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Clinics and Research in Hepatology and Gastroenterology

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https://www.readbyqxmd.com/read/28082137/sofosbuvir-in-combination-with-daclatasvir-in-liver-transplant-recipients-with-hcv-infection-a-systematic-review-and-meta-analysis
#1
Haotian Liao, Ping Tan, Zexin Zhu, Xiaokai Yan, Jiwei Huang
BACKGROUND: Studies focusing on the efficacy of SOF+DCV regimen on liver transplantation recipients with HCV infection are still limited. In the current study, we aimed to perform a systematic review and meta-analysis to evaluate the efficacy and tolerability of SOF+DCV regimen, with or without ribavirin, on post-LT setting. METHODS: A systematic literature search of various databases as well as abstracts of major liver diseases conferences was performed. Studies with SVR data in HCV infected liver transplantation recipients treated with daclatasvir/sofosbuvir regimen were included...
January 9, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28089176/inflammatory-myofibroblastic-tumor-an-unusual-hepatic-tumor-mimicking-liver-abscess
#2
Yan-Wen Jin, Fu-Yu Li, Nan-Sheng Cheng
No abstract text is available yet for this article.
January 6, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28065745/alteration-of-methyl-cpg-binding-domain-family-in-patients-with-chronic-hepatitis-b
#3
Jing Zhao, Yu-Chen Fan, Long-Yan Chen, Shuai Gao, Feng Li, Kai Wang
BACKGROUND AND OBJECTIVE: Epigenetics contributes to the outcome of chronic hepatitis B virus (HBV) infection. However, the role of methyl-CpG binding domain (MBD) family in the natural history of chronic hepatitis B (CHB) has not been demonstrated. It is aimed to investigate the dynamic expression of MBD family and assess the potential association of MBD family in the progression of CHB. METHODS: Quantitative real-time polymerase chain reaction (RT-PCR) was used to determine the mRNA levels of MBD family in peripheral blood mononuclear cells (PBMCs) from 223 patients with CHB as training cohort, 146 patients with CHB as validation cohort [immune-tolerant (IT), immune clearance (IC), non/low-replicative (LR) and HBeAg negative hepatitis (ENH)], and 14 healthy controls (HCs)...
January 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28065744/efficacy-and-safety-of-glucagon-like-peptide-1-receptor-agonists-in-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#4
Yajie Dong, Qingguo Lv, Sheyu Li, Yuan Wu, Ling Li, Juan Li, Fang Zhang, Xin Sun, Nanwei Tong
BACKGROUND AND OBJECTIVE: New drugs are urgently needed for the treatment of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). The aim of this meta-analysis was to evaluate the efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in NAFLD/NASH. METHODS: We searched the MEDLINE, Embase, and Cochrane Library Central to identify randomized controlled trials (RCTs) and observational studies that compared GLP-1RAs with a control treatment or baseline values with respect to efficacy and safety in patients with NAFLD/NASH...
January 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28065743/high-expression-of-trim11-correlates-with-poor-prognosis-in-patients-with-hepatocellular-carcinoma
#5
Yue Chen, Liang Li, Xiaoxing Qian, Yongsheng Ge, Geliang Xu
BACKGROUND: Tripartite Motif Containing 11 (TRIM11), a member of TRIM proteins is overexpressed in gliomas and lung cancer. However, the role of TRIM11 in hepatocellular carcinoma (HCC) is unknown. BASIC PROCEDURES: Herein, we aimed to investigate the expression and clinical significance role of TRIM11 in HCC. MAIN FINDING: In this study, our data showed significant higher TRIM11 in HCC tissues (n=117) than in the matched non-tumor liver (NTL) tissues (P<0...
January 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28043790/thymidylate-synthase-gene-polymorphisms-as-important-contributors-affecting-hepatocellular-carcinoma-prognosis
#6
X Wang, X Sun, X Du, F Zhou, F Yang, J Xing, G Dong, X Guo
BACKGROUND: Thymidylate synthase (TYMS), a key rate-limiting enzyme in the folate metabolism, plays essential roles in the development of several malignancies including hepatocellular carcinoma (HCC). Nonetheless, the association of the single nucleotide polymorphisms (SNPs) in TYMS gene with the prognosis of Chinese HCC patients remains unknown. METHODS: A total of 492 HCC patients who underwent surgery treatment were included in this study. Five functional SNPs (rs2847153, rs2853533, rs502396, rs523230, and rs9967368) in TYMS gene were genotyped using the iPLEX genotyping system...
December 30, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28043789/intrahepatic-upregulation-of-mrtf-a-signaling-contributes-to-increased-hepatic-vascular-resistance-in-cirrhotic-rats-with-portal-hypertension
#7
Lei Zheng, Jun Qin, Longci Sun, Liang Gui, Chihao Zhang, Yijun Huang, Wensheng Deng, An Huang, Dong Sun, Meng Luo
BACKGROUND: Portal hypertension in cirrhosis is mediated, in part, by increased intrahepatic resistance, reflecting massive structural changes associated with fibrosis and intrahepatic vasoconstriction. Activation of the Rho/MRTF/SRF signaling pathway is essential for the cellular regulatory network of fibrogenesis. The aim of this study was to investigate MRTF-A-mediated regulation of intrahepatic fibrogenesis in cirrhotic rats. METHODS: Portal hypertension was induced in rats via an injection of CCl4 oil...
