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Clinics and Research in Hepatology and Gastroenterology

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https://www.readbyqxmd.com/read/30236549/systematic-review-of-progressive-familial-intrahepatic-cholestasis
#1
Alastair Baker, Nanda Kerkar, Lora Todorova, Binita M Kamath, Roderick H J Houwen
BACKGROUND AND AIMS: Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of rare genetic disorders associated with bile acid secretion or transport defects. This is the first systematic review of the epidemiology, natural history and burden of PFIC. METHODS: MEDLINE and Embase were searched for publications on PFIC prevalence, incidence or natural history, and the economic burden or health-related quality of life (HRQoL) of patients with PFIC...
September 17, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30220478/life-expectancy-in-pancreatic-neuroendocrine-cancer
#2
Jordan C Brooks, Robert M Shavelle, Kate N Vavra-Musser
BACKGROUND: The prognoses widely reported for pancreatic cancer reflect the very poor survival associated with the most common histological type, exocrine adenocarcinoma. We calculated life expectancies for patients with less common pancreatic neuroendocrine tumors (PNETs), and also for the subsets of these patients who survive 1 and 5 years post-diagnosis, all of which carry a significantly better prognosis. Results for 1- and 5-year PNET survivors appear not to have been previously reported, nor have life expectancies (average long-term survival times) been given...
September 13, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30219694/diagnostic-and-prognostic-value-of-serum-l1-cell-adhesion-molecule-in-esophageal-squamous-cell-carcinoma
#3
Yi-Wei Xu, Chao-Qun Hong, Zhi-Yong Wu, Yu-Hui Peng, Li-Qiang Ran, Shi-Han Yang, Bin-Sen Huang, Xiao-Ying Liang, Hai-Lu Chen, Jian-Yi Wu, Xiu-E Xu, Jian-Wen Deng, Hai-Ying Zou, Wang-Kai Fang, En-Min Li, Li-Yan Xu, Jian-Jun Xie
OBJECTIVE: L1 cell adhesion molecule (L1CAM) has been found to be dysregulated in several types of human cancers. Here, we aimed to determine the level of soluble L1CAM in serum of patients with esophageal squamous cell carcinoma (ESCC). METHODS: Serum levels of L1CAM were determined by an enzyme-linked immunosorbent assay (ELISA) in 191 patients with ESCC and 94 normal controls. Receiver operating characteristics (ROC) was employed to calculate diagnostic accuracy...
September 12, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30219693/elevated-lactate-impairs-the-efficacy-of-antiviral-treatment-on-post-hepatectomy-survival-for-advanced-stage-hepatitis-b-virus-related-hepatocellular-carcinoma
#4
Jianping Zhao, Jingjing Wang, Songshan Chai, Yuxin Zhang, Wanguang Zhang
BACKGROUND: Nucleoside and nucleotide analogues (NAs) have a risk of mitochondrial toxicity and then inducing the increase of lactate. We aim to evaluate the impact of lactate on the effects of NAs therapy in hepatitis B virus-related hepatocellular carcinoma (HCC) patients after curative liver resection. MATERIALS AND METHODS: Five hundred and fifty-seven HBV-related HCC patients were divided into the treatment and control group according to whether they received NAs therapy or not...
September 12, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30219692/adherence-to-ursodeoxycholic-acid-therapy-in-patients-with-cholestatic-and-autoimmune-liver-disease
#5
Maria Cristina Leoni, Linde Amelung, Faydra I Lieveld, Janneke van den Brink, Joep de Bruijne, Joop E Arends, Carel-Peter van Erpecum, Karel J van Erpecum
BACKGROUND: Ursodeoxycholic acid (UDCA) is used for treatment of cholestatic liver diseases and may improve long-term outcome. Although treatment with this hydrophilic bile acid is virtually without side effects, medication adherence might be suboptimal due to patient misconceptions, compromising clinical outcome. Our aim was to evaluate adherence to UDCA in relation to patient beliefs about medicine and to identify potential predictors of poor adherence. METHODS: Prospective open-label study recruiting patients in treatment with UDCA from April 2016 to March 2017...
September 12, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30217482/the-role-of-prophylactic-gastrectomy-in-patients-with-juvenile-polyposis-syndrome
#6
LETTER
Joseph Bou Jaoude, Rachel Hallit, Elie El Rassy, Bassam Abboud
No abstract text is available yet for this article.
