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Cardiorenal Medicine

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https://www.readbyqxmd.com/read/28000801/erratum
#1
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[This corrects the article DOI: 10.1159/000448009.].
November 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27994605/the-triad-of-sleep-apnea-hypertension-and-chronic-kidney-disease-a-spectrum-of-common-pathology
#2
REVIEW
Fahad Aziz, Kunal Chaudhary
Obstructive sleep apnea (OSA), hypertension, and chronic kidney disease (CKD) are different entities and are generally managed individually most of the time. However, CKD, OSA, and hypertension share many common risk factors and it is not uncommon to see this complex triad together. In fact, they share similar pathophysiology and have been interlinked with each other. The common pathophysiology includes chronic volume overload, hyperaldosteronism, increased sympathetic activity, endothelial dysfunction, and increased inflammatory markers...
November 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27994604/asymptomatic-ventricular-arrhythmia-and-clinical-outcomes-in-chronic-kidney-disease-a-pilot-study
#3
Fabiana Oliveira Bastos Bonato, Renato Watanabe, Marcelo Montebello Lemos, José Luiz Cassiolato, Myles Wolf, Maria Eugênia Fernandes Canziani
BACKGROUND/AIMS: Ventricular arrhythmia is associated with increased risk of cardiovascular events and death in the general population. Sudden death is a leading cause of death in end-stage renal disease. We aimed at evaluating the effects of ventricular arrhythmia on clinical outcomes in patients with earlier stages of chronic kidney disease (CKD). METHODS: In a prospective study of 109 nondialyzed CKD patients (estimated glomerular filtration rate 34.8 ± 16.1 ml/min/1...
November 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27994603/fibroblast-growth-factor-23-and-hypophosphatemia-a-case-of-hypophosphatemia-along-the-rickets-osteomalacia-spectrum
#4
REVIEW
George T Georges, O Nájera, Kurt Sowers, James R Sowers
Phosphorus is a key component of bone, and a deficiency results in poor mineralization along with other systemic symptoms of hypophosphatemia. Various causes of hypophosphatemia with renal wasting of phosphorus have been identified. These include the Fanconi syndrome, various genetic mutations of fibroblast growth factor 23 (FGF23) handling and the sodium/phosphate cotransporter, and those due to FGF23 secretion by mesenchymal tumors. Depending on the cause, vitamin D metabolism may also be impaired, which may amplify the deficiency in phosphorus and render treatment more challenging...
November 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27994602/vasodilation-and-exercise-capacity-in-patients-with-end-stage-renal-disease-a-prospective-proof-of-concept-study
#5
Dirk Habedank, Joerg C Schefold, Carolin Bernhardt, Tim Karhausen, Wolfram Doehner, Stefan D Anker, Petra Reinke
BACKGROUND: Previous data have pointed to the fact that vascular function is significantly impaired in patients with end-stage renal disease (ESRD). We aimed to better characterise vasodilation and exercise capacity in both ESRD and chronic heart failure (CHF) patients. METHODS: A total of 30 ESRD patients (23 male; mean age 45.7 ± 9.9 years) were included in a prospective proof-of-concept study at a tertiary care academic centre. The patients underwent forearm venous plethysmography with post-ischaemic peak blood flow (PF) and flow-dependent flow (FDF) testing as well as cardiopulmonary exercise testing during the morning of the day following the last haemodialysis...
November 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27994601/the-renal-arterial-resistance-index-predicts-worsening-renal-function-in-chronic-heart-failure-patients
#6
Massimo Iacoviello, Francesco Monitillo, Marta Leone, Gaetano Citarelli, Annalisa Doronzo, Valeria Antoncecchi, Agata Puzzovivo, Caterina Rizzo, Maria Silvia Lattarulo, Francesco Massari, Pasquale Caldarola, Marco Matteo Ciccone
BACKGROUND/AIM: The renal arterial resistance index (RRI) is a Doppler measure, which reflects abnormalities in the renal blood flow. The aim of this study was to verify the value of RRI as a predictor of worsening renal function (WRF) in a group of chronic heart failure (CHF) outpatients. METHODS: We enrolled 266 patients in stable clinical conditions and on conventional therapy. Peak systolic velocity and end diastolic velocity of a segmental renal artery were obtained by pulsed Doppler flow, and RRI was calculated...
