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Clinics and Research in Hepatology and Gastroenterology

Wensheng Deng, Ming Duan, Binbin Qian, Yiming Zhu, Jiayun Lin, Lei Zheng, Chihao Zhang, Xiaoliang Qi, Meng Luo
AIM: NADPH oxidase (NOX)-derived reactive oxygen species (ROS) plays key roles in the development of portal hypertension (PHT) and represents a potential therapeutic method. The objective of this study was to investigate whether pharmacological inhibition of NADPH oxidase activity could ameliorate PHT in rats. METHOD: PHT model was established by partial portal vein ligation (PPVL). Rats were treated with 30 mg/kg GKT137831 (the most specific Nox1/4 inhibitor) or vehicle daily by gavage for 14 days beginning at the day of PPVL or sham operation (SO)...
November 6, 2018: Clinics and Research in Hepatology and Gastroenterology
Xiangwei Zhang, Ran An, Hao Tian, Jian Zhao
No abstract text is available yet for this article.
November 1, 2018: Clinics and Research in Hepatology and Gastroenterology
Jing Han, Ting Liu, Mei Zhang, Aimin Wang
BACKGROUNDS AND AIMS: It has been argued that the relationship between inflammatory bowel disease (IBD) and rosacea is bi-directional, but this hypothesis has not been explicitly tested. This systematic review examines the bi-directional prospective relationships between IBD and rosacea. METHODS: A comprehensive search through PubMed and EMBASE was undertaken for studies investigating the association between two mainly forms of IBD [ulcerative colitis (UC) and Crohn's disease (CD)] and rosacea published in English until Jan 2018...
October 30, 2018: Clinics and Research in Hepatology and Gastroenterology
Li-Hua Jiang, Ying-Li Hao, Jing-Wei Zhu
BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with several genomic alterations, while the viral-chemical etiology along with molecular mechanisms of HCC pathogenesis remains largely unknown. This study aimed to determine expression profile and prognostic value of HER-2/neu, STAT3 and SOCS3 in HCC. METHODS: Immunohistochemistry and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were performed to evaluate the expression of HER-2/neu, STAT3 and SOCS3 in HCC tissues and adjacent normal tissues collected from 176 HCC patients...
October 29, 2018: Clinics and Research in Hepatology and Gastroenterology
Alfredo Alberti, Gioacchino Angarano, Massimo Colombo, Antonio Craxì, Vito Di Marco, Giovanni Di Perri, Giovanni Battista Gaeta, Giuseppe Ippolito, Alessandra Mangia, Patrizio Pasqualetti
AIMS: In 2017 the Italian Drug Agency (Agenzia Italiana del Farmaco, AIFA) revised the criteria for access to therapy for patients with chronic hepatitis C as part of a three-year plan to eradicate HCV. We conducted a Delphi study to determine strategies to identify and treat patients with HCV and to develop through a shared pathway, a model to manage patient referral and optimize prescription center capacity with the overall aim of increasing access to therapy. METHODS: The process took place in two phases - Phase I (January 2017), before the criteria for treatment of HCV were revised and Phase II (May 2017) when AIFA developed a framework for the eradication of HCV infection in Italy...
October 27, 2018: Clinics and Research in Hepatology and Gastroenterology
Muhammad Adeel Rana, Bushra Ijaz, Muhammad Daud, Sommyya Tariq, Tariq Nadeem, Tayyab Husnain
The prevalence of Hepatocellular carcinoma (HCC) has been identified world-wide. Plethora of factors including chronic infection of HBV/HCV has been characterized for the development of HCC. Although the onset and progression of HCC has been linked with awry of various signaling pathways but precise mechanism, still lies under the multitude layers of curiosity. HBV is spreading with insane speed throughout the world and has been found a main culprit in HCC development after regulating the several cellular pathways including Wnt/β-catenin, Raf/MAPK, Akt and affecting cell multiplication to genomic instability...
October 27, 2018: Clinics and Research in Hepatology and Gastroenterology
Guanghua Li, Shuangjin Yu, Jianbo Xu, Xinhua Zhang, Jinning Ye, Zhao Wang, Yulong He
BACKGROUND: The prognostic value of Helicobacter pylori (H. pylori) infection in gastric cancer patients has been investigated over many years; however, the results remain inconclusive. Thus, we performed a comprehensive review of currently available evidence via a systemic meta-analysis to evaluate the effects of H. pylori infection on the prognosis of gastric cancer patients. METHODS: Studies that evaluated the prognostic value of H. pylori infection in gastric cancer were extracted in March 2016 by searching PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials...
