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Theranostics

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https://www.readbyqxmd.com/read/29930740/antibody-affinity-and-valency-impact-brain-uptake-of-transferrin-receptor-targeted-gold-nanoparticles
#1
Kasper Bendix Johnsen, Martin Bak, Paul Joseph Kempen, Fredrik Melander, Annette Burkhart, Maj Schneider Thomsen, Morten Schallburg Nielsen, Torben Moos, Thomas Lars Andresen
Rationale: The ability to treat invalidating neurological diseases is impeded by the presence of the blood-brain barrier (BBB), which inhibits the transport of most blood-borne substances into the brain parenchyma. Targeting the transferrin receptor (TfR) on the surface of brain capillaries has been a popular strategy to give a preferential accumulation of drugs or nanomedicines, but several aspects of this targeting strategy remain elusive. Here we report that TfR-targeted gold nanoparticles (AuNPs) can accumulate in brain capillaries and further transport across the BBB to enter the brain parenchyma...
2018: Theranostics
https://www.readbyqxmd.com/read/29930739/circular-rna-znf609-regulates-retinal-neurodegeneration-by-acting-as-mir-615-sponge
#2
Jia-Jian Wang, Chang Liu, Kun Shan, Bai-Hui Liu, Xiu-Miao Li, Shu-Jie Zhang, Rong-Mei Zhou, Rui Dong, Biao Yan, Xing-Huai Sun
Glaucoma is a major cause of visual impairment characterized by progressive retinal neurodegeneration. Circular RNAs are a class of endogenous noncoding RNAs that regulate gene expression in eukaryotes. In this study, we investigated the role of cZNF609 in retinal neurodegeneration induced by glaucoma. Methods: qRT-PCR and Sanger sequencing were conducted to detect cZNF609 expression pattern during retinal neurodegeneration. Immunofluorescence staining was conducted to detect the effect of cZNF609 silencing on retinal neurodegeneration in vivo...
2018: Theranostics
https://www.readbyqxmd.com/read/29930738/molecular-detection-of-inflammation-in-cell-models-using-hyperpolarized-13-c-pyruvate
#3
Renuka Sriram, Julia Nguyen, Justin DeLos Santos, Linda Nguyen, Jinny Sun, Seth Vigneron, Mark Van Criekinge, John Kurhanewicz, John D MacKenzie
The detection and treatment monitoring of inflammatory states remain challenging in part due to the multifactorial mechanisms of immune activation and spectrum of clinical manifestations. Currently, diagnostic strategies tend to be subjective and limited quantitative tools exist to monitor optimal treatment strategies. Pro-inflammatory M1 polarized macrophages exhibit a distinct metabolic glycolytic phenotype compared to the continuum of M2 polarization states. In the present study, the distinct metabolic phenotypes of resting and activated macrophages were successfully characterized and quantified using hyperpolarized carbon-13 (13 C) labeled pyruvate and its metabolic products, i...
2018: Theranostics
https://www.readbyqxmd.com/read/29930737/comparison-of-burnet-s-clonal-selection-theory-with-tumor-cell-clone-development
#4
Borros Arneth
Increasing evidence has shown that Darwin's theory of evolution provides vital insights into the emergence and etiology of different types of cancer. On a microscopic scale, cancer stem cells meet the conditions for the Darwinian process of natural selection. In particular, cancer stem cells undergo cell reproduction characterized by the emergence of heritable variability that promotes replication and cell survival. Methods: Evidence from previous studies was gathered to compare Burnet's clonal selection theory with the tumor evolution theory...
2018: Theranostics
https://www.readbyqxmd.com/read/29930736/somatostatin-receptor-type-2-as-a-radiotheranostic-pet-reporter-gene-for-oncologic-interventions
#5
Pedram Heidari, Anchisa Kunawudhi, Jordi Martinez-Quintanilla, Alicia Szretter, Khalid Shah, Umar Mahmood
Reporter gene systems can serve as therapy targets. However, the therapeutic use of reporters has been limited by the challenges of transgene delivery to a majority of cancer cells. This study specifically assesses the efficacy of targeting human somatostatin receptor subtype 2 (hSSTR2) with peptide receptor radionuclide therapy (PRRT) when a small subpopulation of cells bears the transgene. Methods: The hSSTR2 transgene was delivered to A549 and Panc-1tumors using the lentiviral vector, LV-hSSTR2-IRES-GFP or murine mesenchymal stem cells (mMSC)s using a retroviral vector...
