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International Journal of Molecular Imaging

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https://www.readbyqxmd.com/read/27774318/radium-223-therapy-for-patients-with-metastatic-castrate-resistant-prostate-cancer-an-update-on-literature-with-case-presentation
#1
Nghi C Nguyen, Muhammad Shah, Leonard J Appleman, Rahul Parikh, James M Mountz
Background and Purpose. Radium-223 dichloride (Xofigo®, Bayer HealthCare Pharmaceuticals Inc.) is the first α-particle emitter therapeutic agent approved by the FDA, with benefits in overall survival and delay in symptomatic skeletal event for patients with metastatic castrate-resistant prostate cancer (CRPC). Recent post hoc analyses of the phase III ALSYMPCA trial support the previously established safety profile as well as therapeutic effect and clinical outcome of Radium-223. Currently, Radium-223 is approved as a single agent therapy for metastatic CRPC...
2016: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/27563464/accuracy-of-hepatobiliary-scintigraphy-after-liver-transplantation-and-liver-resection
#2
Manuel Eckenschwiller, Hanns Ackermann, Wolf O Bechstein, Frank Grünwald
Background and Aims. Biliary complications are the most frequent complications after common liver surgeries. In this study, accuracy of hepatobiliary scintigraphy (HBS) and impact of hyperbilirubinemia were evaluated. Methods. Between November 2007 and February 2016, 131 patients underwent hepatobiliary scintigraphy after having liver surgery. 39 patients with 42 scans after LTX (n = 13) or hepatic resection (n = 26) were evaluated in the study; 27 were male, with mean age 60 years. The subjects underwent hepatobiliary scintigraphy with Tc-99m labeled Mebrofenin...
2016: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/27313888/a-pilot-study-of-18f-flt-pet-ct-in-pediatric-lymphoma
#3
Danny L Costantini, Reza Vali, Susan McQuattie, Jeffrey Chan, Angela Punnett, Shiela Weitzman, Amer Shammas, Martin Charron
We performed an observational pilot study of 18F-FLT PET/CT in pediatric lymphoma. Eight patients with equivocal 18F-FDG PET/CT underwent imaging with 18F-FLT PET/CT. No immediate adverse reactions to 18F-FLT were observed. Compared to 18F-FDG, 18F-FLT uptake was significantly higher in bone marrow and liver (18F-FLT SUV 8.6 ± 0.6 and 5.0 ± 0.3, versus 18F-FDG SUV 1.9 ± 0.1 and 3.4 ± 0.7, resp., p < 0.05). In total, 15 lesions were evaluated with average 18F-FDG and 18F-FLT SUVs of 2.6 ± 0.1 and 2.0 ± 0...
2016: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/26858844/seasonal-temperature-changes-do-not-affect-cardiac-glucose-metabolism
#4
Jukka Schildt, Antti Loimaala, Eero Hippeläinen, Päivi Nikkinen, Aapo Ahonen
FDG-PET/CT is widely used to diagnose cardiac inflammation such as cardiac sarcoidosis. Physiological myocardial FDG uptake often creates a problem when assessing the possible pathological glucose metabolism of the heart. Several factors, such as fasting, blood glucose, and hormone levels, influence normal myocardial glucose metabolism. The effect of outdoor temperature on myocardial FDG uptake has not been reported before. We retrospectively reviewed 29 cancer patients who underwent PET scans in warm summer months and again in cold winter months...
2015: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/26491562/comparison-of-folate-receptor-targeted-optical-contrast-agents-for-intraoperative-molecular-imaging
#5
Elizabeth De Jesus, Jane J Keating, Sumith A Kularatne, Jack Jiang, Ryan Judy, Jarrod Predina, Shuming Nie, Philip Low, Sunil Singhal
Background. Intraoperative imaging can identify cancer cells in order to improve resection; thus fluorescent contrast agents have emerged. Our objective was to do a preclinical comparison of two fluorescent dyes, EC17 and OTL38, which both target folate receptor but have different fluorochromes. Materials. HeLa and KB cells lines were used for in vitro and in vivo comparisons of EC17 and OTL38 brightness, sensitivity, pharmacokinetics, and biodistribution. In vivo experiments were then performed in mice. Results...
