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Cellular Oncology (Dordrecht)

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https://www.readbyqxmd.com/read/29679238/identification-of-subsets-of-actionable-genetic-alterations-in-kras-mutant-lung-cancers-using-association-rule-mining
#1
Junior Tayou
BACKGROUND: Lung cancer is the leading cause of cancer-related death in both men and women. KRAS mutations occur in ~ 25% of patients with lung cancer, and the presence of these mutations is associated with a poor prognosis. Unfortunately, efforts to directly target KRAS or its associated downstream MAPK or PI3K/AKT/mTOR pathways have seen little or no benefits. Here, I hypothesize that KRAS-mutant tumors do not respond to KRAS pathway therapies due to the co-occurrence of other activated cell survival pathways and/or mechanisms...
April 20, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29667069/the-versatile-role-of-exosomes-in-cancer-progression-diagnostic-and-therapeutic-implications
#2
REVIEW
Vignesh Sundararajan, Fazlul H Sarkar, Thamil Selvee Ramasamy
BACKGROUND: Recent advances in cancer biology have highlighted the relevance of exosomes and nanovesicles as carriers of genetic and biological messages between cancer cells and their immediate and/or distant environments. It has been found that these molecular cues may play significant roles in cancer progression and metastasis. Cancer cells secrete exosomes containing diverse molecules that can be transferred to recipient cells and/or vice versa to induce a plethora of biological processes, including angiogenesis, metastasis formation, therapeutic resistance, epithelial-mesenchymal transition and epigenetic/stemness (re)programming...
April 17, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29633150/genetics-of-personalized-medicine-cancer-and-rare-diseases
#3
Inês Teles Siefers Alves, Manuel Condinho, Sónia Custódio, Bruna F Pereira, Rafael Fernandes, Vânia Gonçalves, Paulo J da Costa, Rafaela Lacerda, Ana Rita Marques, Patrícia Martins-Dias, Gonçalo R Nogueira, Ana Rita Neves, Patrícia Pinho, Raquel Rodrigues, Eva Rolo, Joana Silva, André Travessa, Rosário Pinto Leite, Ana Sousa, Luísa Romão
The 21st annual meeting of the Portuguese Society of Human Genetics (SPGH), organized by Luísa Romão, Ana Sousa and Rosário Pinto Leite, was held in Caparica, Portugal, from the 16th to the 18th of November 2017. Having entered an era in which personalized medicine is emerging as a paradigm for disease diagnosis, treatment and prevention, the program of this meeting intended to include lectures by leading national and international scientists presenting exceptional findings on the genetics of personalized medicine...
April 9, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29516288/genome-wide-analysis-of-endogenously-expressed-zeb2-binding-sites-reveals-inverse-correlations-between-zeb2-and-galnac-transferase-galnt3-in-human-tumors
#4
Pelin Balcik-Ercin, Metin Cetin, Irem Yalim-Camci, Gorkem Odabas, Nurettin Tokay, A Emre Sayan, Tamer Yagci
BACKGROUND: ZEB2 is a transcriptional repressor that regulates epithelial-to-mesenchymal transition (EMT) through binding to bipartite E-box motifs in gene regulatory regions. Despite the abundant presence of E-boxes within the human genome and the multiplicity of pathophysiological processes regulated during ZEB2-induced EMT, only a small fraction of ZEB2 targets has been identified so far. Hence, we explored genome-wide ZEB2 binding by chromatin immunoprecipitation-sequencing (ChIP-seq) under endogenous ZEB2 expression conditions...
March 7, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29497991/cancer-associated-fibroblasts-affect-breast-cancer-cell-gene-expression-invasion-and-angiogenesis
#5
Noemi Eiro, Lucía González, Anxo Martínez-Ordoñez, Belen Fernandez-Garcia, Luis O González, Sandra Cid, Francisco Dominguez, Román Perez-Fernandez, Francisco J Vizoso
PURPOSE: It has been reported that stromal cell features may affect the clinical outcome of breast cancer patients. Cancer associated fibroblasts (CAFs) represent one of the most abundant cell types within the breast cancer stroma. Here, we aimed to explore the influence of CAFs on breast cancer gene expression, as well as on invasion and angiogenesis. METHODS: qRT-PCR was used to evaluate the expression of several cancer progression related genes (S100A4, TGFβ, FGF2, FGF7, PDGFA, PDGFB, VEGFA, IL-6, IL-8, uPA, MMP2, MMP9, MMP11 and TIMP1) in the human breast cancer-derived cell lines MCF-7 and MDA-MB-231, before and after co-culture with CAFs...
