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Journal of Drug Delivery

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https://www.readbyqxmd.com/read/28127472/formulation-of-bilayer-benzydamine-hcl-patch-targeted-for-gingivitis
#1
Piyush Sanghai, Tanaji Nandgude, Sushilkumar Poddar
In the present study bilayer patch of benzydamine HCl was developed using solvent casting method. Different substrates were attempted like Petri dish, glass-and-ring, and teflon-and-ring for selection of the proper option to formulate patch that should give easily peelable film with adequate mechanical properties. HPMC E15 LV was used in different concentrations for obtaining proper viscosity of solution for pouring on to surface and ring, that it should not leak from ring. The second layer was optimized by using different polymer like eudragit RSPO, eudragit RSPO + EC, and eudragit NE30 D for efficient layer bonding...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/28044108/stabilized-polymer-micelles-for-the-development-of-it-147-an-epothilone-d-drug-loaded-formulation
#2
Adam Carie, Bradford Sullivan, Tyler Ellis, J Edward Semple, Taylor Buley, Tara Lee Costich, Richard Crouse, Suzanne Bakewell, Kevin Sill
Epothilones have demonstrated promising potential for oncology applications but suffer from a narrow therapeutic window. Epothilone D stabilizes microtubules leading to apoptosis, is active against multidrug-resistant cells, and is efficacious in animal tumor models despite lack of stability in rodent plasma. Clinical development was terminated in phase II due to dose limiting toxicities near the efficacious dose. Taken together, this made epothilone D attractive for encapsulation in a stabilized polymer micelle for improved safety and efficacy...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/27990303/thermochemical-properties-of-hydrophilic-polymers-from-cashew-and-khaya-exudates-and-their-implications-on-drug-delivery
#3
Emmanuel O Olorunsola, Partap G Bhatia, Babajide A Tytler, Michael U Adikwu
Characterization of a polymer is essential for determining its suitability for a particular purpose. Thermochemical properties of cashew gum (CSG) extracted from exudates of Anacardium occidentale L. and khaya gum (KYG) extracted from exudates of Khaya senegalensis were determined and compared with those of acacia gum BP (ACG). The polymers were subjected to different thermal and chemical analyses. Exudates of CSG contained higher amount of hydrophilic polymer. The pH of 2% w/v gum dispersions was in the order KYG < CSG < ACG...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/27965897/targeted-delivery-of-glucan-particle-encapsulated-gallium-nanoparticles-inhibits-hiv-growth-in-human-macrophages
#4
Ernesto R Soto, Olivia O'Connell, Fusun Dikengil, Paul J Peters, Paul R Clapham, Gary R Ostroff
Glucan particles (GPs) are hollow, porous 3-5 μm microspheres derived from the cell walls of Baker's yeast (Saccharomyces cerevisiae). The 1,3-β-glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing β-glucan receptors. GPs have been used for macrophage-targeted delivery of a wide range of payloads (DNA, siRNA, protein, small molecules, and nanoparticles) encapsulated inside the hollow GPs or bound to the surface of chemically derivatized GPs. Gallium nanoparticles have been proposed as an inhibitory agent against HIV infection...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/27867663/dry-powder-inhalers-a-focus-on-advancements-in-novel-drug-delivery-systems
#5
REVIEW
Piyush Mehta
Administration of drug molecules by inhalation route for treatment of respiratory diseases has the ability to deliver drugs, hormones, nucleic acids, steroids, proteins, and peptides, particularly to the site of action, improving the efficacy of the treatment and consequently lessening adverse effects of the treatment. Numerous inhalation delivery systems have been developed and studied to treat respiratory diseases such as asthma, COPD, and other pulmonary infections. The progress of disciplines such as biomaterials science, nanotechnology, particle engineering, molecular biology, and cell biology permits further improvement of the treatment capability...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/27803815/solid-lipid-nanoparticles-improve-the-diclofenac-availability-in-vitreous-after-intraocular-injection
