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Pregnancy Hypertension

Sebastian R Hobson, Rutu Acharya, Rebecca Lim, Siow Teng Chan, Joanne Mockler, Euan M Wallace
Circulating markers for endothelial activation such as endothelin-1 (ET-1), ICAM-1 and VCAM-1 are elevated in women with preeclampsia. Using human umbilical vein endothelial cells (HUVECs) as an in vitro model of the maternal vasculature, we show that activin A and preeclamptic serum upregulate ET-1, ICAM-1, and VCAM-1 in HUVECs. Further, we show that follistatin, a specific binding protein for activin, mitigates the upregulation of ET-1, ICAM-1 and VCAM-1 in HUVECs exposed to either activin A or preeclamptic serum...
April 2016: Pregnancy Hypertension
Haitham Torky, Asem Anwar, Alaa Elebrashy, Fahd Elomda
OBJECTIVES: To determine the prenatal incidence of moderate and severe cardiac anomalies and determine the prenatal pattern of CHD. STUDY DESIGN: Multi-center retrospective observational study. SETTINGS: Cairo, Al-Azhar and 6th October Universities. PATIENTS AND METHODS: 5499 pregnant women in the second and third trimester attending the fetal medicine unit in the three universities from January 2012 to June 2013 for anomaly scan were retrospectively reviewed...
April 2016: Pregnancy Hypertension
Hakan Timur, Halil Korkut Daglar, Ozgur Kara, Ayse Kirbas, Hasan Ali Inal, Gulenay Gencosmanoglu Turkmen, Zehra Yilmaz, Burak Elmas, Dilek Uygur
OBJECTIVE: To investigate Apo A-1 and Apo B-100 levels and Apo B-100/Apo A-1 ratios in preeclamptic (PE) patients. MATERIALS AND METHODS: Forty-eight PE and 48 without PE patients (healthy pregnancies) matched for gestational age were included. Maternal age, parity, gestational age at delivery, obstetrical complications including intrauterine growth restriction (IUGR) and gestational diabetes mellitus (GDM), serum Apo A-1 and Apo B-100 levels, and the Apo B-100/Apo A-1 ratio were compared...
April 2016: Pregnancy Hypertension
Binnur Bagci, Savas Karakus, Gokhan Bagci, Enver Sancakdar
BACKGROUND: Renalase is a novel enzyme that degrades circulating catecholamines. We aimed to investigate the role of rs2576178 and rs10887800 polymorphisms of the renalase gene in preeclampsia (PE) patients METHODS: This case-control study consisted of 110 women with PE and 102 normotensive controls. PCR-RFLP method was used for determination of renalase gene polymorphisms. RESULTS: Allele frequency and genotype distribution of rs10887800 polymorphism were found statistically significantly higher in women with PE (p<0...
April 2016: Pregnancy Hypertension
Martin Christensen, Camilla Skovhus Kronborg, Nikolaj Eldrup, Niklas Blach Rossen, Ulla Breth Knudsen
OBJECTIVES: Epidemiological studies associate preeclampsia with increased risk of premature cardiovascular disease (CVD) later in life. This study aims to make a comprehensive CVD risk assessment comparing women with previous preeclamptic pregnancies to women with previous normotensive pregnancies 10years after index pregnancy. STUDY DESIGN: A nested, matched, observational cohort study. MAIN OUTCOME MEASURES: Markers of arterial stiffness, aortic pulse wave velocity (aPWV) and augmentation index (AIx-75), and markers of atherosclerosis, carotid intima-media thickness (cIMT) and carotid plaque presence...
April 2016: Pregnancy Hypertension
Ulrik Dolberg Anderson, Magnus Gram, Jonas Ranstam, Basky Thilaganathan, Bo Kerström, Stefan R Hansson
OBJECTIVE: Overproduction of cell-free fetal hemoglobin (HbF) in the preeclamptic placenta has been recently implicated as a new etiological factor of preeclampsia. In this study, maternal serum levels of HbF and the endogenous hemoglobin/heme scavenging systems were evaluated as predictive biomarkers for preeclampsia in combination with uterine artery Doppler ultrasound. STUDY DESIGN: Case-control study including 433 women in early pregnancy (mean 13.7weeks of gestation) of which 86 subsequently developed preeclampsia...
April 2016: Pregnancy Hypertension
Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Natalie J Hannan, Fiona Brownfoot, Manarangi De Silva, Ping Cannon, Laura Tuohey, Stephen Tong
INTRODUCTION: Preeclampsia is a serious pregnancy complication for which there are no medical treatments. Soluble endoglin is an anti-angiogenic factor implicated in the pathogenesis of the disease, however little is known about its molecular regulation. The PI3K/Akt pathway is down regulated in preeclamptic placentas and decreased PI3K/Akt signaling has been linked to increased soluble endoglin release from endothelial cells. MMP14 is a key protease that functions to release soluble endoglin from the placental surface...
