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Clinics and Research in Hepatology and Gastroenterology

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https://www.readbyqxmd.com/read/27894906/relationship-between-nr1i2-polymorphisms-and-inflammatory-bowel-disease-risk-a-systematic-review-and-meta-analysis
#1
Man-Yi Sun, Jing-Na Lin
BACKGROUND AND OBJECTIVE: Inconsistent results regarding an association between polymorphisms within the Homo sapiens nuclear receptor subfamily 1 group I member 2 (NR1I2) gene and susceptibility to inflammatory bowel disease (IBD) have been reported. A systematic review and meta-analysis was thus undertaken to determine whether NR1I2 gene polymorphisms are associated with an increased risk of IBD. METHODS: Article retrieval was performed using on-line databases, such as PubMed, Embase, CENTRAL, and WOS...
November 25, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27863926/combination-of-temsirolimus-and-adriamycin-exhibits-an-enhanced-antitumor-effect-in-hepatocellular-carcinoma
#2
Hong-Gang Kang, Bao-Zhong Wang, Jing Zhang, Mei-Rong Liu, Ying-Xue Li
OBJECTIVE: The oncogenic PI3K/Akt/mTOR pathway is frequently activated in hepatocellular carcinoma (HCC). The aim of this study is to investigate the anti-HCC effect of combination of temsirolimus, an mTOR inhibitor, and adriamycin, a routinely used drug for treating HCC. METHODS AND MATERIALS: Proliferation of HCC cells exposure to temsirolimus, adriamycin, and their combination was determined using MTT assay in vitro as well as in a nude mice model in vivo. Cell apoptosis was examined using flow cytometry...
November 15, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27863925/number-and-function-of-circulating-endothelial-progenitor-cells-in-patients-with-primary-budd-chiari-syndrome
#3
Rui Huang, Qingqiao Zhang, Qianxin Huang, Maoheng Zu, Hao Xu, Lingyu Zeng
BACKGROUND AND AIM: Primary Budd-Chiari syndrome (BCS) is associated with vascular endothelial injury. Circulating endothelial progenitor cells (EPCs) provide an endogenous mechanism to repair endothelial injury. This study investigated the levels and functionality of EPCs in patients with primary BCS. METHODS: EPCs (CD34(+)/CD133(+)/KDR(+)) were quantified in 82 patients with primary BCS (inferior vena cava type: n=19; hepatic vein type: n=22; and mixed type: n=41), 10 cirrhosis controls (CC group) and 10 age-matched healthy controls (HC group), using flow cytometry...
November 15, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27856182/aloe-vera-induced-acute-liver-injury-a-case-report-and-literature-review
#4
Lucia Parlati, Cosmin Sebastian Voican, Katy Perlemuter, Gabriel Perlemuter
Recent data suggest that herbal and dietary supplements are the second most common cause of liver injury. We herein report a case of acute liver injury in a 68-year old female caused by ingestion of Aloe vera. Upon discontinuation of the oral Aloe vera, liver function tests (LFT) returned to normal levels. Thus, it is crucial to consider the use of herbal products as causative agents of acute liver injury.
November 14, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27840032/hepatitis-c-virus-and-atherosclerosis-a-legacy-after-virologic-cure
#5
M F Bassendine, S U Nielsen, S H Bridge, D J Felmlee, D A Sheridan, C J Packard, R D Neely
Hepatitis C virus (HCV) is a major pathogen with approximately 3% of the world's population (over 170 million) infected. Epidemiological studies have shown HCV is associated with an increased risk of cardiovascular and cerebrovascular mortality as well as peripheral arterial disease. This is despite HCV inducing an ostensibly favourable lipid profile with accompanying low classical risk score for atherosclerosis (AS). We discuss possible factors involved in the aetiopathogenesis of atherosclerosis in chronic HCV and hypothesise that an important mechanism underlying the development of AS is the presence of circulating low-density immune complexes that induce an inflammatory response...
November 10, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27840031/efficacy-and-safety-of-carbon-dioxide-insufflation-versus-air-insufflation-for-endoscopic-retrograde-cholangiopancreatography-a-meta-analysis-update
#6
Wen You Zhang, Xue Pei Jiang, Lei Miao, Fei Chi Chen, Zhi Ming Huang, Xie Lin Huang
BACKGROUND AND OBJECTIVE: Endoscopic retrograde cholangiopancreatography (ERCP) is essential for visualising the biliary tree and pancreatic ducts, and carbon dioxide (CO2) insufflation during ERCP is considered an alternative technique to air insufflation for relieving post-procedural abdominal discomfort (abdominal pain and distension). The aim of the present study was to evaluate the effect of CO2 insufflation on the remission of abdominal discomfort and the potential side effects by conducting a meta-analysis...
