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International Journal of Clinical Pharmacy

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https://www.readbyqxmd.com/read/30006734/current-trends-in-pharmacovigilance-value-and-gaps-of-patient-reporting
#1
Pedro Inácio, Afonso Cavaco, Marja Airaksinen
No abstract text is available yet for this article.
July 13, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29987659/the-social-value-of-pharmaceutical-interventions-the-portuguese-contribution-to-sustainable-development
#2
Filipa A Costa, Sofia Crisóstomo, Ema Paulino, Ana Paula Martins
This commentary focuses on a description of solidarity initiatives developed by pharmacists in different practice areas. These are varied initiatives which contribute to improve the life of human beings in a wide range of formats with one common vector, the pharmacist's involvement. Each of the initiatives described is related to the sustainable development goal it contributes to, whilst also referring to its link to international health policy documents, mostly issued by FIP. We expect this commentary further contributes to boost such initiatives in other parts of the world...
July 10, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29987512/a-qualitative-study-of-the-perspectives-of-older-people-in-remote-scotland-on-accessibility-to-healthcare-medicines-and-medicines-taking
#3
Derek Stewart, Kathrine Gibson-Smith, Scott Cunningham, Sharon Pfleger, Gordon Rushworth
Background Recent evidence highlights the disproportionate rates of health inequality often experienced within remote and rural communities. Access to medicines within remote and rural communities may also prove problematic. Objective The aim was to understand the perspectives of older people in the most remote areas of the Scottish Highlands on issues of accessibility to healthcare, medicines and medicines-taking. Method Qualitative, semi-structured one-to-one interviews with 13 residents aged 65 years and over in the most remote and rural areas of the Scottish Highlands...
July 9, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29987511/the-association-between-polypharmacy-and-medication-regimen-complexity-and-antibiotic-use-in-bronchiectasis
#4
Maureen Spargo, Cristín Ryan, Damian Downey, Carmel Hughes
Background Polypharmacy is associated with an increased risk of adverse drug events, inappropriate prescribing and medication errors. People with bronchiectasis have frequent pulmonary exacerbations that require antibiotic therapy. Objective This study aimed to measure polypharmacy and medication regimen complexity in bronchiectasis patients and to explore associations between these factors and oral and intravenous (IV) antibiotic use for suspected pulmonary exacerbations. Setting Patients were sampled from the Regional Bronchiectasis Clinic at the Belfast Health and Social Care Trust, Northern Ireland...
July 9, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29967966/a-simulated-patient-study-assessing-over-the-counter-supply-and-counseling-in-jordan-responding-to-headache-complaints
#5
Eman A Hammad, Eman Elayeh, Razan Tubeileh, Margaret Watson, Mayyada Wazaify
Background Community pharmacists are the most accessible health professionals for patients seeking advice on minor ailments and over the counter supply. Objectives To assess the management of patients seeking advice for headache in community pharmacies in Jordan. Method A cross-sectional study was conducted using simulated patient in three cities in Jordan. A trained simulated patient enacted an advice-seeking scenario for the treatment of a headache. The visits were evaluated using pre-defined criteria relating to content and communication skills...
July 2, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29956135/esophageal-perforation-a-research-review-of-the-anti-infective-treatment
#6
Jennifer Gregory, Jason Hecht
Background Esophageal perforation is a complex disease state and often difficult to diagnose due to the variability in patient presentation. The chosen anti-infective treatment and duration of anti-infective therapy that patients with esophageal perforation receive has been inconsistent. Choice of anti-infective treatment and duration of therapy may also be highly variable from institution to institution, and can even vary by provider. To our knowledge, there has not been a publication reviewing esophageal perforation with a specific focus on pharmacologic management...
June 28, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29956134/outcomes-of-warfarin-therapy-managed-by-pharmacists-via-hospital-anticoagulation-clinic-versus-online-anticoagulation-clinic
#7
Hua Cao, Jianmei Wu, Jinhua Zhang
Background In response to the recognized difficulty in the management of patients on anticoagulation therapy, anticoagulation management services were developed in both hospital anticoagulation clinics (HACs) and an online anticoagulation clinic (OAC) by a pharmacist. Objective To compare monitoring outcomes and complications of warfarin therapy managed by pharmacists via hospital or on-line. Setting The anticoagulation clinic of Fujian Medical University Union Hospital, China. Method A retrospective, observational cohort study was used to compare patients managed via hospital  to those managed o-line between December 2015 and 2016...
