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Clinics and Research in Hepatology and Gastroenterology

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https://www.readbyqxmd.com/read/28215541/evaluation-of-a-combinational-use-of-serum-micrornas-as-biomarkers-for-liver-diseases
#1
Ping Xu, Anliang Guo, Junchi Xu, Jianer Yao, Hui Chen, Fengping Wang, Chuanwu Zhu
Circulating microRNAs (miRNA) have been widely recognized as a novel noninvasive biomarker in a variety of physiological and pathological conditions. In order to assess the sensitivity and reliability of potential miRNAs as diagnostic markers for liver disease related to viral infection, alcohol abuse, or chemical exposure, we collected serum samples from 326 participants and evaluated the single and combination diagnostic values of three serum miRNAs (miR-122, miR-125b, miR-192) compared with a conventional marker ALT...
February 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28215540/decreased-glucagon-like-peptide-1-correlates-with-abdominal-pain-in-patients-with-constipation-predominant-irritable-bowel-syndrome
#2
Zheng-Yang Li, Na Zhang, Shuang Wen, Jing Zhang, Xiu-Li Sun, Xiao-Ming Fan, Yong-Hong Sun
BACKGROUND AND OBJECTIVE: The glucagon-like peptide-1 (GLP-1) analog, ROSE-010, plays a critical role in alleviating abdominal pain in patients with irritable bowel syndrome (IBS); however, the underling mechanism is unclear. In the present study, we determined the serum GLP-1 level in patients with constipation-predominant IBS (IBS-C). The relationship between GLP-1 and abdominal pain was investigated. In addition, the expression of the GLP-1 receptor in the colon was determined. METHODS: Rectosigmoid biopsies were gathered from 38 patients with IBS-C who met the Rome III criteria, and 22 healthy controls...
February 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28215539/could-the-combination-of-nab-paclitaxel-plus-gemcitabine-salvage-metastatic-pancreatic-adenocarcinoma-after-folfirinox-failure-a-single-institutional-retrospective-analysis
#3
LETTER
Elie El Rassy, Tarek Assi, Fadi El Karak, Marwan Ghosn, Joseph Kattan
No abstract text is available yet for this article.
February 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28215538/over-90-of-cases-of-microscopic-colitis-can-be-diagnosed-by-performing-a-short-colonoscopy
#4
Gilles Macaigne, Pierre Lahmek, Christophe Locher, Jean François Boivin, Bruno Lesgourgues, Mathieu Yver, Laurent Costes, I Abd Alsamad, Joel Cucherousset, Claire Charpignon, Hélène Guyot, Bénédicte Lambaré, Jean-Michel Ghilain, Valérie Calès, Stéphanie de Montigny-Lenhardt, Guy Bellaïche, Alexandre Pariente, Stéphane Nahon
AIMS: To determinate the topographical distribution of key diagnostic histological features of lymphocytic colitis (LC) and collagenous colitis (CC) and to establish what correlations may exist between the histological findings and the causes and severity of MC. PATIENTS AND METHODS: Patients with MC were included in a prospective multicentre French study from September 2010 to October 2012. MC was diagnosed by performing total colonoscopy with multiple biopsies of the rectum and colon collected in separate jars and analyzed separately for each site (descending and sigmoid colon, transverse colon, ascending colon)...
February 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28215537/genetic-variations-of-mitochondrial-genome-modify-risk-and-prognosis-of-hepatocellular-carcinoma-patients
#5
Cheng Chen, Yanna Ba, Deyang Li, Xiaohong Du, Xin Lia, Hai Yang, Jiaze An, Jinliang Xing, Hushan Yang, Guanglong Dong, Xu Guo
BACKGROUND: Previous studies have indicated that mitochondrial genetic variations were associated with the risk of many cancers. However, there are few reports on the association between single nucleotide polymorphisms (SNPs) or haplogroups of mitochondrial DNA (mtDNA) and the risk or prognosis of hepatocellular carcinoma (HCC). METHODS: In order to investigate the predictive and prognostic role of mtDNA SNPs and haplogroups in HCC, the mitochondrial genome of 188 HCC patients and 344 healthy controls were sequenced by next generation sequencing technology...
February 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28215390/osteopathic-management-of-chronic-constipation-in-women-patients-results-of-a-pilot-study
#6
Aurélie Belvaux, Michel Bouchoucha, Robert Benamouzig
BACKGROUND AND AIMS: Constipation is a common problem in western countries. The aim of this pilot study was to determine the effectiveness of osteopathic manipulative treatment (OMT) for the treatment of constipated women with functional constipation (FC) or defeation disorders (DD). METHODS: Twenty-one constipated females referred to a tertiary center were recruited. A course of OMT, weekly for four weeks, was given. Clinical questionnaire, Bristol stool form scale and patients' subjective perception of constipation, bloating and abdominal pain, were recorded...
