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Clinics and Research in Hepatology and Gastroenterology

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https://www.readbyqxmd.com/read/29307516/human-hookworm-disease-enteroscopy-and-video-capsule-endoscopy-features
#1
LETTER
T Coton, M P Massoure, S Cottez, D Varvenne
No abstract text is available yet for this article.
January 4, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29307515/clinical-outcome-and-long-term-survival-of-150%C3%A2-consecutive-patients-with-pancreatic-neuroendocrine-tumors-a-comprehensive-analysis-by-the-world-health-organization-2010-grading-classification
#2
Ben-Yuan Deng, Fei Liu, Si-Neng Yin, An-Ping Chen, Lin Xu, Bo Li
BACKGROUND AND OBJECTIVE: The World Health Organization (WHO) has revised its grading system for pancreatic neuroendocrine tumors (PNETs) in 2010 into three main group, which has not been widely and comprehensively evaluated. We aimed to validate the clinical valve of this system associated with the clinical outcome and long-term survival when applied to PNETs, which were rare and heterogeneous. METHODS: We retrospectively collected and analyzed the data of 150 consecutive patients with PNETs who underwent a resection...
January 4, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29292181/marked-edema-of-colonic-stoma-after-colectomy-and-severe-pulmonary-hypertension-report-of-two-cases
#3
Daisuke Hojo, Koji Murono, Soichiro Ishihara, Manabu Kaneko, Kazuhito Sasaki, Koji Yasuda, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa, Toshiaki Watanabe
INTRODUCTION: Pulmonary hypertension (PH) is a disease with a poor prognosis and is a risk for perioperative heart and respiratory failure. Few reports exist regarding a colectomy performed in patients with PH. Herein, we report two cases of colectomy performed in patients with severe PH, accompanied with marked edema of the colonic stoma after surgery. CASE PRESENTATION: In case 1, a 54-year-old patient with sigmoid cancer and severe primary PH underwent Hartmann's operation...
December 29, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29288086/autoimmune-hepatitis-association-with-single-nucleotide-polymorphism-of-interleukin-2-but-not-interferon-gamma
#4
Azizollah Yousefi, Elham Mahmoudi, Behnoud Baradaran Noveiry, Alireza Zare Bidoki, Maryam Sadr, Farzaneh Motamed, Mehri Najafi, Fatemeh Farahmand, Ahmad Khodadad, Gholam Hossein Fallahi, Nima Rezaei
BACKGROUND: Autoimmune hepatitis (AIH) is a chronic inflammation in hepatocellular tissues associated with circulating autoantibodies. Imbalance in T-cells population and dysregulation in several cytokine profiles has been implicated in pathogenesis of AIH. This study was performed to assess potential association of AIH with interleukin-2 (IL-2) and interferon-gamma (IFN-γ) genes single nucleotide polymorphisms (SNPs). METHODS: Fifty-six patients with AIH and 139 healthy individuals were enrolled in this study...
December 26, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29279268/direct-acting-antiviral-therapy-enhances-total-cd4-and-cd8-t-cells-responses-but-does-not-alter-t-cells-activation-among-hcv-mono-infected-and-hcv-hiv-1-co-infected-patients
#5
Saeid Najafi Fard, Ivan Schietroma, Giuseppe Corano Scheri, Noemi Giustini, Sara Serafino, Eugenio Nelson Cavallari, Claudia Pinacchio, Gabriella De Girolamo, Giancarlo Ceccarelli, Carolina Scagnolari, Vincenzo Vullo, Gabriella d'Ettorre
AIM: Chronic immune activation and poor T-cell immune response are strongly associated with disease progression and pathogenesis of both hepatitis C virus (HCV) and human immunodeficiency virus (HIV)-1 infections. Little is known about the impact of anti-HCV Interferon (IFN)-free direct-acting antiviral (DAA) therapy on the systemic T-cells activation and patterns of peripheral T-cells producing pro-inflammatory cytokines. PATIENTS AND METHODS: Forty-five subjects including 18 HCV mono-infected, 17 HCV/HIV-1 co-infected patients under antiretroviral therapy (ART), and 10 healthy controls (HCs) were recruited...