June 28, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29956133/quantifying-the-medication-burden-of-kidney-transplant-recipients-in-the-first-year-post-transplantation
#8
Jac Kee Low, Kimberley Crawford, Elizabeth Manias, Allison Williams
Background Kidney transplantation is an effective treatment, but it is not a cure. Since the risk of graft rejection and the presence of comorbid conditions remain for a lifetime, medications are necessary. Objective To examine the prescription medication burden of adult kidney transplant recipients from 3- to 12-months post-transplantation. Setting All five adult kidney transplant units in Victoria, Australia. Method As part of a larger intervention study, we conducet a retrospective review of prescription refill records and medical records containing the history of medication changes of 64 participants who completed the study was undertaken...
June 28, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29936642/community-pharmacists-attitudes-and-opinions-towards-supplying-clozapine
#9
Yuh-Lin Gan, Claire L O'Reilly
Background Clozapine is very effective for treatment-resistant schizophrenia, but its use has been limited due to the risk of agranulocytosis. From July 2015, clozapine has been accessible from Australian community pharmacies following regulatory changes, but pharmacists' attitudes towards these changes remain unknown. Objective To explore pharmacists' perspectives and experiences in supplying clozapine. Setting Australian community pharmacists. Methods A cross-sectional study with a mixed methods approach involving two phases...
June 23, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29926257/deprescribing-admission-medication-at-a-uk-teaching-hospital-a-report-on-quantity-and-nature-of-activity
#10
Sion Scott, Allan Clark, Carol Farrow, Helen May, Martyn Patel, Michael James Twigg, David John Wright, Debi Bhattacharya
Background Deprescribing medication may be in response to an adverse clinical trigger (reactive) or if future gains are unlikely to outweigh future harms (proactive). A hospital admission may present an opportunity for deprescribing, however current practice is poorly understood. Objective To quantify and describe the nature of deprescribing in a UK teaching hospital. Method Prescribing and discontinuation data for admission medication from a hospital's electronic prescribing system were extracted over 4 weeks...
June 20, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29926256/pharmacist-views-and-pharmacy-capacity-to-deliver-professional-services-in-the-united-arab-emirates
#11
Hamzah Alzubaidi, Ward Saidawi, Kevin Mc Namara
Background The benefits of professional pharmacy services in improving patient outcomes and reducing health expenditure are well documented. To a large extent, these services are not implemented in many developing countries. Objective To explore pharmacists' perceptions of and willingness to provide professional services in the United Arab Emirates (UAE) and the perceived barriers and facilitators. The current provision of pharmacy-based services and capacity for service delivery were also explored. Setting Community pharmacies in Sharjah and Dubai in the UAE...
June 20, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29922968/clinical-pharmacist-interventions-in-managing-drug-related-problems-in-hospitalized-patients-with-neurological-diseases
#12
Mostafa A Sayed Ali, Eman Mohamed Hussein Khedr, Fatma Alzahraa Hassan Ahmed, Nada Nasr Eldin Mohamed
Background Drug-related problems (DRPs) are common in hospitalized patients with neurological diseases. Clinical pharmacy services could minimize drug-related harm and improve patient care. Objective To identify common DRPs in neurology and document clinical pharmacists' medication-related interventions. Setting The wards and intensive care unit of the Department of Neurology at Assiut University Hospital. Method Prospective study of clinical pharmacists' interventions during the routine care work of reviewing patients medical charts over a period of 6 months from January to June 2017...
June 19, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29909563/community-pharmacists-perspectives-on-implementation-of-medicines-use-review-in-slovenia
#13
Urska Nabergoj Makovec, Mitja Kos, Nina Pisk
Background In December 2014 Slovene Chamber of Pharmacies defined procedures for Medicines Use Review (MUR) in Slovenia, together with an educational program and certification to ensure pharmacists' competency to perform MUR. The first 15 pharmacists were certified in June 2015 and implemented the service in their practices. Objective This study aimed to understand the implementation of MUR from the perspectives of the first community pharmacists providing the service in practice. Methods A focus group with first MUR providers took place in February 2016, 6 months after the first pharmacists were certified to provide MUR service...
June 16, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29909562/reporting-adverse-drug-reactions-contribution-knowledge-and-perception-of-german-pharmacy-professionals
#14
Anna Laven, Katharina Schmitz, Wilhelm-Hubertus Franzen
Background The detection, assessment and prevention of adverse drug reactions along the product's life cycle is known as pharmacovigilance. German pharmacists are obliged by law to conduct pharmacovigilance measures, a specific training is not required. Objectives To assess the knowledge, contribution and perception of German pharmacy professionals regarding pharmacovigilance activities, in order to identify their needs to report better on the issue. Setting A semi-quantitative survey among German pharmacy professionals was conducted in November 2017...
