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Therapeutic Advances in Psychopharmacology

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https://www.readbyqxmd.com/read/30065814/dilemmas-in-the-treatment-of-early-onset-first-episode-psychosis
#1
REVIEW
Daniel Hayes, Marinos Kyriakopoulos
Early-onset first-episode psychosis (EOP) is a severe mental disorder that can pose a number of challenges to clinicians, young people and their families. Its assessment and differentiation from other neurodevelopmental and mental health conditions may at times be difficult, its treatment may not always lead to optimal outcomes and can be associated with significant side effects, and its long-term course and prognosis seem to be less favourable compared with the adult-onset disorder. In this paper, we discuss some dilemmas associated with the evaluation and management of EOP and propose approaches that can be used in the clinical decision-making process...
August 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/30065813/predicting-rehospitalization-in-patients-treated-with-antipsychotics-a-prospective-observational-study
#2
Heshu Abdullah-Koolmees, Helga Gardarsdottir, Lotte A Minnema, Kamjar Elmi, Lennart J Stoker, Judith Vuyk, Laurette E Goedhard, Toine C G Egberts, Eibert R Heerdink
Background: Prediction of rehospitalization in patients treated with antipsychotics is important for identifying patients in need of additional support to prevent hospitalization. Our aim was to identify factors that predict rehospitalization in patients treated with antipsychotics at discharge from a psychiatric hospital. Methods: Adult patients suffering from schizophrenia, psychotic or bipolar I disorders who had been hospitalized in a psychiatric hospital for ⩾7 days and were treated with oral antipsychotics at discharge were included...
August 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29977520/psychiatric-manifestations-in-wilson-s-disease-possibilities-and-difficulties-for-treatment
#3
REVIEW
Tomasz Litwin, Petr Dusek, Tomasz Szafrański, Karolina Dzieżyc, Anna Członkowska, Janusz K Rybakowski
Wilson's disease (WD) is an inherited metabolic disorder related to disturbances of copper metabolism, and predominantly presents with liver and neuropsychiatric symptoms. In most cases it can be successfully treated with anti-copper agents, and both liver function and neuropsychiatric symptoms typically improve. Treatment guidelines for WD include recommendations for anti-copper treatment as well as for the treatment of liver failure symptoms. Recently, recommendations for treatment of the neurological symptoms of WD have also been proposed...
July 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29977519/amisulpride-augmentation-of-clozapine-for-treatment-refractory-schizophrenia-a-double-blind-placebo-controlled-trial
#4
Thomas R E Barnes, Verity Leeson, Carol Paton, Louise Marston, David P Osborn, Raj Kumar, Patrick Keown, Rameez Zafar, Khalid Iqbal, Vineet Singh, Pavel Fridrich, Zachary Fitzgerald, Hemant Bagalkote, Peter M Haddad, Mariwan Husni, Tim Amos
Background: A second antipsychotic is commonly added to clozapine to treat refractory schizophrenia, notwithstanding the limited evidence to support such practice. Methods: The efficacy and adverse effects of this pharmacological strategy were examined in a double-blind, placebo-controlled, 12-week randomized trial of clozapine augmentation with amisulpride, involving 68 adults with treatment-resistant schizophrenia and persistent symptoms despite a predefined trial of clozapine...
July 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29977518/rethinking-the-spectrum-of-mood-disorders-implications-for-diagnosis-and-management-proceedings-of-a-symposium-presented-at-the-30th-annual-european-college-of-neuropsychopharmacology-congress-4-september-2017-paris-france
#5
REVIEW
Roger S McIntyre, Allan H Young, Peter M Haddad
The simultaneous occurrence of manic and depressive features has been recognized since classical times, but the term 'mixed state' was first used by Kraepelin at the end of the 19th century. From the 1980s, until the advent of the Diagnostic and Statistical Manual of Mental Disorders , fifth edition (DSM-5), psychiatric disorders were classified using a categorical approach. However, it was recognized that such an approach was too rigid to encompass the range of symptomatology encountered in clinical practice...
June 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29854396/switching-and-augmentation-strategies-for-antipsychotic-medications-in-acute-phase-schizophrenia-latest-evidence-and-place-in-therapy
#6
REVIEW
Kotaro Hatta, Naoya Sugiyama, Hiroto Ito
In terms of effectiveness of antipsychotics in schizophrenia, discrepancy often exists between results from double-blind randomized controlled trials and observations in emergency or acute-phase clinical practice. For instance, the antipsychotic switching strategy is not always applicable in emergency or acute-phase situations, and augmentation of another antipsychotic is occasionally done instead. In this review, we discuss strategies for early nonresponse to an antipsychotic drug such as switching and augmentation from the perspective of emergency and acute-phase treatment...
