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International Journal of Clinical Pharmacy

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https://www.readbyqxmd.com/read/29159520/moral-dilemmas-of-community-pharmacists-a-narrative-study
#1
Martine Kruijtbosch, Wilma Göttgens-Jansen, Annemieke Floor-Schreudering, Evert van Leeuwen, Marcel L Bouvy
Background Pharmacists are increasingly involved in patient care. This new role in a complex healthcare system with demanding patients may lead to moral dilemmas. There has been little research into pharmacy ethics, and existing data are limited by their retrospective nature and small sample sizes. A thematic overview of the moral dilemmas experienced by community pharmacists is still missing. Objective To make a thematic overview of moral dilemmas experienced in daily pharmacy practice. Setting Dutch community pharmacy...
November 20, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29147964/diabetes-care-in-qatar-a-survey-of-pharmacists-activities-attitudes-and-knowledge
#2
Maguy Saffouh El Hajj, Safae E Abu Yousef, Meena Ali Basri
Background Diabetes mellitus is recognized as a major public health issue and is one of the top ten causes of death in Qatar. Objective To describe the activities, and attitudes of Qatar pharmacists toward diabetes, to measure their diabetes knowledge and to assess their perceived barriers for diabetes care. Setting Community and ambulatory pharmacies in Qatar. Method Study objectives were addressed in a cross sectional survey of community and ambulatory pharmacists in Qatar. A phone call explaining the study was made to all community and ambulatory pharmacists in Qatar...
November 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29147963/inappropriate-anticholinergic-drugs-prescriptions-in-older-patients-analysing-a-hospital-database
#3
Laurie Ferret, Gregoire Ficheur, Emeline Delaviez, Michel Luyckx, Sophie Quenton, Regis Beuscart, Emmanuel Chazard, Jean-Baptiste Beuscart
Background Although many anticholinergics are inappropriate in older patients, the prescription of these drugs in a hospital setting has not been extensively studied. Objective To describe prescriptions of anticholinergic drugs in terms of frequency, at risk situations and constipation in hospitalized, older adults. Setting Using a database from a French general hospital (period 2009-2013), we extracted information on 14,090 hospital stays by patients aged 75 and over. Methods Anticholinergic drug prescriptions were automatically detected, with a focus on prescriptions in three well-known at-risk situations: falls, dementia, and benign prostatic hyperplasia...
November 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29147962/retrospective-review-of-ceftriaxone-versus-levofloxacin-for-treatment-of-e-coli-urinary-tract-infections
#4
Samantha S Wang, Patrick D Ratliff, William R Judd
Background Urinary tract infections (UTIs) are among the most common bacterial infections. Options for initial treatment of pyelonephritis or UTI requiring hospitalization include levofloxacin (LVF) or extended-spectrum cephalosporins. Globally, uropathogenic Escherichia coli resistance rates to fluoroquinolones have increased in recent years. Objective To compare clinical outcomes of patients receiving ceftriaxone (CTX) to those who received LVF empirically for the treatment of E. coli UTI. Setting 433-bed community hospital in Lexington, KY...
November 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29134489/the-quick-loss-of-carbapenem-susceptibility-in-pseudomonas-aeruginosa-at-intensive-care-units
#5
Yamin Zou, Jiangping Lian, Ying Di, Haisheng You, Hongping Yao, Junhui Liu, Yalin Dong
Background Patients colonized with carbapenem-susceptible Pseudomonas aeruginosa (CSPA) strains upon admission to the intensive care unit (ICU) tend to be quickly followed by detected carbapenem-resistant P. aeruginosa strains after admission. Objective To assess the risk factors associated with the quick loss of carbapenem susceptibility and to identify time threshold of prior antimicrobial exposure for the loss during ICU stay. Setting A tertiary-care teaching hospital with 2560 beds located in the northwest region of China...