2018: Theranostics
https://www.readbyqxmd.com/read/29930735/functional-role-of-btb-and-cnc-homology-1-gene-in-pancreatic-cancer-and-its-association-with-survival-in-patients-treated-with-gemcitabine
#6
Xudong Huang, Jian Zheng, Jun Li, Xu Che, Wenle Tan, Wen Tan, Mingming Shao, Xinxin Cheng, Zhongli Du, Yanjie Zhao, Chengfeng Wang, Chen Wu, Dongxin Lin
Genetic variation (rs372883C/T) in the 3'-untranslated region of BTB and CNC homology 1 ( BACH1 ) has been associated with pancreatic ductal adenocarcinoma (PDAC) risk in our previous genome-wide association study; however, the action roles of this genetic variation in PDAC remains unknown. Methods: BACH1 expression was measured by quantitative real-time PCR, Western blot and immunohistochemistry. The effects of BACH1 on cell proliferation and sensitivity to gemcitabine were examined by alteration of BACH1 expression in PDAC cells...
2018: Theranostics
https://www.readbyqxmd.com/read/29930734/extracellular-vesicles-as-markers-and-mediators-in-sepsis
#7
REVIEW
Pierre Raeven, Johannes Zipperle, Susanne Drechsler
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. It remains a highly lethal condition in which current tools for early diagnosis and therapeutic decision-making are far from ideal. Extracellular vesicles (EVs), 30 nm to several micrometers in size, are released from cells upon activation and apoptosis and express membrane epitopes specific for their parental cells. Since their discovery two decades ago, their role as biomarkers and mediators in various diseases has been intensively studied...
2018: Theranostics
https://www.readbyqxmd.com/read/29930733/precision-guided-long-acting-analgesia-by-gel-immobilized-bupivacaine-loaded-microsphere
#8
Wenjing Zhang, Cong Ning, Weiguo Xu, Hanze Hu, Mingqiang Li, Guoqing Zhao, Jianxun Ding, Xuesi Chen
Peripheral nerve blockade (PNB) is a conventional strategy for the management of acute postoperative pain. However, the short duration of the associated analgesia and the potential systemic toxicity due to the low molecular weights of local anesthetics limit their application. Methods: An in situ forming injectable Gel-microsphere (Gel-MS) system consisting of PLGA-PEG-PLGA Gel (Gel) and Gel-immobilized bupivacaine-loaded microsphere (MS/BUP) was prepared for precision-guided long-acting analgesia. A series of in vitro characterizations, such as scanning electron microscopy, rheology analysis, confocal laser scanning microscopy, drug release, and erosion and degradation, were carried out...
2018: Theranostics
https://www.readbyqxmd.com/read/29930732/injectable-opf-graphene-oxide-hydrogels-provide-mechanical-support-and-enhance-cell-electrical-signaling-after-implantation-into-myocardial-infarct
#9
Jin Zhou, Xiaoning Yang, Wei Liu, Chunlan Wang, Yuan Shen, Fengzhi Zhang, Huimin Zhu, Hongji Sun, Jiayun Chen, Johnny Lam, Antonios G Mikos, Changyong Wang
After myocardial infarction (MI), the scar tissue contributes to ventricular dysfunction by electrically uncoupling viable cardiomyocytes in the infarct region. Injection of a conductive hydrogel could not only provide mechanical support to the infarcted region, but also synchronize contraction and restore ventricular function by electrically connecting isolated cardiomyocytes to intact tissue. Methods: We created a conductive hydrogel by introducing graphene oxide (GO) nanoparticles into oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels...
2018: Theranostics
https://www.readbyqxmd.com/read/29930731/response-to-single-low-dose-177-lu-dota-eb-tate-treatment-in-patients-with-advanced-neuroendocrine-neoplasm-a-prospective-pilot-study
#10
Hao Wang, Yuejuan Cheng, Jingjing Zhang, Jie Zang, Hui Li, Qingxing Liu, Jingnan Wang, Orit Jacobson, Fang Li, Zhaohui Zhu, Xiaoyuan Chen
Objective: 177 Lu-DOTA-EB-TATE is a theranostic agent based on octreotate that uses an Evans blue structure to bind albumin to improve the pharmacokinetics and pharmacodynamics. This pilot study aims to evaluate the efficacy of a single low-dose treatment using 177 Lu-DOTA-EB-TATE in patients with advanced neuroendocrine neoplasm (NEN). Methods: With IRB approval and informed consent, 4 NEN patients were enrolled to undergo 177 Lu-DOTA-EB-TATE treatment with a single low dose of 0.66 ± 0.06 GBq (17.8 ± 1...
