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International Journal of Clinical Pharmacy

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https://www.readbyqxmd.com/read/28918483/effects-of-multidisciplinary-teams-and-an-integrated-follow-up-electronic-system-on-clinical-pharmacist-interventions-in-a-cancer-hospital
#1
Muhammad Tahir Aziz, Tofeeq Ur Rehman, Sadia Qureshi, Sidrah Andleeb
Background The aim of drug therapy is to attain distinct therapeutic effects that not only improve patient's quality of life but also reduce the inherent risks associated with the therapeutic use of drugs. Pharmacists play a key role in reducing these risks by developing appropriate interventions. Whether to accept or reject the intervention made by the pharmacist is a relevant consultant's decision. Objective To evaluate the impact of electronic prompts and follow-up of rejected pharmacy interventions by clinical pharmacists in an in-patient setting...
September 16, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28905162/quality-of-prescribing-in-community-dwelling-elderly-patients-in-france-an-observational-study-in-community-pharmacies
#2
E Bourcier, F Mille, V Brunie, V Korb-Savoldelli, C Lafortune, M Buyse, C Fernandez, P Hindlet
Background In order to ensure safer prescriptions in the elderly, lists of potentially inappropriate medications (PIMs) and guidelines have been introduced. Whereas the effectiveness of these measures has been well studied in hospitals, data are sparse for the community-dwelling patients. Objective To assess the quality of prescriptions among community-dwelling elderly patients, and potential associations between prescription patterns, patient characteristics and medication adherence. Setting Community pharmacies in France...
September 14, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28905171/pharmacist-intervention-acceptance-for-the-reduction-of-potentially-inappropriate-drug-prescribing-in-acute-psychiatry
#3
Sophia Hannou, Pierre Voirol, André Pannatier, Marie-Laure Weibel, Farshid Sadeghipour, Armin von Gunten, Jean-Frédéric Mall, Isabella De Giorgi Salamun
Background Prescribing for the elderly is challenging. A previous observational study conducted in our geriatric psychiatry admission unit (GPAU) using STOPP/START criteria showed a high number of potentially inappropriate drug prescriptions (PIDPs). A clinical pharmacist was added to our GPAU as a strategy to reduce PIDPs. Objective The objective of the present study was to assess the impact of a clinical pharmacist on PIDPs by measuring acceptance rates of pharmacist interventions (PhIs). Setting This study was conducted at the GPAU of Lausanne University Hospital...
September 13, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28895028/prevalence-of-qt-interval-prolonging-drug-drug-interactions-qt-ddis-in-psychiatry-wards-of-tertiary-care-hospitals-in-pakistan-a-multicenter-cross-sectional-study
#4
Qasim Khan, Mohammad Ismail, Iqbal Haider, Fahadullah Khan
Background QT prolongation and associated arrhythmias, torsades de pointes (TdP), are considerable negative outcomes of many antipsychotic and antidepressant agents frequently used by psychiatric patients. Objective To identify the prevalence, levels, and predictors of QT prolonging drug-drug interactions (QT-DDIs), and AZCERT (Arizona Center for Education and Research on Therapeutics) classification of drugs involved in QT-DDIs. Setting Psychiatry wards of three major tertiary care hospitals of Khyber-Pakhtunkhwa, Pakistan...
September 12, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28887610/exploring-the-concept-of-patient-centred-communication-for-the-pharmacy-practice
#5
Majanne Wolters, Rolf van Hulten, Lyda Blom, Marcel L Bouvy
Background Patient centred communication can improve pharmaceutical care, but is not well described for pharmacists. Aim of the review To provide a comprehensive and accessible overview of the concept of patient centred communication for the pharmacy practice. Method A scoping review and thematic analysis was undertaken to synthesize the extracted data and present it in a model. Results Literature search and selection resulted in eighteen articles. Thematic analysis of the extracted data led to five categories regarding patient centred communication...