June 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29854395/naming-the-drugs-we-use-neuroscience-based-nomenclature-a-helpful-innovation
#7
EDITORIAL
Sue Wilson
No abstract text is available yet for this article.
June 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29713452/challenges-of-the-pharmacological-management-of-benzodiazepine-withdrawal-dependence-and-discontinuation
#8
REVIEW
Dimy Fluyau, Neelambika Revadigar, Brittany E Manobianco
Background: Benzodiazepines (BZDs) are among the most prescribed sedative hypnotics and among the most misused and abused medications by patients, in parallel with opioids. It is estimated that more than 100 million Benzodiazepine (BZD) prescriptions were written in the United States in 2009. While medically useful, BZDs are potentially dangerous. The co-occurring abuse of opioids and BZD, as well as increases in BZD abuse, tolerance, dependence, and short- and long-term side effects, have prompted a worldwide discussion about the challenging aspects of medically managing the discontinuation of BZDs...
May 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29713451/effectiveness-of-paliperidone-long-acting-injection-in-clinical-practice
#9
Paul Nicholas Deslandes, Elan Haf Ward, Kathryn Norris, Robert David Sewell
Background: The efficacy of the long-acting injectable formulation of the antipsychotic paliperidone (paliperidone palmitate) has been investigated in randomized controlled trials. Due to the nature of study designs, these may not be representative of usual clinical practice. The aim of this study was to assess the clinical effectiveness of the long-acting injectable antipsychotic paliperidone palmitate using treatment continuation at 1 year as an outcome. Methods: Patients were initiated on paliperidone palmitate prior to December 2014 in a single health board in Wales (UK)...
May 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29607005/the-antipsychotic-landscape-dopamine-and-beyond
#10
REVIEW
Paul D Morrison, Robin M Murray
Until recently, the actions of antipsychotic and pro-psychotic drugs have largely been evaluated in the framework of neuronal doctrine - namely, that neurons communicate by releasing transmitters, and that psychiatric disorders are caused by neurotransmitter imbalances. Moreover, the majority of studies have focused on single transmitter systems - neglecting the fact that in the nervous system, different transmitter systems work in concert and impact on not only their immediate receptors but also downstream pathways that shape structural plasticity...
April 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29607004/a-prospective-year-long-follow-up-of-lurasidone-use-in-clinical-practice-factors-predicting-treatment-persistence
#11
Ian J Osborne, Shubhra Mace, David Taylor
Background: Our aim was to follow up patients prescribed lurasidone over 1 year to determine factors predicting treatment persistence. Methods: We used noninterventional, observational, prospective follow up of patients consecutively prescribed lurasidone in a large inner-city NHS mental health trust. We also performed retrospective analysis of outcomes from patient case notes. Results: Data were available for 69 patients consecutively prescribed lurasidone, of whom three (4%) were lost to follow up...
April 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29492258/benzodiazepine-prescription-in-ontario-residents-aged-65-and-over-a-population-based-study-from-1998-to-2013
#12
Simon J C Davies, Binu Jacob, David Rudoler, Juveria Zaheer, Claire de Oliveira, Paul Kurdyak
Background: Although commonly used in anxiety and insomnia, recent guidelines recommend caution when prescribing benzodiazepines in the elderly. Here we examined rates of benzodiazepine prescribing to older adults in Ontario, Canada from 1998 to 2013 and impact of legislation that made prescribing regulations more strict. Method: Annual benzodiazepine prescription rates for Ontario residents aged 65 and over were examined using the Ontario Drug Benefit database which captures all publicly funded prescriptions...
March 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29492257/alternatives-to-ketamine-in-depression-state-of-the-art-and-future-perspectives
#13
EDITORIAL
Luke A Jelen, Sinead King, James M Stone
No abstract text is available yet for this article.
