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Cardiorenal Medicine

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https://www.readbyqxmd.com/read/29118772/one-year-conservative-care-using-sodium-bicarbonate-supplementation-is-associated-with-a-decrease-in-electronegative-ldl-in-chronic-kidney-disease-patients-a-pilot-study
#1
Felipe Rizzetto, Denise Mafra, Ana Beatriz Barra, Gisella Pires de Melo, Dulcinéia Saes Parra Abdalla, Maurilo Leite
Background: Chronic kidney disease (CKD) patients develop metabolic acidosis when approaching stages 3 and 4, a period in which accelerated atherogenesis may ensue. Studies in vitro show that low pH may increase low-density lipoprotein (LDL) oxidation, suggesting a role for chronic metabolic acidosis in atherosclerosis. The present study attempted to evaluate the effects of conservative care using oral sodium bicarbonate (NaHCO3) supplementation on the electronegative LDL [LDL(-)], a minimally oxidized LDL, plasma levels in CKD patients...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29118771/a-profile-of-renal-function-in-northern-cameroonians-with-essential-hypertension
#2
Marcel Tangyi Tamanji, Divine Amagho Ngwakum, Olivier Pancha Mbouemboue
Background/Aim: The two-way cause and effect relationship existing between high blood pressure and kidney dysfunction is currently a well-documented phenomenon with patients in either category being almost equally predisposed to the other pathology. Our goal was to assess the renal function capacity of hypertensive patients in our setting. Methods: This cross-sectional descriptive study involved the determination of blood pressure levels and the collection of blood and urine samples for the measurement of renal function markers...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29118770/contrast-induced-nephropathy-is-less-common-in-patients-with-good-coronary-collateral-circulation
#3
Eyup Avci, Tarik Yildirim, Hasan Kadi
Background/Aims: Contrast-induced nephropathy (CIN) is a typically reversible type of acute renal failure that develops after exposure to contrast agents; underlying endothelial dysfunction is thought to be an important risk factor for CIN. Although the mechanism of coronary collateral circulation (CCC) is not fully understood, a pivotal role of the endothelium has been reported in many studies. The aim of this study was to investigate whether there is a relationship between CCC and CIN...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29118769/clinical-usefulness-of-urinary-liver-fatty-acid-binding-protein-excretion-for-predicting-acute-kidney-injury-during-the-first-7-days-and-the-short-term-prognosis-in-acute-heart-failure-patients-with-non-chronic-kidney-disease
#4
Akihiro Shirakabe, Noritake Hata, Nobuaki Kobayashi, Hirotake Okazaki, Masato Matsushita, Yusaku Shibata, Suguru Nishigoori, Saori Uchiyama, Kuniya Asai, Wataru Shimizu
Background: The clinical significance of urinary liver fatty acid-binding protein (u-LFABP) in acute heart failure (AHF) patients remains unclear. Methods and Results: The u-LFABP levels on admission of 293 AHF patients were analyzed. The patients were divided into 2 groups according to the u-LFABP quartiles (Q1, Q2, and Q3 = low u-LFABP [L] group vs. Q4 = high u-LFABP [H] group). We evaluated the diagnostic and prognostic value of u-LFABP and compared the findings between the chronic kidney disease (CKD; n = 165) and non-CKD patients (n = 128)...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29118768/the-relationship-between-hypertriglyceridemic-waist-phenotype-and-early-diabetic-nephropathy-in-type-2-diabetes
#5
Chun-Ming Ma, Rui Wang, Xiao-Li Liu, Na Lu, Qiang Lu, Fu-Zai Yin
Background/Aims: The aim of this study was to explore the relationship between hypertriglyceridemic waist (HW) phenotype and early diabetic nephropathy in type 2 diabetes. Methods: A cross-sectional study was conducted on 538 type 2 diabetes patients in Qinhuangdao. The HW phenotype was defined as serum triglyceride concentrations ≥1.7 mmol/L and waist circumference ≥90 cm (males) and ≥85 cm (females). Results: The prevalence of the HW phenotype was 34...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29118767/long-term-progression-of-coronary-artery-calcification-is-independent-of-classical-risk-factors-c-reactive-protein-and-parathyroid-hormone-in-renal-transplant-patients
