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Clinics and Research in Hepatology and Gastroenterology

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https://www.readbyqxmd.com/read/28416360/primary-hepatic-angiosarcoma-and-liver-transplantation-radiological-surgical-histological-findings-and-clinical-outcome
#1
M Tran Minh, A Mazzola, F Perdigao, F Charlotte, G Rousseau, F Conti
Angiosarcoma is a rare type of soft tissue sarcoma that accounts for less than 1% of all sarcomas and only 2% of all primary hepatic tumours. Thorotrast, arsenic, and vinyl chloride monomer are frequently listed as occupational exposure risks. The estimated latency is long (10-40 years) in occupational cases and very long (60 years or more) in non-occupational cases. The symptoms and CT-scan appearance of hepatic angiosarcoma (HAS) are non-specific. We present a case of a 65-year-old Caucasian male with history of cryptogenic cirrhosis, low alpha-foetoprotein levels and a single, 4-cm nodule of potential atypical hepatocellular carcinoma (no washout at MRI and CT-scan) in segment VIII...
April 14, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28416359/marital-status-is-an-independent-prognostic-factor-for-pancreatic-neuroendocrine-tumors-patients-an-analysis-of-the-surveillance-epidemiology-and-end-results-seer-database
#2
Huaqiang Zhou, Yuanzhe Zhang, Yiyan Song, Wulin Tan, Zeting Qiu, Si Li, Qinchang Chen, Shaowei Gao
BACKGROUND AND OBJECTIVES: Marital status's prognostic impact on pancreatic neuroendocrine tumors (PNET) has not been rigorously studied. We aimed to explore the relationship between marital status and outcomes of PNET. METHODS: We retrospectively investigated 2060 PNET cases between 2004 and 2010 from Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by Chi(2) test, t-test as appropriate. Kaplan-Meier methods and COX proportional hazard models were used to ascertain independent prognostic factors...
April 14, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28412192/association-analysis-of-rac1-single-nucleotide-polymorphisms-with-ulcerative-colitis
#3
LETTER
Mohammad Taher, Nasser Ebrahimi Daryani, Mona Hedayat, Mohammad Eslamian, Elham Farhadi, Mahdi Mahmoudi, Samira Shirzad, Mohammd Kazem Nouri Taromlou, Meghedi Chaharmahali, Mohammad Hossein Nicknam, Mohammad Bashashati, Nima Rezaei
No abstract text is available yet for this article.
April 12, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28412191/red-cell-distribution-width-rdw-is-associated-with-cardiovascular-disease-risk-in-crohn-s-disease
#4
LETTER
Haider Al Taii, Zaid Yaqoob, Sadeer G Al-Kindi
No abstract text is available yet for this article.
April 12, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28412190/exogenous-growth-factor-based-regenerative-therapy-in-alcoholic-cirrhosis-patients-renders-limited-effect-on-hemostatic-elements
#5
LETTER
Priyanka Saxena, Chhagan Bihari, Roshni Mirza, Ajeet Singh Bhadoria, Lovkesh Anand, Shiv K Sarin
No abstract text is available yet for this article.
April 12, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28373016/transpapillary-passage-of-a-giant-bile-duct-stone-after-endoscopic-papillary-large-balloon-dilation-and-short-term-stenting
#6
Vincent Zimmer
No abstract text is available yet for this article.
March 31, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28365139/crohn-s-colitis-development-of-a-multiplex-gene-expression-assay-comparing-mrna-levels-of-susceptibility-genes
#7
Edda Russo, Letizia Lombardelli, Francesco Giudici, Tiziana Cavalli, Ferdinando Ficari, Marilena Fazi, Stefano Scaringi, Livia Biancone, Federica Logiodice, Mariateresa Nesi, Anna Latiano, Vito Annese, Maria Gabriella Torcia, Paolo Bechi, Francesco Tonelli, Marie-Pierre Piccinni, Cecilia Malentacchi
Crohn's disease (CD) is a multifactorial immunologically mediated disease. In this study we explored, for the first time, the efficacy of the Multiplex Gene Assay technology for detecting mRNA expression profile of 24 selected CD related genes in endoscopic biopsies and surgical specimens from CD patients with colonic localization of the disease. The polymorphisms of genes most frequently associated with CD were also analysed in DNA samples from the same patients. The analysis of endoscopic samples showed increased expression of 7 genes in inflamed mucosa compared to non-inflamed mucosa and suggests the activation of the autophagy process and of a Th17 adaptive response...
