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Clinics and Research in Hepatology and Gastroenterology

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https://www.readbyqxmd.com/read/28526245/lymphogenous-metastasis-to-the-transverse-colon-that-originated-from-signet-ring-cell-gastric-cancer-a-case-report-and-review-of-the-literature
#1
Hirofumi Sonoda, Kazushige Kawai, Hironori Yamaguchi, Koji Murono, Manabu Kaneko, Takeshi Nishikawa, Kensuke Otani, Kazuhito Sasaki, Koji Yasuda, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Hiroaki Nozawa, Soichiro Ishihara, Susumu Aikou, Hiroharu Yamashita, Tetsuo Ushiku, Yasuyuki Seto, Masashi Fukayama, Toshiaki Watanabe
Metastases to the colon are rare and a high-frequency primary region is the stomach. In cases of metastases to the colon, the morphological type of the metastatic region is mostly the infiltrating type of poorly differentiated or undifferentiated adenocarcinoma with lymph and blood vessel invasion. A case of cancer metastasis to the transverse colon that originated from advanced gastric cancer, which shows the difficulties in the precise diagnosis of metastases to the colon, is presented. In the present case, the gastric carcinoma was determined to be an advanced infiltrative ulcerative adenocarcinoma and the colon carcinoma was determined to be a superficial depressed adenocarcinoma...
May 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28526244/spontaneous-clearance-of-chronic-hepatitis-c-virus-infection-in-hiv-positive-patients-southeastern-france
#2
LETTER
Maxime Algoud, Hervé Tissot-Dupont, Amélie Menard, Danielle Botta-Fridlund, Sarah Aherfi, Philippe Colson
No abstract text is available yet for this article.
May 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28506454/esophageal-intramural-pseudodiverticulosis-a-rare-cause-of-stenosis
#3
Leila Abbes, Guillaume Perrod, Gabriel Rahmi, Christophe Cellier
No abstract text is available yet for this article.
May 11, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28502590/spontaneous-bacterial-peritonitis-due-to-listeria-monocytogenes-always-to-be-remembered
#4
R Gaspar, S Rodrigues, G Macedo
No abstract text is available yet for this article.
May 11, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28502591/cd8-cd28-cd8-cd28-t-cell-equilibrium-can-predict-the-active-stage-for-patients-with-inflammatory-bowel-disease
#5
Shi-Xue Dai, Hong-Xiang Gu, Qian-Yi Lin, Shao-Zhuo Huang, Tiao-Si Xing, Qing-Fang Zhang, Gang Wu, Min-Hua Chen, Wan-Er Tan, Hong-Jian Jian, Zhong-Wen Zheng, Tao Zhong, Min-Hai Zhang, Xing-Fang Cheng, Peng Huang, Guang-Jie Liao, Wei-Hong Sha
BACKGROUND/AIM: The balance of blood CD8(+)CD28(+)/CD8(+)CD28(-) T cells has been verified to be vital for patients with ulcerative colitis (UC), but their role in inflammatory bowel disease (IBD) remains unknown. This investigation aimed to evaluate the efficiency of the balance in predicting the active stage in IBD patients. METHODS: Fifty-three IBD subjects, including 31 UC and 22 Crohn's disease (CD) patients, were enrolled, and their peripheral blood CD8(+)CD28(+) and CD8(+)CD28(-) T cell levels were tested using flow cytometry...
May 10, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28499985/functional-mir-146a-mir-149-mir-196a2-and-mir-499-polymorphisms-and-the-susceptibility-to-hepatocellular-carcinoma-an-updated-meta-analysis
#6
Lei Zheng, Chunbo Zhuang, Junwei Zhao, Liang Ming
OBJECTIVE: Single nucleotide polymorphisms of miRNAs play important roles in the pathogenesis of hepatocellular carcinoma (HCC). To evaluate the association between four common miRNAs (miR-146a rs2910164; miR-149 rs2292832; miR-196a2 rs11614913 and miR-499 rs3746444) and HCC risk, an updated meta-analysis was performed. METHODS: 32 studies including 12,405 HCC cases and 15,056 controls were used for this meta-analysis. There were 22 studies with 7894 cases and 10,221 controls for miR-146a, 9 studies with 2684 HCC cases and 3464 controls for miR-149, 17 studies with 6937 cases and 8217 controls for miR-196a2 and 16 studies with 4158 cases and 5264 controls for miR-499...
May 9, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28483307/management-of-rectal-squamous-cell-carcinoma
#7
LETTER
Jean-Baptiste Delhorme, Waisse Waissi, Benoit Romain, Catherine Schumacher, Kelle C Freel, Patrick Dufour, Cécile Brigand, Serge Rohr
No abstract text is available yet for this article.
