journal
MENU ▼
Read by QxMD icon Read
search

AIDS Research and Treatment

journal
https://www.readbyqxmd.com/read/29214077/mortality-and-its-predictors-among-hiv-infected-patients-taking-antiretroviral-treatment-in-ethiopia-a-systematic-review
#1
REVIEW
Mohammed Biset Ayalew
Background: Even though the benefit of antiretroviral therapy (ART) is well established, there is a regional variation in the extent of its benefit. The aim of this review is to highlight mortality and its predictors in Ethiopian adult HIV patients who were on ART. Methods: Relevant articles were searched on PubMed and Google Scholar databases. The search terms used in different combinations were predictor/determinant/factors, mortality/death/survival, HIV, ART/HAART, and Ethiopia...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/29209538/disclosure-of-parental-hiv-status-to-children-experiences-of-adults-receiving-antiretroviral-treatment-at-an-urban-clinic-in-kampala-uganda
#2
Charles Peter Osingada, Monica Okuga, Rose Chalo Nabirye, Nelson Kaulukusi Sewankambo, Damalie Nakanjako
Limited data are available on the experiences of parental HIV disclosure to children in Uganda. We conducted a qualitative study comprising sixteen in-depth interviews and four focus group discussions with parents receiving highly active antiretroviral therapy. Analysis was done using Atlas.ti qualitative research software. Back-and-forth triangulation was done between transcripts of the in-depth interviews and focus group discussions, and themes and subthemes were developed. Barriers to parents' disclosure included perceptions that children are too young to understand what HIV infection means and fears of secondary disclosure by the children...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/29204296/quality-of-life-of-people-living-with-hiv-aids-in-the-ho-municipality-ghana-a-cross-sectional-study
#3
James Osei-Yeboah, William K B A Owiredu, Gameli Kwame Norgbe, Sylvester Yao Lokpo, Christian Obirikorang, Emmanuel Alote Allotey, John Gameli Deku, Emmanuel Akomanin Asiamah, Nana Yaw Barimah Manaphraim, Prince Senyo Kwasi Nyamadi, Edward Yiadom Boakye, Tibemponi Ntoni, Roseline Avorkliyah, Romeo Asumbasiya Aduko, Seyram Tetteh Quarshie, Maxwell Jenkins Gbemu
Quality of life (QoL) is an important component in the evaluation of the wellbeing of people living with HIV/AIDS (PLHIV). This study was aimed at evaluating the QoL of PLHIV attending the antiretroviral clinics in the Ho municipality. A cross-sectional study was conducted from January 2017 to April 2017 involving 158 purposively selected HIV-positive patients who were attending the antiretroviral clinics both in the Volta Regional Hospital and Ho Municipal Hospital. An Interviewer administered standard questionnaire (WHOQOL-HIV Bref) was used to collect information on sociodemography, medical history, and the quality of life (QoL) of the respondents...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/29201460/early-diagnosis-of-hiv-among-infants-born-to-hiv-positive-mothers-on-option-b-plus-in-kampala-uganda
#4
Jonathan Izudi, Sylvia Auma, John Bosco Alege
Introduction: Globally, there is delay in accessing early HIV diagnosis (EID) among HIV exposed infants (HEIs). With paucity of data on EID use at Kisenyi Health Center, this study assessed factors associated with EID use among HEIs (HIV exposed infants). Method: This was a cross-sectional study of 246 HIV-positive mother-baby pairs. Data was collected by structured questionnaire, double-entered in EpiData, and analyzed with STATA using multinomial logistic regression at 5% significance level...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/29158917/lipodystrophy-among-hiv-infected-patients-attending-care-and-treatment-clinics-in-dar-es-salaam
#5
Marina Njelekela, Rose Mpembeni, Alfa Muhihi, Nzovu Ulenga, Eric Aris, Deodatus Kakoko
Background: HIV infection and long-term HAART use are associated with metabolic and morphological changes. We assessed prevalence, types, and risk factors associated with lipodystrophy among HIV-infected adults attending CTC in Dar es Salaam, Tanzania. Methods: Analysis included 466 HIV-infected patients. Study protocol involved administration of structured questionnaire to collect sociodemographic and clinical information. Diagnosis of lipodystrophy was based on physician clinical assessment...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/29085677/hiv-case-management-support-service-is-associated-with-improved-cd4-counts-of-patients-receiving-care-at-the-antiretroviral-clinic-of-pantang-hospital-ghana