March 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29399320/neuromodulation-for-the-treatment-of-eating-disorders-and-obesity
#14
REVIEW
Darrin J Lee, Gavin J B Elias, Andres M Lozano
Eating disorders and obesity adversely affect individuals both medically and psychologically, leading to reduced life expectancy and poor quality of life. While there exist a number of treatments for anorexia, morbid obesity and bulimia, many patients do not respond favorably to current behavioral, medical or bariatric surgical management. Neuromodulation has been postulated as a potential treatment for eating disorders and obesity. In particular, deep brain stimulation and transcranial non-invasive brain stimulation have been studied for these indications across a variety of brain targets...
February 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29344345/when-the-drugs-don-t-work-treatment-resistant-schizophrenia-serotonin-and-serendipity
#15
Penelope Lowe, Amir Krivoy, Lilla Porffy, Erna Henriksdottir, Whiskey Eromona, Sukhwinder S Shergill
Treatment-resistant schizophrenia is a serious clinical problem. We adopt a systems-level approach positing a greater role for cognitive control mechanisms in the development of psychotic symptoms and illustrate the clinical application of this via a case report of treatment-resistant patients treated successfully with adjunct pro-cognitive serotonergic medication.
January 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29344344/acetylcholinesterase-inhibitors-in-treatment-resistant-psychotic-depression
#16
Chris Smart, Hamish McAllister-Williams, David Andrew Cousins
Dopamine receptor antagonists can be effective in psychotic depression but response is not assured. Visual hallucinations may arise from a dysregulation of brain cholinergic systems and acetylcholinesterase inhibitors (AChEIs) can treat such hallucinations in dementia with Lewy bodies (DLB). AChEIs have been used in schizophrenia with some success but their efficacy and tolerability in psychotic depression is unclear. This striking case illustrates AChEIs specifically targeting multimodal hallucinations in treatment-resistant depression...
January 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29344343/the-role-of-selective-serotonin-reuptake-inhibitors-in-preventing-relapse-of-major-depressive-disorder
#17
REVIEW
Steven S Clevenger, Devvrat Malhotra, Jonathan Dang, Brigitte Vanle, Waguih William IsHak
The objective of this review was to evaluate the efficacy of selective serotonin reuptake inhibitors (SSRIs) and SSRIs compared with other treatment modalities in preventing relapse after an episode of major depressive disorder (MDD). An Ovid MEDLINE and PsycINFO search (from 1987 to August 2017) was conducted using the following terms: selective serotonin reuptake inhibitors, antidepressants, depression, prevention, prophylaxis, relapse and MDD. Using predefined criteria, two authors independently selected and reached consensus on the included studies...
January 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29344342/frontotemporal-dementia-latest-evidence-and-clinical-implications
#18
REVIEW
Juan Joseph Young, Mallika Lavakumar, Deena Tampi, Silpa Balachandran, Rajesh R Tampi
Background: Frontotemporal dementia (FTD) describes a cluster of neurocognitive syndromes that present with impairment of executive functioning, changes in behavior, and a decrease in language proficiency. FTD is the second most common form of dementia in those younger than 65 years and is expected to increase in prevalence as the population ages. This goal in our review is to describe advances in the understanding of neurobiological pathology, classification, assessment, and treatment of FTD syndromes...
January 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29344341/treatment-of-adult-adhd-a-clinical-perspective
#19
REVIEW
Josh Geffen, Kieran Forster
Adult attention deficit/hyperactivity disorder (ADHD) has moved from the blurred edge of clinical focus to clear recognition as a prevalent and significant disorder in its own right. It is a relatively common comorbidity which if identified and treated may open the door to better outcomes for hard-to-treat patients. Conversely, failure to identify and treat adult ADHD is linked to negative outcomes. The recognition of the importance of adult ADHD in a subset of our patients challenges us to overcome our anxiety about this diagnosis and prevent the societal marginalization of vulnerable patients...
January 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29344340/assessment-and-management-of-sexual-dysfunction-in-the-context-of-depression
#20
REVIEW
Pratap R Chokka, Jeffrey R Hankey
Sexual dysfunction (SD) is pervasive and underreported, and its effects on quality of life are underestimated. Due in part to its bidirectional relationship with depression, SD can be difficult to diagnose; it is also a common side effect of many antidepressants, leading to treatment noncompliance. While physicians often count on patients to spontaneously report SD, treatment is optimized when the clinician instead performs a thorough assessment of sexual functioning before and during drug therapy using a standardized questionnaire such as the Arizona Sexual Experiences Scale (ASEX)...
January 2018: Therapeutic Advances in Psychopharmacology
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