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Clinics and Research in Hepatology and Gastroenterology

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https://www.readbyqxmd.com/read/29776875/contrast-enhanced-harmonic-endoscopic-ultrasound-a-better-choice-to-guide-eus-fni-for-insulinoma
#1
LETTER
Shanyu Qin, Yongru Liu, Junqian Chen, Haixing Jiang
No abstract text is available yet for this article.
May 15, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29773420/relations-of-gut-liver-axis-components-and-gut-microbiota-in-obese-children-with-fatty-liver-a-pilot-study
#2
LETTER
Luca Pierri, Pasquale Saggese, Salvatore Guercio Nuzio, Jacopo Troisi, Martina Di Stasi, Marco Poeta, Riccardo Savastano, Giovanna Marchese, Roberta Tarallo, Grazia Massa, Vincenzo Ciccone, Doreen Ziegenhardt, Pierpaolo Cavallo, Ina Bergheim, Alessandro Weisz, Pietro Vajro
No abstract text is available yet for this article.
May 14, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29773419/a-changing-etiologic-scenario-in-liver-transplantation-for-hepatocellular-carcinoma-in-a-multicenter-cohort-study-from-latin-america
#3
Federico Piñero, Paulo Costa, Yuri Longatto Boteon, Sergio Hoyos Duque, Sebastian Marciano, Margarita Anders, Adriana Varón, Alina Zerega, Jaime Poniachik, Alejandro Soza, Martín Padilla Machaca, Josemaría Menéndez, Rodrigo Zapata, Mario Vilatoba, Linda Muñoz, Martín Maraschio, Luis G Podestá, Lucas McCormack, Adrian Gadano, Ilka S F Fatima Boin, Parente García, Marcelo Silva
BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of hepatocellular carcinoma (HCC) and liver transplantation (LT). Our study focused on changing trends of liver related HCC etiologies during the last years in Latin America. METHODS: From a cohort of 2761 consecutive adult LT patients between 2005 and 2012 in 17 different centers, 435 with HCC were included. Different periods including years 2005-2006, 2007-2008, 2009-2010 and 2011-2012 were considered...
May 14, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29759945/diagnosis-of-local-hepatic-tuberculosis-through-next-generation-sequencing-smarter-faster-and-better
#4
Jing-Wen Ai, Yang Li, Qi Cheng, Peng Cui, Hong-Long Wu, Bin Xu, Wen-Hong Zhang
BACKGROUND: A 45-year-old man who complained of continuous fever and multiple hepatic masses was admitted to our hospital. Repeated MRI manifestations were similar while each radiological report suggested contradictory diagnosis pointing to infections or malignances respectively. Pathologic examination of the liver tissue showed no direct evidence of either infections or tumor. We performed next-generation sequencing on the liver tissue and peripheral blood to further investigate the possible etiology...
May 11, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29753731/animal-models-of-cholangiocarcinoma-what-they-teach-us-about-the-human-disease
#5
REVIEW
Massimiliano Cadamuro, Simone Brivio, Tommaso Stecca, Eleanna Kaffe, Valeria Mariotti, Chiara Milani, Romina Fiorotto, Carlo Spirli, Mario Strazzabosco, Luca Fabris
Despite recent advances, pathogenesis of cholangiocarcinoma, a highly lethal cancer, remains enigmatic. Furthermore, treatment options are still limited and often disappointing. For this reason, in the last few years there has been a mounting interest towards the generation of experimental models able to reproduce the main features associated with this aggressive behavior. Toxic and infestation-induced, genetically engineered and cell implantation rodent models have been generated, contributing to a deeper understanding of the complex cell biology of the tumor, sustained by multiple cell interactions and driven by a huge variety of molecular perturbations...
May 9, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29753730/expression-and-significance-of-peripheral-myeloid-derived-suppressor-cells-in-chronic-hepatitis-b-patients
#6
Y Lv, M Cui, Z Lv, J Lu, X Zhang, Z Zhao, Y Wang, L Gao, N M Tsuji, H Yan
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) exert their suppressive effects on multiple immune response and contribute to the development of many diseases. However, limited data is available on the involvement of MDSCs in human chronic HBV infection. OBJECTIVE: To investigate whether the progression of chronic HBV infection was associated with imbalance of MDSCs. METHODS: The percentages of MDSCs, regulatory T (Treg), Th1 and Tc1 cells in the peripheral blood from chronic hepatitis B (CHB) patients and healthy controls (HC) were determined by flow cytometry...
May 9, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29735250/systemic-adipokines-hepatokines-and-interleukin-6-in-hcv-monoinfected-and-hcv-hiv-coinfected-patients-treated-with-direct-antiviral-agents-daas
#7
LETTER
Paolo Pavone, Giulia Alfieri, Giuseppe Corano-Scheri, Claudia Pinacchio, Saeid Najafi Fard, Claudia Mascia, Tiziana Tieghi, Miriam Lichtner, Gabriella d'Ettorre, Vincenzo Vullo, Claudio Maria Mastroianni
No abstract text is available yet for this article.
