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Clinics and Research in Hepatology and Gastroenterology

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https://www.readbyqxmd.com/read/28645742/gastrointestinal-stromal-tumors-gist-presenting-in-the-liver-diagnostic-prognostic-and-therapeutic-issues
#1
Natacha Joyon, Jérôme Dumortier, Aude Aline-Fardin, Caroline Caramella, Pierre-Jean Valette, Jean-Yves Blay, Jean-Yves Scoazec, Peggy Dartigues
CONTEXT: Extra-gastrointestinal stromal tumors (E-GIST) presenting in the liver are exceedingly rare and raise difficult diagnostic and therapeutic challenges. METHODS: We report on two cases of liver E-GIST with different clinical presentations. We describe their clinical and imaging features, their histopathological and molecular characteristics, their treatment and their course. RESULTS: The first case was that of a 56-year-old male presenting with a 10-cm liver mass; the initial diagnosis, made in 1986 from a biopsy sample, was leiomyosarcoma; liver transplantation was performed in 1987; no extra-hepatic tumor was found; the course was uneventful until 1999, when tumor recurrence was diagnosed along the initial biopsy route; after reevaluation of available material, the definitive pathological diagnosis was GIST; imatinib treatment resulted in major response; the patient died of end-stage kidney disease 22 years after the initial diagnosis and 9 years after tumor recurrence...
June 20, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28645741/chylous-ascites-due-to-idiopathic-chronic-pancreatitis-managed-with-endoscopic-stenting
#2
Amit Kumar, Harshal S Mandavdhare, Surinder S Rana, Rajesh Gupta, Vishal Sharma
Chylous ascites is an uncommon clinical entity, which usually results from congenital or acquired abnormality in proper lymphatic flow. While the common causes are related to trauma, malignancy or tuberculosis, pancreatic disorders can occasionally result in chylous ascites. Sporadic cases of chylous ascites due to acute or chronic pancreatitis or surgery for pancreatitis have been reported. The usual management is with medium chain triglycerides (MCT), total parenteral nutrition and octreotide. We report a case of a young male with idiopathic chronic pancreatitis who presented with chylous ascites which did not respond to MCT based diet and octreotide...
June 20, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28606713/rhabdomyolysis-and-coeliac-disease-a-causal-or-casual-association-a-case-report-and-review-of-literature
#3
Claudia Mandato, Alessandro Rossi, Mariano Caldore, Marta Lamba, Michele Rocco, Renata Auricchio, Pietro Vajro, Paolo Siani
BACKGROUND: Rhabdomyolysis is a rare, potentially life-threatening condition, caused by multiple disorders. The association with Coeliac Disease (CD) has been rarely reported and in these cases muscular damage was imputed to hypokalemia. Herein we describe a new case of severe rhabdomyolysis in a child subsequently diagnosed as affected by CD, and review previous reports. CASE PRESENTATION: A 3-year-old boy was referred for diarrhea, brown urine, muscular pain/weakness, and no history of muscular trauma...
June 9, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28602798/association-between-primary-biliary-cholangitis-and-fracture-a-meta-analysis
#4
LETTER
Jian Zhao, Wei Li, Jia Cao, Caiquan Liang, Ding-Kang Yao
No abstract text is available yet for this article.
June 8, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28601592/both-men-and-women-with-functional-gastrointestinal-disorders-suffer-from-a-high-incidence-of-sexual-dysfunction
#5
LETTER
Michel Bouchoucha, Ghislain Devroede, Florence Mary, Cyriaque Bon, Bakthiar Bejou, Robert Benamouzig
No abstract text is available yet for this article.
June 7, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28601591/diagnostic-yield-of-capsule-endoscopy-in-premenopausal-and-menopausal-women-with-obscure-gastrointestinal-bleeding
#6
LETTER
Guillaume Perrod, Camille Lorenceau-Savale, Gabriel Rahmi, Christophe Cellier
No abstract text is available yet for this article.
