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Cardiorenal Medicine

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https://www.readbyqxmd.com/read/29972826/plasma-level-of-retinol-binding-protein-4-n-terminal-probnp-and-renal-function-in-older-patients-hospitalized-for-heart-failure
#1
Marcin Majerczyk, Piotr Choręza, Katarzyna Mizia-Stec, Maria Bożentowicz-Wikarek, Aniceta Brzozowska, Habibullah Arabzada, Aleksander J Owczarek, Aleksandra Szybalska, Tomasz Grodzicki, Andrzej Więcek, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek
BACKGROUND/AIM: Elevated plasma concentration of retinol-binding protein 4 (RBP4) has recently emerged as a potential new risk factor for cardiovascular diseases, including hypertension (HT) and coronary artery disease (CAD). Limited data suggest that RBP4 promotes inflammatory damage to cardiomyocytes and participates in the development of heart failure (HF). This study aimed to analyze the relationship between concentrations of plasma RBP4 and serum N-terminal proBNP (NT-proBNP), a powerful biomarker of left ventricle dysfunction, in the older Polish population...
July 4, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29961069/differential-impact-of-chronic-kidney-disease-on-coronary-calcification-and-atherosclerosis-in-asymptomatic-individuals-with-or-without-diabetes-analysis-from-a-coronary-computed-tomographic-angiography-registry
#2
Ik Jun Choi, Sungmin Lim, Eun-Ho Choo, Jin-Jin Kim, Byung-Hee Hwang, Tae-Hoon Kim, Suk Min Seo, Yoon-Seok Koh, Dong Il Shin, Hun-Jun Park, Pum-Joon Kim, Doo-Soo Jeon, Seung-Hwan Lee, Jae-Hyoung Cho, Jung-Im Jung, Kiyuk Chang, Ki-Bae Seung
AIM: The aim of this study was to assess the combined effects of chronic kidney disease (CKD) and diabetes on the extent and developmental pattern of coronary artery disease (CAD). METHODS: A total of 3,017 self-referred asymptomatic individuals without known CAD who underwent 64-channel dual-source coronary computed tomography angiography between 2006 and 2010 were enrolled. The patients were divided into six groups based on their diabetes status (nondiabetic or diabetic) and estimated glomerular filtration rate (eGFR) (eGFR > 90 mL/min/1...
June 29, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29909417/metabolic-syndrome-and-the-iodine-dose-creatinine-clearance-ratio-as-determinants-of-contrast-induced-acute-kidney-injury
#3
Ali Amiri, Reza Ghanavati, Hassan Riahi Beni, Seyyed Hashem Sezavar, Mehrdad Sheykhvatan, Mahsa Arab
BACKGROUND: Finding patients at risk of developing contrast-induced acute kidney injury (CI-AKI) is important because of its associated complications. In the present study, the contribution of different variables, such as the presence of metabolic syndrome (MetS), the volume creatinine clearance (V/CrCl) ratio, the iodine-dose (I-dose)/CrCl ratio, or hypertension, to CI-AKI was evaluated. METHODS: A total of 255 patients undergoing elective coronary angiography with or without intervention were enrolled and divided into a MetS and a control group...
June 15, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29847820/determinants-of-monocyte-apoptosis-in-cardiorenal-syndrome-type-1
#4
Andrea Breglia, Grazia Maria Virzì, Silvia Pastori, Alessandra Brocca, Massimo de Cal, Chiara Bolin, Giorgio Vescovo, Claudio Ronco
BACKGROUND: Cardiorenal syndrome type 1 (CRS type 1) is characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). Its pathophysiology is complex and not completely understood. In this study, we examined the role of apoptosis and the caspase pathways involved. MATERIAL AND METHODS: We enrolled 40 acute heart failure (AHF) patients, 11 of whom developed AKI characterizing CRS type 1. We exposed the human cell line U937 to plasma from the CRS type 1 and AHF groups and then we evaluated apoptotic activity by annexin-V evaluation, determination of caspase-3, -8 and -9 levels, and BAX, BAD, and FAS gene expression...