March 1, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29480379/diagnostic-and-prognostic-relevance-of-salivary-microrna-21-125a-31-and-200a-levels-in-patients-with-oral-lichen-planus-a-short-report
#6
Masoumeh Mehdipour, Minoo Shahidi, Soheila Manifar, Soudeh Jafari, Fatemeh Mashhadi Abbas, Mahmood Barati, Hamed Mortazavi, Mohammad Shirkhoda, Amir Farzanegan, Zahra Elmi Rankohi
BACKGROUND: Oral lichen planus (OLP), a relatively common chronic inflammatory disease of the oral mucosa, is considered to be a premalignant disorder of the oral cavity. Previously, several biomarkers have been tested for their diagnostic potential. Here, we aimed to investigate the diagnostic potential of four miRNAs, miR-21, -125a, -31 and -200a, known to be involved in oral squamous cell carcinoma (OSCC) development, in the saliva of OLP patients as also their putative relation to OSCC development in these patients...
February 26, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29492901/inhibition-of-autophagy-enhances-denspm-induced-apoptosis-in-human-colon-cancer-cells-in-a-p53-independent-manner
#7
Ajda Coker Gurkan, Elif Damla Arisan, Pinar Obakan Yerlikaya, Halime Ilhan, Narcin Palavan Unsal
PURPOSE: One of the recently developed polyamine (PA) analogues, N 1 ,N11 -diethylnorspermine (DENSpm), has been found to act as an apoptotic inducer in melanoma, breast, prostate and colon cancer cells. Also, its potential to induce autophagy has been established. Unfolded protein responses and starvation of amino acids are known to trigger autophagy. As yet, however, the molecular mechanism underlying PA deficiency-induced autophagy is not fully clarified. Here, we aimed to determine the apoptotic effect of DENSpm after autophagy inhibition by 3-methyladenine (3-MA) or siRNA-mediated Beclin-1 silencing in colon cancer cells...
June 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29492900/a-hif-independent-cd133-mediated-mechanism-of-cisplatin-resistance-in-glioblastoma-cells
#8
Eroje M Ahmed, Gagori Bandopadhyay, Beth Coyle, Anna Grabowska
PURPOSE: Glioblastoma (GBM) is the commonest brain tumour in adults. A sub-population of cells within these tumours, known as cancer stem cells (CSCs), is thought to mediate their chemo-/radiotherapy resistance. CD133 is a cell surface marker that is used to identify and isolate GBM CSCs. However, its functional significance, as well as the relevant microenvironment in which to study CD133, have so far remained unknown. Here, we examined the effect of hypoxia on the expression of CD133 and on that of the hypoxia-related factors HIF-1α and HIF-2α, and the potential functional significance of CD133 expression on the acquisition of chemo-resistance by GBM cells...
June 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29568985/organ-specific-metastasis-of-breast-cancer-molecular-and-cellular-mechanisms-underlying-lung-metastasis
#9
REVIEW
Meysam Yousefi, Rahim Nosrati, Arash Salmaninejad, Sadegh Dehghani, Alireza Shahryari, Alihossein Saberi
BACKGROUND: Breast cancer (BC) is the most common type of cancer in women and the second cause of cancer-related mortality world-wide. The majority of BC-related deaths is due to metastasis. Bone, lung, brain and liver are the primary target sites of BC metastasis. The clinical implications and mechanisms underlying bone metastasis have been reviewed before. Given the fact that BC lung metastasis (BCLM) usually produces symptoms only after the lungs have been vastly occupied with metastatic tumor masses, it is of paramount importance for diagnostic and prognostic, as well as therapeutic purposes to comprehend the molecular and cellular mechanisms underlying BCLM...
April 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29470831/expression-and-function-of-immune-ligand-receptor-pairs-in-nk-cells-and-cancer-stem-cells-therapeutic-implications
#10
REVIEW
Ioannis A Voutsadakis
BACKGROUND: The interplay between the immune system and cancer cells has come to the forefront of cancer therapeutics, with novel immune blockade inhibitors being approved for the treatment of an increasing list of cancers. However, the majority of cancer patients still display or develop resistance to these promising drugs. It is possible that cancer stem cells (CSCs) are contributing to this therapeutic resistance. Although CSCs usually represent a small percentage of the total number of cancer cells, they are endowed with the ability of self-renewal and to produce differentiated progeny...