#6
Sibel Gulcicek, Carmine Zoccali, Deniz Çebi Olgun, Giovanni Tripepi, Selma Alagoz, Serkan Feyyaz Yalın, Sinan Trabulus, Mehmet R Altiparmak, Nurhan Seyahi
Aims: Compared to the general population, mortality is significantly increased in renal transplant recipients. In the general population, coronary artery calcification (CAC) and its evolution over time are associated with cardiovascular and all-cause mortality, and the study of this biomarker could provide useful information for describing the long-term progression of coronary heart disease in renal transplant recipients. Methods: We followed up a cohort of 113 renal transplant patients by performing three multi-detector computed tomography studies over 83...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29118766/the-role-of-endotoxin-in-the-setting-of-cardiorenal-syndrome-type-5
#7
REVIEW
Anna Clementi, Grazia Maria Virzì, Alessandra Brocca, Claudio Ronco
Lipopolysaccharide or endotoxin, the major cell wall component of gram-negative bacteria, plays a pivotal role in the pathogenesis of sepsis. It is able to activate the host defense system through the interaction with Toll-like receptor 4, thus triggering pro-inflammatory mechanisms. When the production of inflammatory mediators becomes uncontrolled and excessive, septic shock develops with multiple organ dysfunction, such as myocardial and renal impairment, which are hallmarks of cardiorenal syndrome type 5...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29118765/urinary-liver-type-fatty-acid-binding-protein-level-as-a-predictive-biomarker-of-acute-kidney-injury-in-patients-with-acute-decompensated-heart-failure
#8
Keiichi Hishikari, Hiroyuki Hikita, Shun Nakamura, Shun Nakagama, Masahumi Mizusawa, Tasuku Yamamoto, Junichi Doi, Yosuke Hayashi, Yuya Utsugi, Makoto Araki, Yuta Sudo, Shigeki Kimura, Atsushi Takahashi, Takashi Ashikaga, Mitsuaki Isobe
Background: There are no biological markers to predict the onset of acute kidney injury (AKI) in patients with acute decompensated heart failure (ADHF). Liver-type fatty acid-binding protein (L-FABP) levels are markedly upregulated in the proximal tubules after renal ischemia. We investigated whether urinary L-FABP is a suitable marker to predict AKI in ADHF patients. Methods: We examined 281 consecutive patients with ADHF. Serum creatinine (Cr) and L-FABP levels were measured at admission and 24 and 48 h after admission...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29118764/folic-acid-and-homocysteine-in-chronic-kidney-disease-and-cardiovascular-disease-progression-which-comes-first
#9
REVIEW
Giuseppe Cianciolo, Antonio De Pascalis, Luca Di Lullo, Claudio Ronco, Chiara Zannini, Gaetano La Manna
Background: Hyperhomocysteinemia (Hhcy) occurs in about 85% of chronic kidney disease (CKD) patients because of impaired renal metabolism and reduced renal excretion. Folic acid (FA), the synthetic form of vitamin B9, is critical in the conversion of homocysteine (Hcy) to methionine. If there is not enough intake of FA, there is not enough conversion, and Hcy levels are raised. Summary: Hhcy is regarded as an independent predictor of cardiovascular morbidity and mortality in end-stage renal disease...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28736565/urinary-osteopontin-predicts-incident-chronic-kidney-disease-while-plasma-osteopontin-predicts-cardiovascular-death-in-elderly-men
#10
Tobias Feldreich, Axel C Carlsson, Johanna Helmersson-Karlqvist, Ulf Risérus, Anders Larsson, Lars Lind, Johan Ärnlöv
BACKGROUND AND OBJECTIVES: The matricellular protein osteopontin is involved in the pathogenesis of both kidney and cardiovascular disease. However, whether circulating and urinary osteopontin levels are associated with the risk of these diseases is less studied. DESIGN SETTING PARTICIPANTS AND MEASUREMENTS: A community-based cohort of elderly men (Uppsala Longitudinal Study of Adult Men [ULSAM]; n = 741; mean age: 77 years) was used to study the associations between plasma and urinary osteopontin, incident chronic kidney disease, and the risk of cardiovascular death during a median of 8 years of follow-up...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28736564/characterization-of-an-animal-model-to-study-risk-factors-and-new-therapies-for-the-cardiorenal-syndrome-a-major-health-issue-in-our-aging-population
