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International Journal of Clinical Pharmacy

Tiffany K Pon, Natalie Wessel, Vincent Cagonot, Ronnie Delmonte, Denise Roach, Laurel Finta
Background Pregnancy-related venous thromboembolism (VTE) is a leading preventable cause of maternal mortality in the United States; however, American guidelines for pharmacologic VTE prophylaxis remain less aggressive than other developed countries. The Safe Motherhood Initiative (SMI) combines aspects of American and international guidelines to increase utilization of prophylaxis and thereby decrease incidence of pregnancy-related VTE. Objectives To evaluate the prescribing and administration rates of pharmacologic VTE prophylaxis for women undergoing cesarean section (c-section) when retrospectively applying the SMI recommendations...
January 19, 2019: International Journal of Clinical Pharmacy
Lama H Nazer, Jennifer Le
No abstract text is available yet for this article.
January 19, 2019: International Journal of Clinical Pharmacy
Nashmil Ghadimi, Sara Kaveh, Hossein Shabaninejad, Alaadine Lijassi, Ali Zahed Mehr, Hossein Hosseinifard
Background Patients with mitral valve stenosis have increased heart rate. HR reduction is known as an important treatment and therapy strategy for patients with mitral valve stenosis. Aim of the review The aim of this systematic review and meta-analysis was to compare the efficacy of ivabradine versus beta-blockers in patients with mitral stenosis in sinus rhythm. Methods Randomized controlled trials were searched in Cochrane Library, PubMed, Web of Science, CRD, Scopus, and Google Scholar with no start time limitation and ending June 2018...
January 18, 2019: International Journal of Clinical Pharmacy
Nagham Ailabouni, Dee Mangin, Prasad S Nishtala
Background Prolonged use of anticholinergic and sedative medicines is correlated with worsening cognition and physical function decline. Deprescribing is a proposed intervention that can help to minimise polypharmacy whilst potentially improving several health outcomes in older people. Objective This study aimed to examine the feasibility of implementing a deprescribing intervention that utilises a patient-centred pharmacist-led intervention model; in order to address major deprescribing challenges such as general practitioner time constraints and lack of accessible deprescribing guidelines and processes...
January 18, 2019: International Journal of Clinical Pharmacy
Vibhu Paudyal, Kathrine Gibson Smith, Katie MacLure, Katrina Forbes-McKay, Andrew Radley, Derek Stewart
Background Community pharmacists can be an accessible source for advice and support for the people who are homeless, given their utilisation of a variety of currently available services such as dispensing of medicines, drugs and alcohol services. Objective To determine community pharmacists' training, experiences and behavioural determinants in counselling and management of homeless population. Setting UK community pharmacies. Method A questionnaire based on literature and theoretical domains framework was mailed to randomly sampled community pharmacies in England and Scotland (n = 2000)...
January 18, 2019: International Journal of Clinical Pharmacy
Christopher R Kiss, Jillian S Y Lau, Alex Yeung, Ian Woolley
Background In Australia, it is not known how much antibiotic prescribing by infectious diseases physicians is long-term, or how confident they are with the evidence behind this practice. Objective Survey Australian infectious diseases physicians to assess attitudes and prescribing practice prescribing prolonged courses of antibiotics. Methods An online questionnaire was distributed to the mailing group for the Australian Society of Infectious Diseases. Responses were collected from 29th October to 12th November 2015...
January 17, 2019: International Journal of Clinical Pharmacy
Basim M Ayesh, Ibrahim R Al-Astal, Maged M Yassin
BackgroundCYP2C19 loss-of-function polymorphic alleles (*2 and *3) have been documented to impair clopidogrel metabolism, and represent a risk factor for major adverse cardiac events. CYP2C19 polymorphism exhibits marked ethnic heterogeneity. Objective To determine the prevalence of CYP2C19 *2 and *3 alleles in a cohort of Palestinian patients managed with percutaneous coronary intervention and dual antiplatelet therapy, and to determine their role in causing major adverse cardiac events. Setting The blood samples were collected at the European Gaza Hospital, and the molecular techniques performed at the molecular genetics laboratory of the Islamic university of Gaza...
