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Journal of Pharmacology & Pharmacotherapeutics

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https://www.readbyqxmd.com/read/27651716/effect-of-losartan-and-atenolol-on-insulin-sensitivity-in-nondiabetic-hypertensive-patients
#1
K B Rakesh, Sheetal D Ullal, B Sunil Pai
No abstract text is available yet for this article.
July 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27651715/randomized-controlled-comparison-of-agomelatine-and-escitalopram-concerns-about-study-design-and-methods
#2
Sutanaya Pal, Ekta Franscina Pinto, Nitin B Raut, Girish Banwari, Chittaranjan Andrade
No abstract text is available yet for this article.
July 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27651714/clofazimine-induced-premaculopathy-in-a-vitiliginous-patient
#3
Nirupama Kasturi, Renuka Srinivasan
A 26-year-old male vitiliginous patient presented with decreased visual acuity because of a central scotoma in the left eye with no significant retinal changes on fundus examination. In this case report, a diagnosis of possible drug-induced premaculopathy was made, and the drugs were withdrawn. On the follow-up, after 3 months, the visual acuity in the left eye gradually improved. Early suspicion of drug-induced maculopathy and withdrawal of the drug may prevent the progression of maculopathy.
July 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27651713/cyclophosphamide-and-epirubicin-induced-diabetes-mellitus-in-breast-cancer-a-rare-occurrence
#4
Pramod Kumar Sharma, Arup Kumar Misra, Vikram Singh, Ajay Gupta, Shrishti Saroha, Surjit Singh
Breast cancer is the leading cause of death in women. Epirubicin and cyclophosphamide (EC) is one of the chemotherapeutic regimens used for the treatment of breast cancer. We describe a case treated with EC regimen and who presented to us with symptoms suggestive of diabetes mellitus postchemotherapy. Absence of family history of diabetes and normal blood sugar level, prechemotherapy points toward drug-induced hyperglycemia. These chemotherapeutic agents capable of altering immune response and might act synergistically to cause immunological damage to the islets of pancreas which might precipitate diabetes mellitus...
July 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27651712/oxcarbazepine-induced-drug-rash-with-eosinophilia-and-systemic-symptoms-syndrome-presenting-as-exfoliative-dermatitis
#5
Mahimanjan Saha, Surajit Gorai, Vaswatee Madhab
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a type of severe adverse cutaneous drug reaction characterized by fever, skin eruption, hematological abnormalities, and internal organ involvement. Although anticonvulsant drugs are mainly implicated in DRESS, newer anticonvulsants such as oxcarbazepine-induced definite cases of DRESS syndrome are rare and oxcarbazepine-induced DRESS syndrome presenting as exfoliative dermatitis is even rarer. We report a case of a 35-year-old male who developed DRESS syndrome presenting as exfoliative dermatitis after taking oxcarbazepine for 3 weeks...
July 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27651711/cisplatin-resistance-reversal-by-disulfiram-and-caffeine
#6
Ashish R Kadia, Gaurang B Shah
No abstract text is available yet for this article.
July 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27651710/cold-sodium-chloride-solution-0-9-and-infrared-thermography-can-be-an-alternative-to-radiopaque-contrast-agents-in-phlebography
#7
Aleksandr Livievich Urakov, Anton Aleksandrovic Kasatkin, Natalia Aleksandrovna Urakova, Tatiana Viktorovna Urakova
No abstract text is available yet for this article.
July 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27651709/deprescription-the-prescription-metabolism
#8
REVIEW
Gurusamy Sivagnanam
Deprescribing is a structured approach to drug discontinuation. An alternative suggested term is "prescription metabolism." The major aim of deprescription is to purge the drug(s) considered unwanted in a given patient, especially in the elderly patients with multiple comorbidities or in those suffering from chronic disease. Like drug metabolism, prescription metabolism is a way of eliminating unwanted, troublesome, or cost-ineffective medications. The removal of such drugs has been found to decrease the incidence of adverse drug reactions and improves the rate of medication adherence, thereby reducing the economic burden on the patient as well as on the health care providers...