December 30, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28041935/role-of-interleukin-23-in-monocyte-derived-dendritic-cells-of-hbv-related-acute-on-chronic-liver-failure-and-its-correlation-with-the-severity-of-liver-damage
#8
Suxia Bao, Jianming Zheng, Ning Li, Chong Huang, Mingquan Chen, Qi Cheng, Qian Li, Qing Lu, Mengqi Zhu, Qingxia Ling, Kangkang Yu, Shengshen Chen, Guangfeng Shi
BACKGROUND: The role of interleukin-23 (IL-23) in monocyte-derived dendritic cells (MoDCs) from hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) patients remains unclear. The aim of this study was to observe the correlation between the activation of the IL-23 signaling pathway and the prognosis of HBV-ACLF patients. MATERIALS AND METHODS: The baseline levels of serum IL-6, IL-12, IL-17, IL-23, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) from immune tolerant (IT), chronic hepatitis B (CHB), HBV-ACLF patients and healthy individuals who served as healthy controls (HCs) were analyzed using the Luminex system, whereas serum IL-23 from HBV-ACLF patients was measured by ELISA before and after treatment...
December 29, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27989689/cd40-signaling-and-hepatic-steatosis-unanticipated-links
#9
Sébastien Lepreux, Julien Villeneuve, Antoine Dewitte, Annie M Bérard, Alexis Desmoulière, Jean Ripoche
Obesity predisposes to an increased risk of nonalcoholic fatty liver disease (NAFLD). Hepatic steatosis is the key pathological feature of NAFLD and has emerged as a metabolic disorder in which innate and adaptive arms of the immune response play a central role in disease pathogenesis. Recent studies have revealed unexpected relationships between CD40 signaling and hepatic steatosis in high fat diet rodent models. CD154, the ligand of CD40, is a mediator of inflammation and controls several critical events of innate and adaptive immune responses...
December 15, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27988305/mutations-in-basal-core-promoter-is-associated-with-significant-fibrosis-in-both-hbeag-positive-and-negative-treatment-na%C3%A3-ve-chronic-hepatitis-b
#10
Li-Bo Yan, Xia Zhu, Lang Bai, Xiao-Qiong Tang, Ling-Yao Du, En-Qiang Chen, Ling-Bo Liang, Hong Tang
AIM: Assessment of liver fibrosis is important for the decision of whether to administrate antiviral treatment in chronic Hepatitis B (CHB) patients. The objective was to investigate the relationship between clinical factors and fibrosis, identify predictors of significant fibrosis in Chinese CHB patients. METHODS: Two hundred and seventy-four treatment-naïve CHB patients (208 HBeAg-positive and 66 HBeAg-negative) who performed transient elastography were consecutively included...
December 14, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27956256/circulating-micrornas-possible-role-as-non-invasive-diagnostic-biomarkers-in-liver-disease
#11
Kishor Pant, Senthil K Venugopal
Liver is the central organ for metabolism and the hepatocytes metabolize several drugs, hepatotoxins, alcohol, etc. Continuous exposure of the hepatocytes to these toxins result in various chronic diseases, such as alcoholic liver disease, non-alcoholic fatty liver disease, viral hepatitis and hepatocellular carcinoma. Although several diagnostic methods, such as serum markers, liver biopsy or imaging studies are currently available, most of these are either invasive or detect the disease at advanced stages...
December 9, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27956255/tumor-associated-autoantibodies-against-fascin-as-a-novel-diagnostic-biomarker-for-esophageal-squamous-cell-carcinoma
#12
Wen-Xia Chen, Xin-Bin Hong, Chao-Qun Hong, Ming Liu, Lan Li, Li-Sheng Huang, Li-Yan Xu, Yi-Wei Xu, Yu-Hui Peng, En-Min Li
BACKGROUND AND OBJECTIVE: Autoantibodies against tumor-associated antigens (TAAs) have been found in many kinds of cancers, and might serve as biomarkers for early cancer diagnosis. The present study was carried out to test if there is any relation between autoantibodies against Fascin and esophageal squamous cell carcinoma (ESCC). METHODS: One hundred and forty-nine patients with ESCC and 98 control subjects were recruited in the study. The levels of circulating autoantibodies against Fascin were measured by enzyme-linked immunosorbent assay (ELISA)...
