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Pregnancy Hypertension

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https://www.readbyqxmd.com/read/29395656/serum-protein-marker-panel-for-predicting-preeclampsia
#1
Lifeng Cui, Chang Shu, Zitao Liu, Weihua Tong, Miao Cui, Chengguo Wei, Jian Jenny Tang, Xiufen Liu, Hujing Hai, Jing Jiang, Jin He, David Y Zhang, Fei Ye, Yulin Li
BACKGROUND: Preeclampsia is a multi-system disorder in pregnancy which has no effective treatment. The diagnosis of preeclampsia is based on clinical presentation and routine laboratory tests. OBJECTIVE: This study aimed at identifying serum protein markers for diagnosis of preeclampsia and predicting its severe features. STUDY DESIGN: In total, 172 pregnant women were enrolled in this study including 110 subjects with preeclampsia and 62 normotensive subjects...
January 29, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29472019/dynamics-of-serum-c-type-natriuretic-peptide-as-predictor-for-preeclampsia
#2
Lorenz Kuessel, Harald Zeisler, Gottfried Himmler, Michael Kundi, Eliana Montanari, Julia Binder, Heinrich Husslein, Julian Marschalek, Johannes Ott
OBJECTIVE: To evaluate serum levels of the amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) in uneventful pregnancies and pregnancies complicated by preeclampsia (PE) and NTproCNP's accuracy for prediction of PE. STUDY DESIGN: Nested case control pilot study including women with uneventful pregnancy (Control, n = 100) and asymptomatic women who later developed PE (PE_long, n = 12). NTproCNP levels were measured in a maximum of ten sequential blood samples per patient (seven visits during pregnancy, three afterwards), which had been collected prospectively...
January 12, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29242046/the-feasibility-and-acceptability-of-self-testing-for-proteinuria-during-pregnancy-a-mixed-methods-approach
#3
Katherine L Tucker, Liza Bowen, Carole Crawford, Philippa Mallon, Lisa Hinton, Mei-Man Lee, Jason Oke, Kathryn S Taylor, Carl Heneghan, Clare Bankhead, Lucy Mackillop, Tim James, Pippa Oakeshott, Lucy C Chappell, Richard J McManus
OBJECTIVE: To investigate feasibility and acceptability of self-testing for proteinuria during pregnancy. STUDY DESIGN: Mixed methods approach which included: an accuracy study where pregnant women (n = 100) and healthcare professionals (n = 96) tested seven synthetic protein samples and completed a questionnaire, a feasibility study where pregnant women who were self-monitoring their blood pressure were asked to self-test for proteinuria (n = 30), and an online questionnaire about women's experiences of self-testing (n = 200)...
November 23, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29199016/microvascular-disease-during-pregnancy-in-type-1-diabetes-is-associated-with-ambulatory-arterial-stiffness
#4
Ingvild Holm Tjessem, Hanine Fadel Mustafa Al-Far, Jens Fuglsang, Finn Friis Lauszus
OBJECTIVES: The objective of this study was to evaluate the association between the ambulatory arterial stiffness index (AASI) and markers of microvascular disease during pregnancy in women with type 1 diabetes. STUDY DESIGN: A total of 151 women with type 1 diabetes mellitus were recruited for repeat 24-h BP recordings thrice during pregnancy and once three months post partum. Fifty women without diabetes served as controls. The AASI and pulse pressure (PP) were computed from blood pressure recordings...
November 23, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29198741/pregnancy-as-an-early-stress-test-for-cardiovascular-and-kidney-disease-diagnosis
#5
Thaís Alquezar Facca, Gianna Mastroianni-Kirsztajn, Amélia Rodrigues Pereira Sabino, Michelle Tiveron Passos, Larissa Fátima Dos Santos, Eduardo Augusto Brosco Famá, Sonia Kiyomi Nishida, Nelson Sass
OBJECTIVES: Pregnancy is a cardiometabolic and renal stress test for women, primarily when associated with hypertension syndrome, which can have deleterious effects in the long term. We undertook this study to make a long-term evaluation on these women. STUDY DESIGN: A retrospective cohort study was conducted to investigate voluntary women who had pregnancy-induced hypertension syndrome versus normal pregnancy. MAIN OUTCOME MEASURES: We evaluated a total of 85 women, divided in case (n = 25) and control (n = 60) groups, by clinical, anthropometric and epidemiological profiles, general, metabolic and renal tests, and risk stratification for cardiovascular disease (CVD) and chronic kidney disease (CKD)...