November 14, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29134488/impact-of-clinical-pharmacists-intervention-on-management-of-hyperglycemia-in%C3%A2-pregnancy-in-jordan
#6
Razan Adnan Batta, Violet Kasabri, Amal Akour, Dana Hyassat, Abla Albsoul-Younes
Background and objective Hyperglycemia in pregnancy is a risk factor for cardiovascular disease and postpartum (PP) diabetes. This study aimed to assess the impact of the clinical pharmacist-assisted program (CPAP) of optimizing drug therapy and intensive education on main management outcome measures of patient knowledge about diabetes, Quality of life (QoL) as measured by SF-36 including maternal complications, fasting plasma glucose (FPG) control, and HbA1c. Method This is a randomized controlled study. Pregnant (20-28 weeks) patients with hyperglycemia received CPAP (n = 51) as compared with conventional management (n = 34)...
November 14, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29134487/sildenafil-citrate-use-in-addis-ababa-characteristics-of-users-and-pharmacists-dispensing-practices
#7
Dawit Teshome Gebregeorgise, Yajeb Melesse Belay, Sofia Kälvemark Sporrong
Background Studies have reported misuse of sildenafil citrate for recreational purpose, not least by healthy young men. This is becoming a major concern, for medical and other reasons. Objective The aim of this study was to document the characteristics of sildenafil citrate users and to explore the dispensing practices of the medicine in selected community pharmacies in Addis Ababa, Ethiopia. Setting Data was collected in community pharmacies in Addis Ababa, Ethiopia. Method A survey, using a self-administrated questionnaire, was conducted among customers who purchased sildenafil citrate from community pharmacies...
November 14, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29116462/the%C3%A2-effect-of-partial-patients-adherence-to-antihypertensive-drugs-scope-for-pharmacists-role-in-hypertension-care
#8
Marine Sitbon, Jennifer Corny, Hélène Beaussier, Yvonnick Bézie
In many individuals, blood pressure varies between clinic visits conducted days, weeks, or months apart. This visit-to-visit variability (VVV) of blood pressure has been recently related with an increased risk of coronary heart disease, stroke, and mortality, independently of mean blood pressure. As for other chronical diseases, patients' adherence to hypertensive therapies remains low and partial adherence to antihypertensive treatment may constitute a source of VVV, as suggested by recent studies. This data should lead to a new clinical approach for hypertension care, based on patients' real adherence to treatment...
November 7, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29086147/drug-induced-anaphylaxis-in-china-a-10%C3%A2-year-retrospective-analysis-of-the-beijing-pharmacovigilance-database
#9
Ying Zhao, Shusen Sun, Xiaotong Li, Xiang Ma, Huilin Tang, Lulu Sun, Suodi Zhai, Tiansheng Wang
Background Few studies on the causes of drug-induced anaphylaxis (DIA) in the hospital setting are available. Objective We aimed to use the Beijing Pharmacovigilance Database (BPD) to identify the causes of DIA in Beijing, China. Setting Anaphylactic case reports from the BPD provided by the Beijing Center for Adverse Drug Reaction Monitoring. Method DIA cases collected by the BPD from January 2004 to December 2014 were adjudicated. Cases were analyzed for demographics, causative drugs and route of administration, and clinical signs and outcomes...
October 31, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28871421/biosimilar-uptake-by-british-local-formularies-a-cross-sectional-study
#10
Saja Alnahar, Rachel A Elliott, Murray D Smith
Background Biological medicines are starting to lose their patent protection, so similar, inexact copies (biosimilars) are being developed and licensed. The high acquisition costs of biologics for healthcare providers could be reduced by switching to biosimilars, thus alleviating budgetary pressures and increasing patient access. Therefore, the acceptance of biosimilars by prescribers in Great Britain (GB; England, Scotland, Wales) needs to be described and understood. Objective To determine uptake of the first wave of biosimilars (somatropin, epoetin, filgrastim) by local formularies (lists of preferred medicines for prescribing in local healthcare settings)...