November 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27994600/oxidized-low-density-lipoprotein-predicts-the-development-of-renal-dysfunction-in-atrial-fibrillation
#7
Marija Polovina, Ivana Petrović, Voin Brković, Milika Ašanin, Jelena Marinković, Miodrag Ostojić
BACKGROUND/AIM: To investigate the role of oxidative stress (OS) in the development of chronic kidney disease (CKD) in atrial fibrillation (AF). METHODS: We compared OS burden, determined at study inclusion as plasma concentrations of oxidized low-density lipoprotein (oxLDL), between stable AF patients (n = 256, mean age: 62.8 ± 9.3 years; 60.9% males) with preserved renal function, defined as an estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m(2), and a matched control group in sinus rhythm (n = 138, mean age: 61...
November 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27994599/possible-inhibitory-effect-of-erythropoiesis-stimulating-agents-at-the-predialysis-stage-on-early-phase-coronary-events-after-hemodialysis-initiation
#8
Masato Nishimura, Keitaro Watanabe, Yuki Kitamura, Takao Nagashima, Toshiko Tokoro, Toru Takatani, Nodoka Sato, Satoru Yamazaki, Tetsuya Hashimoto, Hiroyuki Kobayashi, Toshihiko Ono
BACKGROUND: We examined whether the use of erythropoiesis-stimulating agents (ESAs) to correct anemia at the predialysis stage could inhibit early-phase coronary events after hemodialysis initiation. METHODS: We enrolled 242 patients with chronic kidney disease who had received continued medical treatments and initiated maintenance hemodialysis from 1 September 2000 to 31 December 2014 at Toujinkai Hospital. Patients with a previous history of blood transfusion or any cardiovascular events or interventions were excluded...
November 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27994598/matrix-metalloproteinase-neutrophil-gelatinase-associated-lipocalin-complex-predicts-atrial-fibrillation-recurrence-after-electrical-cardioversion-in-obese-patients
#9
Elzbieta Mlodawska, Anna Tomaszuk-Kazberuk, Paulina Lopatowska, Ewa Waszkiewicz, Hanna Bachorzewska-Gajewska, Jolanta Malyszko, Ewelina Michniewicz, Slawomir Dobrzycki, Wlodzimierz Jerzy Musial
BACKGROUND: There is not much data on matrix metalloproteinase neutrophil gelatinase-associated lipocalin (MMP-NGAL) complex in patients with atrial fibrillation (AF). AIM: The aim of the study was to assess the value of MMP-NGAL complex in predicting AF recurrence after electrical cardioversion. METHODS: The serum levels of NGAL, cystatin C, interleukin-6, high-sensitivity C-reactive protein, copeptin, MMP-NGAL complex, matrix metalloproteinase 2, tissue inhibitor of metalloproteinase 1, Von Willebrand factor, B-type natriuretic peptide and the urinary level of NGAL were evaluated before cardioversion...
November 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27994597/aging-male-spontaneously-hypertensive-rat-as-an-animal-model-for-the-evaluation-of-the-interplay-between-contrast-induced-acute-kidney-injury-and-cardiorenal-syndrome-in-humans
#10
REVIEW
Jun Zhang, Mohammad Kazem Fallahzadeh, Peter A McCullough
BACKGROUND: Although there are some animal models for biomarkers of contrast-induced acute kidney injury (CI-AKI), for cardiorenal syndrome (CRS) and for acute renal failure, the interplay between CI-AKI and CRS has yet to be evaluated. Insight into the pathogenesis of CRS is urgently needed from animal models in order to foster the discovery and implementation of novel biomarkers for this disease. Specially designed animal models for type 1 and 3 CRS, particularly CI-AKI, have not yet emerged...
