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Pregnancy Hypertension

Mark A Brown, Laura A Magee, Louise C Kenny, S Ananth Karumanchi, Fergus P McCarthy, Shigeru Saito, David R Hall, Charlotte E Warren, Gloria Adoyi, Salisu Ishaku
No abstract text is available yet for this article.
May 23, 2018: Pregnancy Hypertension
K Winkler, C Contini, B König, B Krumrey, G Pütz, S Zschiedrich, U Pecks, D Stavropoulou, H Prömpeler, M Kunze, F Markfeld-Erol
OBJECTIVE: Soluble Fms-like tyrosine kinase-1 (sFlt-1) is thought to be causative in the pathogenesis of preeclampsia (PE) and specific removal of sFlt-1 via dextran sulfate cellulose (DSC)-apheresis was suggested as cure to allow prolongation of pregnancy in preterm PE. However, in addition a deranged lipoprotein metabolism may impact endothelial and placental function in PE. Lipoprotein-apheresis by heparin-mediated extracorporeal LDL-precipitation (H.E.L.P.) was previously applied and has been shown to alleviate symptoms in PE...
April 2018: Pregnancy Hypertension
Stine Fossum, Sigrun Halvorsen, Åse V Vikanes, Tessa J Roseboom, Inger Ariansen, Øyvind Næss
OBJECTIVE: To assess midlife cardiovascular risk profiles in women with a history of hyperemesis or hypertensive disorders in pregnancy compared to women with none of the studied pregnancy complications. STUDY DESIGN: Population-based study. Cardiovascular risk factors at the age of 40-45 among women with previous singleton births only were studied through linkage of the Norwegian Birth Registry and a Norwegian screening program (the Age 40 Program). MAIN OUTCOME MEASURES: Family history of coronary heart disease, body mass index, smoking, physical activity, systolic and diastolic blood pressure, heart rate, cholesterol, triglycerides, antihypertensive treatment and diabetes...
April 2018: Pregnancy Hypertension
Hirotada Suzuki, Chikako Hirashima, Shiho Nagayama, Kayo Takahashi, Tatsuo Yamamoto, Shigeki Matsubara, Akihide Ohkuchi
OBJECTIVE: Our first aim was to construct gestational-age-specific reference ranges of serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and the sFlt-1/PlGF ratio at 19-38 weeks of gestation. Our second aim was to compare the serum levels of sFlt-1, PlGF, and the sFlt-1/PlGF ratio in 81 women with PE which occurred at <32, 32-33, 34-35, and ≥36 weeks. METHOD: Serum levels of sFlt-1 and PlGF were measured by automated immunoassays (Elecsys sFlt-1 and Elecsys PlGF)...
April 2018: Pregnancy Hypertension
Sara Ornaghi, Paola Algeri, Lyudmyla Todyrenchuk, Emanuela Vertemati, Patrizia Vergani
OBJECTIVES: To investigate the effects of excessive pre-pregnancy body mass index (BMI) and abnormal gestational weight gain on adverse outcomes in women with chronic hypertension (CH). STUDY DESIGN: A retrospective cohort study of CH women with singleton pregnancy delivered at our Institution in 2002-2013. Women were categorized as normal, overweight, and obese, according to their pre-pregnancy BMI. Further stratification was based on gestational weight gain (insufficient, adequate, and excessive) as defined by 2009 IOM guidelines...
April 2018: Pregnancy Hypertension
Chung-Ying Lin, Anders Broström, Per Nilsen, Amir H Pakpour
OBJECTIVE: To use the Theory of Planned Behavior (TPB) combined with action and coping planning plus global relationship with husband to explain the aspirin adherence in a sample of women with high-risk pregnancy. METHODS: A total of 535 Iranian women (mean age = 32.29 ± 4.98; year of marriage = 6.89 ± 3.61) completed the study. Each participant filled out several questionnaires on TPB (i.e., a widely applied theory describing how behaviors are influenced by beliefs, attitudes, perceived behavioral control and behavioral intentions), action planning, coping planning and relationship with husband at baseline...
April 2018: Pregnancy Hypertension
Marylise Hebert-Schuster, Thimali Ranaweera, Camille Fraichard, Antoine Gaudet-Chardonnet, Vassilis Tsatsaris, Jean Guibourdenche, Edouard Lecarpentier
No abstract text is available yet for this article.
