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Fluids and Barriers of the CNS

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https://www.readbyqxmd.com/read/29110676/current-research-into-brain-barriers-and-the-delivery-of-therapeutics-for-neurological-diseases-a-report-on-cns-barrier-congress-london-uk-2017
#1
REVIEW
John Greenwood, Margareta Hammarlund-Udenaes, Hazel C Jones, Alan W Stitt, Roosmarijn E Vandenbrouke, Ignacio A Romero, Matthew Campbell, Gert Fricker, Birger Brodin, Heiko Manninga, Pieter J Gaillard, Markus Schwaninger, Carl Webster, Krzysztof B Wicher, Michel Khrestchatisky
This is a report on the CNS barrier congress held in London, UK, March 22-23rd 2017 and sponsored by Kisaco Research Ltd. The two 1-day sessions were chaired by John Greenwood and Margareta Hammarlund-Udenaes, respectively, and each session ended with a discussion led by the chair. Speakers consisted of invited academic researchers studying the brain barriers in relation to neurological diseases and industry researchers studying new methods to deliver therapeutics to treat neurological diseases. We include here brief reports from the speakers...
November 7, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29089037/revisiting-atenolol-as-a-low-passive-permeability-marker
#2
Xiaomei Chen, Tim Slättengren, Elizabeth C M de Lange, David E Smith, Margareta Hammarlund-Udenaes
BACKGROUND: Atenolol, a hydrophilic beta blocker, has been used as a model drug for studying passive permeability of biological membranes such as the blood-brain barrier (BBB) and the intestinal epithelium. However, the extent of S-atenolol (the active enantiomer) distribution in brain has never been evaluated, at equilibrium, to confirm that no transporters are involved in its transport at the BBB. METHODS: To assess whether S-atenolol, in fact, depicts the characteristics of a low passive permeable drug at the BBB, a microdialysis study was performed in rats to monitor the unbound concentrations of S-atenolol in brain extracellular fluid (ECF) and plasma during and after intravenous infusion...
October 31, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29047355/hyperdynamic-csf-motion-profiles-found-in-idiopathic-normal-pressure-hydrocephalus-and-alzheimer-s-disease-assessed-by-fluid-mechanics-derived-from-magnetic-resonance-images
#3
Ken Takizawa, Mitsunori Matsumae, Naokazu Hayashi, Akihiro Hirayama, Satoshi Yatsushiro, Kagayaki Kuroda
BACKGROUND: Magnetic resonance imaging (MRI) does not only ascertain morphological features, but also measures physiological properties such as fluid velocity or pressure gradient. The purpose of this study was to investigate cerebrospinal fluid (CSF) dynamics in patients with morphological abnormalities such as enlarged brain ventricles and subarachnoid spaces. We used a time-resolved three dimensional phase contrast (3D-PC) MRI technique to quantitatively evaluate CSF dynamics in the Sylvian aqueduct of healthy elderly individuals and patients with either idiopathic normal pressure hydrocephalus (iNPH) or Alzheimer's disease (AD) presenting with ventricular enlargement...
October 18, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29029630/correction-to-correlation-of-csf-flow-using-phase-contrast-mri-with-ventriculomegaly-and-csf-opening-pressure-in-mucopolysaccharidoses
#4
Amauri Dalla Corte, Carolina F M de Souza, Maurício Anés, Fabio K Maeda, Armelle Lokossou, Leonardo M Vedolin, Maria Gabriela Longo, Monica M Ferreira, Solanger G P Perrone, Olivier Balédent, Roberto Giugliani
After publication of the article [1], it has been brought to our attention that the full funding acknowledgement is missing from the original article.
October 13, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28974245/dose-escalation-study-of-intravenous-and-intra-arterial-n-acetylcysteine-for-the-prevention-of-oto-and-nephrotoxicity-of-cisplatin-with-a-contrast-induced-nephropathy-model-in-patients-with-renal-insufficiency
#5
Edit Dósa, Krisztina Heltai, Tamás Radovits, Gabriella Molnár, Judit Kapocsi, Béla Merkely, Rongwei Fu, Nancy D Doolittle, Gerda B Tóth, Zachary Urdang, Edward A Neuwelt
BACKGROUND: Cisplatin neuro-, oto-, and nephrotoxicity are major problems in children with malignant tumors, including medulloblastoma, negatively impacting educational achievement, socioemotional development, and overall quality of life. The blood-labyrinth barrier is somewhat permeable to cisplatin, and sensory hair cells and cochlear supporting cells are highly sensitive to this toxic drug. Several chemoprotective agents such as N-acetylcysteine (NAC) were utilized experimentally to avoid these potentially serious and life-long side effects, although no clinical phase I trial was performed before...
