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https://www.readbyqxmd.com/read/28918415/treatment-options-and-barriers-to-case-management-of-neonatal-pneumonia-in-india-a-protocol-for-a-scoping-review
#1
N Sreekumaran Nair, Leslie Edward Lewis, Shruti Murthy, Myron Anthony Godinho, Theophilus Lakiang, Bhumika T Venkatesh
INTRODUCTION: India contributes to the highest neonatal deaths globally. Case management is said to be the cornerstone of pneumonia control. Much of the published evidence focuses on children aged 1 to 59 months. This scoping review, thus, aims to identify the treatment options for and barriers to case management of neonatal pneumonia in India. METHODS AND ANALYSIS: This protocol is part of a series of three reviews on neonatal pneumonia in India. Studies addressing treatment of or barriers to case management of neonatal pneumonia in Indian context, published in English in peer-reviewed and indexed journals will be eligible for inclusion...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28918414/a-protocol-of-a-cross-sectional-study-evaluating-an-online-tool-for-early-career-peer-reviewers-assessing-reports-of-randomised-controlled-trials
#2
Anthony Chauvin, David Moher, Doug Altman, David L Schriger, Sabina Alam, Sally Hopewell, Daniel R Shanahan, Alessandro Recchioni, Philippe Ravaud, Isabelle Boutron
INTRODUCTION: Systematic reviews evaluating the impact of interventions to improve the quality of peer review for biomedical publications highlighted that interventions were limited and have little impact. This study aims to compare the accuracy of early career peer reviewers who use an innovative online tool to the usual peer reviewer process in evaluating the completeness of reporting and switched primary outcomes in completed reports. METHODS AND ANALYSIS: This is a cross-sectional study of individual two-arm parallel-group randomised controlled trials (RCTs) published in the BioMed Central series medical journals, BMJ, BMJ Open and Annals of Emergency Medicine and indexed with the publication type 'Randomised Controlled Trial'...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28918413/post-traumatic-growth-and-its-relationship-to-quality-of-life-up-to-9-years-after-liver-transplantation-a-cross-sectional-study-in-spain
#3
María Ángeles Pérez-San-Gregorio, Agustín Martín-Rodríguez, Mercedes Borda-Mas, María Luisa Avargues-Navarro, José Pérez-Bernal, Rupert Conrad, Miguel Ángel Gómez-Bravo
OBJECTIVE: Little is known concerning post-traumatic growth (PTG) after liver transplantation. Against this backdrop the current study analysed the relationship between PTG and time since transplantation on quality of life. Furthermore, it compared PTG between liver transplant recipients and their caregivers. DESIGN: Cross-sectional case-control study. SETTING: University Hospital in Spain. PARTICIPANTS: 240 adult liver transplant recipients who had undergone only one transplantation, with no severe mental disease, were the participants of the study...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28918412/prediction-of-early-unplanned-intensive-care-unit-readmission-in-a-uk-tertiary-care-hospital-a-cross-sectional-machine-learning-approach
#4
Thomas Desautels, Ritankar Das, Jacob Calvert, Monica Trivedi, Charlotte Summers, David J Wales, Ari Ercole
OBJECTIVES: Unplanned readmissions to the intensive care unit (ICU) are highly undesirable, increasing variance in care, making resource planning difficult and potentially increasing length of stay and mortality in some settings. Identifying patients who are likely to suffer unplanned ICU readmission could reduce the frequency of this adverse event. SETTING: A single academic, tertiary care hospital in the UK. PARTICIPANTS: A set of 3326 ICU episodes collected between October 2014 and August 2016...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28918411/combining-cd4-recovery-and-cd4-cd8-ratio-restoration-as-an-indicator-for-evaluating-the-outcome-of-continued-antiretroviral-therapy-an-observational-cohort-study
#5
Shui Shan Lee, Ngai Sze Wong, Bonnie Chun Kwan Wong, Ka Hing Wong, Kenny Chi Wai Chan
OBJECTIVES: Immune recovery following highly active antiretroviral therapy (HAART) is commonly assessed by the degree of CD4 reconstitution alone. In this study, we aimed to assess immune recovery by incorporating both CD4 count and CD4:CD8 ratio. DESIGN: Observational cohort study SETTING AND PARTICIPANTS: Clinical data from Chinese HIV-positive patients attending the largest HIV service in Hong Kong and who had been on HAART for ≥4 years were accessed. MAIN OUTCOME MEASURES: Optimal immune outcome was defined as a combination of a CD4 count ≥500/μL and a CD4:CD8 ratio ≥0...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28918410/-just-like-a-normal-pain-what-do-people-with-diabetes-mellitus-experience-when-having-a-myocardial-infarction-a-qualitative-study-recruited-from-uk-hospitals
