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International Journal of Clinical Pharmacy

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https://www.readbyqxmd.com/read/30196515/cost-evolution-of-biological-agents-for-the-treatment-of-spondyloarthritis-in-a-tertiary-hospital-influential-factors-in-price
#1
Mariángeles González-Fernández, Elena Villamañán, Inmaculada Jiménez-Nácher, Francisco Moreno, Chamaida Plasencia, Francisco Gaya, Alicia Herrero, Alejandro Balsa
Background Spending on biological agents has risen dramatically due to the high cost of the drugs and the increased prevalence of spondyloarthritis. Objective To evaluate the annual cost per patient and cost for each biological drug for treating patients with spondyloarthritis from 2009 to 2016, and to calculate factors that affect treatment cost, such as optimizing therapies by monitoring drug serum levels, the use of biosimilar-TNF inhibitors, and official discounts or negotiated rebates in biologicals acquired by the pharmacy department...
September 8, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30173307/the-effect-of-ivabradine-therapy-on-heart-failure-patients-with-reduced-ejection-fraction-a-systematic-review-and-meta-analysis
#2
Camila Hartmann, Natasha Ludmila Bosch, Luara de Aragão Miguita, Elise Tierie, Lídia Zytinski, Cristina Pellegrino Baena
Background Ivabradine is currently indicated to lower heart rate in Heart Failure with Reduced Ejection Fraction (HFrEF) patients. However its effect apart from beta-blockers is not clear. Aim of the review To study the additional effect of ivabradine, apart from the effect of beta-blockers, on cardiovascular death, all-cause mortality, hospitalization due to HF and heart rate in HFrEF population. Method Electronic searches were conducted up to June 2016 to include randomized controlled trials where ivabradine was compared to a control group...
September 1, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30167970/evaluation-of-the-effect-of-acetazolamide-versus-mannitol-on-cisplatin-induced-nephrotoxicity-a-pilot-study
#3
Manal El Hamamsy, Noha Kamal, Naglaa Samir Bazan, Mostafa El Haddad
Background Cisplatin-induced nephrotoxicity still occurs despite the intensive hydration approach adapted to prevent its occurrence. Objective Evaluation of the effect of acetazolamide (ACTZ) on minimizing cisplatin-induced nephrotoxicity compared to mannitol when added to hydration regimen. Setting Nasser Institute Cancer Center (NICC), Cairo, Egypt. Method A total of 35 patients planned to receive cisplatin were divided into two groups: 20 patients received mannitol and 15 patients received ACTZ. Both groups received standard hydration measures as well for prevention of cisplatin-induced nephrotoxicity...
August 30, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30167969/relationship-between-adolescents-and-their-parents-attitudes-toward-medicines-and-awareness-of-the-risk-of-medicines
#4
Zuzana Klimaszova, Tomas Fazekas, Magdalena Kuzelova
Background When they reach adolescence, children begin to independently use medicine without their parents' supervision, but parents usually still want to be involved in their drug therapy. Objective The aim of this study was to investigate how parental attitudes and awareness toward medicine relate to adolescents' attitudes and awareness. Setting Twelve secondary schools in different regions of the Slovak Republic. Method Adolescents and parents responded to a questionnaire, and the answers were paired and analysed...
August 30, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30155774/development-and-validation-of-an-ambulatory-care-patient-satisfaction-questionnaire-to-assess-pharmacy-services-in-malaysia
#5
Pauline Siew Mei Lai, Wen Wei Chung, Li Shean Toh, Sajaratulnisah Othman
Background Assessing patient satisfaction regarding a pharmacy ambulatory care service is important as patient satisfaction is a determinant of the viability and sustainability of the service provided. Objective To develop and validate the Ambulatory Care Patient Satisfaction Questionnaire in Malaysia. Setting A public hospital in Malaysia with two outpatient pharmacies. The main outpatient pharmacy has an average waiting time of 1-2 h; whilst PharmCARE (which prepares repeat prescriptions in advance) has an average waiting time of 5-15 min...
August 29, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30155773/evaluation-of-the-impact-of-pharmacist-led-medication-reconciliation-intervention-a-single-centre-pre-post-study-from-ethiopia
#6
Alemayehu B Mekonnen, Andrew J McLachlan, Jo-Anne E Brien, Desalew Mekonnen, Zenahbezu Abay
Background The role of pharmacists in medication reconciliation (MedRec) is highly acknowledged in many developed nations. However, the impact of this strategy has not been well researched in low-and-middle-income countries, including Ethiopia. Objective The aim of this study was to investigate the impact of pharmacist-led MedRec intervention on the incidence of unintentional medication discrepancies in Ethiopia. Setting Emergency department in a tertiary care teaching hospital in Ethiopia. Method A single centre, prospective, pre-post study was conducted on adults (aged 18 years or over) that had been hospitalized for at least 24 h and were taking at least 2 home medications on admission...