October 3, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28950883/characterization-of-cardiac-and-respiratory-driven-cerebrospinal-fluid-motion-based-on-asynchronous-phase-contrast-magnetic-resonance-imaging-in-volunteers
#6
Ken Takizawa, Mitsunori Matsumae, Saeko Sunohara, Satoshi Yatsushiro, Kagayaki Kuroda
BACKGROUND: A classification of cardiac- and respiratory-driven components of cerebrospinal fluid (CSF) motion has been demonstrated using echo planar imaging and time-spatial labeling inversion pulse techniques of magnetic resonance imaging (MRI). However, quantitative characterization of the two motion components has not been performed to date. Thus, in this study, the velocities and displacements of the waveforms of the two motions were quantitatively evaluated based on an asynchronous two-dimensional (2D) phase-contrast (PC) method followed by frequency component analysis...
September 27, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28918752/correlation-of-csf-flow-using-phase-contrast-mri-with-ventriculomegaly-and-csf-opening-pressure-in-mucopolysaccharidoses
#7
Amauri Dalla Corte, Carolina F M de Souza, Maurício Anés, Fabio K Maeda, Armelle Lokossou, Leonardo M Vedolin, Maria Gabriela Longo, Monica M Ferreira, Solanger G P Perrone, Olivier Balédent, Roberto Giugliani
BACKGROUND: Very little is known about the incidence and prevalence of hydrocephalus in patients with mucopolysaccharidoses (MPS). The biggest challenge is to distinguish communicating hydrocephalus from ventricular dilatation secondary to brain atrophy, because both conditions share common clinical and neuroradiological features. The main purpose of this study is to assess the relationship between ventriculomegaly, brain and cerebrospinal fluid (CSF) volumes, aqueductal and cervical CSF flows, and CSF opening pressure in MPS patients, and to provide potential biomarkers for abnormal CSF circulation...
September 18, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28899431/the-role-of-perfusion-and-diffusion-mri-in-the-assessment-of-patients-affected-by-probable-idiopathic-normal-pressure-hydrocephalus-a-cohort-prospective-preliminary-study
#8
Francesco Tuniz, Maria Caterina Vescovi, Daniele Bagatto, Daniela Drigo, Maria Cristina De Colle, Marta Maieron, Miran Skrap
BACKGROUND: Invasive tests measuring resistance to cerebral spinal fluid (CSF) outflow and the effect of temporary drainage of CSF are used to select candidates affected by idiopathic normal pressure hydrocephalus (iNPH) for shunt surgery. Neither test, however, completely excludes patients from treatment. Perfusion and diffusion magnetic resonance imaging (MRI) are non-invasive techniques that might be of value in selecting patients for surgical treatment and understanding brain changes in iNPH patients...
September 12, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28806983/profiling-of-metalloprotease-activities-in-cerebrospinal-fluids-of-patients-with-neoplastic-meningitis
#9
Catharina Conrad, Kristina Dorzweiler, Miles A Miller, Douglas A Lauffenburger, Herwig Strik, Jörg W Bartsch
BACKGROUND: Neoplastic invasion into leptomeninges and subarachnoid space, resulting in neoplastic meningitis (NM) is a fatal complication of advanced solid and hematological neoplasms. Identification of malignant involvement of the cerebrospinal fluid (CSF) early in the disease course has crucial prognostic and therapeutic implications, but remains challenging. As indicators of extracellular matrix (ECM) degradation and breakdown of the blood-brain-barrier, Matrix Metalloproteases (MMPs) and A Disintegrin and Metalloproteases (ADAMs) are potential analytes for cerebral pathophysiology and metastatic dissemination of tumor cells into the CSF...
August 14, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28774343/effect-of-shear-stress-on-ipsc-derived-human-brain-microvascular-endothelial-cells-dhbmecs
#10
Jackson G DeStefano, Zinnia S Xu, Ashley J Williams, Nahom Yimam, Peter C Searson
BACKGROUND: The endothelial cells that form the lumen of capillaries and microvessels are an important component of the blood-brain barrier. Cell phenotype is regulated by transducing a range of biomechanical and biochemical signals in the local microenvironment. Here we report on the role of shear stress in modulating the morphology, motility, proliferation, apoptosis, and protein and gene expression, of confluent monolayers of human brain microvascular endothelial cells derived from induced pluripotent stem cells...