February 15, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28189396/hepatocellular-carcinoma-suppressor-1-promoter-hypermethylation-in-serum-a-diagnostic-and-prognostic-study-in-hepatitis-b
#7
Ming-Ming Tian, Yu-Chen Fan, Jing Zhao, Shuai Gao, Ze-Hua Zhao, Long-Yan Chen, Kai Wang
BACKGROUND: Liver cancer ranks as the second leading cause of cancer-related mortality in man worldwide, and hepatocellular carcinoma (HCC) is the most prevalent malignant neoplasm of the liver. The sensitivity of alpha-fetoprotein (AFP) as an HCC diagnostic marker for HCC diagnosis is 39-65%, and one-third patients with HCC are missed using AFP. New biomarkers are needed to diagnose HCC at an earlier stage and to individualize treatment strategies. Hepatocellular carcinoma suppressor 1 (HCCS1) is a newly identified liver tumor suppressor gene...
February 8, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28169127/th17-treg-imbalance-is-an-indicator-of-liver-cirrhosis-process-and-a-risk-factor-for-hcc-occurrence-in-hbv-patients
#8
Kun Li, Huaie Liu, Tao Guo
OBJECTIVE: To determine the impact of T helper 17 cell (Th17)/regulatory T cell (Treg) ratio imbalance on the process and prognosis of hepatitis B virus (HBV)-related liver cirrhosis. METHODS: Patients with HBV who refused to accept any therapy from were recruited from 2009 to 2014 and followed-up to August 2016. Based on a liver stiffness measurement (LSM), the patients were divided into a low LSM group and a high LSM group. After propensity score matching, 150 patients were included...
February 3, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28163072/abdominal-aortic-dissection-during-sorafenib-therapy-for-hepatocellular-carcinoma
#9
LETTER
Lin Xu, Boqing Wang, Wei Ding
No abstract text is available yet for this article.
February 2, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28161428/growth-differentiation-factor-15-promotes-cell-viability-invasion-migration-and-angiogenesis-in-human-liver-carcinoma-cell-line-hepg2
#10
Liang Wang, Yagang Liu, Wei Li, Zhe Song
AIM: This study was aimed to explore the role of growth differentiation factor 15 (GDF15) in hepatocellular carcinoma (HCC). METHODS: Human liver carcinoma cell line HepG2 was used and transfected with vector and/or short hairpin RNA (shRNA) against GDF15. Then, the transfection efficiency was ascertained by real-time reverse transcription-polymerase chain reaction (RT-PCR) and Western blot. Cell viability was measured by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyltetrazolium bromide (MTT)...
February 1, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28139382/liver-physiological-polyploidization-microrna-122-a-key-regulator
#11
Séverine Celton-Morizur, Chantal Desdouets
Polyploidy is defined as an increase in genome DNA content and is observed in all mammalian species. Polyploidy is a common characteristic of hepatocytes. Polyploidization occurs mainly during liver development, but also in adults with increasing age or due to cellular stress. During liver development, hepatocytes polyploidization occurs through cytokinesis failure leading to the genesis of binucleate hepatocytes. Recently, Hsu et al. demonstrated that miR-122 is a key regulator of hepatic binucleation. In fact, during liver development, miR-122 directly antagonizes procytokinesis targets and thus induces cytokinesis failure leading to the genesis of binucleate hepatocytes...
January 27, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28082137/sofosbuvir-in-combination-with-daclatasvir-in-liver-transplant-recipients-with-hcv-infection-a-systematic-review-and-meta-analysis
#12
Haotian Liao, Ping Tan, Zexin Zhu, Xiaokai Yan, Jiwei Huang
BACKGROUND: Studies focusing on the efficacy of SOF+DCV regimen on liver transplantation recipients with HCV infection are still limited. In the current study, we aimed to perform a systematic review and meta-analysis to evaluate the efficacy and tolerability of SOF+DCV regimen, with or without ribavirin, on post-LT setting. METHODS: A systematic literature search of various databases as well as abstracts of major liver diseases conferences was performed. Studies with SVR data in HCV infected liver transplantation recipients treated with daclatasvir/sofosbuvir regimen were included...
January 9, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28089176/inflammatory-myofibroblastic-tumor-an-unusual-hepatic-tumor-mimicking-liver-abscess
#13
Yan-Wen Jin, Fu-Yu Li, Nan-Sheng Cheng
No abstract text is available yet for this article.
January 6, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28065745/alteration-of-methyl-cpg-binding-domain-family-in-patients-with-chronic-hepatitis-b
#14
Jing Zhao, Yu-Chen Fan, Long-Yan Chen, Shuai Gao, Feng Li, Kai Wang
BACKGROUND AND OBJECTIVE: Epigenetics contributes to the outcome of chronic hepatitis B virus (HBV) infection. However, the role of methyl-CpG binding domain (MBD) family in the natural history of chronic hepatitis B (CHB) has not been demonstrated. It is aimed to investigate the dynamic expression of MBD family and assess the potential association of MBD family in the progression of CHB. METHODS: Quantitative real-time polymerase chain reaction (RT-PCR) was used to determine the mRNA levels of MBD family in peripheral blood mononuclear cells (PBMCs) from 223 patients with CHB as training cohort, 146 patients with CHB as validation cohort [immune-tolerant (IT), immune clearance (IC), non/low-replicative (LR) and HBeAg negative hepatitis (ENH)], and 14 healthy controls (HCs)...