April 2018: Pregnancy Hypertension
Mayara Caldeira-Dias, Marcelo R Luizon, Elenice Deffune, Jose E Tanus-Santos, Paula P Freire, Robson F Carvalho, Heloisa Bettiol, Viviane C Cardoso, Marco Antonio Barbieri, Ricardo C Cavalli, Valéria C Sandrim
Preeclampsia is a major cause of maternal and fetal morbidity and mortality worldwide. It is a multisystem pregnancy syndrome characterized by general endothelial dysfunction caused mainly by plasma factors and debris in endothelial cells. It is widely accepted that endothelin-1 (ET-1) is involved in the pathophysiology of preeclampsia, and so it is of interest to ascertain whether the ET-1 gene (EDN1) can be targeted with tools such as miRNAs. Therefore, we investigated the relationship between the expression of miRNAs that putatively target EDN1 (and so affect ET-1 levels) in HUVECs incubated with plasma from preeclamptic women...
April 2018: Pregnancy Hypertension
J G Mangos, F Pettit, R Preece, K Harris, M A Brown
No abstract text is available yet for this article.
April 2018: Pregnancy Hypertension
Marina M Ziganshina, Elrad Y Amiraslanov, Ekaterina L Yarotskaya, Nataliya V Dolgushina, Olga A Sergunina, Marina A Nikolaeva, Natalia E Kan, Victor L Tyutyunnik, Diana A Mantrova, Natalya S Loginova, Alexandra O Konradi, Gennady T Sukhikh
No abstract text is available yet for this article.
April 2018: Pregnancy Hypertension
Eran Weiner, Ohad Feldstein, Liliya Tamayev, Ehud Grinstein, Elad Barber, Jacob Bar, Letizia Schreiber, Michal Kovo
OBJECTIVE: We aimed to compare pregnancy outcome and placental histopathology in women with preeclampsia (PE) with and without severe features. METHODS: The medical records and placental pathology reports of all pregnancies complicated by PE during 2008-2016, were reviewed. Results were compared between those with and without severe features (severe PE vs. mild PE groups), according to current ACOG guidelines. Placental lesions were classified to maternal/fetal vascular supply lesions, and maternal/fetal inflammatory responses...
April 2018: Pregnancy Hypertension
Joost H N Schuitemaker, Thomas I F H Cremers, Maria G Van Pampus, Sicco A Scherjon, Marijke M Faas
OBJECTIVE: We aimed to assess the levels of endothelial cell specific molecule 1 (ESM-1) during pregnancy and preeclampsia. METHODS: Plasma and placental samples were collected from women with a control pregnancy, early- or late-onset preeclamptic women and non-pregnant women (experiment 1). Plasma samples were collected between weeks 12 and birth from pregnant women at high risk for developing preeclampsia (experiment 2). ESM-1 plasma levels were measured by ELISA and in the placenta mRNA and protein were detected by immunohistochemistry and qPCR...
April 2018: Pregnancy Hypertension
Brandie D Taylor, Roberta B Ness, Mark A Klebanoff, Gong Tang, James M Roberts, David M Hougaard, Kristin Skogstrand, Catherine L Haggerty
OBJECTIVE: Small studies suggest that fetal sex alters maternal inflammation. We examined the association between fetal sex, preeclampsia and circulating maternal immune markers. METHODS: This was a secondary data analysis within a nested case-control study of 216 preeclamptic women and 432 randomly selected normotensive controls from the Collaborative Perinatal Project. All women had singleton, primiparous pregnancies without chronic health conditions. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for associations between female fetal sex and preeclampsia...
April 2018: Pregnancy Hypertension
Nnabuike C Ngene, Jagidesa Moodley
OBJECTIVE: The baseline blood pressure (BP) readings of an automated device that have not been validated in pregnancy require comparison with those from a reference standard before the device is utilized in pregnancy. We aimed to perform a baseline check of BP readings of an automated device, Mindray iMEC12 patient monitor, in severe pre-eclampsia and healthy pregnancy. STUDY DESIGN: The BP of 50 severe pre-eclamptic and 90 normotensive pregnancies were measured using Mindray iMEC12 patient monitor (test device) and Welch Allyn 767 aneroid sphygmomanometer (reference device)...