August 4, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28701191/blood-brain-barrier-and-foetal-onset-hydrocephalus-with-a-view-on-potential-novel-treatments-beyond-managing-csf-flow
#11
REVIEW
M Guerra, J L Blázquez, E M Rodríguez
Despite decades of research, no compelling non-surgical therapies have been developed for foetal hydrocephalus. So far, most efforts have pointed to repairing disturbances in the cerebrospinal fluid (CSF) flow and to avoid further brain damage. There are no reports trying to prevent or diminish abnormalities in brain development which are inseparably associated with hydrocephalus. A key problem in the treatment of hydrocephalus is the blood-brain barrier that restricts the access to the brain for therapeutic compounds or systemically grafted cells...
July 13, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28679427/comparison-of-the-sagittal-sinus-cross-sectional-area-between-patients-with-multiple-sclerosis-hydrocephalus-intracranial-hypertension-and-spontaneous-intracranial-hypotension-a-surrogate-marker-of-venous-transmural-pressure
#12
Grant A Bateman, Jeannette Lechner-Scott, Ross Copping, Christopher Moeskops, Swee Leong Yap
There is evidence that patients with multiple sclerosis (MS) and hydrocephalus share some common pathophysiological mechanisms. Alterations in CSF pressure are known to affect cerebral venous sinus geometry. To further explore these mechanisms, we measured the superior sagittal sinus (SSS) cross-sectional area 3 cm above the torcular using T2 images in 20 MS, 10 spontaneous intracranial hypotension (SIH), 21 hydrocephalus and 20 idiopathic intracranial hypertension (IIH) patients and compared with 20 matched controls...
July 6, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28623925/human-jugular-vein-collapse-in-the-upright-posture-implications-for-postural-intracranial-pressure-regulation
#13
Petter Holmlund, Elias Johansson, Sara Qvarlander, Anders Wåhlin, Khalid Ambarki, Lars-Owe D Koskinen, Jan Malm, Anders Eklund
BACKGROUND: Intracranial pressure (ICP) is directly related to cranial dural venous pressure (P dural ). In the upright posture, P dural is affected by the collapse of the internal jugular veins (IJVs) but this regulation of the venous pressure has not been fully understood. A potential biomechanical description of this regulation involves a transmission of surrounding atmospheric pressure to the internal venous pressure of the collapsed IJVs. This can be accomplished if hydrostatic effects are cancelled by the viscous losses in these collapsed veins, resulting in specific IJV cross-sectional areas that can be predicted from flow velocity and vessel inclination...
June 17, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28929972/abstracts-from-hydrocephalus-2016
#14
A Adam, J Robison, J Lu, R Jose, N Badran, T Vivas-Buitrago, D Rigamonti, A Sattar, O Omoush, M Hammad, M Dawood, M Maghaslah, T Belcher, K Carson, J Hoffberger, I Jusué Torres, S Foley, S Yasar, Q A Thai, J Wemmer, P Klinge, L Al-Mutawa, H Al-Ghamdi, K A Carson, M Asgari, D de Zélicourt, V Kurtcuoglu, S Garnotel, S Salmon, O Balédent, A Lokossou, G Page, L Balardy, Z Czosnyka, P Payoux, E A Schmidt, M Zitoun, M A Sevestre, N Alperin, I Baudracco, C Craven, S Matloob, S Thompson, P Haylock Vize, L Thorne, L D Watkins, A K Toma, Karl Bechter, A C Pong, L Jugé, L E Bilston, S Cheng, W Bradley, F Hakim, J F Ramón, M F Cárdenas, J S Davidson, C García, D González, S Bermúdez, N Useche, J A Mejía, P Mayorga, F Cruz, C Martinez, M C Matiz, M Vallejo, K Ghotme, H A Soto, D Riveros, A Buitrago, M Mora, L Murcia, S Bermudez, D Cohen, D Dasgupta, C Curtis, L Domínguez, A J Remolina, M A Grijalba, K J Whitehouse, R J Edwards, A