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Pain Management

Sameer Jain, Hsiangkuo Yuan, Nicole Spare, Stephen D Silberstein
Migraine is a highly prevalent neurological pain syndrome, and its management is limited due to side effects posed by current preventive therapies. Calcitonin gene-related peptide (CGRP) plays a crucial role in the pathogenesis of migraine. In recent years, research has been dedicated to the development of monoclonal antibodies against CGRP and CGRP receptors for the treatment of migraine. This review will focus on the first US FDA-approved CGRP-receptor monoclonal antibody developed for the prevention of migraine: erenumab...
September 21, 2018: Pain Management
Jessica A Boyette-Davis, Saiyun Hou, Salahadin Abdi, Patrick M Dougherty
The burdensome condition of chemotherapy-induced peripheral neuropathy occurs with various chemotherapeutics, including bortezomib, oxaliplatin, paclitaxel and vincristine. The symptoms, which include pain, numbness, tingling and loss of motor function, can result in therapy titrations that compromise therapy efficacy. Understanding the mechanisms of chemotherapy-induced peripheral neuropathy is therefore essential, yet incompletely understood. The literature presented here will address a multitude of molecular and cellular mechanisms, beginning with the most well-understood cellular and molecular-level changes...
September 13, 2018: Pain Management
Christina Wh Cheng, Clara Sm Wong, Grace Km Hui, Edmond Kn Chung, Steven Hs Wong
Fibromyalgia is a chronic pain syndrome of unclear pathophysiology. It is believed to be a dysfunction of the CNS, but no definite structural lesion has been identified so far. Despite a number of changes in the diagnostic criteria, diagnosis remains a clinical one. Since the 2011 revision of the IASP definition of neuropathic pain, fibromyalgia has been excluded from the diagnosis of neuropathic pain. More recent studies however found newer evidences of pathophysiology including small fiber neuropathy in patients with fibromyalgia...
September 13, 2018: Pain Management
Tejus Anantharamu, Mathur A Govind
No abstract text is available yet for this article.
September 13, 2018: Pain Management
Oscar Diaz-Cambronero, Guido Mazzinari, Juan P Cata
AIM: To summarize the literature on the long-term impact of perioperative opioids in colorectal cancer. MATERIALS & METHODS: Combined results from two searching strategies in PubMed/MEDLINE (1950-2018), based on a PICO approach; P: Opioid influence on cancer-related long-term outcome in patient undergoing colorectal surgery; I: Opioid drugs administered in the perioperative period; C: Correlation between dose and/or type of opioid with long-term oncologic outcome; O: Disease-free survival and/or overall survival (OS)...
September 13, 2018: Pain Management
Marjorie Flahaut, Nicolas L Laurent, Murielle Michetti, Nathalie Hirt-Burri, Winnie Jensen, Romulus Lontis, Lee A Applegate, Wassim Raffoul
AIM: Limb amputation traumatically alters body image. Sensations rapidly prevail that the limb is still present and 85% of patients portray phantom limb pain. Throughout the testimonies of amputated patients with intense phantom limb pain, we show the difficulty in treating this chronic pain with current pharmacological and nonpharmacological therapies. PATIENTS & METHODS: We qualitatively analyzed the therapeutic choices of five amputees, the effectiveness of the treatments chosen and the impact on patients' quality-of-life...
September 3, 2018: Pain Management
Jessie S Channell, Stephan Schug
BACKGROUND: Tapentadol is a novel atypical opioid. Anecdotal evidence suggests that tapentadol has a lower toxicity than conventional opioids. OBJECTIVES: To evaluate all single-drug mortality due to tapentadol and assess serious adverse events caused by tapentadol. METHODS: The Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) reporting guidelines, an evidence-based minimum set of items for reporting in systematic reviews, were followed in this systematic review...
August 6, 2018: Pain Management
Rachel G Henderson, Ricardo E Colberg
There are limited treatment options for patients with a chronic refractory greater trochanteric pain syndrome. Orthobiologic interventions may stimulate tendon healing and improve pain and function in patients who fail the standard conservative treatment. Since the US FDA's new position statement regarding the centrifugation of bone marrow aspirate products as a potentially 'more than minimally manipulated' product, there is a growing concern about the most common bone marrow aspirate concentrate technique...
July 1, 2018: Pain Management
Anthony Plunkett, Amy McCoart, Robin S Howard, Elizabeth Dennison, Michael Bartoszek
AIM: The purpose of this randomized, single-blind trial was to evaluate the efficacy of battlefield acupuncture in reducing postoperative pain and opioid consumption after adult tonsillectomy. METHODS: Adult participants undergoing a tonsillectomy were randomized to either receive auricular 'battlefield' acupuncture or not. Groups were compared using the Wilcox rank sum test, Fisher's exact test and a generalized estimating equations model for post-discharge pain scores...
July 1, 2018: Pain Management
Livia Puljak, Svjetlana Dosenovic, Krste Boric
No abstract text is available yet for this article.
July 1, 2018: Pain Management
Jana Sawynok
No abstract text is available yet for this article.
