journal
MENU ▼
Read by QxMD icon Read
search

Vascular Cell

journal
https://www.readbyqxmd.com/read/27790365/normal-endothelial-but-impaired-arterial-development-in-map-kinase-activated-protein-kinase-2-mk2-deficient-mice
#1
L Christian Napp, Olga Jabs, Anna Höckelmann, Jochen Dutzmann, Piyush R Kapopara, Daniel G Sedding, Matthias Gaestel, Johann Bauersachs, Udo Bavendiek
Angiogenesis is a fundamental process during development and disease, and many details of the underlying molecular and cellular mechanisms are incompletely understood. Mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (MK2), a major downstream target of p38 MAPK, has recently been identified as a regulator of Interleukin 1β dependent angiogenesis in vivo, and in vitro data suggest a role of MK2 for VEGF-dependent angiogenic processes in endothelial cells. We thus hypothesized that MK2 plays a role during physiological vascular development in vivo...
2016: Vascular Cell
https://www.readbyqxmd.com/read/27547374/angiogenic-and-anti-inflammatory-properties-of-micro-fragmented-fat-tissue-and-its-derived-mesenchymal-stromal-cells
#2
Valentina Ceserani, Anna Ferri, Angiola Berenzi, Anna Benetti, Emilio Ciusani, Luisa Pascucci, Cinzia Bazzucchi, Valentina Coccè, Arianna Bonomi, Augusto Pessina, Erica Ghezzi, Offer Zeira, Piero Ceccarelli, Silvia Versari, Carlo Tremolada, Giulio Alessandri
BACKGROUND: Adipose-derived mesenchymal stromal cells (Ad-MSCs) are a promising tool for advanced cell-based therapies. They are routinely obtained enzymatically from fat lipoaspirate (LP) as SVF, and may undergo prolonged ex vivo expansion, with significant senescence and decline in multipotency. Besides, these techniques have complex regulatory issues, thus incurring in the compelling requirements of GMP guidelines. Hence, availability of a minimally manipulated, autologous adipose tissue would have remarkable biomedical and clinical relevance...
2016: Vascular Cell
https://www.readbyqxmd.com/read/27175278/a-novel-endothelial-derived-anti-inflammatory-activity-significantly-inhibits-spontaneous-choroidal-neovascularisation-in-a-mouse-model
#3
Laura Paneghetti, Yin-Shan Eric Ng
BACKGROUND: Endothelial cells (EC) grown on collagen particles inhibit intimal hyperplasia in animal models when applied perivascularly, and this effect appears to be, at least in part, the result of EC-derived soluble factors that suppress local vascular inflammation. To elucidate the molecular basis of the therapeutic effects of EC grown on collagen particles, the anti-inflammatory activity of conditioned medium from these cells was characterized. METHODS: Human aortic EC (HAEC) and, for chromatin immunoprecipitation assays, human umbilical vein EC (HUVEC) were treated with tumor necrosis factor alpha (TNFα) in the presence of conditioned medium generated by HAEC grown on collagen particles (ECPCM), and the anti-inflammatory effects were evaluated by analysing the expression of the inflammation-related adhesion molecules E-selectin and vascular cell adhesion molecule-1 (VCAM-1)...
2016: Vascular Cell
https://www.readbyqxmd.com/read/26855770/a-novel-mutation-in-celsr1-is-associated-with-hereditary-lymphedema
#4
M L Gonzalez-Garay, M B Aldrich, J C Rasmussen, R Guilliod, P E Lapinski, P D King, E M Sevick-Muraca
BACKGROUND: Biological evidence reported in the literature supports the role of CELSR1 as being essential for valvular function in murine lymphatics. Yet thus far, there have been no variants in CELSR1 associated with lymphatic dysfunction in humans. CASE PRESENTATION: In this report, a rare early inactivating mutation in CELSR1 is found to be causal for non-syndromic, lower extremity lymphedema in a family across three generations. Near-infrared fluorescence lymphatic imaging shows that instead of being propelled within the lumen of well-defined lymphatic vessels, lymph moved in regions of both legs in an unusual fashion and within sheet-like structures...
