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Clinics and Research in Hepatology and Gastroenterology

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https://www.readbyqxmd.com/read/29150356/cryptococcosis-manifesting-as-isolated-biliary-infection-case-report-and-brief-review-of-literature
#1
Hua-Ying Zhou, Xiao-Bo Zeng, Sheng-Long Shi, Min Wang, Da-Min Li
BACKGROUND: Biliary cryptococci infection is rare, which is frequently diagnosed by exploratory laparotomy, preoperative diagnosis is difficult. CASE PRESENTATION: A 14-year-old girl presented with intermittent jaundice for 6 years. She had no pruritus, anorexia, nausea or vomiting, fever, abdominal pain, or clay stools. Laboratory tests showed obstructive jaundice, eosinophilia, and increased IgE levels. The patient was ultimately diagnosed as Cryptococcal infection by bone marrow culture...
November 14, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29102545/association-of-nlrp3-single-nucleotide-polymorphisms-with-ulcerative-colitis-a-case-control-study
#2
S Hanaei, M Sadr, A Rezaei, S Shahkarami, N Ebrahimi Daryani, A Z Bidoki, N Rezaei
BACKGROUND: Ulcerative colitis (UC) is inflammatory bowel disease (IBD), characterized by chronic inflammation episodes within mucosal layer of the intestine mostly affecting colon and rectum. As the role of innate immunity in pathogenesis of disease and important role of NLRP3, the aim of this study is to investigate the association of NLRP3 SNPs with UC in Iranian patients. METHODS: Blood samples from 45 UC patients and 56 healthy subjects were tested for single nucleotide polymorphisms in rs10754558, rs3806265, rs4612666, and rs35829419 of NLRP3 gene, using real-time PCR method...
November 1, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29102544/gut-microbiota-and-hypertension-from-pathogenesis-to-new-therapeutic-strategies
#3
Yongbo Kang, Yue Cai
Hypertension (HTN) has become a global public health concern and a major risk factor for cardiovascular, cerebrovascular, and kidney diseases. The complex interplay of genetic and environmental influences is important for the development of the disease. Accumulating evidence has illustrated the association of dysbiosis of gut microbiota with hypertension. Certain gut microbial strains may play either a pathogenic or a protective role in the development of hypertension. Oral probiotics can therefore represent a therapeutic approach for hypertension treatment...
November 1, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29102418/the-utility-of-food-antigen-test-in-the-diagnosis-of-crohn-s-disease-and-remission-maintenance-after-exclusive-enteral-nutrition
#4
Gefei Wang, Jianan Ren, Guanwei Li, Qiongyuan Hu, Guosheng Gu, Huajian Ren, Zhiwu Hong, Jieshou Li
BACKGROUND: Crohn's disease (CD) involves intensive immunologic responses to food antigens. Exclusive enteral nutrition (EEN) showed efficacy in inducing disease remission. However, relapse commonly occurred when normal diet was reintroduced. We aimed to investigate the food-specific IgG antibodies of CD, and clarify the effects of exclusion diet guided by food-specific antibodies on remission maintenance after EEN. METHODS: All available data of food-specific antibodies were retrieved from the database and analyzed for the diagnostic value...
October 25, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29066092/longitudinal-monitoring-of-liver-stiffness-by-acoustic-radiation-force-impulse-imaging-in-patients-with-chronic-hepatitis%C3%A2-b-receiving-entecavir
#5
Sheng-Di Wu, Hong Ding, Li-Li Liu, Yuan Zhuang, Yun Liu, Li-Sha Cheng, Si-Qi Wang, Yu-Jen Tseng, Ji-Yao Wang, Wei Jiang
BACKGROUND: Acoustic radiation force impulse (ARFI) imaging measures liver stiffness (LS), which significantly correlates with the stage of liver fibrosis in treatment-naive patients with chronic hepatitis B (CHB). AIM: We aimed to prospectively assess the clinical usefulness of ARFI during long-term antiviral therapy in CHB. METHOD: Seventy-one CHB patients were consecutively recruited and paired liver biopsies were performed in 27 patients...
October 21, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29031875/soluble-epoxide-hydrolase-inhibition-with-t-tucb-alleviates-liver-fibrosis-and-portal-pressure-in-carbon-tetrachloride-induced-cirrhosis-in-rats
#6
Chi-Hao Zhang, Lei Zheng, Liang Gui, Jia-Yun Lin, Yi-Ming Zhu, Wen-Sheng Deng, Meng Luo
BACKGROUND/AIMS: Fibrosis and increased intrahepatic vascular resistance are the hallmarks of chronic inflammatory disorders of the liver and cirrhosis. Inhibitors of the enzyme soluble epoxide hydrolase reduce fibrosis in several disease models. The present study aimed at investigating the effects of soluble epoxyhydrolase inhibition with t-TUCB in tetrachloride-induced cirrhosis in rats. METHODS: The models were established by CCl4 (2ml/kg) given subcutaneously for 14 weeks...
