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Therapeutic Advances in Psychopharmacology

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https://www.readbyqxmd.com/read/28740637/antipsychotic-induced-hyperprolactinemia-in-tourette-syndrome
#1
REVIEW
Judith J G Rath, Marlies E J Deen, Hessel van Houten, Sebastiaan F T M de Bruijn, Joop van Gerven, Dick Mul
For many years, Tourette syndrome (TS) was considered to be a rare disorder, but tics and TS are now recognized as fairly common childhood-onset conditions. Children and adolescents with TS are frequently treated with antipsychotics, either as monotherapy or in combination with psychostimulants, melatonin and selective serotonin reuptake inhibitors (SSRIs). Antipsychotics are most often used in schizophrenia and related psychotic disorders, and in these conditions hyperprolactinemia is one of the most common adverse effects associated with antipsychotics, occurring in 40-50% of patients...
July 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28740636/long-term-use-of-benzodiazepines-in-older-patients-in-germany-a-retrospective-analysis
#2
Louis Jacob, Michael A Rapp, Karel Kostev
BACKGROUND: The purpose of this study was to analyze the prevalence of long-term benzodiazepine use in older adults treated in general and neuropsychiatric practices in Germany. METHODS: This study included 32,182 patients over the age of 65 years who received benzodiazepine prescriptions for the first time between January 2010 and December 2014 in general and neuropsychiatric practices in Germany. Follow up lasted until July 2016. The main outcome measure was the proportion of patients treated with benzodiazepines for >6 months...
July 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28540039/successful-withdrawal-from-high-dose-benzodiazepine-in-a-young-patient-through-electronic-monitoring-of-polypharmacy-a-case-report-in-an-ambulatory-setting
#3
REVIEW
Hèctor R Loscertales, Valerie Wentzky, Kenneth Dürsteler, Johannes Strasser, Kurt E Hersberger, Isabelle Arnet
BACKGROUND: Dependence on high-dose benzodiazepines (BZDs) is well known and discontinuation attempts are generally unsuccessful. A well established protocol for high-dose BZD withdrawal management is lacking. We present the case of withdrawal from high-dose lorazepam (>20 mg daily) in an unemployed 35-year-old male outpatient through agonist substitution with long-acting clonazepam and electronic monitoring over 28 weeks. METHODS: All medicines were repacked into weekly 7 × 4 cavity multidose punch cards with an electronic monitoring system...
May 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28540038/effectiveness-of-paliperidone-depot-injection-in-seriously-violent-men-with-comorbid-schizophrenia-and-dissocial-personality-disorder-in-a-uk-high-security-hospital
#4
Anna-Marie Mortlock, Fintan Larkin, Callum C Ross, Nitin Gupta, Samrat Sengupta, Mrigendra Das
BACKGROUND: High-security hospital patients are often complex in presentation and are characterized by treatment resistance, medication nonadherence and history of violence. Paliperidone is licensed both as an oral and depot antipsychotic medication in the treatment of schizophrenia. Clinical trials have shown that paliperidone depot is well tolerated with similar efficacy to risperidone depot but with additional practical advantages. Whilst data exist for the effectiveness of paliperidone palmitate (PP), there are no studies involving patients in forensic settings or those with comorbid personality disorder...
May 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28540037/editorial
#5
EDITORIAL
David Taylor
No abstract text is available yet for this article.
May 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28540035/results-of-lumbar-puncture-ct-and-mri-in-a-case-of-quinacrine-induced-psychosis-involving-a-patient-with-cutaneous-lupus-erythematosus
#6
Noura Matoug Al Osaimi, Carole Richford, John Thomas Kelsall
No abstract text is available yet for this article.
April 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28540034/ayahuasca-dimethyltryptamine-and-psychosis-a-systematic-review-of-human-studies
#7
REVIEW
Rafael G Dos Santos, José Carlos Bouso, Jaime E C Hallak
Ayahuasca is a hallucinogen brew traditionally used for ritual and therapeutic purposes in Northwestern Amazon. It is rich in the tryptamine hallucinogens dimethyltryptamine (DMT), which acts as a serotonin 5-HT2A agonist. This mechanism of action is similar to other compounds such as lysergic acid diethylamide (LSD) and psilocybin. The controlled use of LSD and psilocybin in experimental settings is associated with a low incidence of psychotic episodes, and population studies corroborate these findings. Both the controlled use of DMT in experimental settings and the use of ayahuasca in experimental and ritual settings are not usually associated with psychotic episodes, but little is known regarding ayahuasca or DMT use outside these controlled contexts...