2016: Vascular Cell
https://www.readbyqxmd.com/read/26629328/vascular-notch-proteins-and-notch-signaling-in-the-peri-implantation-mouse-uterus
#5
Carrie J Shawber, Lu Lin, Maria Gnarra, Mark V Sauer, Virginia E Papaioannou, Jan K Kitajewski, Nataki C Douglas
BACKGROUND: Angiogenesis is essential for uterine decidualization, the progesterone-mediated transformation of the uterus allowing embryo implantation and initiation of pregnancy. In the current study, we define the vasculature, expression of Notch proteins and Notch ligands, and Notch activity in both endothelial cells and vascular-associated mural cells of blood vessels in the pre-implantation endometrium and post-implantation decidua of the mouse uterus. METHODS: We used immunofluorescence to determine the expression of Notch in endothelial cells and mural cells by co-staining for the endothelial cell marker, CD31, the pan-mural cell marker, platelet-derived growth factor receptor beta (PDGFR-β), the pericyte markers, neural/glial antigen 2 (NG2) and desmin, or the smooth muscle cell marker, alpha smooth muscle actin (SMA)...
2015: Vascular Cell
https://www.readbyqxmd.com/read/26388991/mechanical-stretch-physiological-and-pathological-implications-for-human-vascular-endothelial-cells
#6
REVIEW
Nurul F Jufri, Abidali Mohamedali, Alberto Avolio, Mark S Baker
Vascular endothelial cells are subjected to hemodynamic forces such as mechanical stretch due to the pulsatile nature of blood flow. Mechanical stretch of different intensities is detected by mechanoreceptors on the cell surface which enables the conversion of external mechanical stimuli to biochemical signals in the cell, activating downstream signaling pathways. This activation may vary depending on whether the cell is exposed to physiological or pathological stretch intensities. Substantial stretch associated with normal physiological functioning is important in maintaining vascular homeostasis as it is involved in the regulation of cell structure, vascular angiogenesis, proliferation and control of vascular tone...
2015: Vascular Cell
https://www.readbyqxmd.com/read/26301087/variability-in-vascular-smooth-muscle-cell-stretch-induced-responses-in-2d-culture
#7
Laura-Eve Mantella, Adrian Quan, Subodh Verma
The pulsatile nature of blood flow exposes vascular smooth muscle cells (VSMCs) in the vessel wall to mechanical stress, in the form of circumferential and longitudinal stretch. Cyclic stretch evokes VSMC proliferation, apoptosis, phenotypic switching, migration, alignment, and vascular remodeling. Given that these responses have been observed in many cardiovascular diseases, a defined understanding of their underlying mechanisms may provide critical insight into the pathophysiology of cardiovascular derangements...
2015: Vascular Cell
https://www.readbyqxmd.com/read/26161255/therapeutic-manipulation-of-angiogenesis-with-mir-27b
#8
Dorina Veliceasa, Dauren Biyashev, Gangjian Qin, Sol Misener, Alexander Roy Mackie, Raj Kishore, Olga V Volpert
BACKGROUND: Multiple studies demonstrated pro-angiogenic effects of microRNA (miR)-27b. Its targets include Notch ligand Dll4, Sprouty (Spry)-2, PPARγ and Semaphorin (SEMA) 6A. miR-27 effects in the heart are context-dependent: although it is necessary for ventricular maturation, targeted overexpression in cardiomyocytes causes hypertrophy and dysfunction during development. Despite significant recent advances, therapeutic potential of miR-27b in cardiovascular disease and its effects in adult heart remain unexplored...
2015: Vascular Cell
https://www.readbyqxmd.com/read/26015865/solenopsin-a-and-analogs-exhibit-ceramide-like-biological-activity
#9
Isabella Karlsson, Xin Zhou, Raquela Thomas, Allorie T Smith, Michael Y Bonner, Pooja Bakshi, Ajay K Banga, J Phillip Bowen, Ghassan Qabaja, Shavon L Ford, Matthew D Ballard, Kimberly S Petersen, Xuechen Li, Guangping Chen, Besim Ogretmen, Jin Zhang, E Blake Watkins, Rebecca S Arnold, Jack L Arbiser
BACKGROUND: (-)-Solenopsin A is a piperidine alkaloid that is a component of the venom of the fire ant Solenopsis invicta. Previously, we have demonstrated that solenopsin exhibit anti-angiogenic activity and downregulate phosphoinositol-3 kinase (PI3K) in the p53 deficient renal cell carcinoma cell line 786-O. Solenopsin has structural similarities to ceramide, a major endogenous regulator of cell signaling and cancer therapy induced apoptosis. METHODS: Different analogs of solenopsin were synthesized in order to explore structure-activity relationships...