May 30, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29723863/epicardial-fat-thickness-in-patients-with-autosomal-dominant-polycystic-kidney-disease
#5
Antonio Concistrè, Luigi Petramala, Gianmarco Scoccia, Susanna Sciomer, Valeria Bisogni, Vincenza Saracino, Gino Iannucci, Silvia Lai, Daniela Mastroluca, Gianluca Iacobellis, Claudio Letizia
INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is associated with early organ damage such as left ventricular hypertrophy and higher cardiovascular risk when compared to essential hypertension (EH). Epicardial adipose tissue (EAT) is a new cardiovascular risk factor, but its role and correlation with left ventricular mass (LVM) in ADPKD is unknown. AIMS: we sought to investigate whether EAT is higher and related to LVM indexed by body surface area (LVMi) in hypertensive patients with ADPKD compared to those with EH...
May 3, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29642067/%C3%AF-3-polyunsaturated-fatty-acid-postconditioning-protects-the-isolated-perfused-rat-heart-from-ischemia-reperfusion-injury
#6
Fu-Wei Zhang, Jian Tong, Yu-Sheng Yan, Qun-Qing Chen, Xiao-Ping Zhao
AIMS: This study aimed to evaluate the cardioprotective effects of ω-3 polyunsaturated fatty acids (PUFAs) postconditioning against ischemia-reperfusion (I/R) injury. METHODS: Sixty Sprague-Dawley rats were randomly divided into 4 groups (n = 15 for each) and used to generate the Langendorff isolated perfused rat heart model. The sham group received a continuous perfusion of 150 min. The remaining three I/R-treated groups sequentially received a 30-min perfusion, a 30-min cardioplegia, and a 90-min reperfusion...
April 11, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29635242/pulmonary-catherization-data-correlate-poorly-with-renal-function-in-heart-failure
#7
Luke Masha, James Stone, Danielle Stone, Jun Zhang, Luo Sheng
BACKGROUND: The mechanisms of renal dysfunction in heart failure are poorly understood. We chose to explore the relationship of cardiac filling pressures and cardiac index (CI) in relation to renal dysfunction in advanced heart failure. OBJECTIVES: To determine the relationship between renal function and cardiac filling pressures using the United Network of Organ Sharing (UNOS) pulmonary artery catherization registry. METHODS: Patients over the age of 18 years who were listed for single-organ heart transplantation were included...
April 10, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29627841/preeclampsia-as-a-form-of-type-5-cardiorenal-syndrome-an-underrecognized-entity-in-women-s-cardiovascular-health
#8
Janani Rangaswami, Mario Naranjo, Peter A McCullough
BACKGROUND: Preeclampsia is a multisystem vascular disorder of pregnancy that remains a leading cause of maternal and fetal morbidity and mortality. Preeclampsia remains an underrecognized risk factor for future cardiovascular and kidney disease in women and represents the confluence of preexisting vascular risk factors with superimposed endothelial injury from placental mediated anti-angiogenic factors. SUMMARY: This review highlights the close relationship between preeclampsia and future cardiovascular and kidney disease...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29617006/relevance-of-b-lines-on-lung-ultrasound-in-volume-overload-and-pulmonary-congestion-clinical-correlations-and-outcomes-in-patients-on-hemodialysis
#9
Marc M Saad, Jeanne Kamal, Elias Moussaly, Boutros Karam, Wissam Mansour, Emad Gobran, Saqib Hussen Abbasi, Ahmed Mahgoub, Puja Singh, Ross Hardy, Devjani Das, Cara Brown, Monica Kapoor, Seleshi Demissie, Morton J Kleiner, Elie El Charabaty, Suzanne E El Sayegh
BACKGROUND: Volume overload in patients on hemodialysis (HD) is an independent risk factor for cardiovascular mortality. B-lines detected on lung ultrasound (BLUS) assess extravascular lung water. This raises interest in its utility for assessing volume status and cardiovascular outcomes. METHODS: End-stage renal disease patients on HD at the Island Rehab Center being older than 18 years were screened. Patients achieving their dry weight (DW) had a lung ultrasound in a supine position...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29617005/high-right-ventricular-stroke-work-index-is-associated-with-worse-kidney-function-in-patients-with-heart-failure-with-preserved-ejection-fraction
#10
Napatt Kanjanahattakij, Natee Sirinvaravong, Francisco Aguilar, Akanksha Agrawal, Parasuram Krishnamoorthy, Shuchita Gupta