July 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27651708/phenytoin-induced-toxic-epidermal-necrolysis-review-and-recommendations
#9
REVIEW
Osama M Al-Quteimat
Toxic epidermal necrolysis (TEN) is a serious, life-threatening skin reaction characterized by severe exfoliation and destruction of the epidermis of the skin. In most TEN cases, drugs are believed to be the causative agent; antipsychotics, antiepileptics, and other medications such as sulfonamides are among the most common causes of drug-induced TEN. Phenytoin, a commonly prescribed medication for seizure, was found to cause TEN. Evidence-based treatment guidelines are lacking, so the best strategy is to identify and avoid potential risk factors and to provide intensive supportive care...
July 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27651707/what-failed-bia-10-2474-phase-i-clinical-trial-global-speculations-and-recommendations-for-future-phase-i-trials
#10
Rimplejeet Kaur, Preeti Sidhu, Surjit Singh
No abstract text is available yet for this article.
July 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27651706/the-three-rs-of-written-assessment-the-jipmer-experience
#11
EDITORIAL
S Manikandan, B Gitanjali
No abstract text is available yet for this article.
July 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27440960/acute-hepatic-injury-with-amphotericin-b-deoxycholate-in-an-immunocompetent-patient
#12
Jamie L Wagner, Allison M Bell
Amphotericin B deoxycholate (AmBd) is rarely used due to its adverse effect profile, which includes nephrotoxicity, infusion-related reactions, and hepatotoxicity. The incidence of hepatotoxicity related to AmBd is 18-23%, but the reports of this adverse effect are mainly in immunocompromised patients receiving chemotherapy. We report a case of AmBd-related acute hepatic injury in an immunocompetent male with multiple medical problems. The patient initially had acute hepatic injury likely caused by poor nutritional status and a diagnosis of failure to thrive, but was recovering...
April 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27440959/fixed-drug-eruption-due-to-levocetirizine
#13
Ratinder Jhaj, Dinesh Prasad Asati, Deepa Chaudhary
A fixed drug eruption (FDE) is a cutaneous adverse drug reaction due to Type IV or delayed cell-mediated hypersensitivity. Antihistamines, which antagonize the action of histamine during an allergic reaction by blocking the H1 histamine receptors, are used routinely for the treatment of various allergic disorders such as urticaria, eczemas, and also in itchy lesions of skin like scabies. Levocetirizine, an active (R)-enantiomer of cetirizine, is a newer or second generation antihistamine, with more specific actions and fewer side effects, including cutaneous reactions...
April 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27440958/a-case-of-figurate-urticaria-by-etanercept
#14
Maurizio Sessa, Maria Giuseppa Sullo, Annamaria Mascolo, Daniela Cimmaruta, Francesca Romano, Rosa Valentina Puca, Annalisa Capuano, Francesco Rossi, Ada Lo Schiavo
Etanercept is a competitive inhibitor of tumor necrosis factor-alpha (TNF-α) a polypeptide hormone, involved in the development of the immune system, in host defense and immune surveillance. Even if the etanercept mechanism of action is not completely understood, it is supposed that it negatively modulates biological responses mediated by molecules (cytokines, adhesion molecules, or proteinases) induced or regulated by TNF. For this reason, it is widely used in the treatment of immunologicals diseases, such as rheumatoid and psoriatic arthritis, polyarticular juvenile idiopathic active, ankylosing spondylitis, and plaque psoriasis...