December 23, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29277482/comparison-of-narrow-band-imaging-and-confocal-laser-endomicroscopy-for-the-detection-of-neoplasia-in-barrett-s-esophagus-a-meta-analysis
#6
Yi-Quan Xiong, Shu-Juan Ma, Hao-Yue Hu, Jing Ge, Li-Zhi Zhou, Shu-Ting Huo, Min Qiu, Qing Chen
AIMS: Barrett's esophagus (BE) predisposes to the development of esophageal neoplasia, including high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC). A systematic literature review and meta-analysis were performed to assess the accuracy of within-patient comparisons of narrow band imaging (NBI) and confocal laser endomicroscopy (CLE) for diagnosis of HGD/EAC in patients with BE. METHODS: The following databases were examined up to April 2016 without language restriction: PubMed, Embase, Medline, Web of Science and the Cochrane Library...
December 22, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29276096/the-association-of-variations-in-tlr-genes-and-spontaneous-immune-control-of-hepatitis-b-virus
#7
Seyma Katrinli, Adil Nigdelioglu, Kamil Ozdil, Gizem Dinler-Doganay, Levent Doganay
BACKGROUND: Toll-like receptors (TLRs) are suspected to play a critical role in liver diseases and the progression of chronic hepatitis B (CHB) infection. In this study, we investigated the possible association between TLRs and hepatitis B virus (HBV) infection chronicity in Turkish population. METHODS: TLR4 (+896 A→G) (rs4986790), TLR5 (+1846 T→C) (rs5744174) and TLR9 (-1237T→C) (rs5743836) polymorphisms were screened in 131 CHB patient and 168 individuals by polymerase chain reaction (PCR) - restriction fragment length polymorphism (RFLP) technique...
December 21, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29276095/an-ambivalent-common-bile-duct
#8
Vincent Zimmer
No abstract text is available yet for this article.
December 21, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29273278/co-expression-of-pdgf-b-and-vegfr-3-strongly-correlates-with-poor-prognosis-in-hepatocellular-carcinoma-patients-after-hepatectomy
#9
Bin Chen, Jinghua Liu, Xionghua Wang, Qian Shen, Chao Li, Chunshan Dai
BACKGROUND: The ability to evaluate the prognosis of hepatocellular carcinoma (HCC) patients following hepatectomy with biological markers is of great importance. METHODS: In this study, we collected samples from 90 patients with HCC after hepatectomy. Immunohistochemistry was used to detect the expression of PDGF-B and VEGFR-3 in these HCC samples. RESULTS: According to the immunohistochemical results, PDGF-B and VEGFR-3 staining were significantly associated with clinical features...
December 19, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29233520/5-fu-or-mitomycin-c-hepatic-arterial-infusion-after-failure-of-arterial-oxaliplatin-in-patients-with-colorectal-cancer-unresectable-liver-metastases
#10
Simon Pernot, Guillaume Velut, Rapahel Hampig Kourie, Gregory Amouyal, Marc Sapoval, Anne Laure Pointet, Bruno Landi, Yosra Zaimi, Céline Lepère, Olivier Pellerin, Julien Taieb
INTRODUCTION: Hepatic arterial infusion (HAI) chemotherapy with oxaliplatin is an accepted option in the management of colorectal cancer (CRC) with dominant liver metastases (LM). However, despite prolonged control, some patients experience disease progression. On the other hand, oxaliplatin leads to dose-limiting toxicity. In these cases, the use of a second-line HAI with an alternative drug has never been reported to date. We evaluated treatment outcomes in patients receiving second-line HAI with 5-FU or mitomycin C, after first-line HAI of oxaliplatin in heavily pretreated patients...