May 4, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29705274/early-onset-lysosomal-acid-lipase-deficiency-presenting-as-secondary-hemophagocytic-lymphohistiocytosis-two-infants-treated-with-sebelipase-alfa
#8
Ermelinda Santos Silva, Maja Klaudel-Dreszler, Agnieska Bakuła, Teresa Oliva, Tereza Sousa, Paula Cristina Fernandes, Anna Tylki-Szymańska, Elena Kamenets, Esmeralda Martins, Piotr Socha
Two unrelated infants were diagnosed with and initially treated for hemophagocytic lymphohistiocytosis (HLH), but progressed to cholestasis and liver failure. Early onset lysosomal acid lipase deficiency (EO-LAL-D) was suspected due to lymphocytes with cytoplasmic vacuolation and/or adrenal calcifications and confirmed by enzymatic and genetic analysis. Enzyme replacement therapy with sebelipase alfa was implemented, but both children died, despite initial improvement. Since this inborn error of metabolism progresses rapidly in infants, early diagnosis is crucial, and appropriate treatment should be started as soon as possible...
April 25, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29705273/cold-snare-protrusion
#9
V Zimmer
No abstract text is available yet for this article.
April 25, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29705272/hsa-mir-93-regulates-mucin-family-gene-expression-via-wnt-%C3%AE-catenin-pathway-in-intrahepatic-stone-disease
#10
Hua Ma, Wenyi Li, Pinduan Bi, Qiang Wang, Jian Li, Bin Yang
BACKGROUND: Mucin plays an essential role in the intrahepatic stone formation, but the mechanism of mucin regulation is unclear. OBJECTIVE: To investigate the potential implication of miR-93 and WNT pathway in the regulation of intrahepatic bile duct mucin expression. METHODS: Thirty patients with or without intrahepatic bile duct stones are involved; Reverse-transcription polymerase chain reaction was performed to evaluate the expression of MUC3, MUC4, MUC5B, MUC5AC mRNA and miR-93 levels...
April 25, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29685628/antegrade-papillotome-navigation-as-a-novel-next-line-approach-for-internalization-of-percutaneous-transhepatic-biliary-drainage
#11
V Zimmer
There is an increasing rivalry between percutaneous transhepatic (PTBD) vs. endoscopic ultrasound-guided biliary drainage (EUS-BD) as rescue techniques after failed endoscopic retrograde cholangiography (ERC) access. While EUS-BD procedures hold a bright future, innovations in PTBD technique are still possible and clinically meaningful, at least so, under the a conceptual framework understanding PTBD as a bridging, anatomy-respecting technology for definitive biliary metal stenting. This, however, calls for successful PTBD internalization as a sine qua non...
April 20, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29678444/biliary-epithelium-a-neuroendocrine-compartment-in-cholestatic-liver-disease
#12
REVIEW
Laurent Ehrlich, Marinda Scrushy, Fanyin Meng, Terry C Lairmore, Gianfranco Alpini, Shannon Glaser
Hepatic fibrosis is characterized by abnormal accumulation of extracellular matrix (ECM) that can lead to ductopenia, cirrhosis, and even malignant transformation. In this review, we examine cholestatic liver diseases characterized by extensive biliary fibrosis such as primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), polycystic liver disease (PLD), and MDR2-/- and BDL mouse models. Following biliary injury, cholangiocytes, the epithelial cells that line the bile ducts, become reactive and adopt a neuroendocrine phenotype in which they secrete and respond to neurohormones and neuropeptides in an autocrine and paracrine fashion...
April 17, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29657020/helicobacter-pylori-infection-aggravates-diet-induced-nonalcoholic-fatty-liver-in-mice
#13
Cong He, Dandan Cheng, Huan Wang, Ketao Wu, Yin Zhu, Nonghua Lu
BACKGROUND: Previous epidemiological studies have suggested a link between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD), yet animal studies are lacking to elucidate this association. In this study, we evaluated the potential effects of H. pylori infection on NAFLD in mice. METHODS: We first established two strains of H. pylori infected mice model with either chow diet or high fat diet (HFD). The body and liver weight, blood glucose, serum transaminases and lipid levels and markers of hepatic inflammation were measured...
April 12, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29655526/association-between-appendectomy-and-risk-of-primary-sclerosing-cholangitis-a-systematic-review-and-meta-analysis
#14
Karn Wijarnpreecha, Panadeekarn Panjawatanan, Omar Y Mousa, Wisit Cheungpasitporn, Surakit Pungpapong, Patompong Ungprasert
BACKGROUND/OBJECTIVES: Recent epidemiologic studies have suggested that appendectomy could be a risk factor for primary sclerosing cholangitis (PSC) although the results were inconsistent. This systematic review and meta-analysis was conducted to summarize all available evidence. METHODS: A comprehensive literature review was conducted using MEDLINE and EMBASE database through January 2018 to identify all studies that reported the risk of PSC among individuals who had appendectomy versus those with no history of appendectomy...