2015: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/26146568/feasibility-and-initial-performance-of-simultaneous-spect-ct-imaging-using-a-commercial-multi-modality-preclinical-imaging-system
#6
Dustin R Osborne, Derek W Austin
Multi-modality imaging provides coregistered PET-CT and SPECT-CT images; however such multi-modality workflows usually consist of sequential scans from the individual imaging components for each modality. This typical workflow may result in long scan times limiting throughput of the imaging system. Conversely, acquiring multi-modality data simultaneously may improve correlation and registration of images, improve temporal alignment of the acquired data, increase imaging throughput, and benefit the scanned subject by minimizing time under anesthetic...
2015: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/25954516/nanoparticle-enhanced-mri-scanning-to-detect-cellular-inflammation-in-experimental-chronic-renal-allograft-rejection
#7
S R Alam, G H Tse, C Stirrat, T J MacGillivray, R J Lennen, M A Jansen, D E Newby, L Marson, P A Henriksen
Objectives. We investigated whether ultrasmall paramagnetic particles of iron oxide- (USPIO-) enhanced magnetic resonance imaging (MRI) can detect experimental chronic allograft damage in a murine renal allograft model. Materials and Methods. Two cohorts of mice underwent renal transplantation with either a syngeneic isograft or allograft kidney. MRI scanning was performed prior to and 48 hours after USPIO infusion using T2(∗)-weighted protocols. R2(∗) values were calculated to indicate the degree of USPIO uptake...
2015: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/25722888/-99m-technetium-sestamibi-123-iodine-scintigraphy-is-more-accurate-than-99m-technetium-sestamibi-alone-before-surgery-for-primary-hyperparathyroidism
#8
Eeva M Ryhänen, Jukka Schildt, Ilkka Heiskanen, Mika Väisänen, Aapo Ahonen, Eliisa Löyttyniemi, Camilla Schalin-Jäntti, Matti J Välimäki
Objectives. Studies comparing outcome of single-(99m)Tc-methoxyisobutylisonitrile ((99m)Tc-sestamibi) and dual-tracer (99m)Tc-sestamibi scintigraphy in combination with (123)I before primary surgery of primary hyperparathyroidism (PHPT) are scarce. Methods. We compared (99m)Tc-sestamibi/(123)I and (99m)Tc-sestamibi in a single-centre retrospective series of 269 PHPT patients. The results were related to laboratory, surgical and histological findings. Results. (99m)Tc-sestamibi/(123)I and (99m)Tc-sestamibi were positive in 206 (76...
2015: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/25610643/ex-vivo-characterization-of-a-novel-iodine-123-labelled-aminomethylchroman-as-a-potential-agonist-ligand-for-spect-imaging-of-dopamine-d2-3-receptors
#9
Jan-Peter van Wieringen, Kora de Bruin, Henk M Janssen, P Michel Fransen, Anton G M Janssen, Peter A van Doremalen, Martin C Michel, Philip H Elsinga, Jan Booij
For imaging of dopamine D2/3 receptors, agonist tracers are favoured over antagonists because they are more sensitive to detection of dopamine release and because they may selectively label the high-affinity receptor state. We have developed novel D2/3 receptor selective agonists that can be radiolabelled with [(123)I], which label is advantageous over most other labels, such as carbon-11, as it has a longer half-life. Particularly, we considered (R) N-[7-hydroxychroman-2-yl]-methyl 4-iodobenzyl amine (compound 1) as an attractive candidate for development as it shows high binding affinity to D2/3 receptors in vitro, and here we report on the characterization of this first [(123)I]-labelled D2/3 receptor agonist radiopharmaceutical intended for SPECT imaging...
2014: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/25436147/comparison-of-99m-tc-tetrofosmin-and-99m-tc-sestamibi-uptake-in-glioma-cell-lines-the-role-of-p-glycoprotein-expression
#10
George A Alexiou, Xanthi Xourgia, Evrysthenis Vartholomatos, Spyridon Tsiouris, John A Kalef-Ezra, Andreas D Fotopoulos, Athanasios P Kyritsis
(99m)Tc-Tetrofosmin ((99m)Tc-TF) and (99m)Tc-Sestamibi ((99m)Tc-MIBI) are SPECT tracers that have been used for brain tumor imaging. Tumor's multidrug resistance phenotype, namely, P-glycoprotein (p-gp), and the multidrug resistance related proteins (MRPs) expression have been suggested to influence both tracers' uptake. In the present study we set out to compare (99m)Tc-TF and (99m)Tc-MIBI uptake in high-grade glioma cell lines and to investigate the influence of gliomas p-gp expression on both tracers' uptake...
