journal
MENU ▼
Read by QxMD icon Read
search

Frontiers in Endocrinology

journal
https://www.readbyqxmd.com/read/30008698/neuropeptide-g-protein-coupled-receptors-as-oncotargets
#1
REVIEW
Terry W Moody, Irene Ramos-Alvarez, Robert T Jensen
Neuropeptide G protein-coupled receptors (GPCRs) are overexpressed on numerous cancer cells. In a number of tumors, such as small cell lung cancer (SCLC), bombesin (BB) like peptides and neurotensin (NTS) function as autocrine growth factors whereby they are secreted from tumor cells, bind to cell surface receptors and stimulate growth. BB-drug conjugates and BB receptor antagonists inhibit the growth of a number of cancers. Vasoactive intestinal peptide (VIP) increases the secretion rate of BB-like peptide and NTS from SCLC leading to increased proliferation...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30008697/xrk3f2-inhibition-of-p62-zz-domain-signaling-rescues-myeloma-induced-gfi1-driven-epigenetic-repression-of-the-runx2-gene-in-pre-osteoblasts-to-overcome-differentiation-suppression
#2
Juraj Adamik, Rebecca Silbermann, Silvia Marino, Quanhong Sun, Judith L Anderson, Dan Zhou, Xiang-Qun Xie, G David Roodman, Deborah L Galson
Multiple myeloma bone disease (MMBD) is characterized by non-healing lytic bone lesions that persist even after a patient has achieved a hematologic remission. We previously reported that p62 (sequestosome-1) in bone marrow stromal cells (BMSC) is critical for the formation of MM-induced signaling complexes that mediate OB suppression. Importantly, XRK3F2, an inhibitor of the p62-ZZ domain, blunted MM-induced Runx2 suppression in vitro , and induced new bone formation and remodeling in the presence of tumor in vivo ...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30008696/impact-of-maternal-age-on-oocyte-and-embryo-competence
#3
REVIEW
Danilo Cimadomo, Gemma Fabozzi, Alberto Vaiarelli, Nicolò Ubaldi, Filippo Maria Ubaldi, Laura Rienzi
The overall success of human reproduction, either spontaneously or after IVF, is highly dependent upon maternal age. The main reasons for age-related infertility include reduced ovarian reserve and decreased oocyte/embryo competence due to aging insults, especially concerning an increased incidence of aneuploidies and possibly decreased mitochondrial activity. Age-related chromosomal abnormalities mainly arise because of meiotic impairments during oogenesis, following flawed chromosome segregation patterns such as non-disjunction, premature separation of sister chromatids, or the recent reverse segregation...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30002647/cryopreservation-of-ovarian-tissue-opportunities-beyond-fertility-preservation-and-a-positive-view-into-the-future
#4
REVIEW
Stine G Kristensen, Claus Y Andersen
In current years, ovarian tissue cryopreservation (OTC) and transplantation is gaining ground as a successful method of preserving fertility in young women with primarily cancer diseases, hereby giving them a chance of becoming biological mothers later on. However, OTC preserves more than just the reproductive potential; it restores the ovarian endocrine function and thus the entire female reproductive cycle with natural levels of essential hormones. In a female population with an increased prevalence in the loss of ovarian function due to induced primary ovarian insufficiency (POI) and aging, there is now, a need to develop new treatments and provide new opportunities to utilize the enormous surplus of follicles that most females are born with and overcome major health issues associated with the lack of ovarian hormones...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30002646/prep1-a-homeodomain-transcription-factor-involved-in-glucose-and-lipid-metabolism
#5
REVIEW
Francesco Oriente, Giuseppe Perruolo, Ilaria Cimmino, Serena Cabaro, Antonietta Liotti, Michele Longo, Claudia Miele, Pietro Formisano, Francesco Beguinot
The three-amino acid loop extension (TALE) homeodomain proteins are a family of transcription factor including the mammalian Pbx, MEIS and Prep proteins. TALE proteins can bind other transcription factors such as Pdx-1 and play an important role in the regulation of glucose metabolism. Experiments performed in mutant mice have shown that while the single Pbx1 or Pdx-1 knockout mice feature pancreatic islet malformations, impaired glucose tolerance and hypoinsulinemia, the trans-heterozygous Pbx1 +/- Pdx1 +/- mice develop age-dependent overt diabetes mellitus...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29997576/short-body-height-and-pre-pregnancy-overweight-for-increased-risk-of-gestational-diabetes-mellitus-a-population-based-cohort-study
