Yareni A Ayala, Bruno Pontes, Diney S Ether, Luis B Pires, Glauber R Araujo, Susana Frases, Luciana F Romão, Marcos Farina, Vivaldo Moura-Neto, Nathan B Viana, H Moysés Nussenzveig
BACKGROUND: The viscoelastic properties of cells have been investigated by a variety of techniques. However, the experimental data reported in literature for viscoelastic moduli differ by up to three orders of magnitude. This has been attributed to differences in techniques and models for cell response as well as to the natural variability of cells. RESULTS: In this work we develop and apply a new methodology based on optical tweezers to investigate the rheological behavior of fibroblasts, neurons and astrocytes in the frequency range from 1Hz to 35Hz, determining the storage and loss moduli of their membrane-cortex complex...
2016: BMC Biophysics