Eleftheriou, F Lundin, K N Fountas, E Z Kapsalaki, H F Smisson, J S Robinson, M J Fritsch, W Arouk, M Garzon, M Kang, K Sandhu, D Baghawatti, K Aquilina, G James, D Thompson, M Gehlen, M Schmid Daners, A Eklund, J Malm, D Gomez, M Guerra, M Jara, M Flores, K Vío, I Moreno, S Rodríguez, E Ortega, E M Rodríguez, J P McAllister, M M Guerra, D M Morales, D Sival, A Jimenez, D D Limbrick, M Ishikawa, S Yamada, K Yamamoto, A Junkkari, A Häyrinen, T Rauramaa, H Sintonen, O Nerg, A M Koivisto, R P Roine, H Viinamäki, H Soininen, A Luikku, J E Jääskeläinen, V Leinonen, U Kehler, O Lilja-Lund, K Kockum, E M Larsson, K Riklund, L Söderström, P Hellström, K Laurell, M Kojoukhova, A Sutela, R Vanninen, K I Vanha, M Timonen, J Rummukainen, V Korhonen, S Helisalmi, E Solje, A M Remes, J Huovinen, J Paananen, M Hiltunen, M Kurki, B Martin, F Loth, M Luciano, A J Luikku, A Hall, S K Herukka, J Mattila, J Lötjönen, I Alafuzoff, I Jurjević, M Miyajima, M Nakajima, H Murai, T Shin, D Kawaguchi, C Akiba, I Ogino, K Karagiozov, H Arai, R C Reis, M J Teixeira, C G Valêncio, D da Vigua, L Almeida-Lopes, M W Mancini, F C G Pinto, R H Maykot, G Calia, J Tornai, S S S Silvestre, G Mendes, V Sousa, B Bezerra, P Dutra, P Modesto, M F Oliveira, C E Petitto, H Pulhorn, A Chandran, C McMahon, A S Rao, M Jumaly, D Solomon, A Moghekar, N Relkin, M Hamilton, H Katzen, M Williams, T Bach, S Zuspan, R Holubkov, A Rigamonti, G Clemens, P Sharkey, A Sanyal, E Sankey, K Rigamonti, S Naqvi, A Hung, E Schmidt, F Ory-Magne, P Gantet, A Guenego, A C Januel, P Tall, N Fabre, L Mahieu, C Cognard, L Gray, J A Buttner-Ennever, K Takagi, K Onouchi, S D Thompson, L D Thorne, H M Tully, T L Wenger, W A Kukull, D Doherty, W B Dobyns, D Moran, S Vakili, M A Patel, B Elder, C R Goodwin, J A Crawford, M V Pletnikov, J Xu, A Blitz, D A Herzka, H Guerrero-Cazares, A Quiñones-Hinojosa, S Mori, P Saavedra, H Treviño, K Maitani, W C Ziai, V Eslami, S Nekoovaght-Tak, R Dlugash, G Yenokyan, N McBee, D F Hanley
No abstract text is available yet for this article.
June 7, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28577579/patterns-of-relapse-in-primary-central-nervous-system-lymphoma-inferences-regarding-the-role-of-the-neuro-vascular-unit-and-monoclonal-antibodies-in-treating-occult-cns-disease
#15
Prakash Ambady, Rongwei Fu, Joao Prola Netto, Cymon Kersch, Jenny Firkins, Nancy D Doolittle, Edward A Neuwelt
BACKGROUND AND PURPOSE: The radiologic features and patterns of primary central nervous system lymphoma (PCNSL) at initial presentation are well described. High response rates can be achieved with first-line high-dose methotrexate (HD-MTX) based regimens, yet many relapse within 2 years of diagnosis. We describe the pattern of relapse and review the potential mechanisms involved in relapse. METHODS: We identified 78 consecutive patients who attained complete radiographic response (CR) during or after first-line treatment for newly diagnosed PCNSL (CD20+, diffuse large B cell type)...
June 2, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28521764/barrier-dysfunction-or-drainage-reduction-differentiating-causes-of-csf-protein-increase
#16
Mahdi Asgari, Diane A de Zélicourt, Vartan Kurtcuoglu
BACKGROUND: Cerebrospinal fluid (CSF) protein analysis is an important element in the diagnostic chain for various central nervous system (CNS) pathologies. Among multiple existing approaches to interpreting measured protein levels, the Reiber diagram is particularly robust with respect to physiologic inter-individual variability, as it uses multiple subject-specific anchoring values. Beyond reliable identification of abnormal protein levels, the Reiber diagram has the potential to elucidate their pathophysiologic origin...
