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Journal of Ophthalmic Inflammation and Infection

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https://www.readbyqxmd.com/read/30515606/laser-flare-photometry-a-cost-effective-method-for-early-detection-of-endophthalmitis-after-intravitreal-injection-of-anti-vegf-agents
#1
Vânia Lages, Béatrice Gehrig, Carl P Herbort
BACKGROUND: Intravitreal injection of anti-vascular endothelial growth factor agents is the most common intraocular procedure worldwide, inevitably causing more cases of post-injection endophthalmitis. The purpose of this study was to evaluate the utility of laser flare photometry in monitoring inflammation after intravitreal injection of anti-vascular endothelial growth factor agents, particularly to detect early stage post-injection endophthalmitis. A retrospective case review was performed of all patients who underwent flare assessment by laser flare photometry before and after intravitreal injection of bevacizumab or aflibercept at the Centre for Ophthalmic Specialized Care in Lausanne, Switzerland, between January 2015 and May 2018...
December 4, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/30515585/syphilitic-uveitis-misdiagnosed-as-viral-retinitis-a-misleading-history
#2
Manisha Agarwal, Richa Ranjan, Lagan Paul, Deepa Sharma
BACKGROUND: Syphilitic uveitis is an infective uveitis and a great mimicker. Misdiagnosis can lead to delay in the specific treatment resulting in deterioration of uveitis and loss of vision. FINDINGS: A 38-year-old unmarried female presented with pain, redness, and blurring of vision in the left eye for the last 5 days. She denied history of any sexual exposure in the past. Anterior segment examination of the right eye was normal and the left eye showed keratic precipitates with anterior chamber cells and iris pigments on anterior lens capsule...
December 4, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/30460590/clinical-presentations-management-outcomes-and-diagnostic-dilemma-in-kocuria-endophthalmitis
#3
Vivek Pravin Dave, Joveeta Joseph, Avinash Pathengay, Rajeev R Pappuru
AIM: To describe the clinical presentations and management outcomes of Kocuria endophthalmitis and discuss diagnostic dilemmas DESIGN: Retrospective interventional comparative case series INTERVENTION: Eight unilateral cases with culture-proven Kocuria endophthalmitis from January 2013 to December 2017 underwent vitrectomy/vitreous biopsy and intravitreal antibiotic with or without additional procedures. The undiluted vitreous was subjected to microbiologic evaluation. MAIN OUTCOME MEASURES: The mean age at presentation, etiology, number of interventions, interval between inciting event and presentation, type of intravitreal antibiotic used, and anatomic and functional outcomes were reported...
November 20, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/30392069/atypical-white-dot-syndrome-with-choriocapillaris-ischemia-in-a-patient-with-latent-tuberculosis
#4
Sana Khochtali, Nesrine Abroug, Imen Ksiaa, Sourour Zina, Sonia Attia, Moncef Khairallah
BACKGROUND: White dot syndromes (WDS) are a group of idiopathic multifocal inflammatory conditions that can be recognized and distinguished by lesion morphology, other specific clinical features, imaging findings, and disease course. Our purpose is to describe an atypical case of WDS with choriocapillaris ischemia shown by multimodal imaging including swept-source OCT angiography (OCTA) in a 30-year-old woman with latent tuberculosis. FINDINGS: At presentation, visual acuity in the left eye was 20/500...
November 3, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/30357549/comparative-in-vitro-effectiveness-of-a-novel-contact-lens-multipurpose-solution-on-acanthamoeba-castellanii
#5
Alyssa C Fears, Rebecca C Metzinger, Stephanie Z Killeen, Robert S Reimers, Chad J Roy
BACKGROUND: A multipurpose contact lens cleaning solution (MPS) containing novel active ingredients under development was compared to two commercially available MPS solutions for effectiveness against Acanthamoeba isolates. METHODS: The Acanthamoeba isolate A. castellanii was propagated for trophozoite or cyst-containing cultures for the purpose of assessment of effectiveness of each MPS. An alamar blue-based cellular respiration assay was used to assess effectiveness against trophozoites; Trypan blue hemocytometer-based microscopic counts measured cysticidal effects...