April 11, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29655525/predictive-value-of-liver-damage-for-severe-early-complications-and-survival-after-heart-transplantation-a-retrospective-analysis
#15
Pascal Lebray, Shaida Varnous, Alina Pascale, Philippe Leger, Charles Edouard Luyt, Vlad Ratziu, Mona Munteanu, Salima Ould Amar, Dominique Thabut, Jean Chastre, Alain Pavie, Thierry Poynard, Pascal Leprince
BACKGROUND: Hepatic dysfunction is often associated with advanced heart failure. Its impact on complications following heart transplantation is not well known. We studied the influence of preoperative hepatic dysfunction on the results of heart transplantation with a specific priority access for critical patients. METHODS: Consecutive heart transplantation patients were retrospectively analyzed at listing to detect predictive factors for early complications and survival following heart transplantation...
April 11, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29650438/hepatitis-e-virus-infection-mimicking-acute-graft-rejection-in-a-liver-transplant-recipient
#16
M Allaire, C Bazille, J Selves, E Salamé, M Altieri
INTRODUCTION: In liver transplant (LT) patients, hepatitis E virus (HEV) can lead to acute liver failure, chronic hepatitis and graft cirrhosis. Few data on graft rejection associated with HEV are available and are subject to discussion. CASE REPORT: Here we report the case of a 58-year-old male patient who underwent LT in July 2015 for cirrhosis due to NASH and chronic alcohol intake complicated by hepatocellular carcinoma. LT was performed with a deceased donor isogroup and a mismatch CMV (donor+ and recipient-)...
April 10, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29650440/the-effectiveness-of-lactobacillus-reuteri-dsm-17938-as-an-adjunct-to-macrogol-in-the-treatment-of-functional-constipation-in-children-a-randomized-double-blind-placebo-controlled-multicentre-trial
#17
Agnieszka Wegner, Aleksandra Banaszkiewicz, Jaroslaw Kierkus, Piotr Landowski, Anna Korlatowicz-Bilar, Sabina Wiecek, Jaroslaw Kwiecien, Agnieszka Gawronska, Lukasz Dembinski, Grazyna Czaja-Bulsa, Piotr Socha
OBJECTIVE: Constipation is one of the most common problems among children, with a prevalence ranging from 7 to 30%. It is treated with defecation training and laxative medications. However, many patients do not respond to the standard therapy. There is, therefore, an increasing interest in probiotics for the treatment of functional constipation. STUDY DESIGN: The aim of this study was to assess the effectiveness of Lactobacillus reuteri DSM 17938 as an adjunct to macrogol in the treatment of functional, intractable constipation in children...
April 9, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29650439/aggressive-hepatocellular-carcinoma-occurring-during-direct-antiviral-therapy
#18
A Mazzola, F Perdigao, S Tripon, Y Calmus, M Wagner, F Conti
No abstract text is available yet for this article.
April 9, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29627453/role-of-circulating-tumor-dna-in-the-management-of-patients-with-colorectal-cancer
#19
Emilie Moati, Valérie Taly, Audrey Didelot, Géraldine Perkins, Hélène Blons, Julien Taieb, Pierre Laurent-Puig, Aziz Zaanan
Colorectal cancer is a major health burden with a prognosis that has been improved with the progresses in diagnosis and the advance of chemotherapy and personalized medicine. However, because of intra-tumor heterogeneity, clonal evolution and selection, tumors often develop resistance to treatments. "Liquid biopsy" is a minimally invasive method, based on analysis of tumor-specific material in peripheral blood samples of patients. Analysis of tumor specific genetic or epigenetic alterations in cell-free circulating nucleic acids may reflect the molecular heterogeneity of the underlying disease process and serial testing could allow to monitor its temporal genomic changing without using re-biopsy...
April 4, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29625925/pancreatic-and-gastric-heterotopic-tissue-presenting-as-a-symptomatic-gallbladder-mass-a-case-report-and-literature-review
#20
M Kantor, S Eiseler, J Lai, X Liu, S Hughes, A Schiller
Pancreatic and gastric heterotopia is an uncommon congenital anomaly in which gastric and/or pancreatic tissue is found outside of its anatomic location. In the majority of patients, lesions are found incidentally because they tend to be asymptomatic. However, lesions may become symptomatic when inflammation, obstruction, and bleeding occurs. Depending on tissue size and location they can harvest a landscape of nonspecific symptoms, causing a delay in diagnosis. Heterotopic tissue of either gastric or pancreatic origin have been reported in literature, however the presence of combined gastric and pancreatic heterotopic tissue is exceedingly rare...
April 3, 2018: Clinics and Research in Hepatology and Gastroenterology
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