September 9, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28875370/how-prepared-are-pharmacists-to-support-atrial-fibrillation-patients-in-adhering-to-newly-prescribed-oral-anticoagulants
#6
Nadya Hamedi, Filipa Alves da Costa, Robert Horne, Michael Levitan, Amanda Begley, Sotiris Antoniou
Background The New Medicines Service (NMS) was implemented in the United Kingdom in 2011 and first evaluated in 2014, showing 10% increase on adherence. Objective To assess community pharmacists' current practice, knowledge and confidence in supporting patients' adherence as part of the NMS for patients on Oral Anti-Coagulants (OACs) for stroke prevention in Atrial Fibrillation. Setting Community pharmacists in London. Method An online cross-sectional survey was sent to pharmacists from their Local Pharmaceutical Committees and advertised by the Royal Pharmaceutical Society...
September 5, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28871421/biosimilar-uptake-by-british-local-formularies-a-cross-sectional-study
#7
Saja Alnahar, Rachel A Elliott, Murray D Smith
Background Biological medicines are starting to lose their patent protection, so similar, inexact copies (biosimilars) are being developed and licensed. The high acquisition costs of biologics for healthcare providers could be reduced by switching to biosimilars, thus alleviating budgetary pressures and increasing patient access. Therefore, the acceptance of biosimilars by prescribers in Great Britain (GB; England, Scotland, Wales) needs to be described and understood. Objective To determine uptake of the first wave of biosimilars (somatropin, epoetin, filgrastim) by local formularies (lists of preferred medicines for prescribing in local healthcare settings)...
September 4, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28840436/optimising-patient-safety-using-pharmaceutical-intervention-in-domiciliary-hospitalization
#8
Ana Mafalda Brito, Ana Margarida Simões, Armando Alcobia, Filipa Alves da Costa
Introduction The domiciliary hospitalization unit (DHU) is an innovative model of care provision, where hospital care is transferred to the patients' home. However, this shift adds a care transition layer to the process, which may increase the probability of medication errors to occur. Method A pharmacist has been integrated into the DHU team to improve medication use. We developed an observational study documenting his intervention for 6 months. Information about the patient's drug therapy before admission, during hospitalization and after hospital discharge were gathered, enabling comparison of possible discrepancies that may happen during care transitions...
August 23, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28836131/redefining-the-pharmacology-and-pharmacy-subject-category-in-the-journal-citation-reports-using-medical-subject-headings-mesh
#9
Fernando Minguet, Teresa M Salgado, Claudio Santopadre, Fernando Fernandez-Llimos
Background The Journal Citation Reports (JCR) Pharmacology and Pharmacy subject category is heterogeneous. The inclusion of journals with basic and clinical scopes, which have different citation patterns, compromises comparability of impact factors among journals within the category. Objective To subdivide the Pharmacology and Pharmacy category into basic pharmacology, clinical pharmacology, and pharmacy based on the analyses of Medical Subject Headings (MeSH) as a proxy of journals' scopes. Setting JCR. Method All articles, and respective MeSH, published in 2013, 2014, and 2015 in all journals included in the 2014 JCR Pharmacology and Pharmacy category were retrieved from PubMed...
August 23, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28828593/outcomes-of-pharmacist-provided-medication-review-in-collaborative-care-for-adult-singaporeans-receiving-hemodialysis
#10
Bih Yee Chia, McVin Hua Heng Cheen, Xin Yi Gwee, Melissa Mee Yin Chow, Giat Yeng Khee, Wan Chee Ong, Hui Lin Choong, Paik Shia Lim
Background Patients receiving hemodialysis are predisposed to drug related problems (DRPs). While collaborative care (CC) models with pharmacist involvement can reduce DRP occurrence, few have examined its impact on clinical and economic outcomes. Objective To determine whether a CC model with pharmacist-provided medication review can reduce unplanned admissions and healthcare utilization in patients receiving hemodialysis, compared to usual care (UC). Setting Outpatient nephrology clinic of a tertiary hospital in Singapore...
