Isabella Karlsson, Xin Zhou, Raquela Thomas, Allorie T Smith, Michael Y Bonner, Pooja Bakshi, Ajay K Banga, J Phillip Bowen, Ghassan Qabaja, Shavon L Ford, Matthew D Ballard, Kimberly S Petersen, Xuechen Li, Guangping Chen, Besim Ogretmen, Jin Zhang, E Blake Watkins, Rebecca S Arnold, Jack L Arbiser
BACKGROUND: (-)-Solenopsin A is a piperidine alkaloid that is a component of the venom of the fire ant Solenopsis invicta. Previously, we have demonstrated that solenopsin exhibit anti-angiogenic activity and downregulate phosphoinositol-3 kinase (PI3K) in the p53 deficient renal cell carcinoma cell line 786-O. Solenopsin has structural similarities to ceramide, a major endogenous regulator of cell signaling and cancer therapy induced apoptosis. METHODS: Different analogs of solenopsin were synthesized in order to explore structure-activity relationships...
2015: Vascular Cell