2015: Vascular Cell
https://www.readbyqxmd.com/read/25922663/decreased-circulating-and-neutrophil-mediated-vegf-a165-release-in-stable-long-term-cardiac-transplant-recipients
#10
Damien Vitiello, Diana Chaar, Paul-Eduard Neagoe, Anique Ducharme, Michel Carrier, Guy B Pelletier, Normand Racine, Mark Liszkowski, Martin G Sirois, Michel White
BACKGROUND: Vascular endothelial growth factor (VEGF) may play a role on the allograft remodelling following cardiac transplantation (CTx). We measured the circulating levels of VEGF-A165 concomitantly with the proinflammatory (Interleukin-8; IL-8), anti-inflammatory (IL-1 receptor antagonist; IL-1RA) and their release from neutrophils of CTx recipients. METHODS: Eighteen CTx recipients aged 49.6 ± 3.1 years, being transplanted for 145 ± 20 months were age-matched to 35 healthy control (HC) subjects...
2015: Vascular Cell
https://www.readbyqxmd.com/read/25914805/delta-like-4-mrna-is-regulated-by-adjacent-natural-antisense-transcripts
#11
Keguo Li, Tamjid Chowdhury, Padmanabhan Vakeel, Christopher Koceja, Venkatesh Sampath, Ramani Ramchandran
BACKGROUND: Recent evidence suggests that a majority of RNAs in the genome do not code for proteins. They are located in the sense (S) or antisense (AS) orientation and, to date, the functional significance of these non-coding RNAs (ncRNAs) is poorly understood. Here, we examined the relationship between S and AS transcripts in the regulation of a key angiogenesis gene, Delta-like 4 (Dll4). METHODS: Rapid Amplification of cDNA Ends (RACE) method was used to identify natural antisense transcripts in the Dll4 gene locus in murine and human endothelial cells, referred to as Dll4 Anti-Sense (Dll4-AS)...
2015: Vascular Cell
https://www.readbyqxmd.com/read/25705373/%C3%AE-actin-plays-a-key-role-in-endothelial-cell-motility-and-neovessel-maintenance
#12
Eddy Pasquier, Maria-Pia Tuset, Snega Sinnappan, Michael Carnell, Alexander Macmillan, Maria Kavallaris
BACKGROUND: Angiogenesis plays a crucial role in development, wound healing as well as tumour growth and metastasis. Although the general implication of the cytoskeleton in angiogenesis has been partially unravelled, little is known about the specific role of actin isoforms in this process. Herein, we aimed at deciphering the function of γ-actin in angiogenesis. METHODS: Localization of β- and γ-actin in vascular endothelial cells was investigated by co-immunofluorescence staining using monoclonal antibodies, followed by the functional analysis of γ-actin using siRNA...
2015: Vascular Cell
https://www.readbyqxmd.com/read/25653833/growth-factor-purification-and-delivery-systems-pads-for-therapeutic-angiogenesis
#13
Eric M George, Huiling Liu, Grant G Robinson, Fakhri Mahdi, Eddie Perkins, Gene L Bidwell
BACKGROUND: Therapeutic angiogenesis with vascular endothelial growth factor (VEGF), delivered either via recombinant protein infusion or via gene therapy, has shown promise in preclinical models of various diseases including myocardial infarction, renovascular disease, preeclampsia, and neurodegenerative disorders. However, dosing, duration of expression, and tissue specificity are challenges to VEGF gene therapy, and recombinant VEGF delivery suffers from extremely rapid plasma clearance, necessitating continuous infusion and/or direct injection at the site of interest...
2015: Vascular Cell
https://www.readbyqxmd.com/read/25973930/vascular-biology-2014-in-monterey-california-celebrating-20%C3%A2-years-of-navbo
#14
Ian W Tattersal, Henar Cuervo
A meeting report for Vascular Biology 2014, held in Monterey, California and organized by the North American Vascular Biology Organization (NAVBO).