June 16, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29948744/learning-the-effects-of-psychotropic-drugs-during-pregnancy-using-real-world-safety-data-a-paradigm-shift-toward-modern-pharmacovigilance
#15
Angela Lupattelli, Olav Spigset, Hedvig Nordeng
The growing evidence on psychotropic drug safety in pregnancy has been possible thanks to the increasing availability of real-world data, i.e. data not collected in conventional randomised controlled trials. Use of these data is a key to establish psychotropic drug effects on foetal, child, and maternal health. Despite the inherent limitations and pitfalls of observational data, these can still be informative after a critical appraisal of the collective body of evidence has been done. By valuing real-world safety data, and making these a larger part of the regulatory decision-making process, we move toward a modern pregnancy pharmacovigilance...
June 15, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29948743/an-historical-overview-over-pharmacovigilance
#16
Giulia Fornasier, Sara Francescon, Roberto Leone, Paolo Baldo
Pharmacovigilance started about 170 years ago, although it was not yet named as such at that time. It is structured activity in the professional health field, with important social and commercial implications aimed at monitoring the risk/benefit ratio of drugs, improving patient's safety and the quality of life. In this commentary we report the milestones of pharmacovigilance up to the present day, in order to understand all the steps that have characterized the historical evolution; from the first reports, which were essentially letters or warnings sent by clinicians to publishers of important and famous scientific journals, up to today's modern and ultra-structured electronic registries...
June 15, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29948742/appropriateness-of-vancomycin-therapeutic-drug-monitoring-and-its-outcomes-among-non-dialysis-patients-in-a-tertiary-hospital-in-singapore
#17
Jun Jie Benjamin Seng, Mei Hui Amanda Yong, Zi Xin Peh, Jie Lin Soong, Mooi Heong Tan
Background Vancomycin therapeutic drug monitoring (TDM) is commonly performed to ensure safe and effective use of the antibiotic. Aim of Study To evaluate appropriateness of vancomycin TDM and its outcomes in Singapore General Hospital. Method A retrospective, cross-sectional study was conducted between 1 January 2014 and 28 February 2014 involving patients who received ≥ 1 dose of intravenous vancomycin with TDM. Patient demographics and relevant vancomycin TDM data were collected from medical records...
June 12, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29948741/outcome-effects-of-antiretroviral-drug-combinations-in-hiv-positive-patients-with-chemotherapy-for-lymphoma-a-retrospective-analysis
#18
F Sombogaard, E J F Franssen, W E Terpstra, E D Kerver, G E L van den Berk, M Crul
Background The combination of combined active antiretroviral therapy (cART) with chemotherapy in the treatment of lymphoma in human immunodeficiency virus (HIV)-positive patients has improved the overall survival of these patients. However, drug-drug interactions between antineoplastic agents and the antiretroviral agents non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs) can occur by influencing the activity of the CYP3A4 enzyme. So far, little is known about the clinical relevance of this interaction: the effect on the efficacy and toxicity of the chemotherapy...
June 12, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29881908/assessment-of-polypharmacy-in-elderly-patients-by-using-data-from-dispensed-medications-in-community-pharmacies-analysis-of-results-by-using-different-methods-of-estimation
#19
Luciana Carla Chiapella, Jorgelina Montemarani Menna, María Eugenia Mamprin
Background Estimating the prevalence of polypharmacy is essential for the evaluation of public health. Many different methodologies are used to determine the number of drugs used by a patient. Objective To analyse and compare three different methods (simultaneous, cumulative and continuous medication) to determine the number of drugs used by a patient, to estimate the prevalence of polypharmacy and to evaluate the possible association between polypharmacy and the gender and age of patients. Method Cross-sectional observational study carried out between April and September 2015...
June 7, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29872960/unintentional-and-intentional-non-adherence-to-immunosuppressive-medications-in-renal-transplant-recipients
#20
Konstadina Griva, Hui Ling Michelle Neo, Anantharaman Vathsala
Background Non-adherence to immunosuppressive medications following renal transplantation is a risk factor for rejection and graft loss. Despite the dire consequences, adherence lapses, both unintentional and intentional, are common and poorly understood. Objective The present study sets to compare the rates and determinants of unintentional, intentional and overall self-reported non-adherence. Setting Outpatient clinic at the National University Centre for Organ Transplantation, Singapore. Method This was a cross-sectional survey administered to N = 152 renal transplant recipients...
June 6, 2018: International Journal of Clinical Pharmacy
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