December 7, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29223366/therapeutic-efficacy-and-safety-of-umbilical-cord-mesenchymal-stem-cell-transplantation-for-liver-cirrhosis-in-chinese-population-a-meta-analysis
#11
Weiwei Sang, Benji Lv, Ke Li, Yan Lu
BACKGROUND AND OBJECTIVE: Mesenchymal stem cells transfusion has been considered as a promising option for liver cirrhosis (LC). The aim of this study was to systematically evaluate the efficacy and safety of umbilical cord mesenchymal stem cells (UMSC) combined with traditional supportive therapy (TST) for the treatment of patients with LC. METHODS: Data was extracted from clinical trials published on Web of Science, PubMed, EMBASE, Cochrane Library, Wanfang and CNKI database...
December 6, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29223365/performance-of-spleen-stiffness-measurement-in-prediction-of-clinical-significant-portal-hypertension-a-meta-analysis
#12
Jinzhen Song, Jianbo Huang, He Huang, Shiyu Liu, Yan Luo
AIM: Our purpose was to evaluate the correlation between spleen stiffness (SS) measured by ultrasound-based elastography and hepatic venous pressure gradient (HVPG) and assess the accuracy of SS in detecting clinical significant portal hypertension (CSPH) and severe portal hypertension. METHOD: Nine studies were included from thorough literature research and selection processes. A random model was used to analyze the correlation between HVPG and SS. We adopted the bivariate mixed effects model to assess the diagnostic performance...
December 6, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29239850/small-bowel-capsule-endoscopy-may-we-delegate-it-to-nurses
#13
Johann Dreanic, Maximilien Barret, Marion Dhooge, Marianne Gaudric, Sarah Leblanc, Vered Abitbol, Frederic Prat, Stanislas Chaussade, Romain Coriat
AIM: Small bowel capsule endoscopy (CE) is a non-invasive and validated technique allowing the visualization of the small intestine mucosa. It generated more than 40,000 images per examination and induced a long median time of medical reading that may exceed 1 hour. In a transfer of skills' program, the CE reading might be transferred to nurses. We herein evaluate and present a feasibility study of the CE to nurses. METHODS: Nurses experienced in endoscopy were trained for small bowel CE reading, selection and interpretation of pathological images...
November 24, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29239849/hepatitis-during-pregnancy-a-case-of-hemophagocytic-lymphohistiocytosis
#14
Halil Yildiz, Bernard Vandercam, Xave Thissen, Mina Komuta, Nicolas Lanthier, Frederic Debieve, Geraldine Dahlqvist
Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe and potentially fatal syndrome that can occur during pregnancy. A 36 years-old woman, at 29 weeks of gestation, presented with itchiness and jaundice since a week. On clinical examination she was apyrexial and frankly icteric. Laboratory data showed evidence of acute hepatitis. A complete work-up was made excluding viral hepatitis (HAV, HEV, HBV, HCV, HHV6, CMV, EBV) and autoimmune liver disease. Liver diseases related to pregnancy were not completely excluded...
November 24, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29175009/treatment-with-mtor-inhibitors-after-liver-transplantation-enables-a-sustained-increase-in-regulatory-t-cells-while-preserving-their-suppressive-capacity
#15
Khaldoun Ghazal, Fabien Stenard, Géraldine Dahlqvist, Clément Barjon, Lynda Aoudjehane, Olivier Scatton, Filomena Conti
BACKGROUND: The mammalian targets of rapamycin (mTOR) inhibitors (sirolimus [SRL] and everolimus [EVR]) are used after transplantation for their immunosuppressive activity. Regulatory T-cells (Tregs) play a crucial role in immune tolerance. mTOR inhibitors appear to preserve Tregs, unlike Tacrolimus (Tac). AIM: The aim of this study was to evaluate the number and function of Tregs in liver transplant recipients before and after conversion from Tac to mTOR inhibitors...