January 17, 2019: International Journal of Clinical Pharmacy
Can Qu, Long Meng, Ning Wang, Yong Chen, Xiao Yang, Jun Wang, Shusen Sun, Feng Qiu
Background Data is lacking on types and severities of drug-related problems (DRPs) in hospitalized surgical patients in China. Objective To identify and categorize types and causes of DRPs, and to assess severities of these DRPs. Setting An academic teaching hospital in Chongqing, China. Method We retrospectively reviewed all medication orders for patients in six surgical departments during a six-month period. DRPs were classified using the Pharmaceutical Care Network Europe (PCNE) classification, and the severity ratings of these DRPs were based on the National Coordinating Council for Medication Error Reporting and Prevention (NCCMERP) classification...
January 4, 2019: International Journal of Clinical Pharmacy
Sara Kaveh, Parvin Ebrahimi, Aziz Rezapour, Masoud Mozafari, Kourosh Sayehmiri
Background Improving the survival of patients diagnosed with metastatic colorectal cancer requires the use of chemotherapy to be managed with minimum adverse effects. Randomized control trials (RCTs) have shown promising results with a combination of bevacizumab and erlotinib to block two important tumor growth pathways, namely vascular endothelial growth factor and epidermal growth factor receptor. Aim of the Review We aimed to examine the efficacy and safety of the combination of bevacizumab and erlotinib with bevacizumab alone in the maintenance treatment of metastatic colorectal cancer, by examining PFS, OS, overall response rate (ORR), and toxicity...
January 4, 2019: International Journal of Clinical Pharmacy
Molly Rincavage, Lisa Hammond, Shalini Reddy, Christine Sytsma, Amanda Prater, Marcia Brackbill
Background Despite a trend towards minimally invasive thoracic surgeries over thoracotomies, patients can still experience significant post-operative pain. Literature on the use of liposomal bupivacaine in patients undergoing robotic surgeries is lacking. Objective To compare pain control via intercostal nerve block with liposomal bupivacaine to bupivacaine for patients undergoing robotic assisted thoracic surgery. Setting A 455 bed community hospital. Methods This was a prospective observational study with a historical control group of 96 patients who underwent robotic lung resection...
January 4, 2019: International Journal of Clinical Pharmacy
Sule Ajibola Saka, Frasia Oosthuizen, Manimbulu Nlooto
Background Potential inappropriate prescribing (PIP) among older persons is a global public health issue. However, trans-country data that can influence interventions on a global or regional level is scarce. Objectives To compare the prevalence of PIP and to determine the associated factors among older Nigerians and South Africans. Settings Nigerian and South African teaching hospitals. Method A retrospective evaluation of randomly selected medical charts of older persons was carried out in outpatient clinics of one University teaching hospital in both Nigeria and South Africa...
January 4, 2019: International Journal of Clinical Pharmacy
A Chastang, S Renet, J Corny, H Beaussier, A Petre, A Lillo-Lelouet, T T Phan Thi, Y Bézie
Background Citalopram and escitalopram can both induce dose-dependent QT prolongation. The risk of arrhythmia may be increased with concomitant use of other drugs that induce QT prolongation. Objective To evaluate the prevalence and impact of pharmacist interventions on the combination of citalopram or escitalopram with other drugs that induce QT prolongation. Setting A French hospital with 517 computerized beds. Method All cardiac adverse drug reactions (ADRs) related to citalopram or escitalopram reported to the French pharmacovigilance database (FPDB) were analyzed...
January 4, 2019: International Journal of Clinical Pharmacy
L Pescitelli, L Lazzeri, A Di Cesare, L Tripo, F Ricceri, F Prignano
Background After the expiry of the patent of reference etanercept, several biosimilars have been developed, including SB4. Objective To study safety and efficacy of SB4 in psoriatic patients previously treated with etanercept and in the etanercept naive ones. Method Patients affected by moderate to severe psoriasis and/or psoriatic arthritis attending the Psoriasis Center of Florence University, treated with SB4 were enrolled in the study. Patients were divided in two cohorts. Cohort 1 included 32 patients who were switched from previous etanercept, cohort 2 included 12 patients who were naive to etanercept...
January 4, 2019: International Journal of Clinical Pharmacy
B Bullock, P Donovan, C Mitchell, J A Whitty, I Coombes
Background Medication communication and prescribing on the post-take ward round following patient admission to hospital can be suboptimal leading to worse patient outcomes. Objective To evaluate the impact of clinical pharmacist participation on the post-take ward round on the appropriateness of medication prescribing, medication communication, and overall patient health care outcomes. Setting Tertiary referral teaching hospital, Brisbane, Australia. Method A pre-post intervention study was undertaken that compared the addition of a senior clinical pharmacist attending the post-take ward was compared to usual wardbase pharmacist service, with no pharmacist present of the post-take ward round...