August 28, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30155772/correction-to-ginkgo-biloba-extract-egb-761-%C3%A2-versus-pentoxifylline-in-chronic-tinnitus-a-randomized-double-blind-clinical-trial
#7
Klára Procházková, Ivan Šejna, Jan Skutil, Aleš Hahn
The article Ginkgo biloba extract EGb 761® versus pentoxifylline in chronic tinnitus: a randomized, double-blind clinical trial, written by Klára Procházková, Ivan Šejna, Jan Skutil and Aleš Hahn, was originally published electronically on the publisher's internet portal (currently SpringerLink).
August 28, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30136053/filled-prescriptions-of-age-related-contraindicated-drugs-in-children-a-one-year-nationwide-cohort-study-in-the-netherlands
#8
K Cheung, M Teichert, H A Moll, B H Stricker, L E Visser
Background Children are still prescribed age contraindicated drugs, but information about the number and type of these drugs dispensed for children in the Netherlands is limited. Objective To determine the incidence and prevalence of contraindicated drugs that were dispensed for the use by children. Setting The study was conducted in the Netherlands with routinely collected data from 95% of all community pharmacies. Method We performed a one-year nationwide observational study where all patients aged 17 years or younger who have received at least one prescription in 2016 were included...
August 23, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30132235/psychotropic-drug-use-and-cognitive-rehabilitation-practice-for-elderly-patients
#9
Eiji Kose, Toshiyuki Hirai, Toshiichi Seki
Background Psychotropic drugs were associated with greater risks of adverse drug reactions, including lower the level of consciousness, cause cognitive dysfunction, relax muscles, cause hypotension and others. However, the effect of psychotropic drug use on rehabilitation outcomes is poorly documented in Japan. Objective To assess the association of increased psychotropic drugs during hospitalization with activities of daily living among elderly patients. Setting This study was conducted at the convalescent rehabilitation ward in the Hitachinaka General Hospital in Japan...
August 21, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30117081/pharmacodynamic-model-for-%C3%AE-lactam-regimens-used-in-surgical-prophylaxis-model-based-evaluation-of-standard-dosing-regimens
#10
XiangQing Song, MingHui Long
Background Continual evolution of resistance among bacteria against methods of surgical prophylaxis may make currently used beta-lactam regimens inadequate. Objective To re-evaluate beta-lactam regimens in surgical prophylaxis. Setting A pharmacodynamic Monte Carlo simulation (MCS) model based on a number of patients in China. Methods Pharmacodynamic profiling using Monte Carlo simulation up to 4 hours postinfusion was conducted for standard-dose, short-term (0.5 h) and prolonged (2 to 4 h) infusions of ampicillin, cefazolin, cefotaxime, cefoxitin, cefuroxime, ertapenem, and piperacillin/tazobactam in adult patients with normal renal function...
August 16, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30117080/cost-effectiveness-analysis-of-low-versus-high-dose-colistin-in-the-treatment-of-multi-drug-resistant-pneumonia-in-saudi-arabia
#11
Abdul Karim Suleman Cara, Syed Tabish Razi Zaidi, Fatima Suleman
Background Gram negative pathogens are increasingly resistant to commonly used first line antibiotics and colistin is in most cases the only medicine available. There is very limited information available comparing the effectiveness and costs of low versus high dose colistin with studies showing efficacy with both doses and with variable levels of adverse effects. The absence of a definite dosing strategy makes a model to compare low dose and high dose colistin invaluable in making decisions regarding the appropriate use of colistin...
August 16, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30099664/pharmadhere-training-german-community-pharmacists-with-objective-structured-clinical-examinations
#12
Anna Laven, Maira Anna Deters, Olaf Rose, Holger Schwender, Alexandra Smaranda, Isabell Waltering, Stephanie Laeer
Background Pharmacists who engage in Pharmaceutical Care need skills to optimise responsible medication use and increase medication adherence. Objectives We developed and evaluated a blended-learning programme for German community pharmacists that focused on conducting consultations in chronic diseases. Setting Community pharmacists in Germany. Method Interventional study with pre-post design. We combined e-learning with Objective Standardised Clinical Examinations (OSCEs) for emergency situations, initiation/implementation of medication therapy and detection of symptoms of four chronic diseases...
August 11, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30097820/exploratory-analysis-for-the-implementation-of-antineoplastic-logarithmic-dose-banding
#13
A Albert-Marí, S Valero-García, V Fornés-Ferrer, J L Poveda-Andrés
Background Dose banding (DB) is a strategy to rationalise antineoplastic production at Hospital Pharmacy Aseptic Compounding Units (ACUs) and to reduce patient's waiting time. DB allows for optimizing workflows and workloads, facilitating adoption of new technologies, and increasing safety, quality and efficiency of the compounding process. Objective To evaluate the potential impact of implementation of Logarithmic DB and to identify antineoplastic agents and preparations that fulfil criteria published and establish the number and standard doses that could be compounded in advance at the ACU...