April 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28540033/use-of-repeated-intravenous-ketamine-therapy-in-treatment-resistant-bipolar-depression-with-suicidal-behaviour-a-case-report-from-spain
#8
REVIEW
Álvaro López-Díaz, José Luis Fernández-González, José Evaristo Luján-Jiménez, Sara Galiano-Rus, Luis Gutiérrez-Rojas
The rapidly-acting antidepressant properties of ketamine are a trend topic in psychiatry. Despite its robust effects, these are ephemeral and can lead to certain adverse events. For this reason, there is still a general concern around the off-label use of ketamine in clinical practice settings. Nonetheless, for refractory depression, it should be an indication to consider. We report the case of a female patient admitted for several months due to a treatment-resistant depressive bipolar episode with chronic suicidal behaviour...
April 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28348732/probuphine%C3%A2-buprenorphine-implant-a-promising-candidate-in-opioid-dependence
#9
REVIEW
Preeti Barnwal, Saibal Das, Somnath Mondal, Anand Ramasamy, Tanay Maiti, Arunava Saha
Opioid dependence leads to physical dependence and addiction which finally results in profound medical, psychological and social dysfunction. One of the useful medications for opioid dependence is buprenorphine, the partial opioid agonist, which is used alone or in combination with naloxone. However, buprenorphine is the victim of its own success due to its illicit use and accidental poisoning in children. Also, buprenorphine typically requires daily self-administration and its effectiveness heavily depends on patient adherence...
March 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28348731/clonazepam-improves-dopamine-supersensitivity-in-a-schizophrenia-patient-a-case-report
#10
REVIEW
Mina Fukai, Tetsu Hirosawa, Tetsuya Takahashi, Reizo Kaneda, Mitsuru Kikuchi, Yoshio Minabe
Dopamine supersensitivity is an important consideration for assessing treatment-resistant schizophrenia. The emergence of dopamine supersensitivity might be related to upregulation of dopamine D2 receptor, which engenders tolerance to antipsychotics, rebound psychosis, and tardive dyskinesia (TD). A 24-year-old man with a history of treatment-resistant schizophrenia was hospitalized for treatment of bone fracture sustained during a suicide attempt. After the operation, his clinical symptoms implied malignant catatonia...
March 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28348730/prescribing-pattern-of-clozapine-and-other-antipsychotics-for-patients-with-first-episode-psychosis-a-cross-sectional-survey-of-early-intervention-teams
#11
Tongeji E Tungaraza, Wakil Ahmed, Chinonyelum Chira, Erin Turner, Susan Mayaki, Harpal Singh Nandhra, Tom Edwards, Saeed Farooq
OBJECTIVE: To describe the pattern of antipsychotic drug prescribing in patients with first episode psychosis, with more emphasis in the use of clozapine in this group of patients. METHOD: A cross-sectional survey involving six early intervention service (EIS) teams in the West Midlands was conducted. Data was extracted from case notes and electronic records by clinicians working in each participating team. The pattern of antipsychotic prescribing and the changes that took place after being accepted in EIS, including the use of clozapine, was established...
March 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28344764/atypical-antipsychotics-recent-research-findings-and-applications-to-clinical-practice-proceedings-of-a-symposium-presented-at-the-29th-annual-european-college-of-neuropsychopharmacology-congress-19-september-2016-vienna-austria
#12
REVIEW
Robin Murray, Christoph U Correll, Gavin P Reynolds, David Taylor
Available evidence suggests that second-generation atypical antipsychotics are broadly similar to first-generation agents in terms of their efficacy, but may have a more favourable tolerability profile, primarily by being less likely to cause extrapyramidal symptoms. However, atypical antipsychotics are variably associated with disturbances in the cardiometabolic arena, including increased body weight and the development of metabolic syndrome, which may reflect differences in their receptor binding profiles...
March 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28255440/interaction-between-clozapine-and-oxcarbazepine-a-case-report
#13
Hazel Yousra, Lebain Pierrick, Lecardeur Laurent, Debruyne Danièle
No abstract text is available yet for this article.
February 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28255439/case-report-of-a-switch-to-mania-induced-by-lurasidone
#14
Mark Kanzawa, Olga Hadden
No abstract text is available yet for this article.