April 2016: Pregnancy Hypertension
Fatma Nihan Turhan Çağlar, Cem Ozde, Evrim Bostancı, İlker Murat Çağlar, Serkan Çiftçi, İsmail Unğan, Bülent Demir, Osman Karakaya
BACKGROUND: Preeclampsia (PE) is a multisystemic disorder characterized by hypertension and proteinuria that is specific to pregnancy and associated with maternal and fetal morbidity-mortality. AIM: To assess right heart structure and function in PE by echocardiography using conventional and tissue Doppler techniques. METHODS: In total, 67 women with untreated PE and 46 matched healthy pregnant women were included. PE was defined according to the ACOG (2002) criteria...
April 2016: Pregnancy Hypertension
Mushi Matjila, Robert Millar, Zephne van der Spuy, Arieh Katz
OBJECTIVE: To investigate the placental mRNA and protein expression of metastasis suppressor gene Kiss-1 and the transcript expression of its receptor GPR-54 across the maternal-fetal interface of healthy and preeclamptic pregnancies. To furthermore compare placental tissue kisspeptin expression to circulatory kisspeptin levels in these pregnancies. SETTING: Secondary and Tertiary Hospital Setting in Cape Town, South Africa. POPULATION: Patients with and without preeclampsia undergoing elective caesarean delivery...
January 2016: Pregnancy Hypertension
Brandie D Taylor, Gong Tang, Roberta B Ness, Jørn Olsen, David M Hougaard, Kristin Skogstrand, James M Roberts, Catherine L Haggerty
OBJECTIVES: To determine if mid-pregnancy circulating immune biomarkers are associated with preeclampsia. STUDY DESIGN: Nested case-control study of 410 preeclamptic women and 297 normotensive controls with primiparous singleton pregnancies enrolled in the Danish National Birth Cohort. The mean gestational age in our cohort is 16 weeks (range 9-26). MAIN OUTCOME MEASURES: Preeclampsia was defined by blood pressure ⩾140/90 mmHg and proteinuria ⩾3 g/24 h...
January 2016: Pregnancy Hypertension
Xun Li, Hongzhuan Tan, Xin Huang, Shujin Zhou, Shimin Hu, Xiaojuan Wang, Xin Xu, Qian Liu, Shi Wu Wen
OBJECTIVES: To compare the risk factors for gestational hypertension (GH) and preeclampsia (PE) in the same population, which may provide clues to better understanding of their etiologic mechanisms. METHODS: We conducted a cohort study in Liuyang, China, during 2010-2011. Twelve potential risk factors were investigated, including maternal age, body mass index at first antenatal visit, gender of newborn, parity, abortion history, smoking history, family history of hypertension, gestational diabetes mellitus, pregnancy complications of diabetes mellitus/renal disease/cardiac disease, reproductive tract infection, season of delivery, and district level average per capita income...
January 2016: Pregnancy Hypertension
Kim M Holwerda, M Susanne Weedon-Fekjær, Anne C Staff, Ilja M Nolte, Harry van Goor, A Titia Lely, Marijke M Faas
OBJECTIVES: Preeclampsia (PE) is a pregnancy complication, characterized by hypertension and proteinuria. The transsulfuration pathway may be involved in its pathophysiology, since homocysteine, cystathionine and cysteine are increased in PE. Cystathionine-β-synthase (CBS) is a key-enzyme in the pathway, converting homocysteine into cysteine via cystathionine. Another product of CBS is hydrogen sulfide (H2S), a vasodilatory, proangiogenic and cytoprotective gas that is thought to play a role in placental and vascular function during pregnancy...
January 2016: Pregnancy Hypertension
Órlaith Burke, Samantha Benton, Pawel Szafranski, Peter von Dadelszen, S Catalin Buhimschi, Irene Cetin, Lucy Chappell, Francesc Figueras, Alberto Galindo, Ignacio Herraiz, Claudia Holzman, Carl Hubel, Ulla Knudsen, Camilla Kronborg, Hannele Laivuori, Olav Lapaire, Thomas McElrath, Manfred Moertl, Jenny Myers, Roberta B Ness, Leandro Oliveira, Gayle Olson, Lucilla Poston, Carrie Ris-Stalpers, James M Roberts, Sarah Schalekamp-Timmermans, Dietmar Schlembach, Eric Steegers, Holger Stepan, Vassilis Tsatsaris, Joris A van der Post, Stefan Verlohren, Pia M Villa, David Williams, Harald Zeisler, Christopher W G Redman, Anne Cathrine Staff
BACKGROUND: A common challenge in medicine, exemplified in the analysis of biomarker data, is that large studies are needed for sufficient statistical power. Often, this may only be achievable by aggregating multiple cohorts. However, different studies may use disparate platforms for laboratory analysis, which can hinder merging. METHODS: Using circulating placental growth factor (PlGF), a potential biomarker for hypertensive disorders of pregnancy (HDP) such as preeclampsia, as an example, we investigated how such issues can be overcome by inter-platform standardization and merging algorithms...