October 24, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/30328571/acute-multifocal-retinitis-a-retrospective-review-of-35-cases
#6
Sana Khochtali, Salma Gargouri, Sourour Zina, Imen Ksiaa, Nesrine Abroug, Sonia Zaouali, Bechir Jelliti, Sonia Attia, Moncef Khairallah
BACKGROUND: Acute multifocal retinitis is a rare condition that has been considered to be often idiopathic. The purpose of this study was to analyze clinical features and causes of acute multifocal retinitis. RESULTS: This study is a retrospective review of the charts of 35 patients with acute multifocal retinitis. Patients with three or more retinal lesions in at least one eye, with at least one lesion of less than 500 μm in size were included. All patients had complete ophthalmological examination, fundus photography, and fluorescein angiography...
October 17, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/30327966/discovery-of-tear-biomarkers-in-children-with-chronic-non-infectious-anterior-uveitis-a-pilot-study
#7
Sheila T Angeles-Han, Steven Yeh, Purnima Patel, Duc Duong, Kirsten Jenkins, Kelly A Rouster-Stevens, Mekibib Altaye, Ndate Fall, Sherry Thornton, Sampath Prahalad, Gary N Holland
BACKGROUND: Biomarkers in easily obtained specimens that accurately predict uveitis in children with juvenile idiopathic arthritis (JIA) are needed. Aqueous humor has been studied for biomarkers, but is not routinely available. We evaluated tears from children with chronic anterior uveitis (CAU) for biomarkers reported in aqueous humor. In this pilot study, we used Schirmer strips to collect tears from seven children (nine eyes); three children had JIA- associated uveitis (JIA-U) and four had idiopathic disease (I-CAU)...
October 16, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/30317398/swept-source-oct-in-patients-with-multiple-evanescent-white-dot-syndrome
#8
Felipe Pereira, Luiz H Lima, Alexandre Gomes B de Azevedo, Claudio Zett, Michel E Farah, Rubens Belfort
BACKGROUND: Swept-source optical coherence tomography (SS-OCT) has a higher scanning rate and longer wavelength in comparison with spectral-domain OCT (SD-OCT), allowing an improved imaging of retinal vascular plexuses and choriocapillaris. The present two patients diagnosed with multiple evanescent white dot syndrome (MEWDS) underwent fundus autofluorescence (FAF), en-face SS-OCT, and SS-OCT angiography (OCTA) imaging, and its features were described and correlated. RESULTS: The clinical and imaging findings of both cases were consistent with the diagnosis of MEWDS...
October 13, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/30306361/endogenous-endophthalmitis-a-9-year-retrospective-study-at-a-tertiary-referral-hospital-in-malaysia
#9
Rosiah Muda, Valarmathy Vayavari, Deivanai Subbiah, Hamisah Ishak, Azian Adnan, Shelina Oli Mohamed
BACKGROUND: The objective of this study was to determine the clinical presentation, systemic risk factors, source of infective microorganism, treatment outcomes, and prognostic indicators of endogenous endophthalmitis at a main tertiary referral hospital for uveitis in Malaysia. A retrospective review of medical records of 120 patients (143 eyes) with endogenous endophthalmitis over a period of 9 years between January 2007 and December 2015 was undertaken. RESULTS: Identifiable systemic risk factors were present in 79...
October 11, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/30306353/filamentous-gram-negative-bacteria-masquerading-as-actinomycetes-in-infectious-endophthalmitis-a-review-of-three-cases
#10
Joveeta Joseph, Savitri Sharma, Vivek Pravin Dave
BACKGROUND: To report microbiological diagnostic dilemma posed by observation of unusual morphology of bacteria in the vitreous sample of a series of three cases of bacterial endophthalmitis. RESULTS: A non-comparative, descriptive case series is described. All three cases presented to the retina-vitreous clinic with a clinical diagnosis of acute endophthalmitis between January and April 2018. Two patients had a past history of cataract surgery, and one had antecedent trauma within 1-2 days of presentation...