November 22, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29174380/effect-of-heme-oxygenase-1-on-the-protection-of-ischemia-reperfusion-injury-of-bile-duct-in-rats-after-liver-transplantation
#16
Xi Zhan, Zhiqing Zhang, Hanfei Huang, Yujun Zhang, Zhong Zeng
OBJECTIVE: To investigate the effect of heme oxygenase-1 (HO-1) on the ischemic reperfusion injury (IRI) of bile duct in rat models after liver transplantation. METHODS: 320 SD rats were equally and randomly divided into 5 groups, which were group A receiving injection of 3×108/pfu/ml adenovirus (adv), group B with donor receiving Adv-HO-1 and recipient receiving Adv-HO-1-siRNA, group C with donor and recipient both receiving Adv-HO-1, group D with donor receiving Adv-HO-1-siRNA and recipient receiving Adv-HO-1, and group E with donor and recipient both receiving Adv-HO-1-siRNA at 24h before liver transplantation...
November 21, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29174379/a-new-pathway-to-escape-lipotoxicity
#17
Fadila Benhamed, Catherine Postic
The molecular mechanisms underlying fatty liver progression towards more severe syndromes are complex and only partially understood. Studies have recently reported that lipotoxic fatty acid metabolites are instrumental in the development of hepatocyte injury in the context of fatty liver disease. The recent study by Papazyan et al. published in Cell Metabolism (2016;24(6):863-874) addresses this issue and reveals that rescuing de novo fatty acid synthesis (lipogenesis) through the activation of the transcription factor SREBP-1c can prevent lethality as well as severe lipotoxicity caused by a combined deficiency in lipogenesis and β-oxidation...
November 21, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29170084/serum-anti-topo48-autoantibody-as-a-biomarker-for-early-diagnosis-and-prognosis-in-patients-with-esophageal-squamous-cell-carcinoma
#18
Jian-Bo Zhang, Mei Cao, Jie Chen, Shang-Rong Ye, Ke Xie, Xu He, Xiao-Li Ma, Jia Zhang, Shang-Mian Yie
BACKGROUND AND AIM: We previously reported a novel tumor associated antigen (TTA) with molecular weight around 48kDa that is a fragment derived from human DNA-topoiomerase I (TOP1). We termed the novel TAA as TOPO48 and termed autoantibody against the TAA as anti-TOPO48 autoantibody. The aim of this study is to further investigate the clinical applications of the autoantibody in patients with esophageal squamous cell carcinomas (ESCC). METHODS: Serum levels of the anti-TOPO48 autoantibody in 112 ESCC patients, 112 age- and gender-matched healthy controls and 75 patients with esophageal benign tumors were determined by using a specific anti-TOPO48 autoantibody ELISA...
November 20, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29162460/physical-exercise-in-cirrhotic-patients-towards-prehabilitation-on-waiting-list-for-liver-transplantation-a-systematic-review-and-meta-analysis
#19
Raffaele Brustia, Eric Savier, Olivier Scatton
BACKGROUND: Early survival after Liver Transplantation (LT) is reduced among sarcopenic patients. Despite, Adapted Physical Activity (APA) before LT is rarely proposed for the risk to impair portal hypertension and its resulting complications. OBJECTIVES: To assess the effects of APA program in adults affected by End Stage Liver Disease (ESLD) on hospital stay, 1-year mortality and morbidity after LT, adverse events (Primary outcomes). Secondary outcomes were changes in VO2 peak, muscle morphology, 6minutes walking distance test (6MWD), Body Mass Index (BMI), MELD, CHILD score and Hepatic Venous Pressure Gradient (HVPG)...
November 18, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29158142/can-immunochromatographic-tests-for-detecting-helicobacter-pylori-stools-antigens-replace-urea-breath-test
#20
LETTER
José Luis Guzmán-Martín, Antonio Damián Sánchez-Capilla, José María Navarro-Marí, José Gutiérrez-Fernández
No abstract text is available yet for this article.
November 17, 2017: Clinics and Research in Hepatology and Gastroenterology
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