April 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29374392/p53-expression-and-subcellular-survivin-localization-improve-the-diagnosis-and-prognosis-of-patients-with-diffuse-astrocytic-tumors
#11
Roberta Soares Faccion, Paula Sabbo Bernardo, Giselle Pinto Faria de Lopes, Leonardo Soares Bastos, Cristina Lordello Teixeira, José Antonio de Oliveira, Priscila Valverde Fernandes, Luiz Gustavo Dubois, Leila Chimelli, Raquel Ciuvalschi Maia
PURPOSE: Diffuse astrocytic tumors are the most frequently occurring primary central nervous system (CNS) tumors. Their histological sub-classification into diffuse astrocytoma (DA), anaplastic astrocytoma (AA) and glioblastoma (GB) is challenging and the available prognostic factors are limited to age and tumor subtype. Biomarkers that may improve the histological sub-classification and/or serve as prognostic factors are, therefore, urgently needed. The relationship between survivin and p53 in diffuse astrocytic tumor progression and survival is currently unclear...
April 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29260509/synergistic-anticancer-effect-of-panobinostat-and-topoisomerase-inhibitors-through-ros-generation-and-intrinsic-apoptotic-pathway-induction-in-cervical-cancer-cells
#12
Lubna Wasim, Madhu Chopra
PURPOSE: Various combinations of drugs may be effective in the treatment of different types of cancer. Previously, we have shown that combinations of the histone deacetylase inhibitor panobinostat and the topoisomerase inhibitors topotecan or etoposide act synergistically, but the underlying mode of action has remained unknown. Here, we aimed at uncovering the mechanisms underlying this synergism. METHODS: The effects of (combinations of) panobinostat and topotecan or etoposide on cervical cancer-derived HeLa and SiHa cells were assessed using morphological evaluations, scratch wound healing assays, cell cycle analyses, AO/EB staining assays, Annexin V/PI staining assays, reactive oxygen species (ROS) and mitochondrial membrane potential measurements and Western blotting...
April 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29470830/strong-enhancement-by-igf1-r-antagonists-of-hepatocellular-carcinoma-cell-migration-inhibition-by-sorafenib-and-or-vitamin-k1
#13
Rosalba D'Alessandro, Maria Grazia Refolo, Catia Lippolis, Nicola Carella, Caterina Messa, Aldo Cavallini, Brian Irving Carr
PURPOSE: Emerging evidence indicates that combining Sorafenib with vitamin K1 (VK1) may result in a synergistic inhibition of hepatocellular carcinoma (HCC) cell migration and proliferation. Despite this synergy, its benefits may be limited due to drug resistance resulting from cross-talk with the tumor microenvironment. Insulin-like growth factor-1 (IGF1) signaling acts as an important modulator of HCC cell growth, motility and drug resistance. Therefore, we aimed to explore the effects of Sorafenib in combination with VK1 and/or IGF1-R antagonists on HCC cells...
February 22, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29218545/a2b-adenosine-receptor-agonist-induces-cell-cycle-arrest-and-apoptosis-in-breast-cancer-stem-cells-via-erk1-2-phosphorylation
#14
Seyyed Mehdi Jafari, Hamid Reza Joshaghani, Mojtaba Panjehpour, Mahmoud Aghaei
PURPOSE: It has been reported that cancer stem cells (CSCs) may play a crucial role in the development, recurrence and metastasis of breast cancer. Targeting signaling pathways in CSCs is considered to be a promising strategy for the treatment of cancer. Here, we investigated the role of the A2B adenosine receptor (A2BAR) and its associated signaling pathways in governing the proliferation and viability of breast cancer cell line derived CSCs. METHODS: CSCs were isolated from the breast cancer cell lines MCF-7 and MDA-MB-231 using a mammosphere assay...
February 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29168159/lox-1-is-a-poor-prognostic-indicator-and-induces-epithelial-mesenchymal-transition-and-metastasis-in-pancreatic-cancer-patients
#15
Jie Zhang, Lei Zhang, Can Li, Caiting Yang, Lili Li, Shushu Song, Hao Wu, Fenglin Liu, Lan Wang, Jianxin Gu
PURPOSE: Pancreatic cancer (PC) is an aggressive type of cancer that exhibits a rapid progression. Previously LOX-1, which is a type II trans-membrane glycoprotein that is expressed in endothelial cells, has been found to be involved in the development of several types of cancer. As yet, however, the expression of LOX-1 and its functional consequences in PC have not been documented. The present study was aimed at investigating the prognostic relevance of LOX-1 expression in PC patients and at resolving its role in PC metastasis...