#6
Bismark Sarfo, Naa Ashiley Vanderpuye, Abigail Addison, Peter Nyasulu
BACKGROUND: Factors associated with individual patient-level management of HIV have received minimal attention in sub-Saharan Africa. This study determined the association between support services and cluster of differentiation 4 (CD4) counts among HIV patients attending ART clinic in Ghana. METHODOLOGY: This was a cross-sectional study involving adults with HIV recruited between 1 August 2014 and 31 January 2015. Data on support services were obtained through a closed-ended personal interview while the CD4 counts data were collected from their medical records...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/29082041/ritonavir-boosted-darunavir-plus-two-nucleoside-reverse-transcriptase-inhibitors-versus-other-regimens-for-initial-antiretroviral-therapy-for-people-with-hiv-infection-a-systematic-review
#7
REVIEW
Tatevik Balayan, Hacsi Horvath, George W Rutherford
BACKGROUND: Darunavir is a second-generation protease-inhibitor used with ritonavir (DRV/r) and two nucleoside reverse-transcriptase inhibitors as an option in first-line antiretroviral treatment (ART). METHODS: We systematically reviewed randomized controlled trials (RCTs) of DRV/r versus other regimens in patients initiating ART. We searched five bibliographic databases and other key resources. We had no language limitations. We assessed bias risk with the Cochrane tool and used GRADE to assess evidence quality...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28948049/hiv-epidemic-in-tanzania-the-possible-role-of-the-key-populations
#8
REVIEW
Bonaventura C T Mpondo, Daniel W Gunda, Semvua B Kilonzo
HIV remains a public health concern in Tanzania and other Eastern and Southern African countries. Estimates show that there were about 1.4 million people living with HIV in Tanzania in the year 2013. HIV is a generalized epidemic in Tanzania with heterosexual transmission being the main route of transmission. Recently, however, there has been growing concern on the potential role of the key populations in HIV epidemic in the country. Studies done have shown significantly higher HIV prevalence in these populations compared to the general population...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28831309/effect-of-efavirenz-on-endogenous-progesterone-concentrations-and-contraceptive-outcomes-among-ugandan-hiv-infected-women-coadministering-ethinylestradiol-levonorgestrel
#9
Grant Munkwase, Kuteesa R Bisaso, Othman Kakaire, Sarah Nanzigu
This study assessed the effect of efavirenz mid-dose plasma concentrations on mid-luteal endogenous progesterone concentrations and contraceptive outcomes among 49 HIV infected women coadministering ethinylestradiol/levonorgestrel, including 34 HIV positive women on Highly Active Antiretroviral Therapy (HAART) and 15 HAART naïve HIV infected women, purposively selected from Mulago Hospital, Uganda. A blood sample was collected once between days 20 and 22 of each woman's menstrual cycle for measuring endogenous progesterone and efavirenz concentrations by electrochemiluminescence technology and High Performance Liquid Chromatography (HPLC), respectively...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28656105/incidence-and-predictors-of-pregnancy-among-women-on-art-in-debre-markos-referral-hospital-northwest-ethiopia-a-five-year-retrospective-cohort-study
#10
Maru Meseret, Alemayehu Shimeka, Alemayehu Bekele
Globally, death of women due to HIV/AIDS related causes during pregnancy or within 42 days after pregnancy was estimated to be 37,000. In Ethiopia, 42,900 pregnant women living with HIV gave birth in the year 2011. This study was aimed to assess incidence and predictors of pregnancy among women on ART in Debre Markos Referral Hospital, Northwest Ethiopia. A retrospective cohort study was conducted using data recorded from September 2011 to August 2015. Data was extracted from February to March, 2016, from 1,239 records and analyzed using SPSS version 16...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28638661/efficacy-and-tolerability-of-tenofovir-disoproxil-fumarate-based-regimen-as-compared-to-zidovudine-based-regimens-a-systematic-review-and-meta-analysis