August 21, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28823072/prevalence-and-predictors-of-digoxin-utilization-among-heart-failure-patients-with-reduced-ejection-fraction-in-qatar
#11
Alaa Abdullah Rahhal, Ahmed Awaisu, Kawthar M Tawengi, Safae AbuYousef, Lylia Mekideche
Background Digoxin is a cardiac glycoside that is recommended by clinical practice guidelines to be used in patients with heart failure with reduced ejection fraction (HFrEF) who still have persistent symptoms despite optimal medical therapy. However, this recommendation is based on limited and old trial data. Moreover, pharmacoepidemiologic studies are important in determining the prevalence of digoxin use and factors influencing this. Objective This study aimed to determine the prevalence and the predictors of digoxin utilization among patients with HFrEF with or without atrial fibrillation (AF) in Qatar...
August 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28823070/-what-is-not-written-does-not-exist-the-importance-of-proper-documentation-of-medication-use-history
#12
Carina Carvalho Silvestre, Lincoln Marques Cavalcante Santos, Alfredo Dias de Oliveira-Filho, Divaldo Pereira de Lyra
Medications are perceived as health risk factors, because they might cause damage if used improperly. In this context, an adequate assessment of medication use history should be encouraged, especially in transitions of care to avoid unintended medication discrepancies (UMDs). In a case-controlled study, we investigated potential risk factors for UMDs at hospital admission and found that 150 (42%) of the 358 patients evaluated had one or more UMDs. We were surprised to find that there was no record of a patient and/or relative interview on previous use of medication in 117 medical charts of adult patients (44...
August 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28823049/exploring-the-challenges-for-clinical-pharmacists-in-sudan
#13
Hwaida Elsadig, Marjorie Weiss, Jenny Scott, Raisa Laaksonen
Background Clinical pharmacy practice in hospitals is a new role for pharmacists in Sudan. Pharmacists have to face the challenge of moving from their traditional roles within the pharmacy premises to new roles on the wards with direct contact with patients and other healthcare professionals. Objectives To explore the role and challenges facing the clinical pharmacists of Sudan. Settings Two of the main government hospitals in Sudan and an online survey. Method This study applied a two phase mixed method, a focus group discussion and a survey...
August 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28823020/perceptions-and-behaviors-of-patients-and-pharmacists-towards-generic-drug-substitution-in-lebanon
#14
Shadi Saleh, Clara Abou Samra, Stewart Jleilaty, Joanne Constantin, Nour El Arnaout, Hani Dimassi, Dania Al-Bittar
Background Patients, physicians and pharmacists are key stakeholders in the implementation of generic substitution policies. Objectives To explore Lebanese patients' perceptions and experience, and pharmacists' dispensing patterns towards the newly enacted unified health prescription policy promoting generic substitution. Setting Pharmacies in Beirut, the capital of Lebanon. Methods A cross-sectional design employing self-administered questionnaires to survey a total of 128 patients and 25 pharmacists. Chi square test and multiple logistic regression were performed...
August 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28823018/prevalence-and-nature-of-potential-drug-drug-interactions-among-kidney-transplant-patients-in-a-german-intensive-care-unit
#15
Julia Amkreutz, Alexander Koch, Lukas Buendgens, Anja Muehlfeld, Christian Trautwein, Albrecht Eisert
Background Complex polypharmacotherapy makes kidney transplant patients vulnerable to drug-drug interactions (DDIs). Objective To study prevalence and nature of potential DDIs (pDDIs) in kidney transplant patients. Setting Internal medicine ICU, University Hospital RWTH Aachen. Method In this retrospective observational study, pDDIs were identified in the first week after transplant from 1999 to 2010. Patients aged at least 18 years with prescription of at least two drugs were included. Patients with incomplete data were excluded...
