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Pregnancy Hypertension

Karalyn E McRae, Nichole Peterson, Megan A Dickson, Graeme N Smith
No abstract text is available yet for this article.
October 2018: Pregnancy Hypertension
Zhang Pengjie, Chen Xionghui, Zhang Yueming, Xu Ting, Li Na, Tao Jianying, Xu Zhice
OBJECTIVE: To evaluate the role of lncRNA uc003fir in the progression and development of preeclampsia (PE). DESIGN: Paired test using placental tissue collected from PE women and normally pregnant women. SETTING: First Hospital of Soochow University, Suzhou, China. POPULATION: 38 women with PE versus 42 normally pregnant women matched maternal and gestational age with the same-size ratio. METHODS: Placental samples were analyzed using a human lncRNA microarray, and then the lncRNA uc003fir was validated by q-PCR...
October 2018: Pregnancy Hypertension
Tor Skibsted Clemmensen, Martin Christensen, Camilla Jensenius Skovhus Kronborg, Ulla Breth Knudsen, Brian Bridal Løgstrup
OBJECTIVES: This study compares differences in the long-term myocardial function between women with early (EOPE) and late onset preeclampsia (LOPE) and age matched normotensive controls using two-dimensional speckle tracking echocardiography. METHODS: The study population comprised 93 women who gave birth at Department of Gynecology and Obstetrics, Randers Regional Hospital between 1998 and 2008. The women were grouped as EOPE (n = 31), LOPE (n = 22), and women with previous normotensive pregnancies (n = 40)...
October 2018: Pregnancy Hypertension
Ahmed Alanwar, Ayman Abou El Nour, Mohamed El Mandooh, Ibrahim A Abdelazim, Luma Abbas, Ahmed M Abbas, Ameer Abdallah, Wael S Nossair, Shikanova Svetlana
OBJECTIVE: The current study aims to assess the efficacy of fetal middle cerebral artery/umbilical artery pulsatility index ratio (cerebroplacental ratio CPR) in predicting the occurrence of adverse perinatal outcomes in pregnancies complicated with severe pre-eclampsia. MATERIALS AND METHODS: This cohort study included 100 pregnant women between 34 and 40 weeks of gestation attended the labor ward and diagnosed with severe pre-eclampsia. Doppler evaluation was carried out to measure the CPR...
October 2018: Pregnancy Hypertension
Sebastian Kwiatkowski, Magdalena Bednarek-Jędrzejek, Joanna Ksel, Piotr Tousty, Ewa Kwiatkowska, Aneta Cymbaluk, Rafał Rzepka, Anita Chudecka-Głaz, Barbara Dołęgowska, Andrzej Torbè
We explored whether there was a relationship between the sFlt-1/PlGF ratio in early-late and late-onset SGA patients and whether it is associated with neonatal birth weight. MATERIAL/METHODS: 110 patients who were diagnosed with a fetal weight below the 10th percentile for gestational age and who at the same time delivered neonates with a birth weight below the 10th percentile for gestational age. For each of the patients sFlt-1, PlGF and the sFlt-1/PlGF ratio were studied and uterine artery (UtA) and umbilical artery (UA) Doppler were performed...
October 2018: Pregnancy Hypertension
Fergus P McCarthy, Roisin M Ryan, Lucy C Chappell
Preterm pre-eclampsia (prior to 37 weeks' gestation) remains a major cause of maternal and fetal morbidity and mortality particularly in low to middle income countries. Much research has focused on first and second trimester predictors of pre-eclampsia with the aim of allowing stratification of antenatal care and trialling of potential preventative and therapeutic agents. However, none have been shown to be of benefit in randomised controlled trials. In this literature review we critically evaluate predictive and diagnostic tests for preterm pre-eclampsia and discuss their clinical use and potential value in the management of preterm pre-eclampsia...
October 2018: Pregnancy Hypertension
Cheng-Qiu Lu, Jie Lin, Lin Yuan, Jian-Guo Zhou, Kun Liang, Qing-Hua Zhong, Jin-Hua Huang, Li-Ping Xu, Hui Wu, Zhi Zheng, Li-Li Ping, Yi Sun, Zhan-Kui Li, Ling Liu, Qin Lyu, Chao Chen
OBJECTIVE: To identify the effect of pregnancy induced hypertension on neonatal outcomes in early and moderate preterm infants of gestational age less than 34 weeks. STUDY DESIGN: Prospectively collected data in 773 premature deliveries less than 34 weeks from 10 centers in China between July 2014 and July 2016 were analyzed in this cohort study. Univariate and Multivariate regression analyses were conducted to exam the effect of pregnancy induced hypertension on neonatal outcomes, including mortality to discharge, intrauterine growth restriction, severe brain injury, neonatal respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, early onset of sepsis and retinopathy of prematurity...