June 7, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28601590/hepatoprotective-effects-of-ethyl-pyruvate-against-ccl4-induced-hepatic-fibrosis-via-inhibition-of-tlr4-nf-%C3%AE%C2%BAb-signaling-and-up-regulation-of-mmps-timps-ratio
#7
Mingxiao Zhang, Xiaosong Hu, Shuai Li, Chen Lu, Juan Li, Yonghua Zong, Wenqian Qi, Huijun Yang
BACKGROUND AND AIM: Liver fibrosis is a worldwide clinical issue. It has been well established that liver fibrosis is characterized of excessive extracellular matrix (ECM) deposition in chronically damaged livers. Accumulating evidences have suggested that ethyl pyruvate (EP) is a potential useful agent for preventing from hepatic injury. The aim of this study was to evaluate the protective effects of the EP against liver fibrosis induced by carbon tetrachloride (CCl4) in rats. METHOD: Rats were randomly divided into control group, CCl4 group and CCl4+EP group, which with and without EP administration...
June 7, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28595978/pseudolymphomatous-nodular-lymphoid-hyperplasia-of-small-bowel
#8
Rui Jorge Morais, Amadeu C R Nunes, Irene Gullo, Hélder Cardoso, Ana Patricia Andrade, Armando Peixoto, Elisabete Rios, Guilherme Macedo
No abstract text is available yet for this article.
June 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28583586/attenuating-pi3k-isoforms-in-pancreatic-cancer-focus-on-immune-pi3k%C3%AE
#9
C Basset, J Guillermet-Guibert
Phosphoinositide 3-kinases PI3Ks are major drug targets in oncology. Their role is far from being completely understood in pancreatic ductal adenocarcinoma. Pancreatic cancer is a dismal disease with limited therapeutic options except for surgery. We highlight here two elegant works demonstrating the role of PI3Kγ in cancer-associated macrophages applied in particular to pancreatic tumors. These data open new avenues for the use of PI3K-targetting drugs in cancer as anti-stroma therapies. Amongst the classI PI3K isoforms, PI3Kγ and PI3Kδ, are highly expressed in immune cells...
June 2, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28579003/an-unusual-cause-of-massive-hematemesis-after-treatment-with-terlipressin
#10
Héloïse Giudicelli, Dominique Thabut, Marika Rudler
No abstract text is available yet for this article.
June 1, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28579002/new-flexible-endoscopes-surprising-bacterial-colonization-post-disinfection
#11
LETTER
T Coton, W Sbai, M Beaussac, L Luciano, G Gay, E Garnotel
No abstract text is available yet for this article.
June 1, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28578939/clinical-significance-of-c-d-box-small-nucleolar-rna-u76-as-an-oncogene-and-a-prognostic-biomarker-in-hepatocellular-carcinoma
#12
Long Wu, Lei Chang, Haitao Wang, Weijie Ma, Qin Peng, Yufeng Yuan
BACKGROUND: Recent evidence has suggested novel roles of small nucleolar RNAs (snoRNAs) in tumorigenicity. However, the roles of C/D box snoRNA U76 (SNORD76) in the development of hepatocellular carcinoma (HCC) remain unknown. Herein, we systematically evaluated dysregulation of snoRNAs in HCC and clarified the biomarker potential and biological significance of SNORD76 in HCC. METHODS: We performed quantitative analyses of the expression of SNORD76 in 66 HCC specimens to compare its expression pattern between tumor tissue and matched non-tumor tissue...
May 31, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28578938/overexpression-of-nedd9-promotes-cell-invasion-and-metastasis-in-hepatocellular-carcinoma
#13
Senjun Zhou, Ming Xu, Jiliang Shen, Xiaolong Liu, Mingming Chen, Xiujun Cai
Neural precursor cell expressed, developmentally downregulated 9 (NEDD9), is a focal adhesion scaffold protein which has been associated with metastasis in several cancers. Recent study found that NEDD9 expression was upregulated in HCC. However, the precise function of NEDD9 in HCC is still unclear. In the present study, we demonstrated that high NEDD9 expression was associated with the invasiveness of HCC in clinical samples. Moreover, by gain-and-loss function studies, we revealed that silencing of NEDD9 expression inhibited cancer cells proliferation, migration and invasion, while upregulated expression of NEDD9 promoted invasion and metastasis of HCC cells in vitro and in vivo...