November 23, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29183791/transforming-growth-factor-beta-1-related-gene-polymorphisms-in-gestational-hypertension-and-preeclampsia-a-case-control-candidate-gene-association-study
#6
Xun Li, Hongzhuan Tan, Mengshi Chen, Shujin Zhou
OBJECTIVES: To investigate the association between transforming growth factor beta 1 related gene polymorphisms and the occurrence of pregnancy induced hypertension, including gestational hypertension and preeclampsia. STUDY DESIGN: This is a case control candidate gene association study. A total of 130 patients with preeclampsia, 67 with gestational hypertension, and 316 controls were recruited. Eleven candidate SNPs of were examined, including four TGFβ1 SNPs (rs1800469, rs4803455, rs4803457, and rs8179181), one TGFβR1 SNP (rs10739778), four TGFβR2 SNPs (rs1346907, rs3087465, rs6550005, and rs877572), and two ENG SNPs (rs10121110 and rs11792480)...
November 23, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29198742/prediction-of-adverse-maternal-outcomes-from-pre-eclampsia-and-other-hypertensive-disorders-of-pregnancy-a-systematic-review
#7
REVIEW
U Vivian Ukah, Dane A De Silva, Beth Payne, Laura A Magee, Jennifer A Hutcheon, Helen Brown, J Mark Ansermino, Tang Lee, Peter von Dadelszen
BACKGROUND: The hypertensive disorders of pregnancy are a leading cause of maternal and perinatal mortality and morbidity. The ability to predict these complications using simple tests could aid in management and improve outcomes. We aimed to systematically review studies that reported on potential predictors of adverse maternal outcomes among women with a hypertensive disorder of pregnancy. METHODS: We searched MEDLINE, Embase and CINAHL (inception - December 2016) for studies of predictors of severe maternal complications among women with a hypertensive disorder of pregnancy...
November 21, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29175171/early-warning-system-hypertension-thresholds-to-predict-adverse-outcomes-in-pre-eclampsia-a-prospective-cohort-study
#8
Hannah L Nathan, Paul T Seed, Natasha L Hezelgrave, Annemarie De Greeff, Elodie Lawley, John Anthony, David R Hall, Wilhelm Steyn, Lucy C Chappell, Andrew H Shennan
OBJECTIVES: To evaluate the association between blood pressure (BP) measurements and adverse outcomes in women with pre-eclampsia. STUDY DESIGN: A prospective cohort study of women with pre-eclampsia admitted to three South African tertiary facilities. BP was measured using the CRADLE Vital Signs Alert (VSA), incorporated with a traffic light early warning system; green: systolic BP <140 mmHg and diastolic BP <90 mmHg, yellow: systolic BP 140-159 and/or diastolic BP 90-109 mmHg (but neither is above the upper threshold), red: systolic BP ≥160 mmHg and/or diastolic BP ≥110 mmHg...
November 21, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29175170/first-trimester-mean-arterial-blood-pressure-and-the-risk-of-preeclampsia-the-great-obstetrical-syndromes-gos-study
#9
Cédric Gasse, Amélie Boutin, Maxime Coté, Nils Chaillet, Emmanuel Bujold, Suzanne Demers
OBJECTIVE: To estimate the predictive value of first-trimester mean arterial pressure (MAP) for the hypertensive disorders of pregnancy (HDP). STUDY METHODS: We performed a prospective cohort study of nulliparous women recruited at 110/7-136/7 weeks. MAP was calculated from blood pressure measured on both arms simultaneously using an automated device taking a series of recordings until blood pressure stability was reached. MAP was reported as multiples of the median adjusted for gestational age...