#6
Nikita Berman, Melvyn Mark Jones, Daan A De Coster
OBJECTIVE: The objective of the study was to investigate the symptoms people with diabetes experience when having a myocardial infarction (MI), their illness narrative and how they present their symptoms to the health service. SETTING: Three London (UK) hospitals (coronary care units and medical wards). PARTICIPANTS: Patients were recruited with diabetes mellitus (DM) (types 1 and 2) with a clinical presentation of MI (ST elevated MI (STEMI), non-ST elevated MI (NSTEMI), acute MI unspecified and cardiac arrest)...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28918409/qualitative-interview-study-of-parents-perspectives-concerns-and-experiences-of-the-management-of-lower-respiratory-tract-infections-in-children-in-primary-care
#7
Amy Halls, Catherine Van't Hoff, Paul Little, Theo Verheij, Geraldine M Leydon
OBJECTIVE: To explore parents' perspectives, concerns and experiences of the management of lower respiratory tract infections (LRTIs) in children in primary care. DESIGN: Qualitative semistructured interview study. SETTING: UK primary care. PARTICIPANTS: 23 parents of children aged 6 months to 10 years presenting with LRTI in primary care. METHOD: Thematic analysis of semistructured interviews (either in person or by telephone) conducted with parents to explore their experiences and views on their children being prescribed antibiotics for LRTI...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28918408/effectiveness-cost-utility-and-implementation-of-a-decision-aid-for-patients-with-localised-prostate-cancer-and-their-partners-study-protocol-of-a-stepped-wedge-cluster-randomised-controlled-trial
#8
Hoda H M Al-Itejawi, Cornelia F van Uden-Kraan, Peter M van de Ven, Veerle M H Coupé, André N Vis, Jakko A Nieuwenhuijzen, Jeroen A van Moorselaar, Irma M Verdonck-de Leeuw
INTRODUCTION: Patient decision aids (PDAs) have been developed to help patients make an informed choice for a treatment option. Despite proven benefits, structural implementation falls short of expectations. The present study aims to assess the effectiveness and cost-utility of the PDA among newly diagnosed patients with localised prostate cancer and their partners, alongside implementation of the PDA in routine care. METHODS/ANALYSIS: A stepped-wedge cluster randomised trial will be conducted...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28918407/burden-of-non-adherence-to-latent-tuberculosis-infection-drug-therapy-and-the-potential-cost-effectiveness-of-adherence-interventions-in-canada-a-simulation-study
#9
Anik R Patel, Jonathon R Campbell, Mohsen Sadatsafavi, Fawziah Marra, James C Johnston, Kirsten Smillie, Richard T Lester
OBJECTIVE: Pharmaceutical treatment of latent tuberculosis infection (LTBI) reduces the risk of progression to active tuberculosis (TB); however, poor adherence tempers the protective effect. We aimed to estimate the health burden of non-adherence, the maximum allowable cost of hypothetical new adherence interventions to be cost-effective and the potential value of existing adherence interventions for patients with low-risk LTBI in Canada. DESIGN: A microsimulation model of LTBI progression over 25 years...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28912196/correction-in-patients-presenting-to-the-emergency-department-with-skin-and-soft-tissue-infections-what-is-the-diagnostic-accuracy-of-point-of-care-ultrasonography-for-the-diagnosis-of-abscess-compared-to-the-current-standard-of-care-a-systematic-review-and
#10
LETTER
https://www.readbyqxmd.com/read/28912195/associations-between-participation-in-organised-physical-activity-in-the-school-or-community-outside-school-hours-and-neighbourhood-play-with-child-physical-activity-and-sedentary-time-a-cross-sectional-analysis-of-primary-school-aged-children-from-the-uk
#11
Russell Jago, Corrie Macdonald-Wallis, Emma Solomon-Moore, Janice L Thompson, Debbie A Lawlor, Simon J Sebire
OBJECTIVES: To assess the extent to which participation in organised physical activity in the school or community outside school hours and neighbourhood play was associated with children's physical activity and sedentary time. DESIGN: Cross-sectional study. SETTING: Children were recruited from 47 state-funded primary schools in South West England. PARTICIPANTS: 1223 children aged 8-9 years old. OUTCOME MEASURES: Accelerometer-assessed moderate-to-vigorous-intensity physical activity (MVPA) and sedentary time...