September 11, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30213653/snapshot-summary-of-diagnosis-and-management-of-hepatocellular-adenoma-subtypes
#7
Paulette Bioulac-Sage, Christine Sempoux, Nora Frulio, Brigitte Le Bail, Jean Frédéric Blanc, Claire Castain, Christophe Laurent, Hervé Trillaud, Laurence Chiche, Charles Balabaud
Hepatocellular adenomas (HCA) are rare benign hepatocellular tumors occurring mainly in women taking oral contraceptives with 2 major complications: severe bleeding and malignant transformation that can be avoided if nodules exceeding 5 cm are resected. This simple attitude has been challenged in the recent years with HCA in men, in young adolescent, in aged persons, and complications in hepatocellular adenomas below 5 cm. The discovery of specific mutations leading to specific phenotypes has modified the clinical spectrum of the disease...
September 10, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30195480/small-bowel-lymphangioma
#8
J M Costa, S D Carvalho, R Gonçalves, M Mascarenhas-Saraiva, J B Soares
No abstract text is available yet for this article.
September 5, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30195479/the-role-of-linear-endosonography-for-the-diagnosis-of-acute-pancreatitis-when-other-methods-failed
#9
César Vivian Lopes, Júlio Pereira-Lima, Antônio Atalíbio Hartmann
BACKGROUND AND STUDY AIMS: Acute pancreatitis has no obvious cause after clinical, laboratory and radiologic investigation in 10%-30% of patients, and the diagnosis of idiopathic pancreatitis is given. This study investigated the role of linear EUS for identification of possible causes for acute pancreatitis when other investigative methods failed. PATIENTS AND METHODS: Between June 2012 and March 2017, 35 patients [25 women; mean age: 51.9 + 17.8 years] with idiopathic acute pancreatitis underwent linear EUS for investigation...
September 5, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30174266/recurrence-of-gallbladder-carcinoma-12-years-after-laparoscopic-cholecystectomy
#10
LETTER
Fabio Carboni, Orietta Federici, Manuel Giofrè, Maria Diodoro, Mario Valle
No abstract text is available yet for this article.
August 30, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30166253/efficacy-of-ombitasvir-paritaprevir-ritonavir-ribavirin-in-management-of-hcv-genotype-4-and-end-stage-kidney-disease
#11
Mohamed A Mekky, Mohamed O Abdel-Malek, Heba A Osman, Essam M Abdel-Aziz, Abdel-Kader A Hashim, Helal F Hetta, Khairy H Morsy
BACKGROUND: Till now, pooled data about the safety and efficacy of different direct-acting antiviral (DAAs) regimens in different renal situations are still under evaluation. AIM: To evaluate a real-life experience of the efficacy and safety of ombitasvir/paritaprevir/ritonavir plus ribavirin (OBV/PTV/r plus RIB) in patients with end-stage kidney disease (ESKD). PATIENTS AND METHODS: Between January 2017 and January 2018, an open-label multicenter prospective study was designed to enroll all consecutive patients with proven CHC genotype 4 infections and concomitant ESKD based on estimated glomerular filtration rate (eGFR) with (HD group) or without hemodialysis (non-HD group)...
August 27, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30166252/answer-to-challenging-issues-in-the-management-of-wilson-s-disease
#12
LETTER
Aurélia Poujois, France Woimant
No abstract text is available yet for this article.
August 27, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30166251/marginal-zone-lymphoma-a-rare-presentation-with-multiple-intestinal-polyps
#13
Magda Zanelli, Cristiana Tioli, Maria Cecilia Mengoli, Loredana De Marco, Riccardo Valli, Maurizio Zizzo, Stefano Ascani
No abstract text is available yet for this article.
August 27, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30146236/laparoscopic-versus-open-gastrectomy-for-advanced-gastric-cancer-a-meta-analysis-based-on-high-quality-retrospective-studies-and-clinical-randomized-trials
#14
Yao Wei, Deliang Yu, Yang Li, Chaogang Fan, Guoli Li
BACKGROUND: Additional studies comparing laparoscopic gastrectomy (LG) with open gastrectomy (OG) have been published, and the meta-analysis of this subject should be improved. METHODS: Randomized controlled trials and high-quality retrospective studies, which compared LG and OG for advanced gastric cancer (AGC) treatment and were published in English and Chinese between January 2000 and February 2017, were selected through PubMed, EMBASE, and the Cochrane Library database by two reviewers independently...