BACKGROUND: In patients with heart failure with preserved ejection fraction (HFpEF), worse kidney function is associated with worse overall cardiac mechanics. Right ventricular stroke work index (RVSWI) is a parameter of right ventricular function. The aim of our study was to determine the relationship between RVSWI and glomerular filtration rate (GFR) in patients with HFpEF. METHOD: This was a single-center cross-sectional study. HFpEF is defined as patients with documented heart failure with ejection fraction > 50% and pulmonary wedge pressure > 15 mm Hg from right heart catheterization...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29617004/impact-of-chronic-kidney-disease-on-cardiovascular-and-renal-events-in-patients-undergoing-percutaneous-coronary-intervention-with-everolimus-eluting-stent-risk-stratification-with-c-reactive-protein
#11
Kazuhiro Dan, Toru Miyoshi, Makoto Nakahama, Tomofumi Mizuno, Kenzo Kagawa, Yoichiro Naito, Satoshi Kawada, Hiroshi Ito
BACKGROUND: Chronic kidney disease (CKD) and inflammation play critical roles in atherosclerosis. There is limited evidence regarding the relationship between CKD and patients receiving second-generation drug-eluting stents for coronary artery disease. OBJECTIVE: This study aimed to investigate the effect of CKD on cardiovascular and renal events in patients undergoing percutaneous coronary intervention (PCI) with everolimus-eluting stents (EES). METHODS: We analyzed 504 consecutive patients with stable angina pectoris and significant coronary artery stenosis treated with EES...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29617003/the-effect-of-mitochondrial-complex-i-linked-respiration-by-isoflurane-is-independent-of-mitochondrial-nitric-oxide-production
#12
Fuqi Xu, Shigang Qiao, Hua Li, Yanjun Deng, Chen Wang, Jianzhong An
BACKGROUND: Anesthetic preconditioning (APC) of the myocardium is mediated in part by reversible alteration of mitochondrial function. Nitric oxide (NO) inhibits mitochondrial respiration and may mediate APC-induced cardioprotection. In this study, the effects of isoflurane on different states of mitochondrial respiration during the oxidation of complex I-linked substrates and the role of NO were investigated. METHODS: Mitochondria were isolated from Sprague-Dawley rat hearts...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29617002/the-role-of-dendritic-and-endothelial-cells-in-cardiorenal-syndrome
#13
Grazia Maria Virzì, Jun Zhang, Federico Nalesso, Claudio Ronco, Peter A McCullough
BACKGROUNDS: Dendritic cells (DCs) are antigen-presenting cells that play a central role in innate and adaptive immune responses; however, the cross talk between cardiac and renal DCs in cardiorenal syndrome (CRS) has not yet been fully elucidated. In this setting, endothelial cells (ECs) also contribute to immune responses. SUMMARY: DC and EC activation and dysfunction have a central role in the pathogenesis of CRS. Regarding immune responses in CRS, it is unknown whether ECs may serve as antigen-presenting cells or act synergistically with DCs to actively participate in innate and adaptive immune responses...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29617001/personalized-statin-therapy-and-coronary-atherosclerotic-plaque-burden-in-asymptomatic-low-intermediate-risk-individuals
#14
Ranganath Muniyappa, Radwa A Noureldin, Khaled Z Abd-Elmoniem, Riham H El Khouli, Jatin Raj Matta, Ahmed Hamimi, Siri Ranganath, Colleen Hadigan, Lynnette K Nieman, Ahmed M Gharib
BACKGROUND: Current guidelines for the primary prevention of atherosclerotic cardiovascular disease are based on the estimation of a predicted 10-year cardiovascular disease risk and the average relative risk reduction estimates from statin trials. In the clinical setting, however, decision-making is better informed by the expected benefit for the individual patient, which is typically lacking. Consequently, a personalized statin benefit approach based on absolute risk reduction over 10 years (ARR10 benefit threshold ≥2...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29617000/statins-and-new-onset-diabetes-in-cardiovascular-and-kidney-disease-cohorts-a-meta-analysis
#15
Haroon Kamran, Eric Kupferstein, Navneet Sharma, Jocelyne G Karam, Alyson K Myers, Irini Youssef, James R Sowers, Deborah R Gustafson, Moro O Salifu, Samy I McFarlane
BACKGROUND: Statins have long been prescribed for the primary and secondary prevention of cardiovascular disease (CVD) and kidney disease. Their benefits and efficacy are widely accepted in current clinical practice, but like any other therapeutic agents, they have adverse effects. One of the emerging concerns with statin therapy is the development of new-onset diabetes mellitus (NODM), a dreaded risk factor for CVD and kidney disease and widely viewed as CVD equivalent. Accumulating evidence indicates that NODM is a consequence of statin use...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29616999/lncrna-uca1-is-a-novel-regulator-in-cardiomyocyte-hypertrophy-through-targeting-the-mir-184-hoxa9-axis