November 10, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27838112/low-prevalence-of-dysplastic-polyps-in-patients-with-ulcerative-colitis
#7
Ido Laish, Amir Shurani, Olga Barkay, Fred Meir Konikoff, Timna Naftali
BACKGROUND AND AIMS: Patients with ulcerative colitis (UC) are prone to colorectal cancer and dysplastic polyps and also have sporadic adenomas. There is scant information, however, relating the prevalence of sporadic adenomas in UC patients compared with normal subjects. The aim of this study was to assess the prevalence of all dysplastic lesions in UC and compare the prevalence of adenomas to that in the general population. METHODS: A single-center retrospective study, in which all patients with diagnosed UC were followed during a ten-year period...
November 9, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27836485/thalidomide-is-a-therapeutic-agent-that-is-effective-in-inducing-and-maintaining-endoscopic-remission-in-adult-cd-patients
#8
Zhenhua Zhu, Mengling Li, Xu Shu, Aiping Bai, Shunhua Long, Dongsheng Liu, Nonghua Lu, Xuan Zhu, Wangdi Liao
BACKGROUND AND AIMS: Previous studies have indicated that thalidomide may be effective in achieving clinical remission and response; however, there is a lack of studies on its effect in endoscopic remission. The aim of this study was to assess the efficacy and safety of thalidomide in inducing and maintaining endoscopic remission. METHODS: A retrospective study was conducted in adult Crohn's disease (CD) patients treated with thalidomide. Patients were assessed based on their medical records...
November 8, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27839726/low-levels-of-circulating-microrna-26a-29a-as-poor-prognostic-markers-in-patients-with-hepatocellular-carcinoma-who-underwent-curative-treatment
#9
Hyo Jung Cho, Soon Sun Kim, Ji Sun Nam, Jai Keun Kim, Jei Hee Lee, Bohyun Kim, Hee Jung Wang, Bong Wan Kim, Jung-Dong Lee, Dae Yong Kang, Ji Hyun Kim, Yang Min Jae, Jae Chul Hwang, Sung Jae Shin, Kee Myung Lee, Sung Won Cho, Jae Youn Cheong
BACKGROUND/AIMS: We evaluated the prognostic implication of circulating microRNA (miR)-21, miR-26a, and miR-29a in hepatocellular carcinoma (HCC) patients who underwent curative treatment. METHODS: The study included 120 hepatitis B virus-related HCC patients who underwent hepatic resection (n=63) or radiofrequency ablation (n=57). MiR-21, miR-26a, and miR-29a expression levels in pretreatment plasma and several clinical variables were analyzed to identify prognostic bio-markers...
November 7, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27825635/angioedema-of-the-small-intestine-a-great-imitator
#10
S Alagheband, P Malet, D Katz, M Davis-Lorton
No abstract text is available yet for this article.
November 4, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27825634/obeticholic-acid-in-primary-biliary-cholangitis
#11
Serge Erlinger
In a double-blind, randomized, placebo-controlled study including 217 patients with primary biliary cholangitis, the authors show that obeticholic acid (a potent farnesoid X agonist) administered with ursodeoxycholic acid or as monotherapy significantly decreases serum alkaline phosphatase and bilirubin when compared to placebo. Pruritus (and serious adverse effects) was observed more frequently in obeticholic acid-treated patients than in controls, in spite of a decrease in serum bile acid concentration. These results are encouraging, but more studies are needed on clinical efficacy and safety before obeticholic acid can be widely recommended...
November 4, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27818187/new-evidence-supporting-the-biliary-bicarbonate-umbrella-theory
#12
M G Fernandez-Barrena, M Barcena-Varela, J M Banales
No abstract text is available yet for this article.
November 3, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27776968/downregulation-of-long-non-coding-rnas-jpx-and-xist-is-associated-with-the-prognosis-of-hepatocellular-carcinoma
#13
Weijie Ma, Haitao Wang, Wei Jing, Fuling Zhou, Lei Chang, Zhenfei Hong, Hailing Liu, Zhisu Liu, Yufeng Yuan
BACKGROUND: The expression profiles and biological relevance of long non-coding RNA XIST and its activator JPX in hepatocellular carcinoma (HCC) are not well elucidated. We measured JPX and XIST expression levels in HCC, evaluated their clinical significance in HCC progression, and verified their potential as biomarkers for diagnosing HCC. METHODS: JPX and XIST expression in 68 HCC tissues and adjacent normal tissues were evaluated by quantitative reverse transcription-PCR (qRT-PCR); their association with pathologic features and overall survival was analyzed...
October 21, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27771345/the-association-between-vitamin-d-receptor-polymorphisms-and-serum-25-hydroxyvitamin-d-levels-with-ulcerative-colitis-in-chinese-han-population
#14
Shu-Zi Zheng, Da-Guan Zhang, Hao Wu, Li-Jia Jiang, Jie Jin, Xiu-Qing Lin, Ran Ding, Yi Jiang
There is now growing evidence suggesting that Vitamin D is playing a critical role in modulating the innate and adaptive immune responses. Several polymorphisms have been identified in the vitamin D receptor (VDR) gene but their association with ulcerative colitis (UC) susceptibility remained controversy. In the current study, we examined the association between VDR polymorphisms and serum level of 25-hydroxyvitamin D [25(OH)D] with UC in Chinese Han population. Polymorphisms of FokI (rs2228570)/BsmI (rs1544410)/ApaI (rs7975232)/TaqI (rs731236) in the VDR gene were assessed in a case-control study comprising 404 UC patients and 612 controls...