August 10, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30078173/a-practical-approach-toward-teaching-ethics-to-community-pharmacists
#14
Pui San Saw, Lay Hong Chuah, Shaun Wen Huey Lee
Background Pharmacists as highly qualified professionals face ethical dilemmas and conflicts in their daily practice. These issues manifest themselves in the daily practice of pharmacists, which require pharmacists to have the competencies to manage these dilemmas but there is limited formal training in ethical decision making during undergraduate pharmacy education. Objective To describe the implementation and evaluation of a methodological approach to managing ethical dilemma workshop for community pharmacists in Malaysia...
August 4, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30073611/pcne-definition-of-medication-review-reaching-agreement
#15
Nina Griese-Mammen, Kurt E Hersberger, Markus Messerli, Saija Leikola, Nejc Horvat, J W Foppe van Mil, Mitja Kos
Background Medication review is important in an era, in which polypharmacy is increasing. To date, no agreed international definition of medication review exists. Objective The aim was to reach agreement on an internationally applicable definition of medication review. Setting An international group of experts in medication review. Methods A working group of the Pharmaceutical Care Network Europe (PCNE) was established to agree on a definition including a classification of medication review. First, a survey with the aim of systematically gathering viewpoints on a definition of medication review was conducted...
August 2, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30069668/perceptions-and-current-practices-of-community-pharmacists-regarding-antimicrobial-stewardship-in-tasmania
#16
Tasneem Rizvi, Angus Thompson, Mackenzie Williams, Syed Tabish Razi Zaidi
Background Despite increasing interest in antimicrobial stewardship (AMS), little is known about the related practices and perceptions of community pharmacists. Objective To develop and validate a questionnaire to measure the current practices of, and barriers to community pharmacists' participation in AMS. Setting Community pharmacists in Tasmania, Australia. Method A questionnaire to explore AMS knowledge, current practices and perceptions of community pharmacists was developed. It was designed after rigorous literature review, expert opinion, and feedback from a group of community pharmacists...
August 2, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30056568/exploring-medicines-management-by-copd-patients-and-their-social-networks-after-hospital-discharge
#17
Ellen Ingrid Schafheutle, Tom Fegan, Darren M Ashcroft
Background Unplanned hospital admissions (UHAs) for chronic obstructive pulmonary disease (COPD) are a major burden on health services. Effective medicines management is crucial to avoid such admissions but little is known about the role of social networks in supporting medicines-taking. Objective To examine the activities and strategies recently discharged COPD patients and their social network members (SNMs) utilise to manage their medicines. Setting COPD patients recently discharged from an acute NHS Trust in Northwest England...
July 28, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30054787/antimicrobial-use-and-drug-drug-interactions-among-nursing-home-residents-in-singapore-a-multicentre-prevalence-study
#18
Aysu Selcuk, Christine B Teng, Sui Yung Chan, Kai Zhen Yap
Background With the Ministry of Health's projected increase in nursing home beds and optimization of antimicrobial use in health care settings, it is therefore timely to consider baseline prevalence and patterns of antimicrobial use at nursing homes in Singapore as well as to evaluate the prevalence of potential clinically significant drug-drug interactions involving antimicrobials. Objective The primary objective was to determine the prevalence and patterns of antimicrobial use at nursing homes in Singapore...
July 27, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30054786/utilization-of-surgical-antibiotic-prophylaxis-for-obstetrics-and-gynaecology-surgeries-in-northern-nigeria
#19
U Abubakar, S A Syed Sulaiman, A G Adesiyun
Background Audit of antibiotic prophylaxis is an important strategy used to identify areas where stewardship interventions are required. Objectives To evaluate compliance with surgical antibiotic prophylaxis in obstetrics and gynaecology surgeries and determine the Defined Daily Dose (DDD) of antibiotic. Settings Three public tertiary hospitals located in Northern Nigeria. Methods This prospective study included women who had obstetrics and gynaecology surgeries with no infection at the time of incision. Appropriateness of antibiotic prophylaxis was determined by a clinical pharmacist...
July 27, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30051232/inadequate-antibiotic-dosing-in-patients-receiving-sustained-low-efficiency-dialysis
#20
Leigh Anne Keough, Amy Krauss, Joanna Q Hudson
Background Patients requiring SLED are often critically ill and/or hemodynamically unstable, and often need antibiotic therapy for life-threatening infections. Antibiotic dosing recommendations for intermittent hemodialysis and continuous renal replacement therapy are not appropriate for SLED and there is substantial concern for under dosing. Objective To characterize the adequacy of antibiotic dosing during SLED. SETTING: Inpatient adult acute care hospital. Methods A retrospective chart review was performed for the period of October 2010 to August 2013 to identify patients who received SLED and at least one of the selected antibiotics: cefepime, daptomycin, piperacillin/tazobactam, meropenem, and vancomycin...
July 26, 2018: International Journal of Clinical Pharmacy
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