#6
Mojtaba Abrishami, Majid Abrishami, Asma Mahmoudi, Navid Mosallaei, Mohammad Vakili Ahrari Roodi, Bizhan Malaekeh-Nikouei
Purpose. In order to improve the drug availability after intravitreal administration, solid lipid nanoparticles (SLNs) containing diclofenac were prepared. Methods. In this experimental study, 18 albino rabbits were included. In right and left eyes of all rabbits, SLNs containing diclofenac and commercial form of diclofenac (0.3 mg drug) were intravitreally injected, respectively. One, four, twelve, twenty-four, and forty-eight hours after injection, vitreous and aqueous humor samples were obtained in all cases...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/27800184/sustained-release-of-protein-therapeutics-from-subcutaneous-thermosensitive-biocompatible-and-biodegradable-pentablock-copolymers-ptsgels
#7
Elizabeth Schaefer, Santhi Abbaraju, Mary Walsh, Donna Newman, Jacklyn Salmon, Rasidul Amin, Sidney Weiss, Ulrich Grau, Poonam Velagaleti, Brian Gilger
Objective. To evaluate thermosensitive, biodegradable pentablock copolymers (PTSgel) for sustained release and integrity of a therapeutic protein when injected subcutaneously. Materials and Methods. Five PTSgels with PEG-PCL-PLA-PCL-PEG block arrangements were synthesized. In vitro release of IgG from PTSgels and concentrations was evaluated at 37°C. Released IgG integrity was characterized by SDS-PAGE. In vitro disintegration for 10GH PTSgel in PBS was monitored at 37°C over 72 days using gravimetric loss and GPC analysis...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/27610247/design-characterization-and-optimization-of-controlled-drug-delivery-system-containing-antibiotic-drug-s
#8
Apurv Patel, Hitesh Dodiya, Pragna Shelate, Divyesh Shastri, Divyang Dave
The objective of this work was design, characterization, and optimization of controlled drug delivery system containing antibiotic drug/s. Osmotic drug delivery system was chosen as controlled drug delivery system. The porous osmotic pump tablets were designed using Plackett-Burman and Box-Behnken factorial design to find out the best formulation. For screening of three categories of polymers, six independent variables were chosen for Plackett-Burman design. Osmotic agent sodium chloride and microcrystalline cellulose, pore forming agent sodium lauryl sulphate and sucrose, and coating agent ethyl cellulose and cellulose acetate were chosen as independent variables...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/27478643/etodolac-containing-topical-niosomal-gel-formulation-development-and-evaluation
#9
Gyati Shilakari Asthana, Abhay Asthana, Davinder Singh, Parveen Kumar Sharma
The present study aimed to investigate the delivery potential of Etodolac (ETD) containing topical niosomal gel. Niosomal formulations were prepared by thin film hydration method at various ratios of cholesterol and Span 60 and were evaluated with respect to particle size, shape, entrapment efficiency, and in vitro characteristics. Dicetyl phosphate (DCP) was also added in the niosomal formulation. Mean particle size of niosomal formulation was found to be in the range of 2 μm to 4 μm. Niosomal formulation N2 (1 : 1) ratio of cholesterol and surfactant displayed good entrapment efficiency (96...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/27313895/investigation-of-diffusion-characteristics-through-microfluidic-channels-for-passive-drug-delivery-applications
#10
Marcus J Goudie, Alyssa P Ghuman, Stephanie B Collins, Ramana M Pidaparti, Hitesh Handa
Microfluidics has many drug delivery applications due to the ability to easily create complex device designs with feature sizes reaching down to the 10s of microns. In this work, three different microchannel designs for an implantable device are investigated for treatment of ocular diseases such as glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy. Devices were fabricated using polydimethylsiloxane (PDMS) and soft lithography techniques, where surface chemistry of the channels was altered using 2-[methoxy(polyethyleneoxy)propyl]trimethoxysilane (PEG-silane)...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/27313894/development-of-oral-dissolvable-films-of-diclofenac-sodium-for-osteoarthritis-using-albizia-and-khaya-gums-as-hydrophilic-film-formers
