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Journal of Cachexia, Sarcopenia and Muscle

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https://www.readbyqxmd.com/read/29774990/searching-for-a-mitochondrial-root-to-the-decline-in-muscle-function-with-ageing
#1
EDITORIAL
Marta Gonzalez-Freire, Fatemeh Adelnia, Ruin Moaddel, Luigi Ferrucci
Sarcopenia, the age-related loss of muscle mass and strength, is linked to a range of adverse outcomes, such as impaired physical performance, cognitive function, and mortality. Preventing sarcopenia may reduce the burden of functional decline with aging and its impact on physiological and economic well-being in older adults. Mitochondria in muscle cells lose their intrinsic efficiency and capacity to produce energy during aging, and it has been hypothesized that such a decline is the main driver of sarcopenia...
May 18, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29766660/the-deterioration-of-muscle-mass-and-radiodensity-is-prognostic-of-poor-survival-in-stage-i-iii-colorectal-cancer-a-population-based-cohort-study-c-scans
#2
Justin C Brown, Bette J Caan, Jeffrey A Meyerhardt, Erin Weltzien, Jingjie Xiao, Elizabeth M Cespedes Feliciano, Candyce H Kroenke, Adrienne Castillo, Marilyn L Kwan, Carla M Prado
BACKGROUND: Muscle abnormalities such as low muscle mass and low muscle radiodensity are well known risk factors for unfavourable cancer prognosis. However, little is known in regard to the degree and impact of longitudinal changes in muscle mass and radiodensity within the context of cancer. Here, we explore the relationship between muscle wasting and mortality in a large population-based study of patients with non-metastatic colorectal cancer (CRC). METHODS: A total of 1924 patients with stage I-III CRC who underwent surgical resection in the Kaiser Permanente Northern California Health System were included...
May 15, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29761654/low-load-resistance-exercise-during-inactivity-is-associated-with-greater-fibre-area-and-satellite-cell-expression-in-older-skeletal-muscle
#3
Daniel R Moore, Ryan P Kelly, Michaela C Devries, Tyler A Churchward-Venne, Stuart M Phillips, Gianni Parise, Adam P Johnston
BACKGROUND: Age-related sarcopenia is accelerated by physical inactivity. Low-load resistance exercise (LLRE) counters inactivity-induced muscle atrophy in older adults, but changes in muscle fibre morphology are unstudied. We aimed to determine the impact of LLRE during short-term inactivity (step-reduction) on muscle fibre size and capillarity as well as satellite cell (SC) content in older skeletal muscle. METHODS: Fourteen older (~71 years) male adults underwent 14 days of step reduction (<1500 steps/day) while performing six sessions of LLRE (~30% maximal strength) with one leg (SR + EX) while the contralateral leg served as an untrained control (SR)...
May 14, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29722201/treating-cachexia-using-soluble-acvr2b-improves-survival-alters-mtor-localization-and-attenuates-liver-and-spleen-responses
#4
Tuuli A Nissinen, Jaakko Hentilä, Fabio Penna, Anita Lampinen, Juulia H Lautaoja, Vasco Fachada, Tanja Holopainen, Olli Ritvos, Riikka Kivelä, Juha J Hulmi
BACKGROUND: Cancer cachexia increases morbidity and mortality, and blocking of activin receptor ligands has improved survival in experimental cancer. However, the underlying mechanisms have not yet been fully uncovered. METHODS: The effects of blocking activin receptor type 2 (ACVR2) ligands on both muscle and non-muscle tissues were investigated in a preclinical model of cancer cachexia using a recombinant soluble ACVR2B (sACVR2B-Fc). Treatment with sACVR2B-Fc was applied either only before the tumour formation or with continued treatment both before and after tumour formation...
May 2, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29675984/associations-of-pre-existing-co-morbidities-with-skeletal-muscle-mass-and-radiodensity-in-patients-with-non-metastatic-colorectal-cancer
#5
Jingjie Xiao, Bette J Caan, Erin Weltzien, Elizabeth M Cespedes Feliciano, Candyce H Kroenke, Jeffrey A Meyerhardt, Vickie E Baracos, Marilyn L Kwan, Adrienne L Castillo, Carla M Prado
BACKGROUND AND AIM: Co-morbidities and computerized tomography-measured muscle abnormalities are both common in cancer patients and independently adversely influence clinical outcomes. Muscle abnormalities are also evident in other diseases, such as diabetes and obesity. This study examined for the first time the association between co-morbidities and muscle abnormalities in patients diagnosed with colorectal cancer (CRC). METHODS: This cross-sectional study included 3051 non-metastatic patients with Stages I-III CRC...