2014: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/24829796/beneficial-effect-of-glucose-control-on-atherosclerosis-progression-in-diabetic-apoe-mice-shown-by-rage-directed-imaging
#11
Yared Tekabe, Maria Kollaros, Qing Li, Geping Zhang, Chong Li, Ann Marie Schmidt, Lynne L Johnson
Objective. Receptor for advanced glycated endproducts (RAGE) plays an important role in atherogenesis in diabetes. We imaged RAGE to investigate the effect of glucose control to suppress RAGE and reduce atherosclerosis in apolipoprotein E null (apoE(-/-)) diabetic mice. Methods and Results. Thirty-three apoE(-/-) mice received streptozotocin and 6 weeks later 15 began treatment with insulin implants. Blood glucose measurements during study averaged: 140 ± 23 mg/dL (treated) and 354 ± 14 mg/dL (untreated)...
2014: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/24800071/lyophilized-kit-for-the-preparation-of-the-pet-perfusion-agent-68-ga-maa
#12
Alejandro Amor-Coarasa, Andrew Milera, Denny Carvajal, Seza Gulec, Anthony J McGoron
Rapid developments in the field of medical imaging have opened new avenues for the use of positron emitting labeled microparticles. The radioisotope used in our research was (68)Ga, which is easy to obtain from a generator and has good nuclear properties for PET imaging. Methods. Commercially available macroaggregated albumin (MAA) microparticles were suspended in sterile saline, centrifuged to remove the free albumin and stannous chloride, relyophilized, and stored for later labeling with (68)Ga. Labeling was performed at different temperatures and times...
2014: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/24724022/longitudinal-imaging-of-cancer-cell-metastases-in-two-preclinical-models-a-correlation-of-noninvasive-imaging-to-histopathology
#13
Pavan P Adiseshaiah, Nimit L Patel, Lilia V Ileva, Joseph D Kalen, Diana C Haines, Scott E McNeil
Metastatic spread is the leading cause of death from cancer. Early detection of cancer at primary and metastatic sites by noninvasive imaging modalities would be beneficial for both therapeutic intervention and disease management. Noninvasive imaging modalities such as bioluminescence (optical), positron emission tomography (PET)/X-ray computed tomography (CT), and magnetic resonance imaging (MRI) can provide complementary information and accurately measure tumor growth as confirmed by histopathology. Methods...
2014: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/24575301/-68-ga-nota-chsg-and-99m-tc-chsg-labeled-microspheres-for-lung-perfusion-and-liver-radiomicrospheres-therapy-planning
#14
Alejandro Amor-Coarasa, Andrew Milera, Denny Carvajal, Seza Gulec, Jared Leichner, Anthony J McGoron
Fast biodegradable (12 h < half-life < 48 h) radioactive labeled microspheres are needed for PET and SPECT lung perfusion and radiomicrosphere therapy planning. An emulsion method was used to create 30.1 ±4.8  μ m size range microspheres with biodegradable Chitosan glycol (CHSg). Microspheres were characterized and labeled with (99m)Tc or (68)Ga as an alternative to MAA in perfusion PET and SPECT studies. Surface decoration of CHSg microspheres with p-SCN-Bn-NOTA was performed to increase (68)Ga  in vivo stability...
2013: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/24490068/feasibility-and-merits-of-performing-preclinical-imaging-on-clinical-radiology-and-nuclear-medicine-systems
#15
Mehmet Bilgen
Aim. Researchers have limited access to systems dedicated to imaging small laboratory animals. This paper aims to investigate the feasibility and merits of performing preclinical imaging on clinical systems. Materials and Methods. Scans were performed on rat and mouse models of diseases or injuries on four radiology systems, tomosynthesis, computed tomography (CT), positron emission tomography/computed tomography (PET-CT), and Magnetic Resonance Imaging (MRI), based on the availability at the author's institute...
