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International Journal of Ophthalmology

Xue-Ying Shi, Yi-Feng Ke, Nan Jin, Hong-Mei Zhang, Rui-Hua Wei, Xiao-Rong Li
AIM: To determine the prevalence of vision impairment (VI) and refractive error in first year university students at the Tianjin Medical University. METHODS: This is a cross-sectional observational cohort study of VI and refractive error among first year university students at the Tianjin Medical University. The first year university students were involved in this study and were given a detailed questionnaire including age, birth date, and spectacle wearing history...
2018: International Journal of Ophthalmology
Lu-Lu Chen, Qiong Wang, Wei-Hong Yu, You-Xin Chen
AIM: To determine acute and chronic choroidal vascular changes after vortex vein occlusion in monkeys. METHODS: One or two temporal vortex veins were occluded in 8 cynomolgus monkeys. Fluorescein angiography (FA), indocyanine green angiogram (ICGA), and enhanced-depth imaging optical coherence tomography (EDI-OCT) were performed preoperatively and at 1d, 1, 4, 8 and 12wk after occlusion. EDI-OCT images were binarized to calculate the choroid vascular index (CVI)...
2018: International Journal of Ophthalmology
Xiu-Lan Zou, Guan-Feng Wang, Dan-Dan Li, Jing-Xia Chen, Chun-Li Zhang, Yong-Zhen Yu, Wen-Jie Zhou, Yu-Ping Zou, Ben-Qiang Rao
AIM: To investigate the effect of tissue factor targeting peptide (TF-TP) on retinal pigment epithelium (RPE) cells tight junctions. METHODS: Cell counting kit-8 (CCK-8) was used to measure the proliferation of ARPE-19 cells. Expression of tight junction, ZO-1 in ARPE-19 cells was measured by Western blot and immunofluorescent staining. Western blot was also used to detect the expression of tissue factor (TF). CEC Transmigration Assay was used to measure the migration of ARPE-19 cells...
2018: International Journal of Ophthalmology
Jin Yang, Lin-Ni Wang, Rong-Guo Yu, Li-Ying Hu, Xue Gong, Lu Chen, Bo-Jie Hu, Xiao-Rong Li, Zhi-Qing Li
No abstract text is available yet for this article.
2018: International Journal of Ophthalmology
Yo Sep Yoon, Je Moon Woo, Jong Eun Woo, Jung Kee Min
To investigate the foveal morphological changes and foveal avascular zone (FAZ) area before and after epiretinal membrane (ERM) surgery. Twenty-two eyes with treatment-naive ERM were included in this retrospective study. The central foveal thickness (CFT) and FAZ area were measured via swept-source optical coherence tomography (SS-OCT) and OCT angiography pre- and postoperatively. The unaffected fellow eyes were used as controls. The preoperative superficial FAZ area was significantly smaller in patients (0...
2018: International Journal of Ophthalmology
Miki Uchino, Motoko Kawashima, Yuichi Uchino, Kazuo Tsubota, Norihiko Yokoi
AIM: To investigate the association between tear film break up time (TBUT) and blinking interval in visual display terminal (VDT) users. METHODS: Nine hundred and thirty VDT users underwent dry eye testing, and functional visual acuity (FVA) test. The blinking interval during FVA was compared with TBUT. Subjects with longer blinking interval than TBUT were considered as unstable tear film. Logistic regression analysis revealed the risk factors for unstable tear group...
2018: International Journal of Ophthalmology
Ji-Sun Moon, Sun Young Shin
AIM: To evaluate the efficacy and safety of three different concentrations of diluted atropine for the control of myopia in Korean children, and to assess the risk factors associated with rapid myopia progression. METHODS: A total of 285 children, with refractive errors within the range of -6 diopters (D) between 5 and 14 years of age were included. After using 0.01%, or 0.025%, or 0.05% atropine, for about 1y, changes in refraction, axial lengths and frequency of adverse events were analyzed...
