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https://www.readbyqxmd.com/read/28808040/evaluating-the-longitudinal-risk-of-social-vigilance-on-atherosclerosis-study-protocol-for-the-north-texas-heart-study
#1
John M Ruiz, Daniel J Taylor, Bert N Uchino, Timothy W Smith, Matthew Allison, Chul Ahn, Jillian J Johnson, Joshua M Smyth
INTRODUCTION: Psychosocial factors are increasingly recognised as important determinants of cardiovascular disease risk. The North Texas Heart Study aims to understand the mechanisms responsible for this association with a focus on social vigilance (ie, scanning the environment for social threats). There is also growing interest in supplementing traditional methods (eg, survey assessment of psychosocial risk paired with cross-sectional and longitudinal health outcomes) with daily or repeated momentary assessment of psychosocial factors...
August 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801447/correction-screening-for-cancer-in-patients-with-unprovoked-venous-thromboembolism-protocol-for-a-systematic-review-and-individual-patient-data-meta-analysis
#2
LETTER
(no author information available yet)
No abstract text is available yet for this article.
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801446/correction-european-prospective-cohort-study-on-enterobacteriaceae-showing-resistance-to-carbapenems-eureca-a-protocol-of-a-european-multicentre-observational-study
#3
LETTER
(no author information available yet)
No abstract text is available yet for this article.
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801445/correction-efficacy-and-safety-of-gelatine-tannate-for-the-treatment-of-acute-gastroenteritis-in-children-protocol-of-a-randomised-controlled-trial
#4
LETTER
(no author information available yet)
No abstract text is available yet for this article.
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801444/radical-cystectomy-bladder-removal-against-intravesical-bcg-immunotherapy-for-high-risk-non-muscle-invasive-bladder-cancer-bravo-a-protocol-for-a-randomised-controlled-feasibility-study
#5
Jamie B Oughton, Heather Poad, Maureen Twiddy, Michelle Collinson, Victoria Hiley, Kathryn Gordon, Mark Johnson, Sunjay Jain, Aidan P Noon, Rohit Chahal, Matt Simms, Mohantha Dooldeniya, Phillip Koenig, Louise Goodwin, Julia M Brown, James W F Catto
INTRODUCTION: High-risk non-muscle invasive bladder cancer (HRNMIBC) is a heterogeneous disease that can be difficult to predict. While around 25% of cancers progress to invasion and metastases, the remaining majority of tumours remain within the bladder. It is uncertain whether patients with HRNMIBC are better treated with intravesical maintenance BCG (mBCG) immunotherapy or primary radical cystectomy (RC). A definitive randomised controlled trial (RCT) is needed to compare these two different treatments but may be difficult to recruit to and has not been attempted to date...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801443/the-provision-of-medical-assistance-in-dying-protocol-for-a-scoping-review
#6
Simon J W Oczkowski, Ian Ball, Carol Saleh, Gaelen Kalles, Anatoli Chkaroubo, Mike Kekewich, Paul Miller, Marianne Dees, Andrea Frolic
INTRODUCTION: Medical assistance in dying (MAID), a term encompassing both euthanasia and assisted suicide, was decriminalised in Canada in 2015. Although Bill C-14 legislated eligibility criteria under which patients could receive MAID, it did not provide guidance regarding the technical aspects of providing an assisted death. Therefore, we propose a scoping review to map the characteristics of the existing medical literature describing the medications, settings, participants and outcomes of MAID, in order to identify knowledge gaps and areas for future research...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801442/bangladesh-environmental-enteric-dysfunction-beed-study-protocol-for-a-community-based-intervention-study-to-validate-non-invasive-biomarkers-of-environmental-enteric-dysfunction
#7
Mustafa Mahfuz, Subhasish Das, Ramendra Nath Mazumder, M Masudur Rahman, Rashidul Haque, Md Muzibur Rahman Bhuiyan, Hasina Akhter, Md Shafiqul Alam Sarker, Dinesh Mondal, Syed Shafi Ahmed Muaz, A S M Bazlul Karim, Stephen M Borowitz, Christopher A Moskaluk, Michael J Barratt, William A Petri, Jeffrey I Gordon, Tahmeed Ahmed
INTRODUCTION: Environmental enteric dysfunction (EED) is a subacute inflammatory condition of the small intestinal mucosa with unclear aetiology that may account for more than 40% of all cases of stunting. Currently, there are no universally accepted protocols for the diagnosis, treatment and ultimately prevention of EED. The Bangladesh Environmental Enteric Dysfunction (BEED) study is designed to validate non-invasive biomarkers of EED with small intestinal biopsy, better understand disease pathogenesis and identify potential therapeutic targets for interventions designed to control EED and stunting...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801441/changes-in-prevalence-of-workplace-violence-against-doctors-in-all-medical-specialties-in-norway-between-1993-and-2014-a-repeated-cross-sectional-survey
#8
Ingrid Hjulstad Johansen, Valborg Baste, Judith Rosta, Olaf G Aasland, Tone Morken