#11
Martina Aduenimaa Bonsu, Kwabena Ofori-Kwakye, Samuel Lugrie Kipo, Mariam El Boakye-Gyasi, Mary-Ann Fosu
Oral dissolvable films (ODFs) of diclofenac sodium intended for osteoarthritis were prepared using Albizia and Khaya gums as hydrophilic film formers. The physicochemical properties of the gums were characterized and the gums were used to prepare diclofenac sodium ODFs (~50 mg/4 cm(2) film) by solvent casting. The two gums showed satisfactory film forming properties. The physicomechanical properties, drug-excipient compatibility, and in vitro drug release of the films in phosphate buffer pH 6.8 were studied...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/27293896/design-and-evaluation-of-voriconazole-loaded-solid-lipid-nanoparticles-for-ophthalmic-application
#12
Anubha Khare, Inderbir Singh, Pravin Pawar, Kanchan Grover
Voriconazole is a second-generation antifungal agent with excellent broad spectrum of antifungal activity commercially available for oral and intravenous administration. Systemic administration of voriconazole is associated with side effects including visual and hepatic abnormalities. This study assessed the feasibility of using solid lipid nanoparticles for ocular delivery of voriconazole adopting stearic acid as lipidic material, tween 80 as a stabilizer, and Carbopol 934 as controlled release agent and for increasing the precorneal residence time in eye...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/27190651/poly-lactic-co-glycolic-acid-chitosan-dual-loaded-nanoparticles-for-antiretroviral-nanoformulations
#13
Faithful Makita-Chingombe, Hilliard L Kutscher, Sara L DiTursi, Gene D Morse, Charles C Maponga
Poly(lactic-co-glycolic acid) (PLGA) chitosan (CS) coated nanoparticles (NPs) were loaded with two antiretrovirals (ARVs) either lamivudine (LMV) which is hydrophilic or nevirapine (NVP) which is hydrophobic or both LMV and NVP. These ARVs are of importance in resource-limited settings, where they are commonly used in human immunodeficiency virus (HIV-1) treatment due to affordability and accessibility. NPs prepared by a water-oil-water emulsion and reduced pressure solvent evaporation technique were determined to have a positive zeta potential, a capsule-like morphology, and an average hydrodynamic diameter of 240 nm...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/26904294/peg-immobilized-keratin-for-protein-drug-sequestration-and-ph-mediated-delivery
#14
Roche C de Guzman, Sina Y Rabbany
Protein drugs like growth factors are promising therapeutics for damaged-tissue repair. Their local delivery often requires biomaterial carriers for achieving the therapeutic dose range while extending efficacy. In this study, polyethylene glycol (PEG) and keratin were crosslinked and used as sponge-like scaffolds (KTN-PEG) to absorb test proteins with different isoelectric points (pI): albumin (~5), hemoglobin (~7), and lysozyme (~11). The protein release kinetics was influenced by charge at physiological pH 7...
2016: Journal of Drug Delivery
https://www.readbyqxmd.com/read/26819758/reassessing-the-role-of-intra-arterial-drug-delivery-for-glioblastoma-multiforme-treatment
#15
REVIEW
Jason A Ellis, Matei Banu, Shaolie S Hossain, Rajinder Singh-Moon, Sean D Lavine, Jeffrey N Bruce, Shailendra Joshi
Effective treatment for glioblastoma (GBM) will likely require targeted delivery of several specific pharmacological agents simultaneously. Intra-arterial (IA) delivery is one technique for targeting the tumor site with multiple agents. Although IA chemotherapy for glioblastoma (GBM) has been attempted since the 1950s, the predicted benefits remain unproven in clinical practice. This review focuses on innovative approaches to IA drug delivery in treating GBM. Guided by novel in vitro and in vivo optical measurements, newer pharmacokinetic models promise to better define the complex relationship between background cerebral blood flow and drug injection parameters...