#11
Anja Verhulst, Ellen Neven, Patrick C D'Haese
BACKGROUND: The cardiorenal syndrome (CRS) is a major health problem in our aging population. The term was introduced to cover disorders of the kidneys and heart, whereby dysfunction of one organ may induce dysfunction of the other. As the natural history of the CRS is mostly slow, hence difficult to explore in clinical trials, adequate animal models combining cardiovascular and renal disease are required. Therefore, we developed and characterized a usable model for CRS type 4, i.e. chronic kidney disease (CKD) causing cardiac dysfunction...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28736563/estimated-glomerular-filtration-rate-and-6-minute-walk-distance-in-african-americans-with-mild-to-moderate-heart-failure
#12
Karen M Vuckovic, Houry Puzantian
BACKGROUND/AIMS: The 6-minute walk test is a measure of functional capacity in patients with heart failure (HF) or chronic kidney disease (CKD). The association between estimated glomerular filtration rate (eGFR) and 6-minute walk distance (6MWD) has not been investigated in African-Americans (AA), despite them having a higher incidence of CKD and chronic HF. Thus, our aim was to determine if eGFR was an independent predictor of 6MWD in AA >50 years of age with HF. METHODS: In this cross-sectional study, we examined the relationship between eGFR and 6MWD in 45 AA patients with HF from an urban outpatient HF clinic, using logistic regression with bootstrapping...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28736562/brain-natriuretic-peptide-is-a-marker-of-fluid-overload-in-incident-hemodialysis-patients
#13
Charles Chazot, Margaux Rozes, Cyril Vo-Van, Patrik Deleaval, Jean-Marc Hurot, Christie Lorriaux, Brice Mayor, Eric Zaoui, Guillaume Jean
BACKGROUND/AIMS: Brain natriuretic peptide (BNP) is secreted by cardiomyocytes under stretch condition. High blood levels are associated with decreased patient survival in heart failure patients and in hemodialysis (HD) patients. We report the monthly BNP change in the first months of HD therapy in incident patients and its relationship with fluid removal and cardiac history (CH). METHODS: All patients starting HD therapy in our unit from May 2008 to December 2012 were retrospectively analyzed...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28736561/recent-advances-in-stroke-prevention-in-patients-with-atrial-fibrillation-and-end-stage-renal-disease
#14
REVIEW
Federico Ronco, Patrizio Mazzone, Leila Hosseinian, Simonetta Genovesi
BACKGROUND: Chronic kidney disease (CKD) is associated with a high prevalence of atrial fibrillation (AF), but in this population the risk/benefit ratio of anticoagulant therapy with vitamin K antagonists (VKA) for thromboprophylaxis is uncertain. SUMMARY: In end-stage renal disease (ESRD) patients undergoing hemodialysis, VKA seem less effective in stroke prevention than in the general population, with an increased risk of major bleeding. Recently, novel oral anticoagulant agents (NOACs) have proven to be effective for stroke prevention in AF and have demonstrated an improved safety profile compared to VKA...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28736560/nonparallel-progression-of-left-ventricular-structure-and-function-in-long-term-peritoneal-dialysis-patients
#15
Qiuhong Shi, Jing Zhu, Sheng Feng, Huaying Shen, Jianchang Chen, Kai Song
BACKGROUND/AIMS: Left ventricular hypertrophy and dysfunction are key cardiovascular risk factors of patients on peritoneal dialysis (PD). The purpose of this study was to investigate the dynamic changes of left ventricular (LV) structure and function in patients on long-term PD. METHODS: Patients who underwent PD catheter insertions from January 2010 to December 2012 in our PD center were enrolled into this study. Cardiac structure and function of those patients were determined by echocardiography (4 times) at 12-month intervals...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28736559/levocarnitine-injections-decrease-the-need-for-erythropoiesis-stimulating-agents-in-hemodialysis-patients-with-renal-anemia
#16