October 2018: Pregnancy Hypertension
Lisha Zhu, Ruitu Lv, Lingchun Kong, Xiaotian Li
Preeclampsia (PE) is a pregnancy-specific syndrome affecting up to 8% of pregnancies worldwide. While PE is a leading cause of maternal and neonatal mortality and morbidity, the pathophysiology of PE is unclear to date. Here, we have verified that dysregulation of CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) and zinc finger DHHC-type containing 14 (ZDHHC14) via DNA methylation plays a vital role in late-onset PE pathology. Our study confirmed the differentially methylated regions (DMRs) of the CD39 and ZDHHC14 gene bodies that we found previously in clinical samples of preeclamptic placentas by MassARRAY EpiTYPER...
October 2018: Pregnancy Hypertension
Megha Gupta, Naomi Greene, Sarah J Kilpatrick
OBJECTIVE: To determine if timely treatment within 60 min of confirmed diagnosis of severe maternal hypertension with antihypertensive medications was associated with reduction in severe maternal morbidity. STUDY DESIGN: Medical records of women with severe hypertension (at least two severe blood pressures, systolic ≥160 mmHg and/or diastolic ≥110 mmHg, within 60 min) were accessed for timing of severe blood pressures, timing of treatment, and blood pressure response to treatment...
October 2018: Pregnancy Hypertension
I Cavero-Redondo, V Martínez-Vizcaíno, A Soriano-Cano, J A Martínez-Hortelano, G Sanabria-Martínez, C Álvarez-Bueno
OBJECTIVE: To examine the relationship between the increase of glycated haemoglobin A1c (HbA1c) levels and the risk of preeclampsia in pregnant with type 1 diabetes mellitus; and to determine from which trimester the increase of HbA1c levels better predicts the risk of suffering preeclampsia in type 1 diabetic pregnant women. METHODS: We systematically searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews and Web of Science databases, from inception to May 2017, for observational studies addressing the association of HbA1c levels with preeclampsia...
October 2018: Pregnancy Hypertension
Yong-Gang Zhang, Hong-Ling Yang, Yi-Peng Zhang, Qing-Ling Ma, Yan Long, Zao-Xiong Zheng
BACKGROUND: Imbalance of circulating factors related to angiogenesis plays a central role in the pathogenesis of preeclampsia (PE). OBJECTIVE: The aim of this study was to discover and validate a cutoff value of pigment epithelium-derived factor (PEDF)/vascular endothelial growth factor (VEGF) ratio for early prediction of PE before 20 weeks of gestation. STUDY DESIGN: This prospective multicenter study was performed in mainland China, and was divided into 3 phases to discover, develop, and validate a cutoff value of PEDF/VEGF ratio that could predict PE prior to diagnosis in pregnant women at high risk of PE (12 weeks 0 days to 19 weeks 6 days of gestation)...
October 2018: Pregnancy Hypertension
Trung Huu Nguyen, Thanh Cong Bui, Tuan Minh Vo, Quan Minh Tran, Loan Thi-Thanh Luu, Tai Duy Nguyen
BACKGROUND: It has been suggested that soluble fms-like tyrosine kinase receptor-1 (sFlt-1) and placental growth factor (PlGF) play potential roles in preeclampsia diagnosis. Nevertheless, studies on the use of sFlt-1, PlGF, and sFlt-1/PlGF ratio in predicting preeclampsia have found contradictory results. Thus, more studies in different populations are needed. OBJECTIVES: This study aims to (i) examine the associations between sFlt-1, PlGF, or sFlt-1/PlGF ratio at gestational ages of 24-28 weeks and subsequent preeclampsia, and (ii) estimate predictive values of these markers in southern Vietnamese women...
October 2018: Pregnancy Hypertension
Priscila Rezeck Nunes, Maria Terezinha Serrao Peracoli, Mariana Romao-Veiga, Mariana Leticia Matias, Vanessa Rocha Ribeiro, Celio Junior Da Costa Fernandes, Jose Carlos Peracoli, Jose Ricardo Rodrigues, Leandro De Oliveira
BACKGROUND: The placenta is a multifunctional organ that can suffer with imbalances between pro- and antioxidant molecules, contributing for inflammatory imbalance. The inflammation generated by oxidative stress may induce inflammasome activation, an essential complex for pro-inflammatory cytokine production. OBJECTIVE: The aim of this study was to evaluate whether hydrogen peroxide (H2 O2 ) mediated oxidative stress induces inflammasome activation on placental explants...
October 2018: Pregnancy Hypertension
Mohamed Waseem Osman, Mintu Nath, Asma Khalil, David R Webb, Thompson G Robinson, Hatem A Mousa
AIM: To assess the changes in haemodynamics amongst pregnant women who were screened for gestational diabetes mellitus (GDM) in comparison to low-risk healthy pregnant controls. METHODOLOGY: A total of 120 pregnant women of mean (standard deviation) age 31.03 (5.41) years who attended their oral glucose tolerance test as part of the national screening for GDM (study), and 60 low-risk healthy pregnant women (control) of mean age 29.71 (5.33) years, were invited to participate in this study...