October 11, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/30209691/an-update-on-inflammatory-choroidal-neovascularization-epidemiology-multimodal-imaging-and-management
#11
REVIEW
Aniruddha Agarwal, Alessandro Invernizzi, Rohan Bir Singh, William Foulsham, Kanika Aggarwal, Sabia Handa, Rupesh Agrawal, Carlos Pavesio, Vishali Gupta
Inflammatory choroidal neovascular membranes are challenging to diagnose and manage. A number of uveitic entities may be complicated by the development of choroidal neovascularization leading to a decrease in central visual acuity. In conditions such as punctate inner choroidopathy, development of choroidal neovascularization is extremely common and must be suspected in all cases. On the other hand, in patients with conditions such as serpiginous choroiditis, and multifocal choroiditis, it may be difficult to differentiate between inflammatory choroiditis lesions and choroidal neovascularization...
September 12, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/30141181/rituximab-and-bilateral-hsv-epithelial-keratitis-in-a-patient-with-mucous-membrane-pemphigoid
#12
LETTER
W Bernauer, S Schuler, L Borradori
BACKGROUND: B cell depleting therapy is widely used for lymphoproliferative diseases and immune-mediated disorders, including mucous membrane pemphigoid. The latter is an autoimmune blistering disease affecting predominantly the mucosae potentially associated with devastating complications. METHODS: A 71-year-old patient with severe mucous membrane pemphigoid involving ocular, oral pharyngeal and laryngeal involvement is described. To control the disease, the patient was given rituximab therapy in combination with oral corticosteroids...
August 23, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/30076485/necrotising-retinopathy-like-lesions-as-a-manifestation-of-ocular-sarcoidosis
#13
Florence Rasquin, Nacima Kisma, Laure Van Bol
BACKGROUND: A 56-year-old Caucasian man presented with a 2-weeks history of decreased vision in the right eye. Vitritis, papillitis, cystoid macular oedema and inferior diffuse retinal infiltration were noticed. Extensive blood work-up, anterior chamber paracentesis with polymerase chain reaction (PCR) and Goldmann-Witmer coefficient, tuberculin skin test (PPD-test), fluorodeoxyglucose Positron Emission Tomography CT scan (FDG-PET/CT), lymph node biopsy and pars plana vitrectomy were performed...
August 3, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29971681/specialty-management-differences-of-syphilis-and-toxoplasmosis-surrounding-pregnancy-a-prospective-cross-sectional-study
#14
Jared S Fredrickson, Jennifer Holmes, Jennifer N Cathcart, Anne M Lynch, Jason R Kolfenbach, Alan G Palestine
BACKGROUND: Syphilis and toxoplasmosis are two infectious conditions that can occur during pregnancy. Both these diseases can have ocular manifestations and thus are treated by ophthalmologists and obstetricians. We hypothesized that specialty training would affect the way physicians selected therapy. RESULTS: A total of 209 uveitis specialists and approximately 2500 obstetricians across the USA were surveyed using an online questionnaire distributed via listserv and social media posts...
July 3, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29915970/comparison-of-surgical-outcomes-of-trabeculectomy-ahmed-shunt-and-baerveldt-shunt-in-uveitic-glaucoma
#15
Audrey Chow, Bruce Burkemper, Rohit Varma, Damien C Rodger, Narsing Rao, Grace M Richter
BACKGROUND: Uveitis is defined as a collection of syndromes involving intraocular inflammation which can lead to pain, tissue damage, and vision loss. Ophthalmic surgery in uveitis patients can be challenging due to inflammation-induced fibrosis and scarring. Trabeculectomy and implantation of glaucoma drainage devices (aqueous shunts) have been used in surgical management of uveitic glaucoma, however there is a paucity of literature examining the comparative results of these entities in this unique setting...