April 19, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29682908/tracking-disease-progression-non-invasively-in-duchenne-and-becker-muscular-dystrophies
#6
Pietro Spitali, Kristina Hettne, Roula Tsonaka, Mohammed Charrout, Janneke van den Bergen, Zaïda Koeks, Hermien E Kan, Melissa T Hooijmans, Andreas Roos, Volker Straub, Francesco Muntoni, Cristina Al-Khalili-Szigyarto, Marleen J A Koel-Simmelink, Charlotte E Teunissen, Hanns Lochmüller, Erik H Niks, Annemieke Aartsma-Rus
BACKGROUND: Analysis of muscle biopsies allowed to characterize the pathophysiological changes of Duchenne and Becker muscular dystrophies (D/BMD) leading to the clinical phenotype. Muscle tissue is often investigated during interventional dose finding studies to show in situ proof of concept and pharmacodynamics effect of the tested drug. Less invasive readouts are needed to objectively monitor patients' health status, muscle quality, and response to treatment. The identification of serum biomarkers correlating with clinical function and able to anticipate functional scales is particularly needed for personalized patient management and to support drug development programs...
April 16, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29663711/dilution-of-oral-d-3-creatine-to-measure-creatine-pool-size-and-estimate-skeletal-muscle-mass-development-of-a-correction-algorithm
#7
Mahalakshmi Shankaran, Gregg Czerwieniec, Chancy Fessler, Po-Yin Anne Wong, Salena Killion, Scott M Turner, Marc K Hellerstein, William J Evans
BACKGROUND: Muscle mass can be measured directly in vivo by isotope dilution, using Creatine-(methyl-d3 ) monohydrate (D3 -Cr) by mouth followed by measurement of the steady-state enrichment of D3 -creatinine (D3 -Crn) in urine. Isotope dilution methods require knowledge of the amount of tracer delivered to the pool of interest. In a subset of human subjects, a small amount of orally administered D3 -Cr 'spills' into urine after absorption and prior to transport into skeletal muscle cells...
April 16, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29654645/a-randomized-trial-of-adjunct-testosterone-for-cancer-related-muscle-loss-in-men-and-women
#8
Traver J Wright, E Lichar Dillon, William J Durham, Albert Chamberlain, Kathleen M Randolph, Christopher Danesi, Astrid M Horstman, Charles R Gilkison, Maurice Willis, Gwyn Richardson, Sandra S Hatch, Daniel C Jupiter, Susan McCammon, Randall J Urban, Melinda Sheffield-Moore
BACKGROUND: Cancer cachexia negatively impacts cancer-related treatment options, quality of life, morbidity, and mortality, yet no established therapies exist. We investigated the anabolic properties of testosterone to limit the loss of body mass in late stage cancer patients undergoing standard of care cancer treatment. METHODS: A randomized, double-blind, placebo-controlled phase II clinical trial was undertaken to assess the potential therapeutic role of adjunct testosterone to limit loss of body mass in patients with squamous cell carcinoma of the cervix or head and neck undergoing standard of care treatment including chemotherapy and chemoradiation...
April 14, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29654636/healthy-community-living-older-men-differ-from-women-in-associations-between-myostatin-levels-and-skeletal-muscle-mass
#9
Li-Ning Peng, Wei-Ju Lee, Li-Kuo Liu, Ming-Hsien Lin, Liang-Kung Chen
BACKGROUND: Myostatin is a negative regulator of muscle growth but the relationship between serum myostatin levels and muscle mass is unclear. This study investigated the association between serum myostatin levels and skeletal muscle mass among healthy older community residents in Taiwan, to evaluate the potential of serum myostatin as a biomarker for diagnosing sarcopenia and/or evaluating the effect of its treatment. METHODS: Study data were excerpted from a random subsample of the I-Lan Longitudinal Aging Study population...
April 13, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29608040/muscle-restricted-nuclear-receptor-interaction-protein-knockout-causes-motor-neuron-degeneration-through-down-regulation-of-myogenin-at-the-neuromuscular-junction
#10
Hsin-Hsiung Chen, Li-Kai Tsai, Kuan-Yu Liao, Tung-Chien Wu, Yun-Hsin Huang, Yuan-Chun Huang, Szu-Wei Chang, Pei-Yu Wang, Yeou-Ping Tsao, Show-Li Chen
BACKGROUND: Nuclear receptor interaction protein (NRIP) is a calcium/calmodulin (CaM) binding protein. Nuclear receptor interaction protein interacts with CaM to activate calcineurin and CaMKII signalling. The conventional NRIP knockout mice (global knockout) showed muscular abnormality with reduction of muscle oxidative functions and motor function defects. METHODS: To investigate the role of NRIP on neuromuscular system, we generated muscle-restricted NRIP knockout mice [conditional knockout (cKO)]...