#6
Jing Li, Peng Wang, Cuiping Zhang, Junhong Leng, Nan Li, Leishen Wang, Wei Li, Huikun Liu, Zhijie Yu, Gang Hu, Juliana C N Chan, Xilin Yang
Background: Short height is associated with gestational diabetes mellitus (GDM) but the underlying mechanism remains unknown. This study aims to explore whether short height has a synergistic effect with pre-pregnancy overweight/obesity and undue weight gain on the risk of GDM. Methods: We recruited 19,962 singleton pregnant women from their first antenatal care visit in urban Tianjin, China, between October 2010 to August 2012. At 24-28 weeks of gestation, women underwent a 50-g 1-h glucose challenge test (GCT) followed by a 75-g 2-h oral glucose tolerance test (OGTT) if the GCT result was ≥7...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29997575/what-has-bariatric-surgery-taught-us-about-the-role-of-the-upper-gastrointestinal-tract-in-the-regulation-of-postprandial-glucose-metabolism
#7
REVIEW
Jing Ma, Adrian Vella
The interaction between the upper gastrointestinal tract and the endocrine system is important in the regulation of metabolism and of weight. The gastrointestinal tract has a heterogeneous cellular content and comprises a variety of cells that elaborate paracrine and endocrine mediators that collectively form the entero-endocrine system. The advent of therapy that utilizes these pathways as well as the association of bariatric surgery with diabetes remission has (re-)kindled interest in the role of the gastrointestinal tract in glucose homeostasis...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29988450/modulation-of-amyloidogenesis-controlled-by-the-c-terminal-domain-of-islet-amyloid-polypeptide-shows-new-functions-on-hepatocyte-cholesterol-metabolism
#8
Angel Pulido-Capiz, Raúl Díaz-Molina, Israel Martínez-Navarro, Lizbeth A Guevara-Olaya, Enrique Casanueva-Pérez, Jaime Mas-Oliva, Ignacio A Rivero, Victor García-González
The islet amyloid polypeptide (IAPP) or amylin maintains a key role in metabolism. This 37-residues-peptide could form pancreatic amyloids, which are a characteristic feature of diabetes mellitus type 2. However, some species do not form amyloid fibril structures. By employing a biomimetic approach, we generated an extensive panel of optimized sequences of IAPP, which could drastically reduce aggregation propensity. A structural and cellular characterization analysis was performed on the C-terminal domain with the highest aggregation propensity...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29988396/impact-of-intestinal-peptides-on-the-enteric-nervous-system-novel-approaches-to-control-glucose-metabolism-and-food-intake
#9
REVIEW
Anne Abot, Patrice D Cani, Claude Knauf
The gut is one of the most important sources of bioactive peptides in the body. In addition to their direct actions in the brain and/or peripheral tissues, the intestinal peptides can also have an impact on enteric nervous neurons. By modifying the endogenousproduction of these peptides, one may expect modify the "local" physiology such as glucose absorption, but also could have a "global" action via the gut-brain axis. Due to the various origins of gut peptides (i.e., nutrients, intestinal wall, gut microbiota) and the heterogeneity of enteric neurons population, the potential physiological parameters control by the interaction between the two partners are multiple...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29988390/peculiarities-of-precocious-puberty-in-boys-and-girls-with-mccune-albright-syndrome
#10
REVIEW
Domenico Corica, Tommaso Aversa, Giorgia Pepe, Filippo De Luca, Malgorzata Wasniewska
McCune-Albright Syndrome (MAS; OMIM # 174800) is a rare, sporadic disease caused by a post-zygotic, activating mutation in the guanine-nucleotide binding protein α-subunit ( GNAS1 ) gene. MAS is characterized by the clinical triad of polyostotic fibrous dysplasia of bone, café-au-lait skin pigmentation and peripheral precocious puberty. However, clinical presentation is highly variable depending on mosaic tissue distribution of mutant-bearing cells. Precocious puberty is the most common endocrine manifestation of MAS and is often the presenting, and sometimes the only, clinical sign of MAS...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29977228/circadian-regulation-of-glutamate-transporters