#11
REVIEW
Tegene Legese Dadi, Adane Teshome Kefale, Teshale Ayele Mega, Muktar Sano Kedir, Habtamu Acho Addo, Tessema Tsehay Biru
BACKGROUND: Although tenofovir (TDF)/emtricitabine (FTC)/efavirenz (EFV) and zidovudine (ZDV)/lamivudine (3TC)/efavirenz (EFV) are used as preferred first line regimen, their head-to-head comparison in terms of their efficacy and tolerability was limited. This review aimed to synthesize the best available evidence on the comparative efficacy and tolerability of the two regimens. METHODS: Seven sites and databases in addition to Google search until August 20, 2016, were searched...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28512582/factors-affecting-utilization-of-voluntary-hiv-counseling-and-testing-services-among-teachers-in-awi-zone-northwest-ethiopia
#12
Woudneh Gereme Desta, Mulusew Alemneh Sinishaw, Kelemu Dessie Bizuneh
HIV/AIDS affects the basic educational sector which is the most productive segment of the population and vital to the creation of human capital. The loss of skilled and experienced teachers due to the problem is increasingly compromising the provision of quality education in most African countries. The study was proposed to determine the magnitude of VCT utilization and assess contributing factors that affect VCT service utilization among secondary school teachers in Awi Zone. A cross-sectional study design was conducted among 588 participants in 2014...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28469942/describing-point-of-entry-into-care-and-being-lost-to-program-in-a-cohort-of-hiv-positive-pregnant-women-in-a-large-urban-centre-in-uganda
#13
Rachel Musomba, Frank Mubiru, Shadia Nakalema, Hope Mackline, Ivan Kalule, Agnes N Kiragga, Rosalind Parkes Ratanshi, Barbara Castelnuovo
Introduction. We aim to describe the time of entry into care and factors associated with being lost to program (LTP) in pregnant women on Option B Plus in an integrated HIV and antenatal care (ANC) clinic in Uganda. Methods. We included all pregnant women enrolled into the integrated HIV-ANC clinic from January 2012 to 31st July 2014, while the follow up period extended up to October 30th 2015. LTP was defined as being out of care for ≥3 months. Results. Overall 856 women were included. Only 36.4% (86/236) of the women were enrolled in the first trimester...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28465838/a-critical-review-of-the-evidence-concerning-the-hiv-latency-reversing-effect-of-disulfiram-the-possible-explanations-for-its-inability-to-reduce-the-size-of-the-latent-reservoir-in-vivo-and-the-caveats-associated-with-its-use-in-practice
#14
REVIEW
Harry D J Knights
Combination antiretroviral therapy (cART) effectively suppresses the replication of human immunodeficiency virus type 1 (HIV-1), improves immune function, and decreases the morbidity of acquired immune deficiency syndrome (AIDS). However, it is unable to eradicate the virus because it does not eliminate latently infected cells. The latent reservoir poses the major barrier to an HIV-1 cure. The "shock and kill" strategy aims to reactivate the virus and destroy latently infected cells. Many latency reversing agents (LRAs) reactivate HIV in vitro, but the absence of damaging side-effects and efficacy in vivo make disulfiram particularly promising...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28409027/male-partners-involvement-in-prevention-of-mother-to-child-transmission-of-hiv-services-in-southern-central-ethiopia-in-case-of-lemo-district-hadiya-zone
#15
Degefa Tadele Belato, Abera Beyamo Mekiso, Bayu Begashaw
Male partners' involvement is a vital issue to prevent human immunodeficiency virus (HIV) transmission from mother to child; because it is much expectable that women were more vulnerable and high risk group of population portion. Therefore, to save lives of mothers and their newborn from acquiring HIV, male partners should do their maximum endeavor regardless of any determinant factors as our results revealed its status in our study context and elsewhere at past time too.