June 18, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29904801/toxoplasma-gondii-bradyzoites-and-tachyzoites-isolation-from-vitreous-of-atypical-necrotizing-retinitis
#16
Ranju Kharel Sitaula, Sagun Narayan Joshi, Ranjit Sah, Sushila Khadka, Anadi Khatri Kc, Bharat Mani Pokharel
BACKGROUND: Detection of Toxoplasma gondii cysts in vitreous of immunocompetent patient with necrotizing retinitis is extremely rare. We herein report the isolation of Toxoplasma bradyzoites and tachyzoites from the vitreous of healthy person. RESULTS: A 19-year-old immunocompetent female presented with sudden loss of vision in left eye since 1 week. The BCVA was 6/6 and HM in right and left eye. The left eye finding was suggestive of diffuse necrotizing retinitis with retinal detachment...
June 15, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29671151/an-atypical-case-of-neurosarcoidosis-presenting-with-neovascular-glaucoma
#17
REVIEW
Melissa Vereecken, Karolien Hollanders, Deborah De Bruyn, Virginie Ninclaus, Julie De Zaeytijd, Ilse De Schryver
BACKGROUND: Sarcoidosis, a multisystem, granulomatous disorder, sometimes manifests with a neuro-ophthalmic subtype. The latter can pose a diagnostic challenge, especially when ocular symptoms appear before systemic involvement, as the clinical picture then can be non-specific and systemic laboratory and standard imaging investigations can be negative. FINDINGS: A 71-year-old woman presented with a 4-month history of sudden-onset visual loss in the left eye. Slit lamp examination revealed anterior chamber cells, iris, and angle neovascularization...
April 18, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29666980/epidemiology-of-uveitis-in-a-us-population-based-study
#18
Marta Mora González, Marissé Masís Solano, Travis C Porco, Catherine E Oldenburg, Nisha R Acharya, Shan C Lin, Matilda F Chan
BACKGROUND: The purpose of this study is to assess the relationship between self-reported uveitis and purported demographic and clinical risk factors, using an American adult population extracted from the National Health and Nutrition Examination Survey (NHANES) for the years 2009 and 2010. This is a cross-sectional, population-based study using a sample of 5106 subjects between 20 and 69 years old. The main outcome for our study was the self-report of a diagnosis of uveitis. The demographic analysis included age, gender, and ethnicity...
April 17, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29589220/ocular-involvement-in-melioidosis-a-23-year-retrospective-review
#19
Sasi Yaisawang, Somkiat Asawaphureekorn, Ploenchan Chetchotisakd, Surasakdi Wongratanacheewin, Peerapat Pakdee
BACKGROUND: Ocular involvement in melioidosis is rare and has devastating outcomes. Although there have been few reports on the condition, Khon Kaen, a city in northeast Thailand, has been called the "capital of melioidosis" due to the high prevalence of the condition in the region. We retrospectively reviewed all admitted cases of melioidosis with ocular involvement from the two largest hospitals in Khon Kaen. We reviewed cases from Srinagarind Hospital (a university hospital) of patients admitted between 1993 and 2016 and from Khon Kaen Hospital (a provincial hospital) of patients who presented from 2012 to 2016...
March 27, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29516199/keratoconus-like-tomographic-changes-in-a-case-of-recurrent-interstitial-keratitis
#20
Marie-Sophie Hanet, Annette Zimpfer, Sabine Lepper, Berthold Seitz
BACKGROUND: The purpose of this report was to describe a single case of recurrent interstitial keratitis in a young patient leading to keratoconus-like corneal changes. RESULTS: Over the 2 years follow-up, the patient developed clinical signs of keratoconus with Vogt's striae, Fleischer Ring and paracentral stromal thinning in the affected eye only. The tomographic measurements revealed a rapid reduction of corneal thickness from 581 to 303 μm and an irregular steepening of the pathological cornea...
March 7, 2018: Journal of Ophthalmic Inflammation and Infection
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