November 21, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29175169/outcome-of-pregnancy-with-new-onset-proteinuria-and-progression-to-pre-eclampsia-a-retrospective-analysis
#10
Wai Hang Chung, William Wing Kee To
OBJECTIVE: To examine maternal and neonatal outcomes of gestational proteinuria, and to identify maternal characteristics for progression to pre-eclampsia. STUDY DESIGN: Retrospective cohort. Included all pregnant women who delivered between Jan 2014-Feb 2017 with new onset proteinuria in a single obstetric unit. Demographic, maternal and neonatal outcomes were compared. RESULTS: Eighteen (25%) out of 73 women with new onset gestational proteinuria developed pre-eclampsia...
November 21, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29203340/decidual-acvr2a-regulates-extravillous-trophoblast-functions-of-adhesion-proliferation-migration-and-invasion-in-vitro
#11
Hannah E J Yong, Padma Murthi, Bill Kalionis, Rosemary J Keogh, Shaun P Brennecke
Decidual stromal cells form the largest proportion of maternal cells at the maternal-fetal interface. Our aim was to investigate the role of the pre-eclampsia associated decidual activin receptor, ACVR2A, in regulating trophoblast functions at this interface. St-T1b and HTR-8/SVneo cell lines were used to model decidual stromal and trophoblast cells respectively. St-T1b conditioned medium inhibited HTR-8/SVneo adhesion, proliferation, migration and invasion; all effects that were attenuated by decidual ACVR2A siRNA transfection...
November 14, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29133069/relaxin-2-connecting-peptide-pro-rlx2-levels-in-second-trimester-serum-samples-to-predict-preeclampsia
#12
Miriam Rehfeldt, Elizabeth Eklund, Joachim Struck, Andrea Sparwasser, Barbara O'Brien, Glenn E Palomaki, Josef Köhrle, Andreas Bergmann, Geralyn Lambert-Messerlian
OBJECTIVES: Preeclampsia is a serious complication of pregnancy, threatening fetal and maternal health. The aim of our study is to examine the association between preeclampsia and the connecting peptide of the pregnancy hormone relaxin (pro-RLX2) as a potential new biochemical marker. STUDY DESIGN: This is a nested case/control study derived from the cohort of pregnancies delivering at Women & Infants Hospital. Cases were identified at a clinic or by hospital codes, and individually confirmed by record review...
November 7, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29113718/pregnancy-outcomes-in-women-with-previous-gestational-hypertension-a-cohort-study-to-guide-counselling-and-management
#13
Diane Nzelu, Dan Dumitrascu-Biris, Katharine F Hunt, Mark Cordina, Nikos A Kametas
OBJECTIVES: In pregnant women with previous gestational hypertension: to compare the prevalence of preeclampsia as defined by the 2001 versus the 2014 International Society for the Study of Hypertension in Pregnancy (ISSHP) criteria, to determine the rates of fetal growth restriction (FGR) as defined, not only by birthweight centile, but in combination with fetal ultrasound studies and, finally, to determine rates of other related outcomes such as gestational diabetes (GDM) and obstetric cholestasis (OC)...
November 4, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29102596/assessment-of-novel-cardiovascular-biomarkers-in-women-with-a-history-of-recurrent-miscarriage
#14
M M Wagner, J W Jukema, W Hermes, S le Cessie, C J M de Groot, J A Bakker, J M M van Lith, K W M Bloemenkamp
OBJECTIVES: A history of recurrent miscarriage is associated with future cardiovascular disease. The aim of this study was to determine novel cardiovascular biomarkers in women with a history of recurrent miscarriage as this might lead to a better understanding of the association. STUDY DESIGN: Women who visited the recurrent miscarriage clinic at Leiden University Medical Centre (between 2000 and 2010), and had three consecutive miscarriages ≤30 years were invited to participate in this follow-up study (between 2012 and 2014)...
October 28, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29111424/abnormal-mid-trimester-cardiac-strain-in-women-with-chronic-hypertension-predates-superimposed-preeclampsia
#15
Sajid Shahul, Hadi Ramadan, Ariel Mueller, Junaid Nizamuddin, Rabab Nasim, Joana Lopes Perdigao, Sireesha Chinthala, Avery Tung, Sarosh Rana
BACKGROUND: Chronic hypertension (cHTN) affects 7% of all pregnancies. We hypothesized that cHTN during pregnancy would be associated with abnormal myocardial strain patterns and adverse perinatal outcomes. METHODS: This was a retrospective cohort study of patients seen in a high-risk obstetrics clinic with cHTN. Parturients with a singleton pregnancy who had undergone an echocardiogram as part of routine clinical care were eligible. Clinical and demographic information was collected from medical records...