August 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28795285/polypharmacy-and-potential-drug-drug-interactions-in-emergency-department-patients-in-the-caribbean
#16
Darren Dookeeram, Satesh Bidaisee, Joanne F Paul, Paula Nunes, Paula Robertson, Vidya Ramcharitar Maharaj, Ian Sammy
Background Potential Drug-Drug Interactions (DDI) account for many emergency department visits. Polypharmacy, as well as herbal, over-the-counter (OTC) and combination medication may compound this, but these problems are not well researched in low-and-middle-income countries. Objective To compare the incidence of drug-drug interactions and polypharmacy in older and younger patients attending the Emergency Department (ED). Setting The adult ED of a tertiary teaching hospital in Trinidad. Methods A 4 month cross sectional study was conducted, comparing potential DDI in older and younger patients discharged from the ED, as defined using Micromedex 2...
August 9, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28791494/adherence-with-perindopril-therapy-a-pilot-study-using-therapeutic-drug-monitoring-of-perindoprilat-and-an-evaluation-of-the-clearance-estimation
#17
Martin Šíma, Martin Vodička, Věra Marešová, Tomáš Šálek, Radomír Čabala, Ondřej Slanař
Background Although measurement of drug serum levels is an objective direct method for testing compliance, it can be distorted by "white-coat compliance" or by variations in drug elimination. Objective The aim of this prospective study was to evaluate the prevalence of noncompliance with perindopril therapy in adult out-patients using pharmacokinetic simulations. The additional aim was to compare the predictive performance of two glomerular filtration rate markers-creatinine and cystatin C. Setting Department of Cardiology, Tomas Bata Regional Hospital in Zlín, Czech Republic...
August 8, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28780739/levetiracetam-versus-phenytoin-for-seizure-prophylaxis-in-brain-injured-patients-a-systematic-review-and-meta-analysis
#18
Anis Chaari, Alaa Sayed Mohamed, Karim Abdelhakim, Vipin Kauts, William Francis Casey
Background The onset of early and/or late seizures in brain injured patients is associated with worse outcome. So far, phenytoin is the most commonly used antiepileptic drug to prevent seizures in this group of patients. Objective In the current metaanalysis, we aimed to compare the efficacy and safety of phenytoin versus levetiracetam for seizure prophylaxis in brain injured patients. Methods A systematic search was conducted in PubMed and Cochrane Library Database by 2 investigators. Four randomized controlled trials (RCTs) were included (295 patients)...
August 5, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28756580/assessment-of-patients-knowledge-and-practices-regarding-their-medication-use-and-risks-in-lebanon
#19
Elsy Ramia, Rony M Zeenny, Souheil Hallit, Pascale Salameh
Background Patients' knowledge of their medications play a pivotal role in their disease management. Objective Assess the knowledge and practices of Lebanese outpatients regarding their own medication use and risks. Setting Four hundred and sixty community pharmacies across Lebanon. Method It was a cross-sectional study performed from March through May 2016 among Lebanese outpatients, using a self-administered questionnaire. Descriptive statistics were used to calculate all participants' responses. The association between categorical variables were evaluated using Pearson χ(2) test or Fisher's exact test...
July 29, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28756579/evaluation-of-effects-of-an-operational-multidisciplinary-team-on-antibiotic-use-in-the-medium-to-long-term-at-a-french-university-hospital
#20
Béatrice Demoré, Pauline Humbert, Emmanuelle Boschetti, Sibylle Bevilacqua, Isabelle Clerc-Urmès, Thierry May, Céline Pulcini, Nathalie Thilly
Background Antibiotic-resistant bacteria are a major public health problem throughout the world. In 2006, in accordance with the national guidelines for antibiotic use, the CHRU of Nancy created an operational multidisciplinary antibiotic team at one of its sites. In 2011, a cluster-controlled trial showed that the operational multidisciplinary antibiotic team (the intervention) had a favourable short-term effect on antibiotic use and costs. Objective Our objective was to determine whether these effects continued over the medium to long term (that is, 2-7 years after creation of the operational multidisciplinary antibiotic team, 2009-2014)...
July 29, 2017: International Journal of Clinical Pharmacy
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