April 2, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29582584/dysregulation-of-metabolic-associated-pathways-in-muscle-of-breast-cancer-patients-preclinical-evaluation-of-interleukin-15-targeting-fatigue
#11
Joseph Bohlen, Sarah L McLaughlin, Hannah Hazard-Jenkins, Aniello M Infante, Cortney Montgomery, Mary Davis, Emidio E Pistilli
BACKGROUND: Breast cancer patients report a perception of increased muscle fatigue, which can persist following surgery and standardized therapies. In a clinical experiment, we tested the hypothesis that pathways regulating skeletal muscle fatigue are down-regulated in skeletal muscle of breast cancer patients and that different muscle gene expression patterns exist between breast tumour subtypes. In a preclinical study, we tested the hypothesis that mammary tumour growth in mice induces skeletal muscle fatigue and that overexpression of the cytokine interleukin-15 (IL-15) can attenuate mammary tumour-induced muscle fatigue...
March 26, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29582582/mirna-23a-27a-attenuates-muscle-atrophy-and-renal-fibrosis-through-muscle-kidney-crosstalk
#12
Aiqing Zhang, Min Li, Bin Wang, Janet D Klein, S Russ Price, Xiaonan H Wang
BACKGROUND: The treatment of muscle wasting is accompanied by benefits in other organs, possibly resulting from muscle-organ crosstalk. However, how the muscle communicates with these organs is less understood. Two microRNAs (miRs), miR-23a and miR-27a, are located together in a gene cluster and regulate proteins that are involved in the atrophy process. MiR-23a/27a has been shown to reduce muscle wasting and act as an anti-fibrotic agent. We hypothesized that intramuscular injection of miR-23a/27a would counteract both muscle wasting and renal fibrosis lesions in a streptozotocin-induced diabetic model...
March 26, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29575818/collagen-induced-arthritis-as-an-animal-model-of-rheumatoid-cachexia
#13
Paulo V G Alabarse, Priscila S Lora, Jordana M S Silva, Rafaela C E Santo, Eduarda C Freitas, Mayara S de Oliveira, Andrelise S Almeida, Mônica Immig, Vivian O N Teixeira, Lidiane I Filippin, Ricardo M Xavier
BACKGROUND: Rheumatoid arthritis is characterized by chronic polyarticular synovitis and presents systemic changes that impact quality of life, such as impaired muscle function, seen in up to 66% of the patients. This can progress to severely debilitating state known as rheumatoid cachexia-without loss of fat mass and body weight-for which there is little consensus in terms of diagnosis or treatment. This study aims to evaluate whether the collagen-induced arthritis (CIA) animal model also develops clinical and functional features characteristic of rheumatoid cachexia...
March 25, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29575771/the-habenula-as-a-novel-link-between-the-homeostatic-and-hedonic-pathways-in-cancer-associated-weight-loss-a-pilot-study
#14
Maria Maldonado, David L Molfese, Humsini Viswanath, Kaylah Curtis, Ashley Jones, Teresa G Hayes, Marco Marcelli, Sanjay Mediwala, Philip Baldwin, Jose M Garcia, Ramiro Salas
BACKGROUND: Little is known about the brain mechanisms underlying cancer-associated weight loss (C-WL) in humans despite this condition negatively affecting their quality of life and survival. We tested the hypothesis that patients with C-WL have abnormal connectivity in homeostatic and hedonic brain pathways together with altered brain activity during food reward. METHODS: In 12 patients with cancer and 12 healthy controls, resting-state functional connectivity (RSFC, resting brain activity observed through changes in blood flow in the brain which creates a blood oxygen level-dependent signal that can be measured using functional magnetic resonance imaging) was used to compare three brain regions hypothesized to play a role in C-WL: the hypothalamus (homeostatic), the nucleus accumbens (hedonic), and the habenula (an important regulator of reward)...