#11
REVIEW
Donají Chi-Castañeda, Arturo Ortega
L-glutamate is the major excitatory amino acid in the mammalian central nervous system (CNS). This neurotransmitter is essential for higher brain functions such as learning, cognition and memory. A tight regulation of extra-synaptic glutamate levels is needed to prevent a neurotoxic insult. Glutamate removal from the synaptic cleft is carried out by a family of sodium-dependent high-affinity transporters, collectively known as excitatory amino acid transporters. Dysfunction of glutamate transporters is generally involved in acute neuronal injury and neurodegenerative diseases, so characterizing and understanding the mechanisms that lead to the development of these disorders is an important goal in the design of novel treatments for the neurodegenerative diseases...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29977227/mechanisms-underlying-the-synergistic-action-of-insulin-and-growth-hormone-on-igf-i-and-ii-expression-in-grass-carp-hepatocytes
#12
Quan Jiang, Jin Bai, Mulan He, Karen W Y Yuen, Anderson O L Wong
In mammals, insulin is known to modify growth hormone (GH)-induced IGF-I expression at the hepatic level, which also contributes to the functional crosstalk between energy homeostasis and somatotropic axis. However, the studies on the comparative aspects of this phenomenon are limited and the mechanisms involved have not been fully characterized. Using a serum-free culture of grass carp hepatoctyes, the functional interaction between GH and insulin on hepatic expression of IGF-I and -II was examined in a fish model...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29977226/impact-of-altered-mineral-metabolism-on-pathological-cardiac-remodeling-in-elevated-fibroblast-growth-factor-23
#13
Maren Leifheit-Nestler, Beatrice Richter, Melis Basaran, Julia Nespor, Isabel Vogt, Ioana Alesutan, Jakob Voelkl, Florian Lang, Joerg Heineke, Stefanie Krick, Dieter Haffner
Clinical and experimental studies indicate a possible link between high serum levels of fibroblast growth factor 23 (FGF23), phosphate, and parathyroid hormone (PTH), deficiency of active vitamin D (1,25D) and klotho with the development of pathological cardiac remodeling, i.e., left ventricular hypertrophy and myocardial fibrosis, but a causal link has not been established so far. Here, we investigated the cardiac phenotype in klotho hypomorphic ( kl/kl ) mice and Hyp mice, two mouse models of elevated FGF23 levels and klotho deficiency, but differing in parameters of mineral metabolism, by using histology, quantitative real-time PCR, immunoblot analysis, and serum and urine biochemistry...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29977225/role-of-chemokines-in-thyroid-cancer-microenvironment-is-cxcl8-the-main-player
#14
REVIEW
Mario Rotondi, Francesca Coperchini, Francesco Latrofa, Luca Chiovato
Tumor-related inflammation does influence the biological behavior of neoplastic cells and ultimately the patient's outcome. With specific regard to thyroid cancer, the issue of tumor-associated inflammation has been extensively studied and recently reviewed. However, the role of chemokines, which play a crucial role in determining the immuno-phenotype of tumor-related inflammation, was not addressed in previous reviews on the topic. Experimental evidence shows that thyroid cancer cells actively secrete a wide spectrum of chemokines and, at least for some of them, solid scientific data support a role for these immune-active molecules in the aggressive behavior of the tumor...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29973915/nonalcoholic-fatty-liver-disease-in-university-rugby-football-players
#15
Shinsuke Nirengi, Mami Fujibayashi, Sachiko Furuno, Akihiko Uchibe, Yasuharu Kawase, Shin Sukino, Yaeko Kawaguchi, Satomi Minato, Kazuhiko Kotani, Naoki Sakane