September 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28912194/assessing-oral-medication-adherence-among-patients-with-type-2-diabetes-mellitus-treated-with-polytherapy-in-a-developed-asian-community-a-cross-sectional-study
#12
Cia Sin Lee, Jane Hwee Mian Tan, Usha Sankari, Yi Ling Eileen Koh, Ngiap Chuan Tan
OBJECTIVES: The disease burden of type 2 diabetes mellitus (T2DM) is rising due to suboptimal glycaemic control leading to vascular complications. Medication adherence (MA) directly influences glycaemic control and clinical consequences. This study aimed to assess the MA of patients with T2DM and identify associated factors. DESIGN: Analysis of data from a cross-sectional survey and electronic medical records. SETTING: Primary care outpatient clinic in Singapore...
September 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28912193/effectiveness-of-a-multifactorial-intervention-based-on-an-application-for-smartphones-heart-healthy-walks-and-a-nutritional-workshop-in-patients-with-type-2-diabetes-mellitus-in-primary-care-emid-study-protocol-for-a-randomised-controlled-trial
#13
Rosario Alonso-Domínguez, Manuel A Gómez-Marcos, Maria C Patino-Alonso, Natalia Sánchez-Aguadero, Cristina Agudo-Conde, Carmen Castaño-Sánchez, Luis García-Ortiz, José I Recio-Rodríguez
INTRODUCTION: New information and communication technologies (ICTs) may promote lifestyle changes, but no adequate evidence is available on their combined effect of ICTs with multifactorial interventions aimed at improving diet and increasing physical activity in patients with type 2 diabetes mellitus (DM2). The primary objective of this study is to assess the effect of a multifactorial intervention to increase physical activity and adherence to Mediterranean diet in DM2. METHODS AND ANALYSIS: Study scope and population: The study will be conducted at 'La Alamedilla' primary care research unit in Salamanca (Spain)...
September 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28912192/mechanical-cervical-ripening-for-women-with-prolongedpregnancies-magpop-protocol-for-a-randomised-controlled-trial-of-a-silicone-double-balloon-catheter-versus-the-propess-system-for-the-slow-release-of-dinoprostone-for-cervical-ripening-of-prolonged-pregnancies
#14
Caroline Diguisto, Amélie Le Gouge, Bruno Giraudeau, Franck Perrotin
INTRODUCTION: Induction of labour for prolonged pregnancies (PP) when the cervix is unfavourable is a challenging situation. Cervical ripening by pharmacological or mechanical techniques before oxytocin administration is used to increase the likelihood of vaginal delivery. Both techniques are equally effective in achieving vaginal delivery but excessive uterine activity, which induces fetal heart rate (FHR) anomalies, is more frequent after the pharmacological intervention. We hypothesised that mechanical cervical ripening could reduce the caesarean rate for non-reassuring FHR especially in PP where fetuses are already susceptible to this...
September 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28912191/high-versus-low-energy-administration-in-the-early-phase-of-acute-pancreatitis-goulash-trial-protocol-of-a-multicentre-randomised-double-blind-clinical-trial
#15
Katalin Márta, Anikó N Szabó, Dániel Pécsi, Péter Varjú, Judit Bajor, Szilárd Gódi, Patrícia Sarlós, Alexandra Mikó, Kata Szemes, Mária Papp, Tamás Tornai, Áron Vincze, Zsolt Márton, Patrícia A Vincze, Erzsébet Lankó, Andrea Szentesi, Tímea Molnár, Roland Hágendorn, Nándor Faluhelyi, István Battyáni, Dezső Kelemen, Róbert Papp, Attila Miseta, Zsófia Verzár, Markus M Lerch, John P Neoptolemos, Miklós Sahin-Tóth, Ole H Petersen, Péter Hegyi
INTRODUCTION: Acute pancreatitis (AP) is an inflammatory disease with no specific treatment. Mitochondrial injury followed by ATP depletion in both acinar and ductal cells is a recently discovered early event in its pathogenesis. Importantly, preclinical research has shown that intracellular ATP delivery restores the physiological function of the cells and protects from cell injury, suggesting that restoration of energy levels in the pancreas is therapeutically beneficial. Despite several high quality experimental observations in this area, no randomised trials have been conducted to date to address the requirements for energy intake in the early phase of AP...