November 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27648015/brain-natriuretic-peptide-and-body-fluid-composition-in-patients-with-chronic-kidney-disease-a-cross-sectional-study-to-evaluate-the-relationship-between-volume-overload-and-malnutrition
#11
Yasushi Ohashi, Akinobu Saito, Keisuke Yamazaki, Reibin Tai, Tatsuru Matsukiyo, Atsushi Aikawa, Ken Sakai
BACKGROUND/AIM: Fluid volume overload occurs in chronic kidney disease (CKD), leading to the compensatory release of natriuretic peptides. However, the elevated cardiac peptides may also be associated with malnutrition as well as volume overload. METHODS: Body fluid composition was measured in 147 patients with CKD between 2009 and 2015, and its relationship to brain natriuretic peptide (BNP) levels was examined. Body fluid composition was separated into three components: (a) a water-free mass consisting of muscle, fat, and minerals; (b) intracellular water (ICW) content, and (c) extracellular water (ECW) content...
August 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27648014/evaluation-of-nephroprotective-efficacy-of-hypoxic-preconditioning-in-patients-undergoing-coronary-artery-bypass-surgery
#12
Zhaneta V Vesnina, Yury B Lishmanov, Ekaterina A Alexandrova, Evgeniy A Nesterov
BACKGROUND: Nonpulsatile blood flow plays an important role in the pathogenesis of renal dysfunction in patients with extracorporeal circulation. In our opinion, hypoxic preconditioning (HP) can be used to protect kidneys from postsurgical dysfunction. The aim of this study was to evaluate nephroprotective efficacy of HP in myocardial revascularization with extracorporeal circulation. METHODS: The randomized, controlled trial was performed in 63 patients undergoing coronary artery bypass grafting (CABG)...
August 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27648013/high-nacl-diet-aggravates-cardiac-injury-in-rats-with-adenine-induced-chronic-renal-failure-and-increases-serum-troponin-t-levels
#13
Pavlos Kashioulis, Ola Hammarsten, Niels Marcussen, Emman Shubbar, Aso Saeed, Gregor Guron
AIMS: To examine the effects of 2 weeks of high-NaCl diet on left ventricular (LV) morphology and serum levels of cardiac troponin T (cTnT) in rats with adenine-induced chronic renal failure (ACRF). METHODS: Male Sprague-Dawley rats either received chow containing adenine or were pair-fed an identical diet without adenine [controls (C)]. Approximately 10 weeks after the beginning of the study, the rats were randomized to either remain on a normal NaCl diet (NNa; 0...
August 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27648012/association-between-age-at-menarche-and-cardiovascular-disease-risk-factors-in-china-a-large-population-based-investigation
#14
Yansong Zheng, Guilan Zhang, Zhilai Chen, Qiang Zeng
BACKGROUND: The association between age at menarche (AAM) and cardiovascular disease (CVD) has previously been investigated with controversial results. The relationship between the psychological characteristic of AAM and many cardiovascular risk factors remains unclear. PURPOSE: To assess the association between AAM and CVD risk factors in a large population. DESIGN AND SETTING: 13,242 women aged 24-79 years were recruited from China mainland during 2009-2013 for a cross-sectional, population-based study to investigate the association between AAM and CVD risk factors...
August 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27648011/genetic-variants-in-toll-like-receptor-4-gene-and-their-association-analysis-with-estimated-glomerular-filtration-rate-in-mexican-american-families
#15
Farook Thameem, Sobha Puppala, Vidya S Farook, Balakuntalam S Kasinath, John Blangero, Ravindranath Duggirala, Hanna E Abboud
BACKGROUND/AIM: Toll-like receptor 4 (TLR4) is one of the regulators of the innate immune response. Genetic variations in TLR4 have been associated with inflammatory diseases, including type 2 diabetes. However, to our knowledge, there are no reports on the role of variations in TLR4 in chronic kidney disease susceptibility. The objective of this study is to determine whether the genetic variants in TLR4 are associated with the estimated glomerular filtration rate (eGFR), a measure of renal function...