October 2018: Pregnancy Hypertension
Lisa M Bodnar, Katherine P Himes, Barbara Abrams, Sara M Parisi, Jennifer A Hutcheon
OBJECTIVE: To investigate the association between early-pregnancy weight gain and risk of preeclampsia to inform pregnancy weight gain recommendations. STUDY DESIGN: We performed a case-cohort study using a hospital database including 80,812 singleton deliveries from Magee-Womens Hospital, Pittsburgh, Pennsylvania (1998-2011). In each of 6 prepregnancy body mass index (BMI) groups, we abstracted serial antenatal weight measurements from the records of up to 339 preeclampsia cases and 1254 randomly selected pregnancies...
October 2018: Pregnancy Hypertension
Diane Nzelu, Dan Dumitrascu-Biris, Polly Kay, Kypros H Nicolaides, Nikos A Kametas
OBJECTIVES: To compare rates of severe hypertension (SH), preeclampsia (PE) birth of small for gestational age (SGA) neonates between women with chronic hypertension (CH) diagnosed during the first trimester of pregnancy and those with pre-pregnancy CH. STUDY DESIGN: Prospective cohort study of women with CH and singleton pregnancies referred to an Antenatal Hypertension Clinic at 8-14 weeks' gestation. At presentation the patients were subdivided into four groups based on blood pressure (BP) control...
October 2018: Pregnancy Hypertension
Julian Marschalek, Peter Wohlrab, Johannes Ott, Johann Wojta, Walter Speidl, Klaus Ulrich Klein, Herbert Kiss, Petra Pateisky, Harald Zeisler, Lorenz Kuessel
OBJECTIVE: Oxidative stress and mitochondrial dysfunction may play a crucial role in preeclampsia (PE). The aim of this study was to investigate differences in maternal levels of serum-mitochondrial (mt) DNA, a proposed biomarker for mitochondrial dysfunction, in women with PE compared to healthy pregnant women. STUDY DESIGN: Using samples obtained from the prospective Biobank study, we measured serum-mtDNA levels in pregnant women diagnosed with PE and in women with uneventful pregnancies, matched for gestational and maternal age, BMI, and smoking status...
October 2018: Pregnancy Hypertension
Sara Buttrup Larsen, Gerd Wallukat, Ingolf Schimke, Anna Sandager, Therese Tvilum Christensen, Niels Uldbjerg, Niels Tørring
OBJECTIVES: Functional autoantibodies against Angiotensin II Receptor type 1 (AT1-AA) and Endothelin-1 Receptor type A (ETA-AA), which belong to the class of functional autoantibodies, have been discovered in patients with preeclampsia and in rodent models of pregnancy-induced hypertension. The aim of the study was to investigate the expression of these autoantibodies in relation to disease progression. STUDY DESIGN: We included 10 controls and 41 cases defined as patients with gestational-induced hypertension, preeclampsia or HELLP syndrome...
October 2018: Pregnancy Hypertension
Jiangfeng Ye, Yan Chen, Jing Zhu, Chang Chen, Xiaoyong Zhu, Liping Feng, Weiping Ye, Jun Zhang
OBJECTIVE: Aspirin has been shown to prevent preeclampsia. But the mechanisms remain unclear despite that improved placental circulation is considered as an underlying contributor. Our aim was to examine the hypoxia-related morphological and histopathological placental measures in relation to aspirin use during pregnancy. STUDY DESIGN: We used the Collaborative Perinatal Project (CPP) data, which is a cohort study conducted in the U.S. from 1959 to 1976. A total of 23, 604 women who had information on placental pathology and aspirin intake during pregnancy were included in the analysis...
October 2018: Pregnancy Hypertension
Chikako Hirashima, Takako Ohmaru-Nakanishi, Shiho Nagayama, Kayo Takahashi, Hirotada Suzuki, Hironori Takahashi, Rie Usui, Koumei Shirasuna, Shigeki Matsubara, Akihide Ohkuchi
Our aim was to evaluate whether serum levels of soluble LIGHT (sLIGHT) at 27-31 weeks can predict the later occurrence of gestational hypertension (GH), late-onset preeclampsia (PE), and early-onset PE. Mean blood pressure (MBP), soluble fma-like tyrosine kinase 1/placental growth factor (sFlt-1/PlGF) ratio at 27-31 weeks, and sLIGHT at 27-31 weeks were independent risk factors for late-onset PE. The combination of the three risk factors improved sensitivity with a false-positive rate of 10% (MBP: 60%, log10 (sFlt-1/PlGF): 45%, sLIGHT: 35%, combination: 75%)...
October 2018: Pregnancy Hypertension
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