September 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28903969/healing-journey-a-qualitative-analysis-of-the-healing-experiences-of-americans-suffering-from-trauma-and-illness
#16
John Glenn Scott, Sara L Warber, Paul Dieppe, David Jones, Kurt C Stange
OBJECTIVES: To elucidate pathways to healing for people having suffered injury to the integrity of their function as a human being. METHODS: A team of physician-analysts conducted thematic analyses of in-depth interviews of 23 patients who experienced healing, as identified by six primary care physicians purposefully selected as exemplary healers. RESULTS: People in the sample experienced healing journeys that spanned a spectrum from overcoming unspeakable trauma and then becoming healers themselves to everyday heroes functioning well despite ongoing serious health challenges...
September 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28903968/what-factors-are-associated-with-reporting-lacking-interest-in-sex-and-how-do-these-vary-by-gender-findings-from-the-third-british-national-survey-of-sexual-attitudes-and-lifestyles
#17
Cynthia A Graham, Catherine H Mercer, Clare Tanton, Kyle G Jones, Anne M Johnson, Kaye Wellings, Kirstin R Mitchell
OBJECTIVES: To investigate factors associated with reporting lacking interest in sex and how these vary by gender. SETTING: British general population. DESIGN: Complex survey analyses of data collected for a cross-sectional probability sample survey, undertaken 2010-2012, specifically logistic regression to calculate age-adjusted OR (AOR) to identify associated factors. PARTICIPANTS: 4839 men and 6669 women aged 16-74 years who reported ≥1 sexual partner (opposite-sex or same-sex) in the past year for the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3)...
September 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28899892/does-internet-based-cognitive-behaviour-therapy-reduce-healthcare-costs-and-resource-use-in-treatment-of-social-anxiety-disorder-a-cost-minimisation-analysis-conducted-alongside-a-randomised-controlled-trial
#18
Samir El Alaoui, Erik Hedman-Lagerlöf, Brjánn Ljótsson, Nils Lindefors
OBJECTIVES: Social anxiety disorder (SAD) can be effectively treated with internet-delivered cognitive behavioural therapy (ICBT), but studies on long-term cost minimisation from a healthcare provider perspective in comparison to an evidence-based control treatment of therapeutic equivalence are lacking. The objective of the study was to determine whether ICBT reduces healthcare costs and use of healthcare resources compared with cognitive behavioural group therapy (CBGT). DESIGN: A cost-minimisation study alongside a randomised controlled trial where participants (n=126) with SAD were randomised to ICBT or to CBGT...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28899891/effect-of-anesthesia-depth-on-postoperative-clinical-outcome-in-patients-with-supratentorial-tumor-depth-study-protocol-for-a-randomized-controlled-trial
#19
Qianyu Cui, Yuming Peng, Xiaoyuan Liu, Bo Jia, Jia Dong, Ruquan Han
INTRODUCTION: Recent studies have shown that deep anaesthesia is associated with poor outcomes. However, no randomised controlled trials have been conducted to test the causality in patients undergoing brain tumour resection. METHODS AND ANALYSIS: DEPTH is a multicenter, randomised, parallel-group, blind trial. The depth of general anaesthesia will be monitored using the bispectral index (BIS). Patients elected for supratentorial tumour resection will be randomly allocated to the deep or the light anaesthesia group in which the target BIS value is 35 or 50, respectively...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28899890/what-is-the-impact-of-research-champions-on-integrating-research-in-mental-health-clinical-practice-a-quasiexperimental-study-in-south-london-uk
#20
Sherifat Oduola, Til Wykes, Dan Robotham, Tom K J Craig
OBJECTIVES: Key challenges for mental health healthcare professionals to implement research alongside clinical activity have been highlighted, such as insufficient time to apply research skills and lack of support and resources. We examined the impact of employing dedicated staff to promote research in community mental health clinical settings. DESIGN: Quasiexperiment before and after study. SETTING: South London and Maudsley National Health Service Foundation Trust...
September 11, 2017: BMJ Open
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