March 29, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28363424/higher-pkd3-expression-in-hepatocellular-carcinoma-hcc-tissues-predicts-poorer-prognosis-for-hcc-patients
#8
Haiyun Yang, Ming Xu, Xiufang Chi, Qun Yan, Yadong Wang, Wen Xu, Kangmin Zhuang, Aimin Li, Side Liu
AIM: Protein kinase D (PKD) acts as a key mediator in several cancer development signaling pathways. The aim of this study was to investigate the clinical significance and prognostic value of PKD3 expression in hepatocellular carcinoma (HCC) patients after hepatectomy. METHODS: PKD3 mRNA and protein expression levels in tumor and matched non-tumoral (NT) tissues, HCC cell lines were evaluated by quantitative PCR (qRT-PCR), western blotting and immunohistochemical staining (IHC)...
March 28, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28359636/hepatic-perivascular-epithelioid-tumor-pecoma-a-case-report
#9
Hélder Cardoso, Marco Silva, Filipe Vilas-Boas, Rui Cunha, Joanne Lopes, José Costa Maia, Guilherme Macedo
A 37-year-old female had liver nodules found in an abdominal ultrasound scan. The radiological features were suggestive of hepatocellular adenomas, although there were some atypical findings. Two years later, one of the nodules showed dimensional progression and intralesional hemorrhage. The patient underwent a left hepatectomy and the postoperative course was uneventful. The histological exam and the immunohistochemistry were consistent with the diagnosis of PEComa. The PEComa is a mesenchymal tumor rarely described in the liver...
March 27, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28336180/an-important-intestinal-transporter-that-regulates-the-enterohepatic-circulation-of-bile-acids-and-cholesterol-homeostasis-the-apical-sodium-dependent-bile-acid-transporter-slc10a2-asbt
#10
Ling Xiao, Guoyu Pan
The enterohepatic circulation of bile acids (BAs) is governed by specific transporters expressed in the liver and the intestine and plays a critical role in the digestion of fats and oils. During this process, the majority of the BAs secreted from the liver is reabsorbed in intestinal epithelial cells via the apical sodium-dependent bile acid transporter (ASBT/SLC10A2) and then transported into the portal vein. Previous studies revealed that regulation of the ASBT involves BAs and cholesterol. In addition, abnormal ASBT expression and function might lead to some diseases associated with disorders in the enterohepatic circulation of BAs and cholesterol homeostasis, such as diarrhoea and gallstones...
March 20, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28330624/managing-pre-symptomatic-wilson-disease-in-genetic-era-more-questions-than-answers
#11
Nedim Hadžić, Maesha Deheragoda, Anil Dhawan
No abstract text is available yet for this article.
March 18, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28330599/impact-of-graft-preservation-solutions-for-liver-transplantation-on-early-cytokine-release-and-postoperative-organ-dysfunctions-a-pilot-study
#12
H Brisson, C Arbelot, A Monsel, C Parisot, M Girard, E Savier, C Vezinet, Q Lu, J-C Vaillant, J-L Golmard, G Gorochov, O Langeron, J-J Rouby
INTRODUCTION: During liver transplantation, graft ischemia-reperfusion injury leads to a systemic inflammatory response producing postoperative organ dysfunctions. The aim of this observational and prospective study was to compare the impact of Solution de conservation des organes et tissus (SCOT) 15 and University of Wisconsin (UW) preservation solutions on early cytokine release, postreperfusion syndrome and postoperative organ dysfunctions. METHODS: Thirty-seven liver transplantations were included: 21 in UW Group and 16 in SCOT 15 group...
March 15, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28291627/diagnostic-accuracy-of-osteopontin-plus-alpha-fetoprotein-in-the-hepatocellular-carcinoma-a-meta-analysis
#13
Jinwan Li, Xiaoli Chen, Meiyu Dai, Shifeng Huang, Jingfan Chen, Shengming Dai
OBJECTIVE: Osteopontin (OPN) has been reported as a potential biomarker for diagnosis of hepatocellular carcinoma (HCC) in many inconsistent results. This study demonstrates a systematic meta-analysis for the evaluation on diagnostic accuracy of serum or plasma OPN and alpha-fetoprotein (AFP) alone and combined assays for HCC. METHODS: Relevant literatures were searched in PubMed up to August 2016. The quality of each study was evaluated by QUADAS-2 (quality assessment for studies of diagnostic accuracy)...
March 10, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28291626/mus81-knockdown-sensitizes-colon-cancer-cells-to-chemotherapeutic-drugs-by-activating-chk1-pathway
#14
Fan Wu, Shu-Chao Su, Guo-Qian Tan, Lun Yan, Ting-Yue Li, Hao-Lu Zhang, Ji-Shang Yu, Bai-Lin Wang
PURPOSE: The inhibition of Mus81, a critical DNA repair gene, is recently related to the chemosensitivity of several human cancer cells such as hepatocellular carcinoma (HCC) cells. However, the role of Mus81 knockdown in chemotherapy response of colon cancer cells remains largely unknown. METHODS AND MATERIALS: The effects of Mus81 knockdown by lentivirus-mediated short hairpin RNA in sensitivity of HCT116 and LS180 colon cancer cell lines to four therapeutic drugs, including cisplatin (CDDP), were evaluated by MTT assay as well as a mouse model...