May 31, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28578937/active-hcv-infection-is-associated-with-increased-circulating-levels-of-interferon-gamma-ifn-%C3%AE-inducible-protein-10-ip-10-soluble-cd163-and-inflammatory-monocytes-regardless-of-liver-fibrosis-and-hiv-coinfection
#14
Claudia Mascia, Miriam Lichtner, Paola Zuccalà, Serena Vita, Tiziana Tieghi, Raffaella Marocco, Stefano Savinelli, Raffaella Rossi, Marco Iannetta, Michela Campagna, Francesco Schiavone, Fabio Mengoni, Gianluca Russo, Claudio Maria Mastroianni, Vincenzo Vullo
BACKGROUND AND OBJECTIVE: Interferon-gamma (IFN-γ)-inducible protein-10 (IP-10), soluble (s) CD163 and sCD14 play an important role in the pathogenesis of HCV and HIV infection and are involved in inflammation and liver fibrosis. The aim of the present study was to evaluate at a single time point, plasma soluble biomarkers and inflammatory monocytes subsets in different groups of subjects: (i) HIV monoinfected patients on suppressive ART; (ii) HIV/HCV coinfected patients on ART, with undetectable HIV viremia (including either subjects who had active HCV replication or those who cleared HCV); (iii) HCV monoinfected individual with active viral replication...
May 31, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28578936/a-case-of-esophageal-tuberculosis-with-unusual-endoscopic-feature
#15
Yi-Xuan Li, Wei-Dong Nian, Hua-Hong Wang
A 59-year-old man experienced epigastric pain and an upper gastrointestinal endoscopy revealed a bulging lesio n 0.5×0.6cm in size in the middle esophagus. EUS showed a homogenous hypoechoic lesion, which interrupted the five layers structure of esophageal wall. Biopsies revealed epithelioid granuloma with central caseous necrosis and several acid-fast bacilli.
May 31, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28571919/conventional-esophageal-manometry-in-clinical-practice-current-impact-of-its-use-on-patient-management
#16
LETTER
Armando Peixoto, Rui Morais, Marco Silva, Rosa Ramalho, Guilherme Macedo
No abstract text is available yet for this article.
May 29, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28571918/colonic-polypoid-mucosa-associated-lymphoid-tissue-lymphoma
#17
Tao Chen, Yuan Ji, Li-Qing Yao, Mei-Dong Xu, Ping-Hong Zhou
No abstract text is available yet for this article.
May 29, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28566131/autoantibodies-in-antimithocondrial-antibodies-negative-primary-biliary-cholangitis
#18
LETTER
Paolo Muratori, Luigi Muratori
No abstract text is available yet for this article.
May 26, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28552432/probiotics-in-helicobacter%C3%A2-pylori-eradication-therapy-systematic-review-and-network-meta-analysis
#19
Fan Wang, Juerong Feng, Pengfei Chen, Xiaoping Liu, Minxing Ma, Rui Zhou, Ying Chang, Jing Liu, Jin Li, Qiu Zhao
BACKGROUND: Several probiotics were effective in the eradication treatment for Helicobacter pylori (Hp), but their comparative efficacy was unknown. AIM: To compare the efficacy of different probiotics when supplemented in Hp eradication therapy. METHODS: A comprehensive search was conducted to identify all relevant studies in multiple databases and previous meta-analyses. Bayesian network meta-analysis was performed to combine direct and indirect evidence and estimate the relative effects...
May 25, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28526245/lymphogenous-metastasis-to-the-transverse-colon-that-originated-from-signet-ring-cell-gastric-cancer-a-case-report-and-review-of-the-literature
#20
Hirofumi Sonoda, Kazushige Kawai, Hironori Yamaguchi, Koji Murono, Manabu Kaneko, Takeshi Nishikawa, Kensuke Otani, Kazuhito Sasaki, Koji Yasuda, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Hiroaki Nozawa, Soichiro Ishihara, Susumu Aikou, Hiroharu Yamashita, Tetsuo Ushiku, Yasuyuki Seto, Masashi Fukayama, Toshiaki Watanabe
Metastases to the colon are rare and a high-frequency primary region is the stomach. In cases of metastases to the colon, the morphological type of the metastatic region is mostly the infiltrating type of poorly differentiated or undifferentiated adenocarcinoma with lymph and blood vessel invasion. A case of cancer metastasis to the transverse colon that originated from advanced gastric cancer, which shows the difficulties in the precise diagnosis of metastases to the colon, is presented. In the present case, the gastric carcinoma was determined to be an advanced infiltrative ulcerative adenocarcinoma and the colon carcinoma was determined to be a superficial depressed adenocarcinoma...
May 16, 2017: Clinics and Research in Hepatology and Gastroenterology
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