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28409026/antiretroviral-treatment-adherence-knowledge-and-experiences-among-adolescents-and-young-adults-in-soweto-south-africa
#16
Stefanie Hornschuh, Janan Janine Dietrich, Celokuhle Tshabalala, Fatima Laher
Human immunodeficiency virus (HIV) management of adolescents and young adults (AYAs) is particularly pertinent to sub-Saharan Africa, where the pediatric HIV burden is marked. Antiretroviral treatment (ART) adherence is a major challenge for AYAs. This qualitative study explored knowledge and experiences of adherence amongst AYAs attending treatment at the Perinatal HIV Research Unit (PHRU), Soweto, South Africa. Four focus group discussions (FGDs) and eight in-depth interviews (IDIs) were conducted with HIV-infected 15-25-year-old ART recipients...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28331636/patient-experiences-of-decentralized-hiv-treatment-and-care-in-plateau-state-north-central-nigeria-a-qualitative-study
#17
Grace O Kolawole, Hannah N Gilbert, Nancin Y Dadem, Becky L Genberg, Patricia A Agaba, Prosper Okonkwo, Oche O Agbaji, Norma C Ware
Background. Decentralization of care and treatment for HIV infection in Africa makes services available in local health facilities. Decentralization has been associated with improved retention and comparable or superior treatment outcomes, but patient experiences are not well understood. Methods. We conducted a qualitative study of patient experiences in decentralized HIV care in Plateau State, north central Nigeria. Five decentralized care sites in the Plateau State Decentralization Initiative were purposefully selected...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28255456/evaluating-adherence-to-antiretroviral-therapy-using-pharmacy-refill-records-in-a-rural-treatment-site-in-south-africa
#18
George Gachara, Lufuno G Mavhandu, Elizabeth T Rogawski, Cecile Manhaeve, Pascal O Bessong
Optimal adherence to combination antiretroviral therapy (cART) is critical to maintain virologic suppression, thereby ensuring the global success of HIV treatment. We evaluated adherence to cART using pharmacy refill records and determined the adherence threshold resulting in >90% virologic suppression in a community run treatment site in South Africa. Additionally, we analysed factors associated with adherence using univariable and multivariable logistic regression models. Logistic regression was also performed to determine the relationship between adherence and virologic suppression and the adherence threshold resulting in <10% virologic failure...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28053784/cluster-randomized-controlled-study-of-sms-text-messages-for-prevention-of-mother-to-child-transmission-of-hiv-in-rural-kenya
#19
Seble G Kassaye, John Ong'ech, Martin Sirengo, Judith Kose, Lucy Matu, Peter McOdida, Rogers Simiyu, Titus Syengo, David Muthama, Rhoderick Machekano
Background. Antiretroviral medications are key for prevention of mother-to-child transmission (PMTCT) of HIV, and transmission mitigation is affected by service delivery, adherence, and retention. Methods. We conducted a cluster-randomized controlled study in 26 facilities in Nyanza, Kenya, to determine the efficacy of SMS text messages on PMTCT outcomes. The relative risk and confidence intervals were estimated at the facility level using STATA. Results. 550 women were enrolled, from June 2012 to July 2013...
2016: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28050283/analytical-performances-of-human-immunodeficiency-virus-type-1-rna-based-amplix%C3%A2-real-time-pcr-platform-for-hiv-1-rna-quantification
#20
Christian Diamant Mossoro-Kpinde, Ralph-Sydney Mboumba Bouassa, Mohammad-Ali Jenabian, Serge Tonen Wolyec, Leman Robin, Mathieu Matta, Jean de Dieu Longo, Gérard Grésenguet, Laurent Andreoletti, Laurent Bélec
Objectives. We evaluated the performances of Amplix real-time PCR platform developed by Biosynex (Strasbourg, France), combining automated station extraction (Amplix station 16 Dx) and real-time PCR (Amplix NG), for quantifying plasma HIV-1 RNA by lyophilized HIV-1 RNA-based Amplix reagents targeting gag and LTR, using samples from HIV-1-infected adults from Central African Republic. Results. Amplix real-time PCR assay showed low limit of detection (28 copies/mL), across wide dynamic range (1.4-10 log copies/mL), 100% sensitivity and 99% specificity, high reproducibility, and accuracy with mean bias < 5%...
2016: AIDS Research and Treatment
journal
journal
43457
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"