2015: Journal of Drug Delivery
https://www.readbyqxmd.com/read/26664749/impact-of-computerized-order-entry-to-pharmacy-interface-on-order-infusion-pump-discrepancies
#16
Rebecca A Russell, David Triscari, Kathy Murkowski, Matthew C Scanlon
Background. The ability of safety technologies to decrease errors, harm, and risk to patients has yet to be demonstrated consistently. Objective. To compare discrepancies between medication and intravenous fluid (IVF) orders and bedside infusion pump settings within a pediatric intensive care unit (PICU) before and after implementation of an interface between computerized physician order entry (CPOE) and pharmacy systems. Methods. Within a 72-bed PICU, medication and IVF orders in the CPOE system and bedside infusion pump settings were collected...
2015: Journal of Drug Delivery
https://www.readbyqxmd.com/read/26649201/investigation-of-fatty-acid-ketohydrazone-modified-liposome-s-properties-as-a-drug-carrier
#17
Keita Hayashi, Madoka Kiriishi, Keishi Suga, Yukihiro Okamoto, Hiroshi Umakoshi
pH-responsive liposomes were prepared by modifying the liposome with acid-cleaving amphiphiles. Palmitic ketohydrazone (P-KH) or stearic ketohydrazone (S-KH), composed of hydrophilic sugar headgroup and hydrophobic acyl chain, was used as a modifier of the DMPC liposome. Because the ketohydrazone group of P-KH or S-KH was cleaved at low pH conditions (<pH 5.0), the delivery of the P-KH modified liposomes was observed probably via an endocytic pathway. The membrane properties of these liposomes were characterized, focusing on the variation of both polarity (measured by Laurdan) and membrane fluidity (measured by DPH) at low pH condition...
2015: Journal of Drug Delivery
https://www.readbyqxmd.com/read/26640713/characterization-and-compatibility-studies-of-different-rate-retardant-polymer-loaded-microspheres-by-solvent-evaporation-technique-in-vitro-in-vivo-study-of-vildagliptin-as-a-model-drug
#18
Irin Dewan, Swarnali Islam, Md Sohel Rana
The present study has been performed to microencapsulate the antidiabetic drug of Vildagliptin to get sustained release of drug. The attempt of this study was to formulate and evaluate the Vildagliptin loaded microspheres by emulsion solvent evaporation technique using different polymers like Eudragit RL100, Eudragit RS100, Ethyl cellulose, and Methocel K100M. In vitro dissolution studies were carried out in 0.1 N HCl for 8 hours according to USP paddle method. The maximum and minimum drug release were observed as 92...
2015: Journal of Drug Delivery
https://www.readbyqxmd.com/read/26579235/design-and-characterization-of-buccoadhesive-liquisolid-system-of-an-antihypertensive-drug
#19
Nilesh P Kala, Divyesh H Shastri, Pragna K Shelat
Nifedipine is an antihypertensive BCS class II drug which has poor bioavailability when given orally. The objective of the present study was to increase the bioavailability of nifedipine, by formulation and evaluation of a buccoadhesive liquisolid system using magnesium aluminium silicate (Neusilin) as both carrier and coating material and dissolution media were selected based on the solubility studies. A mixture of carboxymethylcellulose sodium and carbomer was used as mucoadhesive polymers. Buccoadhesive tablets were prepared by direct compression...
2015: Journal of Drug Delivery
https://www.readbyqxmd.com/read/25861477/dosing-time-dependent-effects-of-sodium-nitroprusside-on-cerebral-renal-and-hepatic-catalase-activity-in-mice
#20
Mamane Sani, Hichem Sebai, Roberto Refinetti, Mohan Mondal, Néziha Ghanem-Boughanmi, Naceur A Boughattas, Mossadok Ben-Attia
To investigate the time dependence of sodium nitroprusside- (NPS-) induced oxidative effects, the authors study the variation of the antioxidant enzyme CAT activity in various tissues after the administration of a single 2.5 mg/kg dose of SNP or sodium chloride (NaCl 0.9%). For each of the two dosing times (1 and 13 hours after light onset, HALO, which correspond to the beginning of diurnal rest span and of nocturnal activity span of mice, resp.), brain, kidney, and liver tissues were excised from animals at 0, 1, 3, 6, 9, 12, 24, and 36 h following the drug administration and CAT activity was assayed...
2015: Journal of Drug Delivery
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