August 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27648010/association-of-inflammation-prior-to-kidney-transplantation-with-post-transplant-diabetes-mellitus
#16
Maria P Martinez Cantarin, Scott W Keith, Zhao Lin, Cataldo Doria, Adam M Frank, Warren R Maley, Carlo Ramirez, Costas D Lallas, Ashesh Shah, Scott A Waldman, Bonita Falkner
BACKGROUND/OBJECTIVE: Post-transplant diabetes mellitus (PTDM) is both common and associated with poor outcomes after kidney transplantation. Our objective was to examine relationships of uremia-associated inflammation and adiponectin with PTDM. METHODS: Nondiabetic kidney transplant patients were enrolled with donor controls. Inflammatory cytokines and adiponectin were measured before and after transplantation. Adipose tissue was obtained for gene expression analysis...
August 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27648009/predictive-value-of-the-mehran-score-for-contrast-induced-nephropathy-after-transcatheter-aortic-valve-implantation-in-patients-with-aortic-stenosis
#17
Mustafa Zungur, Ilker Gul, Ahmet Tastan, Ertan Damar, Talat Tavli
BACKGROUND/AIMS: The Mehran risk score (MS) was adopted to predict the development of contrast-induced nephropathy (CIN) and includes clinical and procedural variables. In this study, we aimed to evaluate the value of MS in the prediction of CIN development after transcatheter aortic valve implantation (TAVI). METHODS: Ninety-three patients (47 females; mean age, 77.2 ± 7.6 years) who underwent aortic valve replacement with TAVI for severe aortic stenosis in our center between June 2013 and November 2014 were included in the study...
August 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27648008/impact-of-cardiorenal-anemia-syndrome-on-short-and-long-term-clinical-outcomes-in-patients-hospitalized-with-heart-failure
#18
Chan Joon Kim, Ik-Jun Choi, Hun-Jun Park, Tae Hoon Kim, Pum-Joon Kim, Kiyuk Chang, Sang Hong Baek, Wook Sung Chung, Ki-Bae Seung
BACKGROUND: Dysfunctional interplay between the heart and kidneys may lead to the development of anemia. The aim of this study was to evaluate the impact of cardiorenal anemia syndrome (CRAS) on short- and long-term outcomes among patients hospitalized with heart failure (HF). METHODS: We enrolled 303 patients hospitalized with HF. We divided the patients into two groups: a CRAS group (n = 64) and a non-CRAS group (n = 239). We defined CRAS as HF accompanied by (1) an estimated glomerular filtration rate <60 ml/min/1...
August 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27648007/beta-blocker-use-is-associated-with-higher-renal-tissue-oxygenation-in-hypertensive-patients-suspected-of-renal-artery-stenosis
#19
Michael E Hall, Michael V Rocco, Timothy M Morgan, Craig A Hamilton, Jennifer H Jordan, Matthew S Edwards, John E Hall, William G Hundley
BACKGROUND: Chronic renal hypoxia influences the progression of chronic kidney disease (CKD). Blood oxygen level-dependent (BOLD) magnetic resonance (MR) is a noninvasive tool for the assessment of renal oxygenation. The impact of beta-blockers on renal hemodynamics and oxygenation is not completely understood. We sought to determine the association between beta-blocker use, renal cortical and medullary oxygenation, and renal blood flow in patients suspected of renal artery stenosis. METHODS: We measured renal cortical and medullary oxygenation using BOLD MR and renal artery blood flow using MR phase contrast techniques in 38 participants suspected of renal artery stenosis...
August 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27275161/angiogenic-factors-and-risks-of-technique-failure-and-cardiovascular-events-in-patients-receiving-peritoneal-dialysis
#20
Masaru Matsui, Ken-Ichi Samejima, Yukiji Takeda, Katsuhiko Morimoto, Miho Tagawa, Kenji Onoue, Satoshi Okayama, Hiroyuki Kawata, Rika Kawakami, Yasuhiro Akai, Hiroyuki Okura, Yoshihiko Saito
BACKGROUND: Placental growth factor (PlGF) is a member of the vascular endothelial growth factor family that acts as a pleiotropic cytokine capable of stimulating angiogenesis and accelerating atherogenesis. Soluble fms-like tyrosine kinase-1 (sFlt-1) antagonizes PlGF action. Higher levels of PlGF and sFlt-1 have been associated with cardiovascular events in patients with chronic kidney disease, yet little is known about their relationship with adverse outcomes in patients on peritoneal dialysis (PD)...
May 2016: Cardiorenal Medicine
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