August 23, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30145281/the-reasonable-drainage-option-after-laparoscopic-common-bile-duct-exploration-for-the-treatment-of-choledocholithiasis
#15
Lin-Kang Xiao, Ji-Feng Xiang, Kun Wu, Xiang Fu, Ming-You Zheng, Xiao-Xue Song, Wei Xie
OBJECTIVE: To obtain a reasonable drainage after laparoscopic common bile duct exploration (LCBDE) for the treatment of choledocholithiasis. METHODS: Data of 350 consecutive patients who underwent LCBDE in our hospital from January 2014 to December 2016 were retrospectively reviewed. All the patients were divided into three groups according to different drainage types after LCBDE, including T-tube group with 116 cases, primary closure (PC) group with 114 cases and stent insertion group with 120 cases...
August 22, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30145280/diagnosis-of-primary-biliary-cholangitis-in-a-teen-male-patient
#16
LETTER
Paolo Muratori, Marco Lenzi, Luigi Muratori
No abstract text is available yet for this article.
August 22, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30145279/collision-of-hepatocellular-nodules-in-vascular-livers-a-medical-challenge
#17
LETTER
Brigitte Le Bail, Laurence Chiche, Charles Balabaud, Paulette Bioulac-Sage
No abstract text is available yet for this article.
August 22, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30143452/cdkn2a-promoter-methylation-and-hepatocellular-carcinoma-risk-a-meta-analysis
#18
Ye Zhou, Xue-Bin Wang, Xue-Ping Qiu, Shuai Zhang, Chen Wang, Fang Zheng
AIM: Lots of studies have explored cyclin-dependent kinase inhibitor 2A (CDKN2A) promoter methylation in hepatocellular carcinoma (HCC), but the established results were controversial. Hence, we conducted the meta-analysis to comprehensively investigate the association between CDKN2A promoter methylation and HCC risk. METHODS: A comprehensive search was implemented through searching PubMed, Web of Science and Embase. Associations of CDKN2A promoter methylation with HCC risk, clinicopathological features, and CDKN2A expression were assessed by the pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs)...
August 21, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30143451/association-of-il-10-and-tgf-beta-cytokine-gene-polymorphisms-with-autoimmune-hepatitis
#19
Azizollah Yousefi, Alireza Zare Bidoki, Arezou Shafioyoun, Maryam Sadr, Farnaz Najmi Varzaneh, Mahsima Shabani, Farzaneh Motamed, Fatemeh Farahmand, Ahmad Khodadad, Gholamhossein Fallahi, Mehri Najafi, Nima Rezaei
BACKGROUND AND AIMS: Autoimmune hepatitis is a chronic immune-mediated liver injury caused by dysregulated immune response to liver antigens. Genetic susceptibility is affected by multiple single nucleotide polymorphisms in immune-related genes. There are few reports on the association of TGF-β and IL-10 genetic variants with autoimmune hepatitis. METHODS: Allele frequency and genotype status of IL-10 -1082, -819, -592 and TGF-β +869 and +915 polymorphisms were investigated in 57 unrelated patients with autoimmune hepatitis and 140 healthy controls by polymerase chain reaction with sequence-specific primers...
August 21, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/30104170/surgical-outcomes-between-patients-with-and-without-a-cirrhotic-liver-undergoing-laparoscopic-liver-resection-a-meta-analysis
#20
Chunling Wang, Zhangkan Huang, Xiaozhun Huang, Caixia Liu, Zhanzhou Lin, Xuelan Lu, Fengxiang Shi, Biao Zheng, Shuisheng Zhang, Fanyuan Wen
BACKGROUND: Laparoscopic surgery in patients with liver cirrhosis (CL) is considered to be challenging. Recent studies have shown that laparoscopic liver resection (LLR) is more beneficial of reduced operative stress and postoperative complications in patients with CL. AIM: A meta-analysis was done to review the currently available published data comparing LLR for patients with CL versus those non-cirrhosis of the liver (NCL). METHODS: The electronic databases of PubMed, Wiley, Web of Science, Embase, and the Cochrane Library were searched from date of inception to January 29, 2018...
August 10, 2018: Clinics and Research in Hepatology and Gastroenterology
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