March 25, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29573220/depleted-iron-stores-are-associated-with-inspiratory-muscle-weakness-independently-of-skeletal-muscle-mass-in-men-with-systolic-chronic-heart-failure
#15
Michał Tkaczyszyn, Marcin Drozd, Kinga Węgrzynowska-Teodorczyk, Irena Flinta, Kamil Kobak, Waldemar Banasiak, Piotr Ponikowski, Ewa A Jankowska
BACKGROUND: Skeletal and respiratory muscle dysfunction constitutes an important pathophysiological feature of heart failure (HF). We assessed the relationships between respiratory muscle function, skeletal muscle mass, and physical fitness in men with HF with reduced left ventricular ejection fraction (HFrEF), and investigated the hypothesis of whether iron deficiency (ID) contributes to respiratory muscle dysfunction in these patients. METHODS: We examined 53 male outpatients with stable HFrEF without asthma or chronic obstructive pulmonary disease (age: 64 ± 10 years; New York Heart Association [NYHA] class I/II/III: 36/51/13%; ischaemic aetiology: 83%; all with left ventricular ejection fraction ≤40%) and 10 middle-aged healthy men (control group)...
March 23, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29570952/response-to-the-use-of-ultrasound-for-the-estimation-of-muscle-mass-one-site-fits-most
#16
LETTER
Willemke Nijholt, Harriët Jager-Wittenaar, Aldo Scafoglieri, Johannes S M Hobbelen, Cees van der Schans
No abstract text is available yet for this article.
March 23, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29569834/knee-extension-rate-of-torque-development-and-peak-torque-associations-with-lower-extremity-function
#17
Yusuke Osawa, Stephanie A Studenski, Luigi Ferrucci
BACKGROUND: With aging, the ability to generate muscle force decreases, contributing to declines in physical functions such as walking. While most studies assess muscle force by peak torque, the rate of torque development (RTD) reflects a dynamic component of muscle performance that is important for physical function. Using data from the Baltimore Longitudinal Study of Aging, we assessed whether RTD adds significantly to peak torque in associations with lower extremity performance. If so, RTD may help identify weak older adults for screening and intervention...
March 23, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29542875/muscular-responses-to-testosterone-replacement-vary-by-administration-route-a-systematic-review-and-meta-analysis
#18
Jared W Skinner, Dana M Otzel, Andrew Bowser, Daniel Nargi, Sanjay Agarwal, Mark D Peterson, Baiming Zou, Stephen E Borst, Joshua F Yarrow
BACKGROUND: Inconsistent fat-free mass (FFM) and muscle strength responses have been reported in randomized clinical trials (RCTs) administering testosterone replacement therapy (TRT) to middle-aged and older men. Our objective was to conduct a meta-analysis to determine whether TRT improves FFM and muscle strength in middle-aged and older men and whether the muscular responses vary by TRT administration route. METHODS: Systematic literature searches of MEDLINE/PubMed and the Cochrane Library were conducted from inception through 31 March 2017 to identify double-blind RCTs that compared intramuscular or transdermal TRT vs...
March 15, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29542279/megestrol-acetate-for-cachexia-anorexia-syndrome-a-systematic-review
#19
REVIEW
Vicente Ruiz-García, Eduardo López-Briz, Rafael Carbonell-Sanchis, Sylvia Bort-Martí, José Luis Gonzálvez-Perales
In 1993, megestrol acetate (MA) was approved by the US Food and Drug Administration for the treatment of anorexia, cachexia, or unexplained weight loss in patients with acquired immunodeficiency syndrome. The mechanism by which MA increases appetite is unknown, and its effectiveness for anorexia and cachexia in neoplastic, elderly, and acquired immunodeficiency syndrome patients is under investigation. This is an updated version of a Cochrane systematic review first published in 2005 and later updated in 2013 entitled 'Megestrol acetate for the treatment of anorexia-cachexia syndrome'...
March 14, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29512357/a-newly-identified-lncrna-mar1-acts-as-a-mir-487b-sponge-to-promote-skeletal-muscle-differentiation-and-regeneration
#20
Zong-Kang Zhang, Jie Li, Daogang Guan, Chao Liang, Zhenjian Zhuo, Jin Liu, Aiping Lu, Ge Zhang, Bao-Ting Zhang
BACKGROUND: Skeletal muscle atrophy induced by either aging (sarcopenia) or mechanical unloading is associated with serious health consequences. Long non-coding RNAs (lncRNAs) are implicated as important regulators in numerous physiological and pathological processes. METHODS: Microarray analysis was performed to identify the differentially expressed lncRNAs in skeletal muscle between adult and aged mice. The most decreased lncRNA in aged skeletal muscle was identified...
March 7, 2018: Journal of Cachexia, Sarcopenia and Muscle
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