2018: Theranostics
https://www.readbyqxmd.com/read/29930730/shape-size-and-structure-controlled-synthesis-and-biocompatibility-of-iron-oxide-nanoparticles-for-magnetic-theranostics
#11
REVIEW
Wensheng Xie, Zhenhu Guo, Fei Gao, Qin Gao, Dan Wang, Bor-Shuang Liaw, Qiang Cai, Xiaodan Sun, Xiumei Wang, Lingyun Zhao
In the past decade, iron oxide nanoparticles (IONPs) have attracted more and more attention for their excellent physicochemical properties and promising biomedical applications. In this review, we summarize and highlight recent progress in the design, synthesis, biocompatibility evaluation and magnetic theranostic applications of IONPs, with a special focus on cancer treatment. Firstly, we provide an overview of the controlling synthesis strategies for fabricating zero-, one- and three-dimensional IONPs with different shapes, sizes and structures...
2018: Theranostics
https://www.readbyqxmd.com/read/29930729/colorimetric-in-situ-assay-of-membrane-bound-enzyme-based-on-lipid-bilayer-inhibition-of-ion-transport
#12
Juan Zhang, Defeng Li, Xiquan Yue, Meiling Zhang, Ping Liu, Genxi Li
Membrane-bound enzymes (MBEs), which make up a very high proportion of intracellular enzymes, catalyze a variety of activities that are currently analyzed by various techniques after purification. However, due to their amphipathic character, the purification of MBEs is difficult. Therefore, the most productive approach represents in situ analysis of MBEs in the cellular membrane. Methods: In this study, using membrane-bound α-glucosidase (α-Glu) as an example, we have developed a colorimetric in situ assay for MBEs based on the inhibitory effect of lipid bilayer on ion transport...
2018: Theranostics
https://www.readbyqxmd.com/read/29930728/glypican-3-targeted-precision-diagnosis-of-hepatocellular-carcinoma-on-clinical-sections-with-a-supramolecular-2d-imaging-probe
#13
Hai-Hao Han, Yu-Jiao Qiu, Yuan-Yuan Shi, Wen Wen, Xiao-Peng He, Li-Wei Dong, Ye-Xiong Tan, Yi-Tao Long, He Tian, Hong-Yang Wang
The ability of chemical tools to effectively detect malignancy in frozen sections removed from patients during surgery is important for the timely determination of the subsequent surgical program. However, current clinical methods for tissue imaging rely on dye-based staining or antibody-based techniques, which are sluggish and complicated. Methods: Here, we have developed a 2D material-based supramolecular imaging probe for the simple, rapid yet precise diagnosis of hepatocellular carcinoma (HCC). The 2D probe is constructed through supramolecular self-assembly between a water soluble, fluorescent peptide ligand that selectively targets glypican-3 (GPC-3, a specific cell-surface biomarker for HCC) and 2D molybdenum disulfide that acts as a fluorescence quencher as well as imaging enhancer...
2018: Theranostics
https://www.readbyqxmd.com/read/29930727/a-tightly-controlled-src-yap-signaling-axis-determines-therapeutic-response-to-dasatinib-in-renal-cell-carcinoma
#14
Jingya Sun, Xin Wang, Boyun Tang, Hongchun Liu, Minmin Zhang, Yueqin Wang, Fangfang Ping, Jian Ding, Aijun Shen, Meiyu Geng
Over the past decade, therapies targeting the VEGF/VEGFR and mTOR pathways have served as the standard of care for the clinical management of renal cell carcinoma (RCC) patients. Albeit promising, these targeted drugs have attained only modest clinical benefits with limited prolonged progression-free survival. Therefore, alternative reasonable and applicable therapeutic approaches should be introduced to improve the clinical outcome of RCC patients. Methods: FDA approved kinase inhibitors were screened to evaluate their abilities to suppress the proliferation of RCC cells...
2018: Theranostics
https://www.readbyqxmd.com/read/29930726/rich-club-disturbances-of-the-human-connectome-from-subjective-cognitive-decline-to-alzheimer-s-disease
#15
Tianyi Yan, Wenhui Wang, Liu Yang, Kewei Chen, Rong Chen, Ying Han
Alzheimer's disease (AD) has a preclinical phase that can last for decades prior to clinical dementia onset. Subjective cognitive decline (SCD) is regarded as the last preclinical AD stage prior to the development of amnestic mild cognitive decline (aMCI) and AD dementia (d-AD). The analysis of brain structural networks based on diffusion tensor imaging (DTI) has identified the so-called 'rich club', a set of cortical regions highly connected to each other, with other regions referred to as peripheral. It has been reported that rich club architecture is affected by regional atrophy and connectivity, which are reduced in patients with aMCI and d-AD...