July 1, 2018: Pain Management
Luda Diatchenko
Luda Diatchenko, MD, PhD is a Canada Excellence Research Chair in Human Pain Genetics, Professor, Faculty of Medicine, Department of Anesthesia and Faculty of Dentistry at McGill University, Alan Edwards Centre for Research on Pain. She earned her MD and PhD in the field of molecular biology from the Russian State Medical University. She started her career in industry, she was a Leader of the RNA Expression Group at Clontech, Inc., and subsequently, Director of Gene Discovery at Attagene, Inc. During this time, she was actively involved in the development of several widely used and widely cited molecular tools for the analysis of gene expression and regulation...
July 1, 2018: Pain Management
Ke-Vin Chang, Wei-Ting Wu, Levent Özçakar
No abstract text is available yet for this article.
July 1, 2018: Pain Management
Jonathan Daniel Telles, Marco Aurélio Gabanela Schiavon, Érika Patrícia Rampazo da Silva, Richard Eloin Liebano
AIM: Transcutaneous electrical nerve stimulation (TENS) and cervical joint manipulation (CJM) are often used for pain treatment. METHODS: A total of 144 healthy subjects will be randomly allocated into four groups: active TENS and CJM, placebos TENS and CJM, placebo TENS and active CJM, active TENS and placebo CJM. TENS will be applied for 20 min followed by CJM. All subjects will be assessed before, during and after interventions, using a digital pressure algometer...
July 1, 2018: Pain Management
Renée J Heerkens, Albère Ja Köke, Freek Jb Lötters, Rob Jem Smeets
AIM: This study aims to gain more knowledge of the sensorimotor incongruence in patients with chronic nonspecific complaints of arm, neck and shoulder. METHOD: Seven patients and seven healthy controls performed a left/right judgment task, and tactile acuity was assessed by the two-point discrimination threshold at fingers and shoulders. RESULTS & CONCLUSION: The results suggest a decreased tactile acuity in patients with chronic nonspecific complaints of arm, neck and shoulder and a faster reaction time at the painful arm, which might imply disturbed information processing of sensory and motor feedback...
July 1, 2018: Pain Management
Peter Schmidt, Srinivas Rao
AIM: Randomized Phase I study examining the effects of gabapentinoids gabapentin, pregabalin and gastroretentive gabapentin on simulated driving performance, sedation and cognitive function in healthy volunteers (n = 32). METHODS: Driving attentiveness, sleepiness and cognition were evaluated prior to subjects receiving study doses. Blood samples were collected during each treatment. RESULTS: Subjects receiving gastroretentive gabapentin showed less change in variation in lateral lane position (p = 0...
July 1, 2018: Pain Management
César Fernández-de-Las-Peñas, Gustavo Plaza-Manzano
Carpal tunnel syndrome (CTS) is considered just a peripheral neuropathy of the upper extremity associated to the compression of the median nerve. There is evidence suggesting the presence of complex sensitization mechanisms in CTS. These processes are manifested by symptoms in extra-median regions and the presence of bilateral sensory and motor impairments. These sensory and motor changes are not associated to electrodiagnostic findings. The presence of sensitization mechanisms suggests that CTS should not be considered just as a peripheral neuropathy...
June 5, 2018: Pain Management
César Amescua García, Joao Batista Santos Garcia, María Del Rosario Berenguel Cook, Frantz Colimon, José Alberto Flores Cantisani, Carlos Guerrero, María Del Rocío Guillén Núnez, John Jairo Hernández Castro, Durval Campos Kraychete, Argelia Lara-Solares, Osvandré Lech, María Antonieta Rico Pazos, Manuel Sempértegui Gallegos, Lizandra Pattaro Marcondes
Pain is highly prevalent among the adult Latin American population. However, many patients with moderate to severe pain do not have access to effective pain management with opioids due to limited access to healthcare, overuse of nonopioid analgesics, regulatory barriers and lack of appropriate information about opioids. There is scarce training on use of opioids among physicians and other healthcare providers, which leads to misconceptions, mainly related to a fear of prescribing opioids. Although opioids are safe and effective drugs for the treatment of moderate to severe chronic pain, the use of opioids in Latin American nations is clearly below standards compared with developed countries...
May 2018: Pain Management
Andy Whelan, Mark I Johnson
Recently, there has been interest in lysergic acid diethylamide (LSD) and psilocybin for depression, anxiety and fear of death in terminal illness. The aim of this review is to discuss the potential use of LSD and psilocybin for patients with persistent pain. LSD and psilocybin are 5-hydroxytryptamine receptor agonists and may interact with nociceptive and antinociceptive processing. Tentative evidence from a systematic review suggests that LSD (7 studies, 323 participants) and psilocybin (3 studies, 92 participants) may be beneficial for depression and anxiety associated with distress in life-threatening diseases...
May 2018: Pain Management
Rudnick Chad, Sulaiman Emaan, Orden Jillian
AIM: Fear of needles is a well-known phobia among children and adults. This study presents the rationale, feasibility and results of a pilot study applying a virtual reality (VR) headset as a fear reduction and pain distraction during immunizations. PATIENTS & METHODS: 17 subjects and 17 parents rated their fear and pain level pre- and postimmunization using Wong-Baker pain scale and McMurtry children's fear scale. Immunization was provided, while subject was wearing a VR headset...
May 2018: Pain Management
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