March 10, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28286056/detection-of-hbv-dna-and-antigens-in-hbsag-positive-patients-with-primary-hepatocellular-carcinoma
#15
Sha Fu, Ning Li, Peng-Cheng Zhou, Yan Huang, Rong-Rong Zhou, Xue-Gong Fan
BACKGROUND: Hepatitis B virus (HBV) markers include HBV deoxyribonucleic acid (DNA) and HBV antigens. The former involves HBV covalently closed circular DNA (cccDNA) as well as total HBV DNA, whereas the latter involves HBsAg, HBcAg, and HBx. METHODS: Samples of tumor and adjacent non-tumor liver tissue were collected from 28 HBV-associated HCC patients. Intrahepatic total HBV DNA and cccDNA were measured using the real-time PCR Taqman assay. HBV antigens in hepatocytes were detected using immunohistochemical staining...
March 9, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28286055/urinary-metabolic-profiling-and-symptomatic-uncomplicated-diverticular-disease-of-the-colon
#16
LETTER
Antonio Tursi, Paola Mastromarino, Daniela Capobianco, Walter Elisei, Alfredo Miccheli, Giulia Pratico', Marcello Picchio, Giovanni Brandimarte
No abstract text is available yet for this article.
March 9, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28286054/chromosome-region-maintenance-1-crm1-regulates-apoptosis-of-intestinal-epithelial-cells-via-p27kip1-in-crohn-s-disease
#17
Lijun Yan, Liang Wang, Jian'an Bai, Xianjing Miao, Weiwen Zeng, Xiumei Hua, Runzhou Ni, Dongmei Zhang, Qiyun Tang
OBJECTIVE: To investigate the role of chromosome region maintenance-1 (CRM1) in Crohn's disease (CD) and its potential pathological mechanisms. METHODS: The expression and distribution of CRM1 in mucosal biopsies from patients with active CD and normal controls were detected by immunohistochemistry (IHC). We established a murine model of acute colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). Western blot was performed to investigate the expression levels of CRM1, apoptotic markers (active caspase-3 and cleaved PARP), p27kip1 and p-p27ser10...
March 9, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28283328/carnosine-ameliorates-liver-fibrosis-and-hyperammonemia-in-cirrhotic-rats
#18
Akram Jamshidzadeh, Reza Heidari, Zahra Latifpour, Mohammed Mehdi Ommati, Narges Abdoli, Somayeh Mousavi, Negar Azarpira, Azita Zarei, Mahdi Zarei, Behnam Asadi, Mojgan Abasvali, Yasaman Yeganeh, Faezeh Jafari, Arastoo Saeedi, Asma Najibi, Elnaz Mardani
AIM: Chronic liver injury and cirrhosis leads to liver failure. Hyperammonemia is a deleterious consequence of liver failure. On the other hand, oxidative stress seems to play a pivotal role in the pathogenesis of liver fibrosis as well as in the cytotoxic mechanism of ammonia. There is no promising therapeutic agent against ammonia-induced complications. The present study was conducted to evaluate the role of carnosine (CA) administration on liver pathological changes, elevated plasma ammonia, and its consequent events in cirrhotic rats...
March 7, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28274596/aberrant-expression-of-deubiquitylating-enzyme-usp9x-predicts-poor-prognosis-in-gastric-cancer
#19
Xiang Fu, Wei Xie, Xiaoxue Song, Kun Wu, Linkang Xiao, Yongqiang Liu, Lei Zhang
BACKGROUND: Ubiquitin-specific peptidase 9, X-linked (USP9X), a member of deubiquitylating enzymes family, has recently been reported to be associated with a variety of cancer progression. While it functions as either oncogene or tumor suppressor in a context-dependent manner, the expression and role of USP9X in gastric cancer is largely unknown. METHODS: Sixty-eight cases of patients with gastric cancer were enrolled in this study. The expression of USP9X and MCL1 were detected by immunohistochemistry...
March 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28268093/mesocolic-micro-skip-metastasis
#20
LETTER
Luca Reggiani Bonetti, Antonio Manenti, Federica Domati, Alberto Farinetti
No abstract text is available yet for this article.
March 3, 2017: Clinics and Research in Hepatology and Gastroenterology
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