2013: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/24455242/what-is-the-clinical-significance-of-fdg-unexpected-uptake-in-the-prostate-in-patients-undergoing-pet-ct-for-other-malignancies
#16
Priya Bhosale, Aparna Balachandran, Raghu Vikram, Chitra Viswanathan, Homer Macapinlac, Eric Rohren, Ramanujan Prativadi
Purpose. To determine the clinical significance of unexpected, abnormal FDG uptake in the prostate in patients undergoing FDG-PET/CT for staging of other primary malignancies without a prior history of prostate carcinoma. Methods. Retrospective search of FDG-PET/CT studies to identify patients with unexpected, abnormal FDG uptake in the prostate gland, who underwent subsequent biopsy, was performed. 26 patients were identified. Images were reviewed to determine the pattern of uptake within the prostate (focal or diffuse) and maximum standardized uptake value (SUVmax)...
2013: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/24455241/region-based-partial-volume-correction-techniques-for-pet-imaging-sinogram-implementation-and-robustness
#17
Mike Sattarivand, Jennifer Armstrong, Gregory M Szilagyi, Maggie Kusano, Ian Poon, Curtis Caldwell
Background/Purpose. Limited spatial resolution of positron emission tomography (PET) requires partial volume correction (PVC). Region-based PVC methods are based on geometric transfer matrix implemented either in image-space (GTM) or sinogram-space (GTMo), both with similar performance. Although GTMo is slower, it more closely simulates the 3D PET image acquisition, accounts for local variations of point spread function, and can be implemented for iterative reconstructions. A recent image-based symmetric GTM (sGTM) has shown improvement in noise characteristics and robustness to misregistration over GTM...
2013: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/24324884/cholinergic-depletion-in-alzheimer-s-disease-shown-by-18-f-feobv-autoradiography
#18
Maxime J Parent, Marc-Andre Bedard, Arturo Aliaga, Luciano Minuzzi, Naguib Mechawar, Jean-Paul Soucy, Esther Schirrmacher, Alexey Kostikov, Serge G Gauthier, Pedro Rosa-Neto
Rationale. Alzheimer's Disease (AD) is a neurodegenerative condition characterized in part by deficits in cholinergic basalocortical and septohippocampal pathways. [(18)F]Fluoroethoxybenzovesamicol ([(18)F]FEOBV), a Positron Emission Tomography ligand for the vesicular acetylcholine transporter (VAChT), is a potential molecular agent to investigate brain diseases associated with presynaptic cholinergic losses. Purpose. To demonstrate this potential, we carried out an [(18)F]FEOBV autoradiography study to compare postmortem brain tissues from AD patients to those of age-matched controls...
2013: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/23936648/evaluation-of-nonradiative-clinical-imaging-techniques-for-the-longitudinal-assessment-of-tumour-growth-in-murine-ct26-colon-carcinoma
#19
Johanne Seguin, Bich-Thuy Doan, Heldmuth Latorre Ossa, Lauriane Jugé, Jean-Luc Gennisson, Mickaël Tanter, Daniel Scherman, Guy G Chabot, Nathalie Mignet
Background and Objectives. To determine the most appropriate technique for tumour followup in experimental therapeutics, we compared ultrasound (US) and magnetic resonance imaging (MRI) to characterize ectopic and orthotopic colon carcinoma models. Methods. CT26 tumours were implanted subcutaneously (s.c.) in Balb/c mice for the ectopic model or into the caecum for the orthotopic model. Tumours were evaluated by histology, spectrofluorescence, MRI, and US. Results. Histology of CT26 tumour showed homogeneously dispersed cancer cells and blood vessels...
2013: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/23936647/the-influence-of-hypoxia-and-ph-on-bioluminescence-imaging-of-luciferase-transfected-tumor-cells-and-xenografts
#20
Ashraf A Khalil, Mark J Jameson, William C Broaddus, Peck Sun Lin, Seth M Dever, Sarah E Golding, Elizabeth Rosenberg, Kristoffer Valerie, Theodore D Chung
Bioluminescence imaging (BLI) is a relatively new noninvasive technology used for quantitative assessment of tumor growth and therapeutic effect in living animal models. BLI involves the generation of light by luciferase-expressing cells following administration of the substrate luciferin in the presence of oxygen and ATP. In the present study, the effects of hypoxia, hypoperfusion, and pH on BLI signal (BLS) intensity were evaluated in vitro using cultured cells and in vivo using a xenograft model in nude mice...
2013: International Journal of Molecular Imaging
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