October 11, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29031874/an-update-on-the-physiopathology-and-therapeutic-management-of-cholestatic-pruritus-in-children
#7
A Thébaut, D Debray, E Gonzales
Pruritus is a disabling symptom accompanying chronic cholestasis. In extreme cases, the refractory nature of pruritus can result in a need for invasive therapies including liver transplantation. The pathogenesis of pruritus in cholestatic disease is poorly understood. It may involve a specific neural pathway (similar to that associated with pain) regulated by several pruritogenic substances such as bile acids, opioids, serotonin, and the more recently identified lysophosphatidic acid. While the therapeutic management of cholestatic pruritus is well established in adults, there is no consensus in children, in light of the difficulty of conducting controlled clinical studies...
October 11, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28986125/biliary-stenosis-after-transjugular-intrahepatic-portosystemic-shunt
#8
LETTER
Jérôme Dumortier, Mathieu Pioche, Arnaud Muller, Thierry Ponchon, Luc Henry, Pierre-Jean Valette, Liadeh Cuminal
No abstract text is available yet for this article.
October 3, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28943235/paraampullary-gangliocytic-paraganglioma
#9
Elise Colle, Ilyass Zouhry, Nikias Colignon, Najat Mourra
No abstract text is available yet for this article.
September 21, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28927658/nucleotide-and-amino-acid-diversity-of-hepatitis%C3%A2-b-virus-surface-antigen-in-acute-infections-southeastern-france
#10
LETTER
Paul Rémi Petit, Patrick Borentain, Sarah Aherfi, Alban Benezech, Danielle Botta-Fridlund, Catherine Tamalet, Anne Motte, René Gerolami, Philippe Colson
No abstract text is available yet for this article.
September 15, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28927657/endoscopic-training-a-nationwide-survey-of-french-fellows-in-gastroenterology
#11
Aurélien Amiot, Guillaume Conroy, Yann Le Baleur, Jérôme Winkler, Maxime Palazzo, Xavier Treton
BACKGROUND: During their 4 years of training, French fellows in gastroenterology should acquire theoretical and practical competency in gastrointestinal (GI) endoscopy. AIMS: To evaluate the delivery of endoscopy training to French GI fellows and perception of learning. METHODS: A nationwide electronic survey was carried out of French GI fellows using an anonymous, 17-item electronic questionnaire. RESULTS: A total of 291 out of 484 (60%) GI fellows responded to the survey...
September 15, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28927656/features-and-outcomes-from-a-retrospective-study-of-570%C3%A2-hospitalized-chinese-patients-with-drug-induced-liver-injury
#12
Lili Pang, Wanna Yang, Fengqin Hou
AIMS: To investigate the clinical features and outcomes of hospitalized patients with drug-induced liver injury (DILI). METHODS: The medical records of hospitalized patients with DILI from January 1997 through July 2016 were reviewed. RESULTS: Five hundred seventy cases were reviewed, of which 381 (66.8%) were female. Four hundred fifty-eight cases (80.4%) presented with hepatocellular injury, 53 (9.3%) with cholestatic injury and 59 (10...
September 15, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28882739/autoimmune-hepatitis%C3%A2-%C3%A2-update-on-clinical-management-in-2017
#13
REVIEW
Timur Liwinski, Christoph Schramm
Autoimmune hepatitis (AIH) is a progressive immune mediated liver disease of unknown origin. Key diagnostic features include hypergammaglobulinemia/elevated serum-IgG, characteristic circulating autoantibodies, periportal hepatitis with interface activity on liver biopsy and the exclusion of hepatotropic viruses. However, the diagnosis is challenging in cholestatic and severe presentations. It can be difficult to differentiate AIH from drug-induced liver injury. Although many patients initially respond to standard immunosuppressive therapy, a significant proportion experiences intolerable side effects or insufficient treatment response...