October 22, 2018: Clinics and Research in Hepatology and Gastroenterology
Wenzhe Fan, Yanqin Wu, Mingjian Lu, Wang Yao, Wei Cui, Yue Zhao, Yu Wang, Jiaping Li
OBJECTIVES: To compare the efficacy and safety of combination iodine [131 I] metuximab infusion and transcathether arterial chemoembolization (TACE) with those of TACE-alone for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: PubMed, Cochrane Library, Embase, Web of Science, China Biology Medicine, China Science and Technology Journal Database, Wan Fang Data, and Chinese knowledge resource integrated databases were used for the literature search regarding controlled clinical trials comparing combination TACE and iodine [131 I] metuximab infusion with TACE-alone for HCC treatment before February 1, 2016...
October 19, 2018: Clinics and Research in Hepatology and Gastroenterology
Weiqiang Ju, Cheukfai Li, Chuanzhao Zhang, Dicken Shiu-Chung Ko, Dongping Wang, Ming Han, Paul M Schroder, Xiaoping Wang, Xingyuan Jiao, Linwei Wu, Qiang Tai, Anbin Hu, Yi Ma, Xiaofeng Zhu, Zhiyong Guo, Xiaoshun He
BACKGROUND: Paediatric liver allografts sometimes are allocated to adult recipients when there are no suitable paediatric recipients on the waiting list. However, debate exits regarding the reported outcomes of liver transplants using such small grafts. METHODS: Records from adult patients undergoing liver transplantation between February 2010 and January 2016 who received whole grafts from paediatric (≤ 13 years) donors or ideal deceased adult (18-35 years) donors were reviewed...
October 11, 2018: Clinics and Research in Hepatology and Gastroenterology
Haidi K Ramadan, Nahed A Makhlouf, Amal A Mahmoud, Mohamed Abd Elrhman, Muhammad Abbas El-Masry
BACKGROUND: Vitamin D plays a role in innate and acquired immunity. The risk for bacterial infections is increased in cirrhotic patients due to low levels of vitamin D. This study aimed to determine serum 25-(OH) vitamin D levels among cirrhotic patients in the presence and absence of infections and correlate this level with liver disease severity. METHODS: This cross-sectional analytic study recruited 87 hospitalised cirrhotic patients who were divided into the following groups: group with evidence of infection (45 cases) and group without infection (42 cases)...
October 11, 2018: Clinics and Research in Hepatology and Gastroenterology
Qinghai Chen, Peng Jin, Xiaoyan Ji, Haiwei Du, Junhua Lu
Selective bile duct cannulation is the prerequisite for all endoscopic biliary therapeutic interventions, but this cannot always be achieved easily. Despite advances and new developments in endoscopic accessories, selective biliary access fails in 5%-15% of cases, even in expert high volume centers. Various techniques - such as double-guidewire induced cannulation, pre-cut papillotomy or transpancreatic sphincterotomy with or without placement of a pancreatic stent - have been used to improve cannulation success rates...
October 9, 2018: Clinics and Research in Hepatology and Gastroenterology
Bruna Cherubini Alves, Juliana Paula Bruch-Bertani, Clara Belle Manfroi Galinatti, Claudia Czarnobay Garbin, Mário Reis Álvares-da-Silva, Valesca Dall'Alba
BACKGROUND: Cardiovascular disease is a major cause of death in post-liver transplantation (LT). The aim of this study was to evaluate LT patients as to the carotid intima-media thickness (CIMT) and its association with nutritional status, dietary intake, metabolic profile and cardiovascular risk factors. METHODS: In this cross-sectional study, adult patients with more than 12 months of post-transplant follow-up underwent clinical, laboratory, functional and nutritional evaluation by 3-day-diet-record, anthropometry and dynamometry...
October 6, 2018: Clinics and Research in Hepatology and Gastroenterology
Lucia Parlati, Laura Sirmai, Claire-Antoinette Dupuy, Denis Glotz, Stanislas Pol
No abstract text is available yet for this article.