2018: International Journal of Ophthalmology
Natalia Lobanovskaya, Monika Jürgenson, Anu Aonurm-Helm, Alexander Zharkovsky
AIM: To investigate the impact of polysialylated neural cell adhesion molecule (PSA-NCAM) on the survival of retinal ganglion cells (RGCs) in the experimentally induced diabetes in mice. METHODS: Diabetes was induced in 2.5 months old Swiss Webster mice by intraperitoneal injection of streptozotocin (STZ, 90 mg/kg) once daily for two consecutive days. Examination of the proteins of interest in the retinas from diabetic mice at 2mo after diabetes induction was performed using immunohistochemistry and Western blot analysis...
2018: International Journal of Ophthalmology
Mustafa Doğan, Anar Alizada, Güliz Fatma Yavaş, Orhan Kemal Kahveci, Osman Bakan
AIM: To evaluate the long-term sucess rate of laser-assisted dacryocystorhinostomy (L-DCR) in patients with nasolacrimal duct obstruction (NDO). METHODS: Forty-one eyes of forty patients aged between 21-85y (mean 56.7y) who underwent L-DCR for the treatment of NDO were included in this retrospective, non-randomized study. The follow-up time was 72mo. Functional sucess was defined as the disappearance of epiphora under normal conditions and the presence of a patent ostium on lacrimal irrigation...
2018: International Journal of Ophthalmology
Yong Zheng Wai, Lee Min Fiona Chew, Aziz Salowi Mohamad, Chai Liang Ang, Yong Yuin Chong, Tassha Hilda Adnan, Pik-Pin Goh
AIM: To report the incidence, risk factors and visual outcomes for postoperative endophthalmitis (POE) based on 7-year data from the Malaysian Ministry of Health Cataract Surgery Registry (MOH CSR). METHODS: Data was collected from the web-based MOH CSR. All consecutive cataract surgery patients from 1st June 2008 to 31st December 2014 were identified. Exclusion criteria were traumatic cataract or previous ocular surgery. Demographic data, ocular co-morbidities, intraoperative details and postoperative visual acuity (VA) at final ophthalmological follow-up were noted...
2018: International Journal of Ophthalmology
Wisam Shihadeh, Omar Khabour, Mohammed Bilal Khalil, Alaa Al-Dabbagh, Mustafa Al-Hashimi
AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the LOXL1 gene with exfoliation syndrome/glaucoma (XFS/XFG) among Jordanians. METHODS: Sixty-one patients with XFS/XFG and 59 healthy control individuals were recruited in the study. Patients were diagnosed with XFS/XFG using standard clinical examination techniques. The exonic rs1048661 SNP and the intronic rs2165241 SNP in LOXL1 gene were genotyped using sequencing technique...
2018: International Journal of Ophthalmology
Nattapong Mekhasingharak, Poramaet Laowanapiban, Sasitorn Siritho, Chanjira Satukijchai, Naraporn Prayoonwiwat, Jiraporn Jitprapaikulsan, Niphon Chirapapaisan
AIM: To compare the thickness of the peripapillary retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) among patients with various forms of optic neuritis (ON) and to identify whether any particular parameters or their thinning pattern can be used to distinguish the type of ON. METHODS: This prospective study was conducted at the Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Thailand, between January, 2015 and December, 2016...
2018: International Journal of Ophthalmology
Kenan Dagdelen, Emrah Dirican
AIM: To assess morphological changes in macula, retinal nerve fiber layer (RNFL) and optic nevre head (ONH) of cases with primary open angle glaucoma (POAG) and ocular hypertension (OH) with spectral domain optic coherence tomography (OCT). METHODS: This study included 109 eyes from 62 POAG patients, 50 eyes from 30 OH patients, and 101 eyes from 53 healthy volunteers. Data gained by OCT were compared with perimetry indexes. ONH, RNFL and macula analysis were performed for all subjects...
2018: International Journal of Ophthalmology
Jing-Jing Fan, Yong Tao, De-Kuang Hwang
AIM: To compare the effectiveness between multiple intravitreal injections of ganciclovir alone and combined with foscarnet as initial treatment for patients with newly-onset cytomegalovirus retinitis (CMVR). METHODS: The retrospective study observed 37 patients (58 eyes) who suffered from CMVR onset between 2013 and 2015. Among them, 35 eyes underwent 4 weekly intravitreal injections of 3.0 mg ganciclovir, and 23 eyes underwent 4 weekly injections of 3.0 mg ganciclovir combined with 2...