January 2016: Pregnancy Hypertension
X L Li, P L Guo, Y Xue, W L Gou, M Tong, Q Chen
Preeclampsia is clinically divided into early onset and late onset preeclampsia based on the gestational age at delivery. Although the diagnostic criteria are the same in each subgroup of preeclampsia, it has been suggested that the maternal and perinatal mortalities of early onset and late onset preeclampsia are different. However, studies that compare clinical parameters or laboratory biomarkers between early onset and late onset preeclampsia are limited. Data on 177 women with early or late preeclampsia with severe hypertension were collected from a University Teaching Hospital from January 2010 to January 2011 and analysed...
January 2016: Pregnancy Hypertension
Budi Rahayu, Siti Candra Windu Baktiyani, Nurdiana Nurdiana
This study aims to investigate whether an ethanolic extract of Theobroma cacao bean is able to increase cell viability and decrease IL-6 and sVCAM-1 in endothelial cells induced by plasma from preeclamptic patients. Endothelial cells were obtained from human umbilical vascular endothelial cells. At confluency, endothelial cells were divided into six groups, which included control (untreated), endothelial cells exposed to plasma from normal pregnancy, endothelial cells exposed to 2% plasma from preeclamptic patients (PP), endothelial cells exposed to PP in the presence of ethanolic extract of T...
January 2016: Pregnancy Hypertension
Ayse Kirbas, Ozgur Kirbas, Korkut Daglar, Hasan Ali Inal, Ozge Kurmus, Ozgur Kara, Hakan Timur, Gulenay Gencosmanoglu, Nuri Danisman
OBJECTIVE: There is increasing evidence that preeclampsia (PE) may also be a risk factor for future cardiovascular diseases (CVDs), including arrhythmia. In this study we aimed to evaluate the association between PE and ventricular repolarization using novel electrocardiogram markers: QT interval duration, Tp-e interval, and Tp-e/QT ratio. MATERIALS AND METHODS: In this controlled cross-sectional study sixty-four pregnant women with PE (31 with mild and 33 with severe disease) and 32 healthy women with uncomplicated pregnancies in the third trimester were compared by measuring QT parameters, Tp-e interval, and Tp-e/QT ratio...
January 2016: Pregnancy Hypertension
Gloria Valdés, Stephanie Acuña, Alejandro Munizaga, Gloria X Soto, Carlos D Figueroa
The bradykinin type 2 receptor (B2R), main effector of the pleiotropic kallikrein-kinin system (KKS), has been localized in the key sites related to placentation in human, rat and guinea pig utero-placental units. The present study was directed to characterize the content, the cellular and subcellular localization of B2R in the villi and basal plate of placentas from normal and preeclamptic pregnancies by means of western blotting, immunohistochemistry and immunoelectron microscopy. The protein content of B2R was demonstrated in both placental zones...
January 2016: Pregnancy Hypertension
Gökhan Inangil, Suleyman Deniz, Yasemin Gulcan Kurt, Ugur Keskin, Omer Bakal, Huseyin Sen, Sezai Ozkan, Ercan Kurt
OBJECTIVES: Butyrylcholinesterase (BChE), commonly known as pseudocholinesterase or non-neural cholinesterase, hydrolyzes neuromuscular blocker agents containing choline esters such as succinylcholine that is widely used in rapid sequence induction (RSI) for general anesthesia. The aim of this study is to compare plasma BChE levels and investigate the affects and relationship of succinylcholine on BChE levels in preeclamptic, gestational diabetic and healthy pregnants. STUDY DESIGN: We designed a prospective, controlled, pilot single-center study...
January 2016: Pregnancy Hypertension
Salih Serin, Fazıl Avcı, Onder Ercan, Bülent Köstü, Murat Bakacak, Hakan Kıran
OBJECTIVE: To evaluate the relationship of neutrophil/lymphocyte ratio (NLR) with proteinuria and blood pressure level in patients with pre-eclampsia and to investigate whether or not NLR has a role in predicting the severity of pre-eclampsia. STUDY DESIGN: The study comprised 30 healthy pregnant females (Group 1), 37 females with mild pre-eclampsia (Group 2) and 40 with severe pre-eclampsia (Group 3). All the study participants were statistically compared in respect of demographic data, proteinuria levels, and blood pressure levels...
January 2016: Pregnancy Hypertension
Qizhen Zheng, Yuqing Deng, Shilin Zhong, Yu Shi
OBJECTIVES: To assess whether human chorionic gonadotropin (HCG) and fetal sex are two independent risk factors for hypertensive pregnancy in the early second-trimester of pregnancy. METHODS: This was a retrospective nested case-control study based on a cohort of 2521 singleton pregnancies, among whom we recruited 98 hypertensive pregnancies (subdivided into severe preeclampsia, n=34; mild preeclampsia, n=29 and gestational hypertension, n=35) and 196 normotensive pregnancies...
January 2016: Pregnancy Hypertension
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