OBJECTIVES: The aim of this study was to investigate whether reported prevalence of experienced threats, real acts of violence and debilitating fear of violence among Norwegian doctors have increased over the last two decades. DESIGN: Repeated cross-sectional survey. SETTING: All healthcare levels and medical specialties in Norway. PARTICIPANTS: Representative samples of Norwegian doctors in 1993 (n=2628) and 2014 (n=1158)...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801440/baseline-data-from-a-planned-rct-on-attitudes-to-female-genital-cutting-after-migration-when-are-interventions-justified
#9
Anna Wahlberg, Sara Johnsdotter, Katarina Ekholm Selling, Carina Källestål, Birgitta Essén
OBJECTIVES: To present the primary outcomes from a baseline study on attitudes towards female genital cutting (FGC) after migration. DESIGN: Baseline data from a planned cluster randomised, controlled trial. Face-to-face interviews were used to collect questionnaire data in 2015. Based on our hypothesis that established Somalis could be used as facilitators of change among those newly arrived, data were stratified into years of residency in Sweden. SETTING: Sweden...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801439/validation-of-asthma-recording-in-the-clinical-practice-research-datalink-cprd
#10
Francis Nissen, Daniel R Morales, Hana Mullerova, Liam Smeeth, Ian J Douglas, Jennifer K Quint
OBJECTIVES: The optimal method of identifying people with asthma from electronic health records in primary care is not known. The aim of this study is to determine the positive predictive value (PPV) of different algorithms using clinical codes and prescription data to identify people with asthma in the United Kingdom Clinical Practice Research Datalink (CPRD). METHODS: 684 participants registered with a general practitioner (GP) practice contributing to CPRD between 1 December 2013 and 30 November 2015 were selected according to one of eight predefined potential asthma identification algorithms...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801438/associations-between-polypharmacy-and-treatment-intensity-for-hypertension-and-diabetes-a-cross-sectional-study-of-nursing-home-patients-in-british-columbia-canada
#11
Rita McCracken, James McCormack, Margaret J McGregor, Sabrina T Wong, Scott Garrison
OBJECTIVES: Describe nursing home polypharmacy prevalence in the context of prescribing for diabetes and hypertension and determine possible associations between lower surrogate markers for treated hypertension and diabetes (overtreatment) and polypharmacy. DESIGN: Cross-sectional study. SETTING: 6 nursing homes in British Columbia, Canada. PARTICIPANTS: 214 patients residing in one of the selected facilities during data collection period...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801437/patient-experience-of-nhs-health-checks-a-systematic-review-and-qualitative-synthesis
#12
Juliet A Usher-Smith, Emma Harte, Calum MacLure, Adam Martin, Catherine L Saunders, Catherine Meads, Fiona M Walter, Simon J Griffin, Jonathan Mant
OBJECTIVE: To review the experiences of patients attending NHS Health Checks in England. DESIGN: A systematic review of quantitative and qualitative studies with a thematic synthesis of qualitative studies. DATA SOURCES: An electronic literature search of Medline, Embase, Health Management Information Consortium, Cumulative Index of Nursing and Allied Health Literature, Global Health, PsycInfo, Web of Science, OpenGrey, the Cochrane Library, National Health Service (NHS) Evidence, Google Scholar, Google, Clinical Trials...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801436/effect-of-endoscopic-transpapillary-biliary-drainage-with-without-endoscopic-sphincterotomy-on-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-in-patients-with-biliary-stricture-e-best-a-protocol-for-a-multicentre-randomised-controlled-trial
#13
Shin Kato, Masaki Kuwatani, Ryo Sugiura, Itsuki Sano, Kazumichi Kawakubo, Kota Ono, Naoya Sakamoto
INTRODUCTION: The effect of endoscopic sphincterotomy prior to endoscopic biliary stenting to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis remains to be fully elucidated. The aim of this study is to prospectively evaluate the non-inferiority of non-endoscopic sphincterotomy prior to stenting for naïve major duodenal papilla compared with endoscopic sphincterotomy prior to stenting in patients with biliary stricture. METHODS AND ANALYSIS: We designed a multicentre randomised controlled trial, for which we will recruit 370 patients with biliary stricture requiring endoscopic biliary stenting from 26 high-volume institutions in Japan...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801435/differences-in-the-pregnancy-gestation-period-and-mean-birth-weights-in-infants-born-to-indian-pakistani-bangladeshi-and-white-british-mothers-in-luton-uk-a-retrospective-analysis-of-routinely-collected-data
#14
Rebecca Garcia, Nasreen Ali, Andy Guppy, Malcolm Griffiths, Gurch Randhawa