September 4, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28870440/the-noninvasive-diagnosis-of-esophageal-varices-and-its-application-in-clinical-practice
#14
REVIEW
Etienne Pateu, Frédéric Oberti, Paul Calès
Here, we review recent improvements made to different noninvasive tests used for the diagnosis of esophageal varices (EV) in the light of the recent Baveno VI recommendation and with an emphasis on clinical application. Like for fibrosis tests, these noninvasive EV tests can be classified as direct markers when they provide a visualization of EV (including all imaging procedures like endoscopy or radiology) and as indirect markers when they do not (blood markers or elastometry). Clinical descriptors expressed as percentages, especially the spared endoscopy rate and the missed high-risk esophageal varices (HREV) rate, are more eloquent in this setting than classical statistical descriptors like accuracy...
September 1, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28867077/characteristics-of-patients-with-hepatitis-b-virus-and-hepatitis-c-virus-dual-infection-in-a-western-european-country-comparison-with-monoinfected-patients
#15
Astrid Marot, Aïmen Belaid, Hans Orlent, Thomas Sersté, Peter Michielsen, Isabelle Colle, Wim Laleman, Chantal de Galocsy, Hendrik Reynaert, François D'Heygere, Christophe Moreno, Christopher Doerig, Jean Henrion, Pierre Deltenre
The epidemiology of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections is continuously evolving. Updated data on dual HBV and HCV infection are still needed. AIMS: To assess the main characteristics of patients with HBV and HCV dual infection, to compare these with those of patients infected with either HBV or HCV and, among patients with dual infection, to assess fibrosis according to HCV replication. METHODS: Data of 23 patients with dual infection were compared to data from 92 age and sex-matched HBV or HCV monoinfected patients...
August 31, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28866090/is-within-normal-range-liver-enzymes-associated-with-metabolic-syndrome-in-adults
#16
Leila Nikniaz, Zeinab Nikniaz, Jafar Sadegh Tabrizi, Homayoun Sadeghi-Bazargani, Mostafa Farahbakhsh
BACKGROUND: Considering the clear association between metabolic syndrome and future cardiovascular disease, early detection of metabolic syndrome is important. This study was conducted to assess the correlation between metabolic syndrome components and within-normal-range of liver enzymes in Iranian adults. METHODS: This cross-sectional study was comprised of 700 Iranian adults in the districts of East Azerbaijan-Iran in 2015. The levels of lipid profile and glucose were measured by enzymatic colorimetric methods...
August 30, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28991536/acute-ischemic-gastric-ulcer
#17
LETTER
Luca Roncati, Antonio Manenti, Emilio Simonini, Alberto Farinetti
No abstract text is available yet for this article.
October 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28935504/isolated-hepatic-tuberculosis-in-the-caudate-lobe-mimicking-intrahepatic-carcinoma
#18
Huanye Liu, Jiqiao Zhu, Hongmeng Dong, Ying Wang, Jun Ma, Jiantao Kou, Xianliang Li, Qiang He
Although tuberculosis (TB) remains a worldwide epidemic, isolated hepatic TB is an extremely rare entity and poorly described in the literature. Isolated hepatic TB may pose a diagnostic dilemma due to the non-specific clinical symptoms and imaging features. We present a case of a 54-year-old female with an isolated caseating granulomatous lesion at the caudate lobe of liver involving the pancreatic head.
October 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28918932/building-and-verifying-a-severity-prediction-model-of-acute-pancreatitis-ap-based-on-bisap-mews-and-routine-test-indexes
#19
Jiang-Feng Ye, Yu-Xin Zhao, Jian Ju, Wei Wang
PURPOSE: To discuss the value of the Bedside Index for Severity in Acute Pancreatitis (BISAP), Modified Early Warning Score (MEWS), serum Ca2+, similarly hereinafter, and red cell distribution width (RDW) for predicting the severity grade of acute pancreatitis and to develop and verify a more accurate scoring system to predict the severity of AP. METHODS: In 302 patients with AP, we calculated BISAP and MEWS scores and conducted regression analyses on the relationships of BISAP scoring, RDW, MEWS, and serum Ca2+ with the severity of AP using single-factor logistics...
October 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28866089/the-association-between-non-alcoholic-fatty-liver-disease-and-atrial-fibrillation-a-meta-analysis
#20
Karn Wijarnpreecha, Boonphiphop Boonpheng, Charat Thongprayoon, Veeravich Jaruvongvanich, Patompong Ungprasert
BACKGROUND/OBJECTIVES: The association between non-alcoholic fatty liver disease (NAFLD) and atrial fibrillation (AF) has been suggested by recent epidemiological studies although the results were inconsistent. This meta-analysis was conducted to summarize all available data. METHODS: A comprehensive literature review was conducted using MEDLINE and EMBASE database through May 2017 to identify all studies that reported the risk of AF among patients with NAFLD versus those without NAFLD...
October 2017: Clinics and Research in Hepatology and Gastroenterology
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