September 4, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29139019/pharmacists-confidence-when-providing-pharmaceutical-care-on-anticoagulants-a-multinational-survey
#11
John Papastergiou, Nadir Kheir, Katerina Ladova, Silas Rydant, Fabio De Rango, Sotiris Antoniou, Reka Viola, Maria Dolores Murillo, Stephane Steurbaut, Filipa Alves da Costa
Background Guidelines on the management of orally anticoagulated patients are continuously evolving, leading to an increased need for pharmacists to be fully integrated in care provision. Objective To identify self-reported gaps in confidence among practicing pharmacists in the area of anticoagulation. Setting Pharmacists in different work settings in different countries. Method Cross-sectional international survey from October 2015 till November 2016 among pharmacists working in different settings to assess their level of confidence when delivering anticoagulants as well as to identify possible educational needs regarding this medication class...
December 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29101617/quality-of-medication-information-in-discharge-summaries-from-hospitals-an-audit-of-electronic-patient-records
#12
Beate Hennie Garcia, Berit Svendsen Djønne, Frode Skjold, Ellen Marie Mellingen, Trine Iversen Aag
Background Low quality of medication information in discharge summaries from hospitals may jeopardize optimal therapy and put the patient at risk for medication errors and adverse drug events. Objective To audit the quality of medication information in discharge summaries and explore factors associated with the quality. Setting Helgelandssykehuset Mo i Rana, a rural hospital in central Norway. Method For each month in 2013, we randomly selected 60 discharge summaries from the Department of Medicine and Surgery (totally 720) and evaluated the medication information using eight Norwegian quality criteria...
December 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29101616/a-multifaceted-intervention-to-reduce-guideline-non-adherence-among-prescribing-physicians-in-dutch-hospitals
#13
Jacqueline M Bos, Stephanie Natsch, Patricia M L A van den Bemt, Johan L W Pot, J Elsbeth Nagtegaal, Andre Wieringa, Gert Jan van der Wilt, Peter A G M De Smet, Cornelis Kramers
Background Despite the potential of clinical practice guidelines to improve patient outcomes, adherence to guidelines by prescribers is inconsistent. Objective The aim of the study was to determine whether an approach of introducing an educational programme for prescribers in the hospital combined with audit and feedback by the hospital pharmacist reduces non-adherence of prescribing physicians to key pharmacotherapeutic guidelines. Setting This prospective intervention study with a before-after design evaluated patients at surgical, urological and orthopaedic wards...
December 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29101615/trough-level-from-twice-daily-to-once-daily-tacrolimus-in-early-conversion-kidney-transplant-recipients-a-prospective-study
#14
Sayamon Sukkha, Busba Chindavijak, Preecha Montakantikul, Atiporn Ingsathit, Wichit Nosoongnoen, Vasant Sumethkul
Background Early conversion from twice-daily tacrolimus (TAC-BID) to once-daily tacrolimus (TAC-OD) provides a greater benefit of reducing under-exposure of TAC-OD during the first period after transplantation. Information regarding the conversion dose among Asian kidney transplant recipients is still limited. Objective This study aimed to compare the trough levels (Cmin) of TAC-BID (Prograf(®)) and TAC-OD (Advagraf(®)). The values were obtained from early conversion intervention by 1:1 milligram per-milligram...
December 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29086146/addressing-the-global-need-for-public-health-clinical-pharmacists-through-student-pharmacist-education-a-focus-on-developing-nations
#15
Miranda G Law, Prosper Maposa, David R Steeb, Gregory Duncan
It is time for pharmacists to begin advancing their roles in public health and play a more integral part in public health initiatives. Within developed nations, the profession has demonstrated its value in advancing preventive care; however, the same cannot be said for pharmacists worldwide. Emphasis on training public health pharmacists should also be on developing nations, where the need for preventive care is highly unmet. To ensure all graduating pharmacists are prepared to engage in public health activities, education in this field must be provided during their main years of pharmacy school...