February 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29134467/diterpenoid-natural-compound-c4-crassin-exerts-cytostatic-effects-on-triple-negative-breast-cancer-cells-via-a-pathway-involving-reactive-oxygen-species
#16
Cathy E Richards, Sri H Vellanki, Yvonne E Smith, Ann M Hopkins
PURPOSE: Triple-negative breast cancers (TNBC) lack expression of three common cell surface receptors, i.e., estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). Accordingly, TNBCs are associated with fewer treatment options and a relatively poor prognosis. Having screened a National Cancer Institute natural compound library, the purpose of this study was to investigate the bioactivity of compound C4 (Crassin) in TNBC cells. METHODS: Cell viability assays were performed in two TNBC cell lines, MDA-MB-231 and 4T1, following C4 treatment in the presence or absence of the antioxidant N-acetyl-L-cysteine (NAC)...
February 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29134466/glycogen-synthase-kinase-3%C3%AE-mediated-regulation-of-matrix-metalloproteinase-9-and-its-involvement-in-oral-squamous-cell-carcinoma-progression-and-invasion
#17
Kamdeo K Pramanik, Siddavaram Nagini, Abhay K Singh, Prajna Mishra, Tanushree Kashyap, Nidhi Nath, Manzar Alam, Ajay Rana, Rajakishore Mishra
PURPOSE: Oral squamous cell carcinoma (OSCC)-related deaths mainly result from invasion of the tumor cells into local cervical lymph nodes. It has been reported that progressive basement membrane loss promotes the metastatic and invasive capacities of OSCCs. Matrix metalloproteinase-9 (MMP-9) is known to play a central role in tumor progression and invasion. However, the role of MMP-9 in OSCC invasion has so far remained paradoxical and little is known about its regulation. Here, we aimed to assess MMP-9 expression regulation and its activation by glycogen synthase kinase-3β during human OSCC progression and invasion...
February 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29119387/a-new-etv6-ntrk3-cell-line-model-reveals-malat1-as-a-novel-therapeutic-target-a-short-report
#18
Suning Chen, Stefan Nagel, Bjoern Schneider, Haiping Dai, Robert Geffers, Maren Kaufmann, Corinna Meyer, Claudia Pommerenke, Kenneth S Thress, Jiao Li, Hilmar Quentmeier, Hans G Drexler, Roderick A F MacLeod
BACKGROUND: Previously, the chromosomal translocation t(12;15)(p13;q25) has been found to recurrently occur in both solid tumors and leukemias. This translocation leads to ETV6-NTRK3 (EN) gene fusions resulting in ectopic expression of the NTRK3 neurotropic tyrosine receptor kinase moiety as well as oligomerization through the donated ETV6-sterile alpha motif domain. As yet, no in vitro cell line model carrying this anomaly is available. Here we genetically characterized the acute promyelocytic leukemia (APL) cell line AP-1060 and, by doing so, revealed the presence of a t(12;15)(p13;q25)...
February 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29076027/serum-exosomal-mir-301a-as-a-potential-diagnostic-and-prognostic-biomarker-for-human-glioma
#19
Fengming Lan, Qin Qing, Qiang Pan, Man Hu, Huiming Yu, Xiao Yue
PURPOSE: Exosomal miRNAs that play an important role in cell-cell communication have attracted major attention as potential diagnostic and prognostic biomarkers for various cancers. The aim of this study was to determine the diagnostic/prognostic significance of serum exosomal miR-301a in glioma patients. METHODS: Quantitative real-time PCR was used to determine the serum exosomal expression levels of miR-301a. Kaplan-Meier survival analyses, Cox regression analyses and ROC working curve analyses were applied to assess the diagnostic and prognostic values of miR-301a in glioma patients...
February 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29039135/metabolic-iodine-and-tumours
#20
D S Robertson
PURPOSE: Purpose of the work is to highlight a possible connection between metabolic iodine and natural tumour control. METHOD: Method adopted is to use information available in the literature. RESULT: Result indicated a means of the purpose being attained. CONCLUSION: Conclusion drawn is that a tumour control method derives from the relationship studied.
February 2018: Cellular Oncology (Dordrecht)
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