2014: Vascular Cell
https://www.readbyqxmd.com/read/25785186/lymphangiogenesis-and-angiogenesis-during-human-fetal-pancreas-development
#15
Matthias S Roost, Liesbeth van Iperen, Ana de Melo Bernardo, Christine L Mummery, Françoise Carlotti, Eelco Jp de Koning, Susana M Chuva de Sousa Lopes
BACKGROUND: The complex endocrine and exocrine functionality of the human pancreas depends on an efficient fluid transport through the blood and the lymphatic vascular systems. The lymphatic vasculature has key roles in the physiology of the pancreas and in regulating the immune response, both important for developing successful transplantation and cell-replacement therapies to treat diabetes. However, little is known about how the lymphatic and blood systems develop in humans. Here, we investigated the establishment of these two vascular systems in human pancreas organogenesis in order to understand neovascularization in the context of emerging regenerative therapies...
2014: Vascular Cell
https://www.readbyqxmd.com/read/25520775/cellular-and-molecular-basis-of-venous-insufficiency
#16
Elizabeth S Pocock, Tom Alsaigh, Rafi Mazor, Geert W Schmid-Schönbein
Chronic venous disease (CVD) has a range of clinical presentations, including tortuous, distended veins in lower extremities, increasing skin pigmentation, and in severe cases ulceration of the affected skin. Venous insufficiency, a precursor to CVD characterized by improper return of blood from the lower extremities to the heart, must be studied in its earliest stages at a time when preventative measures could be applied in man. This underscores the need for basic research into biomarkers and genetic predisposing factors affecting the progression of venous disease...
2014: Vascular Cell
https://www.readbyqxmd.com/read/25473485/the-role-of-angiogenesis-in-the-pathology-of-multiple-sclerosis
#17
Justin Lengfeld, Tyler Cutforth, Dritan Agalliu
Angiogenesis, or the growth of new blood vessels from existing vasculature, is critical for the proper development of many organs. This process is inhibited and tightly regulated in adults, once endothelial cells have acquired organ-specific properties. Within the central nervous system (CNS), angiogenesis and acquisition of blood-brain barrier (BBB) properties by endothelial cells is essential for CNS function. However, the role of angiogenesis in CNS pathologies associated with impaired barrier function remains unclear...
2014: Vascular Cell
https://www.readbyqxmd.com/read/25309723/previously-differentiated-medial-vascular-smooth-muscle-cells-contribute-to-neointima-formation-following-vascular-injury
#18
Brian Paul Herring, April M Hoggatt, Christopher Burlak, Stefan Offermanns
BACKGROUND: The origins of neointimal smooth muscle cells that arise following vascular injury remains controversial. Studies have suggested that these cells may arise from previously differentiated medial vascular smooth muscle cells, resident stem cells or blood born progenitors. In the current study we examined the contribution of the previously differentiated vascular smooth muscle cells to the neointima that forms following carotid artery ligation. METHODS: We utilized transgenic mice harboring a cre recombinase-dependent reporter gene (mTmG)...
2014: Vascular Cell
https://www.readbyqxmd.com/read/25295160/lysosomal-drug-sequestration-as-a-mechanism-of-drug-resistance-in-vascular-sarcoma-cells-marked-by-high-csf-1r-expression
#19
Brandi H Gorden, Jhuma Saha, Ali Khammanivong, Gary K Schwartz, Erin B Dickerson
BACKGROUND: Human angiosarcoma and canine hemangiosarcoma are thought to arise from vascular tissue or vascular forming cells based upon their histological appearance. However, recent evidence indicates a hematopoietic or angioblastic cell of origin for these tumors. In support of this idea, we previously identified an endothelial-myeloid progenitor cell population with high expression of endothelial cell markers and the myeloid cell marker, colony stimulating factor 1 receptor (CSF-1R)...
2014: Vascular Cell
https://www.readbyqxmd.com/read/25243060/ageing-and-microvasculature
#20
REVIEW
Maria Giovanna Scioli, Alessandra Bielli, Gaetano Arcuri, Amedeo Ferlosio, Augusto Orlandi
A decline in the function of the microvasculature occurs with ageing. An impairment of endothelial properties represents a main aspect of age-related microvascular alterations. Endothelial dysfunction manifests itself through a reduced angiogenic capacity, an aberrant expression of adhesion molecules and an impaired vasodilatory function. Increased expression of adhesion molecules amplifies the interaction with circulating factors and inflammatory cells. The latter occurs in both conduit arteries and resistance arterioles...
2014: Vascular Cell
journal
journal
43432
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"