January 4, 2019: International Journal of Clinical Pharmacy
Mayyada Wazaify, Leen Abushams, Marie Claire Van Hout
Several prescription and nonprescription drugs are liable for abuse. However, oral hypoglycemic agents are among the most benign and low-risk drugs in terms of abuse liability. This commentary intends to raise awareness regarding the abuse of a particular type of oral hypoglycemic agent, namely sulfonylurea drugs, used to experience mental-altering effects for its euphoric "hypoglycemic rush." Information is available on discussion fora online where people exchange their experiences. Moreover, several case reports have been published and described the liability for abuse of sulfonylurea drugs...
January 4, 2019: International Journal of Clinical Pharmacy
M Koubaity, M Lelubre, G Sansterre, K Amighi, C De Vriese
Background Many tools exist to document drug-related problems (DRP), such as the Pharmaceutical Care Network Europe (PCNE) classification. However, none have been adapted and published for French-speaking Belgian community pharmacies. Settings French-speaking Belgian Community pharmacies. Objective The objective was to translate and adapt the PCNE V6.2 classification to the Belgian pharmacy practice and legal setting and to assess the content validity, daily use and inter-rater reliability of this classification...
January 4, 2019: International Journal of Clinical Pharmacy
Thomas G H Kempen, Mariann Hedström, Hanna Olsson, Amanda Johansson, Sara Ottosson, Yousif Al-Sammak, Ulrika Gillespie
Background Medication-related hospital admissions (MRAs) are frequently used to measure outcomes in studies involving medication reviews. The process of identifying MRAs is subjective and time-consuming, and practical, validated alternatives are required. Objective The aim of this study was to develop and validate a practical tool to identify MRAs. Setting Uppsala University Hospital, Sweden. Method We reviewed existing literature on methods to identify MRAs. The tool AT-HARM10 was developed using an iterative process including content validity and feasibility testing...
December 26, 2018: International Journal of Clinical Pharmacy
Macarena Merino Almazán, Juan Manuel Duarte Pérez, Juan Francisco Marín Pozo, Ana Laura Ortega Granados, Begoña Muros De Fuentes, Paz Quesada Sanz, Ana Isabel Gago Sánchez, Patricia Rodríguez Gómez, José Miguel Jurado García, Fátima Artime Rodríguez-Hermida, María José Martínez Bautista, Antonio Rueda Ramos, Beatriz Mora Rodríguez, María Carmen Martínez Díaz, Pablo Nieto Guindo, Margarita Garrido Siles, Rosa Villatoro Roldán, José Carlos Roldán Morales, Silvia María Artacho Criado, Úrsula Baños Roldán, Ángel Inoriza Rueda, María Teresa Garrido Martínez
Background Immunotherapy has become a standard treatment for lung cancer; however, the high cost makes it necessary to assess health outcomes. Objective The aim of this study was to evaluate the effectiveness, safety and economic cost of nivolumab in real-world clinical practice. Setting Fifteen regional and academic hospitals from Spain participated in this study. Methods This study was a retrospective, multicentre and observational study involving patients who experienced progression after first-line therapy for non-small-cell lung cancer and were treated with nivolumab between January 2016 and July 2017...
December 22, 2018: International Journal of Clinical Pharmacy
Steven R Erickson, Yanmen Yang
Background Medication management is undertaken by caregivers of people who have intellectual or developmental disabilities. Objective The objectives were to measure the medication management hassles reported by caregivers of adults who have intellectual or developmental disabilities and to describe associations between characteristics of caregivers, medication regimens, and the person with intellectual or developmental disability and the scale score. Setting Web-based survey conducted in the United States. Method A newsletter announcement with a link to the survey was sent to members of a disability advocacy organization...
December 22, 2018: International Journal of Clinical Pharmacy
Tin Fei Sim, Bruce Sunderland, H Laetitia Hattingh
Background Practising pharmacists continuously develop their ethical reasoning skills, which evolve with practice experience and exposure to challenging scenarios. Considering the recent expansion of the roles of pharmacists and the paradigm shift in pharmacy practice, it is timely to explore community pharmacists' attitudes regarding the importance of ethics and their ethical reasoning. Objective To explore underlying factors influencing community pharmacists' and pharmacy students' ethical reasoning and attitudes towards pharmacy ethics, ethical reasoning processes and perceived current dilemmas...
December 22, 2018: International Journal of Clinical Pharmacy
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