#16
Gaoliang Zhou, Chao Li, Jun Feng, Jing Zhang, Yanyan Fang
Cardiac hypertrophy is closely associated with a series of cardiovascular diseases, including heart failure and sudden death in particular. An in-depth comprehension of the pathogenesis of cardiac hypertrophy will improve the diagnosis and therapy of cardiac hypertrophy. It has been acknowledged that long noncoding RNAs/microRNAs (lncRNAs/miRNAs) are crucial regulators in diverse biological processes, including various cardiovascular diseases, in multiple manners. Nevertheless, the biological roles of lncRNA UCA1 and miR-184 in cardiac hypertrophy are scarcely reported...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29344028/combination-therapy-with-renin-angiotensin-system-blockers-and-vitamin-d-receptor-activators-for-predialysis-patients-is-associated-with-the-incidence-of-cardiovascular-events-after-dialysis-initiation-a-multicenter-nonrandomized-prospective-cohort-study
#17
Daijo Inaguma, Eri Ito, Shigehisa Koide, Kazuo Takahashi, Hiroki Hayashi, Midori Hasegawa, Yukio Yuzawa
Background: Several human studies reported that the combined use of renin-angiotensin system blockers (RASBs) and vitamin D receptor activators (VDRAs) resulted in decreased urinary protein excretion. However, it is unknown whether this combination therapy influences the incidence of cardiovascular (CV) events in dialysis patients. Methods: The study was a multicenter nonrandomized prospective cohort analysis including 1,518 patients. Patients were classified into 4 groups based on medications prescribed before dialysis initiation: those who did not receive RASBs or oral VDRAs (N group), those receiving only RASBs, those receiving only VDRAs, and those receiving a combination of RASBs and VDRAs (RD group)...
December 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29344027/plasma-volume-and-renal-function-predict-six-month-survival-after-hospitalization-for-acute-decompensated-heart-failure
#18
Kenneth C Bilchick, Nathaniel Chishinga, Alex M Parker, David X Zhuo, Mitchell H Rosner, LaVone A Smith, Hunter Mwansa, Jacob N Blackwell, Peter A McCullough, Sula Mazimba
Background: Plasma volume (PV) is contracted in stable patients with heart failure (HF) due to decongestion strategies. On the other hand, increased PV can adversely affect the trajectory of HF. We therefore examined the effects of increased percentage change in PV (%ΔPV), blood urea nitrogen (BUN), and %ΔPV stratified by BUN and glomerular filtration rate (GFR) on survival after discharge in patients hospitalized for acute decompensated HF (ADHF). Methods: We used the Strauss-Davis-Rosenbaum formula to calculate the %ΔPV between baseline and hospital discharge in a cohort from the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness trial (ESCAPE)...
December 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29344026/evaluation-of-the-predictive-value-of-the-serum-calcium-magnesium-ratio-for-all-cause-and-cardiovascular-mortality-in-incident-dialysis-patients
#19
Hiroyuki Sato, Youichi Takeuchi, Ken Matsuda, Ayako Saito, Saeko Kagaya, Hirotaka Fukami, Yoshie Ojima, Tasuku Nagasawa
Background/Aim: Cardiovascular disease is the most serious cause of death in patients on hemodialysis. Low serum magnesium (Mg) and high serum calcium (Ca) levels have been associated with poor outcome and cardiovascular mortality in patients on maintenance and initiation dialysis. As a more accurate marker is warranted, we evaluated the efficacy of a novel serum Ca-Mg marker of all-cause and cardiovascular mortality that indicates vessel calcification. Methods: We recruited 378 consecutive patients with end-stage renal disease who started dialysis between January 2009 and December 2015 at the Japanese Red Cross Ishinomaki Hospital...
December 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29344025/insulin-resistance-in-kidney-disease-is-there-a-distinct-role-separate-from-that-of-diabetes-or-obesity
#20
REVIEW
Adam Whaley-Connell, James R Sowers
Insulin resistance is a central component of the metabolic dysregulation observed in obesity, which puts one at risk for the development of type 2 diabetes and complications related to diabetes such as chronic kidney disease. Insulin resistance and compensatory hyperinsulinemia place one at risk for other risk factors such as dyslipidemia, hypertension, and proteinuria, e.g., development of kidney disease. Our traditional view of insulin actions focuses on insulin-sensitive tissues such as skeletal muscle, liver, adipose tissue, and the pancreas...
December 2017: Cardiorenal Medicine
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