2018: International Journal of Ophthalmology
Serkan Akkaya
AIM: To determine lamina cribrosa thickness (LCT) in the optic nerve head region of the eyes in children with hyperopic anisometropic amblyopia and to compare this thickness with that of fellow eyes, hyperopic non-amblyopia, and age-matched controls. METHODS: Thirty-two patients (12.0±1.8y, mean± standard deviation) with hyperopic anisometropic amblyopia, 31 subjects with age- and refractive error-matched hyperopic non-amblyopia (10.7±2.2y), and 32 age-matched controls (11...
2018: International Journal of Ophthalmology
Peng Chen, Hao Chen, Xiao-Jing Pan, Su-Zhen Tang, Yu-Jun Xia, Hui Zhang
AIM: To summarize the phenotypes and identify the underlying genetic cause of the CRYBB1 and CRYBB2 gene responsible for congenital cataract in two Chinese families. METHODS: Detailed family histories and clinical data were collected from patients during an ophthalmologic examination. Of 523 inheritable genetic vision system-related genes were captured and sequenced by targeted next-generation sequencing, and the results were confirmed by Sanger sequencing. The possible functional impacts of an amino acid substitution were performed with PolyPhen-2 and SIFT predictions...
2018: International Journal of Ophthalmology
Min Liu, Shuo-Min Wang, Zheng-Xuan Jiang, Hennein Lauren, Li-Ming Tao
AIM: To explore the effect of miR-22 on viability, migration, invasion and apoptosis in retinoblastoma (RB) Y79 cells and to further detect the potential mechanism. METHODS: Plasmids were constructed to change the expression level of miR-22 in Y79 cells. Real-time reverse transcription polymerase chain reaction (RT-PCR) was conducted to test the expression level of miR-22. After changing the expression of miR-22, the mRNA and protein levels of high-mobility group box 1 (HMGB1) were investigated using RT-PCR and Western blotting...
2018: International Journal of Ophthalmology
Ivan Sencanic, Tatjana Gazibara, Jelena Dotlic, Miroslav Stamenkovic, Vesna Jaksic, Marija Bozic, Anita Grgurevic
AIM: To translate the Glaucoma Quality of Life-15 (GQL-15) to Serbian language and asses its validity and reliability in the population of Serbian patients. METHODS: The study included 177 glaucoma patients. Clinical parameters (visual acuity, mean defect and square root of loss variance of visual field) and socio-demographic data were collected. Patients were stratified according to the Nelson's glaucoma staging system as mild, moderate and advanced glaucoma. All patients filled out the GQL-15 and National Eye Institute Visual Function Questionnaire (NEI-VFQ 25)...
2018: International Journal of Ophthalmology
Da Teng, Chun-Xia Peng, Hai-Yan Qian, Li Li, Wei Wang, Jun-Qing Wang, Bing Chen, Huan-Fen Zhou, Shi-Hui Wei
AIM: To evaluate the structural injure patterns in peripapillary retinal fiber layer (pRNFL), retinal ganglion cell layer (RGCL) and their correlations to visual function in various mitochondrial optic neuropathies (MON) to offer help to their differential diagnosis. METHODS: Totally 32 MON patients (60 eyes) were recruited within 6mo after clinical onsets, including 20 Leber hereditary optic neuropathy (LHON) patients (37 eyes), 12 ethambutol-induced optic neuropathy (EON) patients (23 eyes), and 41 age-gender matched healthy controls (HC, 82 eyes)...
2018: International Journal of Ophthalmology
Mohamed Omar Yousif, Azza Mohamed Ahmed Said
AIM: To evaluate the efficacy of femtosecond laser assisted MyoRing intrastromal corneal implant and deep anterior lamellar keratoplasty (DALK) for management of moderate to advanced keratoconus regarding the degree of changes in visual acuity, refraction, corneal asphericity and aberrations. METHODS: A prospective non comparative interventional case study was conducted in Ophthalmology Department, Ain Shams University Hospital in the period from January 2015 to February 2017...
2018: International Journal of Ophthalmology
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