May 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28438572/co-administration-of-tenofovir-plus-protease-inhibitor-based-antiretroviral-therapy-during-sofosbuvir-ledipasvir-treatment-for-hcv-infection-much-ado-about-nothing
#8
LETTER
Lucia Taramasso, Elena Ricci, Benedetto Maurizio Celesia, Paolo Bonfanti, Tiziana Quirino, Nicola Squillace, Laura Ambra Nicolini, Paolo Maggi, Canio Martinelli, Giuseppe Vittorio De Socio, Antonio Di Biagio
No abstract text is available yet for this article.
April 21, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28438571/effect-of-intestinal-epithelial-autophagy-on-bacterial-translocation-in-severe-acute-pancreatitis
#9
Weiwei Wen, Hongmei Zheng, Yingjian Jiang, Luqiao Huang, Dehui Li, Jian Zhang, Dianliang Zhang
BACKGROUND AND OBJECTIVE: We examined the impact of autophagy activation on bacterial translocation (BT) and tight junction (TJ) proteins in the intestinal mucosa of patients with severe acute pancreatitis (SAP). METHODS: Thirty-one SAP patients were divided into two groups, BT(+) and BT(-), according to the presence of BT in the blood, as detected by 16S rDNA sequencing. Eight healthy individuals were included in the control group. Serum endotoxin levels were measured by ELISA...
April 21, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28438570/analysis-of-intrahepatic-total-hbv-dna-cccdna-and-serum-hbsag-level-in-chronic-hepatitis-b-patients-with-undetectable-serum-hbv-dna-during-oral-antiviral-therapy
#10
Jie Li, Xizhen Sun, Jianting Fang, Chuanxi Wang, Guoqing Han, Wanhua Ren
BACKGROUND: This study aimed to investigate the relationship between intrahepatic cccDNA and serum HBsAg in chronic Hepatitis B (CHB) patients with undetectable serum HBV DNA during antiviral therapy. METHODS: We investigated HBsAg serum levels and their relationship to intrahepatic total cccDNA and HBV DNA in CHB patients with undetectable serum HBV DNA during oral antiviral therapy. Intrahepatic cccDNA and HBV DNA quantitation were performed in the same needle biopsy material, while serum HBsAg, HBeAg and HBV DNA levels were measured in samples drawn on the day of the liver biopsy...
April 21, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28438569/methylprednisolone-liver-toxicity-a-new-case-and-a-french-regional-pharmacovigilance-survey
#11
Jérôme Dumortier, Judith Cottin, Caroline Lavie, Olivier Guillaud, Valérie Hervieu, Christine Chambon-Augoyard, Jean-Yves Scoazec, Sandra Vukusic, Thierry Vial
Reported hepatotoxicity induced by corticosteroids is very rare, and the diagnosis is highly challenging in the context of auto-immune disease. We report here a case of high-dose methylprednisolone (MP)-induced acute hepatitis confirmed by liver histology in a patient with multiple sclerosis (MS) and a case series (n=4) notified to the French Pharmacovigilance center of Lyon. In all 5 cases, other common causes of hepatitis were excluded. The causal relationship with MP pulse therapy was supported by the fact that MP was the only culprit drug...
April 21, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28416360/primary-hepatic-angiosarcoma-and-liver-transplantation-radiological-surgical-histological-findings-and-clinical-outcome
#12
M Tran Minh, A Mazzola, F Perdigao, F Charlotte, G Rousseau, F Conti
Angiosarcoma is a rare type of soft tissue sarcoma that accounts for less than 1% of all sarcomas and only 2% of all primary hepatic tumours. Thorotrast, arsenic, and vinyl chloride monomer are frequently listed as occupational exposure risks. The estimated latency is long (10-40 years) in occupational cases and very long (60 years or more) in non-occupational cases. The symptoms and CT-scan appearance of hepatic angiosarcoma (HAS) are non-specific. We present a case of a 65-year-old Caucasian male with history of cryptogenic cirrhosis, low alpha-foetoprotein levels and a single, 4-cm nodule of potential atypical hepatocellular carcinoma (no washout at MRI and CT-scan) in segment VIII...