January 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28065744/efficacy-and-safety-of-glucagon-like-peptide-1-receptor-agonists-in-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#15
Yajie Dong, Qingguo Lv, Sheyu Li, Yuan Wu, Ling Li, Juan Li, Fang Zhang, Xin Sun, Nanwei Tong
BACKGROUND AND OBJECTIVE: New drugs are urgently needed for the treatment of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). The aim of this meta-analysis was to evaluate the efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in NAFLD/NASH. METHODS: We searched the MEDLINE, Embase, and Cochrane Library Central to identify randomized controlled trials (RCTs) and observational studies that compared GLP-1RAs with a control treatment or baseline values with respect to efficacy and safety in patients with NAFLD/NASH...
January 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28065743/high-expression-of-trim11-correlates-with-poor-prognosis-in-patients-with-hepatocellular-carcinoma
#16
Yue Chen, Liang Li, Xiaoxing Qian, Yongsheng Ge, Geliang Xu
BACKGROUND: Tripartite Motif Containing 11 (TRIM11), a member of TRIM proteins is overexpressed in gliomas and lung cancer. However, the role of TRIM11 in hepatocellular carcinoma (HCC) is unknown. BASIC PROCEDURES: Herein, we aimed to investigate the expression and clinical significance role of TRIM11 in HCC. MAIN FINDING: In this study, our data showed significant higher TRIM11 in HCC tissues (n=117) than in the matched non-tumor liver (NTL) tissues (P<0...
January 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28043790/thymidylate-synthase-gene-polymorphisms-as-important-contributors-affecting-hepatocellular-carcinoma-prognosis
#17
X Wang, X Sun, X Du, F Zhou, F Yang, J Xing, G Dong, X Guo
BACKGROUND: Thymidylate synthase (TYMS), a key rate-limiting enzyme in the folate metabolism, plays essential roles in the development of several malignancies including hepatocellular carcinoma (HCC). Nonetheless, the association of the single nucleotide polymorphisms (SNPs) in TYMS gene with the prognosis of Chinese HCC patients remains unknown. METHODS: A total of 492 HCC patients who underwent surgery treatment were included in this study. Five functional SNPs (rs2847153, rs2853533, rs502396, rs523230, and rs9967368) in TYMS gene were genotyped using the iPLEX genotyping system...
December 30, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28043789/intrahepatic-upregulation-of-mrtf-a-signaling-contributes-to-increased-hepatic-vascular-resistance-in-cirrhotic-rats-with-portal-hypertension
#18
Lei Zheng, Jun Qin, Longci Sun, Liang Gui, Chihao Zhang, Yijun Huang, Wensheng Deng, An Huang, Dong Sun, Meng Luo
BACKGROUND: Portal hypertension in cirrhosis is mediated, in part, by increased intrahepatic resistance, reflecting massive structural changes associated with fibrosis and intrahepatic vasoconstriction. Activation of the Rho/MRTF/SRF signaling pathway is essential for the cellular regulatory network of fibrogenesis. The aim of this study was to investigate MRTF-A-mediated regulation of intrahepatic fibrogenesis in cirrhotic rats. METHODS: Portal hypertension was induced in rats via an injection of CCl4 oil...
December 30, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28041935/role-of-interleukin-23-in-monocyte-derived-dendritic-cells-of-hbv-related-acute-on-chronic-liver-failure-and-its-correlation-with-the-severity-of-liver-damage
#19
Suxia Bao, Jianming Zheng, Ning Li, Chong Huang, Mingquan Chen, Qi Cheng, Qian Li, Qing Lu, Mengqi Zhu, Qingxia Ling, Kangkang Yu, Shengshen Chen, Guangfeng Shi
BACKGROUND: The role of interleukin-23 (IL-23) in monocyte-derived dendritic cells (MoDCs) from hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) patients remains unclear. The aim of this study was to observe the correlation between the activation of the IL-23 signaling pathway and the prognosis of HBV-ACLF patients. MATERIALS AND METHODS: The baseline levels of serum IL-6, IL-12, IL-17, IL-23, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) from immune tolerant (IT), chronic hepatitis B (CHB), HBV-ACLF patients and healthy individuals who served as healthy controls (HCs) were analyzed using the Luminex system, whereas serum IL-23 from HBV-ACLF patients was measured by ELISA before and after treatment...
December 29, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27989689/cd40-signaling-and-hepatic-steatosis-unanticipated-links
#20
Sébastien Lepreux, Julien Villeneuve, Antoine Dewitte, Annie M Bérard, Alexis Desmoulière, Jean Ripoche
Obesity predisposes to an increased risk of nonalcoholic fatty liver disease (NAFLD). Hepatic steatosis is the key pathological feature of NAFLD and has emerged as a metabolic disorder in which innate and adaptive arms of the immune response play a central role in disease pathogenesis. Recent studies have revealed unexpected relationships between CD40 signaling and hepatic steatosis in high fat diet rodent models. CD154, the ligand of CD40, is a mediator of inflammation and controls several critical events of innate and adaptive immune responses...
December 15, 2016: Clinics and Research in Hepatology and Gastroenterology
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