February 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28255438/lactate-in-the-brain-an-update-on-its-relevance-to-brain-energy-neurons-glia-and-panic-disorder
#15
REVIEW
Laurel Riske, Rejish K Thomas, Glen B Baker, Serdar M Dursun
Lactate is considered an important metabolite in the human body, but there has been considerable debate about its roles in brain function. Research in recent years has suggested that lactate from astrocytes may be crucial for supporting axonal function, especially during times of high metabolic demands or hypoglycemia. The astrocyte-neuron lactate transfer shuttle system serves a protective function to ensure a supply of substrates for brain metabolism, and oligodendrocytes appear to also influence availability of lactate...
February 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28255437/effects-of-a-smoking-ban-on-clozapine-plasma-concentrations-in-a-nonsecure-psychiatric-unit
#16
Siobhan H Gee, David M Taylor, Sukhwinder S Shergill, Robert Flanagan, James H MacCabe
BACKGROUND: Tobacco smoke is known to affect plasma levels of some drugs, including the antipsychotic clozapine. The effects of suddenly stopping smoking on patients who take clozapine can be severe, as plasma concentrations are expected to rapidly rise, potentially leading to toxicity. A ban on smoking at South London and the Maudsley NHS Foundation Trust (SLaM) was implemented in 2014, and this was expected to affect the plasma concentrations of clozapine for inpatients at the time...
February 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28255436/does-the-efficacy-of-asenapine-in-bipolar-disorder-increase-in-the-presence-of-comorbidity-with-a-substance-use-disorder-a-naturalistic-study
#17
Sergio De Filippis, Ilaria Cuomo, Georgios D Kotzalidis, Daniela Pucci, Pietro Zingaretti, Raffaella Porrari, Camilla Fini, Paola Motta, Matteo Caloro, Paolo Girardi
BACKGROUND: Asenapine is a second-generation antipsychotic approved in Europe for treating moderate-to-severe manic episodes in adults affected by type I bipolar disorder (BD-I). We aimed to compare its efficacy in psychiatric inpatients with BD-I, with or without substance use disorder (SUD). METHODS: We administered flexible asenapine doses ranging from 5-20 mg/day to 119 voluntarily hospitalized patients with Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) BD-I diagnosis, with or without SUD...
February 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28255435/the-effect-of-long-acting-paliperidone-palmitate-once-monthly-on-negative-and-depressive-symptoms-in-patients-with-schizophrenia-switched-from-previous-unsuccessful-treatment-with-oral-aripiprazole
#18
Andreas Schreiner, Paul Bergmans, Pierre Cherubin, Ludger Hargarter
BACKGROUND: The negative symptoms of schizophrenia are generally harder to recognize, more difficult to treat than positive symptoms, and have a significant impact on patient functioning and overall outcomes. Treatment with aripiprazole may be associated with benefits on negative symptoms and functioning given its partial agonism to the dopamine D2 receptor. The aim of this subanalysis was to explore the impact of flexibly dosed, long-acting paliperidone palmitate once monthly (PP1M) on negative and depressive symptoms, disorganized thoughts, anxiety, extrapyramidal symptoms, and patient functioning in nonacute adult patients with schizophrenia previously unsuccessfully treated with oral aripiprazole monotherapy...
February 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28101325/role-of-psilocybin-in-the-treatment-of-depression
#19
Ananya Mahapatra, Rishi Gupta
Psilocybin is a naturally occurring alkaloid, pharmacologically similar to the classic hallucinogen lysergic acid diethylamide (LSD). Although primarily used as a recreational drug or an entheogen in particular cultural settings, recent population based studies have shown that it does not lead to serious physical or mental health problems or dependent use. In view of recent work demonstrating psilocybin's potential to increase subjective sense of wellbeing and because of its novel mechanism of 5-HT2A serotonin receptor agonism, it is being explored for possible therapeutic utility in mood and anxiety disorders...
January 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28101324/oxytocin-for-frontotemporal-dementia-a-systematic-review
#20
REVIEW
Rajesh R Tampi, Michael Maksimowski, Mohsina Ahmed, Deena J Tampi
BACKGROUND: The aim of this systematic review is to identify published randomized controlled trials (RCTs) that evaluated the use of oxytocin in individuals with frontotemporal dementia (FTD). METHODS: A literature search was conducted of PubMed, MEDLINE, EMBASE, PsycINFO and Cochrane collaboration databases for RCTs in any language that evaluated the use of oxytocin in individuals with FTD. Bibliographic databases of published articles were also searched for additional studies...
January 2017: Therapeutic Advances in Psychopharmacology
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