April 14, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28416359/marital-status-is-an-independent-prognostic-factor-for-pancreatic-neuroendocrine-tumors-patients-an-analysis-of-the-surveillance-epidemiology-and-end-results-seer-database
#13
Huaqiang Zhou, Yuanzhe Zhang, Yiyan Song, Wulin Tan, Zeting Qiu, Si Li, Qinchang Chen, Shaowei Gao
BACKGROUND AND OBJECTIVES: Marital status's prognostic impact on pancreatic neuroendocrine tumors (PNET) has not been rigorously studied. We aimed to explore the relationship between marital status and outcomes of PNET. METHODS: We retrospectively investigated 2060 PNET cases between 2004 and 2010 from Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by Chi(2) test, t-test as appropriate. Kaplan-Meier methods and COX proportional hazard models were used to ascertain independent prognostic factors...
April 14, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28412192/association-analysis-of-rac1-single-nucleotide-polymorphisms-with-ulcerative-colitis
#14
LETTER
Mohammad Taher, Nasser Ebrahimi Daryani, Mona Hedayat, Mohammad Eslamian, Elham Farhadi, Mahdi Mahmoudi, Samira Shirzad, Mohammd Kazem Nouri Taromlou, Meghedi Chaharmahali, Mohammad Hossein Nicknam, Mohammad Bashashati, Nima Rezaei
No abstract text is available yet for this article.
April 12, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28412191/red-cell-distribution-width-rdw-is-associated-with-cardiovascular-disease-risk-in-crohn-s-disease
#15
LETTER
Haider Al Taii, Zaid Yaqoob, Sadeer G Al-Kindi
No abstract text is available yet for this article.
April 12, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28412190/exogenous-growth-factor-based-regenerative-therapy-in-alcoholic-cirrhosis-patients-renders-limited-effect-on-hemostatic-elements
#16
LETTER
Priyanka Saxena, Chhagan Bihari, Roshni Mirza, Ajeet Singh Bhadoria, Lovkesh Anand, Shiv K Sarin
No abstract text is available yet for this article.
April 12, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28373016/transpapillary-passage-of-a-giant-bile-duct-stone-after-endoscopic-papillary-large-balloon-dilation-and-short-term-stenting
#17
Vincent Zimmer
No abstract text is available yet for this article.
March 31, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28365139/crohn-s-colitis-development-of-a-multiplex-gene-expression-assay-comparing-mrna-levels-of-susceptibility-genes
#18
Edda Russo, Letizia Lombardelli, Francesco Giudici, Tiziana Cavalli, Ferdinando Ficari, Marilena Fazi, Stefano Scaringi, Livia Biancone, Federica Logiodice, Mariateresa Nesi, Anna Latiano, Vito Annese, Maria Gabriella Torcia, Paolo Bechi, Francesco Tonelli, Marie-Pierre Piccinni, Cecilia Malentacchi
Crohn's disease (CD) is a multifactorial immunologically mediated disease. In this study we explored, for the first time, the efficacy of the Multiplex Gene Assay technology for detecting mRNA expression profile of 24 selected CD related genes in endoscopic biopsies and surgical specimens from CD patients with colonic localization of the disease. The polymorphisms of genes most frequently associated with CD were also analysed in DNA samples from the same patients. The analysis of endoscopic samples showed increased expression of 7 genes in inflamed mucosa compared to non-inflamed mucosa and suggests the activation of the autophagy process and of a Th17 adaptive response...
March 29, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28363424/higher-pkd3-expression-in-hepatocellular-carcinoma-hcc-tissues-predicts-poorer-prognosis-for-hcc-patients
#19
Haiyun Yang, Ming Xu, Xiufang Chi, Qun Yan, Yadong Wang, Wen Xu, Kangmin Zhuang, Aimin Li, Side Liu
AIM: Protein kinase D (PKD) acts as a key mediator in several cancer development signaling pathways. The aim of this study was to investigate the clinical significance and prognostic value of PKD3 expression in hepatocellular carcinoma (HCC) patients after hepatectomy. METHODS: PKD3 mRNA and protein expression levels in tumor and matched non-tumoral (NT) tissues, HCC cell lines were evaluated by quantitative PCR (qRT-PCR), western blotting and immunohistochemical staining (IHC)...
March 28, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28359636/hepatic-perivascular-epithelioid-tumor-pecoma-a-case-report
#20
Hélder Cardoso, Marco Silva, Filipe Vilas-Boas, Rui Cunha, Joanne Lopes, José Costa Maia, Guilherme Macedo
A 37-year-old female had liver nodules found in an abdominal ultrasound scan. The radiological features were suggestive of hepatocellular adenomas, although there were some atypical findings. Two years later, one of the nodules showed dimensional progression and intralesional hemorrhage. The patient underwent a left hepatectomy and the postoperative course was uneventful. The histological exam and the immunohistochemistry were consistent with the diagnosis of PEComa. The PEComa is a mesenchymal tumor rarely described in the liver...
March 27, 2017: Clinics and Research in Hepatology and Gastroenterology
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