Takashi Maruyama, Terumi Higuchi, Toshio Yamazaki, Erina Okawa, Hideyuki Ando, Osamu Oikawa, Atsushi Inoshita, Kazuyoshi Okada, Masanori Abe
AIMS: The aim of this study was to evaluate the efficacy of levocarnitine injection for renal anemia in hemodialysis patients. METHODS: In this randomized controlled clinical trial, we randomly assigned patients on maintenance hemodialysis at our hospital to receive levocarnitine injections (n = 30) or no injection (n = 30) and monitored the patients during 12 months of treatment. In the treatment group, patients received an injection of levocarnitine 1,000 mg 3 times weekly after hemodialysis sessions...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28736558/evaluation-of-the-crusade-risk-score-for-predicting-major-bleeding-in-patients-with-concomitant-kidney-dysfunction-and-acute-coronary-syndromes
#17
Marianela Sánchez-Martínez, Pedro J Flores-Blanco, Ángel A López-Cuenca, María J Sánchez-Galián, Miriam Gómez-Molina, Francisco Cambronero-Sánchez, Esther Guerrero-Pérez, Mariano Valdés, James L Januzzi, Sergio Manzano-Fernández
BACKGROUND: Kidney dysfunction (KD) has been associated with increased risk for major bleeding (MB) in patients with acute coronary syndromes (ACS) and may be in part related to an underuse of evidence-based therapies. Our aim was to assess the predictive ability of the Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines (CRUSADE) risk score in patients with concomitant ACS and chronic kidney disease. METHODS: We conducted a retrospective analysis of a prospective registry including 1,587 ACS patients...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28736557/the-effect-of-admission-renal-function-on-the-treatment-and-outcome-of-patients-with-acute-coronary-syndrome
#18
Zach Rozenbaum, Sydney Benchetrit, Saar Minha, Yoram Neuman, Meital Shlezinger, Ilan Goldenberg, Morris Mosseri, David Pereg
BACKGROUND: Chronic kidney disease is a frequent comorbidity among patients with acute coronary syndrome (ACS). We aimed to evaluate treatment characteristics in ACS patients according to their renal function and to assess the effect of differences in therapy on clinical outcomes. METHODS: Included were patients with ACS enrolled in the biennial Acute Coronary Syndrome Israeli Surveys (ACSIS) during 2000-2013. Excluded were patients with cardiogenic shock at presentation...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28611789/association-of-growth-differentiation-factor-15-with-mortality-in-a-prospective-hemodialysis-cohort
#19
Amy S You, Kamyar Kalantar-Zadeh, Lorena Lerner, Tracy Nakata, Nancy Lopez, Lidia Lou, Mary Veliz, Melissa Soohoo, Jennie Jing, Frank Zaldivar, Jeno Gyuris, Danh V Nguyen, Connie M Rhee
BACKGROUND/AIMS: Cardiovascular disease and protein-energy wasting are among the strongest predictors of the high mortality of dialysis patients. In the general population, the novel cardiovascular and wasting biomarker, growth differentiation factor 15 (GDF15), is associated with decreased survival. However, little is known about GDF15 in dialysis patients. METHODS: Among prevalent hemodialysis patients participating in a prospective study (October 2011 to August 2015), we examined the association of baseline GDF15 levels with all-cause mortality using unadjusted and case mix-adjusted death hazard ratios (HRs) that controlled for age, sex, race, ethnicity, diabetes, and dialysis vintage...
February 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28611788/prognostic-implications-of-chronic-kidney-disease-on-patients-presenting-with-st-segment-elevation-myocardial-infarction-with-versus-without-stent-thrombosis
#20
Gilad Margolis, Shahar Vig, Nir Flint, Shafik Khoury, Michael Barkagan, Gad Keren, Yacov Shacham
BACKGROUND: Limited data is present regarding long-term outcomes in chronic kidney disease (CKD) patients presenting with stent thrombosis (ST). We evaluated the possible implications of CKD on long-term mortality in patients presenting with ST-segment elevation myocardial infarction (STEMI) and treated with primary percutaneous coronary intervention (PCI), and its interaction with the presence of ST. METHODS: We retrospectively studied 1,722 STEMI patients treated with primary PCI...
February 2017: Cardiorenal Medicine
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