OBJECTIVE: To compare mean birth weights and gestational age at delivery of infants born to Indian, Pakistani, Bangladeshi and white British mothers in Luton, UK. DESIGN: Retrospective analysis using routinely recorded secondary data in Ciconia Maternity information System, between 2008 and 2013. SETTING: Luton, UK. PARTICIPANTS: Mothers whose ethnicity was recorded as white British, Bangladeshi, Pakistani or Indian and living in Luton, aged over 16, who had a live singleton birth over 24 weeks of gestation were included in the analysis (n=14 871)...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801434/comparative-effectiveness-of-six-chinese-herb-formulas-for-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-protocol-for-systematic-review-and-network-meta-analysis
#15
Shaonan Liu, Jing Chen, Yihan He, Lei Wu, Jiaqi Lai, Jinhong Zuo, Lihong Yang, Xinfeng Guo
INTRODUCTION: Chinese medicine is commonly used to combine with pharmacotherapy for the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Six Chinese herb formulas involving Weijing decoction, Maxingshigan decoction, Yuebijiabanxia decoction, Qingqihuatan decoction, Dingchuan decoction and Sangbaipi decoction are recommended in Chinese medicine clinical guideline or textbook, to relieve patients with phlegm-heat according to Chinese syndrome differentiation...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801433/developing-core-economic-outcome-sets-for-asthma-studies-a-protocol-for-a-systematic-review
#16
Natalia Hounsome, Deborah Fitzsimmons, Ceri Phillips, Anita Patel
INTRODUCTION: Core outcome sets are standardised lists of outcomes, which should be measured and reported in all clinical studies of a specific condition. This study aims to develop core outcome sets for economic evaluations in asthma studies. Economic outcomes include items such as costs, resource use or quality-adjusted life years. The starting point in developing core outcome sets will be conducting a systematic literature review to establish a preliminary list of reporting items to be considered for inclusion in the core outcome set...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801432/psychiatric-disorders-among-people-with-cancer-in-low-and-lower-middle-income-countries-study-protocol-for-a-systematic-review-and-meta-analysis
#17
Zoe J Walker, Michael P Jones, Arun V Ravindran
INTRODUCTION: Cancer is a rapidly growing public health problem in low- and lower-middle-income countries (LLMICs). There is evidence from upper-income countries that comorbid mental illness is common and can adversely impact cancer outcomes. Little is known about this burden in LLMICs. This systematic review has two aims. The first is to review the prevalence and patterns of psychiatric comorbidity in adults with cancer in LLMICs. The second is to review psychiatric treatment outcomes in this population...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801431/socioeconomic-and-geographical-variation-in-general-practitioner-consultations-for-allergic-rhinitis-in-england-2003-2014-an-observational-study
#18
Daniel Todkill, Paul Loveridge, Alex James Elliot, Roger Morbey, Simon de Lusignan, Obaghe Edeghere, Gillian Smith
OBJECTIVE: Allergic rhinitis (AR) is a global health problem, potentially impacting individuals' sleep, work and social life. We aimed to use a surveillance network of general practitioners (GPs) to describe the epidemiology of AR consultations in England. SETTING: A large GP surveillance network covering approximately 53% of the English population. METHODS: GP consultations for AR across England between 30 December 2002 and 31 December 2014 were analysed...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801430/association-between-pregravid-physical-activity-and-family-history-of-stroke-and-risk-of-stillbirth-population-based-cohort-study
#19
Grace M Egeland, Grethe S Tell, Øyvind Næss, Jannicke Igland, Kari Klungsøyr
OBJECTIVES: To evaluate whether family history of disease and pregravid lifestyle and cardiovascular risk factors are associated with subsequent stillbirth delivery. DESIGN: Prepregnancy cohort study. SETTING: Cohort Norway regional health surveys (1994-2003) linked to Medical Birth Registry of Norway for deliveries through 2012. PARTICIPANTS: 13 497 singleton births (> 22 weeks gestation) in 8478 women. MAIN OUTCOME MEASURE: Risk of stillbirth evaluated by Poisson regression...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801429/multicentric-randomised-study-of-helicobacter-pylori-eradication-and-pepsinogen-testing-for-prevention-of-gastric-cancer-mortality-the-gistar-study
#20
Marcis Leja, Jin Young Park, Raul Murillo, Inta Liepniece-Karele, Sergejs Isajevs, Ilze Kikuste, Dace Rudzite, Petra Krike, Sergei Parshutin, Inese Polaka, Arnis Kirsners, Daiga Santare, Valdis Folkmanis, Ilva Daugule, Martyn Plummer, Rolando Herrero
INTRODUCTION: Population-based eradication of Helicobacter pylori has been suggested to be cost-effective and is recommended by international guidelines. However, the potential adverse effects of widespread antibiotic use that this would entail have not been sufficiently studied. An alternative way to decrease gastric cancer mortality is by non-invasive search for precancerous lesions, in particular gastric atrophy; pepsinogen tests are the best currently available alternative. The primary objective of GISTAR is to determine whether H pylori eradication combined with pepsinogen testing reduces mortality from gastric cancer among 40-64-year-old individuals...
August 11, 2017: BMJ Open
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