in a pooled analysis of three placebo-controlled trials of parecoxib following general or gynecologic surgery, or total hip arthroplasty. A total of 358 patients received parecoxib, and 318 placebo. RESULTS: Mean treatment duration was similar between treatment groups...
September 2017: Pain Management
https://www.readbyqxmd.com/read/28814158/a-phase-i-study-of-the-pharmacokinetics-safety-and-tolerability-of-a-novel-tocopheryl-phosphate-mixture-oxymorphone-transdermal-patch-system
#15
Paul D Gavin, Lee S Simon, Thomas Schlagheck, Alisha J Smith, Janakan Krishnarajah
AIM: Characterize the pharmacokinetic profile and tolerability of two tocopheryl phosphate mixture/oxymorphone patch formulations in healthy subjects, and the active metabolite (6-OH-oxymorphone). MATERIALS & METHODS: Fifteen participants received a single application of oxymorphone patches +/- capsaicin for 72 h and were crossed-over for another 72 h. RESULTS: Plasma oxymorphone was detected approximately 7 h and 6-OH-oxymorphone after approximately 18-19 h postapplication of both formulations, respectively...
August 17, 2017: Pain Management
https://www.readbyqxmd.com/read/28805147/a-comparison-of-transdermal-over-the-counter-lidocaine-3-6-menthol-1-25-rx-lidocaine-5-and-placebo-for-back-pain-and-arthritis
#16
Eric Castro, David Dent
AIM: Transdermal lidocaine therapy has become a gold standard as part of a treatment regimen for patients who suffer from localized pain. We compared transdermal patches: over-the-counter (OTC) lidocaine 3.6% combined with menthol 1.25%, prescription lidocaine 5% (Rx) and placebo. METHODS: In a double-blind, placebo-controlled trial, 87 patients were randomized to: OTC, Rx or placebo. RESULTS: OTC met primary end points of noninferiority compared with Rx for efficacy, side effects and quality of life...
August 14, 2017: Pain Management
https://www.readbyqxmd.com/read/28793825/controlling-acute-pain-to-improve-the-quality-of-postoperative-pain-management-an-update-from-the-european-society-of-regional-anesthesia-meeting-held-in-maastricht-september-2016
#17
Jose De Andrés, Esther Pogatzki-Zahn, Frank Huygen, Edmund Neugebauer, William Fawcett
Improvement in postoperative pain management remains a global concern with a significant unmet need for patients. This was the focus of a 'Change Pain' session at the 35th European Society of Regional Anesthesia meeting (Maastricht, September 2016). Awareness of the size and nature of the problem is important to improve postoperative pain management strategies. Optimal treatment of acute pain should aim to avoid long-term sequelae such as the development of chronic pain disorders (e.g., phantom limb pain)...
August 10, 2017: Pain Management
https://www.readbyqxmd.com/read/28762282/ketamine-miracle-drug-or-latest-fad
#18
Aneesh P Goel, Dermot P Maher, Steven P Cohen
No abstract text is available yet for this article.
August 1, 2017: Pain Management
https://www.readbyqxmd.com/read/28747087/safety-and-effectiveness-of-once-daily-hysingla-extended-release-tablets-in-patients-with-baseline-depression-or-anxiety
#19
Louise Taber, Ellie He, Steven R Ripa
AIM: Long-term safety and effectiveness of a once daily, single-entity, extended-release formulation of hydrocodone bitartrate (HYD) for the treatment of moderate to severe noncancer and nonneuropathic pain among patients with and without concurrent depression/anxiety at baseline. MATERIALS & METHODS: Post hoc analysis. RESULTS: HYD demonstrated a safety profile consistent with μ-opioid agonists: Serious adverse events in 12% patients with depression/anxiety including four deaths; 6% without depression/anxiety including one death...
July 27, 2017: Pain Management
https://www.readbyqxmd.com/read/28741429/rapid-systemic-delivery-of-zolmitriptan-using-an-adhesive-dermally-applied-microarray
#20
Donald J Kellerman, Mahmoud Ameri, Stewart J Tepper
Adhesive Dermally-Applied Microarray (ADAM) is a device for intracutaneous drug administration consisting of a 3 cm(2) disposable array of drug-coated titanium microprojections on an adhesive backing. It is applied using a low cost, reusable, handheld applicator. Microprojections penetrate the stratum corneum, delivering drug proximal to capillaries with limited likelihood of pain. The pharmacokinetics of zolmitriptan delivery using ADAM was evaluated in 20 healthy volunteers. Median tmax was <20 min, comparable to subcutaneous sumatriptan...
July 25, 2017: Pain Management
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