2018: Theranostics
https://www.readbyqxmd.com/read/29930725/oncogenic-trim31-confers-gemcitabine-resistance-in-pancreatic-cancer-via-activating-the-nf-%C3%AE%C2%BAb-signaling-pathway
#16
Chao Yu, Shiyu Chen, Yuntao Guo, Chengyi Sun
Background: Drug resistance is well known as a major obstacle for cancer recurrence and treatment failure, leading to poor survival in pancreatic cancer, which is a highly aggressive tumor. Identifying effective strategies to overcome drug resistance would have a significant clinical impact for patients with pancreatic cancer. Methods: The protein and mRNA expression of TRIM31 in pancreatic cancer cell lines and patient tissues were determined using Real-time PCR and Western blot, respectively. 89 human pancreatic cancer tissue samples were analyzed by IHC to investigate the association between TRIM31 expression and the clinicopathological characteristics of pancreatic cancer patients...
2018: Theranostics
https://www.readbyqxmd.com/read/29930724/serum-amyloid-p-component-therapeutically-attenuates-atherosclerosis-in-mice-via-its-effects-on-macrophages
#17
Dan Xi, Jinzhen Zhao, Kai Guo, Lu Hu, Hui Chen, Weijun Fu, Wenyan Lai, Zhigang Guo
Background: A hallmark of atherosclerosis is the formation of macrophage-derived foam cells. Serum amyloid P component (SAP), a member of the pentraxin family of proteins, is known to affect macrophage activation. However, the role of SAP in atherosclerosis is still unclear. Methods: Apolipoprotein E-deficient (Apoe-/- ) mice fed a high-fat diet were given intraperitoneal injections of SAP (6 mg/kg) every other day for a total of 2 weeks to characterize atherosclerosis development. Results: We showed that intraperitoneal injection of SAP attenuated atherosclerosis in Apoe-/- mice...
2018: Theranostics
https://www.readbyqxmd.com/read/29930723/dna-damage-predicts-prognosis-and-treatment-response-in-colorectal-liver-metastases-superior-to-immunogenic-cell-death-and-t-cells
#18
Johannes Laengle, Judith Stift, Agnes Bilecz, Brigitte Wolf, Andrea Beer, Balazs Hegedus, Stefan Stremitzer, Patrick Starlinger, Dietmar Tamandl, Dietmar Pils, Michael Bergmann
Preclinical models indicate that DNA damage induces type I interferon (IFN), which is crucial for the induction of an anti-tumor immune response. In human cancers, however, the association between DNA damage and an immunogenic cell death (ICD), including the release and sensing of danger signals, the subsequent ER stress response and a functional IFN system, is less clear. Methods: Neoadjuvant-treated colorectal liver metastases (CLM) patients, undergoing liver resection in with a curative intent, were retrospectively enrolled in this study (n=33)...
2018: Theranostics
https://www.readbyqxmd.com/read/29930722/a-hook-effect-free-immunochromatographic-assay-hef-ica-for-measuring-the-c-reactive-protein-concentration-in-one-drop-of-human-serum
#19
Jusung Oh, Hyou-Arm Joung, Hyung Soo Han, Jong Kun Kim, Min-Gon Kim
The immunochromatographic (ICA) assay is a highly promising platform for rapid and simple detection of C-reactive protein (CRP) which is an indicator of the different phases of various diseases, as well as of inflammation and infection. However, the hook effect in the ICA assay limits the quantification of CRP levels at high CRP concentrations. Methods: In this study, we developed a hook effect-free immunochromatographic assay (HEF-ICA) to detect CRP over a wide concentration range. The hook effect results from the simultaneous reaction of an excess target antigens with both immobilized and labeled antibodies respectively...
2018: Theranostics
https://www.readbyqxmd.com/read/29930721/the-her2-inhibitor-lapatinib-potentiates-doxorubicin-induced-cardiotoxicity-through-inos-signaling
#20
Wan-Tseng Hsu, Ching-Ying Huang, Christopher Y T Yen, Ann-Lii Cheng, Patrick C H Hsieh
Rationale: Lapatinib (LAP) is a crucial alternative to trastuzumab upon the onset of drug resistance during treatment of metastatic human epidermal growth factor receptor 2-positive breast cancer. Like trastuzumab, LAP is commonly used alongside anthracyclines as a combination therapy, due to enhanced anti-cancer efficacy. However, this is notably associated with cardiotoxicity so it is imperative to understand the mechanisms driving this cardiotoxicity and develop cardioprotective strategies. To this end, here we utilize human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs), which exhibit several characteristics representative of in vivo cardiomyocytes that make them breakthrough models to study drug toxicity...
2018: Theranostics
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