May 18, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28486988/cerebrospinal-fluid-a%C3%AE-42-t-tau-and-p-tau-levels-in-the-differential-diagnosis-of-idiopathic-normal-pressure-hydrocephalus-a-systematic-review-and-meta-analysis
#17
REVIEW
Zhongyun Chen, Chunyan Liu, Jie Zhang, Norman Relkin, Yan Xing, Yanfeng Li
OBJECTIVES: The purpose of this systematic review and meta-analysis was to evaluate the performance of cerebrospinal fluid (CSF) beta amyloid 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) as potential diagnostic biomarkers for idiopathic normal-pressure hydrocephalus (iNPH) and to assess their utility indistinguishing patients with iNPH from those with Alzheimer disease (AD) and healthy normal controls. METHODS: Studies were identified by searching PubMed, Embase, the Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wanfang Chinese Periodical Database, VIP Chinese database, and Chinese Bio-medicine Database (CBM) before August 2016...
May 10, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28457227/nih-workshop-report-on-the-trans-agency-blood-brain-interface-workshop-2016-exploring-key-challenges-and-opportunities-associated-with-the-blood-brain-and-their-interface
#18
REVIEW
Margaret J Ochocinska, Berislav V Zlokovic, Peter C Searson, A Tamara Crowder, Richard P Kraig, Julia Y Ljubimova, Todd G Mainprize, William A Banks, Ronald Q Warren, Andrei Kindzelski, William Timmer, Christina H Liu
A trans-agency workshop on the blood-brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the Combat Casualty Care Research Program at the Department of Defense, was conducted in Bethesda MD on June 7-8, 2016. The workshop was structured into four sessions: (1) blood sciences; (2) exosome therapeutics; (3) next generation in vitro blood-brain barrier (BBB) models; and (4) BBB delivery and targeting. The first day of the workshop focused on the physiology of the blood and neuro-vascular unit, blood or biofluid-based molecular markers, extracellular vesicles associated with brain injury, and how these entities can be employed to better evaluate injury states and/or deliver therapeutics...
May 1, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28427421/cerebrospinal-fluid-csf-biomarkers-of-iron-status-are-associated-with-csf-viral-load-antiretroviral-therapy-and-demographic-factors-in-hiv-infected-adults
#19
Stephanie M Patton, Quan Wang, Todd Hulgan, James R Connor, Peilin Jia, Zhongming Zhao, Scott L Letendre, Ronald J Ellis, William S Bush, David C Samuels, Donald R Franklin, Harpreet Kaur, Jennifer Iudicello, Igor Grant, Asha R Kallianpur
BACKGROUND: HIV-associated neurocognitive disorder (HAND) remains common, despite antiretroviral therapy (ART). HIV dysregulates iron metabolism, but cerebrospinal fluid (CSF) levels of iron and iron-transport proteins in HIV-infected (HIV+) persons are largely unknown. The objectives of this study were to characterize CSF iron-related biomarkers in HIV+ adults and explore their relationships to known predictors of HAND. METHODS: We quantified total iron, transferrin and heavy-chain (H)-ferritin by immunoassay in CSF sampled by lumbar puncture in 403 HIV+ participants in a multi-center, observational study and evaluated biomarker associations with demographic and HIV-related correlates of HAND [e...
April 21, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28420385/frontotemporal-dementia-as-a-comorbidity-to-idiopathic-normal-pressure-hydrocephalus-inph-a-short-review-of-literature-and-an-unusual-case
#20
REVIEW
V E Korhonen, E Solje, N M Suhonen, T Rauramaa, R Vanninen, A M Remes, V Leinonen
Behavioural variant frontotemporal dementia (bvFTD) and idiopathic normal pressure hydrocephalus (iNPH) are neurodegenerative diseases that can present with similar symptoms. These include decline in executive functions, psychomotor slowness, and behavioural and personality changes. Ventricular enlargement is a key radiological finding in iNPH that may also be present in bvFTD caused by the C9ORF72 expansion mutation. Due to this, bvFTD has been hypothesized as a potential comorbidity to iNPH but bvFTD patients have never been identified in studies focusing in clinical comorbidities with iNPH...
April 19, 2017: Fluids and Barriers of the CNS
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