October 19, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27743982/spontaneous-tumour-lysis-syndrome-in-hepatocellular-carcinoma-presenting-with-hypocalcemic-tetany-an-unusual-case-and-systematic-literature-review
#15
Roshan Agarwala, Akash Batta, Varun Suryadevera, Vivek Kumar, Vishal Sharma, Surinder Singh Rana
Tumour lysis syndrome is an oncological emergency which is usually seen following chemotherapy for rapidly proliferating haematological malignancies. Spontaneous tumour lysis syndrome is rare in solid tumour and even rarer with hepatocellular carcinoma (HCC). Tumour lysis syndrome in the setting of HCC is usually reported as a consequence of therapeutic interventions like sorafenib administration or trans-arterial chemoembolization. We report about a case of a young lady with chronic hepatitis B related HCC who developed spontaneous tumour lysis syndrome and presented with hypocalcemic tetany...
October 12, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27637474/effect-of-ceramide-1-phosphate-transfer-protein-on-intestinal-bacterial-translocation-in-severe-acute-pancreatitis
#16
Jiang Wang, Chang Li, Yingjian Jiang, Hongmei Zheng, Dehui Li, Yibo Liang, Wensheng Deng, Dianliang Zhang
BACKGROUND AND OBJECTIVE: The aim of the study was to investigate the effects of ceramide-1-phosphate transfer protein (CPTP) on the intestinal epithelial tight junction proteins in patients with severe acute pancreatitis (SAP). METHODS: Fifty patients with SAP were classified into two groups according to the presence of bacterial translocation (BT) in the blood. Thirty healthy individuals were included in the control group. The presence of BT was analyzed by polymerase chain reaction...
September 13, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27618480/stress-induced-cellular-responses-and-cell-death-mechanisms-during-inflammatory-cholangiopathies
#17
Motoko Sasaki, Yasuni Nakanuma
Various cellular responses including apoptosis, necrosis, autophagy and cellular senescence are involved in the pathogenesis of inflammatory cholangiopathies, such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and biliary atresia (BA). For example, dysregulated autophagy may play a role in abnormal expression of mitochondrial antigens and following autoimmune pathogenesis in bile duct lesions in PBC. Recently, new types of regulated cell death including necroptosis, parthanatos, pyroptosis, immunogenic cell death are the subject of numerous reports and they may play roles in pathogenesis of liver diseases, such as nonalcoholic steatohepatitis...
September 8, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27825633/survival-analysis-of-sirolimus-based-immunosuppression-in-liver-transplantation-in-patients-with-hepatocellular-carcinoma
#18
Shi-Lei Xu, Ying-Cai Zhang, Guo-Ying Wang, Qin Yang, Bo Liu, Jian Zhang, Hua Li, Gen-Shu Wang, Yang Yang, Gui-Hua Chen
AIM: To investigate the effect of a sirolimus-based immunosuppressive protocol on tumor recurrence and survival after liver transplantation (LT) in hepatocellular carcinoma (HCC) patients. METHODS: We retrospectively analyzed 142 HCC patients who underwent LT in our hospital from January 2006 to January 2012. The patients were divided into the sirolimus (SRL) group (62 cases) and non-sirolimus (control) group (80 cases). Disease-free survival (DFS) and tumor-bearing survival after tumor recurrence were compared using the Kaplan-Meier method...
December 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27743981/a-microbial-peptide-to-rescue-severe-and-fulminant-wilson-disease
#19
Serge Erlinger
Wilson disease is characterized by massive copper overload caused by a mutation of the liver-specific copper-transporting ATPase, ATP7B. Presently, liver transplantation is the only treatment available to patients with advanced or acute liver disease. In this paper, the authors describe the therapeutic effect of methanobactin, a potent bacterial copper-binding protein, in a rat model of Wilson disease, the Atp7b(-/-) rat. Their results show a marked improvement of clinical, biochemical and ultrastructural abnormalities...
December 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27720179/two-new-mutations-of-the-clmp-gene-identified-in-a-newborn-presenting-congenital-short-bowel-syndrome
#20
Lucile Gonnaud, Maria M Alves, Clara Cremillieux, Kareen Billiemaz, Sylvie Destombe, François Varlet, Manuel Lopez, Laurène Trapes, Renaud Touraine, Robert M W Hofstra, Hugues Patural
Congenital short-bowel syndrome (CSBS) is a rare neonatal pathology associated with poor prognosis and high mortality rate. We describe a newborn presenting CSBS intestinal malrotation and chronic intestinal pseudo-obstruction syndrome (CIPS), compound heterozygous for two previously unreported heterozygous mutations in Coxsackie and adenovirus receptor-like membrane protein (CLMP) gene, one in intron 1 (c.28+1G>C), the other on exon 4 (c502C>T, p.R168X). Both mutations are predicted to be pathogenic, leading to impaired splicing and the appearance of a premature stop codon, respectively...
December 2016: Clinics and Research in Hepatology and Gastroenterology
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