Physical activity improves various metabolic disturbances. The effect of physical activity on non-alcoholic fatty liver disease (NAFLD) has not been defined, particularly in athletes who are able to consume a diet to increase body mass. The aim of this study was to evaluate the prevalence of NAFLD and associated factors of NAFLD among male university rugby football players [ n = 69, 37 forwards (FW) and 32 backs (BK)], relative to age-matched controls (CON; n = 29). For FW players exercise consists of physical contact play, such as ruck, mall, scrum, and tackle...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29971044/the-role-of-semaphorin-4d-in-bone-remodeling-and-cancer-metastasis
#16
REVIEW
Konstantinos Lontos, Juraj Adamik, Anastasia Tsagianni, Deborah L Galson, John M Chirgwin, Attaya Suvannasankha
Semaphorin 4D (Sema4D; CD100) is a transmembrane homodimer 150-kDa glycoprotein member of the Semaphorin family. Semaphorins were first identified as chemorepellants that guide neural axon growth. Sema4D also possesses immune regulatory activity. Recent data suggest other Sema4D functions: inactivation of platelets, stimulation of angiogenesis, and regulation of bone formation. Sema4D is a coupling factor expressed on osteoclasts that inhibits osteoblast differentiation. Blocking Sema4D may, therefore, be anabolic for bone...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29967592/androgen-receptor-camkk2-axis-in-prostate-cancer-and-bone-microenvironment
#17
REVIEW
Ushashi C Dadwal, Eric S Chang, Uma Sankar
The skeletal system is of paramount importance in advanced stage prostate cancer (PCa) as it is the preferred site of metastasis. Complex mechanisms are employed sequentially by PCa cells to home to and colonize the bone. Bone-resident PCa cells then recruit osteoblasts (OBs), osteoclasts (OCs), and macrophages within the niche into entities that promote cancer cell growth and survival. Since PCa is heavily reliant on androgens for growth and survival, androgen-deprivation therapy (ADT) is the standard of care for advanced disease...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29967591/correlation-between-oral-lichen-planus-and-thyroid-disease-in-china-a-case-control-study
#18
Tingting Zhou, Dan Li, Qianming Chen, Hong Hua, Chunlei Li
Background: A possible relationship between oral lichen planus (OLP) and thyroid disease has received attention in recent years. Objective: This study aimed to evaluate the correlation between OLP and thyroid diseases in Chinese ethnic patients. Methods: 192 OLP patients, 123 patients with oral lichenoid lesions (OLLs), and 162 controls were recruited in this case-control study. All participants received screening for thyroid function and underwent ultrasound...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29967590/brain-derived-steroids-behavior-and-endocrine-conflicts-across-life-history-stages-in-birds-a-perspective
#19
John C Wingfield, Douglas W Wacker, George E Bentley, Kazuyoshi Tsutsui
Biological steroids were traditionally thought to be synthesized exclusively by the adrenal glands and gonads. Recent decades have seen the discovery of neurosteroid production that acts locally within the central nervous system to affect physiology and behavior. These actions include, for example, regulation of aggressive behavior, such as territoriality, and locomotor movement associated with migration. Important questions then arose as to how and why neurosteroid production evolved and why similar steroids of peripheral origin do not always fulfill these central roles? Investigations of free-living vertebrates suggest that synthesis and action of bioactive steroids within the brain may have evolved to regulate expression of specific behavior in different life history stages...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29963015/role-of-hormonal-circuitry-upon-t-cell-development-in-chagas-disease-possible-implications-on-t-cell-dysfunctions
#20
REVIEW
Ana Rosa Pérez, Alexandre Morrot, Vinicius Frias Carvalho, Juliana de Meis, Wilson Savino
T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi , the causative agent of Chagas disease. This infection is often associated with multiple manifestations of T cell dysfunction, both during the acute and the chronic phases of disease. Additionally, the normal development of T cells is affected. As seen in animal models of Chagas disease, there is a strong thymic atrophy due to massive death of CD4+ CD8+ double-positive cells by apoptosis and an abnormal escape of immature and potentially autoreactive thymocytes from the organ...
2018: Frontiers in Endocrinology
journal
journal
43491
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"