October 23, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29102595/interest-of-speckle-tracking-in-the-detection-of-cardiac-involvement-in-pregnant-women-with-hypertensive-disorder
#16
H Ajmi, D Abid, S Milouchi, D Louati, A Sghaier, D Choura, K Chaaben, L Abid, S Kammoun
INTRODUCTION: Pre-eclampsia is associated with many cardiovascular disorders present even in asymptomatic women. Several echocardiographic parameters are used to identify them. However, these parameters may be normal until late in the course of the disease process. Which justifies using new and more sensitive techniques. PURPOSE: We sought to test the hypothesis of subclinical cardiac involvement in such patients, based on speckle tracking, and to check its sensitivity compared to the usual methods...
October 23, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29089251/longitudinal-study-to-assess-changes-in-arterial-stiffness-and-cardiac-output-parameters-among-low-risk-pregnant-women
#17
Mohamed Waseem Osman, Mintu Nath, Asma Khalil, David R Webb, Thompson G Robinson, Hatem A Mousa
AIM: A single-centre, prospective longitudinal study to assess changes in maternal arterial stiffness and cardiac output parameters among low-risk healthy pregnant women. METHODOLOGY: Thirty low-risk, healthy, pregnant women attending their routine antenatal dating ultrasound scan were recruited. Non-invasive assessment of arterial stiffness and cardiac output was undertaken at five gestational windows from 11 to 40 weeks of pregnancy. Data were analysed using a linear mixed model incorporating time and other relevant predictors as fixed effects, and patient as a random effect...
October 16, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153698/adolescent-pregnancy-maternal-and-fetal-outcomes-in-patients-with-and-without-preeclampsia
#18
Felly Bakwa-Kanyinga, Edimárlei Gonsales Valério, Vera Lúcia Bosa, Cecília Ogando Alfama, Marianna Sperb, Edison Capp, Janete Vettorazzi
OBJECTIVE: To determine the prevalence of preeclampsia (PE) in adolescents and to evaluate its association with risk factors for, and the occurrence of, adverse maternal and fetal outcomes. RESULTS: Of 3006 deliveries, 533 (17.7%) were from teenage mothers, with twenty-eight (5.3%) presenting PE; 17.8% of these cases were classed as severe. Vitamin and mineral supplementation was associated with the occurrence of PE (p=0.034). Puerperal complications and prematurity were more frequent in the PE group...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153697/increased-tissue-factor-expression-and-promoter-hypomethylation-in-preeclampsia-placentas-in-a-chinese-population
#19
Rui Liu, Qiang Ma, Anxin Wen, Gaiyan Tian, Meili Li, Wenjuan Wang, Weimin Wang
OBJECTIVES: To explore the relationship between expression of tissue factor and its methylation levels in the placentas of preeclampsia among Chinese Han population. METHODS: In this study, we explored gene manifestation or expression of tissue factor, and evaluated methylation levels of tissue factor promoter areas in 16 clinical preeclampsia placentas as well as 16 paired normal pregnancy placentas from the Chinese Han population. Real-time PCR, immunohistochemistry, Western blotting, and methylation-specific PCR were conducted...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153696/dysregulation-of-circulating-autoantibodies-against-vegf-a-vegfr-1-and-plgf-in-preeclampsia-a-role-in-placental-and-vascular-health
#20
Kjartan Moe, Harald Heidecke, Ralf Dechend, Anne Cathrine Staff
OBJECTIVES: Preeclampsia is a state of antiangiogenesis, with high levels of maternal circulating sVEGFR-1 (soluble vascular endothelial growth factor receptor 1, also named sFlt1) and low levels of PlGF (placenta growth factor). Various autoantibodies have been detected in preeclamptic patients. We hypothesize that circulating autoantibodies against VEGF-A (AA-VEGF-A), VEGFR-1 (AA-VEGFR-1) and PlGF (AA-PlGF) are present in preeclamptic women, with different levels from pregnant women with normotensive pregnancies...
October 2017: Pregnancy Hypertension
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