October 4, 2018: Clinics and Research in Hepatology and Gastroenterology
Tong Wang, Dawei Cui, Shaoming Chen, Xujian Xu, Changgui Sun, Yuzhu Dai, Jun Cheng
BACKGROUND: During the natural hepatitis B virus (HBV) infection process, some infected subjects are characterized by a sustained low serum HBV surface antigen (HBsAg) expression level. Most members in this population are chronic asymptomatic HBV carriers (ASCs). To elucidate the mechanism underlying low-level HBsAg expression in ASCs, we sequenced the HBV S gene in these patients to reveal specific sequence characteristics. METHODS: Overall, 1308 cases of chronic ASCs were grouped according to their HBsAg serum expression levels (10 IU/mL)...
October 4, 2018: Clinics and Research in Hepatology and Gastroenterology
Chao Yu, Liqing Wang, Hongliang Xue, Hongmei Lin, Yanping Li, Sun-On Chan
BACKGROUND: Association of diabetes with non-alcoholic steatohepatitis has been well documented. However, it remains unclear whether there is an association between levels of glycated hemoglobin (HbA1c ) with severity of non-alcoholic fatty liver disease (NAFLD). This study was aimed to explore the relationship between levels of HbA1c and the risk of advanced fibrosis in patients with NAFLD. METHODS: A cross-sectional study was performed on 4826 apparently healthy Chinese, who underwent a health check between January 2015 and December 2016...
September 28, 2018: Clinics and Research in Hepatology and Gastroenterology
Zhongzhong Liu, Chin-Hui Lai, Xingjian Zhang, Jun Luo, Xiaoying Huang, Xiao Qi, Wei Wang, Zibiao Zhong, Fan Xiaoli, Ling Li, Yan Xiong, Norbert Senninger, Yanfeng Wang, Qifa Ye, Shaojun Ye
OBJECTIVE: The total hepatic ischemia/reperfusion injury (IRI) involves the fact that both liver and gut are subjected to warm ischemia, which is a complex unavoidable process encountered during liver transplantation and a serious threat to graft outcome. The ways to improve hepatic IRI are currently limited. The aim of the present study was to explore the protective effect of simvastatin on total hepatic IRI and examine the underlying mechanisms. METHODS: Male Sprague Dawley rats were subjected to total (100%) hepatic warm ischemia to induce hepatic IRI...
September 28, 2018: Clinics and Research in Hepatology and Gastroenterology
Ido Laish, Ilia Sergeev, Assaf Stein, Timna Naftali, Fred M Konikoff
BACKGROUND AND AIMS: Current post-polypectomy surveillance interval guidelines do not discriminate between 1-2 diminutive (1-5mm) and small (6-9mm) non-advanced adenomas. This study compared the risk for metachronous advanced lesions in these groups. METHODS: Patients with 1-2 diminutive, non-advanced adenomas and no further advanced lesions, and patients with no polyps at baseline colonoscopy were retrospectively analyzed to determine the rate of metachronous advanced lesions...
September 25, 2018: Clinics and Research in Hepatology and Gastroenterology
Andreas Wannhoff, Daniel N Gotthardt
Primary sclerosing cholangitis (PSC) is characterized by a chronic inflammatory process of the bile ducts of unclear aetiology. It is often complicated by cholangiocarcinoma (CCA) with a dismal prognosis. Early detection of CCA is important because treatment options for advanced disease are limited. Besides the established markers, like CA19-9, recent developments have been made using latest technologies. This review summarizes the recent advances and remaining limitations of biomarkers of CCA in PSC.
September 25, 2018: Clinics and Research in Hepatology and Gastroenterology
Alastair Baker, Nanda Kerkar, Lora Todorova, Binita M Kamath, Roderick H J Houwen
BACKGROUND AND AIMS: Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of rare genetic disorders associated with bile acid secretion or transport defects. This is the first systematic review of the epidemiology, natural history and burden of PFIC. METHODS: MEDLINE and Embase were searched for publications on PFIC prevalence, incidence or natural history, and the economic burden or health-related quality of life (HRQoL) of patients with PFIC...
September 17, 2018: Clinics and Research in Hepatology and Gastroenterology
Jordan C Brooks, Robert M Shavelle, Kate N Vavra-Musser
BACKGROUND: The prognoses widely reported for pancreatic cancer reflect the very poor survival associated with the most common histological type, exocrine adenocarcinoma. We calculated life expectancies for patients with less common pancreatic neuroendocrine tumors (PNETs), and also for the subsets of these patients who survive 1 and 5 years post-diagnosis, all of which carry a significantly better prognosis. Results for 1- and 5-year PNET survivors appear not to have been previously reported, nor have life expectancies (average long-term survival times) been given...
September 13, 2018: Clinics and Research in Hepatology and Gastroenterology
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