December 9, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27939910/identification-of-micrornas-as-biomarkers-for-cholangiocarcinoma-detection-a-diagnostic-meta-analysis
#13
J Zhou, Z Liu, S Yang, X Li
BACKGROUND: Cholangiocarcinoma (CCA) is a common biliary malignancy that results in high mortality and poor survival rates. The diagnostic capacity of miRNAs in CCA detection is still controversial. Current meta-analysis evaluate the evidence on the capacity of miRNAs for CCA diagnosis. METHODS: A systematic literature search for relevant articles in PubMed, Embase and Web of science database up to 10 April 2016 was conducted. The pooled sensitivity, specificity, positive and negative likelihood ratios (PLR and NLR, respectively), diagnostic odds ratio (DOR) and area under the curve (AUC) were pooled to assess the overall diagnostic value of miRNA...
December 8, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27939909/liver-failure-after-long-limb-gastric-bypass
#14
Mike Ralki, David Cassiman, Jurgen Van Dongen, Michel Ferrante, Lode Van Overbeke
Liver failure is reported with increasing frequency in patients who underwent bariatric surgery for morbid obesity. In most cases, liver transplantation is the only possible treatment to avoid fatal outcome. Although most cases are observed after older bariatric surgery techniques characterized by high malabsorption rates, we report on a 38-year-old woman who developed liver failure seven months after long-limb gastric bypass.
December 8, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27964840/induced-pluripotent-stem-cells-an-unlimited-source-of-organs-for-transplantation
#15
J De Vos, S Assou
Organ production outside the human body could address the shortage of organs for transplantation. However, in vitro organ production is still a faraway perspective, particularly because of the difficulty in establishing an effective vascularization. A new emerging technology proposes to use carrier animals for the development of human organs. In this approach, induced pluripotent stem cells (iPSC) are injected in animal embryos to produce chimeric animals that contain autologous human organs.
December 7, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27939097/primary-hepatic-pregnancy
#16
Tao Wang, PingYang Chen, DuJun Bian
No abstract text is available yet for this article.
December 6, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27939096/focal-adhesion-kinase-a-promising-therapeutic-target-in-pancreatic-adenocarcinoma
#17
Emilie Decaup, Julia Rochotte, Stéphane Pyronnet, Corinne Bousquet, Christine Jean
Pancreatic ductal adenocarcinoma (PDAC) remains a deadly cancer, characterized by a uniquely immunosuppressive and fibrotic microenvironment responsible for its high chemoresistance. Jiang et al. identify FAK (focal adhesion kinase) activity as an interesting therapeutic target, the inhibition of which drastically reduces PDAC microenvironment deleterious features. In combination with gemcitabine and immune-checkpoint therapy, FAK inhibitor promotes long-term tumor stasis with extended survival in PDAC mouse models...
December 6, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27894906/relationship-between-nr1i2-polymorphisms-and-inflammatory-bowel-disease-risk-a-systematic-review-and-meta-analysis
#18
Man-Yi Sun, Jing-Na Lin
BACKGROUND AND OBJECTIVE: Inconsistent results regarding an association between polymorphisms within the Homo sapiens nuclear receptor subfamily 1 group I member 2 (NR1I2) gene and susceptibility to inflammatory bowel disease (IBD) have been reported. A systematic review and meta-analysis was thus undertaken to determine whether NR1I2 gene polymorphisms are associated with an increased risk of IBD. METHODS: Article retrieval was performed using on-line databases, such as PubMed, Embase, CENTRAL, and WOS...
November 25, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27863926/combination-of-temsirolimus-and-adriamycin-exhibits-an-enhanced-antitumor-effect-in-hepatocellular-carcinoma
#19
Hong-Gang Kang, Bao-Zhong Wang, Jing Zhang, Mei-Rong Liu, Ying-Xue Li
OBJECTIVE: The oncogenic PI3K/Akt/mTOR pathway is frequently activated in hepatocellular carcinoma (HCC). The aim of this study is to investigate the anti-HCC effect of combination of temsirolimus, an mTOR inhibitor, and adriamycin, a routinely used drug for treating HCC. METHODS AND MATERIALS: Proliferation of HCC cells exposure to temsirolimus, adriamycin, and their combination was determined using MTT assay in vitro as well as in a nude mice model in vivo. Cell apoptosis was examined using flow cytometry...
November 15, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27863925/number-and-function-of-circulating-endothelial-progenitor-cells-in-patients-with-primary-budd-chiari-syndrome
#20
Rui Huang, Qingqiao Zhang, Qianxin Huang, Maoheng Zu, Hao Xu, Lingyu Zeng
BACKGROUND AND AIM: Primary Budd-Chiari syndrome (BCS) is associated with vascular endothelial injury. Circulating endothelial progenitor cells (EPCs) provide an endogenous mechanism to repair endothelial injury. This study investigated the levels and functionality of EPCs in patients with primary BCS. METHODS: EPCs (CD34(+)/CD133(+)/KDR(+)) were quantified in 82 patients with primary BCS (inferior vena cava type: n=19; hepatic vein type: n=22; and mixed type: n=41), 10 cirrhosis controls (CC group) and 10 age-matched healthy controls (HC group), using flow cytometry...
November 15, 2016: Clinics and Research in Hepatology and Gastroenterology
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