April 2018: Pregnancy Hypertension
Stephen Kyle Gonzales, Martina Badell, Hanh Cottrell, Bassam Rimawi, Venkataraman Deepak, Neil Sidell, Augustine Rajakumar
OBJECTIVES: Soluble Flt1 (sFlt1) is an anti-angiogenic protein linked to the pathology of preeclampsia (PE). While the placenta serves as the major organ producing sFlt1 during normal pregnancy, peripheral blood mononuclear cells (PBMCs), endothelial cells, and stromal cells also produce sFlt1. The key question is 'what drives the overexpression of sFlt1 observed during PE?' In the present work we show evidence for sFlt1 over-expression in PBMCs due to interaction with placental villi from PE patients...
April 2018: Pregnancy Hypertension
Vandana Bojja, Anish Keepanasseril, Pradeep P Nair, V C Sunitha
OBJECTIVE: To study the clinical and imaging profile of patients with new-onset seizures with a presumptive diagnosis of eclampsia. METHODS: This was a cross-sectional study, conducted in a tertiary teaching hospital, on pregnant women presenting with new onset seizures with presumptive diagnosis of eclampsia excluding those with pre-existing neurological conditions. Demographic details, medical and obstetric examination findings were noted. All women underwent neuroimaging within 5 days of onset seizures...
April 2018: Pregnancy Hypertension
M Gupta, B B Feinberg, R M Burwick
Thrombotic microangiopathy (TMA) disorders are characterized by microangiopathic hemolytic anemia, thrombocytopenia and end-organ injury. In pregnancy and postpartum, TMA is most commonly encountered with HELLP (hemolysis, elevated liver enzymes, low platelet count syndrome) or preeclampsia with severe features, but rarely TMA is due to thrombotic thrombocytopenic purpura (TTP) or atypical hemolytic uremic syndrome (aHUS). Due to overlapping clinical and laboratory features, TTP and aHUS are often mistaken for preeclampsia or HELLP...
April 2018: Pregnancy Hypertension
Lauren E Mak, B Anne Croy, Vanessa Kay, James N Reynolds, Matthew T Rätsep, Nils D Forkert, Graeme N Smith, Angelina Paolozza, Patrick W Stroman, Ernesto A Figueiró-Filho
BACKGROUND: Individuals (PE-F1s) born from preeclampsia (PE)-complicated pregnancies have elevated risks for cognitive impairment. Intervals of disturbed maternal plasma angiokines precede clinical signs of PE. We hypothesized pan-blastocyst dysregulation of angiokines underlies altered PE-F1 brain vascular and neurological development. This could alter brain functional connectivity (FC) patterns at rest. MATERIALS AND METHODS: Resting-state functional MRI datasets of ten, matched child pairs (5 boys and 5 girls aged 7-10 years of age) from PE or control pregnancies were available for study...
April 2018: Pregnancy Hypertension
Charlene Eliza Thornton, Hannah Grace Dahlen, Annemarie Hennessy
BACKGROUND: Induction of labour (IOL) is a common procedure yet we have little information on the efficacy of the process for women with a hypertensive disorder of pregnancy (HDP). OBJECTIVE: To describe the birth type and associated factors in nulliparous HDP women undergoing an induction of labour. STUDY DESIGN: Statutorily collected datasets on every birth and hospital admission which occurred in the state of NSW Australia between the years 2000-2011 were analysed...
April 2018: Pregnancy Hypertension
C Birdir, L Droste, L Fox, M Frank, J Fryze, A Enekwe, A Köninger, R Kimmig, B Schmidt, A Gellhaus
OBJECTIVES: The aim of this study was to investigate, whether maternal serum levels of sFlt-1, PlGF and PAPP-A at third trimester of pregnancy are associated with late-onset PE and intrauterine growth retardation (IUGR) after 34 weeks of pregnancy. METHODS: This was a prospective study measuring the maternal serum levels of soluble tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF) and pregnancy-associated plasma protein-A (PAPP-A) at 32-37 weeks of pregnancy: 730 patients were enrolled and 676 had neither intrauterine growth restriction (IUGR) nor preeclampsia (PE) or pregnancy induced hypertension (PIH) throughout the pregnancy...
April 2018: Pregnancy Hypertension
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