April 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27440957/qt-interval-prolongation-and-torsade-de-pointes-synergistic-effect-of-flecainide-and-h1-receptor-antagonists
#15
Carlos Acosta-Materán, Eloy Díaz-Oliva, Diego Fernández-Rodríguez, Julio Hernández-Afonso
A high percentage of patients having atrial fibrillation (AF) presents with paroxysmal AF. Flecainide, the prototypic class Ic anti-arrhythmic drug is the most effective drug to maintain sinus rhythm in this subgroup of patients, though the drug has potential pro-arrhythmic effects. Furthermore, the H1 receptor antagonists are the most commonly prescribed drugs for the symptomatic treatment of pruritus. Despite having low number of adverse effects, the H1 receptor antagonists have cardiotoxic effects. Flecainide and H1 receptor antagonists present arrhythmic complications including QT interval prolongation and torsade de pointes (TdP)...
April 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27440956/an-unusual-case-of-glipizide-induced-proximal-myopathy
#16
Saibal Das, Anand Ramasamy, Soumyadip De, Somnath Mondal
This case report outlines a very rare case of glipizide-induced severe proximal myopathy in a 61-year-old diabetic man. After taking 10 mg glipizide for 5 months, diabetes was well controlled but the patient presented with progressive proximal muscle weakness in all the four limbs. Clinical examination and relevant investigations suggested it to be a case of proximal myopathy and might be drug induced. De-challenge was done and was treated resulting in reversal of the diseased state. After 3 more months, controlled re-challenge was done and there was recurrence of proximal muscle weakness...
April 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27440955/warfarin-and-phenytoin-drug-interaction-with-possible-purple-glove-syndrome
#17
Carolyn S Hunter, Stephanie V Phan
Though the impact of phenytoin on warfarin has been reported to potentiate the anticoagulant effect or interact in a biphasic manner, the effect of phenytoin on warfarin appears to be unpredictable and dependent upon multiple factors. Additionally, purple glove syndrome has rarely been reported secondary to therapeutic doses of oral phenytoin. We report on the case of a patient who experienced international normalized ratio (INR) fluctuations upon initiation of warfarin and phenytoin concurrently and who subsequently required discontinuation of therapeutic-dose phenytoin secondary to possible purple glove syndrome...
April 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27440954/a-new-mathematical-approach-to-methadone-conversion
#18
Steven J Baumrucker, Manar Jbara, Richard Marc Rogers
No abstract text is available yet for this article.
April 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27440953/is-the-peripheral-arterial-disease-in-low-risk-type-2-diabetic-patients-influenced-by-body-mass-index-lipidemic-control-and-statins
#19
Jayesh Dalpatbhai Solanki, Amit H Makwana, Hemant B Mehta, Pradnya A Gokhale, Chinmay J Shah
OBJECTIVE: To correlate BMI, lipidemic control, and statin therapy with PAD measured by ABI in low risk type 2 diabetics. MATERIALS AND METHODS: A sample of 101 nonsmoking, asymptomatic type 2 diabetics (50 males, 51 females) with known glycemic (fasting blood sugar, postprandial blood sugar, glycosylated hemoglobin) and lipidemic (total cholesterol, lipoproteins, and triglycerides [TGAs]) control was taken. Vascular Doppler was used to derive ABI and PAD was defined as ABI <0...
April 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27440952/effect-of-losartan-and-atenolol-on-insulin-sensitivity-in-nondiabetic-hypertensive-patients
#20
Sandesh Madhukar Bharati, Nishith Singh
OBJECTIVE: To study the effects of losartan and atenolol on glucometabolic parameters in nondiabetic hypertensive patients. MATERIALS AND METHODS: In a prospective, open-label, parallel group study, nondiabetic patients with mild to moderate hypertension were randomized to either losartan (titrated from 50 to 100 mg/day, n = 20) or atenolol (titrated from 25 mg to 100 mg/day, n = 20) for period of 24 weeks. At baseline, 12 and 24 weeks fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment for insulin resistance (HOMA-IR) apart from lipid parameters, mean systolic, and diastolic blood pressures levels were determined...
April 2016: Journal of Pharmacology & Pharmacotherapeutics
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