December 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29086145/exposure-to-anticholinergic-and-sedative-medicines-as-indicators-of-high-risk-prescriptions-in-the-elderly
#16
Elodie Jean-Bart, Claire Moutet, Virginie Dauphinot, Pierre Krolak-Salmon, Christelle Mouchoux
Background There are several assessment scales to evaluate the risk of falls or the adverse drug reaction risk. Few are sufficiently specific to assess the impact of drug prescriptions on falls in geriatric populations. Objective To define the risk of anticholinergic and sedation-related ADRs in an elderly hospitalized patient population using the Drug Burden Index (DBI), Anticholinergic Drug Scale (ADS), and Sedative Load Model (SLM). Setting Five geriatric university hospital centers in France. Method Multicenter prospective cohort study from 2011 to 2013...
December 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29082460/implementation-of-an-it-guided-checklist-to-improve-the-quality-of-medication-history-records-at-hospital-admission
#17
Tanja Huber, Franziska Brinkmann, Silke Lim, Christoph Schröder, Daniel Johannes Stekhoven, Walter Richard Marti, Richard Robert Egger
Background Medication discrepancies often occur at transition of care such as hospital admission and discharge. Obtaining a complete and accurate medication history on admission is essential as further treatment is based on it. Objective The goal of this study was to reduce the proportion of patients with at least one medication discrepancy in the medication history at admission by implementing an IT-guided checklist. Setting Surgery ward focused on vascular and visceral surgery at a Swiss Cantonal Hospital...
December 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29079938/adverse-effects-of-direct-acting-antiviral-based-regimens-in-chronic-hepatitis-c-patients-a-brazilian-experience
#18
Thalia Medeiros, Camila de Morais Salviato, Natalia Fonseca do Rosário, Geórgia do Nascimento Saraiva, Eliane Bordalo Cathalá Esberard, Jorge Reis Almeida, Analúcia Rampazzo Xavier, Andrea Alice da Silva
Background Direct-acting antivirals (DAA) are currently used for the treatment of chronic hepatitis C (HCV). However, few studies describe the adverse effects (AE) associated with DAA therapy in "real-word" cohorts. Aim To evaluate AE in Brazilian chronic HCV patients after DAA-therapy. Setting A reference center for hepatitis treatment in Rio de Janeiro, Brazil. Methods An observational "real-world" study was conducted with 102 chronic HCV patients undergoing DAA therapy for 12 or 24 weeks. The self-reported AE were correlated with cirrhosis status, genotype, age, current therapeutic schemes and comorbidities...
December 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29076013/hospital-staff-views-of-prescribing-and-discharge-communication-before-and-after-electronic-prescribing-system-implementation
#19
Pamela Ruth Mills, Anita Elaine Weidmann, Derek Stewart
Background Electronic prescribing system implementation is recommended to improve patient safety and general practitioner's discharge information communication. There is a paucity of information about hospital staff perspectives before and after system implementation. Objective To explore hospital staff views regarding prescribing and discharge communication systems before and after hospital electronic prescribing and medicines administration (HEPMA) system implementation. Setting A 560 bed United Kingdom district general hospital...
December 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29076012/prescribers-views-and-experiences-of-assessing-the-appropriateness-of-prescribed-medications-in-a-specialist-addiction-service
#20
Adejoke Obirenjeyi Oluyase, Duncan Raistrick, Elizabeth Hughes, Charlie Lloyd
Background Mental and physical health problems are common in people with substance misuse problems and medications are often required in their management. Given the extent of prescribing for service users who attend specialist addiction services, it is important to consider how prescribers in this setting assess the appropriateness of service users' prescribed medications. Objective To explore prescribers' views and experiences of assessing the appropriateness of medications prescribed for service users coming in for treatment as well as the differences between prescribers...
December 2017: International Journal of Clinical Pharmacy
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